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https://www.readbyqxmd.com/read/27905186/severe-asthma-current-management-targeted-therapies-and-future-directions-a-roundtable-report
#1
REVIEW
Vanessa M McDonald, Steven Maltby, Helen K Reddel, Gregory G King, Peter A B Wark, Lorraine Smith, John W Upham, Alan L James, Guy B Marks, Peter G Gibson
Asthma is a chronic respiratory disease characterized by respiratory symptoms, airway inflammation, airway obstruction and airway hyper-responsiveness. Asthma is common and directly affects 10% of Australians, 1-5% of adults in Asia and 300 million people worldwide. It is a heterogeneous disorder with many clinical, molecular, biological and pathophysiological phenotypes. Current management strategies successfully treat the majority of patients with asthma who have access to them. However, there is a subset of an estimated 5-10% of patients with asthma who have severe disease and are disproportionately impacted by symptoms, exacerbations and overall illness burden...
November 30, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27876327/endotracheal-intubation-with-the-king-laryngeal-tube%C3%A2-in-situ-using-video-laryngoscopy-and-a-bougie-a-retrospective-case-series-and-cadaveric-crossover-study
#2
Kenneth W Dodd, Rebecca L Kornas, Matthew E Prekker, Lauren R Klein, Robert F Reardon, Brian E Driver
BACKGROUND: Removal of a functioning King laryngeal tube (LT) prior to establishing a definitive airway increases the risk of a "can't intubate, can't oxygenate" scenario. We previously described a technique utilizing video laryngoscopy (VL) and a bougie to intubate around a well-seated King LT with the balloons deflated; if necessary, the balloons can be rapidly re-inflated and ventilation resumed. OBJECTIVE: Our objective is to provide preliminary validation of this technique...
November 19, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27871595/a-comparison-of-king-vision-video-laryngoscopy-and-direct-laryngoscopy-as-performed-by-residents-a-randomized-controlled-trial
#3
Jose A Valencia, Katherine Pimienta, Darwin Cohen, Daniel Benitez, David Romero, Oswaldo Amaya, Enrique Arango
STUDY OBJECTIVE: For more than 40 years, direct laryngoscopy (DL) has been used to assure the airway during endotracheal intubation. The King Vision video laryngoscope is one of the latest devices introduced for endotracheal intubation. We hypothesize that, relative to direct laryngoscopy, it improves the intubation success rate with fewer intubation attempts and no difference in intubation time or complications. DESIGN: This randomized controlled clinical trial included...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27863622/objective-characterization-of-airway-dimensions-using-image-processing
#4
Victoria K Pepper, Christian Francom, Cameron A Best, Ekene Onwuka, Nakesha King, Eric Heuer, Nathan Mahler, Jonathan Grischkan, Christopher K Breuer, Tendy Chiang
OBJECTIVES: With the evolution of medical and surgical management for pediatric airway disorders, the development of easily translated techniques of measuring airway dimensions can improve the quantification of outcomes of these interventions. We have developed a technique that improves the ability to characterize endoscopic airway dimensions using common bronchoscopic equipment and an open-source image-processing platform. METHODS: We validated our technique of Endoscopic Airway Measurement (EAM) using optical instruments in simulation tracheas...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27692621/use-of-king-vision-videolaryngoscope-in-an-unanticipated-difficult-airway-in-an-adult-patient-with-giant-vallecular-cyst-a-case-report
#5
L España Fuente, P de la Rica Fernández, J L González González
Laryngeal cysts are largely asymptomatic and typically described in the context of incidental discovery on routine laryngoscopy. These cysts, in adults are even rarer and can have catastrophic consequences in an anaesthetized patient if airway management is inappropriate. We describe a case of difficult endotracheal intubation and the treatment of an adult patient with an asymptomatic, giant vallecular cyst that was discovered during rapid-sequence induction of general anesthesia in urgent surgery. In conclusion, vallecular cysts can cause extreme problems in securing the airway...
September 27, 2016: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/27690714/can-ems-providers-provide-appropriate-tidal-volumes-in-a-simulated-adult-sized-patient-with-a-pediatric-sized-bag-valve-mask
#6
Jeffrey Siegler, Melissa Kroll, Susan Wojcik, Hawnwan Philip Moy
INTRODUCTION: In the prehospital setting, Emergency Medical Services (EMS) professionals rely on providing positive pressure ventilation with a bag-valve-mask (BVM). Multiple emergency medicine and critical care studies have shown that lung-protective ventilation protocols reduce morbidity and mortality. Our primary objective was to determine if a group of EMS professionals could provide ventilations with a smaller BVM that would be sufficient to ventilate patients. Secondary objectives included 1) if the pediatric bag provided volumes similar to lung-protective ventilation in the hospital setting and 2) compare volumes provided to the patient depending on the type of airway (mask, King tube, and intubation)...
October 3, 2016: Prehospital Emergency Care
https://www.readbyqxmd.com/read/27687435/king-vision-video-laryngoscope-versus-lightwand-as-an-intubating-device-in-adult-patients-with-mallampatti-grade-iii-and-iv-patients
#7
Shadab Kamal, Qazi Ehsan Ali, Syed Hussain Amir, Sarfaraz Ahmed, Krochi Pal
STUDY OBJECTIVE: Anticipated and unanticipated difficult airways are often encountered by anesthesiologists in their clinical practice. There are various devices available in such situations. We aim to compare King Vision video laryngoscope and Lightwand for their performance as an intubating device in predicted difficult intubation. DESIGN: Prospective, randomized, single blind study. SETTING: Jawaharlal Nehru Medical College. PATIENTS: Sixty ASA 1 and 2 with Mallampati grade III and IV...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27673521/obstructive-sleep-apnea-in-adults-the-role-of-upper-airway-and-facial-skeletal-surgery
#8
Ravi K Garg, Ahmed M Afifi, Ruston Sanchez, Timothy W King
Obstructive sleep apnea represents a large burden of disease to the general population and may compromise patient quality of life; workplace and automotive safety; and metabolic, cardiovascular, and neurocognitive health. The disease is characterized by repetitive cycles of upper airway collapse resulting from a lack of pharyngeal airway structural support and loss of muscle tone among upper airway dilators. Polysomnography serves as the gold standard for diagnosis of obstructive sleep apnea and the apnea-hypopnea index is the most commonly used metric for quantifying disease severity...
October 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27662773/-king-vision-video-laryngoscope-for-severe-post-burn-contracture-neck-an-encouraging-experience
#9
Qazi Ehsan Ali, Obaid Ahmed Siddiqui, Syed Hussain Amir, Sarfaraz Ahmad, Shaista Jamil
BACKGROUND AND OBJECTIVES: Managing the airway of post burn contracture of the neck has always been challenging to anesthesiologists as it limits the alignment of oro-pharyngo-laryngeal axes because of functional and anatomical deformities that occur as a result of long standing contractures. Here the role of the King Vision video laryngoscope which is the latest in the series of video laryngoscope has been evaluated for such patients. CASE REPORT: A 35 year old male patient with post burn contracture of neck was scheduled for release of the contracture...
September 20, 2016: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/27650719/tracheal-malplacement-of-the-king-lt-airway-may-be-an-important-cause-of-prehospital-device-failure
#10
Brian E Driver, David Plummer, William Heegaard, Robert F Reardon
BACKGROUND: The King LT airway (King Systems, Noblesville, IN) is a popular extraglottic device that is widely used in the prehospital setting. We report a case of tracheal malplacement of the King airway with a severe kink in the distal tube. CASE REPORT: A 51-year-old unhelmeted motorcyclist collided with a freeway median and was obtunded when paramedics arrived. After bag mask ventilation, a King airway was placed uneventfully and the patient was transported to the emergency department...
December 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27627475/an-unsuccessful-positive-airway-pressure-titration-study-on-a-young-girl-with-obstructive-sleep-apnea
#11
Lourdes M DelRosso, Michelle Y Sobremonte-King, Christopher M Cielo, Romy Hoque
No abstract text is available yet for this article.
September 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27445092/bronchial-reactivity-and-lung-function-after-world-trade-center-exposure
#12
Thomas K Aldrich, Jessica Weakley, Sean Dhar, Charles B Hall, Tesha Crosse, Gisela I Banauch, Michael D Weiden, Gabriel Izbicki, Hillel W Cohen, Aanchal Gupta, Camille King, Vasilios Christodoulou, Mayris P Webber, Rachel Zeig-Owens, William Moir, Anna Nolan, Kerry J Kelly, David J Prezant
BACKGROUND: World Trade Center (WTC)-exposed rescue/recovery workers endured massive respiratory insult from inhalation of particulate matter and gases, resulting in respiratory symptoms, loss of lung function, and, for many, bronchial hyperreactivity (BHR). The persistence of respiratory symptoms and lung function abnormalities has been well-documented, while persistence of BHR has not been investigated. METHODS: 173 WTC-exposed firefighters with bronchial reactivity measured within 2 years after 9/11/2001 (9/11), (baseline methacholine challenge test [MCT]), were re-evaluated in 2013-2014 (follow-up-MCT)...
July 18, 2016: Chest
https://www.readbyqxmd.com/read/27440636/surgicric-2-a-comparative-bench-study-with-two-established-emergency-cricothyroidotomy-techniques-in-a-porcine-model
#13
L Chrisman, W King, K Wimble, S Cartwright, K B Mohammed, B Patel
BACKGROUND: 'Can't Intubate, Can't Oxygenate' is a rare but life threatening event. Anaesthetists must be trained and have appropriate equipment available for this. The ideal equipment is a topic of ongoing debate. To date cricothyroidotomy training for anaesthetists has concentrated on cannula techniques. However cases reported to the NAP4 audit illustrated that they were associated with a high failure rate. A recent editorial by Kristensen and colleagues suggested all anaesthetists must master a surgical technique...
August 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27307726/accuracy-of-forced-oscillation-technique-to-assess-lung-function-in-geriatric-copd-population
#14
Hoi Nam Tse, Cee Zhung Steven Tseng, King Ying Wong, Kwok Sang Yee, Lai Yun Ng
INTRODUCTION: Performing lung function test in geriatric patients has never been an easy task. With well-established evidence indicating impaired small airway function and air trapping in patients with geriatric COPD, utilizing forced oscillation technique (FOT) as a supplementary tool may aid in the assessment of lung function in this population. AIMS: To study the use of FOT in the assessment of airflow limitation and air trapping in geriatric COPD patients. STUDY DESIGN: A cross-sectional study in a public hospital in Hong Kong...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27271044/g-protein-coupled-estrogen-receptor-inhibits-the-p2y-receptor-mediated-ca-2-signaling-pathway-in-human-airway-epithelia
#15
Yuan Hao, Alison W Chow, Wallace C Yip, Chi H Li, Tai F Wan, Benjamin C Tong, King H Cheung, Wood Y Chan, Yangchao Chen, Christopher H Cheng, Wing H Ko
P2Y receptor activation causes the release of inflammatory cytokines in the bronchial epithelium, whereas G protein-coupled estrogen receptor (GPER), a novel estrogen (E2) receptor, may play an anti-inflammatory role in this process. We investigated the cellular mechanisms underlying the inhibitory effect of GPER activation on the P2Y receptor-mediated Ca(2+) signaling pathway and cytokine production in airway epithelia. Expression of GPER in primary human bronchial epithelial (HBE) or 16HBE14o- cells was confirmed on both the mRNA and protein levels...
August 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27255874/intubation-performance-of-advanced-airway-devices-in-a-helicopter-emergency-medical-service-setting
#16
John W Hafner, Blake W Perkins, Joshua D Korosac, Alayna K Bucher, Jean C Aldag, Kelly L Cox
OBJECTIVE: This study attempts to determine if newer indirect laryngoscopes or intubating devices are superior to a standard laryngoscope for intubation success among helicopter emergency medical service (HEMS) personnel. METHODS: Flight nurses and paramedics intubated standardized mannequins with a normal airway, a trauma airway, and a difficult airway using a standard laryngoscope, a gum elastic bougie, the Airtraq laryngoscope (King System Corp, Noblesville, IN), the Glidescope Ranger laryngoscope (Verathon Inc, Bothell, WA), and the S...
May 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27177733/aspergillus-infections-in-cystic-fibrosis
#17
Jill King, Shan F Brunel, Adilia Warris
Patients with cystic fibrosis (CF) suffer from chronic lung infection and airway inflammation. Respiratory failure secondary to chronic or recurrent infection remains the commonest cause of death and accounts for over 90% of mortality. Bacteria as Staphylococcus aureus, Pseudomonas aeruginosa and Burkholderia cepacia complex have been regarded the main CF pathogens and their role in progressive lung decline has been studied extensively. Little attention has been paid to the role of Aspergillus spp. and other filamentous fungi in the pathogenesis of non-ABPA (allergic bronchopulmonary aspergillosis) respiratory disease in CF, despite their frequent recovery in respiratory samples...
July 5, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27171733/a-comparison-of-three-videolaryngoscopes-for-double-lumen-tubes-intubation-in-simulated-easy-and-difficult-airways-a-randomised-trial
#18
Mohamed R El Tahan, Abdulmohsen A Al-Ghamdi, Alaa Khidr, Ihab S Gaarour
BACKGROUND: The King VisionTM (KVL) and Airtraq® may reduce the time to double lumen tube (DLT) intubation compared with the GlideScope® and Macintosh in simulated easy and difficult airways. METHODS: Twenty-one consented staff anaesthesiologists who had limited prior experience in using videolaryngoscopes for DLT intubation were assigned randomly to insert a DLT using the Macintosh, GlideScope®, Airtraq® and KVL on easy and difficult airway simulators in a randomized crossover order...
May 12, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27140677/bronchodilator-responsiveness-of-peripheral-airways-in-smokers-with-normal-spirometry
#19
Kanika Jetmalani, David G Chapman, Cindy Thamrin, Claude S Farah, Norbert Berend, Cheryl M Salome, Gregory G King
BACKGROUND AND OBJECTIVE: Cigarette smoke exposure increases airway smooth muscle (ASM) contractility. Abnormalities in peripheral airway function in smokers with normal spirometry could be due to the effects of ASM tone. We aimed to determine the contribution of ASM tone to peripheral airway function in smokers with normal spirometry from the response to bronchodilator (BD). METHODS: Ventilation heterogeneity in peripheral conductive (Scond) and acinar (Sacin) airways were measured in 50 asymptomatic smokers and 20 never-smokers using multiple breath nitrogen washout, before and 20 min after inhalation of 200 µg salbutamol and 80 µg ipratropium bromide...
October 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27136407/obstructive-sleep-apnea-as-an-independent-stroke-risk-factor-a-review-of-the-evidence-stroke-prevention-guidelines-and-implications-for-neuroscience-nursing-practice
#20
Sharon King, Norma Cuellar
BACKGROUND: Stroke is a leading cause of death and disability affecting nearly 800,000 people in the United States every year. Obstructive sleep apnea (OSA) is found in over 60% of patients with stroke/transient ischemic attack (TIA) and identified as an independent stroke risk factor in large epidemiology studies and Canadian Stroke Prevention Guidelines (SPG) but not in the United States. The 2014 Secondary SPG recommend OSA screening and treatment as a consideration only, not a requirement...
June 2016: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
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