Liudmila Leppik, Han Zhihua, Sahba Mobini, Vishnu Thottakkattumana Parameswaran, Maria Eischen-Loges, Andrei Slavici, Judith Helbing, Lukas Pindur, Karla M C Oliveira, Mit B Bhavsar, Lukasz Hudak, Dirk Henrich, John H Barker
Bone Tissue engineering (BTE) has recently been introduced as an alternative to conventional treatments for large non-healing bone defects. BTE approaches mimic autologous bone grafts, by combining cells, scaffold, and growth factors, and have the added benefit of being able to manipulate these constituents to optimize healing. Electrical stimulation (ES) has long been used to successfully treat non-healing fractures and has recently been shown to stimulate bone cells to migrate, proliferate, align, differentiate, and adhere to bio compatible scaffolds, all cell behaviors that could improve BTE treatment outcomes...
April 20, 2018: Scientific Reports