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https://www.readbyqxmd.com/read/29668132/-shtlv-i-ii-seroprevalence-in-blood-donors-of-hospital-pablo-tob%C3%A3-n-uribe-blood-bank-during-the-period-2014-2015
#1
Manuela Muñoz, Santiago Carvalho, Jorge Hernando Donado, Gloria Eugenia Barco, Sergio Jaramillo
INTRODUCTION: The human-T cell lymphotropic virus is a retrovirus with various types known so far. HTLV-I and HTLV-II are of clinically importance as they cause different diseases such as adult T-cell leukemia/lymphoma, tropical spastic paraparesis, and human T-lymphotropic virus type I-associated myelopathy (HAM). OBJECTIVE: To estimate the prevalence of presumptive and confirmatory reactivity to HTLV-I/II in blood donors of Hospital Pablo Tobón Uribe Blood Bank between 2014 and 2015...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667908/the-macula-densa-prorenin-receptor-is-essential-in-renin-release-and-blood-pressure-control
#2
Anne D M Riquier-Brison, Arnold Sipos, Ágnes Prókai, Sarah L Vargas, Ildiko Toma, Elliott J Meer, Karie G Villanueva, Jennifer C M Chen, Georgina Gyarmati, Christopher Yih, Elaine Tang, Bahram Nadim, Sujith Pendekanti, Ingrid M Garrelds, Genevieve Nguyen, A H Jan Danser, Janos Peti-Peterdi
The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS), however recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglomerular apparatus (JGA), a classic anatomical site of the RAS. PRR expression was found in the sensory cells of the JGA, the macula densa (MD), and immunohistochemistry localized PRR to the MD basolateral cell membrane in mouse, rat, and human kidneys. MD cell PRR activation led to MAP kinase ERK1/2 signaling and stimulation of PGE2 release, the classic pathway of MD-mediated renin release...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667689/no-unjamming-transition-in-a-voronoi-model-of-biological-tissue
#3
Daniel M Sussman, Matthias Merkel
Vertex models are a popular approach to simulating the mechanical and dynamical properties of dense biological tissues, describing the tissue as a network of polygons. Recently a class of two-dimensional vertex models was shown to exhibit a disordered rigidity transition controlled by the preferred cellular geometry, which was subsequently echoed by experimental findings. An attractive variant of these models uses a Voronoi tessellation to describe the cells, which reduces the number of degrees of freedom as compared the original vertex model...
April 18, 2018: Soft Matter
https://www.readbyqxmd.com/read/29667493/non-adenomatous-pituitary-tumours-mimicking-functioning-pituitary-adenomas
#4
Zize Feng, Zhigang Mao, Zongming Wang, Bing Liao, Yonghong Zhu, Haijun Wang
OBJECTIVE: Pituicytomas and granular cell tumours (GCTs) of the neurohypophysis are considered non-adenomatous neoplasms in the sellar region. The association between hormone hypersecretion and the tumours is seldom discussed and unclear. Therefore, we attempt to investigate this association based on our experience and a review of the literature. METHODS: We report three patients who presented with Cushing's syndrome- or acromegaly-like symptoms at our institution...
April 18, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29667289/endosomal-receptor-trafficking-retromer-and-beyond
#5
REVIEW
Jing Wang, Alina Fedoseienko, Bayou Chen, Ezra Burstein, Da Jia, Daniel D Billadeau
The tubular endolysosomal network is a quality control system that ensures the proper delivery of internalized receptors to specific subcellular destinations in order to maintain cellular homeostasis. Although retromer was originally described in yeast as a regulator of endosome-to-Golgi receptor recycling, mammalian retromer has emerged as a central player in endosome-to-plasma membrane recycling of a variety of receptors. Over the past decade, information regarding the mechanism by which retromer facilitates receptor trafficking has emerged, as has the identification of numerous retromer-associated molecules including the WASH complex, sorting nexins and TBC1d5...
April 18, 2018: Traffic
https://www.readbyqxmd.com/read/29667248/establishment-of-a-radiotelemetric-recording-technique-in-mice-to-investigate-gastric-slow-waves-modulatory-role-of-putative-neurotransmitter-systems
#6
Huichuan Wang, Zengbing Lu, Yuen Hang Liu, Yayi Sun, Longlong Tu, Man P Ngan, Chi-Kong Yeung, John A Rudd
NEW FINDINGS: What is the central question of this study? Gastric slow waves originating from interstitial cells of Cajal-smooth muscle syncytium are usually studied in culture or in tissue segments, but no studies have made recording of slow waves from conscious freely moving mice. Can radiotelemetry be used to record slow waves, and do they respond predictably to drug treatment? What is the main finding and its importance? Radiotelemetry may be used to record slow waves from conscious freely moving mice permitting an examination of drug action in vivo, which is critical to drug discovery projects characterizing drugs and metabolites on gastrointestinal function...
April 18, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29667243/a-biopolymer-heparin-sodium-interlayer-anchoring-tio-2-and-mapbi-3-enhances-trap-passivation-and-device-stability-in-perovskite-solar-cells
#7
Shuai You, Hui Wang, Shiqing Bi, Jiyu Zhou, Liang Qin, Xiaohui Qiu, Zhiqiang Zhao, Yun Xu, Yuan Zhang, Xinghua Shi, Huiqiong Zhou, Zhiyong Tang
Traps in the photoactive layer or interface can critically influence photovoltaic device characteristics and stabilities. Here, traps passivation and retardation on device degradation for methylammonium lead trihalide (MAPbI3 ) perovskite solar cells enabled by a biopolymer heparin sodium (HS) interfacial layer is investigated. The incorporated HS boosts the power conversion efficiency from 17.2 to 20.1% with suppressed hysteresis and Shockley-Read-Hall recombination, which originates primarily from the passivation of traps near the interface between the perovskites and the TiO2 cathode...
April 18, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29666910/ontogeny-and-development-of-the-tritocerebral-commissure-giant-tcg-an-identified-neuron-in-the-brain-of-the-grasshopper-schistocerca-gregaria
#8
George Stephen Boyan, Leslie Williams, Tobias Müller, Jonathan P Bacon
The tritocerebral commissure giant (TCG) of the grasshopper Schistocerca gregaria is one of the best anatomically and physiologically described arthropod brain neurons. A member of the so-called Ventral Giant cluster of cells, it integrates sensory information from visual, antennal and hair receptors, and synapses with thoracic motor neurons in order to initiate and regulate flight behavior. Its ontogeny, however, remains unclear. In this study, we use bromodeoxyuridine incorporation and cyclin labeling to reveal proliferative neuroblasts in the region of the embryonic brain where the ventral giant cluster is located...
April 17, 2018: Development Genes and Evolution
https://www.readbyqxmd.com/read/29666909/-aggressive-b%C3%A2-cell-lymphomas-recommendations-from-the-german-panel-of-reference-pathologists-in-the-competence-network-on-malignant-lymphomas-on-diagnostic-procedures-according-to-the-current-who-classification-update-2017
#9
REVIEW
W Klapper, F Fend, A Feller, M L Hansmann, P Möller, H Stein, A Rosenwald, G Ott
The update of the 4th edition of the WHO classification for hematopoietic neoplasms introduces changes in the field of mature aggressive B‑cell lymphomas that are relevant to diagnostic pathologists. In daily practice, the question arises of which analysis should be performed when diagnosing the most common lymphoma entity, diffuse large B‑cell lymphoma. We discuss the importance of the cell of origin, the analysis of MYC translocations, and the delineation of the new WHO entities of high-grade B‑cell lymphomas...
April 17, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29666564/neural-induction-potential-and-mri-of-adscs-labeled-cationic-superparamagnetic-iron-oxide-nanoparticle-in-vitro
#10
Weiqiong Ma, Qi Xie, Baolin Zhang, Huixian Chen, Jianyi Tang, Zhengxian Lei, Minyi Wu, Dingxuan Zhang, Jiani Hu
Magnetic resonance imaging (MRI) combined with contrast agents is believed to be useful for stem cell tracking in vivo, and the aim of this research was to investigate the biosafety and neural induction of SD rat-originated adipose derived stem cells (ADSCs) using cationic superparamagnetic iron oxide (SPIO) nanoparticle which was synthesized by the improved polyol method, in order to allow visualization using in vitro MRI. The scan protocols were performed with T2-mapping sequence; meanwhile, the ultrastructure of labeled cells was observed by transmission electron microscopy (TEM) while the iron content was measured by inductively coupled plasma-atomic emission spectrometry (ICP-AES)...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29666441/using-biology-to-guide-the-treatment-of-sarcomas-and-aggressive-connective-tissue-tumours
#11
REVIEW
Armelle Dufresne, Mehdi Brahmi, Marie Karanian, Jean-Yves Blay
Sarcomas are a heterogeneous group of malignancies that arise from cells of a mesenchymal origin. Surgery forms the mainstay of the treatment of most patients with localized sarcoma and might be followed or preceded by chemotherapy and/or radiotherapy. In the metastatic setting, systemic treatments tend to improve survival and control symptoms. However, the adverse events and sometimes disappointing outcomes associated with these empirical approaches to treatment indicate a need for new approaches. The advent of next-generation sequencing (NGS) has enabled more targeted treatment of many malignancies based on the presence of specific alterations...
April 17, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29666283/the-origin-dynamic-morphology-and-pi4p-independent-formation-of-encephalomyocarditis-virus-replication-organelles
#12
C E Melia, H M van der Schaar, A W M de Jong, H R Lyoo, E J Snijder, A J Koster, F J M van Kuppeveld, M Bárcena
Picornaviruses induce dramatic rearrangements of endomembranes in the cells that they infect to produce dedicated platforms for viral replication. These structures, termed replication organelles (ROs), have been well characterized for the Enterovirus genus of the Picornaviridae However, it is unknown whether the diverse RO morphologies associated with enterovirus infection are conserved among other picornaviruses. Here, we use serial electron tomography at different stages of infection to assess the three-dimensional architecture of ROs induced by encephalomyocarditis virus (EMCV), a member of the Cardiovirus genus of the family of picornaviruses that is distantly related...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29666271/desynchronization-of-slow-oscillations-in-the-basal-ganglia-during-natural-sleep
#13
Aviv D Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Hagai Bergman
Slow oscillations of neuronal activity alternating between firing and silence are a hallmark of slow-wave sleep (SWS). These oscillations reflect the default activity present in all mammalian species, and are ubiquitous to anesthesia, brain slice preparations, and neuronal cultures. In all these cases, neuronal firing is highly synchronous within local circuits, suggesting that oscillation-synchronization coupling may be a governing principle of sleep physiology regardless of anatomical connectivity. To investigate whether this principle applies to overall brain organization, we recorded the activity of individual neurons from basal ganglia (BG) structures and the thalamocortical (TC) network over 70 full nights of natural sleep in two vervet monkeys...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666211/drivers-of-persistent-infection-pathogen-induced-extracellular-vesicles
#14
REVIEW
Michael J Cipriano, Stephen L Hajduk
Extracellular vesicles (EVs) are produced by invading pathogens and also by host cells in response to infection. The origin, composition, and function of EVs made during infection are diverse and provide effective vehicles for localized and broad dissimilation of effector molecules in the infected host. Extracellular pathogens use EVs to communicate with each other by sensing the host environment contributing to social motility, tissue tropism, and persistence of infection. Pathogen-derived EVs can also interact with host cells to influence the adhesive properties of host membranes and to alter immune recognition and response...
April 17, 2018: Essays in Biochemistry
https://www.readbyqxmd.com/read/29666115/genetics-of-diffuse-large-b-cell-lymphoma
#15
Laura Pasqualucci, Riccardo Dalla-Favera
Diffuse large B cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy, remains a significant clinical challenge, as approximately 30% of patients are not cured. Over the past decade, remarkable progress has been made in the understanding of the pathogenesis of this disease, spurred by the implementation of powerful genomic technologies that enabled the definition of its genetic and epigenetic landscape. These studies have uncovered a multitude of genomic alterations that contribute to the initiation and maintenance of the tumor clone by disrupting biological functions known to be critical for the normal biology of its cells of origin, germinal center B cells...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29666114/chronic-lymphocytic-leukemia-and-mantle-cell-lymphoma-crossroads-of-genetic-and-microenvironment-interactions
#16
Xose S Puente, Pedro Jares, Elias Campo
Chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) are two well defined entities that diverge in their basic pathogenic mechanisms and clinical evolution but they share epidemiological characteristics, cells of origin, molecular alterations, and clinical features that differ from other lymphoid neoplasms. CLL and MCL are classically considered indolent and aggressive neoplasms, respectively. However, the clinical evolution of both tumors is very heterogeneous, with subsets of patients having a stable disease for long time whereas others require immediate intervention...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29665916/-characteristics-and-diagnostic-values-of-bone-marrow-cell-morphology-and-immunophenotyping-in-lymphoma-cell-leukemia
#17
Wen-Juan Wang, Juan Zhao, Peng-Cheng He, Xiao-Ning Wang
OBJECTIVE: To explore the characteristics and diagnostic values of bone marrow cell morphology and immunophenotyping in lymphoma cell leukemia patients. METHODS: Data of the bone marrow cell morphology and immunophenotyping of 35 patients with lymphoma cell leukemia admitted from January 2012 to January 2017 were analyzed retrospectively, and the value of bone marrow cell morphology and immunophenotype in the diagnosis of lymphoma cell leukemia was evaluated. RESULTS: Bone marrow cell morphological examination showed the typical lymphoma cells in all the patients...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665915/-clinical-significance-of-hbv-detection-in-nhl-patients
#18
Tian-Ling Zhang, Juan Zhang, Cheng-Xiu Lv, Tian-Yu Hu, Qing Li
OBJECTIVE: To analyze the relation of HBV infection with clinical characteristics and prognosis in NHL patients, so as to explore the significance of HBV detection. METHODS: Sixty-eight NHL patients from December 2013 to December 2016 were enrolled in NHL group and 136 patients with other malignancies were chosen in control group, the detectable rate of HBV was compared between 2 groups. The correlation of HBV infection with sex, age, stage, cell origin, expression of P53 and BCL-2 in NHL patients was analyzed...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665913/-analysis-of-the-clinicopathological-characteristics-treatment-and-prognosis-of-unclassifiable-b-cell-lymphoma-intermediated-between-dlcbl-and-bl
#19
De-Liang Liu, Biao Wang, Yuan-Dong Zhu, Feng Yan
OBJECTIVE: To analyze the clinicopathological characteristics, treatment and prognosis of patients with unclassifiable B-cell lymphoma intermediated between DLCBL and BL. METHODS: A total of 16 patients with DLBCL/BL in our hospital were included in this study between July 2014 and June 2016. The clinical and pathological data of 16 patients were collected. Kaplan-Meier method was used to estimate and compare overall survival (OS) and progression-free survival (PFS)...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665776/correction-to-tissue-and-cell-specific-transcriptomes-in-cotton-reveal-the-subtleties-of-gene-regulation-underlying-the-diversity-of-plant-secondary-cell-walls
#20
Colleen P MacMillan, Hannah Birke, Aaron Chuah, Elizabeth Brill, Yukiko Tsuji, John Ralph, Elizabeth S Dennis, Danny Llewellyn, Filomena A Pettolino
Upon publication of the original article [1], the authors had flagged that Fig. 1 had been published twice, as both Fig. 1 and Additional file 3.
April 17, 2018: BMC Genomics
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