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https://www.readbyqxmd.com/read/29787865/a-comparison-of-three-fiber-tract-delineation-methods-and-their-impact-on-white-matter-analysis
#1
Valerie J Sydnor, Ana María Rivas-Grajales, Amanda E Lyall, Fan Zhang, Sylvain Bouix, Sarina Karmacharya, Martha E Shenton, Carl-Fredrik Westin, Nikos Makris, Demian Wassermann, Lauren J O'Donnell, Marek Kubicki
Diffusion magnetic resonance imaging (dMRI) is an important method for studying white matter connectivity in the brain in vivo in both healthy and clinical populations. Improvements in dMRI tractography algorithms, which reconstruct macroscopic three-dimensional white matter fiber pathways, have allowed for methodological advances in the study of white matter; however, insufficient attention has been paid to comparing post-tractography methods that extract white matter fiber tracts of interest from whole-brain tractography...
May 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29773973/comprehensive-investigation-of-white-matter-tracts-in-professional-chess-players-and-relation-to-expertise-region-of-interest-and-dmri-connectometry
#2
Mahsa Mayeli, Farzaneh Rahmani, Mohammad Hadi Aarabi
Purpose: Expertise is the product of training. Few studies have used functional connectivity or conventional diffusometric methods to identify neural underpinnings of chess expertise. Diffusometric variables of white matter might reflect these adaptive changes, along with changes in structural connectivity, which is a sensitive measure of microstructural changes. Method: Diffusometric variables of 29 professional chess players and 29 age-sex matched controls were extracted for white matter regions based on John Hopkin's Mori white matter atlas and partially correlated against professional training time and level of chess proficiency...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29749094/magnetic-resonance-spectroscopy-of-fiber-tracts-in-children-with-traumatic-brain-injury-a-combined-mrs-diffusion-mri-study
#3
Emily L Dennis, Talin Babikian, Jeffry Alger, Faisal Rashid, Julio E Villalon-Reina, Yan Jin, Alexander Olsen, Richard Mink, Christopher Babbitt, Jeffrey Johnson, Christopher C Giza, Paul M Thompson, Robert F Asarnow
Traumatic brain injury can cause extensive damage to the white matter (WM) of the brain. These disruptions can be especially damaging in children, whose brains are still maturing. Diffusion magnetic resonance imaging (dMRI) is the most commonly used method to assess WM organization, but it has limited resolution to differentiate causes of WM disruption. Magnetic resonance spectroscopy (MRS) yields spectra showing the levels of neurometabolites that can indicate neuronal/axonal health, inflammation, membrane proliferation/turnover, and other cellular processes that are on-going post-injury...
May 10, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29727508/characterizing-intra-axonal-water-diffusion-with-direction-averaged-triple-diffusion-encoding-mri
#4
Jens H Jensen, Joseph A Helpern
For large diffusion weightings, the direction-averaged diffusion MRI (dMRI) signal from white matter is typically dominated by the contribution of water confined to axons. This fact can be exploited to characterize intra-axonal diffusion properties, which may be valuable for interpreting the biophysical meaning of diffusion changes associated with pathology. However, using just the classic Stejskal-Tanner pulse sequence, it has proven challenging to obtain reliable estimates for both the intrinsic intra-axonal diffusivity and the intra-axonal water fraction...
May 4, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29691374/toward-personalised-diffusion-mri-in-psychiatry-improved-delineation-of-fibre-bundles-with-the-highest-ever-angular-resolution-in-vivo-tractography
#5
Fraser Callaghan, Jerome J Maller, Thomas Welton, Matthew J Middione, Ajit Shankaranarayanan, Stuart M Grieve
Diffusion MRI (dMRI) tractography is a uniquely powerful tool capable of demonstrating structural brain network abnormalities across a range of psychiatric disorders; however, it is not currently clinically useful. This is because limitations on sensitivity effectively restrict its application to scientific studies of cohorts, rather than individual patients. Recent improvements in dMRI hardware, acquisition, processing and analysis techniques may, however, overcome these measurement limitations. We therefore acquired the highest-ever angular resolution in vivo tractographic data set, and used these data to ask the question: 'is cutting-edge, optimised dMRI now sensitive enough to measure brain network abnormalities at a level that may enable personalised psychiatry?' The fibre tracking performance of this 'gold standard' data set of 1150 unique directions (11 shells) was compared to a conventional 64-direction protocol (single shell) and a clinically practical, highly optimised and accelerated 9-min protocol of 140 directions (3 shells)...
April 25, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29675944/advanced-mr-diffusion-imaging-and-chemotherapy-related-changes-in-cerebral-white-matter-microstructure-of-survivors-of-childhood-bone-and-soft-tissue-sarcoma
#6
Charlotte Sleurs, Jurgen Lemiere, Daan Christiaens, Thibo Billiet, Ronald Peeters, Stefan Sunaert, Anne Uyttebroeck, Sabine Deprez
With the increase of survival rates of pediatric cancer patients, the number of children facing potential cognitive sequelae has grown. Previous adult studies suggest that white matter (WM) microstructural changes may contribute to cognitive impairment. This study aims to investigate WM microstructure in childhood bone and soft tissue sarcoma. Differences in (micro-)structure can be investigated using diffusion MRI (dMRI). The typically used diffusion tensor model (DTI) assumes Gaussian diffusion, and lacks information about fiber populations...
April 20, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29672917/a-joint-space-angle-regularization-approach-for-single-4d-diffusion-image-super-resolution
#7
Shi Yin, Xinge You, Xin Yang, Qinmu Peng, Ziqi Zhu, Xiao-Yuan Jing
PURPOSE: Low signal-to-noise-ratio and limited scan time of diffusion magnetic resonance imaging (dMRI) in current clinical settings impede obtaining images with high spatial and angular resolution (HSAR) for a reliable fiber reconstruction with fine anatomical details. To overcome this problem, we propose a joint space-angle regularization approach to reconstruct HSAR diffusion signals from a single 4D low resolution (LR) dMRI, which is down-sampled in both 3D-space and q-space. METHODS: Different from the existing works which combine multiple 4D LR diffusion images acquired using specific acquisition protocols, the proposed method reconstructs HSAR dMRI from only a single 4D dMRI by exploring and integrating two key priors, that is, the nonlocal self-similarity in the spatial domain as a prior to increase spatial resolution and ridgelet approximations in the diffusion domain as another prior to increase the angular resolution of dMRI...
April 19, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29672517/white-matter-alterations-in-the-internal-capsule-and-psychomotor-impairment-in-melancholic-depression
#8
Matthew P Hyett, Alistair Perry, Michael Breakspear, Wei Wen, Gordon B Parker
Emerging evidence suggests that structural brain abnormalities may play a role in the pathophysiology of melancholic depression. We set out to test whether diffusion-derived estimates of white matter structure were disrupted in melancholia in regions underpinning psychomotor function. We hypothesized that those with melancholia (and evidencing impaired psychomotor function) would show disrupted white matter organization in internal capsule subdivisions. Diffusion magnetic resonance imaging (dMRI) data were acquired from 22 melancholic depressed, 23 non-melancholic depressed, and 29 healthy control participants...
2018: PloS One
https://www.readbyqxmd.com/read/29660512/modeling-white-matter-microstructure-with-fiber-ball-imaging
#9
Emilie T McKinnon, Joseph A Helpern, Jens H Jensen
Fiber ball imaging (FBI) provides a means of calculating the fiber orientation density function (fODF) in white matter from diffusion MRI (dMRI) data obtained over a spherical shell with a b-value of about 4000 s/mm2 or higher. By supplementing this FBI-derived fODF with dMRI data acquired for two lower b-value shells, it is shown that several microstructural parameters may be estimated, including the axonal water fraction (AWF) and the intrinsic intra-axonal diffusivity. This fiber ball white matter (FBWM) modeling method is demonstrated for dMRI data acquired from healthy volunteers, and the results are compared with those of the white matter tract integrity (WMTI) method...
April 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29655938/delineation-of-early-brain-development-from-fetuses-to-infants-with-diffusion-mri-and-beyond
#10
REVIEW
Minhui Ouyang, Jessica Dubois, Qinlin Yu, Pratik Mukherjee, Hao Huang
Dynamic macrostructural and microstructural changes take place from the mid-fetal stage to 2 years after birth. Delineating brain structural changes during this early developmental period provides new insights into the complicated processes of both typical brain development and the pathological mechanisms underlying various psychiatric and neurological disorders including autism, attention deficit hyperactivity disorder and schizophrenia. Decades of histological studies have identified strong spatial and functional gradients of maturation in human brain gray and white matter...
April 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29623392/clinical-utility-of-dynamic-enhanced-mri-in-salivary-gland-tumors-retrospective-study-and-literature-review
#11
Takenori Ogawa, Ikuho Kojima, Ryo Ishii, Maya Sakamoto, Takaki Murata, Takahiro Suzuki, Kengo Kato, Ayako Nakanome, Akira Ohkoshi, Eiichi Ishida, Seiji Kakehata, Kiyoto Shiga, Yukio Katori
PURPOSE: To improve the diagnoses of the salivary gland tumors, a dynamic-enhanced MRI (dMRI) was investigated. METHODS: We conducted a retrospective chart review of 93 cases of salivary gland tumors. The histological diagnoses were obtained from all patients using a surgical specimen and/or an open biopsy specimen. The dMRI as well as fine-needle aspiration cytology (FNAC) and intraoperative frozen section (IFS) were analyzed. This study focused on the time-intensity curve (TIC) after injection, peak time (Tpeak), washout ratio (WR) as well as the gradient of enhancement and washout profile...
April 6, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29607548/motion-robust-sub-millimeter-isotropic-diffusion-imaging-through-motion-corrected-generalized-slice-dithered-enhanced-resolution-mc-gslider-acquisition
#12
Fuyixue Wang, Berkin Bilgic, Zijing Dong, Mary Kate Manhard, Ned Ohringer, Bo Zhao, Melissa Haskell, Stephen F Cauley, Qiuyun Fan, Thomas Witzel, Elfar Adalsteinsson, Lawrence L Wald, Kawin Setsompop
PURPOSE: To develop an efficient MR technique for ultra-high resolution diffusion MRI (dMRI) in the presence of motion. METHODS: gSlider is an SNR-efficient high-resolution dMRI acquisition technique. However, subject motion is inevitable during a prolonged scan for high spatial resolution, leading to potential image artifacts and blurring. In this study, an integrated technique termed Motion Corrected gSlider (MC-gSlider) is proposed to obtain high-quality, high-resolution dMRI in the presence of large in-plane and through-plane motion...
April 1, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29604453/bayesian-uncertainty-quantification-in-linear-models-for-diffusion-mri
#13
Jens Sjölund, Anders Eklund, Evren Özarslan, Magnus Herberthson, Maria Bånkestad, Hans Knutsson
Diffusion MRI (dMRI) is a valuable tool in the assessment of tissue microstructure. By fitting a model to the dMRI signal it is possible to derive various quantitative features. Several of the most popular dMRI signal models are expansions in an appropriately chosen basis, where the coefficients are determined using some variation of least-squares. However, such approaches lack any notion of uncertainty, which could be valuable in e.g. group analyses. In this work, we use a probabilistic interpretation of linear least-squares methods to recast popular dMRI models as Bayesian ones...
March 28, 2018: NeuroImage
https://www.readbyqxmd.com/read/29603381/high-resolution-whole-brain-diffusion-mri-at-7t-using-radiofrequency-parallel-transmission
#14
Xiaoping Wu, Edward J Auerbach, An T Vu, Steen Moeller, Christophe Lenglet, Sebastian Schmitter, Pierre-François Van de Moortele, Essa Yacoub, Kâmil Uğurbil
PURPOSE: Investigating the utility of RF parallel transmission (pTx) for Human Connectome Project (HCP)-style whole-brain diffusion MRI (dMRI) data at 7 Tesla (7T). METHODS: Healthy subjects were scanned in pTx and single-transmit (1Tx) modes. Multiband (MB), single-spoke pTx pulses were designed to image sagittal slices. HCP-style dMRI data (i.e., 1.05-mm resolutions, MB2, b-values = 1000/2000 s/mm2 , 286 images and 40-min scan) and data with higher accelerations (MB3 and MB4) were acquired with pTx...
March 30, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29578031/the-unc-umn-baby-connectome-project-bcp-an-overview-of-the-study-design-and-protocol-development
#15
REVIEW
Brittany R Howell, Martin A Styner, Wei Gao, Pew-Thian Yap, Li Wang, Kristine Baluyot, Essa Yacoub, Geng Chen, Taylor Potts, Andrew Salzwedel, Gang Li, John H Gilmore, Joseph Piven, J Keith Smith, Dinggang Shen, Kamil Ugurbil, Hongtu Zhu, Weili Lin, Jed T Elison
The human brain undergoes extensive and dynamic growth during the first years of life. The UNC/UMN Baby Connectome Project (BCP), one of the Lifespan Connectome Projects funded by NIH, is an ongoing study jointly conducted by investigators at the University of North Carolina at Chapel Hill and the University of Minnesota. The primary objective of the BCP is to characterize brain and behavioral development in typically developing infants across the first 5 years of life. The ultimate goals are to chart emerging patterns of structural and functional connectivity during this period, map brain-behavior associations, and establish a foundation from which to further explore trajectories of health and disease...
March 22, 2018: NeuroImage
https://www.readbyqxmd.com/read/29549287/function-specific-and-enhanced-brain-structural-connectivity-mapping-via-joint-modeling-of-diffusion-and-functional-mri
#16
Shu-Hsien Chu, Keshab K Parhi, Christophe Lenglet
A joint structural-functional brain network model is presented, which enables the discovery of function-specific brain circuits, and recovers structural connections that are under-estimated by diffusion MRI (dMRI). Incorporating information from functional MRI (fMRI) into diffusion MRI to estimate brain circuits is a challenging task. Usually, seed regions for tractography are selected from fMRI activation maps to extract the white matter pathways of interest. The proposed method jointly analyzes whole brain dMRI and fMRI data, allowing the estimation of complete function-specific structural networks instead of interactively investigating the connectivity of individual cortical/sub-cortical areas...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29515362/on-the-viability-of-diffusion-mri-based-microstructural-biomarkers-in-ischemic-stroke
#17
Ilaria Boscolo Galazzo, Lorenza Brusini, Silvia Obertino, Mauro Zucchelli, Cristina Granziera, Gloria Menegaz
Recent tract-based analyses provided evidence for the exploitability of 3D-SHORE microstructural descriptors derived from diffusion MRI (dMRI) in revealing white matter (WM) plasticity. In this work, we focused on the main open issues left: (1) the comparative analysis with respect to classical tensor-derived indices, i.e., Fractional Anisotropy (FA) and Mean Diffusivity (MD); and (2) the ability to detect plasticity processes in gray matter (GM). Although signal modeling in GM is still largely unexplored, we investigated their sensibility to stroke-induced microstructural modifications occurring in the contralateral hemisphere...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29507311/voxel-wise-comparisons-of-cellular-microstructure-and-diffusion-mri-in-mouse-hippocampus-using-3d-bridging-of-optically-clear-histology-with-neuroimaging-data-3d-bond
#18
H B Stolp, G Ball, P-W So, J-D Tournier, M Jones, C Thornton, A D Edwards
A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology. We present a new technique, 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND), for registering medical images with 3D histology to overcome these limitations. Ex vivo 120 × 120 × 200 μm resolution diffusion-MRI (dMRI) data was acquired at 7 T from adult C57Bl/6 mouse hippocampus...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29490005/diversity-of-cortico-descending-projections-histological-and-diffusion-mri-characterization-in-the-monkey
#19
Giorgio M Innocenti, Roberto Caminiti, Eric M Rouiller, Graham Knott, Tim B Dyrby, Maxime Descoteaux, Jean-Philippe Thiran
The axonal composition of cortical projections originating in premotor, supplementary motor (SMA), primary motor (a4), somatosensory and parietal areas and descending towards the brain stem and spinal cord was characterized in the monkey with histological tract tracing, electron microscopy (EM) and diffusion MRI (dMRI). These 3 approaches provided complementary information. Histology provided accurate assessment of axonal diameters and size of synaptic boutons. dMRI revealed the topography of the projections (tractography), notably in the internal capsule...
February 27, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29486323/the-impact-of-in-scanner-head-motion-on-structural-connectivity-derived-from-diffusion-mri
#20
Graham L Baum, David R Roalf, Philip A Cook, Rastko Ciric, Adon F G Rosen, Cedric Xia, Mark A Elliott, Kosha Ruparel, Ragini Verma, Birkan Tunç, Ruben C Gur, Raquel E Gur, Danielle S Bassett, Theodore D Satterthwaite
Multiple studies have shown that data quality is a critical confound in the construction of brain networks derived from functional MRI. This problem is particularly relevant for studies of human brain development where important variables (such as participant age) are correlated with data quality. Nevertheless, the impact of head motion on estimates of structural connectivity derived from diffusion tractography methods remains poorly characterized. Here, we evaluated the impact of in-scanner head motion on structural connectivity using a sample of 949 participants (ages 8-23 years old) who passed a rigorous quality assessment protocol for diffusion magnetic resonance imaging (dMRI) acquired as part of the Philadelphia Neurodevelopmental Cohort...
June 2018: NeuroImage
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