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https://www.readbyqxmd.com/read/28351023/effect-of-door-locking-policy-on-inpatient-treatment-of-substance-use-and-dual-disorders
#1
Regine Steinauer, Christian G Huber, Sylvie Petitjean, Gerhard A Wiesbeck, Kenneth M Dürsteler, Undine E Lang, Christian Seifert, Katja Andreeff, Michael Krausz, Marc Walter, Marc Vogel
OBJECTIVE: Substance use treatment is often performed inside locked wards. We investigate the effects of adopting a policy of open-door treatment for a substance use treatment and dual diagnosis ward. METHODS: This is a prospective open-label study investigating 3-month study periods before opening (P1), immediately after (P2), and 1 year after the first period (P3). Data on committed patients, coercion (seclusion, forced medication, absconding events with subsequent police search), violence, and substance use was collected daily...
March 29, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28350567/watchful-waiting-versus-surgery-of-mildly-symptomatic-or-asymptomatic-inguinal-hernia-in-men-aged-50-years-and-older-a-randomized-controlled-trial
#2
Barry de Goede, Arthur R Wijsmuller, Gabrielle H van Ramshorst, Bob J van Kempen, Wim C J Hop, Pieter J Klitsie, Marc R Scheltinga, Jeroen de Haan, Walter J B Mastboom, Erwin van der Harst, Maarten P Simons, Gert-Jan Kleinrensink, Johannes Jeekel, Johan F Lange
OBJECTIVE: To compare if watchful waiting is noninferior to elective repair in men aged 50 years and older with mildly symptomatic or asymptomatic inguinal hernia. BACKGROUND: The role of watchful waiting in older male patients with mildly symptomatic or asymptomatic inguinal hernia is still not well-established. METHODS: In this noninferiority trial, we randomly assigned men aged 50 years and older with mildly symptomatic or asymptomatic inguinal hernia to either elective inguinal hernia repair or watchful waiting...
March 27, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28346955/nonischemic-priapism-in-childhood-a-case-series-and-review-of-literature
#3
Hans-Walter Hacker, Marcus G Schwoebel, Philipp O Szavay
Introduction Nonischemic priapism (NIP) in childhood is a very rare affection. In the literature, patients with NIP are described mainly incidental after perineal trauma. Many of them underwent embolization of either internal pudendal artery or bulbocavernosal arteries. Patients and Methods We report on six boys between 4 and 13 years of age with NIP, treated at our institution between 2008 and 2014. Color Doppler ultrasound (CDU) was performed in all patients as emergency diagnostic evaluation. Patients were treated conservatively, including bed rest, local cooling, and perineal compression...
March 27, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28346951/professionalism-charter-provides-guidance-to-health-care-organizations-in-these-troubled-times
#4
David A Fleming, Walter J McDonald
No abstract text is available yet for this article.
March 28, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28346234/outstanding-animal-studies-in-allergy-i-from-asthma-to-food-allergy-and-anaphylaxis
#5
Erika Jensen-Jarolim, Isabella Pali-Schöll, Franziska Roth-Walter
PURPOSE OF REVIEW: Animal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed. RECENT FINDINGS: While domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results...
March 24, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28345926/band-gap-opening-induced-by-the-structural-periodicity-in-epitaxial-graphene-buffer-layer
#6
Maya Narayanan Nair, Irene Palacio, Arlensiú Celis, Alberto Zobelli, Alexandre Gloter, Stefan Kubsky, Jean-Philippe Turmaud, Matthew Conrad, Claire Berger, Walter de Heer, Edward Henry Conrad, Amina Taleb-Ibrahimi, Antonio Tejeda
The epitaxial graphene buffer layer on the Si face of hexagonal SiC shows a promising band gap, which precise origin remains to be understood. In this work, we correlate the electronic to the atomic structure of the buffer layer by combining angle resolved photoemission spectroscopy (ARPES), scanning tunneling microscopy (STM) and high-resolution scanning transmission electron microscopy (HR-STEM). We show that the band structure in the buffer has an electronic periodicity related to the structural periodicity observed in STM images and published X-ray diffraction...
March 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/28345808/molecular-genetic-analysis-of-the-melanoma-regulatory-locus-in-xiphophorus-interspecies-hybrids
#7
Yuan Lu, Mikki Boswell, William Boswell, Susanne Kneitz, Michael Hausmann, Barbara Klotz, Janine Regneri, Markita Savage, Angel Amores, John Postlethwait, Wesley Warren, Manfred Schartl, Ronald Walter
Development of spontaneous melanoma in Xiphophorus interspecies backcross hybrid progeny, (X. hellerii × [X. maculatus Jp 163 A × X. hellerii]) is due to Mendelian segregation of a oncogene (xmrk) and a molecularly uncharacterized locus, called R(Diff), on LG5. R(Diff) is thought to suppresses the activity of xmrk in healthy X. maculatus Jp 163 A parental species that rarely develop melanoma. To better understand the molecular genetics of R(Diff), we utilized RNA-Seq to study allele-specific gene expression of spontaneous melanoma tumors and corresponding normal skin samples derived from 15 first generation backcross (BC1 ) hybrids and 13 fifth generation (BC5 ) hybrids...
March 27, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28345785/nanog-overexpression-and-its-correlation-with-stem-cell-and-differentiation-markers-in-meningiomas-of-different-who-grades
#8
Diana Freitag, Aaron Lawson McLean, Michèle Simon, Arend Koch, Susanne Grube, Jan Walter, Rolf Kalff, Christian Ewald
NANOG, as a key regulator of pluripotency and acting synergistically with other factors, has been described as a crucial transcription factor in various types of cancer. In meningiomas the expression of this marker has not yet been described. With our study, we aimed to identify and localize Nanog and other possible markers of pluripotency, stem cell properties and differentiation in meningioma tissue, to elucidate a possible effect on tumorigenesis. The gene expression levels of NANOG (NANOG1 and NANOGP8), SOX2, OCT4, KLF4, ABCG2, CMYC, MSI1, CD44, NOTCH1, NES, SALL4B, TP53 and EPAS1 were quantitatively examined using RT-qPCR in 33 surgical specimens of low- (WHO grade I) as well as in atypical and anaplastic (WHO grade II/III) meningiomas with dural tissue as reference...
March 27, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28345372/screening-of-intestinal-crypt-organoids
#9
Svenja Ley, Olaf Galuba, Adrian Salathe, Nicolas Melin, Alexandra Aebi, Monika Pikiolek, Judith Knehr, Walter Carbone, Martin Beibel, Florian Nigsch, Guglielmo Roma, Giovanni d'Ario, Susan Kirkland, Laure C Bouchez, Caroline Gubser Keller, Tewis Bouwmeester, Christian N Parker, Heinz Ruffner
Oral and intestinal mucositis is a debilitating side effect of radiation treatment. A mouse model of radiation-induced mucositis leads to weight loss and tissue damage, reflecting the human ailment as it responds to keratinocyte growth factor (KGF), the standard-of-care treatment. Cultured intestinal crypt organoids allowed the development of an assay monitoring the effect of treatments of intestinal epithelium to radiation-induced damage. This in vitro assay resembles the mouse model as KGF and roof plate-specific spondin-1 (RSPO1) enhanced crypt organoid recovery following radiation...
January 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28344634/an-image-analysis-pipeline-for-automated-classification-of-imaging-light-conditions-and-for-quantification-of-wheat-canopy-cover-time-series-in-field-phenotyping
#10
Kang Yu, Norbert Kirchgessner, Christoph Grieder, Achim Walter, Andreas Hund
BACKGROUND: Robust segmentation of canopy cover (CC) from large amounts of images taken under different illumination/light conditions in the field is essential for high throughput field phenotyping (HTFP). We attempted to address this challenge by evaluating different vegetation indices and segmentation methods for analyzing images taken at varying illuminations throughout the early growth phase of wheat in the field. 40,000 images taken on 350 wheat genotypes in two consecutive years were assessed for this purpose...
2017: Plant Methods
https://www.readbyqxmd.com/read/28344579/reslizumab-and-eosinophilic-asthma-one-step-closer-to-precision-medicine
#11
REVIEW
Gilda Varricchi, Gianenrico Senna, Stefania Loffredo, Diego Bagnasco, Matteo Ferrando, Giorgio Walter Canonica
Human eosinophils represent approximately 1% of peripheral blood leukocytes. However, these cells have the propensity to leave the blood stream and migrate into inflamed tissues. Eosinophilic inflammation is present in a significant proportion of patients with severe asthma. Asthma is a chronic inflammatory disorder that affects more than 315 million people worldwide, with 10% having severe uncontrolled disease. Although the majority of patients can be efficiently treated, severe asthmatics continue to be uncontrolled and are at risk of exacerbations and even death...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28344454/the-effect-of-intermittent-head-cooling-on-aerobic-performance-in-the-heat
#12
Peter Walters, Nathaniel Thom, Kai Libby, Shelby Edgren, Amanda Azadian, Daniel Tannous, Elisabeth Sorenson, Brian Hunt
Thermoregulation is critical for athletes, particularly those for those who must perform in the heat. Most strategies aimed at reducing heat stress have cooled participants before or during activity. The objective of this study is to investigate whether seven minutes of head cooling applied between bouts of aerobic exercise in hot (35 ± 1.0 °C) and dry (14.68 ±4.29% rh) environmental conditions could positively effect participants peak power output (PP) on a maximal effort graded exercise test (GXT). Twenty-two recreational active men ages 18 to 23 (19...
March 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28344370/effectiveness-of-an-intervention-for-children-with-externalizing-behavior-and-mild-to-borderline-intellectual-disabilities-a-randomized-trial
#13
Hilde Schuiringa, Maroesjka van Nieuwenhuijzen, Bram Orobio de Castro, John E Lochman, Walter Matthys
This study evaluated the effectiveness of Standing Strong Together (SST), a combined group based parent and child intervention for externalizing behavior in 9-16 year-old children with mild to borderline intellectual disabilities (MBID). Children with externalizing behavior and MBID (IQ from 55 to 85) (N = 169) were cluster randomly assigned to SST combined with care as usual or to care as usual only. SST led to a significant benefit on teacher reported but not on parent reported externalizing behavior. SST had significant effects on parent rated positive parenting and the parent-child relationship...
2017: Cognitive Therapy and Research
https://www.readbyqxmd.com/read/28344177/multi-modality-multi-directional-resection-of-craniopharyngioma-versatility-in-alternating-the-principal-and-auxiliary-surgical-corridors-and-visualization-modalities
#14
https://www.readbyqxmd.com/read/28343822/the-new-surgical-technique-for-improving-total-knee-and-hip-arthroplasty-outcomes-patient-selection
#15
Kevin Magone, Bernard P Kemker, Nataliya Pilipenko, Erin O'Connor, Norman Walter, Theresa Atkinson
BACKGROUND: Inclusion of patient satisfaction scores in setting reimbursements has been suggested by health care policy makers to contain cost and improve outcomes. The Short Form 36 Health Survey (SF-36) score provides a health-related quality of life (HRQoL) measure of arthroplasty outcome. Although previous work identified factors that influence this score for hip and knee arthroplasty patients, they did not focus on how a surgeon might use this information in a clinical setting. The present study examined whether relatively simple criteria might identify patients more likely to experience minimal HRQoL improvement...
March 1, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28343477/rehabilitation-research-at-the-national-institutes-of-health-moving-the-field-forward-executive-summary
#16
Walter R Frontera, Jonathan F Bean, Diane Damiano, Linda Ehrlich-Jones, Melanie Fried-Oken, Alan Jette, Ranu Jung, Rick L Lieber, James F Malec, Michael J Mueller, Kenneth J Ottenbacher, Keith E Tansey, Aiko Thompson
No abstract text is available yet for this article.
April 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28343370/the-esthetic-and-psychologic-benefits-of-an-intraoperative-provisional-restoration
#17
Robert D Walter, Charles J Goodacre
OBJECTIVE: When multiple visible teeth are prepared, the prolonged treatment time may lead to patients needing a break that requires them to leave the operatory. Such a situation allows the patient to view their prepared teeth, a process that can be disconcerting to some patients. CLINICAL CONSIDERATIONS: An intraoperative provisional restoration can be made by using a thermoplastic vacuum-formed matrix of the patient's teeth that is filled with white-colored impression material and then placed over the prepared teeth to form a provisional restoration...
March 26, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/28343262/cavin-1-deficiency-modifies-myocardial-and-coronary-function-stretch-responses-and-ischaemic-tolerance-roles-of-nos-over-activity
#18
Mika Kaakinen, Melissa E Reichelt, Zhibin Ma, Charles Ferguson, Nick Martel, Enzo R Porrello, James E Hudson, Walter G Thomas, Robert G Parton, John P Headrick
Caveolae and associated cavin and caveolins may govern myocardial function, together with responses to mechanical and ischaemic stresses. Abnormalities in these proteins are also implicated in different cardiovascular disorders. However, specific roles of the cavin-1 protein in cardiac and coronary responses to mechanical/metabolic perturbation remain unclear. We characterised cardiovascular impacts of cavin-1 deficiency, comparing myocardial and coronary phenotypes and responses to stretch and ischaemia-reperfusion in hearts from cavin-1 (+/+) and cavin-1 (-/-) mice...
May 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28343260/urethral-lumen-occlusion-by-artificial-sphincteric-devices-a-computational-biomechanics-approach
#19
Arturo Nicola Natali, Emanuele Luigi Carniel, Chiara Giulia Fontanella, Silvia Todros, Giulia Maria De Benedictis, Maria Angela Cerruto, Walter Artibani
The action induced by artificial sphincteric devices to provide urinary continence is related to the problem of evaluating the interaction between the occlusive cuff and the urethral duct. The intensity and distribution of the force induced within the region of application determine a different occlusion process and potential degradation of the urethral tissue, mostly at the borders of the cuff. This problem is generally considered in the light of clinical and surgical operational experience, while a valid cooperation is established with biomechanical competences by means of experimental and numerical investigation...
March 25, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28343143/impact-of-rivaroxaban-on-point-of-care-assays
#20
Pierre Fontana, Lorenzo Alberio, Anne Angelillo-Scherrer, Lars M Asmis, Wolfgang Korte, Adriana Mendez, Pirmin Schmid, Hans Stricker, Jan-Dirk Studt, Dimitrios A Tsakiris, Walter A Wuillemin, Michael Nagler
BACKGROUND: Point-of-care testing (POCT) is regularly used to assess haemostasis in various clinical settings. The impact of rivaroxaban on those POCT is still elusive. We aimed to study the effects of rivaroxaban on most commonly used POCT assays. METHODS: Blood samples were taken before, 3h, and 24h after administration of 20mg rivaroxaban to 20 healthy volunteers as part of a prospective, multicenter validation study (clinicaltrials.govNCT01710267). Blood samples were analysed with thromboelastometry (ROTEM®), two platelet function assays (INNOVANCE® PFA-200 and Multiplate®), and the CoaguChek® XS...
March 21, 2017: Thrombosis Research
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