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https://www.readbyqxmd.com/read/29343462/a-tailored-web-based-advice-tool-for-skiers-and-snowboarders-protocol-for-a-randomized-controlled-trial
#1
Ellen Kemler, Vincent Gouttebarge
BACKGROUND: Being active in sports has many positive health effects. The direct effects of engaging in regular physical activity are particularly apparent in the prevention of several chronic diseases, including cardiovascular disease, diabetes, cancer, hypertension, obesity, depression, and osteoporosis. Besides the beneficial health effects of being active, sports participation is unfortunately also associated with a risk of injuries. In the case of many sports injuries (eg, winter sports) preventive measures are not compulsory, which means that a behavioral change in sports participants is necessary to increase the use of effective measures, and subsequently prevent or reduce injuries in sports...
January 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29335847/diabetes-obesity-and-the-metabolic-syndrome-as-prognostic-factors-in-stages-i-to-iii-colorectal-cancer-patients
#2
Brianna Croft, Melissa Reed, Caitlyn Patrick, Natalie Kovacevich, Ioannis A Voutsadakis
BACKGROUND: Attempts to introduce prognostic factors for survival outcomes in localized colorectal cancer patients receiving surgical treatment with or without adjuvant therapies, beyond the classic staging parameters, have been met with limited success. Obesity and diabetes mellitus are among the conditions that predispose to colorectal cancer but their value as prognostic markers once the disease is diagnosed is controversial. PATIENTS AND METHODS: This study examines the prognostic value of the components of metabolic syndrome in a retrospective series of colorectal cancer patients with stages I to III disease followed in a single center...
January 15, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29333686/predicting-hypertension-among-korean-cancer-survivors-a-nationwide-population-based-study
#3
Y-H Kim, K-H Cho, K H Kim, E J Ryu, K D Han, J-S Kim
Hypertension is the most common comorbidity among cancer survivors, although there is no model for predicting hypertension in this population. Therefore, we developed a model for predicting hypertension using data from 6,480 Korean cancer survivors who were ≥20 years old. The odds ratios (ORs) for hypertension were calculated using stepwise logistic regression analyses, and a nomogram was generated to predict hypertension. Hypertension was independently associated with an age of ≥65 years (OR: 3.058), male gender (OR: 1...
January 15, 2018: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29286478/a-murine-model-of-vertical-sleeve-gastrectomy
#4
Darline Garibay, Bethany P Cummings
Bariatric surgery, such as vertical sleeve gastrectomy (VSG), is a surgery of the gastrointestinal tract that is performed for the purpose of weight loss. Bariatric surgery is currently the most effective long-term treatment for obesity. In addition to weight loss, bariatric surgery produces additional health benefits such as remission of type 2 diabetes, remission of hypertension, and decreased risk of developing certain types of cancer. The mechanisms beyond weight loss for these benefits remain incompletely defined...
December 18, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29250671/correlation-between-leptin-and-ghrelin-expression-in-adipose-visceral-tissue-and-clinical-biological-features-in-malignant-obesity
#5
Gabriel Verdeş, Ciprian Constantin DuŢă, Roxana Popescu, Mihai MituleŢu, Sorin Ursoniu, Octavian Fulger Lazăr
Morbid obesity is a metabolic disease characterized by an excessive accumulation of adipose tissue (=40%). This disorder is commonly associated with cardiovascular disease, arteriosclerosis, type 2 diabetes, hypothyroidism and some types of cancer. The most common metabolic signals associated with the disease are leptin, ghrelin, with antagonic effects. Our study aimed at highlighting leptin and ghrelin expression levels, as well as establishing correlations between them and clinical-biological parameters in obese patients...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29222878/non-communicable-diseases-food-and-nutrition-in-vietnam-from-1975-to-2015-the-burden-and-national-response
#6
Tuan T Nguyen, Minh V Hoang
BACKGROUND AND OBJECTIVES: This review manuscript examines the burden and national response to non-communicable diseases (NCDs), food and nutrition security in Vietnam from 1975 to 2015. METHODS AND STUDY DESIGN: We extracted data from peer-reviewed manuscripts and reports of nationally representative surveys and related policies in Vietnam. RESULTS: In 2010, NCDs accounted for 318,000 deaths (72% of total deaths), 6.7 million years of life lost, and 14 million disability-adjusted life years in Vietnam...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29207219/-donor-and-recipient-selection-in-living-donor-kidney-transplantation-eligibility
#7
REVIEW
Marilena Gregorini, Eleonora Francesca Pattonieri, Gianluca Fasoli, Mauro Valente, Edoardo La Porta, Michele Canevari, Fulvia Erasmi, Teresa Rampino
This review is intended to be a guide for the physician to evaluate and prepare a donor / recipient couple for living kidney transplantation. Although it is intended to be exhaustive, it will not be able to respond at all possible and different cases, but it may apply at most of them. Renal transplantation is considered the choice treatment for patients with chronic renal failure and if the kidney transplant is performed pre-emptive it is associated with better organ and patient survival. The main aim of the program is to evaluate the risks of donor and recipient and to ensure the donor safety and well-being...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29205099/adiponectin-leptin-ratio-a-promising-index-to-estimate-adipose-tissue-dysfunction-relation-with-obesity-associated-cardiometabolic-risk
#8
Gema Frühbeck, Victoria Catalán, Amaia Rodríguez, Javier Gómez-Ambrosi
Obesity is currently the most extended metabolic disturbance worldwide favoring the development of cardiometabolic alterations such as type 2 diabetes, hypertension, and dyslipidemia. Obesity and the metabolic syndrome (MS) are characterized by an increase in circulating leptin concentrations, in parallel to a decrease in blood levels of adiponectin. Consequently, the adiponectin/leptin ratio has been suggested as a maker of adipose tissue dysfunction. This emerging biomarker correlates with insulin resistance better than adiponectin or leptin alone, or even HOMA and is decreased with increasing number of metabolic risk factors having been proposed as a predictive marker for the MS...
December 5, 2017: Adipocyte
https://www.readbyqxmd.com/read/29190377/european-society-of-cardiology-cardiovascular-disease-statistics-2017
#9
Adam Timmis, Nick Townsend, Chris Gale, Rick Grobbee, Nikos Maniadakis, Marcus Flather, Elizabeth Wilkins, Lucy Wright, Rimke Vos, Jeroen Bax, Maxim Blum, Fausto Pinto, Panos Vardas
Aims: The European Society of Cardiology (ESC) Atlas has been compiled by the European Heart Agency to document cardiovascular disease (CVD) statistics of the 56 ESC member countries. A major aim of this 2017 data presentation has been to compare high-income and middle-income ESC member countries to identify inequalities in disease burden, outcomes, and service provision. Methods and results: The Atlas utilizes a variety of data sources, including the World Health Organization, the Institute for Health Metrics and Evaluation, and the World Bank to document risk factors, prevalence, and mortality of cardiovascular disease and national economic indicators...
November 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29179955/the-utility-of-bedside-simulation-for-training-in-critical-care-obstetrics
#10
REVIEW
Jean-Ju Sheen, Colleen Lee, Dena Goffman
Over the last 2 decades, the maternal mortality ratio in the United States has doubled from 7.4/100,000 live births in 1986 to 14.5/100,000 today. Despite great advances in health care, increasing rates of maternal morbidity and mortality in the United States have prompted calls to action to reverse this disturbing trend. Assisted reproductive technology has allowed women to delay childbearing to more advanced ages, resulting in a greater number of pregnancies complicated by one or more of the diseases associated with aging, such as cardiovascular disease, cancer, type 2 diabetes, and hypertension...
November 24, 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/29178858/measures-of-excess-body-weight-and-anthropometry-among-adult-albertans-cross-sectional-results-from-alberta-s-tomorrow-project-cohort
#11
Darren R Brenner, Abbey E Poirier, Tiffany R Haig, Alianu Akawung, Christine M Friedenreich, Paula J Robson
BACKGROUND: Excess body weight during adulthood has been consistently associated with all-cause mortality, cardiovascular disease, and cancer at multiple sites among other chronic diseases. We describe the prevalence of excess body weight and abdominal obesity reported by participants enrolled in Alberta's Tomorrow Project (ATP). METHODS: ATP is a geographically-based cohort study conducted among adults aged 35-69 years from across the province of Alberta. Participants completed anthropometric measures and health and lifestyle questionnaires at enrolment...
November 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29170059/the-clinical-potential-of-adipogenesis-and-obesity-related-micrornas
#12
REVIEW
M Zaiou, H El Amri, A Bakillah
Obesity is a growing health problem commonly associated with numerous metabolic disorders including type 2 diabetes, hypertension, cardiovascular disease, and some forms of cancer. The burden of obesity and associated cardiometabolic diseases are believed to arise through complex interplay between genetics and epigenetics predisposition, nutrition, environment, and lifestyle. However, the molecular basis and the repertoire of obesity-affecting factors are still unknown. Emerging evidence is connecting microRNAs (miRNAs) dysregulation with adipogenesis and obesity...
November 20, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29165090/inhibition-of-adipogenesis-by-thiourea-derivatives
#13
Hina Siddiqui, Sarah Shafi, Farah Mukhtar, Asma Ejaz, Atta-Ur-Rahman, M Iqbal Choudhary
BACKGROUND: Obesity is one of the major health problem with inherent risk of type 2 diabetes, hypertension, CVDs etc. Adipogenesis is a major contributor in the process of obesity. Inhibition of adipocytes is one of the key approach to treat obesity. OBJECTIVE: To discover the new inhibitors of adipogenesis as the treatment for the obesity. METHOD: We describe here the synthesis and anti-adipogenic activity of thiourea derivatives 1-14. These derivatives were synthesized by the reactions of phenyl and pentafluorophenyl isothiocyanate with different aromatic amines...
November 20, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29138984/11%C3%AE-hydroxysteroid-dehydrogenases-and-hypertension-in-the-metabolic-syndrome
#14
REVIEW
Matthew A Bailey
The metabolic syndrome describes a clustering of risk factors-visceral obesity, dyslipidaemia, insulin resistance, and salt-sensitive hypertension-that increases mortality related to cardiovascular disease, type 2 diabetes, cancer, and non-alcoholic fatty liver disease. The prevalence of these concurrent comorbidities is ~ 25-30% worldwide, and metabolic syndrome therefore presents a significant global public health burden. Evidence from clinical and preclinical studies indicates that glucocorticoid excess is a key causal feature of metabolic syndrome...
November 14, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29122795/association-of-type-2-diabetes-with-in-hospital-complications-among-women-undergoing-breast-cancer-surgical-procedures-a-retrospective-study-using-the-spanish-national-hospital-discharge-database-2013-2014
#15
Ana Lopez-de-Andres, Isabel Jimenez-Trujillo, Valentin Hernandez-Barrera, Javier de Miguel-Diez, Manuel Mendez-Bailon, Jose M de Miguel-Yanes, Napoleon Perez-Farinos, Miguel Angel Salinero-Fort, Jose L Del Barrio, Martin Romero-Maroto, Rodrigo Jimenez-Garcia
OBJECTIVES: To compare the type of surgical procedures used, comorbidities, in-hospital complications (IHC) and in-hospital outcomes between women with type 2 diabetes mellitus (T2DM) and age-matched women without diabetes who were hospitalised with breast cancer. In addition, we sought to identify factors associated with IHC in women with T2DM who had undergone surgical procedures for breast cancer. DESIGN: Retrospective study using the National Hospital Discharge Database, 2013-2014...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29120831/epidemiology-of-areca-betel-nut-use-in-the-mariana-islands-findings-from-the-university-of-guam-university-of-hawai-i-cancer-center-partnership-program
#16
Yvette C Paulino, Eric L Hurwitz, Joanne C Ogo, Tristan C Paulino, Ashley B Yamanaka, Rachel Novotny, Lynne R Wilkens, Mary Jane Miller, Neal A Palafox
BACKGROUND: Areca (betel) nut is considered a Group 1 human carcinogen shown to be associated with other chronic diseases in addition to cancer. This paper describes the areca (betel) nut chewing trend in Guam, and health behaviors of chewers in Guam and Saipan. METHODS: The areca (betel) nut module in the Guam Behavioral Risk Factor Surveillance Survey was used to calculate the 5-year (2011-2015) chewing trend. To assess the association between areca (betel) nut chewing and health risks in the Mariana Islands, a cross-section of 300 chewers, ≥18years old, were recruited from households in Guam and Saipan...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29114188/chronic-disease-prevalence-among-elderly-saudi-men
#17
Nazmus Saquib, Juliann Saquib, Abdulrahman Alhadlag, Mohamad Anas Albakour, Bader Aljumah, Mohammed Sughayyir, Ziad Alhomidan, Omar Alminderej, Mohamed Aljaser, Abdulrahman Al-Mazrou
Objective: Saudi demographic composition has changed because of increased life expectancy and decreased fertility rates. Little data are available about health conditions among older adults in Saudi Arabia, who are expected to represent 20% of the population by 2050. The study aim was to assess the prevalence and risk factors for chronic conditions among older Saudi men. Methods: The sample pertained to 400 men (age ≥55 years) from Buraidah, Al-Qassim. Research assistants recruited participants in all the mosques from the randomly selected neighborhoods (16 of 95)...
November 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29108205/-investigation-and-analysis-of-the-knowledge-of-nonalcoholic-fatty-liver-disease-among-residents-in-hebei-province-china
#18
Q F Liang, Y D Wang, C Y Zhao
Objective: To investigate the knowledge of nonalcoholic fatty liver disease (NAFLD) among medical staff and general population in Hebei Province, China, understand the degree of awareness of NAFLD among residents, standardize the diagnosis and treatment of NAFLD, improve the correct awareness of NAFLD among general population, promote the establishment of a reasonable lifestyle, and scientifically and effectively control the incidence and mortality rates of NAFLD. Methods: The investigation was performed in 30 hospitals and neighboring schools and communities in Hebei Province, and a questionnaire survey on the knowledge of NAFLD was performed for 1 300 medical workers and 2 000 persons from the general population...
October 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29063071/novel-strategies-halt-cardiovascular-diabetes-and-cancer-strips
#19
REVIEW
Chun-Song Hu, Qing-Hua Wu, Da-Yi Hu, Tengiz Tkebuchava
In this article, we introduce briefly several strategies for preventing atherosclerotic cardiovascular disease and promoting healthcare for non-communicable diseases (NCDs). These novel strategies include four core elements of health - sleep, emotion, exercise, and diet - and consist of SEED intervention (SEEDi) and E(e)SEEDi due to supplementation of the environment as a core element, and Hu's healthy lifestyles intervention (HHLi) which originates from E(e)SEED-BasED healthy lifestyles. They are suitable for the early evaluation of risk factors, and play a key role in the prevention and management of human NCDs when combined with the RT-ABCDEF strategy and the Grade 210 prevention, which include obesity-OSA-hypertension syndrome and C-type hypertension, especially in halting cardiovascular, diabetes and cancer (CDC) strips we first discovered...
September 2017: Chronic Diseases and Translational Medicine
https://www.readbyqxmd.com/read/29044635/development-and-application-of-a-real-time-polymerase-chain-reaction-assay-for-detection-of-a-novel-gut-bacteriophage-crassphage
#20
Yuying Liang, Xin Jin, Yuan Huang, Shuiping Chen
BACKGROUND: crAssphage is a novel and by far the most abundant bacteriophage in human gut. This bacteriophage might modulate gut microbiota balance so as to be involved in some diseases like obesity, diabetes, metabolic disorders, hypertension, and cancer. Therefore, a rapid and reliable detection and quantification method for crAssphage is essential for studying its molecular epidemiology and pathogenicity in human diseases. MATERIALS AND METHODS: The primers-probes set for the quantitative real-time PCR assay was designed based on the DNA polymerase gene (ORF00018) of crAssphage...
October 16, 2017: Journal of Medical Virology
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