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Intrauterine asphyxia

Gavino Faa, Mirko Manchia, Roberta Pintus, Clara Gerosa, Maria Antonietta Marcialis, Vassilios Fanos
Starting from the Developmental Origins of Health and Disease (DOHaD) hypotheses proposed by David Barker, namely fetal programming, in the past years, there is a growing evidence of the major role played by epigenetic factors during the intrauterine life and the perinatal period. Furthermore, it has been assessed that these factors can affect the health status in infancy and even in adulthood. In this review, we focus our attention on the fetal programming of the brain, analyzing the most recent literature concerning the epigenetic factors that can influence the development of neuropsychiatric disorders such as bipolar disorders, major depressive disorders, and schizophrenia...
October 24, 2016: Birth Defects Research. Part C, Embryo Today: Reviews
Kathryn J Sharma, Tania F Esakoff, Alyson Guillet, Richard M Burwick, Aaron B Caughey
OBJECTIVE: To determine whether adverse outcomes were more common in late preterm pregnancies complicated by preeclampsia and growth restriction compared to those affected by preeclampsia alone. METHODS: This was a retrospective cohort study of 8,927 singleton pregnancies with preeclampsia. Pregnancies with small for gestational age (SGA) neonates (birthweight <10(th) percentile) were compared to those appropriate for gestational age (AGA) neonates. Maternal outcomes included cesarean delivery (CD) rate, CD for fetal heart rate (FHR) abnormalities, abruption, postpartum hemorrhage (PPH), maternal transfusion, acute renal failure, and peripartum cardiomyopathy...
October 19, 2016: Journal of Maternal-fetal & Neonatal Medicine
Jens Henrichs, Viki Verfaille, Laura Viester, Myrte Westerneng, Bert Molewijk, Arie Franx, Henriette van der Horst, Judith E Bosmans, Ank de Jonge, Petra Jellema
BACKGROUND: Intrauterine growth retardation (IUGR) is a major risk factor for perinatal mortality and morbidity. Thus, there is a compelling need to introduce sensitive measures to detect IUGR fetuses. Routine third trimester ultrasonography is increasingly used to detect IUGR. However, we lack evidence for its clinical effectiveness and cost-effectiveness and information on ethical considerations of additional third trimester ultrasonography. This nationwide stepped wedge cluster-randomized trial examines the (cost-)effectiveness of routine third trimester ultrasonography in reducing severe adverse perinatal outcome through subsequent protocolized management...
October 13, 2016: BMC Pregnancy and Childbirth
Ellie Wernham, Jason Gurney, James Stanley, Lis Ellison-Loschmann, Diana Sarfati
BACKGROUND: Internationally, a typical model of maternity care is a medically led system with varying levels of midwifery input. New Zealand has a midwife-led model of care, and there are movements in other countries to adopt such a system. There is a paucity of systemic evaluation that formally investigates safety-related outcomes in relationship to midwife-led care within an entire maternity service. The main objective of this study was to compare major adverse perinatal outcomes between midwife-led and medical-led maternity care in New Zealand...
September 2016: PLoS Medicine
Richa Gangwar, Sarita Chaudhary
BACKGROUND: The main documented indication of intrapartum caesarean section is foetal distress (MacKenzie and Cooke in BMJ 323(7318):930, 2001). Foetal distress indicates foetal hypoxia and acidosis during intrauterine life. PURPOSE: To correlate the diagnosis of foetal distress and perinatal outcome. METHODS: This was a prospective observational study of women who underwent caesarean section for foetal distress as detected by cardiotocography and not responding to intrauterine resuscitation...
October 2016: Journal of Obstetrics and Gynaecology of India
E Pirnareva, M Tsankova
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Christina A Herrera, Robert M Silver
Perinatal asphyxia is a general term referring to neonatal encephalopathy related to events during birth. Asphyxia refers to a deprivation of oxygen for a duration sufficient to cause neurologic injury. Most cases of perinatal asphyxia are not necessarily caused by intrapartum events but rather associated with underlying chronic maternal or fetal conditions. Of intrapartum causes, obstetric emergencies are the most common and are not always preventable. Screening high-risk pregnancies with ultrasound, Doppler velocimetry, and antenatal testing can aid in identifying fetuses at risk...
September 2016: Clinics in Perinatology
Sarah U Morton, Dara Brodsky
The physiology of the fetus is fundamentally different from the neonate, with both structural and functional distinctions. The fetus is well-adapted to the relatively hypoxemic intrauterine environment. The transition from intrauterine to extrauterine life requires rapid, complex, and well-orchestrated steps to ensure neonatal survival. This article explains the intrauterine physiology that allows the fetus to survive and then reviews the physiologic changes that occur during the transition to extrauterine life...
September 2016: Clinics in Perinatology
Kattiya Manomayangkul, Arunotai Siriussawakul, Akarin Nimmannit, Thassayu Yuyen, Sopapan Ngerncham, Kanit Reesukumal
BACKGROUND: Umbilical cord blood gas values are better indicators of perinatal asphyxia than Apgar scores. Many studies have reported normal ranges of umbilical cord blood gases, which vary greatly due to many factors. This study aimed to establish the reference values of umbilical cord blood gases of normal cesarean newborns in a university hospital setting. MATERIAL AND METHOD: Blood samples from the umbilical artery and vein were collected from 160 newborns delivered by elective cesarean section...
May 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Deepak Sharma, Sweta Shastri, Pradeep Sharma
Intrauterine growth restriction (IUGR), a condition that occurs due to various reasons, is an important cause of fetal and neonatal morbidity and mortality. It has been defined as a rate of fetal growth that is less than normal in light of the growth potential of that specific infant. Usually, IUGR and small for gestational age (SGA) are used interchangeably in literature, even though there exist minute differences between them. SGA has been defined as having birth weight less than two standard deviations below the mean or less than the 10th percentile of a population-specific birth weight for specific gestational age...
2016: Clinical Medicine Insights. Pediatrics
I V Boronina, I V Shaposhnikova, D S Stepanov, L S Oshanova, A F Neretina
AIM: to study the nosological structure of mortality among fetuses with a birth weight of less than 1000 g in the Voronezh region in the periods 2010-2011 and 2013-2014. MATERIAL AND METHODS: A total of 267 autopsy protocols were analyzed in fetuses with a birth weight of less than 1000 g in the period 2010-2011 and 2013-2014. RESULTS: Spontaneous abortion happened in 81 (30.3%) cases, artificial one did in 186 (69.7%). The most common cause of stillbirth among extremely low weight fetuses was intrauterine asphyxia with a preponderance of antenatal asphyxia...
May 2016: Arkhiv Patologii
I Nikitina, V Boykо, T Babar, N Kalashnik, A Yezhova
The clinical analysis of multiple pregnancies. The features of neonatal adaptation process in 96 twins, depending on the type of zygosity. It is proved that the adaptation of the newborn with multiple pregnancy depends on the type of placentation. It is found that monozygotic twins is a risk factor syndromes disadaptation. Children from monozygotic twins compared with dizygotic twins have a higher frequency of the syndrome of respiratory disorders, and more prone to jaundice, hemorrhagic syndrome, violation gemolikvorodinamics II and III degrees...
April 2016: Georgian Medical News
Antonio Noto, Vassilios Fanos, Angelica Dessì
Metabolomics is the quantitative analysis of a large number of low molecular weight metabolites that are intermediate or final products of all the metabolic pathways in a living organism. Any metabolic profiles detectable in a human biological fluid are caused by the interaction between gene expression and the environment. The metabolomics approach offers the possibility to identify variations in metabolite profile that can be used to discriminate disease. This is particularly important for neonatal and pediatric studies especially for severe ill patient diagnosis and early identification...
2016: Advances in Clinical Chemistry
Y Y Zheng, L Y Zou, L Fan
OBJECTIVE: To study the changes of intrapartum cesarean rate, cesarean indications and pregnancy outcomes after the new partogram applied. METHODS: Totally 3 290 pregnant women trying to vaginal delivery which were managed according to the new partogram in Beijing Obstetrics and Gynecology Hospital, Capital Medical University from August to October in 2014(new partogram group)were involved; 2 987 pregnancy women trying to vaginal delivery from May to July in 2014 which were managed according to the old partogram(old partogram group)were involved as control...
April 25, 2016: Zhonghua Fu Chan Ke za Zhi
Deepak Sharma, Nazanin Farahbakhsh, Sweta Shastri, Pradeep Sharma
Small for gestational age (SGA) infants have been classically defined as having birth weight less than two standard deviations below the mean or less than the 10th percentile of a population-specific birth weight for specific gestational age, whereas intrauterine growth restriction (IUGR) has been defined as a rate of foetal growth that is less than normal for the population and for the growth potential of a specific infant. SGA infants have more frequent problems such as perinatal asphyxia, hypothermia, hypoglycaemia, polycythaemia and many more when compared with their appropriate for gestational age counterpart...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
Angie C Jelin, Rita Sharshiner, Aaron B Caughey
OBJECTIVE: To evaluate maternal co-morbidities and adverse perinatal outcomes associated with cystic fibrosis (CF). METHODS: This is a retrospective cohort study of 2 178 954 singleton pregnancies at ≥20 weeks' gestation with and without CF in the state of California during the years 2005-2008. ICD-9 codes and linked hospital discharge and vital statistics data were utilized. Rates of maternal co-morbidities, fetal congenital anomalies and adverse perinatal outcomes were compared in those with CF and those without...
April 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
Xueyan Wang, Chao Zhang, Meiying Liang, Xiaohong Zhang, Jianliu Wang, Xia Zhang
OBJECTIVE: To explore the pregnancy outcomes of women with pancytopenia and the risk factors for the adverse perinatal outcomes. METHODS: A total of 106 pregnant women with pancytopenia were admitted to Peking University People's Hospital from Jan. 2005 to Sep. 2014. The clinical data and the pregnancy outcomes were reviewed retrospectively to investigate the risk factors for the adverse perinatal outcomes. RESULTS: (1 ) Eighty-four patients were found pancytopenia before pregnancy while 22 were found for the first time during pregnancy...
December 2015: Zhonghua Fu Chan Ke za Zhi
Anuja Abraham, Swati Rathore, Mayank Gupta, Santosh Joseph Benjamin
Still birth continues to be one of the many challenges that an obstetrician has to face. Still births that occur in the antenatal period are more difficult to explain than that which occurs intrapartum. The latter is most often due to intrapartum asphyxia, medical complications or infections; however a cause for antenatal still birth is difficult to ascertain. A thorough examination of the case along with necessary investigations might not necessarily reveal any cause and this leads to considerable anxiety for both the mother and the treating obstetrician...
December 2015: Journal of Clinical and Diagnostic Research: JCDR
C Durousset, C Gay, S Magnin, C Acquaviva, H Patural
Neonatal seizure incidence is approximately 3.5/1000 live births. Inborn metabolic diseases account for approximately 1-4% of neonatal seizure cases. Among them, the catabolism anomaly of sulfite to sulfate caused by sulfite oxidase or cofactor molybdenum deficiency (MoCD) is a rare metabolic disorder in which neurological damage is similar to that found in neonatal asphyxia. We report the case of a newborn child with a MoCD. Born of related parents, this child had intrauterine growth retardation predominating on size diagnosed in the third trimester of pregnancy...
March 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Tanja Lazić Mitrović, Željko Miković, Vesna Mandić, Lidija Hajnal Avramović, Djurdjica Ćećez, Aleksandar Stanimirović, Borisav Janković
INTRODUCTION: Neonatal abstinence syndrome (NAS) refers to a newborn neurological, gastrointestinal and/or respiratory disorder if a newborn was exposed to psychoactive substances in the intrauterine period. NAS is difficult to diagnose due to unreliability of the data on addictive substances use during pregnancy, limited possibilities of the prenatal exposure diagnosis and postnatal substance detection, which all lead to diagnostic dilemmas. OBJECTIVE: The aim of this study was to indicate the problems in patients with early NAS diagnosis in the maternity ward and the importance of clinical presentation used as a guide toward the diagnosis...
September 2015: Srpski Arhiv za Celokupno Lekarstvo
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