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Poly I:C

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https://www.readbyqxmd.com/read/29924890/targeting-mmp-13-in-bronchial-epithelial-repair
#1
Christopher Howell, James R Smith, Janis K Shute
BACKGROUND: Viral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial cells to cover denuded areas, followed by proliferation and differentiation. OBJECTIVE: The objective was to test the hypothesis that poly I:C, a model of viral infection, limits epithelial repair through the stimulated release of matrix metalloproteinase-13 (MMP-13)...
June 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29924594/dyed-poly-styrene-methyl-methacrylate-acrylic-acid-photonic-nanocrystals-for-enhanced-structural-color
#2
Gonul Yavuz, Helena P Felgueiras, Ana Isabel Ribeiro, Necdet Seventekin, Andrea Zille, Antonio Pedro Souto
In the present work, we investigated the combined effect of poly (styrene-methyl methacrylate-acrylic acid) [P(St-MMA-AA)] PCs with the disperse dye C.I. Disperse Red 343, on the photonic crystals (PCs) shape, distribution, organization, iridescence, chemical structure, thermal stability and reflectance. PCs were successfully produced in the form of highly spherical, monodisperse colloidal structures. Presence of dye in the PCs inner core-shell structure was confirmed via Fourier-transformed infrared spectroscopy...
June 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29911156/complete-genome-sequencing-of-banana-bract-mosaic-virus-isolate-infecting-cardamom-revealed-its-closeness-to-banana-infecting-isolate-from-india
#3
A I Bhat, N S Pamitha, A Gopika, C N Biju
The complete genome of banana bract mosaic virus (BBrMV), a Potyvirus belonging to the family Potyviridae causing chlorotic streak disease of cardamom ( Elettaria cardamomum ) in India was determined for the first time from a naturally infected cardamom var. Njallani Green Gold through reverse transcription PCR using nine sets of primers designed to different overlapping regions of the genome. The complete genome has 9708 nucleotides excluding poly (A) tail and has the genome organization similar to that of BBrMV isolates infecting banana and flowering ginger ( Alpinia purpurata )...
June 2018: Virusdisease
https://www.readbyqxmd.com/read/29906142/evidence-for-the-rare-decay-%C3%AE-%C3%A2-p%C3%AE-%C3%AE
#4
R Aaij, B Adeva, M Adinolfi, Z Ajaltouni, S Akar, J Albrecht, F Alessio, M Alexander, A Alfonso Albero, S Ali, G Alkhazov, P Alvarez Cartelle, A A Alves, S Amato, S Amerio, Y Amhis, L An, L Anderlini, G Andreassi, M Andreotti, J E Andrews, R B Appleby, F Archilli, P d'Argent, J Arnau Romeu, A Artamonov, M Artuso, E Aslanides, M Atzeni, G Auriemma, M Baalouch, I Babuschkin, S Bachmann, J J Back, A Badalov, C Baesso, S Baker, V Balagura, W Baldini, A Baranov, R J Barlow, C Barschel, S Barsuk, W Barter, F Baryshnikov, V Batozskaya, V Battista, A Bay, L Beaucourt, J Beddow, F Bedeschi, I Bediaga, A Beiter, L J Bel, N Beliy, V Bellee, N Belloli, K Belous, I Belyaev, E Ben-Haim, G Bencivenni, S Benson, S Beranek, A Berezhnoy, R Bernet, D Berninghoff, E Bertholet, A Bertolin, C Betancourt, F Betti, M O Bettler, M van Beuzekom, Ia Bezshyiko, S Bifani, P Billoir, A Birnkraut, A Bizzeti, M Bjørn, T Blake, F Blanc, S Blusk, V Bocci, T Boettcher, A Bondar, N Bondar, I Bordyuzhin, S Borghi, M Borisyak, M Borsato, F Bossu, M Boubdir, T J V Bowcock, E Bowen, C Bozzi, S Braun, J Brodzicka, D Brundu, E Buchanan, C Burr, A Bursche, J Buytaert, W Byczynski, S Cadeddu, H Cai, R Calabrese, R Calladine, M Calvi, M Calvo Gomez, A Camboni, P Campana, D H Campora Perez, L Capriotti, A Carbone, G Carboni, R Cardinale, A Cardini, P Carniti, L Carson, K Carvalho Akiba, G Casse, L Cassina, M Cattaneo, G Cavallero, R Cenci, D Chamont, M G Chapman, M Charles, Ph Charpentier, G Chatzikonstantinidis, M Chefdeville, S Chen, S F Cheung, S-G Chitic, V Chobanova, M Chrzaszcz, A Chubykin, P Ciambrone, X Cid Vidal, G Ciezarek, P E L Clarke, M Clemencic, H V Cliff, J Closier, V Coco, J Cogan, E Cogneras, V Cogoni, L Cojocariu, P Collins, T Colombo, A Comerma-Montells, A Contu, G Coombs, S Coquereau, G Corti, M Corvo, C M Costa Sobral, B Couturier, G A Cowan, D C Craik, A Crocombe, M Cruz Torres, R Currie, C D'Ambrosio, F Da Cunha Marinho, C L Da Silva, E Dall'Occo, J Dalseno, A Davis, O De Aguiar Francisco, K De Bruyn, S De Capua, M De Cian, J M De Miranda, L De Paula, M De Serio, P De Simone, C T Dean, D Decamp, L Del Buono, H-P Dembinski, M Demmer, A Dendek, D Derkach, O Deschamps, F Dettori, B Dey, A Di Canto, P Di Nezza, H Dijkstra, F Dordei, M Dorigo, A Dosil Suárez, L Douglas, A Dovbnya, K Dreimanis, L Dufour, G Dujany, P Durante, J M Durham, D Dutta, R Dzhelyadin, M Dziewiecki, A Dziurda, A Dzyuba, S Easo, U Egede, V Egorychev, S Eidelman, S Eisenhardt, U Eitschberger, R Ekelhof, L Eklund, S Ely, S Esen, H M Evans, T Evans, A Falabella, N Farley, S Farry, D Fazzini, L Federici, D Ferguson, G Fernandez, P Fernandez Declara, A Fernandez Prieto, F Ferrari, L Ferreira Lopes, F Ferreira Rodrigues, M Ferro-Luzzi, S Filippov, R A Fini, M Fiorini, M Firlej, C Fitzpatrick, T Fiutowski, F Fleuret, M Fontana, F Fontanelli, R Forty, V Franco Lima, M Frank, C Frei, J Fu, W Funk, E Furfaro, C Färber, E Gabriel, A Gallas Torreira, D Galli, S Gallorini, S Gambetta, M Gandelman, P Gandini, Y Gao, L M Garcia Martin, J García Pardiñas, J Garra Tico, L Garrido, D Gascon, C Gaspar, L Gavardi, G Gazzoni, D Gerick, E Gersabeck, M Gersabeck, T Gershon, Ph Ghez, S Gianì, V Gibson, O G Girard, L Giubega, K Gizdov, V V Gligorov, D Golubkov, A Golutvin, A Gomes, I V Gorelov, C Gotti, E Govorkova, J P Grabowski, R Graciani Diaz, L A Granado Cardoso, E Graugés, E Graverini, G Graziani, A Grecu, R Greim, P Griffith, L Grillo, L Gruber, B R Gruberg Cazon, O Grünberg, E Gushchin, Yu Guz, T Gys, C Göbel, T Hadavizadeh, C Hadjivasiliou, G Haefeli, C Haen, S C Haines, B Hamilton, X Han, T H Hancock, S Hansmann-Menzemer, N Harnew, S T Harnew, C Hasse, M Hatch, J He, M Hecker, K Heinicke, A Heister, K Hennessy, P Henrard, L Henry, E van Herwijnen, M Heß, A Hicheur, D Hill, P H Hopchev, W Hu, W Huang, Z C Huard, W Hulsbergen, T Humair, M Hushchyn, D Hutchcroft, P Ibis, M Idzik, P Ilten, R Jacobsson, J Jalocha, E Jans, A Jawahery, F Jiang, M John, D Johnson, C R Jones, C Joram, B Jost, N Jurik, S Kandybei, M Karacson, J M Kariuki, S Karodia, N Kazeev, M Kecke, F Keizer, M Kelsey, M Kenzie, T Ketel, E Khairullin, B Khanji, C Khurewathanakul, K E Kim, T Kirn, S Klaver, K Klimaszewski, T Klimkovich, S Koliiev, M Kolpin, R Kopecna, P Koppenburg, A Kosmyntseva, S Kotriakhova, M Kozeiha, L Kravchuk, M Kreps, F Kress, P Krokovny, W Krzemien, W Kucewicz, M Kucharczyk, V Kudryavtsev, A K Kuonen, T Kvaratskheliya, D Lacarrere, G Lafferty, A Lai, G Lanfranchi, C Langenbruch, T Latham, C Lazzeroni, R Le Gac, A Leflat, J Lefrançois, R Lefèvre, F Lemaitre, E Lemos Cid, O Leroy, T Lesiak, B Leverington, P-R Li, T Li, Y Li, Z Li, X Liang, T Likhomanenko, R Lindner, F Lionetto, V Lisovskyi, X Liu, D Loh, A Loi, I Longstaff, J H Lopes, D Lucchesi, M Lucio Martinez, H Luo, A Lupato, E Luppi, O Lupton, A Lusiani, X Lyu, F Machefert, F Maciuc, V Macko, P Mackowiak, S Maddrell-Mander, O Maev, K Maguire, D Maisuzenko, M W Majewski, S Malde, B Malecki, A Malinin, T Maltsev, G Manca, G Mancinelli, D Marangotto, J Maratas, J F Marchand, U Marconi, C Marin Benito, M Marinangeli, P Marino, J Marks, G Martellotti, M Martin, M Martinelli, D Martinez Santos, F Martinez Vidal, A Massafferri, R Matev, A Mathad, Z Mathe, C Matteuzzi, A Mauri, E Maurice, B Maurin, A Mazurov, M McCann, A McNab, R McNulty, J V Mead, B Meadows, C Meaux, F Meier, N Meinert, D Melnychuk, M Merk, A Merli, E Michielin, D A Milanes, E Millard, M-N Minard, L Minzoni, D S Mitzel, A Mogini, J Molina Rodriguez, T Mombächer, I A Monroy, S Monteil, M Morandin, M J Morello, O Morgunova, J Moron, A B Morris, R Mountain, F Muheim, M Mulder, D Müller, J Müller, K Müller, V Müller, P Naik, T Nakada, R Nandakumar, A Nandi, I Nasteva, M Needham, N Neri, S Neubert, N Neufeld, M Neuner, T D Nguyen, C Nguyen-Mau, S Nieswand, R Niet, N Nikitin, T Nikodem, A Nogay, D P O'Hanlon, A Oblakowska-Mucha, V Obraztsov, S Ogilvy, R Oldeman, C J G Onderwater, A Ossowska, J M Otalora Goicochea, P Owen, A Oyanguren, P R Pais, A Palano, M Palutan, G Panshin, A Papanestis, M Pappagallo, L L Pappalardo, W Parker, C Parkes, G Passaleva, A Pastore, M Patel, C Patrignani, A Pearce, A Pellegrino, G Penso, M Pepe Altarelli, S Perazzini, D Pereima, P Perret, L Pescatore, K Petridis, A Petrolini, A Petrov, M Petruzzo, E Picatoste Olloqui, B Pietrzyk, G Pietrzyk, M Pikies, D Pinci, F Pisani, A Pistone, A Piucci, V Placinta, S Playfer, M Plo Casasus, F Polci, M Poli Lener, A Poluektov, I Polyakov, E Polycarpo, G J Pomery, S Ponce, A Popov, D Popov, S Poslavskii, C Potterat, E Price, J Prisciandaro, C Prouve, V Pugatch, A Puig Navarro, H Pullen, G Punzi, W Qian, J Qin, R Quagliani, B Quintana, B Rachwal, J H Rademacker, M Rama, M Ramos Pernas, M S Rangel, I Raniuk, F Ratnikov, G Raven, M Ravonel Salzgeber, M Reboud, F Redi, S Reichert, A C Dos Reis, C Remon Alepuz, V Renaudin, S Ricciardi, S Richards, M Rihl, K Rinnert, P Robbe, A Robert, A B Rodrigues, E Rodrigues, J A Rodriguez Lopez, A Rogozhnikov, S Roiser, A Rollings, V Romanovskiy, A Romero Vidal, M Rotondo, M S Rudolph, T Ruf, P Ruiz Valls, J Ruiz Vidal, J J Saborido Silva, E Sadykhov, N Sagidova, B Saitta, V Salustino Guimaraes, C Sanchez Mayordomo, B Sanmartin Sedes, R Santacesaria, C Santamarina Rios, M Santimaria, E Santovetti, G Sarpis, A Sarti, C Satriano, A Satta, D M Saunders, D Savrina, S Schael, M Schellenberg, M Schiller, H Schindler, M Schmelling, T Schmelzer, B Schmidt, O Schneider, A Schopper, H F Schreiner, M Schubiger, M H Schune, R Schwemmer, B Sciascia, A Sciubba, A Semennikov, E S Sepulveda, A Sergi, N Serra, J Serrano, L Sestini, P Seyfert, M Shapkin, Y Shcheglov, T Shears, L Shekhtman, V Shevchenko, B G Siddi, R Silva Coutinho, L Silva de Oliveira, G Simi, S Simone, M Sirendi, N Skidmore, T Skwarnicki, I T Smith, J Smith, M Smith, L Soares Lavra, M D Sokoloff, F J P Soler, B Souza De Paula, B Spaan, P Spradlin, F Stagni, M Stahl, S Stahl, P Stefko, S Stefkova, O Steinkamp, S Stemmle, O Stenyakin, M Stepanova, H Stevens, S Stone, B Storaci, S Stracka, M E Stramaglia, M Straticiuc, U Straumann, S Strokov, J Sun, L Sun, K Swientek, V Syropoulos, T Szumlak, M Szymanski, S T'Jampens, A Tayduganov, T Tekampe, G Tellarini, F Teubert, E Thomas, J van Tilburg, M J Tilley, V Tisserand, M Tobin, S Tolk, L Tomassetti, D Tonelli, R Tourinho Jadallah Aoude, E Tournefier, M Traill, M T Tran, M Tresch, A Trisovic, A Tsaregorodtsev, P Tsopelas, A Tully, N Tuning, A Ukleja, A Usachov, A Ustyuzhanin, U Uwer, C Vacca, A Vagner, V Vagnoni, A Valassi, S Valat, G Valenti, R Vazquez Gomez, P Vazquez Regueiro, S Vecchi, M van Veghel, J J Velthuis, M Veltri, G Veneziano, A Venkateswaran, T A Verlage, M Vernet, M Vesterinen, J V Viana Barbosa, D Vieira, M Vieites Diaz, H Viemann, X Vilasis-Cardona, M Vitti, V Volkov, A Vollhardt, B Voneki, A Vorobyev, V Vorobyev, C Voß, J A de Vries, C Vázquez Sierra, R Waldi, J Walsh, J Wang, Y Wang, D R Ward, H M Wark, N K Watson, D Websdale, A Weiden, C Weisser, M Whitehead, J Wicht, G Wilkinson, M Wilkinson, M Williams, M Williams, T Williams, F F Wilson, J Wimberley, M Winn, J Wishahi, W Wislicki, M Witek, G Wormser, S A Wotton, K Wyllie, Y Xie, M Xu, Q Xu, Z Xu, Z Xu, Z Yang, Z Yang, Y Yao, H Yin, J Yu, X Yuan, O Yushchenko, K A Zarebski, M Zavertyaev, L Zhang, Y Zhang, A Zhelezov, Y Zheng, X Zhu, V Zhukov, J B Zonneveld, S Zucchelli
A search for the rare decay Σ^{+}→pμ^{+}μ^{-} is performed using pp collision data recorded by the LHCb experiment at center-of-mass energies sqrt[s]=7 and 8 TeV, corresponding to an integrated luminosity of 3  fb^{-1}. An excess of events is observed with respect to the background expectation, with a signal significance of 4.1 standard deviations. No significant structure is observed in the dimuon invariant mass distribution, in contrast with a previous result from the HyperCP experiment. The measured Σ^{+}→pμ^{+}μ^{-} branching fraction is (2...
June 1, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29897527/transdiagnostic-risk-calculator-for-the-automatic-detection-of-individuals-at-risk-and-the-prediction-of-psychosis-second-replication-in-an-independent-national-health-service-trust
#5
Paolo Fusar-Poli, Nomi Werbeloff, Grazia Rutigliano, Dominic Oliver, Cathy Davies, Daniel Stahl, Philip McGuire, David Osborn
Background: The benefits of indicated primary prevention among individuals at Clinical High Risk for Psychosis (CHR-P) are limited by the difficulty in detecting these individuals. To overcome this problem, a transdiagnostic, clinically based, individualized risk calculator has recently been developed and subjected to a first external validation in 2 different catchment areas of the South London and Maudsley (SLaM) NHS Trust. Methods: Second external validation of real world, real-time electronic clinical register-based cohort study...
June 12, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29894863/against-nf-%C3%AE%C2%BAb-thymic-stromal-lymphopoietin-signaling-pathway-catechin-alleviates-the-inflammation-in-allergic-rhinitis
#6
Zengfeng Pan, Yuan Zhou, Xia Luo, Yan Ruan, Lian Zhou, Qing Wang, Ya Jie Yan, Qi Liu, Jinyan Chen
BACKGROUND: The prevalence of allergic rhinitis has risen sharply. Previous work has demonstrated the anti-inflammatory effect of catechin, including in models of allergic disease. However, the molecular mechanisms underlying this therapeutic effect remain unclear. Thymic stromal lymphopoietin(TSLP), as a molecule from epithelial cell, has been identified that plays a significant role in the development of allergic disease, and the production of TSLP is related to activation of the NF-κB signaling pathway...
June 8, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29892949/identification-and-characterization-of-a-novel-goose-type-and-chicken-type-lysozyme-genes-in-chinese-rare-minnow-gobiocypris-rarus-with-potent-antimicrobial-activity
#7
Yingying Zhang, Hui Yang, Weijia Song, Dan Cui, Lixin Wang
Lysozymes act as important innate immunity molecule against various pathogen infections. In the present study, a new c-type and g-type lysozymes were isolated from rare minnow Gobiocypris rarus. The deduced amino acid sequence of c-type lysozyme contained 145 residues and possessed conserved catalytic residues (Glu53 and Asp72 ). The deduced g-type lysozyme contained 185 residues and possessed three conserved catalytic residues (Glu73 , Asp86 and Asp97 ). qPCR analysis revealed that GrlysG and GrlysC were constitutively expressed in all examined tissues...
June 2018: Genes & Genomics
https://www.readbyqxmd.com/read/29890217/a-novel-caspase-6-from-sea-cucumber-holothuria-leucospilota-molecular-characterization-expression-analysis-and-apoptosis-detection
#8
Aifen Yan, Chunhua Ren, Ting Chen, Da Huo, Xiao Jiang, Hongyan Sun, Chaoqun Hu
In this study, a novel caspase-6 named HLcaspase-6 was identified from sea cucumber Holothuria leucospilota. The full-length cDNA of HLcaspase-6 is 2195 bp in size, containing a 126 bp 5'-untranslated region (UTR), a 1043 bp 3'-UTR and a 1026 bp open reading frame (ORF) encoding a protein of 341 amino acids with a deduced molecular weight of 38.57 kDa. HLcaspase-6 contains the common signatures of the caspase family, including the conserved pentapeptide motif QACRG, as well as the P20 and P10 domains. In addition, HLcaspase-6 contains a short pro-domain...
June 8, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29886136/activated-grass-carp-stat6-up-regulates-the-transcriptional-level-and-expression-of-ccl20-and-bcl-xl
#9
Xiaoqin Ran, Changxin Liu, Panwei Weng, Xiaowen Xu, Gang Lin, Guoqin Qi, Ningli Yu, Kang Xu, Zhen Wu, Chengyu Hu
In mammals, signal transducer and activator of transcription 6 (STAT6) is a broad-spectrum transcriptional regulator involved in cellular immune responses and apoptosis by regulating the immune-related genes and various functional genes. The structure, expression and tyrosine-based phosphorylation of STAT6 are conserved from fish to mammal. However, except the sporadic reports from zebra fish, the function of fish STAT6 has not been well reported. Here, we cloned and characterized the full length cDNA sequence of grass carp (Ctenopharyngodon idella) STAT6 (CiSTAT6)...
June 7, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29885990/duck-interferon-regulatory-factor-7-irf7-can-control-duck-tembusu-virus-dtmuv-infection-by-triggering-type-i-interferon-production-and-its-signal-transduction-pathway
#10
Shun Chen, Tao Wang, Peng Liu, Chao Yang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Anchun Cheng
Human interferon regulatory factor 7 (IRF7) plays an important role in the innate antiviral immune response. To date, the characteristics and functions of waterfowl IRF7 have not been clarified. This study reports the cDNA sequence, tissue distribution, and antiviral function of duck IRF7. The duck IRF7 gene has a 1536-bp open read frame (ORF) and encodes a 511-amino acid polypeptide. IRF7 is highly expressed in the blood and pancreas of 5-day-old ducklings and in the small intestine, large intestine and liver of 60-day-old adult ducks...
June 6, 2018: Cytokine
https://www.readbyqxmd.com/read/29885902/inducible-nitric-oxide-synthase-mediated-injury-in-a-mouse-model-of-acute-salivary-gland-dysfunction
#11
Abeer Shaalan, Guy Carpenter, Gordon Proctor
AIM: Inducible nitric oxide synthase (iNOS) is a key regulator of the innate immune system. The aim of the current study was to explore whether innate immune-mediated iNOS and reactive nitrogen species acutely perturb acinar cell physiology and calcium homeostasis of exocrine salivary tissues. METHODS: Innate immunity in the submandibular gland of C57BL/6 mice was locally activated via intraductal retrograde infusion of polyinosinic:polycytidylic acid (poly (I:C)...
June 7, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29882603/galectin-3-binding-protein-a-multitask-glycoprotein-with-innate-immunity-functions-in-viral-and-bacterial-infections
#12
REVIEW
Vuokko Loimaranta, Jussi Hepojoki, Olli Laaksoaho, Arto T Pulliainen
Galectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified and mainly studied in the context of neoplastic transformation and cancer progression. However, Gal-3BP expression is induced in viral infection and by a multitude of molecules that either mimic or are characteristic for an ongoing inflammation and microbial infection, such as IFN-α, IFN-β, IFN-γ, TNF-α, poly(I:C), dsRNA, and dsDNA. Furthermore, Gal-3BP belongs to the scavenger receptor cysteine-rich (SRCR) domain-containing protein family, by virtue of its N-terminal SRCR domain...
June 8, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29879819/molecular-characterization-and-expression-of-adamts8-a-disintegrin-and-metalloproteinase-with-thrombospondin-motifs-8-in-chicken
#13
Ra Ham Lee, Seokhyun Lee, Yu Ra Kim, Hak-Kyo Lee, Ki-Duk Song
Objective: A disintegrin and metallopeptidase with thrombospondin motifs type 8 (ADAMTS8) is crucial for diverse physiological processes, such as inflammation, tissue morphogenesis, and tumorigenesis. The chicken ADAMTS8 (chADAMTS8) gene was differentially expressed in the kidney following exposure to different calcium concentrations, suggesting a pathological role of this protein in metabolic diseases. We aimed to examine the molecular characteristics of chADAMTS8 and analyze the gene-expression differences in response to Toll-like receptor 3 (TLR3) stimulation...
May 31, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29879653/a-top-down-approach-to-actuate-poly-amine-co-ester-terpolymers-for-potent-and-safe-mrna-delivery
#14
Yuhang Jiang, Alice Gaudin, Junwei Zhang, Tushar Agarwal, Eric Song, Amy C Kauffman, Gregory T Tietjen, Yongheng Wang, Zhaozhong Jiang, Christopher J Cheng, W Mark Saltzman
Gene delivery is known to be a complicated multi-step biological process. It has been observed that subtle differences in the structure and properties of polymeric materials used for gene delivery can lead to dramatic differences in transfection efficiency. Therefore, screening of properties is pivotal to optimizing the polymer. So far, most polymeric materials are built in a "bottom-up" manner, i.e. synthesized from monomers that allow modification of polymer composition or structural factors. With this method, we previously synthesized and screened a library of biodegradable poly(amine-co-ester) (PACE) terpolymers for optimized DNA delivery...
May 25, 2018: Biomaterials
https://www.readbyqxmd.com/read/29879501/isolation-and-characterization-of-porcine-pilrb-gene-and-its-alternative-splicing-variants
#15
Xiu-Qin Yang, Xiao-Yan Jing, Cai-Xia Zhang, Yan-Fang Song, Di Liu
Paired immunoglobulin-like type 2 receptor (PILR)β regulates inflammatory responses to pathogen infection, and therefore plays an important role in host disease resistance/susceptibility. However porcine PILRβ remains poorly characterized. In this study, we obtained the cDNA (V1) of its encoding gene, PILRB, and three alternative splicing (AS) variants (V2-4). The complete coding sequence of V1 was 621 bp long encoding a polypeptide of 206 aa. Compared with V1, V2 and V3 were formed by exon-skipping in the 3'-untranslated region (UTR), while V4 was formed by alternative 3' splice site of exon 3, resulting in a premature termination codon, combined with exon skipping in the 3'-UTR...
June 4, 2018: Gene
https://www.readbyqxmd.com/read/29873385/unraveling-the-4n-1-rule-for-dna-i-motif-stability-base-pairs-vs-loop-lengths
#16
Aaron M Fleming, Kayla M Stewart, Gabriela M Eyring, Tyler E Ball, Cynthia J Burrows
Previously our laboratory identified that poly-2'-deoxycytidine (dCn) strands of DNA with lengths greater than 12 nucleotides could adopt i-motif folds, while the pH-dependent stabilities follow a 4n - 1 repeat pattern with respect to chain length (J. Am. Chem. Soc., 2017, 139, 4682-4689). Herein, model i-motif folds in which loop configurations were forced by judiciously mutating dC to non-dC nucleotides allowed a structural model to be proposed to address this phenomenon. The model was developed by systematically studying two i-motifs with either an even or odd number of d(C·C)+ hemiprotonated base pairs in the core...
June 6, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29870743/immunogenicity-of-diphtheria-toxoid-and-poly-i-c-loaded-cationic-liposomes-after-hollow-microneedle-mediated-intradermal-injection-in-mice
#17
Guangsheng Du, Mara Leone, Stefan Romeijn, Gideon Kersten, Wim Jiskoot, Joke A Bouwstra
In this study, we aimed to investigate the immunogenicity of cationic liposomes loaded with diphtheria toxoid (DT) and poly(I:C) after hollow microneedle-mediated intradermal vaccination in mice. The following liposomal formulations were studied: DT loaded liposomes, a mixture of free DT and poly(I:C)-loaded liposomes, a mixture of DT-loaded liposomes and free poly(I:C), and liposomal formulations with DT and poly(I:C) either individually or co-encapsulated in the liposomes. Reference groups were DT solution adjuvanted with or without poly(I:C) (DT/poly(I:C))...
June 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29870012/metal-organic-framework-assembled-from-erbium-and-a-tetrapodal-polyphosphonic-acid-organic-linker
#18
Ricardo F Mendes, Ana D G Firmino, João P C Tomé, Filipe A Almeida Paz
A three-dimensional metal-organic framework (MOF), poly[[μ6 -5'-pentahydrogen [1,1'-biphenyl]-3,3',5,5'-tetrayltetrakis(phosphonato)]erbium(III)] 2.5-hydrate], formulated as [Er(C12 H11 O12 P4 )]·2.5H2 O or [Er(H5 btp)]·2.5H2 O (I) and isotypical with a Y3+ -based MOF reported previously by our research group [Firmino et al. (2017b). Inorg. Chem. 56, 1193-1208], was constructed based solely on Er3+ and on the polyphosphonic organic linker [1,1'-biphenyl]-3,3',5,5'-tetrakis(phosphonic acid) (H8 btp). The present work describes our efforts to introduce lanthanide cations into the flexible network, demonstrating that, on the one hand, the compound can be obtained using three distinct experimental methods, i...
June 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29870009/three-dimensional-organic-inorganic-hybrid-sodium-halide-perovskite-c-4-h-12-n-2-%C3%A2-nai-3-and-a-hydrogen-bonded-supramolecular-three-dimensional-network-in-3c-4-h-12-n-2-%C3%A2-nai-4-%C3%A2-3i%C3%A2-h-2-o
#19
Xiao Gang Chen, Ji Xing Gao, Xiu Ni Hua, Wei Qiang Liao
The rational selection of ligands is vitally important in the construction of new organic-inorganic hybrid three-dimensional perovskite complexes. As part of an exploration of perovskite-type materials, two new Na-I compounds based on the piperazine ligand, namely poly[piperazinediium [tri-μ-iodido-sodium]], {(C4 H12 N2 )[NaI3 ]}n , 1, and catena-poly[tris(piperazinediium) [[triiodidosodium]-μ-iodido] triiodide monohydrate], {(C4 H12 N2 )3 [NaI4 ]I3 ·H2 O}n , 2, have been synthesized by adjusting the stoichiometric ratio of sodium iodide and piperazine, and were characterized by single-crystal X-ray diffraction...
June 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29869526/-i-salmonella-i-mediated-cytolethal-distending-toxin-transfer-inhibits-tumor-growth-i-i
#20
Wei-Kuang Wang, Wei-Cheng Chiang, Chih-Ho Lai, Che-Hsin Lee
<i>Salmonella enterica</i> serovar Choleraesuis (S.C.) has potential for antitumor agent due to its tumor-targeting characteristics. Additionally, S.C. can specifically deliver the therapeutic agents and continuously release them during replication. Previously, we successfully used S.C. as vector to transfer therapeutic gene and oncolytic virus. The results indicated that modified S.C. is suited for incorporating other antitumor agents into a single system.<i>Campylobacter jejuni</i> produced Cytolethal distending toxin (Cdt) B that can induce tumor cell apoptosis...
June 5, 2018: Human Gene Therapy
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