keyword
MENU ▼
Read by QxMD icon Read
search

Poly I:C

keyword
https://www.readbyqxmd.com/read/27923398/comparative-transcriptional-profile-of-the-fish-parasite-cryptocaryon-irritans
#1
Ze-Quan Mo, Yan-Wei Li, Hai-Qing Wang, Jiu-Le Wang, Lu-Yun Ni, Man Yang, Guo-Feng Lao, Xiao-Chun Luo, An-Xing Li, Xue-Ming Dan
BACKGROUND: Cryptocaryon irritans is an obligate ectoparasitic ciliate pathogen of marine fishes. It can infect most marine teleosts and cause heavy economic losses in aquaculture. There is currently no effective method of controlling this disease, and little information is available regarding the genes involved in its development and virulence. We aimed to investigate the distinct features of the three major life-cycle stages of C. irritans in terms of gene transcription level, and identify candidate vaccines/drug targets...
December 7, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27922591/re-assessment-of-net-energy-production-and-greenhouse-gas-emissions-avoidance-after-40-years-of-photovoltaics-development
#2
Atse Louwen, Wilfried G J H M van Sark, André P C Faaij, Ruud E I Schropp
Since the 1970s, installed solar photovoltaic capacity has grown tremendously to 230 gigawatt worldwide in 2015, with a growth rate between 1975 and 2015 of 45%. This rapid growth has led to concerns regarding the energy consumption and greenhouse gas emissions of photovoltaics production. We present a review of 40 years of photovoltaics development, analysing the development of energy demand and greenhouse gas emissions associated with photovoltaics production. Here we show strong downward trends of environmental impact of photovoltaics production, following the experience curve law...
December 6, 2016: Nature Communications
https://www.readbyqxmd.com/read/27918297/a-novel-one-dimensional-double-chain-like-zn-ii-coordination-polymer-poly-bis-1-benzyl-1h-imidazole-%C3%AE%C2%BAn-3-tris-%C3%AE-cyanido-%C3%AE%C2%BA-2-c-n-cyanido-%C3%AE%C2%BAc-disilver-i-zinc-ii
#3
Pattiya Krinchampa, Kittipong Chainok, Siriporn Phengthaisong, Sujittra Youngme, Filip Kielar, Nanthawat Wannarit
One of most interesting systems of coordination polymers constructed from the first-row transition metals is the porous Zn(II) coordination polymer system, but the numbers of such polymers containing N-donor linkers are still limited. The title double-chain-like Zn(II) coordination polymer, [Ag2Zn(CN)4(C10H10N2)2]n, presents a one-dimensional linear coordination polymer structure in which Zn(II) ions are linked by bridging anionic dicyanidoargentate(I) units along the crystallographic b axis and each Zn(II) ion is additionally coordinated by a terminal dicyanidoargentate(I) unit and two terminal 1-benzyl-1H-imidazole (BZI) ligands, giving a five-coordinated Zn(II) ion...
December 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27911568/nf%C3%AE%C2%BAb-mediates-mesenchymal-transition-remodeling-and-pulmonary-fibrosis-in-response-to-chronic-inflammation-by-viral-rna-patterns
#4
Bing Tian, Igor Patrikeev, Lorenzo Ochoa, Gracie Vargas, KarryAnne K Belanger, Julia Litvinov, Istvan Boldogh, Bill T Ameredes, Massoud Motamedi, Allan R Brasier
Airway remodeling is resultant of a complex multi-cellular response associated with a progressive decline of pulmonary function in patients with chronic airway disease. Here, repeated infections with respiratory viruses are linked with airway remodeling through largely unknown mechanisms. Although acute activation of the Toll like receptor (TLR)3 pathway by extracellular poly(I:C) induces innate signaling through the NFkB transcription factor in human small airway epithelial cells (hSAECs), prolonged (repetitive or tonic) poly(I:C) stimulation produces chronic stress fiber formation, mesenchymal transition and activation of a fibrotic program...
December 2, 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/27910914/in-vivo-stepwise-immunomodulation-using-chitosan-nanoparticles-as-a-platform-nanotechnology-for-cancer-immunotherapy
#5
Hee Dong Han, Yeongseon Byeon, Jong-Hwa Jang, Hat Nim Jeon, Ga Hee Kim, Min Gi Kim, Chan-Gi Pack, Tae Heung Kang, In Duk Jung, Yong Taik Lim, Young Joo Lee, Jeong-Won Lee, Byung Cheol Shin, Hyung Jun Ahn, Anil K Sood, Yeong-Min Park
Dentritic cell (DC)-based cancer immunotherapy faces challenges in both efficacy and practicality. However, DC-based vaccination requires multiple injections and elaborates ex vivo manipulation, which substantially limits their use. Therefore, we sought to develop a chitosan nanoparticle (CH-NP)-based platform for the next generation of vaccines to bypass the ex vivo manipulation and induce immune responses via active delivery of polyinosinic-polycytidylic acid sodium salt (poly I:C) to target Toll-like receptor 3 (TLR3) in endosomes...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908594/rucaparib-in-relapsed-platinum-sensitive-high-grade-ovarian-carcinoma-ariel2-part-1-an-international-multicentre-open-label-phase-2-trial
#6
Elizabeth M Swisher, Kevin K Lin, Amit M Oza, Clare L Scott, Heidi Giordano, James Sun, Gottfried E Konecny, Robert L Coleman, Anna V Tinker, David M O'Malley, Rebecca S Kristeleit, Ling Ma, Katherine M Bell-McGuinn, James D Brenton, Janiel M Cragun, Ana Oaknin, Isabelle Ray-Coquard, Maria I Harrell, Elaina Mann, Scott H Kaufmann, Anne Floquet, Alexandra Leary, Thomas C Harding, Sandra Goble, Lara Maloney, Jeff Isaacson, Andrew R Allen, Lindsey Rolfe, Roman Yelensky, Mitch Raponi, Iain A McNeish
BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also represent homologous recombination deficiency. In ARIEL2, we assessed the ability of tumour genomic LOH, quantified with a next-generation sequencing assay, to predict response to rucaparib, an oral PARP inhibitor. METHODS: ARIEL2 is an international, multicentre, two-part, phase 2, open-label study done at 49 hospitals and cancer centres in Australia, Canada, France, Spain, the UK, and the USA...
November 28, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27903451/fatty-acid-synthase-plays-a-positive-role-in-shrimp-immune-responses-against-vibrio-parahaemolyticus-infection
#7
Hongliang Zuo, Jiefeng Gao, Jia Yuan, Hengwei Deng, Linwei Yang, Shaoping Weng, Jianguo He, Xiaopeng Xu
Fatty acid synthase (FAS) is an important enzyme that catalyzes the synthesis of fatty acids. In this study, the role of the FAS gene from pacific white shrimp Litopenaeus vannamei (LvFAS) in immune responses against Vibrio parahaemolyticus infection was studied. The expression of LvFAS could be up-regulated upon infection of V. parahaemolyticus and stimulation of lipopolysaccharide and poly (I:C). The promoter of LvFAS was predicted to harbor a NF-κB binding site and dual-luciferase reporter assays demonstrated that the NF-κB family proteins Relish, sRelish and Dorsal could activate the transcription of LvFAS...
November 27, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27899572/c3-symmetric-opioid-scaffolds-are-ph-responsive-dna-condensation-agents
#8
Natasha McStay, Zara Molphy, Alan Coughlan, Attilio Cafolla, Vickie McKee, Nicholas Gathergood, Andrew Kellett
Herein we report the synthesis of tripodal C3-symmetric opioid scaffolds as high-affinity condensation agents of duplex DNA. Condensation was achieved on both supercoiled and canonical B-DNA structures and identified by agarose electrophoresis, viscosity, turbidity and atomic force microscopy (AFM) measurements. Structurally, the requirement of a tris-opioid scaffold for condensation is demonstrated as both di- (C2-symmetric) and mono-substituted (C1-symmetric) mesitylene-linked opioid derivatives poorly coordinate dsDNA...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27895126/versican-deficiency-significantly-reduces-lung-inflammatory-response-induced-by-polyinosine-polycytidylic-acid-stimulation
#9
Inkyung Kang, Ingrid A Harten, Mary Y Chang, Kathleen R Braun, Alyssa Sheih, Mary P Nivison, Pamela Y Johnson, Gail Workman, Gernot Kaber, Stephen P Evanko, Christina K Chan, Mervyn J Merrilees, Steven F Ziegler, Michael G Kinsella, Charles W Frevert, Thomas N Wight
Viral infection is an exacerbating factor contributing to chronic airway diseases such as asthma via mechanisms which are still unclear. Polyinosine-polycytidylic acid (poly I:C), a toll-like receptor (TLR) 3 agonist used as a mimetic to study viral infection, has been shown to elicit inflammatory responses in lungs and to exacerbate pulmonary allergic reactions in animal models. Previously, we have shown that poly I:C stimulates lung fibroblasts to accumulate an extracellular matrix (ECM), enriched in hyaluronan (HA) and its binding partner versican, which promotes monocyte adhesion...
November 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27894895/molecular-characterization-and-expression-analysis-of-olive-flounder-paralichthys-olivaceus-phospholipase-c-gamma-1-and-gamma-2
#10
Soo Ji Woo, Hyae In Jo, Hyung Ho Lee, Joon Ki Chung
Phospholipase C gamma 1 and gamma 2 (PLCG1 and PLCG2) are influential in modulating Ca(2+) and diacylglycerol, second messengers involved in tyrosine kinase-dependent signaling, including growth factor activation. Here, we used RACE (rapid amplification of cDNA ends) to clone cDNA encoding PLCG1 (PoPLCG1) and PLCG2 (PoPLCG2) in the olive flounder (Paralichthys olivaceus). The respective 1313 and 1249 amino acid sequences share high identity with human PLCG1 and PLCG2, and contain the following domains: pleckstrin homology (PH), EF-hand, catalytic X and Y, Src homology 2 (SH2), Src homology 3 (SH3), and C2...
November 25, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27894672/microrna-145-regulates-the-rlr-signaling-pathway-in-miiuy-croaker-after-poly-i-c-stimulation-via-targeting-mda5
#11
Jingjing Han, Yuena Sun, Weihua Song, Tianjun Xu
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that participate in diverse biological processes via degrading the target mRNAs or repressing translation. In this study, the regulation of miRNA to the RLR (RIG-I-like receptor) signaling pathway by degrading the target mRNAs was researched in miiuy croaker. MDA5, a microRNA-145-5p (miR-145-5p) putative target gene, was predicted by bioinformatics, and the target sites from the 3'untranslated region of MDA5 transcripts were confirmed using luciferase reporter assays...
November 25, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27893851/expression-and-regulation-of-piwil-proteins-and-piwi-interacting-rnas-in-rheumatoid-arthritis
#12
Lenka Pleštilová, Michel Neidhart, Giancarlo Russo, Mojca Frank-Bertoncelj, Caroline Ospelt, Adrian Ciurea, Christoph Kolling, Renate E Gay, Beat A Michel, Jiří Vencovský, Steffen Gay, Astrid Jüngel
OBJECTIVE: The PIWIL (P-element induced wimpy testis like protein) subfamily of argonaute proteins is essential for Piwi-interacting RNA (piRNA) biogenesis and their function to silence transposons during germ-line development. Here we explored their presence and regulation in rheumatoid arthritis (RA). METHODS: The expression of PIWIL genes in RA and osteoarthritis (OA) synovial tissues and synovial fibroblasts (SF) was analysed by Real-time PCR, immunofluorescence and Western blot...
2016: PloS One
https://www.readbyqxmd.com/read/27884591/toll-like-receptor-ligands-induce-cytokine-and-chemokine-production-in-human-inner-ear-endolymphatic-sac-fibroblasts
#13
Takechiyo Yamada, Kazuhiro Ogi, Masafumi Sakashita, Masafumi Kanno, Seita Kubo, Yumi Ito, Yoshimasa Imoto, Takahiro Tokunaga, Masayuki Okamoto, Norihiko Narita, Shigeharu Fujieda
OBJECTIVE: Against recent reports concerning cytokine or chemokine in mouse or rat inner ear cells, it is almost unknown whether human inner ear cells would produce cytokine or chemokine. We have for the first time established the human inner-ear-derived fibroblasts from endolymphatic sac. METHODS: The expression levels of Toll-like receptors (TLRs) in human endolymphatic sac fibroblasts, and the effect on cytokine or chemokine production of the TLR ligands have been examined...
November 21, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27883170/macvia-lr-fighting-chronic-diseases-for-active-and-healthy-ageing-in-languedoc-roussillon-a-success-story-of-the-european-innovation-partnership-on-active-and-healthy-ageing
#14
J Bousquet, R Bourret, T Camuzat, P Augé, J Bringer, M Noguès, O Jonquet, J E de la Coussaye, J Ankri, M Cesari, O Guérin, B Vellas, H Blain, S Arnavielhe, A Avignon, B Combe, G Canovas, C Daien, G Dray, A Dupeyron, C Jeandel, I Laffont, D Laune, C Marion, E Pastor, J Y Pélissier, B Galan, J Reynes, J C Reuzeau, A Bedbrook, S Granier, P A Adnet, M Amouyal, B Alomène, P L Bernard, C Berr, D Caimmi, P G Claret, D J Costa, J P Cristol, P Fesler, D Hève, J Millot-Keurinck, D Morquin, G Ninot, M C Picot, N Raffort, F Roubille, A Sultan, J Touchon, V Attalin, C Azevedo, M Badin, K Bakhti, B Bardy, M P Battesti, X Bobia, C Boegner, S Boichot, H Y Bonnin, S Bouly, C Boubakri, J L Bourrain, G Bourrel, V Bouix, V Bruguière, S Cade, W Camu, V Carre, G Cavalli, G Cayla, R Chiron, P Coignard, F Coroian, P Costa, J Cottalorda, B Coulet, A L Coupet, M C Courrouy-Michel, P Courtet, V Cros, F Cuisinier, M Danko, P Dauenhauer, M Dauzat, M David, J M Davy, D Delignières, P Demoly, J Desplan, P Dujols, G Dupeyron, O Engberink, M Enjalbert, C Fattal, J Fernandes, M Fouletier, P Fraisse, P Gabrion, M Gellerat-Rogier, A Gelis, C Genis, N Giraudeau, A Y Goucham, F Gouzi, F Gressard, J C Gris, B Guillot, D Guiraud, V Handweiler, M Hayot, C Hérisson, C Heroum, D Hoa, S Jacquemin, S Jaber, D Jakovenko, C Jorgensen, P Kouyoudjian, R Lamoureux, L Landreau, M Lapierre, D Larrey, C Laurent, M S Léglise, J M Lemaitre, A Le Quellec, F Leclercq, S Lehmann, B Lognos, Cj M Lussert, A Makinson, K Mandrick, P Mares, P Martin-Gousset, A Matheron, G Mathieu, M Meissonnier, G Mercier, P Messner, C Meunier, M Mondain, R Morales, J Morel, D Mottet, P Nérin, P Nicolas, F Nouvel, D Paccard, G Pandraud, M P Pasdelou, J L Pasquié, K Patte, S Perrey, Y M Pers, F Portejoie, J L E Pujol, X Quantin, I Quéré, S Ramdani, J Ribstein, I Rédini-Martinez, S Richard, K Ritchie, J P Riso, F Rivier, J M Robine, C Rolland, E Royère, D Sablot, J L Savy, L Schifano, P Senesse, R Sicard, Y Stephan, D Strubel, G Tallon, M Tanfin, H Tassery, I Tavares, K Torre, V Tribout, A Uziel, P Van de Perre, F Venail, C Vergne-Richard, G Vergotte, L Vian, F Vialla, F Viart, M Villain, E Viollet, M Ychou, J Mercier
The Région Languedoc Roussillon is the umbrella organisation for an interconnected and integrated project on active and healthy ageing (AHA). It covers the 3 pillars of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA): (A) Prevention and health promotion, (B) Care and cure, (C) and (D) Active and independent living of elderly people. All sub-activities (poly-pharmacy, falls prevention initiative, prevention of frailty, chronic respiratory diseases, chronic diseases with multimorbidities, chronic infectious diseases, active and independent living and disability) have been included in MACVIA-LR which has a strong political commitment and involves all stakeholders (public, private, patients, policy makers) including CARSAT-LR and the Eurobiomed cluster...
2016: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/27883010/measles-virus-induces-persistent-infection-by-autoregulation-of-viral-replication
#15
Tomomitsu Doi, Hyun-Jeong Kwon, Tomoyuki Honda, Hiroki Sato, Misako Yoneda, Chieko Kai
Natural infection with measles virus (MV) establishes lifelong immunity. Persistent infection with MV is likely involved in this phenomenon, as non-replicating protein antigens never induce such long-term immunity. Although MV establishes stable persistent infection in vitro and possibly in vivo, the mechanism by which this occurs is largely unknown. Here, we demonstrate that MV changes the infection mode from lytic to non-lytic and evades the innate immune response to establish persistent infection without viral genome mutation...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27878834/characterization-of-mirnas-involved-in-response-to-poly-i-c-in-porcine-airway-epithelial-cells
#16
L Wang, J K Wang, L X Han, J S Zhuo, X Du, D Liu, X Q Yang
MicroRNAs (miRNA) have been implicated in a variety of pathological conditions including infectious diseases. Knowledge of the miRNAs affected by poly(I:C), a synthetic analog of viral double-stranded RNA, in porcine airway epithelial cells (PAECs) contributes to understanding the mechanisms of swine viral respiratory diseases, which bring enormous economic loss worldwide every year. In this study, we used high throughput sequencing to profile miRNA expression in PAECs treated with poly(I:C) as compared to the untreated control...
November 22, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27876623/identification-of-sea-perch-lateolabrax-japonicus-ribonucleoprotein-ptb-binding-1-involved-in-antiviral-immune-response-against-rgnnv
#17
Peng Jia, Wei Liu, Limin Chen, Yilin Jin, Jing Zhang, Kuntong Jia, Meisheng Yi
RIG-I-like receptors (RLRs) can recognize viral RNA and initiate innate antiviral response. In earlier studies, we demonstrated that RLRs were implicated in the antiviral immunity against RGNNV in the seawater fish sea perch (Lateolabrax japonicus). However, potential regulators of RLRs-mediated signaling pathways involved in RGNNV infection remain unclear. In this study, a novel ribonucleoprotein PTB-binding 1 (Raver1) of sea perch (LjRAVER1) was identified for the first time. The cDNA of LjRAVER1 was 4066 bp in length and encoded a deduced polypeptide of 733 amino acids...
November 20, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27876552/long-term-altered-immune-responses-following-fetal-priming-in-a-non-human-primate-model-of-maternal-immune-activation
#18
Destanie R Rose, Milo Careaga, Judy Van de Water, Kim McAllister, Melissa D Bauman, Paul Ashwood
Infection during pregnancy can lead to activation of the maternal immune system and has been associated with an increased risk of having an offspring later diagnosed with a neurodevelopmental disorders (NDD) such as autism spectrum disorder (ASD) or Schizophrenia (SZ). Most maternal immune activation (MIA) studies to date have been in rodents and usually involve the use of lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid (poly I:C). However, since NDD are based on behavioral changes, a model of MIA in non-human primates could potentially provide data that helps illuminate complex behavioral and immune outputs in human NDD...
November 19, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27872844/fabrication-of-poly-%C3%AE%C2%B5-caprolactone-scaffolds-reinforced-with-cellulose-nanofibers-with-and-without-the-addition-of-hydroxyapatite-nanoparticles
#19
Pedro Morouço, Sara Biscaia, Tânia Viana, Margarida Franco, Cândida Malça, Artur Mateus, Carla Moura, Frederico C Ferreira, Geoffrey Mitchell, Nuno M Alves
Biomaterial properties and controlled architecture of scaffolds are essential features to provide an adequate biological and mechanical support for tissue regeneration, mimicking the ingrowth tissues. In this study, a bioextrusion system was used to produce 3D biodegradable scaffolds with controlled architecture, comprising three types of constructs: (i) poly(ε-caprolactone) (PCL) matrix as reference; (ii) PCL-based matrix reinforced with cellulose nanofibers (CNF); and (iii) PCL-based matrix reinforced with CNF and hydroxyapatite nanoparticles (HANP)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27866611/facile-fabrication-of-eco-friendly-nano-mosquitocides-biophysical-characterization-and-effectiveness-on-neglected-tropical-mosquito-vectors
#20
Marimuthu Govindarajan, S L Hoti, Giovanni Benelli
Mosquito (Diptera: Culicidae) vectors are solely responsible for transmitting important diseases such as malaria, dengue, chikungunya, Japanese encephalitis, lymphatic filariasis and Zika virus. Eco-friendly control tools of Culicidae vectors are a priority. In this study, we proposed a facile fabrication process of poly-disperse and stable silver nanoparticles (Ag NPs) using a cheap leaf extract of Ichnocarpus frutescens (Apocyanaceae). Bio-reduced Ag NPs were characterized by UV-vis spectrophotometry, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
December 2016: Enzyme and Microbial Technology
keyword
keyword
106323
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"