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Bone and Soft tissue pathology

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https://www.readbyqxmd.com/read/28331115/spontaneous-multicentric-soft-tissue-sarcoma-in-a-captive-african-pygmy-hedgehog-atelerix-albiventris-case-report-and-literature-review
#1
Josué Díaz-Delgado, Roy Pool, Sharman Hoppes, Argine Cerezo, Óscar Quesada-Canales, George Stoica
This report describes the clinical, macroscopic, histopathological and immunohistological features of a spontaneous multicentric extraskeletal sarcoma in an adult male African hedgehog (Atelerix albiventris). It also provides a succinct up-to-date review on neoplasia in this species. On autopsy examination, main gross findings included a moderately demarcated cranial mass and a multilobulated, caudal intra-abdominal mass. The cranial mass had perforated the underlying temporal and occipital bones and had extended into the cranial vault and was compressing the surface of the cerebellum and cerebrum...
March 23, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28328009/microenvironmental-factors-that-regulate-mesenchymal-stem-cells-lessons-learned-from-the-study-of-heterotopic-ossification
#2
REVIEW
Chen Kan, Lijun Chen, Yangyang Hu, Haimei Lu, Yuyun Li, John A Kessler, Lixin Kan
Bone marrow contains a non-hematopoietic, clonogenic, multipotent population of stromal cells that are later called mesenchymal stem cells (MSC). Similar cells that share many common features with MSC are also found in other organs, which are thought to contribute both to normal tissue regeneration and to pathological processes such as heterotopic ossification (HO), the formation of ectopic bone in soft tissue. Understanding the microenvironmental factors that regulate MSC in vivo is essential both for understanding the biology of the stem cells and for effective translational applications of MSC...
March 22, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28327074/successful-treatment-of-mandibular-nonunion-with-cortical-allograft-cancellous-autograft-and-locking-titanium-miniplates-in-a-dog
#3
Christopher J Snyder, Jason A Bleedorn, Jason W Soukup
Discontinuities of the mandible can occur for a variety of reasons including primary pathology of bone, pathologic fracture secondary to periodontal disease, and segmental resection for the treatment of neoplasia. Surgical intervention is necessary in many cases to establish normal occlusion and normal mandibular function. Rigid stabilization and treatment of these defects can be challenging due to the limited availability of bone for fixation as well as limited soft tissue coverage. This case report describes successful treatment of a nonunion fracture using cortical allograft and locking titanium miniplates...
September 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28324121/-impingement-syndrome-of-the-ankle
#4
R-I Milos, L B Fritz, C Schueller-Weidekamm
Impingement syndrome of the ankle is a clinical diagnosis caused posttraumatically by overuse due to repetitive mechanical loading or the presence of predisposing anatomical variants. Ankle impingement syndrome is characterized by chronic pain and limited range of movement caused by mechanical compression of bony or soft tissues within the joint compartments. Ankle impingement syndrome is classified according to the various anatomical locations around the tibiotalar joint as anterior, anterolateral, anteromedial, posterior or posteromedial...
March 21, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28315426/vascular-patterning-in-human-heterotopic-ossification
#5
Margaret Cocks, Aditya Mohan, Carolyn A Meyers, Catherine Ding, Benjamin Levi, Edward McCarthy, Aaron W James
Heterotopic ossification (HO, also termed myositis ossificans) is the formation of extra-skeletal bone in muscle and soft tissues. HO is a tissue repair process gone awry, and is a common complication of surgery and traumatic injury. Medical strategies to prevent and treat HO fall well short of addressing the clinical need. Better characterization of the tissues supporting HO is critical to identifying therapies directed against this common and sometimes devastating condition. The physiologic processes of osteogenesis and angiogenesis are highly coupled and interdependent...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28315298/pneumosinus-dilatans-over-100%C3%A2-years-without-an-etiology
#6
Joseph A Ricci
PURPOSE: Pneumosinus dilatans (PD) is a rare pathologic hyperaeration of the paranasal sinuses that causes serious deformation of the overlying bone and soft tissue. The condition occurs most commonly in the frontal sinus of young men who present with different complaints, including cosmetic. More than 100 cases have been reported in the literature since it was first described in 1898; however, the etiology of this condition remains unclear. MATERIALS AND METHODS: A systematic review of all available clinical publications on the subject of PD was conducted in the PubMed electronic database...
February 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28297758/-role-of-master-transcriptional-factor-prox-1-in-lymphatic-endothelial-differentiation-of-kaposiform-hemangioendothelioma
#7
Z Y Ke, S J Yang
Objective: To analyze the clinical and pathological features of Kaposiform hemangioendothelioma (KHE), and to investigate the role of master transcriptional factor Prox-1 in the regulation of lymphatic differentiation. Methods: Nine cases of KHE (during the period from October 2009 to June 2016) were collected with clinical and pathological data. H&E stained section review and immunohistochemietry using the Dako EnVision method were performed. Results: There were 6 female and 3 male patients with age ranging from 2 months to 8 years (median 3 years and 4 months)...
March 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28296944/multiple-osteochondromas-of-the-antlers-and-cranium-in-a-free-ranging-white-tailed-deer-odocoileus-virginianus
#8
Uwe Kierdorf, Karl V Miller, Stefan Flohr, Santiago Gomez, Horst Kierdorf
This paper reports a case of multiple osteochondromas affecting the antlers and the left zygomatic bone of a free-ranging adult white-tailed buck (Odocoileus virginianus) from Georgia, USA. Along with a few postcranial bones, the antlered cranium of the individual was found in a severely weathered condition and devoid of any soft tissue. The antlers exhibited five pedunculated exostoses that were composed of cancellous bone and, in their peripheral portions, also mineralized cartilage. The largest of the exostoses, located on the right antler, had a maximum circumference of 55 cm...
2017: PloS One
https://www.readbyqxmd.com/read/28289512/giant-abdominal-osteosarcoma-causing-intestinal-obstruction-treated-with-resection-and-adjuvant-chemotherapy
#9
Alexandros Diamantis, Grigorios Christodoulidis, Dionysia Vasdeki, Foteini Karasavvidou, Evangelos Margonis, Konstantinos Tepetes
Extraskeletal osteosarcoma (ESOS) is an uncommon tumor that accounts for 1% of all soft tissue sarcomas and 4% of all osteosarcomas. Its presentation may be atypical, while pain has been described as the most common symptom. Radiological findings include a large mass in the soft-tissues with massive calcifications, but no attachment to the adjacent bone or periosteum. We present the case of a 73-year-old gentle man who presented with a palpable, tender abdominal mass and symptoms of bowel obstruction. Computer tomography images revealed a large space-occupying heterogeneous, hyper dense soft tissue mass involving the small intestine...
February 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28286393/versatility-of-fibula-free-flap-in-reconstruction-of-facial-defects-a-center-study
#10
Sunil S Shroff, Sanjiv C Nair, Anjan Shah, Balasubramanya Kumar
PURPOSE: To study a series of cases where vascularised fibula flap was used in various combinations of bone with muscle and skin along with its modifications for reconstruction of simple and composite defects of the facial region. PATIENTS AND METHODS: The investigators designed a retrospective study composed of patients with any pathology or defect who underwent reconstruction of maxilla or mandible with vascularised fibula free flap from 2009 to 2013. All patients were evaluated for age, gender, location and type of defect, incorporation of adjoining skin paddle and muscle, number of fibula osteotomies, ischaemia time, anticoagulant regimen, length of hospital stay, flap failure rate, dental implant rehabilitation...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28280877/unusual-intraosseous-fossilized-soft-tissues-from-the-middle-triassic-nothosaurus-bone
#11
Dawid Surmik, Bruce M Rothschild, Roman Pawlicki
Fossilized soft tissues, occasionally found together with skeletal remains, provide insights to the physiology and functional morphology of extinct organisms. Herein, we present unusual fossilized structures from the cortical region of bone identified in isolated skeletal remains of Middle Triassic nothosaurs from Upper Silesia, Poland. The ribbed or annuli-shaped structures have been found in a sample of partially demineralized coracoid and are interpreted as either giant red blood cells or as blood vessel walls...
April 2017: Die Naturwissenschaften
https://www.readbyqxmd.com/read/28274512/practical-use-and-utility-of-fluorescence-in-situ-hybridization-in-the-pathological-diagnosis-of-soft-tissue-and-bone-tumors
#12
Shintaro Sugita, Tadashi Hasegawa
During routine pathological examination, fluorescence in situ hybridization (FISH) plays a significant role in the genetic analysis of samples. FISH can detect genetic abnormalities such as chromosomal translocations, gene amplifications, and deletions in formalin-fixed, paraffin-embedded (FFPE) specimens. Due to its practical advantages, FISH is already used in many pathology laboratories. It is especially useful for the diagnosis of translocation-related sarcomas (TRSs), which comprise about 25% of soft tissue sarcomas...
March 5, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28272212/ophthalmic-manifestations-in-igg4-related-disease-clinical-presentation-and-response-to-treatment-in-a-french-case-series
#13
Mikael Ebbo, Matthieu Patient, Aurelie Grados, Matthieu Groh, Julien Desblaches, Eric Hachulla, David Saadoun, Sylvain Audia, Aude Rigolet, Benjamin Terrier, Antoinette Perlat, Constance Guillaud, Frederic Renou, Emmanuelle Bernit, Nathalie Costedoat-Chalumeau, Jean-Robert Harlé, Nicolas Schleinitz
IgG4-related disease (IgG4-RD) is characterized by variable tissue or organ involvements sharing common pathological findings. Orbital or orbital adnexa involvement of the disease has been reported in a few case series. The aim of our study was to characterize and analyze ophthalmic manifestations from a nationwide French case-series.Patients with IgG4-RD and orbital or orbital adnexa involvement included in the French multicentric IgG4-RD case-registry were identified. Only patients fulfilling "modified" comprehensive diagnostic criteria with pathological documentation were retained for the study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28271361/prognosis-of-local-recurrence-in-giant-cell-tumour-of-bone-what-can-we-do
#14
REVIEW
Yifeng He, Ji Zhang, Xiaoyi Ding
Giant cell tumour of bone (GCTB) is classified as an intermediate tumour with rare metastasis, but is challenged by local recurrence. This review focuses on the role of radiological evaluation in terms of prognosis of local recurrence in GCTB. We hope to highlight the value of radiological evaluation by integrating studies on the impact of surgical treatments and non-surgical factors on local recurrence of GCTB and the current statuses of genetic and molecular prognostic factors of GCTB. Radiological evaluation can provide diverse information on tumours...
March 7, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28255116/-nrp-1-expression-in-healing-process-of-traumatic-brain-injury-combined-with-tibial-fracture
#15
Zhengzheng Li, Junwei Zhao, Wei Luo, Kang Li, Shuanhu Lei, Yuliang Wang
To examine the expression of neuropilin-1 (Nrp-1), semaphorin 3A (Sema3A) and vascular endothelial growth factor (VEGF) in the healing process of tibial fracture after traumatic brain injury and to explore the mechanism of Nrp-1 in the formation of pathological callus after nerve injury.
 Methods: A total of 192 Wister female rats, 8-10 weeks old and weighing 220-250 g, were randomly divided into a control group (Group C), a tibia fracture group (Group F), a traumatic brain injury group (Group TBI), a traumatic brain injury combined with the tibia fracture group (Group TBI+F) (n=48 in each group)...
February 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28250857/comparative-analysis-of-99m-tc-mdp-three-phase-bone-scan-with-spect-ct-and-99m-tc-hmpao-labeled-wbc-spect-ct-in-the-differential-diagnosis-of-clinically-suspicious-post-traumatic-osteomyelitis
#16
Chanwoo Kim, Soo Jin Lee, Ji Young Kim, Kyu Tae Hwang, Yun Young Choi
PURPOSE: To identify differences between three-phase bone scan and SPECT/CT (TBS) and WBC SPECT/CT (WS) and compare diagnostic accuracies of each modality in patients with suspicious post-traumatic osteomyelitis (OM). METHODS: Twenty-one patients with suspicious post-traumatic OM were enrolled. All patients performed TBS and WS within 1 week. Foci of MDP and WBC accumulation were divided into three categories: bone (OM), soft tissue (soft tissue inflammation; STI), negative for inflammation (NI)...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28246187/tgf-%C3%AE-family-signaling-in-connective-tissue-and-skeletal-diseases
#17
Elena Gallo MacFarlane, Julia Haupt, Harry C Dietz, Eileen M Shore
The transforming growth factor β (TGF-β) family of signaling molecules, which includes TGF-βs, activins, inhibins, and numerous bone morphogenetic proteins (BMPs) and growth and differentiation factors (GDFs), has important functions in all cells and tissues, including soft connective tissues and the skeleton. Specific TGF-β family members play different roles in these tissues, and their activities are often balanced with those of other TGF-β family members and by interactions with other signaling pathways...
February 28, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28229056/experimental-visualization-of-labyrinthine-structure-with-optical-coherence-tomography
#18
Saleh Mohebbi, Marjan Mirsalehi, Lüder-Alexander Kahrs, Tobias Ortmaier, Thomas Lenarz, Omid Majdani
INTRODUCTION: Visualization of inner ear structures is a valuable strategy for researchers and clinicians working on hearing pathologies. Optical coherence tomography (OCT) is a high-resolution imaging technology which may be used for the visualization of tissues. In this experimental study we aimed to evaluate inner ear anatomy in well-prepared human labyrinthine bones. MATERIALS AND METHODS: Three fresh human explanted temporal bones were trimmed, chemically decalcified with ethylenediaminetetraacetic acid (EDTA), and mechanically drilled under visual control using OCT in order to reveal the remaining bone shell...
January 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28225435/the-role-of-18f-fdg-pet-ct-in-staging-and-restaging-primary-bone-lymphoma
#19
Yiyan Liu
PURPOSE: Primary bone lymphoma (PBL) is one of the rarest primary bone malignancies. Very limited data are available on the role of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in PBL. PATIENTS AND METHODS: Overall, 16 relevant patients had F-FDG PET/CT for staging or staging/restaging PBL. The cases with extraskeletal lesions such as lymphadenopathy or with osseous involvements in disseminated lymphoma were excluded on the basis of the definition of PBL. F-FDG PET/CT findings were correlated to pathologic and/or anatomic image information...
April 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28217455/neoplastic-diseases-of-the-spermatic-cord-an-overview-of-pathological-features-evaluation-and-management
#20
REVIEW
Gautam Dagur, Jason Gandhi, Kailash Kapadia, Rafid Inam, Noel L Smith, Gargi Joshi, Sardar Ali Khan
Extracellular tumors found with the spermatic cord, known as neoplasms, are usually identified to be benign. However, the accurate and timely diagnosis of spermatic cord masses is highly crucial, especially when most results are often overlooked or unclear. In this review, we discuss the anatomy and embryology of the spermatic cord. Upon rooting these fundamental concepts, we discuss an array of benign and malignant neoplastic tumors, including their origin, pathological features, clinical evaluation and management, as well as other case-specific characteristics of unique presentation...
February 2017: Translational Andrology and Urology
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