Michel P M Vierboom, Karin Dijkman, Claudia C Sombroek, Sam O Hofman, Charelle Boot, Richard A W Vervenne, Krista G Haanstra, Maarten van der Sande, Liesbeth van Emst, Jorge Domínguez-Andrés, Simone J C F M Moorlag, Clemens H M Kocken, Jelle Thole, Esteban Rodríguez, Eugenia Puentes, Joost H A Martens, Reinout van Crevel, Mihai G Netea, Nacho Aguilo, Carlos Martin, Frank A W Verreck
BCG vaccination can strengthen protection against pathogens through the induction of epigenetic and metabolic reprogramming of innate immune cells, a process called trained immunity. We and others recently demonstrated that mucosal or intravenous BCG better protects rhesus macaques from Mycobacterium tuberculosis infection and TB disease than standard intradermal vaccination, correlating with local adaptive immune signatures. In line with prior mouse data, here, we show in rhesus macaques that intravenous BCG enhances innate cytokine production associated with changes in H3K27 acetylation typical of trained immunity...
January 19, 2021: Cell reports medicine