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https://www.readbyqxmd.com/read/28607760/effects-of-expiratory-muscle-strength-training-on-maximal-respiratory-pressure-and-swallow-related-quality-of-life-in-individuals-with-multiple-sclerosis
#1
Erin Pearson Silverman, Sarah Miller, Yi Zhang, Bari Hoffman-Ruddy, James Yeager, Janis J Daly
BACKGROUND: Weakening and dyscoordination of expiratory muscles in multiple sclerosis (MS) can impair respiratory and swallow function. OBJECTIVE: The objective of this paper is to test a novel expiratory muscle strength training (EMST) device on expiratory pressure, swallow function, and swallow-related quality-of-life (SWAL-QOL) in individuals with MS. METHODS: Participants with MS were randomized to a five-week breathing practice of either positive pressure load (EMST) or near-zero pressure (sham)...
April 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28552790/short-term-expiratory-muscle-strength-training-attenuates-sleep-apnea-and-improves-sleep-quality-in-patients-with-obstructive-sleep-apnea
#2
Yu-Chi Kuo, Ting-Ting Song, Jeffrey R Bernard, Yi-Hung Liao
This study investigated the effects of 5 weeks of expiratory muscle strength training (EMST) on sleep apnea, sleep quality, and respiratory muscle strength in patients with different levels of obstructive sleep apnea (OSA). Twenty-five outpatients who received a diagnosis of OSA participated in the study and were assigned to either the EMST group (n=13) or control group (CTRL, n=12). The training intensity for the EMST group was 75% of the maximum static expiratory (PEmax) score (5days/week). The PEmax, apnea-hypoapnea index (AHI), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI) scores were evaluated before and after the treatment...
May 25, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28527233/effect-of-expiratory-muscle-strength-training-intervention-on-the-maximum-expiratory-pressure-and-quality-of-life-of-patients-with-parkinson-disease
#3
Yu-Chi Kuo, Jomei Chan, Yu-Ping Wu, Jeffrey R Bernard, Yi-Hung Liao
PURPOSE: The purpose of this study was to investigate the effects of 4-weeks expiratory muscle strength training (EMST) on the maximum expiratory pressure (PEmax) and quality of life (QoL) in patients with Parkinson disease (PD). METHODS: Thirteen outpatients diagnosed with PD participated in this study, and were assigned into either a 5DE training group (5DE group; n = 4; 75% PEmax for 5-d/wk), 3DE training group (3DE group; n = 5; 75% PEmax for 3-d/wk) and control group (3DC group; n = 4; 0% PEmax for 3-d/wk) by matching their Hoehn and Yahr scale, genders, and age...
May 13, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28358377/mitochondrial-complex-i-inhibition-triggers-a-mitophagy-dependent-ros-increase-leading-to-necroptosis-and-ferroptosis-in-melanoma-cells
#4
Farhan Basit, Lisanne Mpe van Oppen, Laura Schöckel, Hasse M Bossenbroek, Sjenet E van Emst-de Vries, Johannes Cw Hermeling, Sander Grefte, Charlotte Kopitz, Melanie Heroult, Peter Hgm Willems, Werner Jh Koopman
Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 ('BAY') triggers death of BRAF(V600E) melanoma cell lines and inhibits in vivo tumor growth. Here we studied the mechanism by which this inhibition induces melanoma cell death. BAY treatment depolarized the mitochondrial membrane potential (Δψ), increased cellular ROS levels, stimulated lipid peroxidation and reduced glutathione levels. These effects were paralleled by increased opening of the mitochondrial permeability transition pore (mPTP) and stimulation of autophagosome formation and mitophagy...
March 30, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/27979924/tumor-suppressors-btg1-and-ikzf1-cooperate-during-mouse-leukemia-development-and-increase-relapse-risk-in-b-cell-precursor-acute-lymphoblastic-leukemia-patients
#5
Blanca Scheijen, Judith M Boer, René Marke, Esther Tijchon, Dorette van Ingen Schenau, Esmé Waanders, Liesbeth van Emst, Laurens T van der Meer, Rob Pieters, Gabriele Escherich, Martin A Horstmann, Edwin Sonneveld, Nicola Venn, Rosemary Sutton, Luciano Dalla-Pozza, Roland P Kuiper, Peter M Hoogerbrugge, Monique L den Boer, Frank N van Leeuwen
Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or negate the effects of IKZF1 deletions on prognosis. In a large discovery cohort of 533 childhood B-cell precursor acute lymphoblastic leukemia patients, we observed that single-copy losses of BTG1 were significantly enriched in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia (P=0...
March 2017: Haematologica
https://www.readbyqxmd.com/read/27299944/-dysphagia-in-parkinson-s-disease-pathophysiology-diagnosis%C3%A2-and-therapy
#6
I Suttrup, T Warnecke
Oropharyngeal and esophageal dysphagia are a frequent, but seldom diagnosed symptom of Parkinson's disease (PD). More than 80 % of patients with PD develop dysphagia during the course of their disease leading to a reduced quality of life, complicated medication intake, malnutrition and aspiration pneumonia, which is a major cause of death in PD. The underlying pathophysiology is poorly understood. Impaired dopaminergic and non-dopaminergic mechanisms of the cortical swallowing network as well as peripheral neuromuscular involvement have been suggested to contribute to its multifactorial genesis...
July 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27198586/effect-of-expiratory-muscle-strength-training-on-swallowing-related-muscle-strength-in-community-dwelling-elderly-individuals-a-randomized-controlled-trial
#7
Ji-Su Park, Dong-Hwan Oh, Moon-Young Chang
OBJECTIVE: This study aimed to investigate the effect of expiratory muscle strength training (EMST) on swallowing-related muscle strength in community-dwelling elderly individuals. BACKGROUND: Expiratory muscle strength training is an intervention for patients with oropharyngeal dysphagia. This training is associated with respiration, coughing, speech and swallowing, and its effectiveness has been proven in previous studies. However, the effects of EMST on elderly individuals and evidence are still lacking...
May 16, 2016: Gerodontology
https://www.readbyqxmd.com/read/27130637/rehabilitation-of-swallowing-and-cough-functions-following-stroke-an-expiratory-muscle-strength-training-trial
#8
Karen Wheeler Hegland, Paul W Davenport, Alexandra E Brandimore, Floris F Singletary, Michelle S Troche
OBJECTIVE: To determine the effect of expiratory muscle strength training (EMST) on both cough and swallow function in stroke patients. DESIGN: Prospective pre-post intervention trial with 1 participant group. SETTING: Two outpatient rehabilitation clinics. PARTICIPANTS: Adults (N=14) with a history of ischemic stroke in the preceding 3 to 24 months. INTERVENTION: EMST. The training program was completed at home and consisted of 25 repetitions per day, 5 days per week, for 5 weeks...
August 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27036158/tumor-suppressors-btg1-and-btg2-regulate-early-mouse-b-cell-development
#9
LETTER
Esther Tijchon, Liesbeth van Emst, Laurensia Yuniati, Dorette van Ingen Schenau, Jørn Havinga, Jean-Pierre Rouault, Peter M Hoogerbrugge, Frank N van Leeuwen, Blanca Scheijen
No abstract text is available yet for this article.
July 2016: Haematologica
https://www.readbyqxmd.com/read/26803525/effects-of-expiratory-muscle-strength-training-on-oropharyngeal-dysphagia-in-subacute-stroke-patients-a-randomised-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
J S Park, D H Oh, M Y Chang, K M Kim
Expiratory muscle strength training (EMST) involves forcible blowing as a means of generating high expiratory pressure, against adjustable resistance. EMST has recently been introduced as a potential treatment for dysphagia. This study was performed to investigate the effects of EMST on the activity of suprahyoid muscles, aspiration and dietary stages in stroke patients with dysphagia. Twenty-seven stroke patients with dysphagia were randomly divided into two groups. The experimental group performed EMST with a 70% threshold value of maximal expiratory pressure, using an EMST device, 5 days a week for 4 weeks...
May 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/26657730/tumor-suppressor-btg1-promotes-prmt1-mediated-atf4-function-in-response-to-cellular-stress
#11
Laurensia Yuniati, Laurens T van der Meer, Esther Tijchon, Dorette van Ingen Schenau, Liesbeth van Emst, Marloes Levers, Sander A L Palit, Caroline Rodenbach, Geert Poelmans, Peter M Hoogerbrugge, Jixiu Shan, Michael S Kilberg, Blanca Scheijen, Frank N van Leeuwen
Cancer cells are frequently exposed to physiological stress conditions such as hypoxia and nutrient limitation. Escape from stress-induced apoptosis is one of the mechanisms used by malignant cells to survive unfavorable conditions. B-cell Translocation Gene 1 (BTG1) is a tumor suppressor that is frequently deleted in acute lymphoblastic leukemia and recurrently mutated in diffuse large B cell lymphoma. Moreover, low BTG1 expression levels have been linked to poor outcome in several solid tumors. How loss of BTG1 function contributes to tumor progression is not well understood...
January 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/26599236/impact-of-expiratory-strength-training-in-amyotrophic-lateral-sclerosis
#12
Emily K Plowman, Stephanie A Watts, Lauren Tabor, Raele Robison, Joy Gaziano, Amanda S Domer, Joel Richter, Tuan Vu, Clifton Gooch
INTRODUCTION: We evaluated the feasibility and impact of expiratory muscle strength training (EMST) on respiratory and bulbar function in persons with amyotrophic lateral sclerosis (ALS). METHODS: Twenty-five ALS patients participated in this delayed intervention open-label clinical trial. Following a lead-in period, patients completed a 5-week EMST protocol. Outcome measures included: maximum expiratory pressure (MEP); physiologic measures of swallow and cough; and penetration-aspiration scale (PAS) scores...
June 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/25620325/quantifying-small-molecule-phenotypic-effects-using-mitochondrial-morpho-functional-fingerprinting-and-machine-learning
#13
Lionel Blanchet, Jan A M Smeitink, Sjenet E van Emst-de Vries, Caroline Vogels, Mina Pellegrini, An I Jonckheere, Richard J T Rodenburg, Lutgarde M C Buydens, Julien Beyrath, Peter H G M Willems, Werner J H Koopman
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberrations constitute linked therapeutic targets for small chemical molecules. However, the latter generally induce multiple subtle effects, meaning that in vitro potency analysis or single-parameter high-throughput cell screening are of limited use to identify these molecules...
2015: Scientific Reports
https://www.readbyqxmd.com/read/25144167/functional-outcomes-associated-with-expiratory-muscle-strength-training-narrative-review
#14
REVIEW
Helena Laciuga, John C Rosenbek, Paul W Davenport, Christine M Sapienza
This review presents the available evidence for the effects of expiratory muscle strength training (EMST) with the use of a pressure threshold device. The investigators used computerized database searches for studies reporting the outcomes of pressure threshold EMST published after 1994. A total of 24 selected articles presented outcomes related but not limited to respiratory function, such as speech, swallow, voice, and cough function in persons with neurologic conditions such as Parkinson disease, multiple sclerosis, and Lance-Adams syndrome; in persons with respiratory diseases, such as chronic obstructive pulmonary disease; and in healthy young adults and sedentary and active elderly...
2014: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/24933728/detraining-outcomes-with-expiratory-muscle-strength-training-in-parkinson-disease
#15
RANDOMIZED CONTROLLED TRIAL
Michelle S Troche, John C Rosenbek, Michael S Okun, Christine M Sapienza
Expiratory muscle strength training (EMST) is efficacious for improving maximum expiratory pressure (MEP), cough function, and swallowing safety in Parkinson disease (PD). However, there are no published reports describing detraining effects following EMST in persons with PD. Moreover, there are no published reports describing detraining effects following any behavioral swallowing intervention. Ten participants with PD underwent 3 mo of detraining following EMST. Measures of MEP and swallowing safety were made prior to beginning EMST (baseline), posttreatment (predetraining), and 3 mo postdetraining...
2014: Journal of Rehabilitation Research and Development
https://www.readbyqxmd.com/read/24808877/here-there-and-everywhere-emotion-and-mental-state-talk-in-different-social-contexts-predicts-empathic-helping-in-toddlers
#16
Jesse Drummond, Elena F Paul, Whitney E Waugh, Stuart I Hammond, Celia A Brownell
A growing body of literature suggests that parents socialize early-emerging prosocial behavior across varied contexts and in subtle yet powerful ways. We focus on discourse about emotions and mental states as one potential socialization mechanism given its conceptual relevance to prosocial behavior and its known positive relations with emotion understanding and social-cognitive development, as well as parents' frequent use of such discourse beginning in infancy. Specifically, we ask how parents' emotion and mental state talk (EMST) with their toddlers relates to toddlers' helping and how these associations vary by context...
2014: Frontiers in Psychology
https://www.readbyqxmd.com/read/24794097/treatment-effects-for-dysphagia-in-parkinson-s-disease-a-systematic-review
#17
REVIEW
M R A van Hooren, L W J Baijens, S Voskuilen, M Oosterloo, B Kremer
BACKGROUND: Dysphagia remains a common problem in Parkinson's disease (PD). Previous systematic reviews on therapy effects for oropharyngeal dysphagia in PD have shown a lack of evidence. In the past 5 years several placebo or sham-controlled trials with varying results have been published. OBJECTIVE: The aim of this systematic literature review is to summarize and qualitatively analyze the published studies on this matter. METHOD(S): Studies published up to December 2013 were found via a systematic comprehensive electronic database search using PubMed, Embase, and The Cochrane Library...
August 2014: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/24601158/fostering-diffusion-of-scientific-contents-of-national-society-cardiovascular-journals-the-new-esc-search-engine
#18
EDITORIAL
Fernando Alfonso, Lino Gonçalves, Fausto Pinto, Adam Timmis, Hugo Ector, Giuseppe Ambrosio, Panos Vardas, Oloizos Antoinades, Eduard Apetrei, Michael Aschermann, Leonardo Bologneze, Mirza Dilic, Istvan Edes, Krzysztof J Filipiak, Faig Guliyev, Habib Haouala, Mahmoud Mohamed Hassanein, Magda Heras, Christer Hoglund, Ivan Hulin, Kurt Huber, Mario Ivanusa, Germanas Marinskis, Izet Masic, Miodrag Ostojic, Otmar Pachinger, Dimitar Raev, Mamanti Rogava, Olaf Rodevand, Vedat Sansoy, Evgeny Shlyakhto, Valentin A Shumakov, Emst Van der Wall, Jorgen Videbaek, Thomas F Luscher
No abstract text is available yet for this article.
2013: Medical Archives
https://www.readbyqxmd.com/read/23954483/maxillofacial-trauma-in-the-emergency-department-a-review
#19
REVIEW
J W Tuckett, A Lynham, G A Lee, M Perry, U Harrington
OBJECTIVES: In 1978 the Advanced Trauma Life Support guidelines were first implemented and are viewed by many as the gold standard of care in the emergency setting. It may not be immediately obvious where assessment and management of maxillofacial injuries fits within these trauma guidelines. This article aims to provide a concise, contemporary guide for the treatment of maxillofacial trauma in the emergency setting. METHODS: An electronic database search was conducted in PubMed and Science Direct on articles from 1970 to the present day...
April 2014: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/23924349/online-formative-tests-linked-to-microlectures-improving-academic-achievement
#20
Rianne A M Bouwmeester, Renske A M de Kleijn, Astrid W M Freriksen, Maarten G van Emst, Rob J Veeneklaas, Maggy J W van Hoeij, Matty Spinder, Magda J Ritzen, Olle Th J Ten Cate, Harold V M van Rijen
BACKGROUND: Online formative tests (OFTs) are powerful tools to direct student learning behavior, especially when enriched with specific feedback. AIM: In the present study, we have investigated the effect of OFTs enriched with hyperlinks to microlectures on examination scores. METHODS: OFTs, available one week preceding each midterm and the final exams, could be used voluntarily. The use of OFTs was related to scores on midterm and final exams using ANOVA, with prior academic achievement as a covariate...
December 2013: Medical Teacher
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