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Blanca Scheijen, Judith M Boer, Rene' Marke, Esther Tijchon, Dorette van Ingen Schenau, Esme' Waanders, Liesbeth van Emst, Laurens T van der Meer, Rob Pieters, Gabriele Escherich, Martin A Horstmann, Edwin Sonneveld, Nicola Venn, Rosemary Sutton, Luciano Dalla-Pozza, Roland P Kuiper, Peter M Hoogerbrugge, Monique L den Boer, Frank N van Leeuwen
Deletions and mutations affecting lymphoid transcription factor IKZF1 (IKAROS) are associated with an increased relapse risk and poor outcome in B-cell precursor acute lymphoblastic leukemia. However, additional genetic events may either enhance or negate the effects of IKZF1 deletions on prognosis. In a large discovery cohort of 533 childhood B-cell precursor acute lymphoblastic leukemia patients, we observed that single copy losses of BTG1 were significantly enriched in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia (P=0...
December 15, 2016: Haematologica
I Suttrup, T Warnecke
Oropharyngeal and esophageal dysphagia are a frequent, but seldom diagnosed symptom of Parkinson's disease (PD). More than 80 % of patients with PD develop dysphagia during the course of their disease leading to a reduced quality of life, complicated medication intake, malnutrition and aspiration pneumonia, which is a major cause of death in PD. The underlying pathophysiology is poorly understood. Impaired dopaminergic and non-dopaminergic mechanisms of the cortical swallowing network as well as peripheral neuromuscular involvement have been suggested to contribute to its multifactorial genesis...
July 2016: Fortschritte der Neurologie-Psychiatrie
Ji-Su Park, Dong-Hwan Oh, Moon-Young Chang
OBJECTIVE: This study aimed to investigate the effect of expiratory muscle strength training (EMST) on swallowing-related muscle strength in community-dwelling elderly individuals. BACKGROUND: Expiratory muscle strength training is an intervention for patients with oropharyngeal dysphagia. This training is associated with respiration, coughing, speech and swallowing, and its effectiveness has been proven in previous studies. However, the effects of EMST on elderly individuals and evidence are still lacking...
May 16, 2016: Gerodontology
Karen Wheeler Hegland, Paul W Davenport, Alexandra E Brandimore, Floris F Singletary, Michelle S Troche
OBJECTIVE: To determine the effect of expiratory muscle strength training (EMST) on both cough and swallow function in stroke patients. DESIGN: Prospective pre-post intervention trial with 1 participant group. SETTING: Two outpatient rehabilitation clinics. PARTICIPANTS: Adults (N=14) with a history of ischemic stroke in the preceding 3 to 24 months. INTERVENTION: EMST. The training program was completed at home and consisted of 25 repetitions per day, 5 days per week, for 5 weeks...
August 2016: Archives of Physical Medicine and Rehabilitation
Esther Tijchon, Liesbeth van Emst, Laurensia Yuniati, Dorette van Ingen Schenau, Jørn Havinga, Jean-Pierre Rouault, Peter M Hoogerbrugge, Frank N van Leeuwen, Blanca Scheijen
No abstract text is available yet for this article.
July 2016: Haematologica
J S Park, D H Oh, M Y Chang, K M Kim
Expiratory muscle strength training (EMST) involves forcible blowing as a means of generating high expiratory pressure, against adjustable resistance. EMST has recently been introduced as a potential treatment for dysphagia. This study was performed to investigate the effects of EMST on the activity of suprahyoid muscles, aspiration and dietary stages in stroke patients with dysphagia. Twenty-seven stroke patients with dysphagia were randomly divided into two groups. The experimental group performed EMST with a 70% threshold value of maximal expiratory pressure, using an EMST device, 5 days a week for 4 weeks...
May 2016: Journal of Oral Rehabilitation
Laurensia Yuniati, Laurens T van der Meer, Esther Tijchon, Dorette van Ingen Schenau, Liesbeth van Emst, Marloes Levers, Sander A L Palit, Caroline Rodenbach, Geert Poelmans, Peter M Hoogerbrugge, Jixiu Shan, Michael S Kilberg, Blanca Scheijen, Frank N van Leeuwen
Cancer cells are frequently exposed to physiological stress conditions such as hypoxia and nutrient limitation. Escape from stress-induced apoptosis is one of the mechanisms used by malignant cells to survive unfavorable conditions. B-cell Translocation Gene 1 (BTG1) is a tumor suppressor that is frequently deleted in acute lymphoblastic leukemia and recurrently mutated in diffuse large B cell lymphoma. Moreover, low BTG1 expression levels have been linked to poor outcome in several solid tumors. How loss of BTG1 function contributes to tumor progression is not well understood...
January 19, 2016: Oncotarget
Emily K Plowman, Stephanie A Watts, Lauren Tabor, Raele Robison, Joy Gaziano, Amanda S Domer, Joel Richter, Tuan Vu, Clifton Gooch
INTRODUCTION: We evaluated the feasibility and impact of expiratory muscle strength training (EMST) on respiratory and bulbar function in persons with amyotrophic lateral sclerosis (ALS). METHODS: Twenty-five ALS patients participated in this delayed intervention open-label clinical trial. Following a lead-in period, patients completed a 5-week EMST protocol. Outcome measures included: maximum expiratory pressure (MEP); physiologic measures of swallow and cough; and penetration-aspiration scale (PAS) scores...
June 2016: Muscle & Nerve
Lionel Blanchet, Jan A M Smeitink, Sjenet E van Emst-de Vries, Caroline Vogels, Mina Pellegrini, An I Jonckheere, Richard J T Rodenburg, Lutgarde M C Buydens, Julien Beyrath, Peter H G M Willems, Werner J H Koopman
In primary fibroblasts from Leigh Syndrome (LS) patients, isolated mitochondrial complex I deficiency is associated with increased reactive oxygen species levels and mitochondrial morpho-functional changes. Empirical evidence suggests these aberrations constitute linked therapeutic targets for small chemical molecules. However, the latter generally induce multiple subtle effects, meaning that in vitro potency analysis or single-parameter high-throughput cell screening are of limited use to identify these molecules...
2015: Scientific Reports
Helena Laciuga, John C Rosenbek, Paul W Davenport, Christine M Sapienza
This review presents the available evidence for the effects of expiratory muscle strength training (EMST) with the use of a pressure threshold device. The investigators used computerized database searches for studies reporting the outcomes of pressure threshold EMST published after 1994. A total of 24 selected articles presented outcomes related but not limited to respiratory function, such as speech, swallow, voice, and cough function in persons with neurologic conditions such as Parkinson disease, multiple sclerosis, and Lance-Adams syndrome; in persons with respiratory diseases, such as chronic obstructive pulmonary disease; and in healthy young adults and sedentary and active elderly...
2014: Journal of Rehabilitation Research and Development
Michelle S Troche, John C Rosenbek, Michael S Okun, Christine M Sapienza
Expiratory muscle strength training (EMST) is efficacious for improving maximum expiratory pressure (MEP), cough function, and swallowing safety in Parkinson disease (PD). However, there are no published reports describing detraining effects following EMST in persons with PD. Moreover, there are no published reports describing detraining effects following any behavioral swallowing intervention. Ten participants with PD underwent 3 mo of detraining following EMST. Measures of MEP and swallowing safety were made prior to beginning EMST (baseline), posttreatment (predetraining), and 3 mo postdetraining...
2014: Journal of Rehabilitation Research and Development
Jesse Drummond, Elena F Paul, Whitney E Waugh, Stuart I Hammond, Celia A Brownell
A growing body of literature suggests that parents socialize early-emerging prosocial behavior across varied contexts and in subtle yet powerful ways. We focus on discourse about emotions and mental states as one potential socialization mechanism given its conceptual relevance to prosocial behavior and its known positive relations with emotion understanding and social-cognitive development, as well as parents' frequent use of such discourse beginning in infancy. Specifically, we ask how parents' emotion and mental state talk (EMST) with their toddlers relates to toddlers' helping and how these associations vary by context...
2014: Frontiers in Psychology
M R A van Hooren, L W J Baijens, S Voskuilen, M Oosterloo, B Kremer
BACKGROUND: Dysphagia remains a common problem in Parkinson's disease (PD). Previous systematic reviews on therapy effects for oropharyngeal dysphagia in PD have shown a lack of evidence. In the past 5 years several placebo or sham-controlled trials with varying results have been published. OBJECTIVE: The aim of this systematic literature review is to summarize and qualitatively analyze the published studies on this matter. METHOD(S): Studies published up to December 2013 were found via a systematic comprehensive electronic database search using PubMed, Embase, and The Cochrane Library...
August 2014: Parkinsonism & related Disorders
Fernando Alfonso, Lino Gonçalves, Fausto Pinto, Adam Timmis, Hugo Ector, Giuseppe Ambrosio, Panos Vardas, Oloizos Antoinades, Eduard Apetrei, Michael Aschermann, Leonardo Bologneze, Mirza Dilic, Istvan Edes, Krzysztof J Filipiak, Faig Guliyev, Habib Haouala, Mahmoud Mohamed Hassanein, Magda Heras, Christer Hoglund, Ivan Hulin, Kurt Huber, Mario Ivanusa, Germanas Marinskis, Izet Masic, Miodrag Ostojic, Otmar Pachinger, Dimitar Raev, Mamanti Rogava, Olaf Rodevand, Vedat Sansoy, Evgeny Shlyakhto, Valentin A Shumakov, Emst Van der Wall, Jorgen Videbaek, Thomas F Luscher
No abstract text is available yet for this article.
2013: Medical Archives
J W Tuckett, A Lynham, G A Lee, M Perry, U Harrington
OBJECTIVES: In 1978 the Advanced Trauma Life Support guidelines were first implemented and are viewed by many as the gold standard of care in the emergency setting. It may not be immediately obvious where assessment and management of maxillofacial injuries fits within these trauma guidelines. This article aims to provide a concise, contemporary guide for the treatment of maxillofacial trauma in the emergency setting. METHODS: An electronic database search was conducted in PubMed and Science Direct on articles from 1970 to the present day...
April 2014: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Rianne A M Bouwmeester, Renske A M de Kleijn, Astrid W M Freriksen, Maarten G van Emst, Rob J Veeneklaas, Maggy J W van Hoeij, Matty Spinder, Magda J Ritzen, Olle Th J Ten Cate, Harold V M van Rijen
BACKGROUND: Online formative tests (OFTs) are powerful tools to direct student learning behavior, especially when enriched with specific feedback. AIM: In the present study, we have investigated the effect of OFTs enriched with hyperlinks to microlectures on examination scores. METHODS: OFTs, available one week preceding each midterm and the final exams, could be used voluntarily. The use of OFTs was related to scores on midterm and final exams using ANOVA, with prior academic achievement as a covariate...
December 2013: Medical Teacher
Miqing Li, Shengxiang Yang, Jinhua Zheng, Xiaohui Liu
The Euclidean minimum spanning tree (EMST), widely used in a variety of domains, is a minimum spanning tree of a set of points in space where the edge weight between each pair of points is their Euclidean distance. Since the generation of an EMST is entirely determined by the Euclidean distance between solutions (points), the properties of EMSTs have a close relation with the distribution and position information of solutions. This paper explores the properties of EMSTs and proposes an EMST-based evolutionary algorithm (ETEA) to solve multi-objective optimization problems (MOPs)...
2014: Evolutionary Computation
Supraja Anand, Nour El-Bashiti, Christine Sapienza
PURPOSE: To determine the effects of expiratory muscle strength training (EMST) frequency on maximum expiratory pressure (MEP). METHOD: We assigned 12 healthy participants to 2 groups of training frequency (3 days per week and 5 days per week). They completed a 4-week training program on an EMST trainer (Aspire Products, LLC). MEP was the primary outcome measure used to determine the effect of training frequency. RESULTS: Participants who trained 3 days per week produced equivalent amounts of improvement in MEP compared with participants who trained 5 days per week...
November 2012: American Journal of Speech-language Pathology
Felix Distelmaier, Federica Valsecchi, Marleen Forkink, Sjenet van Emst-de Vries, Herman G Swarts, Richard J T Rodenburg, Eugène T P Verwiel, Jan A M Smeitink, Peter H G M Willems, Werner J H Koopman
AIMS: Cell regulation by signaling reactive oxygen species (sROS) is often incorrectly studied through extracellular oxidant addition. Here, we used the membrane-permeable antioxidant Trolox to examine the role of sROS in mitochondrial morphology, oxidative phosphorylation (OXPHOS), and cytosolic calcium (Ca(2+)) handling in healthy human skin fibroblasts. RESULTS AND INNOVATION: Trolox treatment reduced the levels of 5-(and-6)-chloromethyl-2',7'-dichlorodihydro-fluorescein (CM-H(2)DCF) oxidizing ROS, lowered cellular lipid peroxidation, and induced a less oxidized mitochondrial thiol redox state...
December 15, 2012: Antioxidants & Redox Signaling
Federica Valsecchi, Claire Monge, Marleen Forkink, Ad J C de Groof, Giovanni Benard, Rodrigue Rossignol, Herman G Swarts, Sjenet E van Emst-de Vries, Richard J Rodenburg, Maria A Calvaruso, Leo G J Nijtmans, Bavo Heeman, Peggy Roestenberg, Be Wieringa, Jan A M Smeitink, Werner J H Koopman, Peter H G M Willems
Human mitochondrial complex I (CI) deficiency is associated with progressive neurological disorders. To better understand the CI pathomechanism, we here studied how deletion of the CI gene NDUFS4 affects cell metabolism. To this end we compared immortalized mouse embryonic fibroblasts (MEFs) derived from wildtype (wt) and whole-body NDUFS4 knockout (KO) mice. Mitochondria from KO cells lacked the NDUFS4 protein and mitoplasts displayed virtually no CI activity, moderately reduced CII, CIII and CIV activities and normal citrate synthase and CV (F(o)F(1)-ATPase) activity...
October 2012: Biochimica et Biophysica Acta
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