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tomography of breast câncer

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https://www.readbyqxmd.com/read/27904868/predictive-ability-of-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-pathological-complete-response-and-prognosis-after-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer-patients
#1
Sachiko Kiyoto, Yoshifumi Sugawara, Kohei Hosokawa, Rieko Nishimura, Natsumi Yamashita, Shozo Ohsumi, Teruhito Mochizuki
OBJECTIVES: The mortality of patients with locally advanced triple-negative breast cancer (TNBC) is high, and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is associated with improved prognosis. This retrospective study was designed and powered to investigate the ability of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) to predict pathological response to NAC and prognosis after NAC. METHODS: The data of 32 consecutive women with clinical stage II or III TNBC from January 2006 to December 2013 in our institution who underwent FDG-PET/CT at baseline and after NAC were retrospectively analyzed...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27900757/unsuspected-axillary-lymph-node-metastasis-of-nasopharyngeal-and-cervical-cancer-on-18fdg-pet-ct-a-case-report
#2
Sungmin Kang
Axillary lymph node metastasis (ALNM) from cancer except breast cancer is rare. Whole body 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) that simultaneously offers anatomic and metabolic information is widely used and has become an effective modality in many clinical fields, especially oncology, and also may detect an unexpected metastasis. We report two cases of ALMN of nasopharyngeal and cervical cancer that was detected on whole body PET/CT.
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27895871/desmoid-tumor-of-the-chest-wall-mimicking-recurrent-breast-cancer-multimodality-imaging-findings
#3
Kyeong A Choi, Yeong Yi An
Desmoid tumor of breast is a rare benign, locally aggressive tumor with a high recurrence rate. It has been associated with scar from previous breast surgery or trauma. Especially in breast cancer patients with previous operation history, it may simulate recurrent breast cancer clinically and radiologically. We presented multimodality imaging findings (ultrasound, computed tomography, magnetic resonance imaging and positron emission tomography/computed tomography) of chest wall desmoid tumor mimicking recurrent breast cancer in a 38-year-old patient with a history of left modified mastectomy...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27895745/evaluation-of-the-association-between-hif-1%C3%AE-and-her-2-expression-hormone-receptor-status-ki-67-expression-histology-and-tumor-fdg-uptake-in-breast-cancer
#4
Sevi M Sureyya Cerci, Kemal Kursat Bozkurt, Hasan Erol Eroglu, Celal Cerci, Evrim Erdemoglu, Pinar Talip Bulbul, Meltem Cetin, Recep Cetin, Ibrahim Metin Ciris, Mahmut Bulbul
The present study aimed to examine hypoxia-inducible factor (HIF)-1α expression and its association with glucose uptake in invasive breast cancer. In addition, connections between glucose uptake and several other prognostic parameters of breast cancer were studied. Between August 2013 and April 2015, 92 patients with biopsy-diagnosed breast cancer were subjected to (18)F-fluorodeoxyglucose positron emission tomography/computed tomography. The primary tumor and nodal maximum standardized uptake values (SUVmax) were recorded, and HIF-1α expression and clinical parameters, including tumor mass, estrogen receptor (ER) and progesterone receptor (PgR) levels, human epidermal growth factor receptor-2 (HER-2), Ki-67 index, grade and histology, were analyzed...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27894335/everolimus-and-exemestane-in-long-survival-hormone-receptor-positive-male-breast-cancer-case-report
#5
Z Ballatore, M Pistelli, N Battelli, A Pagliacci, M De Lisa, R Berardi, S Cascinu
BACKGROUND: Male breast cancer is a rare event, accounting for approximately 1% of all breast carcinomas. Although men with breast cancer had poorer survival when compared with women, data on prognosis principally derive from retrospective studies and from extrapolation of female breast cancer series. We reported the case of a very long survival patient. CASE PRESENTATION: A caucasian 42-year-old man underwent radical mastectomy with axillary dissection for breast cancer in 1993...
November 28, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27890346/the-uk-heartspare-study-stage-ii-multicentre-evaluation-of-a-voluntary-breath-hold-technique-in-patients-receiving-breast-radiotherapy
#6
F R Bartlett, E M Donovan, H A McNair, L A Corsini, R M Colgan, P M Evans, L Maynard, C Griffin, J S Haviland, J R Yarnold, A M Kirby
AIMS: To evaluate the feasibility and heart-sparing ability of the voluntary breath-hold (VBH) technique in a multicentre setting. MATERIALS AND METHODS: Patients were recruited from 10 UK centres. Following surgery for early left breast cancer, patients with any heart inside the 50% isodose from a standard free-breathing tangential field treatment plan underwent a second planning computed tomography (CT) scan using the VBH technique. A separate treatment plan was prepared on the VBH CT scan and used for treatment...
November 24, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27888545/anti-angiogenic-therapy-affects-the-relationship-between-tumor-vascular-structure-and-function-a-correlation-study-between-micro-computed-tomography-angiography-and-dynamic-contrast-enhanced-mri
#7
Eugene Kim, Jana Kim, Gunhild Mari Maelandsmo, Berit Johansen, Siver Andreas Moestue
PURPOSE: To compare the effects of two anti-angiogenic drugs, bevacizumab and a cytosolic phospholipase A2-α inhibitor (AVX235), on the relationship between vascular structure and dynamic contrast enhanced (DCE)-MRI measurements in a patient-derived breast cancer xenograft model. METHODS: Mice bearing MAS98.12 tumors were randomized into three groups: bevacizumab-treated (n = 9), AVX235-treated (n = 9), and control (n = 8). DCE-MRI was performed pre- and post-treatment...
November 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27880851/diagnostic-utility-of-pleural-fluid-cell-block-versus-pleural-biopsy-collected-by-flex-rigid-pleuroscopy-for-malignant-pleural-disease-a-single-center-retrospective-analysis
#8
Shion Miyoshi, Shinji Sasada, Takehiro Izumo, Yuji Matsumoto, Takaaki Tsuchida
BACKGROUND: Some trials recently demonstrated the benefit of targeted treatment for malignant disease; therefore, adequate tissues are needed to detect the targeted gene. Pleural biopsy using flex-rigid pleuroscopy and pleural effusion cell block analysis are both useful for diagnosis of malignancy and obtaining adequate samples. The purpose of our study was to compare the diagnostic utility between the two methods among patients with malignant pleural disease with effusion. METHODS: Data from patients who underwent flex-rigid pleuroscopy for diagnosis of pleural effusion suspicious for malignancy at the National Cancer Center Hospital, Japan between April 2011 and June 2014 were retrospectively reviewed...
2016: PloS One
https://www.readbyqxmd.com/read/27867711/automated-data-selection-method-to-improve-robustness-of-diffuse-optical-tomography-for-breast-cancer-imaging
#9
Hamed Vavadi, Quing Zhu
Imaging-guided near infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response of breast cancers. However, diffused light measurements are sensitive to artifacts caused by outliers and errors in measurements due to probe-tissue coupling, patient and probe motions, and tissue heterogeneity. In general, pre-processing of the measurements is needed by experienced users to manually remove these outliers and therefore reduce imaging artifacts...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27858365/tumor-blood-vessel-visualization
#10
Clarissa Gillmann, Tobias Bäuerle
Noninvasive multimodal imaging of tumor blood vessels allows the qualitative and quantitative assessment of morphological, functional, and molecular features of tumor angiogenesis longitudinally in a living organism. In this chapter we focus on the application of magnetic resonance imaging (MRI), computed tomography (CT), ultrasound (US), and positron emission tomography (PET) in tumor blood vessel visualization on the example of breast cancer bone metastasis in a nude rat model. Thereby, materials and methods are described that are needed to obtain complementary data on tumor vascularization from these imaging techniques...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27843426/successful-endoscopic-submucosal-dissection-of-a-large-terminal-ileal-lipoma
#11
Hisatsugu Noda, Naotaka Ogasawara, Yasuhiro Tamura, Yoshihiro Kondo, Shinya Izawa, Masahide Ebi, Yasushi Funaki, Makoto Sasaki, Kunio Kasugai
A 78-year-old woman who had recurrent right lower abdominal pain for about 1 year underwent computed tomography (CT) because of a follow-up observation 1 year after right breast cancer surgery. CT revealed a tumor in the colon. The patient was referred to our hospital for detailed examinations. An abdominal CT showed a low-density tumor of approximately 30 mm in the ascending colon, and the CT density inside the tumor was same as that of fatty tissues. A subsequent colonoscopy showed a submucosal tumor (SMT) in the proximal ascending colon developing from the terminal ileum...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27834641/in-vivo-electrical-conductivity-contrast-imaging-in-a-mouse-model-of-cancer-using-high-frequency-magnetoacoustic-tomography-with-magnetic-induction-hfmat-mi
#12
Kai Yu, Qi Shao, Shai Ashkenazi, John C Bischof, Bin He
Cancerous tissues have electrical-conductivity signatures different from normal tissues, which contain potentially useful information for early detection. Despite recent advancements in electrical-conductivity imaging and its applications, imaging electrical conductivities with high spatial resolution remains a challenge for non-invasive diagnosis of early-stage cancer. Among the various electrical-conductivity imaging methods, magnetoacoustic tomography with magnetic induction (MAT-MI) is a promising technology for non-invasive detection of breast cancer...
October 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27829404/investigation-of-optical-coherence-micro-elastography-as-a-method-to-visualize-micro-architecture-in-human-axillary-lymph-nodes
#13
Kelsey M Kennedy, Lixin Chin, Philip Wijesinghe, Robert A McLaughlin, Bruce Latham, David D Sampson, Christobel M Saunders, Brendan F Kennedy
BACKGROUND: Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale mechanical properties of lymph nodes could, thus, provide diagnostic information to aid in the assessment of lymph node involvement in metastatic cancer...
November 9, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27818949/the-necrosis-avid-small-molecule-hq4-dtpa-as-a-multimodal-imaging-agent-for-monitoring-radiation-therapy-induced-tumor-cell-death
#14
Marieke A Stammes, Azusa Maeda, Jiachuan Bu, Deborah A Scollard, Iris Kulbatski, Philip J Medeiros, Riccardo Sinisi, Elena A Dubikovskaya, Thomas J A Snoeks, Ermond R van Beek, Alan B Chan, Clemens W G M Löwik, Ralph S DaCosta
PURPOSE: Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring early response to antitumor therapies. To facilitate this, we previously developed a biocompatible necrosis-avid near-infrared fluorescence (NIRF) imaging probe, HQ4, which was radiolabeled with (111)Indium-chloride ((111)In-Cl3) via the chelate diethylene triamine pentaacetic acid (DTPA), to enable clinical translation. The aim of the present study was to evaluate the application of HQ4-DTPA for monitoring tumor cell death induced by radiation therapy...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27815661/improved-radiosynthesis-and-biological-evaluations-of-l-and-d-1-18-f-fluoroethyl-tryptophan-for-pet-imaging-of-ido-mediated-kynurenine-pathway-of-tryptophan-metabolism
#15
Yangchun Xin, Hancheng Cai
PURPOSE: Tryptophan metabolism via indoleamine 2,3-dioxygenase (IDO)-mediated kynurenine pathway plays a role in immunomodulation and has been emerging as a plausible target for cancer immunotherapy. Imaging IDO-mediated kynurenine pathway of tryptophan metabolism with positron emission tomography (PET) could provide valuable information for noninvasive assessment of cancer immunotherapy response. In this work, radiotracer 1-(2-[(18)F]fluoroethyl)-L-tryptophan (1-L-[(18)F]FETrp) and its enantioisomer 1-D-[(18)F]FETrp were synthesized and evaluated for PET imaging of IDO-mediated kynurenine pathway of tryptophan metabolism...
November 4, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27814633/mri-in-breast-cancer-radiotherapy-in-prone-and-supine-positions
#16
Lu Shang, Zewen Liu, Yi Rong, Tingyang Zhou, Li Zuo
Contemporary radiotherapy (RT) planning utilizes both a computed tomography (CT) scan either in prone or supine position with no breast compression or magnetic resonance imaging (MRI). The application of MRI is limited by image distortion and a lack of electron density information. The standard supine position not only exposes the tumor to RT non-homogenously, it can cause damage to the neighboring benign tissues. Here, we compare the effectiveness of both the prone and supine positions in breast cancer RT and various aspects of breast cancer treatment planning using MRI and CT...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27813620/occult-breast-primary-malignancy-presenting-as-isolated-axillary-lymph-node-metastasis-early-detection-of-primary-site-by-18f-fdg-pet-ct
#17
Ramya Soundararajan, Niraj Naswa, Sellam Karunanithi, Ritika Walia, Rakesh Kumar, Chandrasekhar Bal
Breast cancer patients rarely present with isolated axillary lymph node metastasis without any clinical or radiological evidence of primary tumor. Identification of the primary site of tumor helps in planning appropriate patient management which has definite impact on patient's survival. We present here a case of 30-year-old female who presented with isolated right axillary lymph node metastasis with no evidence of primary tumor clinically. Conventional imaging modalities were negative for primary site. She underwent whole body 18F-Flurodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and it contributed significantly in early detection of occult primary tumor in right breast...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27812027/in-vivo-bioluminescence-tomography-for-monitoring-breast-tumor-growth-and-metastatic-spreading-comparative-study-and-mathematical-modeling
#18
Séverine Mollard, Raphaelle Fanciullino, Sarah Giacometti, Cindy Serdjebi, Sebastien Benzekry, Joseph Ciccolini
This study aimed at evaluating the reliability and precision of Diffuse Luminescent Imaging Tomography (DLIT) for monitoring primary tumor and metastatic spreading in breast cancer mice, and to develop a biomathematical model to describe the collected data. Using orthotopic mammary fat pad model of breast cancer (MDAMB231-Luc) in mice, we monitored tumor and metastatic spreading by three-dimensional (3D) bioluminescence and cross-validated it with standard bioluminescence imaging, caliper measurement and necropsy examination...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27807507/sarcoidosis-imitating-breast-cancer-metastasis-a-case-report-and-literature-review
#19
Teimuraz Kochoyan, Mobil Akhmedov, Alexander Shabanov, Ilya Terekhov
Sarcoidosis is a benign systematic granulomatous disorder of unknown etiology and is associated with various malignancies. However, granulomatous and metastatic lymph node lesions are difficult to distinguish even when using precise and modern diagnostic methods, such as positron emission tomography. Thus, histological verification is the only method that can be used to accurately describe the nature of this disease. In this article, we report a case of non-luminal HER-2/neu-positive breast cancer in a patient without history of sarcoidosis and suspected to have metastatic disease...
September 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/27805423/the-potential-of-multiparametric-mri-of-the-breast
#20
Katja Pinker, Thomas H Helbich, Elizabeth A Morris
Magnetic resonance imaging (MRI) is an essential tool in breast imaging, with multiple established indications. Dynamic contrast-enhanced MRI (DCE-MRI) is the backbone of any breast MRI protocol and has an excellent sensitivity and good specificity for breast cancer diagnosis. DCE-MRI provides high-resolution morphological information, as well as some functional information about neo-angiogenesis as a tumour-specific feature. To overcome limitations in specificity, several other functional MRI parameters have been investigated and the application of these combined parameters is defined as multiparametric MRI (mpMRI) of the breast...
November 2, 2016: British Journal of Radiology
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