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https://www.readbyqxmd.com/read/29458193/attenuation-of-neuro-inflammation-improves-survival-and-neurodegeneration-in-a-mouse-model-of-severe-neonatal-hyperbilirubinemia
#1
Simone Vodret, Giulia Bortolussi, Alessandra Iaconcig, Elena Martinelli, Claudio Tiribelli, Andrés F Muro
All pre-term newborns and a high proportion of term newborns develop neonatal jaundice. Neonatal jaundice is usually a benign condition and self-resolves within few days after birth. However, a combination of unfavorable complications may lead to acute hyperbilirubinemia. Excessive hyperbilirubinemia may be toxic for the developing nervous system leading to severe neurological damage and death by kernicterus. Survivors show irreversible neurological deficits such as motor, sensitive and cognitive abnormalities...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29457638/a-dialectical-behavior-therapy-skills-intervention-for-women-with-suicidal-behaviors-in-rural-nepal-a-single-case-experimental-design-series
#2
Megan K Ramaiya, Caitlin McLean, Upasana Regmi, Devika Fiorillo, Clive J Robins, Brandon A Kohrt
BACKGROUND: Suicide in low- and middle-income countries (LMICs) accounts for 75% of the world's burden of suicide mortality and is the leading single cause of death among Nepali reproductive age women. To advance treatment for suicidal behaviors in LMICs, a single-case experimental design (SCED) was conducted of a culturally adapted Dialectical Behavior Therapy skills intervention for Nepali populations (DBT-N). METHOD: Ten Nepali women with histories of suicidality participated in the 10-session intervention...
February 19, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29457592/pegylated-graphene-oxide-fe3o4-nanocomposite-synthesis-characterization-and-evaluation-of-its-performance-as-de-novo-drug-delivery-nanosystem
#3
Abbas Jafarizad, Ali Taghizadehgh-Alehjougi, Morteza Eskandani, Maryam Hatamzadeh, Mojtaba Abbasian, Rahim Mohammad-Rezaei, Maryam Mohammadzadeh, Başak Toğar, Mehdi Jaymand
This paper describes the development of mitoxantrone-loaded PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4-MTX), and investigation of its preliminary drug delivery performance. For this, the GO was synthesized through oxidizing graphite powder, and subsequently carboxylated using a substitution nucleophilic reaction. The carboxylated GO (GO-COOH) was then conjugated with amine end-caped PEG chains by Steglich esterification. Afterward, GO-PEG/Fe3O4 nanocomposite was synthesized through the anchoring of Fe3O4 nanoparticles onto the surface of GO-PEG during the sonication...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457449/catalytically-active-single-chain-polymeric-nanoparticles-exploring-their-functions-in-complex-biological-media
#4
Yiliu Liu, Silvia Pujals, Patrick J M Stals, Thomas Pauloehrl, Stanislav I Presolski, E W Meijer, Lorenzo Albertazzi, Anja R A Palmans
Dynamic single-chain polymeric nanoparticles (SCPNs) are intriguing, bioinspired architectures that result from the collapse or folding of an individual polymer chain into a nanometer-sized particle. Here we present a detailed biophysical study on the behavior of dynamic SCPNs in living cells and an evaluation of their catalytic functionality in such a complex medium. We first developed a number of delivery strategies that allowed the selective localization of SCPNs in different cellular compartments. Live/dead tests showed that the SCPNs were not toxic to cells while spectral imaging revealed that SCPNs provide a structural shielding and reduced the influence from the outer biological media...
February 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29457252/body-image-flexibility-a-predictor-and-moderator-of-outcome-in-transdiagnostic-outpatient-eating-disorder-treatment
#5
Mia L Pellizzer, Glenn Waller, Tracey D Wade
OBJECTIVE: Predictors of attrition and predictors and moderators of outcome were explored in a transdiagnostic sample of patients who received ten-session cognitive behavioral therapy (CBT-T) for nonunderweight eating disorders. Body image flexibility, a protective positive body image construct, was hypothesized to be a significant moderator. METHOD: Data from two case series were combined to form a sample of 78 participants who received CBT-T. Baseline measures of body image, negative affect, personality, and motivation (readiness to change and self-efficacy) were included as potential predictors...
February 19, 2018: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29457128/evaluation-of-hydrogels-presenting-extracellular-matrix-derived-adhesion-peptides-and-encapsulating-cardiac-progenitor-cells-for-cardiac-repair
#6
Srishti Bhutani, Aline L Y Nachlas, Milton E Brown, Tionne Pete, Christopher T Johnson, Andres J García, Michael E Davis
Cell therapy is an emerging paradigm for the treatment of heart disease. In spite of the exciting and promising preclinical results, the benefits of cell therapy for cardiac repair in patients have been modest at best. Biomaterials-based approaches may overcome the barriers of poor differentiation and retention of transplanted cells. In this study, we prepared and tested hydrogels presenting extracellular matrix (ECM)-derived adhesion peptides as delivery vehicles for c-kit+ cardiac progenitor cells (CPCs)...
January 8, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29456984/the-efficacy-of-internet-based-cognitive-behavioral-therapy-on-the-anxiety-disorders-among-adolescent-girls
#7
Afsaneh Karbasi, Azadeh Haratian
Background: The prevalence of anxiety disorders among children and adolescents are found to be approximately between 8-12 and 5-10, respectively, and the long-lasting effects of such disorders can expose the sufferers to impairment and dysfunction in several areas of life the examples of which are poor educational performance, low self-esteem, and depression. The present study aims to evaluate the efficacy of internet-based, cognitive-behavioral therapy (ICBT) in treating the anxiety disorders among adolescent females...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456927/best-practices-in-supervising-cognitive-behavioral-therapy-with-youth
#8
REVIEW
Robert D Friedberg
Clinical supervision of cognitive behavioral therapy (CBT) with youth ensures better patient care and fosters trainees' professional development. However, often insufficient attention is directed toward disseminating best practices in supervision of CBT with youth. This Therapeutic Advances contribution aims to communicate the core content of supervision. Additionally, the key supervisory practices associated with CBT with youth are described. Supervisory outcomes are summarized and recommendations for supervisory practices are made...
February 8, 2018: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/29456128/transcranial-direct-current-stimulation-and-constraint-induced-therapy-in-cerebral-palsy-a-randomized-blinded-sham-controlled-clinical-trial
#9
Bernadette Gillick, Tonya Rich, Samuel Nemanich, Chao-Ying Chen, Jeremiah Menk, Bryon Mueller, Mo Chen, Marcie Ward, Gregg Meekins, Tim Feyma, Linda Krach, Kyle Rudser
We investigated the safety, feasibility, and efficacy of transcranial direct current stimulation (tDCS) combined with constraint-induced movement therapy (CIMT) in children and young adults with unilateral cerebral palsy. Twenty participants were randomized to receive active or sham tDCS. The intervention consisted of 10 consecutive weekday sessions of tDCS applied to the non-lesioned hemisphere (20 min) concurrently with CIMT (120 min). Participants, caregivers, and interventionists were blinded to group assignment...
February 11, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29455696/targeting-habits-in-anorexia-nervosa-a-proof-of-concept-randomized-trial
#10
Joanna E Steinglass, Deborah R Glasofer, Emily Walsh, Gabby Guzman, Carol B Peterson, B Timothy Walsh, Evelyn Attia, Stephen A Wonderlich
BACKGROUND: Habits are behavioral routines that are automatic and frequent, relatively independent of any desired outcome, and have potent antecedent cues. Among individuals with anorexia nervosa (AN), behaviors that promote the starved state appear habitual, and this is the foundation of a recent neurobiological model of AN. In this proof-of-concept study, we tested the habit model of AN by examining the impact of an intervention focused on antecedent cues for eating disorder routines...
February 19, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29454881/curcumin-treatment-leads-to-better-cognitive-and-mood-function-in-a-model-of-gulf-war-illness-with-enhanced-neurogenesis-and-alleviation-of-inflammation-and-mitochondrial-dysfunction-in-the-hippocampus
#11
M Kodali, B Hattiangady, G A Shetty, A Bates, B Shuai, A K Shetty
Diminished cognitive and mood function are among the most conspicuous symptoms of Gulf WarIllness(GWI). Our previous studies in a rat model of GWI have demonstrated that persistent cognitive and mood impairments are associated with substantially declined neurogenesis, chronic low-grade inflammation, increased oxidative stress and mitochondrial dysfunction in the hippocampus. We tested the efficacy of curcumin (CUR) to maintain better cognitive and mood function in a rat model of GWI because of its neurogenic, antiinflammatory, antioxidant, and memory and mood enhancing properties...
February 15, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29454374/effects-of-umbilical-cord-blood-cells-and-subtypes-to-reduce-neuroinflammation-following-perinatal-hypoxic-ischemic-brain-injury
#12
Courtney A McDonald, Tayla R Penny, Madison C B Paton, Amy E Sutherland, Lakshmi Nekkanti, Tamara Yawno, Margie Castillo-Melendez, Michael C Fahey, Nicole M Jones, Graham Jenkin, Suzanne L Miller
BACKGROUND: It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, the most prevalent cause of chronic disability in children. Recently, human clinical trials have reported safety and some efficacy following treatment of cerebral palsy using umbilical cord blood (UCB) cells. UCB is made up of many different cell types, including endothelial progenitor cells (EPCs), T regulatory cells (Tregs), and monocyte-derived suppressor cells (MDSCs)...
February 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29454255/effects-of-adjunctive-eslicarbazepine-acetate-on-neurocognitive-functioning-in-children-with-refractory-focal-onset-seizures
#13
Sergiusz Jóźwiak, P Veggiotti, J Moreira, H Gama, F Rocha, P Soares-da-Silva
PURPOSE: This was a phase-II, randomized, double-blind (DB), placebo-controlled study aimed to evaluate neurocognitive effects of eslicarbazepine acetate (ESL) as adjunctive therapy in pediatric patients with refractory focal-onset seizures (FOS). METHODS: Children (6-16years old) with FOS were randomized (2:1) to ESL or placebo. Treatment started at 10mg/kg/day, was up-titrated up to 30mg/kg/day (target dose), and maintained for 8weeks, followed by one-year open-label follow-up...
February 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29454196/sexually-transmitted-infections-and-immune-activation-among-hiv-infected-but-virally-suppressed-youth-on-antiretroviral-therapy
#14
Tanya L Kowalczyk Mullins, Su X Li, James Bethel, Maureen M Goodenow, Stephanie Hudey, John W Sleasman
BACKGROUND: Human immunodeficiency virus (HIV) infection is associated with chronic immune activation, and concurrent sexually transmitted infections (STIs) may increase immune activation. OBJECTIVES: Because HIV-infected youth are at high risk of STIs and little is known about the impact of STIs on immune activation in HIV-infected youth, we conducted an exploratory study examining the association between STIs and systemic inflammation and immune activation among HIV-infected adolescents...
February 7, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29453745/investigating-the-effectiveness-acceptability-and-impact-on-healthcare-usage-of-providing-a-cognitive-behavioural-based-psychological-therapy-service-for-patients-with-primary-antibody-deficiency
#15
Mari Campbell, Alex Clarke, Andrew Symes, Sarita Workman, Hans Stauss, A David Webster
PURPOSE: Patients with primary antibody deficiency report poorer quality of life and higher rates of anxiety and depression than the general population. Cognitive-behavioral therapy has been shown to be a valuable treatment for patients with other long-term physical health conditions, improving well-being and enabling them to manage their symptoms more effectively. The aim of this project was to establish the feasibility and effectiveness of providing cognitive-behavioral based therapy to patients with primary antibody deficiency...
February 17, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29453114/levetiracetam-monotherapy-for-the-treatment-of-infants-with-epilepsy
#16
Pinar Arican, Pinar Gencpinar, Dilek Cavusoglu, Nihal Olgac Dundar
PURPOSE: Levetiracetam is a broad-spectrum anti-epileptic drug that is effective against both focal and generalized epilepsies. In this study, we aimed to evaluate the efficacy, tolerability and safety of levetiracetam monotherapy in the management of different seizure types in children with epilepsy under the age of two. METHOD: This retrospective study was conducted on children with a diagnosis of epilepsy from January 2014 to January 2017. To be included in the study, patients were required to be less than two years of age at the time levetiracetam was initiated as initial monotherapy and to be followed clinically for at least 6 months...
February 12, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29452980/association-between-smoking-cessation-and-weight-gain-in-treatment-seeking-african-americans
#17
Marcia M Tan, Kolawole S Okuyemi, Ken Resnicow, Noella A Dietz, Michael H Antoni, Monica Webb Hooper
INTRODUCTION: Research has shown that African Americans gain more than average weight after smoking cessation. However, African Americans have been underrepresented in post-cessation weight gain research. The current study examined 1) the pattern of weight gain and 2) the association between smoking status and weight gain in a sample of African Americans seeking smoking cessation treatment. METHODS: Data were drawn from a randomized controlled trial testing the efficacy of a 4-week culturally specific smoking cessation cognitive behavioral therapy (CBT) intervention among African American smokers (N = 342)...
February 3, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29452685/behavioural-outcomes-of-subthalamic-stimulation-and-medical-therapy-versus-medical-therapy-alone-for-parkinson-s-disease-with-early-motor-complications-earlystim-trial-secondary-analysis-of-an-open-label-randomised-trial
#18
Eugénie Lhommée, Lars Wojtecki, Virginie Czernecki, Karsten Witt, Franziska Maier, Lisa Tonder, Lars Timmermann, Thomas D Hälbig, Fanny Pineau, Franck Durif, Tatiana Witjas, Marcus Pinsker, Maximilian Mehdorn, Friederike Sixel-Döring, Andreas Kupsch, Rejko Krüger, Saskia Elben, Stephan Chabardès, Stéphane Thobois, Christine Brefel-Courbon, Fabienne Ory-Magne, Jean-Marie Regis, David Maltête, Anne Sauvaget, Jörn Rau, Alfons Schnitzler, Michael Schüpbach, Carmen Schade-Brittinger, Gunther Deuschl, Jean-Luc Houeto, Paul Krack
BACKGROUND: Although subthalamic stimulation is a recognised treatment for motor complications in Parkinson's disease, reports on behavioural outcomes are controversial, which represents a major challenge when counselling candidates for subthalamic stimulation. We aimed to assess changes in behaviour in patients with Parkinson's disease receiving combined treatment with subthalamic stimulation and medical therapy over a 2-year follow-up period as compared with the behavioural evolution under medical therapy alone...
March 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29452666/transformation-of-follicular-lymphoma-why-does-it-happen-and-can-it-be-prevented
#19
REVIEW
Brian K Link
Follicular lymphoma is a clinical disease with a multitude of presentations and behaviors. Although infrequent, transformation of follicular lymphoma to a more aggressive behaving subtype - prototypically diffuse large B-cell lymphoma - confers a substantially adverse prognosis. There is no consensus for optimal management after transformation is recognized. Historically considered a distinct clinical event, this review highlights the multiple subclinical transformational events that either variably or cumulatively result in clinical recognition of transformed follicular lymphoma...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29452418/phf20-collaborates-with-parp1-to-promote-stemness-and-aggressiveness-of-neuroblastoma-cells-through-activation-of-sox2-and-oct4
#20
Wenyong Long, Wei Zhao, Bo Ning, Jing Huang, Junjun Chu, Linfeng Li, Qianquan Ma, Changsheng Xing, Helen Y Wang, Qing Liu, Rong-Fu Wang
The differentiation status of neuroblastoma (NB) strongly correlates with its clinical outcomes; however, the molecular mechanisms driving maintenance of stemness and differentiation remain poorly understood. Here, we show that plant homeodomain finger-containing protein 20 (PHF20) functions as a critical epigenetic regulator in sustaining stem cell-like phenotype of NB by using CRISPR/Cas9-based targeted knockout (KO) for high-throughput screening of gene function in NB cell differentiation. Expression of PHF20 in NB was significantly associated with high aggressiveness of the tumor and poor outcomes for NB patients...
February 14, 2018: Journal of Molecular Cell Biology
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