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https://www.readbyqxmd.com/read/28350469/synthesis-of-sugar-boronic-acid-derivatives-a-class-of-potential-agents-for-boron-neutron-capture-therapy
#1
Daniela Imperio, Erika Del Grosso, Silvia Fallarini, Grazia Lombardi, Luigi Panza
To date, sugar analogues that contain boronic acids as substitutes for hydroxyl groups are a class of compounds nearly unknown in the literature. The challenging synthesis of two sugar-boronic acid analogues is described, and data are retrieved on their solution behavior, stability, and toxicity. As these compounds were expected to mimic the behavior of carbohydrates, they were tested in regards to their future development as potential boron neutron capture therapy agents.
March 28, 2017: Organic Letters
https://www.readbyqxmd.com/read/28350451/ros-switchable-polymeric-nanoplatform-with-stimuli-responsive-release-for-active-targeted-drug-delivery-to-breast-cancer
#2
Yu Zhang, Qin Guo, Sai An, Yifei Lu, Jianfeng Li, Xi He, Lisha Liu, Yujie Zhang, Tao Sun, Chen Jiang
Tumor microenvironment plays a vital role in the process of tumor development, proliferation, invasion, and metastasis. It is well acknowledged that reduction in pH, reactive oxygen species (ROS), and increased level of glucose transporter 1 (GLUT1) have become featured intracellular and extracellular biochemical markers of cancer owing to oncogenic transformation and abnormal metabolism. To establish a distinctive drug delivery system directed against the tumor microenvironment features, we develop a newly engineered polymeric nanoplatform for efficient doxorubicin (DOX) delivery with reduced systemic toxicity and high antitumor efficiency...
March 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28346923/gut-brain-axis-and-behavior
#3
Clair R Martin, Emeran A Mayer
In the last 5 years, interest in the interactions among the gut microbiome, brain, and behavior has exploded. Preclinical evidence supports a role of the gut microbiome in behavioral responses associated with pain, emotion, social interactions, and food intake. Limited, but growing, clinical evidence comes primarily from associations of gut microbial composition and function to behavioral and clinical features and brain structure and function. Converging evidence suggests that the brain and the gut microbiota are in bidirectional communication...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346889/quantifying-the-dynamics-of-emotional-expressions-in-family-therapy-of-patients-with-anorexia-nervosa
#4
Laurent Pezard, Karyn Doba, Annick Lesne, Jean-Louis Nandrino
Emotional interactions have been considered dynamical processes involved in the affective life of humans and their disturbances may induce mental disorders. Most studies of emotional interactions have focused on dyadic behaviors or self-reports of emotional states but neglected the dynamical processes involved in family therapy. The main objective of this study is to quantify the dynamics of emotional expressions and their changes using the family therapy of patients with anorexia nervosa as an example. Nonlinear methods characterize the variability of the dynamics at the level of the whole therapeutic system and reciprocal influence between the participants during family therapy...
March 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28346384/intensive-sleep-re-training-from-bench-to-bedside
#5
REVIEW
Leon Lack, Hannah Scott, Gorica Micic, Nicole Lovato
Intensive sleep re-training is a promising new therapy for chronic insomnia. Therapy is completed over a 24-h period during a state of sleep deprivation. Improvements of sleep and daytime impairments are comparable to the use of stimulus control therapy but with the advantage of a rapid reversal of the insomnia. The initial studies have been laboratory based and not readily accessible to the patient population. However, new smart phone technology, using a behavioral response to external stimuli as a measure of sleep/wake state instead of EEG determination of sleep, has made this new therapy readily available...
March 27, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28346077/effects-of-brief-messages-about-antiretroviral-therapy-and-condom-use-benefits-among-black-and-latino-msm-in-three-us-cities
#6
Jeffrey H Herbst, Gordon Mansergh, Nicole Pitts, Damian Denson, Matthew J Mimiaga, Jeremy Holman
This pilot study examined effects of HIV prevention messages about self and partner benefits of antiretroviral therapy (ART) and condom effectiveness on increased intentions for behavior change. Data were from Messages4Men, a study examining prevention messages among 320 HIV-positive and 605 HIV-negative black and Latino MSM. Men completed a computer-based assessment after message exposure, and multivariable models controlled for risky sex and demographics. A majority of HIV-positive men reported increased intentions for ART use; 22% reported partner benefit information was new...
March 27, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28346056/alcohol-and-drug-use-and-aberrant-drug-related-behavior-among-patients-on-chronic-opioid-therapy
#7
Cynthia I Campbell, Andrea H Kline-Simon, Michael Von Korff, Kathleen W Saunders, Constance Weisner
OBJECTIVE: To better identify individuals on chronic opioid therapy (COT) at high risk for aberrant-drug related behavior (ADRB). We examine whether patients with low level alcohol and drug use have similar characteristics to those with alcohol and drug disorders. We then examined the relationship of alcohol and drug use to ADRBs among COT patients. METHODS: The sample was 972 randomly selected COT patients (age 21-80 years old) from a large health system in Northern California, USA, and interviewed in 2009...
March 27, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28346039/comparison-between-urinalysis-results-and-self-reported-heroin-use-among-patients-undergoing-methadone-maintenance-treatment-in-china
#8
Li Li, Li-Jung Liang, Chunqing Lin, Nan Feng, Zunyou Wu
BACKGROUND: The validity and concordance of two main measures of drug use behavior, self-report and urinalysis, has long been discussed. More understanding is needed about the underlying factors associated with discordance between these two methods. OBJECTIVES: Describe the pattern and associated factors of discordance between self-reported heroin use and the urinalysis results of opiate use among methadone maintenance therapy (MMT) patients in China. METHODS: A total of 2,448 MMT patients from 68 clinics in five provinces of China participated in a survey, which collected information on demographics, drug use and MMT-related factors, depressive symptoms, and drug avoidance self-efficacy...
March 27, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28345961/the-short-term-efficacy-of-an-unguided-internet-based-cognitive-behavioral-therapy-for-insomnia-a-randomized-controlled-trial-with-a-six-month-nonrandomized-follow-up
#9
Susanne Hagatun, Øystein Vedaa, Tine Nordgreen, Otto R F Smith, Ståle Pallesen, Odd E Havik, Bjørn Bjorvatn, Frances P Thorndike, Lee M Ritterband, Børge Sivertsen
OBJECTIVE: Insomnia is a major health problem, and the need for effective and accessible treatment is urgent. The aim of the current study was to evaluate the short-term efficacy of an unguided Internet-based cognitive-behavioral treatment program for insomnia (CBTi), called SHUTi (Sleep Healthy Using the Internet). METHODS: This study used a parallel arm randomized controlled trial in Norway. Participants were randomly allocated to the SHUTi condition or a Web-based patient education condition...
March 27, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28345442/predicting-1-year-statin-adherence-among-prevalent-users-a-retrospective-cohort-study
#10
Alexis A Krumme, Jessica M Franklin, Danielle L Isaman, Olga S Matlin, Angela Y Tong, Claire M Spettell, Troyen A Brennan, William H Shrank, Niteesh K Choudhry
BACKGROUND: Attempts to predict who is at risk of future nonadherence have largely focused on predictions at the time of therapy initiation; however, these users are only a small proportion of all patients on therapy at any point in time. Methods to predict nonadherence for established medication users, which have not been previously described in the literature, would be helpful to guide efforts to enhance the use of evidence-based therapies. OBJECTIVE: To test approaches for adherence prediction among prevalent statin users, namely the use of short-term filling behavior, investigator-specified predictors from medical and pharmacy administrative claims, and the empirical selection of potential predictors using the high-dimensional propensity score variable selection algorithm...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28344131/specific-patterns-of-spinal-metabolites-underlying-%C3%AE-me-5-ht-evoked-pruritus-compared-with-histamine-and-capsaicin-assessed-by-proton-nuclear-magnetic-resonance-spectroscopy
#11
Taotao Liu, Zhigang He, Xuebi Tian, Ghulam Mustafa Kamal, Zhixiao Li, Zeyuan Liu, Huili Liu, Fuqiang Xu, Jie Wang, Hongbing Xiang
The mechanism behind itching is not well understood. Proton nuclear magnetic resonance ((1)H-NMR) spectroscopic analysis of spinal cord extracts provides a quick modality for evaluating the specific metabolic activity of α-Me-5-HT-evoked pruritus mice. In the current study, four groups of young adult male C57Bl/6 mice were investigated; one group treated with saline, while the other groups intradermally injected with α-Me-5-HT (histamine independent pruritogen), histamine (histamine dependent pruritogen) and capsaicin (algogenic substance), respectively...
March 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28343943/insomnia-treatment-preferences-during-pregnancy
#12
Ivan D Sedov, Sherryl H Goodman, Lianne M Tomfohr-Madsen
OBJECTIVE: To determine pregnant women's preferences for the treatment of insomnia: cognitive behavioral therapy (CBT-I), pharmacotherapy, or acupuncture. DESIGN: A cross-sectional survey of pregnant women. SETTING: We recruited participants in person at a low-risk maternity clinic and a pregnancy and infant trade show and invited them to complete an online questionnaire. PARTICIPANTS: The sample (N = 187) was primarily White (70%), married or common-law married (96%), and on average 31 years of age; the mean gestational age was 28 weeks...
March 24, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28343447/the-undifferentiated-carcinoma-that-became-a-melanoma-re-biopsy-of-a-cancer-of-an-unknown-primary-site-a-case-report
#13
Oluf Dimitri Røe, Sissel Gyrid Freim Wahl
BACKGROUND: Cancer of unknown primary site is still a demanding condition as it is per definition metastatic, with heterogeneous biological behavior, and it is often resistant to therapy. Cancer of unknown primary site accounts for approximately 1 to 5 % of all cancers, but is currently among the top six causes of cancer deaths in Western countries. To correctly identify the biological origin of the tumor, a large spectrum of differential diagnoses must be considered and scrutinized. At progression, re-biopsy might be necessary to reveal the true origin of the tumor or actionable targets...
March 27, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28343223/sildenafil-enhances-quantity-of-immature-neurons-and-promotes-functional-recovery-in-the-developing-ischemic-mouse-brain
#14
Jonas Engels, Natalie Elting, Lisa Braun, Ivo Bendix, Josephine Herz, Ursula Felderhoff-Müser, Mark Dzietko
BACKGROUND: Hypoxic-ischemic (HI) injury to the developing brain occurs in 1 out of 1,000 live births and remains a major cause of significant morbidity and mortality. A large number of survivors suffer from long-term sequelae including seizures and neurological deficits. However, the pathophysiological mechanisms of recovery after HI insult are not clearly understood, and preventive measures or clinical treatments are nonexistent or not sufficiently effective in the clinical setting...
March 25, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28343052/season-of-treatment-initiation-with-antidepressants-and-suicidal-behavior-a-population-based-cohort-study-in-sweden
#15
Georgios D Makris, Johan Reutfors, Morten Andersen, Richard A White, Lisa Ekselius, Fotios C Papadopoulos
BACKGROUND: Decreased binding capacity of SERT in the prefrontal cortex has been observed in both suicide victims and suicide attempters. Moreover, some studies have shown that SERT has a seasonal variation with lower binding capacity in the spring and summer, which coincides with a seasonal peak of suicides. Our aim was to explore whether the season of treatment initiation with antidepressants is associated with suicide or suicide attempt and compare it with the underlying suicide seasonality in the general population...
March 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28342947/what-good-are-positive-emotions-for-treatment-trait-positive-emotionality-predicts-response-to-cognitive-behavioral-therapy-for-anxiety
#16
Charles T Taylor, Sarah E Knapp, Jessica A Bomyea, Holly J Ramsawh, Martin P Paulus, Murray B Stein
OBJECTIVE: Cognitive behavioral therapy (CBT) is empirically supported for the treatment of anxiety disorders; however, not all individuals achieve recovery following CBT. Positive emotions serve a number of functions that theoretically should facilitate response to CBT - they promote flexible patterns of information processing and assimilation of new information, encourage approach-oriented behavior, and speed physiological recovery from negative emotions. We conducted a secondary analysis of an existing clinical trial dataset to test the a priori hypothesis that individual differences in trait positive emotions would predict CBT response for anxiety...
March 22, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28342404/cognitive-behavioural-therapy-and-mindfulness-based-stress-reduction-may-be-equally-effective-in-reducing-anxiety-and-depression-in-adults-with-autism-spectrum-disorders
#17
Bram B Sizoo, Erik Kuiper
Anxiety and depression co-occur in 50-70% of adults with autism spectrum disorder (ASD) but treatment methods for these comorbid problems have not been systematically studied. Recently, two ASD-tailored protocols were published: mindfulness based stress reduction (MBSR) and cognitive behavioural therapy (CBT). We wanted to investigate if both methods are equally effective in reducing anxiety and depression symptoms among adults with ASD. 59 adults with ASD and anxiety or depression scores above 7 on the Hospital Anxiety and Depression Scale, gave informed consent to participate; 27 followed the CBT protocol, and 32 the MBSR treatment protocol...
March 22, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28342269/acral-lentiginous-melanoma-versus-other-melanoma-a-single-center-analysis-in-japan
#18
Maiko Wada, Takamichi Ito, Gaku Tsuji, Takeshi Nakahara, Akihito Hagihara, Masutaka Furue, Hiroshi Uchi
We summarize herein our 14-year experience of conventional treatment outcomes before the era of molecular-targeted therapy and immunotherapy. Specifically, we conducted a retrospective review of our 252 patients with primary cutaneous melanoma (acral lentiginous melanoma [ALM], n = 121; non-acral lentiginous melanoma [non-ALM], n = 131), and compared the prognostic factors between ALM and non-ALM. Melanoma-specific survival and disease-free survival were estimated using the Kaplan-Meier method. Regarding the results, all patients were Japanese (106 male and 146 female), with a mean age of 60...
March 24, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28341617/internet-delivered-health-interventions-that-work-systematic-review-of-meta-analyses-and-evaluation-of-website-availability
#19
Mary Am Rogers, Kelsey Lemmen, Rachel Kramer, Jason Mann, Vineet Chopra
BACKGROUND: Due to easy access and low cost, Internet-delivered therapies offer an attractive alternative to improving health. Although numerous websites contain health-related information, finding evidence-based programs (as demonstrated through randomized controlled trials, RCTs) can be challenging. We sought to bridge the divide between the knowledge gained from RCTs and communication of the results by conducting a global systematic review and analyzing the availability of evidence-based Internet health programs...
March 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28341611/extinction-memory-is-facilitated-by-methylphenidate-and-regulated-by-dopamine-and-noradrenaline-receptors
#20
Cristiane R G Furini, Jonny A K Behling, Carolina G Zinn, Mara Lize Zanini, Eduardo S Assis Brasil, Luiza Doro Pereira, Ivan Izquierdo, Jociane de C Myskiw
Extinction is defined as the learned inhibition of retrieval and is the mainstay of exposure therapy, which is widely used to treat drug addiction, phobias and fear disorders. The psychostimulant, methylphenidate (MPH) is known to increase extracellular levels of noradrenaline and dopamine by blocking their reuptake and studies have demonstrated that MPH can modulate hippocampal physiology and/or functions including long-term potentiation (LTP), learning and memory. However, the influence of MPH on fear extinction memory has been insufficiently studied...
March 21, 2017: Behavioural Brain Research
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