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https://www.readbyqxmd.com/read/29240757/rct-of-an-integrated-cbt-hiv-intervention-on-depressive-symptoms-and-hiv-risk
#1
Karin Tobin, Melissa A Davey-Rothwell, Bareng A S Nonyane, Amy Knowlton, Lawrence Wissow, Carl A Latkin
Depression and depressive symptoms mediate the association between drug use and HIV risk. Yet, there are few interventions that target depressive symptoms and HIV risk for people who use drugs (PWUD). This study was a randomized controlled trial of an integrated cognitive behavioral therapy and HIV prevention intervention to reduce depressive symptoms, injection risk behaviors and increase condom use in a sample of urban people who used heroin or cocaine in the prior 6 months. A total of 315 individuals aged 18-55, who self-reported at least one HIV drug and sex risk behavior and scored ≥16 and <40 on the Centers for Epidemiologic Studies-Depression (CES-D) scale were randomized using a two-block design, stratified by sex to ensure equivalent numbers, to a 10 session intervention arm (n = 162) or a single session control arm (n = 153)...
2017: PloS One
https://www.readbyqxmd.com/read/29240260/sohlh1-suppresses-glioblastoma-cell-proliferation-migration-and-invasion-by-inhibition-of-wnt-%C3%AE-catenin-signaling
#2
Xinyu Liu, Qing Gao, Na Zhao, Xiaoli Zhang, Weiwei Cui, Jinhao Sun, Jiang Fu, Jing Hao
Glioblastoma (GBM) is the most aggressive and highly invasive type of astrocytic tumors. Despite advances in diagnosis and therapy, the prognosis and survival time remain poor. Identifying key mediators of tumor cell proliferation, migration and invasion is crucial to the development of new and more effective therapies. In this paper, we report the novel role of Spermatogenesis- and oogenesis- specific basic helix-loop-helix transcription factor1 (Sohlh1) in the inhibition of Wnt/β-catenin signaling and aggressive behaviors in GBM cells...
December 14, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29239789/anterior-cingulate-volume-predicts-response-to-psychotherapy-and-functional-connectivity-with-the-inferior-parietal-cortex-in-major-depressive-disorder
#3
Fabio Sambataro, Nadja Doerig, Jürgen Hänggi, Robert Christian Wolf, Janis Brakowski, Martin Grosse Holtforth, Erich Seifritz, Simona Spinelli
In major depressive disorder (MDD), the anterior cingulate cortex (ACC) has been associated with clinical outcome as well as with antidepressant treatment response. Nonetheless, the association between individual differences in ACC structure and function and the response to cognitive behavioral therapy (CBT) is still unexplored. For this aim, twenty-five unmedicated patients with MDD were scanned with structural and resting state functional magnetic resonance imaging before the beginning of CBT treatment. ACC morphometry was correlated with clinical changes following psychotherapy...
November 24, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29239772/does-a-program-based-on-cognitive-behavioral-therapy-affect-kinesiophobia-in-patients-following-total-knee-arthroplasty-a%C3%A2-randomized-controlled-trial-with-a-6-month-follow-up
#4
Libai Cai, Huanhuan Gao, Huiping Xu, Yanyan Wang, Peihua Lyu, Yanjin Liu
BACKGROUND: To evaluate the effects of a cognitive behavioral therapy (CBT) program on kinesiophobia, knee function, pain and pain catastrophizing in patients following total knee arthroplasty (TKA). METHODS: This was a parallel-group, randomized, controlled pilot study in which 100 patients who exhibited kinesiophobia after TKA were randomly assigned to participate in a CBT (experimental group) or standard care (control group) program. Each group included 50 patients...
October 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29239627/clinical-severity-as-a-moderator-of-outcome-in-psychodynamic-and-dialectical-behavior-therapies-for-borderline-personality-disorder
#5
Zeynep Sahin, Bo Vinnars, Bernard S Gorman, Alexander Wilczek, Marie Åsberg, Jacques P Barber
The aim of the present study was to assess the effect of initial level of psychiatric severity on treatment outcome in psychodynamic therapy and dialectical behavior therapy (DBT) for borderline personality disorder (BPD). It was hypothesized that DBT would lead to better outcome for patients with high psychiatric severity, whereas dynamic treatment would lead to better outcome for patients with lower psychiatric severity. Data from the 5th-year follow-up of the Stockholm City Council's and the Karolinska Institute's Psychotherapy Project were used in the present study...
December 14, 2017: Personality Disorders
https://www.readbyqxmd.com/read/29238651/management-of-treatment-resistant-panic-disorder
#6
REVIEW
Giampaolo Perna, Daniela Caldirola
Purpose of Review: Purpose of Review Management of treatment-resistant (TR) panic disorder (PD) is an unresolved issue. In this paper, we provide a brief summary of previous findings, an updated (2015-2017) systematic review of pharmacological/non-pharmacological studies, and our personal perspective on this topic. Recent Findings: Recent Findings We found a very limited number of recent findings. Quetiapine extended-release augmentation has not been found to be beneficial, in comparison to placebo, in non-responders to previously recommended pharmacotherapy...
2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/29238372/transplantation-of-rat-mesenchymal-stem-cells-overexpressing-hypoxia-inducible-factor-2%C3%AE-improves-blood-perfusion-and-arteriogenesis-in-a-rat-hindlimb-ischemia-model
#7
Weifeng Lu, Xiaoli Chen, Yi Si, Shichai Hong, Zhengyu Shi, Weiguo Fu
Mesenchymal stem cells (MSCs) have been increasingly tested in cell-based therapy to treat numerous diseases. Genetic modification to improve MSC behavior may enhance posttransplantation outcome. This study aims to test the potential therapeutic benefits of rat bone marrow MSCs overexpressing hypoxia-inducible factor 2α (rMSCsHIF-2α ) in a rat hindlimb ischemia model. PBS, rMSCs, or rMSCsHIF-2α were injected into rat ischemic hindlimb. Compared with the injection of PBS or rMSCs, transplantation of rMSCsHIF-2α significantly improved blood perfusion, increased the number of vessel branches in the muscle of the ischemic hindlimb, and improved the foot mobility of the ischemic hindlimb (all P < 0...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29238317/therapeutic-self-disclosure-within-dbt-schema-therapy-and-cbasp-opportunities-and-challenges
#8
Stephan Köhler, Anne Guhn, Felix Betzler, Christian Stiglmayr, Eva-Lotta Brakemeier, Philipp Sterzer
In recent years, various therapeutic interventions have been established that extended behavior and cognitive behavior therapy (CBT) by so-called "third-wave" strategies. In order to address specific therapeutic challenges in certain subgroups of patients who do not sufficiently respond to "classical CBT," some of these third-wave strategies put particular emphasis on therapist self-disclosure. This article highlights therapeutic self-disclosure as a means to address interpersonal problems by comparing three third-wave strategies: (a) acceptance and change strategies as used in Dialectical Behavioral Therapy (DBT), (b) the concept of "limited reparenting" as used in Schema Therapy (ST), and (c) disciplined personal involvement as used in the Cognitive Behavioral Analysis System of Psychotherapy (CBASP)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29238235/oppositional-defiant-disorder-current-insight
#9
REVIEW
Abhishek Ghosh, Anirban Ray, Aniruddha Basu
Oppositional defiant disorder (ODD) is diagnosed broadly on the basis of frequent and persistent angry or irritable mood, argumentativeness/defiance, and vindictiveness. Since its inception in the third Diagnostic and Statistical Manual of Mental Disorders, epidemiological and longitudinal studies have strongly suggested a distinct existence of ODD that is different from other closely related externalizing disorders, with different course and outcome and possibly discrete subtypes. However, several issues, such as symptom threshold, dimensional versus categorical conceptualization, and sex-specific symptoms, are yet to be addressed...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/29238170/adherence-to-treatment-and-evaluation-of-disease-and-therapy-knowledge-in-lebanese-hypertensive-patients
#10
Hanine Abbas, Mazen Kurdi, Myriam Watfa, Rita Karam
Background: Adherence to treatment, healthy lifestyle, physical activities, smoking, diet, and salt intake are important factors to control for an effective decrease in blood pressure (BP) values for patients diagnosed with essential hypertension (HT). The aim of this work was to study the adherence to antihypertensive treatment and factors predicting this behavior in Lebanese patients. In addition, we evaluated the extent of patient's knowledge and perceptions about HT, risk factors, and medication side effects...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29238016/-imaging-of-bone-and-joint-destruction
#11
Junichi Kikuta, Masaru Ishii
  Osteoclasts are bone-resorbing giant polykaryons that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursors. We have originally established an advanced imaging system for visualizing in vivo behavior of osteoclasts and their precursors with intravital two-photon microscopy. By means of the system, we found that sphingosine-1-phosphate, a lipid mediator enriched in blood, controlled the migratory behavior of osteoclast precursors. We also developed pH-sensing chemical fluorescent probes to detect localized acidification by bone-resorbing osteoclasts on the bone surface in vivo, and identified two distinct functional states of differentiated osteoclasts, 'bone-resorptive' and 'non-resorptive'...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29237570/synergistic-enhancement-of-anticancer-therapeutic-efficacy-of-hpma-copolymer-doxorubicin-conjugates-via-combination-of-ligand-modification-and-stimuli-response-srategies
#12
Lian Li, Minglu Zhou, Yuan Huang
N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer has been extensively studied as drug carrier for tumor therapy. Due to the Enhanced Permeability and Retention (EPR) effect, HPMA copolymer drug conjugates are able to be passively accumulated in the tumor site. Currently, efficient uptake of this polymeric system by the cancer cells remains a big challenge, as HPMA polymer is highly hydrophilic, neutrally charged, and has low affinity towards cell membrane. In this study, selective and enhanced intracellular internalization of the copolymer-drug conjugates was achieved by utilizing a hybrid strategy including ligand modification and stimuli response...
December 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29237487/adolescent-coordinated-transition-act-to-improve-health-outcomes-among-young-people-living-with-hiv-in-nigeria-study-protocol-for-a-randomized-controlled-trial
#13
Nadia A Sam-Agudu, Jennifer R Pharr, Tamara Bruno, Chad L Cross, Llewellyn J Cornelius, Prosper Okonkwo, Bolanle Oyeledun, Hadiza Khamofu, Ayodotun Olutola, Salome Erekaha, William Nii Ayitey Menson, Echezona E Ezeanolue
BACKGROUND: Adolescents living with HIV (ALHIV) have worse health outcomes than other populations of people living with HIV. Contributing factors include lack of standard and comprehensive procedures for ALHIV transitioning from pediatric to adult care. This has contributed to poor retention at, and following transition, which is problematic especially in high ALHIV-burden, resource-limited settings like Nigeria. METHODS: Using a two-arm cluster randomized control design, the Adolescent Coordinated Transition (ACT) trial will measure the comparative effectiveness of a graduated transition and organized support group intervention against the usual practice of abrupt transfer of Nigerian ALHIV from pediatric to adult care...
December 14, 2017: Trials
https://www.readbyqxmd.com/read/29237208/-acceptance-and-commitment-therapy-in-the-treatment-of-chronic-disease
#14
Katharina Kuba, Gregor Weißflog
Acceptance and Commitment Therapy (ACT) is an intervention representing a transdiagnostic and contextual approach that assumes that psychological suffering is caused by experiential avoidance. The primary intention of ACT is not to eliminate symptoms and to treat mental disorders. Instead, ACT aims to increase psychological flexibility, i. e. to broaden the repertoire of cognitions and behaviors when facing inner and outer aversive events or experiences. Psychological flexibility can be enhanced by working with the 6 core components of the ACT model...
December 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29237186/-current-literature-overview-on-the-therapy-of-obesity-in-children-and-adolescents
#15
Jana Brauchmann, Susann Weihrauch-Blüher, Stefan Ehehalt, Susanna Wiegand
Background Obesity is a chronic disease due to the comorbidity associated with it and the need for long-term medical care. Therapeutic intervention is possible at every stage of pathophysiology. Aim The aim of the study is to demonstrate the effect of multimodal lifestyle interventions not only on the BMI/BMI-SDS, but also on (secondary) outcomes such as comorbidities, quality of life as well as the nutritional and movement behavior. Materials and Methods The literature database PubMed has been searched for internationally clinical studies on lifestyle interventions among 0 to 18-year-olds with overweight and obesity in the period from 01/01/2009 to 01/01/2016...
December 13, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29237039/development-of-a-brief-version-of-the-current-opioid-misuse-measure-comm-the-comm-9
#16
Stacey A McCaffrey, Ryan A Black, Albert J Villapiano, Robert N Jamison, Stephen F Butler
Objective: The Current Opioid Misuse Measure (COMM) is a commonly used self-report instrument to identify and monitor aberrant opioid-related behavior in chronic pain patients on opioid therapy. However, the length of the COMM may limit its clinical utility. Additionally, this paper-and-pencil screener requires hand scoring, which increases paperwork and staff burden. Therefore, the current study presents development of the "COMM-9," a brief electronically administered form of the COMM...
December 11, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29236528/role-of-clinical-neuropsychology-in-deep-brain-stimulation-review-of-the-literature-and-considerations-for-clinicians
#17
Joseph A Mole, Simon J Prangnell
Deep Brain Stimulation (DBS) is an effective surgical therapy for several neurological movement disorders. The clinical neuropsychologist has a well-established role in the neuropsychological evaluation and selection of surgical candidates. In this article, we argue that the clinical neuropsychologist's role is much broader, when considered in relation to applied psychologists' core competencies. We consider the role of the clinical neuropsychologist in DBS in relation to: assessment, formulation, evaluation and research, intervention or implementation, and communication...
December 13, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29235846/cu-ii-doped-polydopamine-coated-gold-nanorods-for-tumor-theranostics
#18
Shuwei Liu, Lu Wang, Min Lin, Dandan Wang, Ziqi Song, Shuyao Li, Rui Ge, Xue Zhang, Yi Liu, Zhimin Li, Hongchen Sun, Bai Yang, Hao Zhang
Gold nanorods (AuNRs) are potentially useful in tumor theranostics, but the poor stability, high toxicity, and rapid removal by the immune system seriously limit their theranostic applications. In our study, we demonstrate the fabrication of Cu(II)-doped polydopamine-coated AuNR (AuNR@CuPDA), which significantly improves the potentials in tumor theranostics. Besides the improvement of physiological stability and biocompatibility, the PDA shell increases the photothermal performance and prolongs the blood circulation time of AuNRs...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235615/-music-therapy-as-a-non-pharmacological-treatment-in-alzheimer-s-disease-a-systematic-review
#19
N Garcia-Casares, R M Moreno-Leiva, J A Garcia-Arnes
INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disease which involves, among other manifestations, a progressive deterioration of memory and language, as well as behavioral disorders. In addition to non-curative pharmacological therapies, for the last years, music therapy has been developed as an effective non-pharmacological therapy in order to relieve many of these manifestations. AIM: To analyze the recent scientific evidence about the effect of music therapy on cognitive and behavioral symptoms in patients with AD...
December 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/29235186/improving-quit-rates-of-web-delivered-interventions-for-smoking-cessation-full-scale-randomized-trial-of-webquit-org-versus-smokefree-gov
#20
Jonathan B Bricker, Kristin E Mull, Jennifer B McClure, Noreen L Watson, Jaimee L Heffner
BACKGROUND AND AIMS: Millions of people worldwide use websites to help them quit smoking, but effectiveness trials have an average 34% follow-up data retention rate and an average 9% quit rate. We compared the quit rates of a website using a new behavioral approach called Acceptance and Commitment Therapy (ACT; WebQuit.org) with the current standard of the National Cancer Institute's (NCI) Smokefree.gov website. DESIGN: A two-arm stratified double-blind individually randomized trial (n = 1319 for WebQuit; n = 1318 for Smokefree...
December 13, 2017: Addiction
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