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JOURNAL ARTICLE
Hui Ding, Minyao Xie, Jinyi Wang, Mengyuan Ouyang, Yanyuan Huang, Fangzheng Yuan, Yunhan Jia, Xuedi Zhang, Na Liu, Ning Zhang
BACKGROUND: Individuals with psychiatric disorders have elevated rates of type 2 diabetes comorbidity. Although little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetics and causal link between different type 2 diabetes and psychiatric disorders. METHODS: We conducted a large-scale genome-wide cross-trait association study(GWAS) to investigate genetic overlap between type 2 diabetes and anorexia nervosa, attention deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, schizophrenia, anxiety disorders and Tourette syndrome...
March 2023: Journal of Psychiatric Research
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JOURNAL ARTICLE
Emily J Ricketts, Sara Beth Wolicki, Joseph R Holbrook, Michelle Rozenman, Joseph F McGuire, Sana N Charania, John Piacentini, Jonathan W Mink, John T Walkup, Douglas W Woods, Angelika H Claussen
BACKGROUND: Sleep problems are common in children with Tourette Syndrome (TS). However, research regarding their demographic and clinical profile is limited. METHODS: We examined characteristics of 114 children aged five to 17 years with a lifetime diagnosis of TS and compared children with sleep disorder (n = 32) and without sleep disorder (n = 82). Parent report from the 2014 National Survey of the Diagnosis and Treatment of ADHD and Tourette Syndrome provided demographics and clinical information, other diagnosed disorders, medication use, TS severity, and impairment...
December 24, 2022: Pediatric Neurology
#23
JOURNAL ARTICLE
Luis C Farhat, Emily Behling, Angeli Landeros-Weisenberger, Jessica L S Levine, Pedro Macul Ferreira de Barros, Ziyu Wang, Michael H Bloch
BACKGROUND: In clinical practice guidelines there is no consensus about the medications that should be initially offered to children and young people with Tourette's syndrome. To provide a rigorous evidence base that could help guide decision making and guideline development, we aimed to compare the efficacy, tolerability, and acceptability of pharmacological interventions for Tourette's syndrome. METHODS: For this systematic review and network meta-analysis, we searched the Cochrane Central Register of Controlled Trials, Embase, PsycINFO, PubMed, Web of Science, the WHO International Clinical Trials Registry Platform, and ClinicalTrials...
February 2023: Lancet Child & Adolescent Health
#24
REVIEW
Samuele Cortese, Frank Mc Besag, Bruce Clark, Chris Hollis, Joseph Kilgariff, Carmen Moreno, Dasha Nicholls, Paul Wilkinson, Marc Woodbury-Smith, Aditya Sharma
The British Association for Psychopharmacology course on child and adolescent psychopharmacology has been run for more than 20 years and is currently a very popular course, attracting around 140 delegates/year from across the United Kingdom and abroad. As Faculty of recent sessions of the course, we have selected the most common questions we have been asked in recent years and provided evidence-based and/or expert-informed answers. We have included 27 questions and answers related to attention-deficit/hyperactivity disorder, anxiety and depressive disorders, autism spectrum disorder, bipolar disorder, eating disorders, epilepsy (in differential diagnosis or comorbid with mental health conditions), obsessive-compulsive disorder, personality disorders, psychotic spectrum disorders, and tics/Tourette syndrome in children and young people...
February 2023: Journal of Psychopharmacology
#25
JOURNAL ARTICLE
Paul Youssef
Most movement disorders in children are hyperkinetic. The most common type is tic disorders, which can involve motor and phonic tics and are classified as simple or complex. Motor or phonic tics that persist for more than 1 year are defined as persistent (chronic) tic disorder. Tourette syndrome can be diagnosed if a child has multiple motor tics and at least one phonic tic for more than 1 year with onset before age 18 years. Children with Tourette syndrome may have symptoms of attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, depression, or behavioral disorders...
December 2022: FP Essentials
#26
REVIEW
Addressing co-occurring conditions in behavioural therapy for tic disorders: a review and guideline.
Charlotte Sanderson, Cara Verdellen, Nanette Debes, Zsanett Tárnok, Jolande van de Griendt, Sharon Zimmerman-Brenner, Tara Murphy
Co-occurring psychiatric conditions are very common in tic disorders and Tourette syndrome. These additional symptoms are often detrimental to quality of life and may impact upon the implementation and efficacy of evidence-based behavioural therapies (BT) for tics. Combining a review of the available literature, relevant theory, and expert clinical practice, we present a guideline for implementing behavioural and psychosocial interventions when common comorbidities are present. These include attention-deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, disruptive behaviour, autism spectrum disorder (ASD) and depression...
October 25, 2022: European Child & Adolescent Psychiatry
#27
JOURNAL ARTICLE
Mathew Hakimi, Sandra Skinner, Carine W Maurer
OBJECTIVE: To clarify patterns of comorbid atopic disorders in children with tic disorders compared to controls, and to evaluate whether medications commonly used for treatment of tics and attention deficit hyperactivity disorder (ADHD) are associated with differing risks of atopy. BACKGROUND: Inflammatory mechanisms are increasingly recognized as playing a role in a range of neuropsychiatric disorders. The association between tic disorders, ADHD, obsessive-compulsive disorder (OCD) and atopic disorders is uncertain...
October 2022: Movement Disorders Clinical Practice
#28
JOURNAL ARTICLE
Na Ri Kang, Hui-Jeong Kim, Duk Soo Moon, Young Sook Kwack
Objectives: Comprehensive behavioral intervention for tics (CBIT) is effective in children with chronic tic disorders. This study aimed to assess the effect of group-based CBIT (group-CBIT) on tic severity and comorbid symptoms. We compared the efficacy of group CBIT with that of a control. Methods: Thirty children with chronic tic disorder or Tourette's disorder were enrolled in this study. Eighteen were assigned to the group-CBIT for eight sessions, and 12 were assigned to the control group...
October 1, 2022: Soa--chʻŏngsonyŏn chŏngsin ŭihak, Journal of child & adolescent psychiatry
#29
REVIEW
Anshuta Ramteke, Yashwant Lamture
Tourette syndrome (TS) is a condition characterized by tics produced because of neuropsychiatric malfunctioning occurring in childhood, which becomes less severe in adulthood, followed by a difference in the severity of tics between two persons. TS is a diverse variable in which symptoms vary in different patients. It is associated with comorbidities like obsessive-compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), and depression, and hampers the quality of life. Comorbid disorders must be investigated and treated as part of the clinical approach for all TS patients...
August 2022: Curēus
#30
JOURNAL ARTICLE
Hui Ding, Mengyuan Ouyang, Jinyi Wang, Minyao Xie, Yanyuan Huang, Fangzheng Yuan, Yunhan Jia, Xuedi Zhang, Na Liu, Ning Zhang
AIMS: Epidemiological studies demonstrate an association between classes of obesity and psychiatric disorders, although little is known about shared genetics and causality of association. Thus, we aimed to investigate shared genetics and causal link between different classes of obesity and psychiatric disorders. METHODS: We used genome-wide association study (GWAS) summary data range from 9725 to 500,199 sample sizes of European descent, conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between the classes of obesity and anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, obsessive-compulsive disorder, schizophrenia, anxiety disorders and Tourette syndrome...
September 6, 2022: Journal of Psychosomatic Research
#31
JOURNAL ARTICLE
Peristera Paschou, Yin Jin, Kirsten Müller-Vahl, Harald E Möller, Renata Rizzo, Pieter J Hoekstra, Veit Roessner, Nanette Mol Debes, Yulia Worbe, Andreas Hartmann, Pablo Mir, Danielle Cath, Irene Neuner, Heike Eichele, Chencheng Zhang, Katarzyna Lewandowska, Alexander Munchau, Julius Verrel, Richard Musil, Tim J Silk, Colleen A Hanlon, Emily D Bihun, Valerie Brandt, Andrea Dietrich, Natalie Forde, Christos Ganos, Deanna J Greene, Chunguang Chu, Michel J Grothe, Tamara Hershey, Piotr Janik, Jonathan M Koller, Juan Francisco Martin-Rodriguez, Karsten Müller, Stefano Palmucci, Adriana Prato, Shukti Ramkiran, Federica Saia, Natalia Szejko, Renzo Torrecuso, Zeynep Tumer, Anne Uhlmann, Tanja Veselinovic, Tomasz Wolańczyk, Jade-Jocelyne Zouki, Pritesh Jain, Apostolia Topaloudi, Mary Kaka, Zhiyu Yang, Petros Drineas, Sophia I Thomopoulos, Tonya White, Dick J Veltman, Lianne Schmaal, Dan J Stein, Jan Buitelaar, Barbara Franke, Odile van den Heuvel, Neda Jahanshad, Paul M Thompson, Kevin J Black
Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns...
2022: Frontiers in Psychiatry
#32
JOURNAL ARTICLE
Ying Li, Jun-Juan Yan, Yong-Hua Cui
BACKGROUND: Tourette syndrome (TS) is a complex neurodevelopmental condition marked by tics, as well as a variety of psychiatric comorbidities, such as obsessive-compulsive disorders (OCDs), attention deficit hyperactivity disorder (ADHD), anxiety, and self-injurious behavior. TS might progress to treatment-refractory Tourette syndrome (TRTS) in some patients. However, there is no confirmed evidence in pediatric patients with TRTS. AIM: To investigate the clinical characteristics of TRTS in a Chinese pediatric sample...
July 19, 2022: World Journal of Psychiatry
#33
REVIEW
Anca Maria Bejenaru, Narpinder Kaur Malhi
OBJECTIVE: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive diagnostic and therapeutic technique that has showed benefits in various psychiatric disorders. Although there is a large body of literature available on its use in adult populations, existing research in pediatric populations is very limited. Current research has primarily focused on its use in adolescent treatment-resistant depression. However, recently, rTMS has gained attention among researchers to find its utility in other neuropsychiatric disorders, such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), tics, and psychosis...
2022: Innovations in Clinical Neuroscience
#34
JOURNAL ARTICLE
Joanna Martin, Matthew Wray, Sharifah Shameem Agha, Katie J S Lewis, Richard J L Anney, Michael C O'Donovan, Anita Thapar, Kate Langley
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is highly heritable, but little is known about the relative effects of transmitted (i.e., direct) and nontransmitted (i.e., indirect) common variant risks. Using parent-offspring trios, we tested whether polygenic liability for neurodevelopmental and psychiatric disorders and lower cognitive ability is overtransmitted to ADHD probands. We also tested for indirect or genetic nurture effects by examining whether nontransmitted ADHD polygenic liability is elevated...
June 14, 2022: Biological Psychiatry
#35
JOURNAL ARTICLE
Andrea E Cavanna
INTRODUCTION: Tourette syndrome (TS) is a chronic tic disorder characterized by both motor and vocal tics. The vast majority of patients present with co-morbid behavioral problems, especially tic-related obsessive-compulsive behaviors and attention-deficit and hyperactivity disorder. Evidence-based guidelines on the pharmacotherapy of TS have become available in recent years. AREAS COVERED: The main purpose of this paper is to provide an overview of the current and emerging pharmacotherapeutic strategies for TS...
August 1, 2022: Expert Opinion on Pharmacotherapy
#36
JOURNAL ARTICLE
Cyril Atkinson-Clement, Mael Lebreton, Leïla Patsalides, Astrid de Liege, Yanica Klein, Emmanuel Roze, Emmanuelle Deniau, Andreas Hartmann, Stefano Palminteri, Yulia Worbe
BACKGROUND: Tourette syndrome (TS) as well as its most common comorbidities are associated with a higher propensity for risky behaviour in everyday life. However, it is unclear whether this increased risk propensity in real-life contexts translates into a generally increased attitude towards risk. We aimed to assess decision-making under risk and ambiguity based on prospect theory by considering the effects of comorbidities and medication. METHODS: Fifty-four individuals with TS and 32 healthy controls performed risk and ambiguity decision-making tasks under both gains and losses conditions...
July 28, 2022: Psychological Medicine
#37
JOURNAL ARTICLE
Yilong Wang, Xuebin Xu, Haihua Chen, Mengying Zhu, Xiaotong Guo, Feng Gao
Tic disorders (TDs) are a series of childhood neuropsychiatric disorders characterized by involuntary motor and/or vocal tics and commonly comorbid with several other psychopathological and/or behavioral disorders (e.g., attention deficit hyperactivity disorder and obsessive-compulsive disorder), which indeed aggravate clinical symptoms and complicate diagnosis and treatment. Micro-RNAs (miRNAs) derived from small extracellular vesicles (sEVs) have been recognized as novel circulating biomarkers of disease...
June 26, 2022: Brain Sciences
#38
JOURNAL ARTICLE
Lulin Dai, Wenying Xu, Yunhai Song, Peng Huang, Ningfei Li, Barbara Hollunder, Andreas Horn, Yiwen Wu, Chencheng Zhang, Bomin Sun, Dianyou Li
BACKGROUND: Deep brain stimulation (DBS) is a promising novel approach for managing refractory Gilles de la Tourette's syndrome (GTS). The subthalamic nucleus (STN) is the most common DBS target for treating movement disorders, and smaller case studies have reported the efficacy of bilateral STN-DBS treatment for relieving tic symptoms. However, management of GTS and treatment mechanism of STN-DBS in GTS remain to be elucidated. METHODS: Ten patients undergoing STN-DBS were included...
July 21, 2022: Journal of Neurology
#39
REVIEW
Alexey A Tomskiy, Anna A Poddubskaya, Anna A Gamaleya, Oleg S Zaitsev
Tourette syndrome (TS) is a heterogeneous disorder, which clinical presentation includes both multiple motor and vocal tics and commonly associated psychiatric conditions (obsessive-compulsive disorder, attention deficit hyperactivity disorder, depression, anxiety, etc.). Treatment options primarily consist of non-pharmacological interventions (habit reversal training, relaxation techniques, cognitive behavioral therapy, and social rehabilitation) and pharmacotherapy. In case of the intractable forms, neurosurgical treatment may be considered, primarily deep brain stimulation (DBS)...
2022: Progress in Brain Research
#40
REVIEW
Sue Woolfenden, Michelle A Farrar, Valsamma Eapen, Anne Masi, Claire E Wakefield, Nadia Badawi, Iona Novak, Natasha Nassar, Raghu Lingam, Russell C Dale
Precision medicine refers to treatments that are targeted to an individual's unique characteristics. Precision medicine for neurodevelopmental disorders (such as cerebral palsy, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, Tourette syndrome, and autism spectrum disorder) in children has predominantly focused on advances in genomic sequencing technologies to increase our ability to identify single gene mutations, diagnose a multitude of rare neurodevelopmental disorders, and gain insights into pathogenesis...
June 6, 2022: Developmental Medicine and Child Neurology
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