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https://www.readbyqxmd.com/read/29332344/in-vitro-antitumor-activity-of-guttiferone-a-in-human-breast-cancer-cells-is-mediated-via-apoptosis-mitochondrial-mediated-oxidative-stress-and-reactive-oxygen-species-production
#1
Hai-Ming Wu, Yu-Mei Li
PURPOSE: Breast cancer is the second most frequently diagnosed cancer and is considered as the main cause of cancer related death in females. It is estimated that about one-third of women with breast cancer develop metastases and eventually die of this disease. The main treatment options for breast cancer include surgical interventions followed by chemotherapy, hormonotherapy or radiation. However, the side effects associated with the treatment of breast cancer negatively affects the quality of patient's life...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332300/long-term-exposure-to-cell-phone-frequencies-900-and-1800%C3%A2-mhz-induces-apoptosis-mitochondrial-oxidative-stress-and-trpv1-channel-activation-in-the-hippocampus-and-dorsal-root-ganglion-of-rats
#2
Kemal Ertilav, Fuat Uslusoy, Serdar Ataizi, Mustafa Nazıroğlu
Mobile phone providers use electromagnetic radiation (EMR) with frequencies ranging from 900 to 1800 MHz. The increasing use of mobile phones has been accompanied by several potentially pathological consequences, such as neurological diseases related to hippocampal (HIPPON) and dorsal root ganglion neuron (DRGN). The TRPV1 channel is activated different stimuli, including CapN, high temperature and oxidative stress. We investigated the contribution TRPV1 to mitochondrial oxidative stress and apoptosis in HIPPON and DRGN following long term exposure to 900 and 1800 MHz in a rat model...
January 13, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29331575/validation-of-mri-to-trus-registration-for-high-dose-rate-prostate-brachytherapy
#3
Eric Poulin, Karim Boudam, Csaba Pinter, Samuel Kadoury, Andras Lasso, Gabor Fichtinger, Cynthia Ménard
PURPOSE: The objective of this study was to develop and validate an open-source module for MRI to transrectal ultrasound (TRUS) registration to support tumor-targeted prostate brachytherapy. METHODS AND MATERIALS: In this study, 15 patients with prostate cancer lesions visible on multiparametric MRI were selected for the validation. T2-weighted images with 1-mm isotropic voxel size and diffusion weighted images were acquired on a 1.5T Siemens imager. Three-dimensional (3D) TRUS images with 0...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29330481/fdxr-is-a-biomarker-of-radiation-exposure-in-vivo
#4
Gráinne O'Brien, Lourdes Cruz-Garcia, Matthäus Majewski, Jakub Grepl, Michael Abend, Matthias Port, Aleš Tichý, Igor Sirak, Andrea Malkova, Ellen Donovan, Lone Gothard, Sue Boyle, Navita Somaiah, Elizabeth Ainsbury, Lucyna Ponge, Krzysztof Slosarek, Leszek Miszczyk, Piotr Widlak, Edward Green, Neel Patel, Mahesh Kudari, Fergus Gleeson, Volodymyr Vinnikov, Viktor Starenkiy, Sergii Artiukh, Leonid Vasyliev, Azfar Zaman, Christophe Badie
Previous investigations in gene expression changes in blood after radiation exposure have highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional changes in blood were investigated in humans undergoing a range of external radiation exposure procedures covering several orders of magnitude (cardiac fluoroscopy, diagnostic computed tomography (CT)) and treatments (total body and local radiotherapy). Moreover, a method was developed to assess the dose to the blood using physical exposure parameters...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329998/common-error-pathways-seen-in-the-ro-ils-data-that-demonstrate-opportunities-for-improving-treatment-safety
#5
Gary Ezzell, Bhisham Chera, Adam Dicker, Eric Ford, Louis Potters, Lakshmi Santanam, Sheri Weintraub
PURPOSE: The Radiation Oncology Incident Learning System (RO-ILS) receives event reports from facilities across the country. This effort extracted common error pathways seen in the data. These pathways, expressed as fault trees, demonstrate the need for, and opportunities for, preventing these errors and/or limiting their propagation to treatment. METHODS AND MATERIALS: As of the third quarter of 2016, 2344 event reports had been submitted to RO-ILS and reviewed...
January 9, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29329996/to-prep-or-not-to-prep-that-is-the-question-a-randomized-trial-on-the-use-of-antiflatulent-medication-as-part-of-bowel-preparation-for-patients-having-image-guided-external-beam-radiation-therapy-to-the-prostate
#6
Merrylee McGuffin, Naila Devji, Lyann Kehoe, Anne Carty, Steve Russell, Lisa Di Prospero, Carlo DeAngelis, Alex Kiss, Danny Vesprini, Andrew Loblaw, Laura D'Alimonte
INTRODUCTION: Radiation therapy is a standard treatment option for prostate cancer. With growing use of escalated doses and tighter margins, procedures to limit rectal size variation are needed to reduce prostate motion, increase treatment accuracy, and minimize rectal toxicity. This prospective study was done to determine whether the introduction of an antiflatulent medication would decrease rectal distention at computed tomography (CT) simulation and throughout a course of radiation therapy...
November 4, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29329308/modeling-the-effect-of-boost-timing-in-murine-irradiated-sporozoite-prime-boost-vaccines
#7
Cristina Fernandez-Arias, Clemente F Arias, Min Zhang, Miguel A Herrero, Francisco J Acosta, Moriya Tsuji
Vaccination with radiation-attenuated sporozoites has been shown to induce CD8+ T cell-mediated protection against pre-erythrocytic stages of malaria. Empirical evidence suggests that successive inoculations often improve the efficacy of this type of vaccines. An initial dose (prime) triggers a specific cellular response, and subsequent inoculations (boost) amplify this response to create a robust CD8+ T cell memory. In this work we propose a model to analyze the effect of T cell dynamics on the performance of prime-boost vaccines...
2018: PloS One
https://www.readbyqxmd.com/read/29329263/effect-of-radiological-countermeasures-on-subjective-well-being-and-radiation-anxiety-after-the-2011-disaster-the-fukushima-health-management-survey
#8
Michio Murakami, Yoshitake Takebayashi, Yoshihito Takeda, Akiko Sato, Yasumasa Igarashi, Kazumi Sano, Tetsuo Yasutaka, Wataru Naito, Sumire Hirota, Aya Goto, Tetsuya Ohira, Seiji Yasumura, Koichi Tanigawa
After the Fukushima Daiichi Nuclear Power Station accident in 2011, concerns about radiation exposure and decline in subjective well-being have been reported. To tackle these problems, various countermeasures in relation to radiation have been implemented. In this study, we comprehensively evaluated the effects of radiological countermeasures on subjective well-being (e.g., satisfaction with life (SWL) and emotional well-being) and radiation anxiety, through a questionnaire survey targeting Fukushima residents (N = 1023)...
January 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29328046/spatiotemporal-radiotherapy-planning-using-a-global-optimization-approach
#9
Ali Adibi, Ehsan Salari
This paper aims at quantifying the extent of potential therapeutic gain, measured using biologically effective dose (BED), that can be achieved by altering the radiation dose distribution over treatment sessions in fractionated radiotherapy. To that end, a spatiotemporally integrated planning approach is developed, where the spatial and temporal dose modulations are optimized simultaneously. The concept of equivalent uniform BED (EUBED) is used to quantify and compare the clinical quality of spatiotemporally heterogeneous dose distributions in target and critical structures...
January 12, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29327290/the-diagnostic-performance-of-reduced-dose-ct-for-suspected-appendicitis-in-paediatric-and-adult-patients-a-systematic-review-and-diagnostic-meta-analysis
#10
Hee Mang Yoon, Chong Hyun Suh, Young Ah Cho, Jeong Rye Kim, Jin Seong Lee, Ah Young Jung, Jung Heon Kim, Jeong-Yong Lee, So Yeon Kim
OBJECTIVE: To evaluate the diagnostic performance of reduced-dose CT for suspected appendicitis. METHODS: A systematic search of the MEDLINE and EMBASE databases was carried out through to 10 January 2017. Studies evaluating the diagnostic performance of reduced-dose CT for suspected appendicitis in paediatric and adult patients were selected. Pooled summary estimates of sensitivity and specificity were calculated using hierarchical logistic regression modelling...
January 11, 2018: European Radiology
https://www.readbyqxmd.com/read/29327260/lifetime-study-in-mice-after-acute-low-dose-ionizing-radiation-a-multifactorial-study-with-special-focus-on-cataract-risk
#11
Claudia Dalke, Frauke Neff, Savneet Kaur Bains, Scott Bright, Deborah Lord, Peter Reitmeir, Ute Rößler, Daniel Samaga, Kristian Unger, Herbert Braselmann, Florian Wagner, Matthias Greiter, Maria Gomolka, Sabine Hornhardt, Sarah Kunze, Stefan J Kempf, Lillian Garrett, Sabine M Hölter, Wolfgang Wurst, Michael Rosemann, Omid Azimzadeh, Soile Tapio, Michaela Aubele, Fabian Theis, Christoph Hoeschen, Predrag Slijepcevic, Munira Kadhim, Michael Atkinson, Horst Zitzelsberger, Ulrike Kulka, Jochen Graw
Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate...
January 11, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29327076/arms-down-cone-beam-ct-hepatic-angiography-performance-assessment-vascular-imaging-quality-and-imaging-artifacts
#12
Adrian J Gonzalez-Aguirre, Elena N Petre, Meier Hsu, Chaya S Moskowitz, Stephen B Solomon, Jeremy C Durack
INTRODUCTION: The practice of positioning patients' arms above the head during catheter-injected hepatic arterial phase cone beam CT (A-CBCT) imaging has been inherited from standard CT imaging due to image quality concerns, but interrupts workflow and extends procedure time. We sought to assess A-CBCT image quality and artifacts with arms extended above the head versus down by the side. METHODS: We performed an IRB approved retrospective evaluation of reformatted and 3D-volume rendered images from 91 consecutive A-CBCTs (43 arms up, 48 arms down) acquired during hepatic tumor arterial embolization procedures...
January 11, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29326533/manually-steerable-catheter-with-improved-agility
#13
Geir Arne Tangen, Frode Manstad-Hulaas, Erik Nypan, Reidar Brekken
Purpose: A prototype steerable catheter was designed for endovascular procedures. This technical pilot study reports the initial experience using the catheter for cannulation of visceral arteries. Technique: The 7F catheter was manually steerable with operator control handle for bending and rotation of the tip. The maximum bending angle was approximately 90° and full 360° rotation of the tip was supported. The study involved 1 pig with 4 designated target arteries: the left and right renal arteries, the superior mesenteric artery, and the celiac trunk...
2018: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/29326136/using-correlative-properties-of-neighboring-pixels-to-improve-gray-white-differentiation-in-pediatric-head-ct-images
#14
T P Madaelil, A Sharma, C Hildebolt, M Parsons
BACKGROUND AND PURPOSE: A lower radiation dose can have a detrimental effect on the quality of head CT images. The aim of this study performed in a pediatric population was to test whether an image-processing algorithm (Correlative Image Enhancement) based on the correlation among intensities of neighboring pixels can improve gray-white differentiation in head CTs. MATERIALS AND METHODS: Sixty baseline head CT images with normal findings obtained from scans of 30 children were processed using Correlative Image Enhancement to produce corresponding enhanced images...
January 11, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29325801/editorial-the-role-of-medical-physics-in-lung-sbrt
#15
EDITORIAL
Pietro Mancosu, Andrew Nisbet, Núria Jornet
Stereotactic body radiation therapy (SBRT) has become a standard treatment for non-operable patients with early stage non-small cell lung cancer (NSCLC). In this context, medical physics community has largely helped in the starting and the growth of this technique. In fact, SBRT requires the convergence of many different features for delivering large doses in few fractions to small moving target in an heterogeneous medium. The special issue of last month, was focused on the different physics challenges in lung SBRT...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29325596/late-normal-tissue-response-in-the-rat-spinal-cord-after-carbon-ion-irradiation
#16
Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus, Christian P Karger
BACKGROUND: The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the "clinical research group ion beam therapy" funded by the German Research Foundation (DFG, KFO 214). METHODS AND MATERIALS: Dose-response curves for the endpoint radiation-induced myelopathy were determined at 6 different positions (LET 16-99 keV/μm) within a 6 cm spread-out Bragg peak using either 1, 2 or 6 fractions of carbon ions...
January 11, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29325319/-application-of-half-dose-spectral-ct-based-on-the-automatic-spectral-imaging-mode-selection-and-adaptive-statistical-iterative-reconstruction-in-the-ct-examination-of-upper-abdomen-in-obese-patients
#17
H P Zhao, P J Lü, L Y Zhang, W R Li, P Hou, J B Gao
Objective: To investigate the value of combined use of half-dose spectral CT based on the automatic spectral imaging mode selection (GSI Assist) and adaptive statistical iterative reconstruction (ASIR) in the CT examination of upper abdomen in obese patients as compared with conventional CT. Methods: Eight-two obese patients (body mass index≥29 kg/m(2)) were prospectively selected from October to December 2016, and contrast-enhanced CT during arterial phase (AP) and portal venous phase (PVP) were carried out in those patients...
December 19, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29324933/brachytherapy-in-soft-tissue-tumours-an-interdisciplinary-challenge
#18
Silvanie Volz, Konstantinos Kalousis, Jung In Song, Tobias Kisch, Eike Wenzel, Peter Mailänder
OBJECTIVE: Interdisciplinary work including surgery and additive radiotherapy is often needed for the therapy of tumours. Beneath this, brachytherapy is an important part of the radiotherapy. It was first used over 100 years ago and is in regular use after the development of afterload technology in the early 1970s. Today it is often used in different tumour therapies, for example in soft tissue sarcoma or breast tumours, in order to decrease the risk of local recurrence. Concerning its benefits, higher doses could be used because of the localized effect with equivalent local control rate and less toxicity of treatment...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324721/electromagnetic-acoustic-transducers-for-robotic-nondestructive-inspection-in-harsh-environments
#19
Sungho Choi, Hwanjeong Cho, Matthew S Lindsey, Cliff J Lissenden
Elevated temperature, gamma radiation, and geometric constraints inside dry storage casks for spent nuclear fuel represent a harsh environment for nondestructive inspection of the cask and require that the inspection be conducted with a robotic system. Electromagnetic acoustic transducers (EMATs) using non-contact ultrasonic transduction based on the Lorentz force to excite/receive ultrasonic waves are suited for use in the robotic inspection. Periodic permanent magnet EMATs that actuate/receive shear horizontal guided waves are developed for application to robotic nondestructive inspection of stress corrosion cracks in the heat affected zone of welds in stainless steel dry storage canisters...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29324439/hybrid-dose-calculation-a-dose-calculation-algorithm-for-microbeam-radiation-therapy
#20
Mattia Donzelli, Elke Brauer-Krisch, Uwe Oelfke, Jan J Wilkens, Stefan Bartzsch
Microbeam Radiation Therapy (MRT) is a still preclinical approach in radiation oncology that uses planar micrometre wide beamlets with extremely high peak doses, separated by a few hundred micrometre wide low dose regions. Abundant preclinical evidence demonstrates that MRT spares normal tissue more effectively than conventional radiation therapy, at equivalent tumour control. In order to launch first clinical trials, accurate and efficient dose calculation methods are an inevitable prerequisite. In this work a hybrid dose calculation approach is presented which is based on a combination of Monte Carlo and kernel based dose calculation...
January 11, 2018: Physics in Medicine and Biology
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