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https://www.readbyqxmd.com/read/28931214/baicalin-alleviates-radiation-induced-epithelial-mesenchymal-transition-of-primary-type-ii-alveolar-epithelial-cells-via-tgf-%C3%AE-and-erk-gsk3%C3%AE-signaling-pathways
#1
Jinhua Lu, Yazhen Zhong, Zechen Lin, Xianlei Lin, Zhaohui Chen, Xuping Wu, Nan Wang, Haiqiao Zhang, Siyu Huang, Yuan Zhu, Yuanyuan Wang, Shengyou Lin
BACKGROUND: Radiation therapy is commonly used to treat thoracic malignancies. However, it may lead to severe lung pneumonitis and ultimately fibrosis. Irradiation has been reported to increase epithelial-mesenchymal transition (EMT) of type II alveolar epithelial cells (AEC), which play an important role in pulmonary fibrosis. The transforming growth factor-β (TGF-β) and ERK/glycogen synthase kinase 3β (GSK3β) pathways are critically involved in radiation-induced EMT. In the present study, we investigated whether baicalin was a novel therapeutic candidate for radiation-induced EMT in type II AEC...
September 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28931106/a-case-of-prethoracic-pain-radiating-upward-and-initiating-nervus-intermedius-neuralgia-and-migraine-headache-could-epicrania-fugax-pain-start-in-the-upper-body
#2
Yu Wang, Pei-Lin Kan, Yuan-Feng Tao, Xiao-Yan Li, Xiao-Juan Yang, Gui-Ling Liang
Epicrania fugax (EF) was recently classified as a primary headache in the Appendix of the International Classification of Headache Disorders, third edition (ICHD-III). It is characterized by a paroxysmal pain rapidly radiating forward or backward along a linear or zigzag trajectory on the surface of the head. This article reports a 76-year-old woman who newly developed a paroxysmal EF-type pain distributed not only in the territories of the trigeminal and occipital nerves, but also in the territories of the cervical and thoracic nerves...
September 20, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28931006/up-regulation-of-calreticulin-in-mouse-liver-tissues-after-long-term-irradiation-with-low-dose-rate-gamma-rays
#3
Lan Yi, Nan Hu, Jie Yin, Jing Sun, Hongxiang Mu, Keren Dai, Dexin Ding
The biological effects of low-dose or low-dose-rate ionizing radiation on normal tissues has attracted attention. Based on previous research, we observed the morphology of liver tissues of C57BL/6J mice that received <50, 50-500, and 500-1000 μGy/h of 137Cs radiation for 180 d. We found that the pathological changes in liver tissues were more obvious as the irradiation dose rates increased. Additionally, differential protein expression in liver tissues was analyzed using a proteomics approach. Compared with the matched group in the 2D gel analysis of the irradiated groups, 69 proteins had ≥ 1...
2017: PloS One
https://www.readbyqxmd.com/read/28930778/radioprotection-with-amifostine-enhances-bone-strength-and-regeneration-and-bony-union-in-a-rat-model-of-mandibular-distraction-osteogenesis
#4
Catherine N Tchanque-Fossuo, Alexis Donneys, Sagar S Deshpande, Deniz Sarhaddi, Noah S Nelson, Laura A Monson, Sara E Dahle, Steve A Goldstein, Steven R Buchman
BACKGROUND: Using distraction osteogenesis (DO) to regenerate robust endogenous bone could greatly enhance postoncologic reconstruction of head and neck cancer. However, radiation (XRT) corrosive effects still preclude DO's immense potential. We posit that adjunctive pretreatment with the radioprotectant amifostine (AMF) can optimize wound healing and allow for successful DO with quantifiable enhancements in bony union and strength despite previous surgical bed irradiation. METHODS: Two groups of murine left hemimandibles were exposed to a human equivalent radiation dosage fractionated over 5 daily doses of 7 Gy...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28930297/estimated-radiation-exposure-of-german-commercial-airline-cabin-crew-in-the-years-1960-2003-modeled-using-dose-registry-data-for-2004-2015
#5
Daniel Wollschläger, Gaël Paul Hammer, Thomas Schafft, Steffen Dreger, Maria Blettner, Hajo Zeeb
Exposure to ionizing radiation of cosmic origin is an occupational risk factor in commercial aircrew. In a historic cohort of 26,774 German aircrew, radiation exposure was previously estimated only for cockpit crew using a job-exposure matrix (JEM). Here, a new method for retrospectively estimating cabin crew dose is developed. The German Federal Radiation Registry (SSR) documents individual monthly effective doses for all aircrew. SSR-provided doses on 12,941 aircrew from 2004 to 2015 were used to model cabin crew dose as a function of age, sex, job category, solar activity, and male pilots' dose; the mean annual effective dose was 2...
September 20, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28930093/a-reusable-osl-film-for-2d-radiotherapy-dosimetry
#6
Wouter Crijns, Dirk Adelin Vandenbroucke, Paul Leblans, Tom Depuydt
Purpose Optical stimulated luminescence (OSL) combines reusability, sub-mm resolution, and a linear dose response in a single radiation detection technology. Such a combination is currently lacking in radiotherapy dosimetry. But OSL-films have a strong energy dependent response to keV photons due to a relative high effective atomic number (Zeff). The current work studied the applicability of a 2D OSL-film with a reduced Zeff as (IMRT/VMAT) dosimeter. Methods and Materials Based on their commercial OSL-film experience, Agfa Healthcare N...
September 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28929329/somatic-health-effects-of-chernobyl-30-years-on
#7
REVIEW
Maureen Hatch, Elisabeth Cardis
2016 marked the 30th anniversary of the Chernobyl Nuclear Power Plant accident. We and others wrote reviews for the 25th anniversary. Since then, additional papers have appeared and it seems timely to highlight lessons learned. To present, not a systematic review, but a commentary drawing attention to notable findings. We include not only recent reports and updates on previous results, but key findings from prior Chernobyl studies. The dose-dependent increase in Papillary Thyroid Cancer (PTC) following childhood I-131 exposure in Ukraine and Belarus has now been shown to persist for decades...
September 19, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28929083/emerging-therapies-for-stage-iii-non-small-cell-lung-cancer-stereotactic-body-radiation-therapy-and-immunotherapy
#8
REVIEW
Sameera S Kumar, Kristin A Higgins, Ronald C McGarry
The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. In unresectable NSCLC, chemoradiation has been the standard of care for the past three decades. Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. Though initial studies showed a benefit to dose escalation, phase III studies examining dose escalation using standard fractionation or hyperfractionation have failed to show a benefit...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28928914/reducing-radiation-exposure-in-an-electrophysiology-lab-with-introduction-of-newer-fluoroscopic-technology
#9
Munish Sharma, Koroush Khalighi
The use of fluoroscopic devices exposes patients and operators to harmful effects of ionizing radiation in an electrophysiology (EP) lab. We sought to know if the newer fluoroscopic technology (Allura Clarity) installed in a hybrid EP helps to reduce prescribed radiation dose. We performed radiation dose analysis of 90 patients who underwent various procedures in the EP lab at a community teaching hospital after the introduction of newer fluoroscopic technology in June of 2016. Watchman device insertion, radiofrequency ablation procedures, permanent pacemaker (PPM)/implantable cardioverter defibrillator (ICD) placement and battery changes were included in the study to compare radiation exposure during different procedures performed commonly in an EP lab...
June 7, 2017: Clinics and Practice
https://www.readbyqxmd.com/read/28928873/who-benefited-most-from-higher-cumulative-dose-of-cisplatin-among-patients-with-locally-advanced-nasopharyngeal-carcinoma-treated-by-intensity-modulated-radiation-therapy-a-retrospective-study-of-527-cases
#10
Xiaomin Ou, Tingting Xu, Xiayun He, Hongmei Ying, Chaosu Hu
PURPOSE: Our previous study demonstrated the benefit of cumulative dose of cisplatin during the whole treatment on locally advanced nasopharyngeal carcinoma (NPC) treated with various chemotherapy strategies. The purpose of this study is to identify the subgroup of locally advanced NPC who benefits from higher dose of cisplatin, and to clarify whether cumulative dose of cisplatin during the whole treatment brings survival benefit to those treated with concurrent chemoradiotherapy (CCRT)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928795/sensitivity-analysis-of-the-integral-quality-monitoring-system%C3%A2-using-monte-carlo-simulation
#11
Oluwaseyi M Oderinde, F C P du Plessis
The Integral Quality Monitoring (IQM) System is a real-time beam output verifying system that validates the integrity and accuracy of patient treatment plan (TP) data during radiation treatment. The purpose of this study was to evaluate the sensitivity of the IQM to errors in segment using EGSnrc/BEAMnrc Monte Carlo (MC) codes. Sensitivity analysis (SA) techniques were applied to study the significance of small alterations of field sizes (segments) on the IQM signal response. One hundred and eighty multileaf segments were analyzed with methods that include scatter plots (SP), brute force, variance-based (VAR), and standard regression coefficient SA...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28928609/initial-experience-with-the-3-3-fr-mongoose-%C3%A2-pigtail-catheter-for-aortic-angiography-during-patent-ductus-arteriosus-closure-in-small-patients
#12
Zachary Hena, Nicole J Sutton, Gregory J Gates, Benjamin H Taragin, Robert H Pass
BACKGROUND: Smaller femoral arterial sheaths may be associated with fewer vascular complications. The 3.3 Fr Mongoose(®) Pediavascular pigtail catheter is a catheter that allows higher flow rates, potentially resulting in improved angiographic quality. We reviewed our experience with this small catheter during patent ductus arteriosus (PDA) closure. MATERIALS AND METHODS: Review of patients ≤20 kg in whom the Mongoose(®) catheter was used during PDA closure from 12/13 to 4/15...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28927756/recent-time-trends-and-predictors-of-heart-dose-from-breast-radiation-therapy-in-a-large-quality-consortium-of-radiation-oncology-practices
#13
Lori J Pierce, Mary Feng, Kent A Griffith, Reshma Jagsi, Thomas Boike, Daniel Dryden, Gregory S Gustafson, Lisa Benedetti, Martha M Matuszak, Teamour S Nurushev, Joe Haywood, Jeffrey D Radawski, Corey Speers, Eleanor M Walker, James A Hayman, Jean M Moran
PURPOSE: Limited data exist regarding the range of heart doses received in routine practice with radiation therapy (RT) for breast cancer in the United States today and the potential effect of the continual assessment of the cardiac dose on practice patterns. METHODS AND MATERIALS: From 2012 to 2015, 4688 patients with breast cancer treated with whole breast RT at 20 sites participating in a state-wide consortium were enrolled into a registry. The importance of limiting the cardiac dose has been emphasized in the consortium since 2012, and the mean heart dose (MHD) has been reported by each institution since 2014...
July 22, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28927598/radiation-induced-crosslinking-of-polyacrylamide-incorporated-low-molecular-weights-natural-polymers-for-possible-use-in-the-agricultural-applications
#14
Ahmed M Elbarbary, Hassan A Abd El-Rehim, Naeem M El-Sawy, El-Sayed A Hegazy, El-Sayed A Soliman
Superabsorbent hydrogels based on polyacrylamide (PAAm) and Na-alginate (Alg) or chitosan (CS) were synthesized by γ-rays. The effect of dose and copolymer composition on gel content and water absorbency of PAAm/Alg, PAAm/CS and PAAm/Alg/CS hydrogels were studied. The gel content and water absorbency follows the order PAAm/Alg>PAAm/Alg/CS>PAAm/CS. The effect of different cations, fertilizers, buffers on water absorbency of the hydrogels was investigated. Water retention capability of swollen hydrogels as a function of time was studied...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28927550/assessing-dose-variance-from-immobilization-devices-in-vmat-head-and-neck-treatment-planning-a-retrospective-case-study-analysis
#15
Alyssa Olson, Kristine Phillips, Tamara Eng, Nishele Lenards, Ashley Hunzeker, Daniel Lewis, Douglas Baumann
Immobilization devices serve several purposes in radiation oncology including improved positional reproducibility and decreased patient movement. If immobilization device beam attenuation is unaccounted for in the treatment planning process, planning target volume (PTV) coverage can be compromised. A retrospective case study was performed to evaluate beam attenuation from head and neck (HN) immobilization devices in volumetric-modulated arc therapy using the Eclipse treatment planning system and the Anisotropic Analytical Algorithm...
September 15, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28927529/targeting-telomerase-and-telomeres-to-enhance-ionizing-radiation-effects-in-in-vitro-and-in-vivo-cancer-models
#16
REVIEW
F Berardinelli, E Coluzzi, A Sgura, A Antoccia
One of the hallmarks of cancer consists in the ability of tumor cells to divide indefinitely, and to maintain stable telomere lengths throughout the activation of specific telomere maintenance mechanisms (TMM). Therefore in the last fifteen years, researchers proposed to target telomerase or telomeric structure in order to block limitless replicative potential of cancer cells providing a fascinating strategy for a broad-spectrum cancer therapy. In the present review, we report in vitro and in vivo evidence regarding the use of chemical agents targeting both telomerase or telomere structure and showing promising antitumor effects when used in combination with ionizing radiation (IR)...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28927522/significance-and-nature-of-bystander-responses-induced-by-various-agents
#17
REVIEW
Neha Verma, Ashu Bhan Tiku
Bystander effects in a biological system are the responses shown by non-targeted neighbouring cells/tissues/organisms. These responses are triggered by factors released from targeted cells when exposed to a stress inducing agent. The biological response to stress inducing agents is complex, owing to the diversity of mechanisms and pathways activated in directly targeted and bystander cells. These responses are highly variable and can be either beneficial or hazardous depending on the cell lines tested, dose of agent used, experimental end points and time course selected...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28927299/evaluation-of-image-quality-and-radiation-dose-of-abdominal-dual-energy-ct
#18
David Schmidt, Marcus Söderberg, Mats Nilsson, Håkan Lindvall, Christina Christoffersen, Peter Leander
Background Dual-energy computed tomography (DECT) has conceptually been known since the late 1970s and commercially available as dual-source CT (DSCT) systems since 2006; however, the technique has not yet seen widespread implementation in routine protocols. Part of the cause for this is likely due to misconceptions about radiation dose and/or image quality when using DECT. Purpose To compare image quality and radiation dose of single-energy CT (SECT) and DECT abdominal examinations obtained in clinical practice on a second generation DSCT...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28927206/preoperative-magnetic-resonance-and-intraoperative-computed-tomography-fusion-for-real-time-neuronavigation-in-intramedullary-lesion-surgery
#19
Francesco Costa, Alessandro Ortolina, Andrea Cardia, Marco Riva, Martina Revay, Guido Pecchioli, Carla Daniela Anania, Francesco Asteggiano, Maurizio Fornari
BACKGROUND: Image-guided surgery techniques in spinal surgery are usually based upon fluoroscopy or computed tomography (CT) scan, which allow for a real-time navigation of bony structures, though not of neural structures and soft tissue remains. OBJECTIVE: To verify the effectiveness and efficacy of a novel technique of imaging merging between preoperative magnetic resonance imaging (MRI) and intraoperative CT scan during removal of intramedullary lesions. METHODS: Ten consecutive patients were treated for intramedullary lesions using a navigation system aid...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926987/the-impact-of-non-lethal-single-dose-radiation-on-tumor-invasion-and-cytoskeletal-properties
#20
Tim Hohmann, Urszula Grabiec, Carolin Vogel, Chalid Ghadban, Stephan Ensminger, Matthias Bache, Dirk Vordermark, Faramarz Dehghani
Irradiation is the standard therapy for glioblastoma multiforme. Glioblastoma are highly resistant to radiotherapy and the underlying mechanisms remain unclear. To better understand the biological effects of irradiation on glioblastoma cells, we tested whether nonlethal irradiation influences the invasiveness, cell stiffness, and actin cytoskeleton properties. Two different glioblastoma cell lines were irradiated with 2 Gy and changes in mechanical and migratory properties and alterations in the actin structure were measured...
September 18, 2017: International Journal of Molecular Sciences
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