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https://www.readbyqxmd.com/read/27792038/role-of-cannabis-in-digestive-disorders
#1
Hemant Goyal, Umesh Singla, Urvashi Gupta, Elizabeth May
Cannabis sativa, a subspecies of the Cannabis plant, contains aromatic hydrocarbon compounds called cannabinoids. [INCREMENT]-Tetrahydrocannabinol is the most abundant cannabinoid and is the main psychotropic constituent. Cannabinoids activate two types of G-protein-coupled cannabinoid receptors: cannabinoid type 1 receptor and cannabinoid type 2 receptor. There has been ongoing interest and development in research to explore the therapeutic potential of cannabis. [INCREMENT]-Tetrahydrocannabinol exerts biological functions on the gastrointestinal (GI) tract...
October 27, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27790307/primary-signet-ring-cell-carcinoma-of-the-prostate-treated-by-radical-cystoprostatectomy-and-chemoradiotherapy
#2
Sun Wook Kim, Woohyun Kim, Yong-Hyun Cho, Tae-Jung Kim, Insuk Woo, Dong Wan Sohn
Primary signet ring cell carcinoma (SRCC) of the prostate is very rare. Although SRCC is primarily found in the stomach and colon, it can also be found in the pancreas, breast, thyroid, bladder, and prostate. We recently diagnosed and treated a case of primary SRCC of the prostate. A 56-year-old Korean man was referred to our institution for evaluation of a one-month history of hematuria and recently identified bladder mass. Transurethral resection of the bladder tumour was performed and histological and immunohistochemical evaluation revealed a diagnosis of SRCC with tumour invading into the outer half of the deep muscularis propria...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27342825/the-multidisciplinary-approach-to-gi-cancer-results-in-change-of-diagnosis-and-management-of-patients-multidisciplinary-care-impacts-diagnosis-and-management-of-patients
#3
Cheryl Meguid, Richard D Schulick, Tracey E Schefter, Christopher H Lieu, Megan Boniface, Nicole Williams, Jon D Vogel, Csaba Gajdos, Martin McCarter, Barish H Edil
BACKGROUND: The multidisciplinary approach to GI cancer is becoming more widespread as a result of multimodality therapy. At the University of Colorado Hospital (UCH), we utilize a formal multidisciplinary approach through specialized clinics across a variety of settings, including pancreas and biliary cancer, esophageal and gastric cancer, liver cancer and neuroendocrine tumors (NET), and colorectal cancer. Patients with these suspected diagnoses are seen in a multidisciplinary clinic...
June 24, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27326246/genomic-profiling-of-metastatic-gastroenteropancreatic-neuroendocrine-tumor-gep-net-patients-in-the-personalized-medicine-era
#4
Seung Tae Kim, Su Jin Lee, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Jeeyun Lee, Young Suk Park
BACKGROUND: We have conducted molecular profiling through a high-throughput molecular test as part of our clinical practice for patients with advanced gastrointestinal (GI) cancer or rare cancers including gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Herein, we report on the molecular characterization of 14 metastatic GEP-NET patients. METHODS: We conducted the Ion AmpliSeq Cancer Hotspot Panel v2 (detecting 2,855 oncogenic mutations in 50 commonly mutated genes) and nCounter Copy Number Variation Assay, which was designed with 21 genes based on available targeted agents, as a high throughput genomic platform in 14 patients with metastatic GEP-NETs...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27303130/carcinoid-tumour-of-caecum-an-unusual-palpable-mass-in-the-right-iliac-fossa
#5
Mohit M Agrawal, Nandkishor S Sude
Carcinoid tumour represents 0.8-1.5 % of malignant digestive tumours. Gastrointestinal (GI) carcinoids account for 95 % of all the carcinoids, and caecal carcinoids account for 5 % of all the carcinoids. These tumours are frequent in women (2-4:1) as reported by Spallitta and Termine (Minerva Chir 55:77-87, 2002). In order of frequency, they may occur in the appendix (35 %), ileum (28 %), rectum (13 %) and bronchi. Incidence is less than 1 % in the pancreas, gall bladder, liver, larynx, testes and ovaries...
April 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/27138887/brain-gut-axis-and-pentadecapeptide-bpc-157-theoretical-and-practical-implications
#6
Sikiric Predrag, Seiwerth Sven, Rucman Rudolf, Kolenc Danijela, Batelja Vuletic Lovorka, Drmic Domagoj, Grgic Tihomir, Strbe Sanja, Zukanovic Goran, Crvenkovic Dalibor, Madzarac Goran, Rukavina Iva, Sucic Mario, Baric Marko, Starcevic Neven, Krstonijevic Zoran, Lovric Bencic Martina, Filipcic Igor, Stancic Rokotov Dinko, Vlainic Josipa
BACKGROUND: Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice. METHODS: Review of our research on BPC 157 in terms of brain-gut axis...
May 2, 2016: Current Neuropharmacology
https://www.readbyqxmd.com/read/27123107/coexisting-and-possible-primary-extra-gastrointestinal-stromal-tumors-of-the-pancreas-and-liver-a-single-case-report
#7
Lei Liu, Yingqiao Zhu, Dongxuan Wang, Changbin Yang, Q I Zhang, Xiukun Li, Yang Bai
Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms of the gastrointestinal tract (GI) that are defined, in part, by the expression of CD117, a c-Kit proto-oncogene protein. GISTs emerge outside of the GI at a very low frequency, typically in a single organ or location. GISTs that occasionally emerge outside of the GI are classified as extra-gastrointestinal stromal tumors (EGIST). The present study reports an extremely rare case of EGIST detected in the pancreas and the liver. The pancreatic and liver tumors were 4...
May 2016: Oncology Letters
https://www.readbyqxmd.com/read/27109336/brain-gut-axis-and-pentadecapeptide-bpc-157-theoretical-and-practical-implications
#8
Sikiric Predrag, Seiwerth Sven, Rucman Rudolf, Kolenc Danijela, Batelja Vuletic Lovorka, Drmic Domagoj, Grgic Tihomir, Strbe Sanja, Zukanovic Goran, Crvenkovic Dalibor, Madzarac Goran, Rukavina Iva, Sucic Mario, Baric Marko, Starcevic Neven, Krstonijevic Zoran, Lovric Bencic Martina, Filipcic Igor, Stancic Rokotov Dinko, Vlainic Josipa
BACKGROUND: Brain-gut interaction involves, among others, peptidergic growth factors which are native in GI tract and have strong antiulcer potency and thus could from periphery beneficially affect CNS-disorders. We focused on the stable gastric pentadecapeptide BPC 157, an antiulcer peptidergic agent, safe in inflammatory bowel disease trials and now in multiple sclerosis trial, native and stable in human gastric juice. METHODS: Review of our research on BPC 157 in terms of brain-gut axis...
April 25, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27070809/design-and-demonstration-of-a-pumpless-14-compartment-microphysiological-system
#9
Paula G Miller, Michael L Shuler
We describe a human "Body-on-a-chip" device (or microphysiological system) that could be used to emulate drug distribution, metabolism, and action in the body. It is based upon a physiologically based pharmacokinetic-pharmacodynamic (PBPK-PD) model, where multiple chambers representing different organs are connected with fluidic channels to mimic multi-organ interactions within the body. Here we describe a pumpless 14 chamber (13 organs) microfluidic cell culture device that provides a separation between barrier and nonbarrier types of cell cultures...
October 2016: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/26884655/an-analysis-of-the-origins-subjects-and-awards-received-for-presentations-at-the-annual-iasg-conferences-2009-2013
#10
Subhash Soni, Peush Sahni, Samiran Nundy
s presented at scientific meetings are important for making ongoing research more widely known and may also reflect the quality of the parent institution's standard of patient care. We analyzed the abstracts presented at the annual meetings of IASG for the past 5 years for (i) medium of presentation (oral/poster/videos), (ii) subjects discussed, (iii) institution of origin, (iv) whether a prospective/ retrospective study or a case report, (v) changing trends, and (vi) awards received. Of the 1340 abstracts analyzed, there were 18...
December 2015: Indian Journal of Surgery
https://www.readbyqxmd.com/read/26786687/glp-1-based-therapies-clinical-implications-for-gastroenterologists
#11
REVIEW
Mark M Smits, Daniel H van Raalte, Lennart Tonneijck, Marcel H A Muskiet, Mark H H Kramer, Djuna L Cahen
The gut-derived incretin hormone, glucagon-like peptide 1 (GLP-1) lowers postprandial blood glucose levels by stimulating insulin and inhibiting glucagon secretion. Two novel antihyperglycaemic drug classes augment these effects; GLP-1 receptor agonists and inhibitors of the GLP-1 degrading enzyme dipeptidyl peptidase 4. These so called GLP-1 based or incretin based drugs are increasingly used to treat type 2 diabetes, because of a low risk of hypoglycaemia and favourable effect on body weight, blood pressure and lipid profiles...
April 2016: Gut
https://www.readbyqxmd.com/read/26769020/right-hepatic-artery-from-splenic-artery-the-four-leaf-clover-of-hepatic-surgery
#12
Francesco Caruso, Daniele Dondossola, Gianluca Fornoni, Lucio Caccamo, Giorgio Rossi
The anatomy of hepatic arteries is one of the most variable. Accurate awareness of all the possible anatomic variations is crucial in the upper GI surgery and especially in liver and pancreas transplantation. The most frequent anatomical variants are: a replaced or accessory right hepatic artery (RHA) from the superior mesenteric artery (6.3-21 %), a replaced or accessory left hepatic artery (LHA) from the left gastric artery (LGA) (3-18 %) or a combination of these two variants (up to 7.4 %). Herein, we describe the case of a 67-year-old cadaveric organ donor who presented a RHA originating from the splenic artery (SA) associated with both a CHA originating from the celiac trunk (CT) and a LHA originating from the LGA...
September 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/26621476/nutritional-value-of-electron-beam-irradiated-cottonseed-meal-in-broiler-chickens
#13
M Nayefi, S Salari, M Sari, M Behgar
This study was conducted to evaluate the effect of electron beam-irradiated cottonseed meal on performance, carcass characteristics and some blood parameters of broiler chicks. Treatments were cottonseed meal (CSM) at levels of 12% and 24% (raw and irradiated at 30 kGy) and corn-soya bean meal diet (as control, without CSM and without irradiation) that used with five dietary treatments, four replicates and 10 birds of each for 42 days in completely randomized design. Feed intake (FI) and body weight gain (BWG) were recorded weekly...
August 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/26550047/comparison-of-diagnostic-sensitivity-and-quantitative-indices-between-68-ga-dotatoc-pet-ct-and-111-in-pentetreotide-spect-ct-in-neuroendocrine-tumors-a-preliminary-report
#14
Inki Lee, Jin Chul Paeng, Soo Jin Lee, Chan Soo Shin, Jin-Young Jang, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
PURPOSE: In-pentetreotide has been used for neuroendocrine tumors expressing somatostatin receptors. Recently, (68)Ga-DOTATOC PET has been used with the advantage of high image quality. In this study, we compared quantitative indices between (111)In-pentetreotide SPECT/CT and (68)Ga-DOTATOC PET/CT. METHODS: Thirteen patients diagnosed with neuroendocrine tumors were prospectively recruited. Patients underwent (111)In-pentetreotide scans with SPECT/CT and (68)Ga-DOTATOC PET/CT before treatment...
December 2015: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26478679/geographical-distribution-of-the-incidence-of-gastric-cancer-in-bhutan
#15
Tashi Dendup, James M Richter, Yoshio Yamaoka, Kinley Wangchuk, Hoda M Malaty
AIM: To estimate the prevalence of gastric cancer (GC) in a cohort of patients diagnosed with GC and to compare it with patients diagnosed with all other types of gastro-intestinal (GI) cancer during the same period. METHODS: Between 2008 and 2013, five-year period, the medical records of all GI cancer patients who underwent medical care and confirm diagnosis of cancer were reviewed at the National Referral Hospital, Thimphu which is the only hospital in the country where surgical and cancer diagnosis can be made...
October 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26396718/gastrointestinal-stromal-tumors-in-northeastern-iran-46-cases-during-2003-2012
#16
Masoumeh Salari, Mitra Ahadi, Seyed Mousalreza Hoseini, Elham Mokhtari, Kamran Gafarzadehgan, Hamid Reza Hashemian, Benyamin Esmaeili, Hassan Vossoughinia
BACKGROUND Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. They are usually C-kit positive and seen slightly more common in men. These tumors are seen in the GI tract from the esophagus to the anus with occasional invasion or metastasis. METHODS In this retrospective study, we evaluated the prevalence of c-kit positive stromal tumors of the GI tract based on age, site of involvement, size of tumor, local invasion, and Immunohistochemical markers...
July 2015: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/26321404/systemic-involvement-in-mycosis-fungoides
#17
REVIEW
Günter Burg
Mycosis fungoides (MF) represents almost 50% of all primary cutaneous lymphomas and more than 70% of cutaneous T-cell lymphomas (CTCL). Arising from preferentially skin-homing lymphocytes with genetic instability, MF evolves through stages (IA-IVB), producing inconspicuous inflammatory features in the beginning and finally resulting in a proliferation of cytomorphologic, phenotypic, and genotypic abnormal tumor cells. Over the past 200 years, there has been much confusion in the classification of lymphomas due to semantic disagreements (MF, CTCL, parapsoriasis, lymphosarcoma, reticulum cell sarcoma, and many other terms), lack of diagnostic standard criteria, and new molecular diagnostic methods...
September 2015: Clinics in Dermatology
https://www.readbyqxmd.com/read/26315842/intestinal-glp-1-and-satiation-from-man-to-rodents-and-back
#18
REVIEW
R E Steinert, C Beglinger, W Langhans
In response to luminal food stimuli during meals, enteroendocrine cells release gastrointestinal (GI) peptides that have long been known to control secretory and motor functions of the gut, pancreas and liver. Glucagon-like peptide-1 (GLP-1) has emerged as one of the most important GI peptides because of a combination of functions not previously ascribed to any other molecule. GLP-1 potentiates glucose-induced insulin secretion, suppresses glucagon release, slows gastric emptying and may serve as a satiation signal, although the physiological status of the latter function has not been fully established yet...
February 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/25918298/role-of-radiotherapy-and-newer-techniques-in-the-treatment-of-gi-cancers
#19
REVIEW
Carla Hajj, Karyn A Goodman
The role of radiotherapy in multidisciplinary treatment of GI malignancies is well established. Recent advances in imaging as well as radiotherapy planning and delivery techniques have made it possible to target tumors more accurately while sparing normal tissues. Intensity-modulated radiotherapy is an advanced method of delivering radiation using cutting-edge technology to manipulate beams of radiation. The role of intensity-modulated radiotherapy is growing for many GI malignancies, such as cancers of the stomach, pancreas, esophagus, liver, and anus...
June 1, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/25815994/snapshot-gi-tract-development
#20
Patrick S McGrath, James M Wells
The endoderm germ layer contributes to the respiratory and gastrointestinal (GI) lineages during development, giving rise to an array of specialized epithelial cell types lining organs, including the thyroid, thymus, lungs, liver, biliary system, pancreas, and intestines. This SnapShot timelines and summarizes key stages following gastrulation, including endoderm patterning, organ specification, and organogenesis. A lineage tree of the developing endocrine pancreas is outlined to further illustrate this process...
March 26, 2015: Cell
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