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Metal allergy

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https://www.readbyqxmd.com/read/28627111/european-surveillance-system-on-contact-allergies-essca-results-with-the-european-baseline-series-2013-14
#1
W Uter, J C Amario-Hita, A Balato, B Ballmer-Weber, A Bauer, A Belloni Fortina, A Bircher, M M U Chowdhury, S M Cooper, A Dugonik, R Gallo, A Giménez-Arnau, J D Johansen, S M John, M Kieć-Świerczyńska, T Kmecl, B Kręcisz, F Larese Filon, V Mahler, M Pesonen, T Rustemeyer, A Sadowska-Przytocka, J Sánchez-Perez, S Schliemann, M L Schuttelaar, D Simon, R Spiewak, S Valiukeviciene, E Weisshaar, I R White, S M Wilkinson
BACKGROUND: Contact allergy is a common condition and can severely interfere with daily life or professional activities. Due to changes in exposures, a consequence of introduction of new substances, new products or formulations, and regulatory intervention, the spectrum of contact sensitisation changes. OBJECTIVE: To evaluate the current spectrum of contact allergy to allergens present in the European baseline series (EBS) across Europe. METHODS: Retrospective analysis of data collected by the European Surveillance System on Contact Allergies (ESSCA, www...
June 19, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28616704/metallic-ion-release-after-knee-prosthesis-implantation-a-prospective-study
#2
Adrien Lons, Sophie Putman, Gilles Pasquier, Henri Migaud, Elodie Drumez, Julien Girard
INTRODUCTION: Metal-on-metal (MoM) hip replacement bearings produce metallic ions that can cause health complications. Metallic release also occurs with other materials, but data on metallic ion levels after knee arthroplasty are sparse. We postulate that knee replacement generates elevating metallic ions (chromium (Cr), cobalt (Co) and titanium (Ti)) during the first year after implantation. PATIENTS AND METHODS: This ongoing prospective study included all patients who underwent the same type of knee arthroplasty between May and December 2013...
June 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28595206/transcatheter-closure-of-atrial-septal-defect-with-atrial-septal-occluder-in-a-patient-with-nickel-allergy
#3
Hasan Arı, Selma Arı, Ahmet Tütüncü, Alper Karakuş, Mehmet Melek
Presently described is transcatheter closure of atrial septal defect with atrial septal occluder (ASO) device in a patient with nickel allergy. Patients with metal allergy who will undergo nitinol device implantation should be tested for possible nickel hypersensitivity. ASO device and treatment strategy (percutaneous or surgical) should be selected according to allergy test result.
June 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28561797/trav7-2-02-expressing-cd8%C3%A2-%C2%BA-t-cells-are-responsible-for-palladium-allergy
#4
Yuri Takeda, Yoshiko Suto, Koyu Ito, Wataru Hashimoto, Tadashi Nishiya, Kyosuke Ueda, Takayuki Narushima, Tetsu Takahashi, Kouetsu Ogasawara
While metallic biomaterials have led to an improvement in the quality of life, metal allergies, especially to palladium (Pd), has caused a recent increase in allergic patients. Metal allergy is known to be a T cell-mediated delayed-type hypersensitivity (DTH); however, the pathogenic T cell subsets and the specific T cell receptor (TCR) have not been identified. Therefore, we attempted to identify the pathogenic T cells responsible for Pd allergy. We found that activating CD8⁺ T cells significantly increased and that the TRAV (TCRα variable) 7-2*02 chain skewed in Pd allergic mice...
May 31, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28492599/allergic-reaction-to-vanadium-causes-a-diffuse-eczematous-eruption-and-titanium-alloy-orthopedic-implant-failure
#5
Sally Engelhart, Robert J Segal
Allergy as a cause of adverse outcomes in patients with implanted orthopedic hardware is controversial. Allergy to titanium-based implants has not been well researched, as titanium is traditionally thought to be inert. We highlight the case of a patient who developed systemic dermatitis and implant failure after surgical placement of a titanium alloy (Ti6Al4V) plate in the left foot. The hardware was removed and the eruption cleared in the following weeks. The plate and screws were submitted for metal analysis...
April 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28466130/-environmental-pollutants-as-adjuvant-factors-of-immune-system-derived-diseases
#6
REVIEW
Irina Lehmann
The main task of the immune system is to protect the body against invading pathogens. To be able to do so, immune cells must be able to recognize and combat exogenous challenges and at the same time tolerate body-borne structures. A complex regulatory network controls the sensitive balance between defense and tolerance. Perturbation of this network ultimately leads to the development of chronic inflammation, such as allergies, autoimmune reactions, and infections, because the immune system is no longer able to efficiently eliminate invading pathogens...
May 2, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28444933/synergistic-effect-of-carbon-nuclei-and-polyaromatic-hydrocarbons-on-respiratory-and-immune-responses
#7
Pratiti H Chowdhury, Gaku Kitamura, Akiko Honda, Takahiro Sawahara, Tomohiro Hayashi, Wataru Fukushima, Hitomi Kudo, Sho Ito, Seiichi Yoshida, Takamichi Ichinose, Kayo Ueda, Hirohisa Takano
Particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5 ) is generally composed of carbon nuclei associated with various organic carbons, metals, ions and biological materials. Among these components, polyaromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BaP) and quinones have detrimental effects on airway epithelial cells and immunodisrupting effects, which leads to the exacerbation of respiratory allergies. The effects of PAHs and the carbon nuclei, separately as well as in combination, remain to be established...
April 26, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28415381/biocompatibility-study-on-ni-free-ti-based-and-zr-based-bulk-metallic-glasses
#8
T H Li, P C Wong, S F Chang, P H Tsai, J S C Jang, J C Huang
Safety and reliability are crucial issues for medical instruments and implants. In the past few decays, bulk metallic glasses (BMGs) have drawn attentions due to their superior mechanical properties, good corrosion resistance, antibacterial and good biocompatibility. However, most Zr-based and Ti-based BMGs contain Ni as an important element which is prone to human allergy problem. In this study, the Ni-free Ti-based and Zr-based BMGs, Ti40Zr10Cu36Pd14, and Zr48Cu36Al8Ag8, were selected for systematical evaluation of their biocompatibility...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28401153/metals-are-important-contact-sensitizers-an-experience-from-lithuania
#9
Kotryna Linauskienė, Laura Malinauskienė, Audra Blažienė
Background. Metals are very frequent sensitizers causing contact allergy and allergic contact dermatitis worldwide; up-to-date data based on patch test results has proved useful for the identification of a problem. Objectives. In this retrospective study prevalence of contact allergy to metals (nickel, chromium, palladium, gold, cobalt, and titanium) in Lithuania is analysed. Patients/Methods. Clinical and patch test data of 546 patients patch tested in 2014-2016, in Vilnius University Hospital Santariskiu Klinikos, was analysed and compared with previously published data...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28386993/nickel-allergy-in-a-danish-population-25%C3%A2-years-after-the-first-nickel-regulation
#10
Malin G Ahlström, Torkil Menné, Jacob P Thyssen, Jeanne D Johansen
BACKGROUND: Nickel in metallic items has been regulated in Denmark since 1990; however, 10% of young Danish women are still sensitized to nickel. There is a need for continuous surveillance of the effect of regulation. OBJECTIVES: To identify current self-reported metallic exposures leading to dermatitis in nickel-allergic patients, and the minimum contact time needed for dermatitis to occur. METHODS: A questionnaire was sent to all patients who reacted positively to nickel sulfate 5% pet...
April 7, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28364382/hypersensitivity-to-orthopedic-implants-a-review-of-the-literature
#11
REVIEW
Joseph Wawrzynski, Joseph A Gil, Avi D Goodman, Gregory R Waryasz
Awareness of rare etiologies for implant failure is becoming increasingly important. In addition to the overall increase in joint arthroplasties, revision surgeries are projected to increase dramatically in the coming years, with volume increasing up to seven-fold between 2005 and 2030. The literature regarding the relationship between metal allergy and implant failure is controversial. It has proven difficult to determine whether sensitization is a cause or a consequence of implant failure. Testing patients with functional implants is not a clinically useful approach, as the rate of hypersensitivity is higher in implant recipients than in the general population, regardless of the status of the implant...
June 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/28342246/hypohidrosis-and-metal-allergy-trigger-factors-for-unilateral-lichen-planus
#12
Takeshi Fukumoto, Shinji Tsuchiyama, Atsushi Fukunaga, Chikako Nishigori
Unilateral lichen planus (LP) is a rare clinical variant of LP. The etiology of unilateral LP has not been clarified, although various causes have been reported because of the characteristic distribution. We focused on the contribution of metal allergy and sweating in the development of unilateral LP in this case. To confirm the presence of metal allergy, patch tests with metal allergens were performed. To investigate the cause of the unilateral distribution in unilateral LP, the function of sweating and sweat leaking in the dermis was assessed by a thermoregulatory sweat test and immunohistochemical staining of dermcidin...
March 24, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28339013/immunological-effects-of-occupational-exposure-to-lead-review
#13
Concettina Fenga, Silvia Gangemi, Valentina Di Salvatore, Luca Falzone, Massimo Libra
It is well-known that occupational and environmental exposure to several factors, including benzene, heavy metals, chemicals and mineral fibers, is associated with the risk of developing a great number of diseases. Numerous studies have been carried out in order to investigate the mechanisms of toxicity of these substances, with particular regard to the possible toxic effects on the immune system. However, little is known about the influence of heavy metals, such as lead, on the immune system in human populations...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28319310/cxcl4-is-a-novel-nickel-binding-protein-and-augments-nickel-allergy
#14
Toshinobu Kuroishi, Kanan Bando, Yukinori Tanaka, Kaori Shishido, Masayuki Kinbara, Tomohisa Ogawa, Koji Muramoto, Yasuo Endo, Shunji Sugawara
BACKGROUND: Nickel (Ni) is the most frequent metal allergen and induces a TH1 -dependent type-IV allergy. Although Ni(2+) is considered to bind to endogenous proteins, it currently remains unclear whether these Ni-binding proteins are involved in Ni allergy in vivo. We previously reported the adjuvant effects of lipopolysaccharide (LPS) in a Ni allergy mouse model. Since LPS induces a number of inflammatory mediators, we hypothesized that Ni-binding protein(s) are also induced by LPS...
March 20, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28300831/immunoproteomic-identification-and-characterization-of-ni-2-regulated-proteins-implicates-ni-2-in-the-induction-of-monocyte-cell-death
#15
Annika Jakob, Franz Mussotter, Stefanie Ohnesorge, Lisa Dietz, Julian Pardo, Ian D Haidl, Hermann-Josef Thierse
Nickel allergy is the most common cause of allergic reactions worldwide, with cutaneous and systemic effects potentially affecting multiple organs. Monocytes are precursors of not only macrophages but also dendritic cells, the most potent activators of nickel hypersensitivity. Monocytes are themselves important antigen-presenting cells, capable of nickel-specific T-cell activation in vivo and in vitro, in addition to being important for immediate innate immune inflammation. To elucidate early Ni(2+)-dependent inflammatory molecular mechanisms in human monocytes, a Ni(2+)-specific proteomic approach was applied...
March 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28288455/diagnostic-tools-for-doctors-evaluation-of-tattoo-complications
#16
Jørgen Serup
Diagnosis of tattoo complications is a multi-facetted field since many clinical entities and disease mechanisms are represented. Infections, allergies, and pigment foreign body reactions with granuloma are the major groups. The clinician needs a structured approach to diagnosis and an armamentarium of standard tests. Diagnosis primarily builds on patient history, objective clinical examination, and punch biopsy, supplemented with microbiology testing, ultrasound scanning, and clinical photography. Evaluation of allergic tattoo reactions and allergy to pigments by patch testing is not applicable and has a falsely negative outcome except for the diagnosis of allergy to metals and preservatives...
2017: Current Problems in Dermatology
https://www.readbyqxmd.com/read/28243563/comparison-of-four-functionalization-methods-of-gold-nanoparticles-for-enhancing-the-enzyme-linked-immunosorbent-assay-elisa
#17
Paula Ciaurriz, Fátima Fernández, Edurne Tellechea, Jose F Moran, Aaron C Asensio
The enzyme-linked immunosorbent assay (ELISA) technique is based on the specific recognition ability of the molecular structure of an antigen (epitope) by an antibody and is likely the most important diagnostic technique used today in bioscience. With this methodology, it is possible to diagnose illness, allergies, alimentary fraud, and even to detect small molecules such as toxins, pesticides, heavy metals, etc. For this reason, any procedures that improve the detection limit, sensitivity or reduce the analysis time could have an important impact in several fields...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28220366/zirconia-implants-and-peek-restorations-for-the-replacement-of-upper-molars
#18
José María Parmigiani-Izquierdo, María Eugenia Cabaña-Muñoz, José Joaquín Merino, Arturo Sánchez-Pérez
BACKGROUND: One of the disadvantages of the zirconia implants is the lack of elasticity, which is increased with the use of ceramic or zirconia crowns. The consequences that could result from this lack of elasticity have led to the search for new materials with improved mechanical properties. CASE PRESENTATION: A patient who is a 45-year-old woman, non-smoker and has no medical record of interest with a longitudinal fracture in the palatal root of molar tooth 1...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28199353/oral-administration-of-lactobacillus-paracasei-l9-attenuates-pm2-5-induced-enhancement-of-airway-hyperresponsiveness-and-allergic-airway-response-in-murine-model-of-asthma
#19
Xifan Wang, Yan Hui, Liang Zhao, Yanling Hao, Huiyuan Guo, Fazheng Ren
This study investigated allergy immunotherapy potential of Lactobacillus paracasei L9 to prevent or mitigate the particulate matter 2.5 (PM2.5) enhanced pre-existing asthma in mice. Firstly, we used a mouse model of asthma (a 21-day ovalbumin (OVA) sensitization and challenge model) followed by PM2.5 exposure twice on the same day of the last challenge. PM2.5 was collected from the urban area of Beijing and underwent analysis for metals and polycyclic aromatic hydrocarbon contents. The results showed that PM2...
2017: PloS One
https://www.readbyqxmd.com/read/28167868/allergy-in-total-knee-replacement-does-it-exist-review-article
#20
REVIEW
Martin Faschingbauer, Lisa Renner, Friedrich Boettner
BACKGROUND: There is little data on whether preexisting allergies to implant materials and bone cement have an impact on the outcome of TKA. QUESTIONS/PURPOSES: This review article analyzes the current literature to evaluate the prevalence and importance of metal and cement allergies for patients undergoing total knee arthroplasty. METHODS: A review of the literature was performed using the following search criteria: "knee," "arthroplasty," and "allergy" as well as "knee," "arthroplasty," and "hypersensitivity...
February 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
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