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https://www.readbyqxmd.com/read/29785933/a-comparison-of-peripheral-imaging-technologies-for-bone-and-muscle-quantification-a-review-of-segmentation-techniques
#1
REVIEW
Andy Kin On Wong, Sarah Lynn Manske
Musculoskeletal science has developed many overlapping branches, necessitating specialists from 1 area of focus to often require the expertise in others. In terms of imaging, this means obtaining a comprehensive illustration of bone, muscle, and fat tissues. There is currently a lack of a reliable resource for end users to learn about these tissues' imaging and quantification techniques together. An improved understanding of these tissues has been an important progression toward better prediction of disease outcomes and better elucidation of their interaction with frailty, aging, and metabolic disorders...
April 17, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29785732/the-mental-representation-of-human-action
#2
Sydney Levine, Alan M Leslie, John Mikhail
Various theories of moral cognition posit that moral intuitions can be understood as the output of a computational process performed over structured mental representations of human action. We propose that action plan diagrams-"act trees"-can be a useful tool for theorists to succinctly and clearly present their hypotheses about the information contained in these representations. We then develop a methodology for using a series of linguistic probes to test the theories embodied in the act trees. In Study 1, we validate the method by testing a specific hypothesis (diagrammed by act trees) about how subjects are representing two classic moral dilemmas and finding that the data support the hypothesis...
May 21, 2018: Cognitive Science
https://www.readbyqxmd.com/read/29784670/cancer-as-a-social-dysfunction-why-cancer-research-needs-new-thinking
#3
Kenneth J Pienta, Robert Axelrod
The incidence and mortality for many cancers continues to rise. As such, critical action is needed on many fronts to reshape how a society thinks, discusses, and fights cancer especially as the population grows and ages. Cancer can be described as a broken social contract which requires different conceptual frameworks such as game theory. To this end, it is our hope that this perspective will catalyze a discussion to rethink the way we approach, communicate, and fund cancer research - thinking of cancer as a broken social contract is only one example...
May 21, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29784537/artificial-intelligence-a-joint-narrative-on-potential-use-in-pediatric-stem-and-immune-cell-therapies-and-regenerative-medicine
#4
REVIEW
Irena Sniecinski, Jerard Seghatchian
Artificial Intelligence (AI) reflects the intelligence exhibited by machines and software. It is a highly desirable academic field of many current fields of studies. Leading AI researchers describe the field as "the study and design of intelligent agents". McCarthy invented this term in 1955 and defined it as "the science and engineering of making intelligent machines". The central goals of AI research are reasoning, knowledge, planning, learning, natural language processing (communication), perception and the ability to move and manipulate objects...
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29782219/soft-robotics-academic-insights-and-perspectives-through-bibliometric-analysis
#5
Guanjun Bao, Hui Fang, Lingfeng Chen, Yuehua Wan, Fang Xu, Qinghua Yang, Libin Zhang
Soft robotics is of growing interest in the robot community as well as in public media, and there is an increase in the quality and quantity of publications related to this topic. To formally elaborate this growth, we have used a bibliometric analysis to evaluate the publications in the field from 1990 to 2017 based on the Science Citation Index Expanded database. We present a detailed overview and discussion based on keywords, citation, h-index, year, journal, institution, country, author, and review articles...
May 21, 2018: Soft Robotics
https://www.readbyqxmd.com/read/29781710/a-computationally-more-efficient-and-more-accurate-stepwise-approach-for-correcting-for-sampling-error-and-measurement-error
#6
Steffen Zitzmann
Over the last decade or two, multilevel structural equation modeling (ML-SEM) has become a prominent modeling approach in the social sciences because it allows researchers to correct for sampling and measurement errors and thus to estimate the effects of Level 2 (L2) constructs without bias. Because the latent variable modeling software Mplus uses maximum likelihood (ML) by default, many researchers in the social sciences have applied ML to obtain estimates of L2 regression coefficients. However, one drawback of ML is that covariance matrices of the predictor variables at L2 tend to be degenerate, and thus, estimates of L2 regression coefficients tend to be rather inaccurate when sample sizes are small...
May 21, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29780742/caries-risk-assessment-of-12-13-year-old-government-and-private-school-going-children-of-mysore-city-using-cariogram-a-comparative-study
#7
Sandhya P Naik, Shabna Moyin, Bhakti Patel, Lata Prabhu Warad, Sameer Punathil, C B Sudeep
Aim: The aim of this study is to assess the caries risk assessment of 12-13-year-old government and private school going children of Mysore city using Cariogram. Materials and Methods: A cross-sectional examination was carried out on a total of 104 government and private schoolchildren aged 12-13 years. Ten factors from the Cariogram software(D Bratthall, Computer software, Malmo, Sweden) were included from study participant's records to complete the Cariogram. The percentage of "chances of avoiding new lesions" (caries risk) among government and private school study participants were obtained from Cariogram, and the participants were classified into five risk groups...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29780432/-in-silico-toxicology-comprehensive-benchmarking-of-multi-label-classification-methods-applied-to-chemical-toxicity-data
#8
REVIEW
Arwa B Raies, Vladimir B Bajic
One goal of toxicity testing, among others, is identifying harmful effects of chemicals. Given the high demand for toxicity tests, it is necessary to conduct these tests for multiple toxicity endpoints for the same compound. Current computational toxicology methods aim at developing models mainly to predict a single toxicity endpoint. When chemicals cause several toxicity effects, one model is generated to predict toxicity for each endpoint, which can be labor and computationally intensive when the number of toxicity endpoints is large...
May 2018: Wiley Interdisciplinary Reviews. Computational Molecular Science
https://www.readbyqxmd.com/read/29778926/a-computational-approach-to-estimate-postmortem-interval-using-opacity-development-of-eye-for-human-subjects
#9
İsmail Cantürk, Lale Özyılmaz
This paper presents an approach to postmortem interval (PMI) estimation, which is a very debated and complicated area of forensic science. Most of the reported methods to determine PMI in the literature are not practical because of the need for skilled persons and significant amounts of time, and give unsatisfactory results. Additionally, the error margin of PMI estimation increases proportionally with elapsed time after death. It is crucial to develop practical PMI estimation methods for forensic science. In this study, a computational system is developed to determine the PMI of human subjects by investigating postmortem opacity development of the eye...
May 17, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29776710/pharmacokinetics-pharmacodynamics-computer-decision-support-technologies-and-antimicrobial-stewardship-the-compass-and-rudder
#10
REVIEW
Robert C Owens, Catharine C Bulik, David R Andes
The first guidelines for conducting antimicrobial stewardship in the hospitalized setting were published in 2007. These guidelines recommend that stewardship programs employ the science of pharmacokinetics-pharmacodynamics (PK-PD) as well as adopting computerized decision support technologies when possible. The United States Food and Drug Administration have adopted PK-PD as a cornerstone in the evaluation of antimicrobial agents during clinical development. The core principles of PK-PD center around describing the relationship between drug exposure indexed to the susceptibility of the infecting bacterial pathogen and patient response...
April 13, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29774229/web-pages-what-can-you-see-in-a-single-fixation
#11
Ali Jahanian, Shaiyan Keshvari, Ruth Rosenholtz
Research in human vision suggests that in a single fixation, humans can extract a significant amount of information from a natural scene, e.g. the semantic category, spatial layout, and object identities. This ability is useful, for example, for quickly determining location, navigating around obstacles, detecting threats, and guiding eye movements to gather more information. In this paper, we ask a new question: What can we see at a glance at a web page - an artificial yet complex "real world" stimulus? Is it possible to notice the type of website, or where the relevant elements are, with only a glimpse? We find that observers, fixating at the center of a web page shown for only 120 milliseconds, are well above chance at classifying the page into one of ten categories...
2018: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29771841/integrating-a-profile-of-frontal-face-with-its-mirror-image-for-facial-reconstruction
#12
Paramjit Kaur, Kewal Krishan, Suresh K Sharma, Tanuj Kanchan
INTRODUCTION AND OBJECTIVES: Face recognition plays an important role in the field of biometrics, bioinformatics, and forensic identification. Human faces appear bilaterally symmetric. However, asymmetry is a norm in the human body and careful morphological and metric examination of the human face gives an exact idea of the asymmetry present in the face of an individual. Most of the studies on asymmetry of human face have been carried out with regard to evaluation of expressions in psychology, anthropology, and biometrics...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29770321/developing-workforce-capacity-in-public-health-informatics-core-competencies-and-curriculum-design
#13
Douglas R Wholey, Martin LaVenture, Sripriya Rajamani, Rob Kreiger, Craig Hedberg, Cynthia Kenyon
We describe a master's level public health informatics (PHI) curriculum to support workforce development. Public health decision-making requires intensive information management to organize responses to health threats and develop effective health education and promotion. PHI competencies prepare the public health workforce to design and implement these information systems. The objective for a Master's and Certificate in PHI is to prepare public health informaticians with the competencies to work collaboratively with colleagues in public health and other health professions to design and develop information systems that support population health improvement...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29769297/mechanistic-models-versus-machine-learning-a-fight-worth-fighting-for-the-biological-community
#14
REVIEW
Ruth E Baker, Jose-Maria Peña, Jayaratnam Jayamohan, Antoine Jérusalem
Ninety per cent of the world's data have been generated in the last 5 years ( Machine learning: the power and promise of computers that learn by example Report no. DES4702. Issued April 2017. Royal Society). A small fraction of these data is collected with the aim of validating specific hypotheses. These studies are led by the development of mechanistic models focused on the causality of input-output relationships. However, the vast majority is aimed at supporting statistical or correlation studies that bypass the need for causality and focus exclusively on prediction...
May 2018: Biology Letters
https://www.readbyqxmd.com/read/29769140/local-infiltration-anesthesia-versus-epidural-analgesia-for-postoperative-pain-control-in-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#15
Chen Li, Ji Qu, Su Pan, Yang Qu
BACKGROUND: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of local infiltration anesthesia (LIA) versus epidural analgesia (EPA) for postoperative pain control in total knee arthroplasty (TKA). METHODS: In December 2017, a systematic computer-based search was conducted in Pubmed, EMBASE, Web of Science, and Cochrane Database of Systematic Reviews. RCTs of patients prepared for spine surgery that compared LIA versus EPA for postoperative pain control in TKA were retrieved...
May 16, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29768999/essentials-and-perspectives-of-computational-modelling-assistance-for-cns-oriented-nanoparticle-based-drug-delivery-systems
#16
Joanna Kisała, Kinga I Heclik, Krzysztof Pogocki, Dariusz Pogocki
The blood-brain barrier (BBB) is a complex system controlling two-way substances traffic between circulatory (cardiovascular) system and central nervous system (CNS). It is almost perfectly crafted to regulate brain homeostasis and to permit selective transport of molecules that are essential for brain function. For potential drug candidates, the CNS-oriented neuropharmaceuticals as well as for those of primary targets in the periphery, the extent to which a substance in the circulation gains access to the CNS seems crucial...
May 16, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29768436/the-effectiveness-of-various-computer-based-interventions-for-patients-with-chronic-pain-or-functional-somatic-syndromes-a-systematic-review-and-meta-analysis
#17
Miel A P Vugts, Margot C W Joosen, Jessica E van der Geer, Aglaia M E E Zedlitz, Hubertus J M Vrijhoef
Computer-based interventions target improvement of physical and emotional functioning in patients with chronic pain and functional somatic syndromes. However, it is unclear to what extent which interventions work and for whom. This systematic review and meta-analysis (registered at PROSPERO, 2016: CRD42016050839) assesses efficacy relative to passive and active control conditions, and explores patient and intervention factors. Controlled studies were identified from MEDLINE, EMBASE, PsychInfo, Web of Science, and Cochrane Library...
2018: PloS One
https://www.readbyqxmd.com/read/29765315/challenges-in-reproducibility-replicability-and-comparability-of-computational-models-and-tools-for-neuronal-and-glial-networks-cells-and-subcellular-structures
#18
Tiina Manninen, Jugoslava Aćimović, Riikka Havela, Heidi Teppola, Marja-Leena Linne
The possibility to replicate and reproduce published research results is one of the biggest challenges in all areas of science. In computational neuroscience, there are thousands of models available. However, it is rarely possible to reimplement the models based on the information in the original publication, let alone rerun the models just because the model implementations have not been made publicly available. We evaluate and discuss the comparability of a versatile choice of simulation tools: tools for biochemical reactions and spiking neuronal networks, and relatively new tools for growth in cell cultures...
2018: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/29763790/the-language-of-smell-connecting-linguistic-and-psychophysical-properties-of-odor-descriptors
#19
Georgios Iatropoulos, Pawel Herman, Anders Lansner, Jussi Karlgren, Maria Larsson, Jonas K Olofsson
The olfactory sense is a particularly challenging domain for cognitive science investigations of perception, memory, and language. Although many studies show that odors often are difficult to describe verbally, little is known about the associations between olfactory percepts and the words that describe them. Quantitative models of how odor experiences are described in natural language are therefore needed to understand how odors are perceived and communicated. In this study, we develop a computational method to characterize the olfaction-related semantic content of words in a large text corpus of internet sites in English...
May 12, 2018: Cognition
https://www.readbyqxmd.com/read/29763318/on-the-peculiar-molecular-shape-and-size-dependence-of-the-dynamics-of-fluids-confined-in-a-small-pore-metal-organic-framework
#20
Ioannis Skarmoutsos, Mohamed Eddaoudi, Guillaume Maurin
Force field based-Molecular dynamics simulations were deployed to systematically explore the dynamics of confined molecules of different shapes and sizes, i.e. linear (CO2 and N2) and spherical (CH4) fluids, in a model small pore system, i.e. the Metal-Organic Framework SIFSIX-2-Cu-i. These computations unveil an unprecedented molecular symmetry dependence of the translational and rotational dynamics of fluids confined in channel-like nanoporous materials. In particular this peculiar behaviour is reflected by the extremely slow decay of the Legendre reorientational correlation functions of even-parity order for the linear fluids which is associated to jump-like orientation flips, while the spherical fluid shows a very fast decay taking place in a sub-picosecond time scale...
May 15, 2018: Journal of Physical Chemistry Letters
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