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Statin and TB

Joseph B Lerman, Aditya A Joshi, Abhishek Chaturvedi, Tsion M Aberra, Amit K Dey, Justin A Rodante, Taufiq Salahuddin, Jonathan H Chung, Anshuma Rana, Heather L Teague, Jashin J Wu, Martin P Playford, Benjamin A Lockshin, Marcus Y Chen, Veit Sandfort, David A Bluemke, Nehal N Mehta
BACKGROUND: Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides an ideal human model to study inflammatory atherogenesis in vivo. We hypothesized that the increased cardiovascular risk observed in psoriasis would be partially attributable to an elevated subclinical coronary artery disease burden composed of noncalcified plaques with high-risk features. However, inadequate efforts have been made to directly measure coronary artery disease in this vulnerable population...
July 18, 2017: Circulation
Vincent Yi-Fong Su, Wei-Juin Su, Yung-Feng Yen, Sheng-Wei Pan, Pei-Hung Chuang, Jia-Yih Feng, Kun-Ta Chou, Kuang-Yao Yang, Yu-Chin Lee, Tzeng-Ji Chen
BACKGROUND: Statins are widely used to lower cholesterol levels and cardiovascular risk. Further, studies have shown that statins may decrease the risks of infectious diseases and infection-related mortality; however, the association between statin use and active TB disease remains unclear. METHODS: Using the Taiwan National Health Insurance Research Database, we conducted a nationwide population-based study. Patients taking statins between 2000 and 2013, without antecedent TB disease, were included...
September 2017: Chest
Inmaculada Medina-Caliz, Mercedes Robles-Diaz, Beatriz Garcia-Muñoz, Camilla Stephens, Aida Ortega-Alonso, Miren Garcia-Cortes, Andres González-Jimenez, Judith A Sanabria-Cabrera, Inmaculada Moreno, M Carmen Fernandez, Manuel Romero-Gomez, Jose M Navarro, Ana M Barriocanal, Eva Montane, Hacibe Hallal, Sonia Blanco, German Soriano, Eva M Roman, Elena Gómez-Dominguez, Agustin Castiella, Eva M Zapata, Miguel Jimenez-Perez, Jose M Moreno, Ana Aldea-Perona, Manuel Hernández-Guerra, Martin Prieto, Miguel E Zoubek, Neil Kaplowitz, M Isabel Lucena, Raul J Andrade
BACKGROUND & AIMS: Chronic outcome following acute idiosyncratic drug-induced liver injury (DILI) is not yet defined. This prospective, long-term follow-up study aimed to analyze time to liver enzyme resolutions to establish the best definition and risk factors of DILI chronicity. METHODS: 298 out of 850 patients in the Spanish DILI registry with no pre-existing disease affecting the liver and follow-up to resolution or ⩾1year were analyzed. Chronicity was defined as abnormal liver biochemistry, imaging test or histology one year after DILI recognition...
September 2016: Journal of Hepatology
Chih-Cheng Lai, Meng-Tse Gabriel Lee, Shih-Hao Lee, Wan-Ting Hsu, Shy-Shin Chang, Shyr-Chyr Chen, Chien-Chang Lee
BACKGROUND: Epidemiological data suggest that statins improve the clinical outcome of respiratory infections. We sought to examine whether statin therapy decreases the risk of active TB. METHODS: We conducted a nested case-control study on data obtained from a national health insurance claims database between 1999 and 2011. The use of statins was classified as current, recent, past or chronic use. Three conditional logistic regression models were used to estimate the incidence rate ratios (RRs)...
July 2016: Thorax
Noton K Dutta, Natalie Bruiners, Michael L Pinn, Matthew D Zimmerman, Brendan Prideaux, Véronique Dartois, Maria L Gennaro, Petros C Karakousis
BACKGROUND: The repurposing of existing agents may accelerate TB drug development. Recently, we reported that the lipid-lowering drug simvastatin, when added to the first-line antitubercular regimen, reduces the lung bacillary burden in chronically infected mice. OBJECTIVES: We investigated whether the addition of simvastatin to the first-line regimen (isoniazid/rifampicin/pyrazinamide) shortens the duration of curative TB treatment in mice. METHODS: Mycobacterium tuberculosis-infected THP-1 cells were exposed to simvastatin to determine the effect of statins on the activity of first-line anti-TB drug activity and intracellular rifampicin concentration...
June 2016: Journal of Antimicrobial Chemotherapy
Jingjing Sheng, Xiaoting Tian, Guanglin Xu, Zhitao Wu, Chen Chen, Le Wang, Lili Pan, Chenggang Huang, Guoyu Pan
The purpose of this study was to characterize the hepatobiliary disposition of timosaponin B2 (TB-2), a natural saponin. Although TB-2 has multiple pharmacologic activities, the mechanism of its hepatobiliary disposition has not been explored. Because the metabolism of TB-2 is limited and the accumulation of TB-2 in primary hepatocytes is highly temperature dependent (93% of its accumulation is due to active uptake), the contribution of hepatic transporters was investigated. Organic anion-transporting polypeptide (OATP) 1B1- and OATP1B3-transfected human embryonic kidney 293 cells were employed...
January 2015: Drug Metabolism and Disposition: the Biological Fate of Chemicals
Lívia Silva Lobato, Patrícia Sammarco Rosa, Jessica da Silva Ferreira, Arthur da Silva Neumann, Marlei Gomes da Silva, Dejair Caitano do Nascimento, Cleverson Teixeira Soares, Silvia Cristina Barbosa Pedrini, Diego Sá Leal de Oliveira, Cláudia Peres Monteiro, Geraldo Moura Batista Pereira, Marcelo Ribeiro-Alves, Mariana Andrea Hacker, Milton Ozório Moraes, Maria Cristina Vidal Pessolani, Rafael Silva Duarte, Flávio Alves Lara
Mycobacterium leprae and Mycobacterium tuberculosis antimicrobial resistance has been followed with great concern during the last years, while the need for new drugs able to control leprosy and tuberculosis, mainly due to extensively drug-resistant tuberculosis (XDR-TB), is pressing. Our group recently showed that M. leprae is able to induce lipid body biogenesis and cholesterol accumulation in macrophages and Schwann cells, facilitating its viability and replication. Considering these previous results, we investigated the efficacies of two statins on the intracellular viability of mycobacteria within the macrophage, as well as the effect of atorvastatin on M...
October 2014: Antimicrobial Agents and Chemotherapy
Y A Kang, N-K Choi, J-M Seong, E Y Heo, B K Koo, S-S Hwang, B-J Park, J-J Yim, C-H Lee
OBJECTIVE: To evaluate whether statin use affects the development of tuberculosis (TB) among patients with diabetes mellitus (DM). METHODS: This is a retrospective cohort study of patients with newly diagnosed type 2 DM based on the South Korean nationwide claims database. The participants were type 2 DM patients aged 20-99 years who were newly treated with anti-diabetic drugs between 1 January 2007 and 31 December 2010. Patients who had statin prescriptions before a diagnosis of diabetes or were diagnosed with TB before diabetes were excluded...
June 2014: International Journal of Tuberculosis and Lung Disease
Ciaran Skerry, Michael L Pinn, Natalie Bruiners, Richard Pine, Maria L Gennaro, Petros C Karakousis
BACKGROUND: The need to develop new, improved treatments for tuberculosis (TB) remains urgent, and the repurposing of existing drugs represents a possible shortcut to market. Recently, there has been significant interest in host-directed adjuvant therapy to enhance bacillary killing. HMG-CoA reductase inhibitors (statins), which are among the most commonly prescribed drugs, have immunomodulatory properties and improve the clinical outcomes of bacterial infections. METHODS: We studied the tuberculocidal activity of simvastatin alone and in combination with first-line anti-TB drugs in J774 macrophages and during chronic TB infection...
September 2014: Journal of Antimicrobial Chemotherapy
Xiao-Jv Zou, Yi-Hong Ding, Bin Liang
Originally grown and produced in southern of Yunnan, China, Pu-erh tea has a long history and carries rich cultural connotations. Consumption of Pu-erh has been thought to possess numerous health benefits including weight-loss, lowering of blood glucose levels, and preventing cardiovascular diseases. Research on humans, rodents, and cell lines have each confirmed that Pu-erh tea indeed displays weight-loss and blood lipid lowering effects. The main bioactive components, such as theabrownin (TB), polysaccharides, polyphenols, and statins, may down-regulate the biosynthesis of fat and up-regulate the oxidation of fat to cut weight and reduce the content of lipids in blood...
August 2012: Dong Wu Xue Yan Jiu, Zoological Research
Catherine Lane, Anthony Ashcroft, Graham Bothamley, Magdi M Yaqoob, Stanley L-S Fan
BACKGROUND: The QuantiFERON® test (QFT) is a diagnostic tool for active and latent tuberculosis (TB) infections. High rates of positivity to QuantiFERON® have been demonstrated in patients with chronic kidney disease (CKD) and diabetic patients. We performed a pilot study to investigate if QFT positivity in diabetic CKD patients predicted the rate of renal function decline. METHODS: QFT was performed in 38 diabetic patients with CKD 4-5 not on dialysis. The rate of decline in estimated glomerular filtration rate (eGFR) was calculated...
2011: Nephron. Clinical Practice
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