Refaat A Eid, Mashael Mohammed Bin-Meferij, Attalla Farag El-Kott, Samy M Eleawa, Mohamed Samir Ahmed Zaki, Mubarak Al-Shraim, Fahmy El-Sayed, Muhammad Alaa Eldeen, Mahmoud A Alkhateeb, Samah A Alharbi, Hussain Aldera, Mohammad A Khalil
This study evaluated if the cardioprotective effect of Exendin-4 against ischemia/reperfusion (I/R) injury in male rats involves modulation of AMPK and sirtuins. Adult male rats were divided into sham, sham + Exendin-4, I/R, I/R + Exendin-4, and I/R + Exendin-4 + EX-527, a sirt1 inhibitor. Exendin-4 reduced infarct size and preserved the function and structure of the left ventricles (LV) of I/R rats. It also inhibited oxidative stress and apoptosis and upregulated MnSOD and Bcl-2 in their infarcted myocardium...
April 1, 2020: Journal of Cardiovascular Translational Research