Dandong Fang, Yu Li, Bo He, Daqian Gu, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Ming Tang, Xingbing Li, Donghai Yang, Chunmei Xu, Yijie Hu, Hongyong Wang, Pedro A Jose, Yu Han, Chunyu Zeng
Myocardial dysfunction is the most serious complication of sepsis. Sepsis-induced myocardial dysfunction (SMD) is often associated with gastrointestinal dysfunction, but its pathophysiological significance remains unclear. The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD. In mice, knockdown of the gastrin receptor, cholecystokinin B receptor ( Cckbr ), aggravated lipopolysaccharide (LPS)-induced cardiac dysfunction and increased inflammation in the heart, whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury...
September 2023: Acta Pharmaceutica Sinica. B