keyword
MENU ▼
Read by QxMD icon Read
search

treatment of myocardial dysfunction in sepsis

keyword
https://www.readbyqxmd.com/read/27908339/vasopressors-and-inotropes-in-sepsis
#1
REVIEW
Leeanne Stratton, David A Berlin, John E Arbo
Vasopressor and inotropes are beneficial in shock states. Norepinephrine is considered the first-line vasopressor for patients with sepsis-associated hypotension. Dobutamine is considered the first-line inotrope in sepsis, and should be considered for patients with evidence of myocardial dysfunction or ongoing signs of hypoperfusion. Vasopressor and inotrope therapy has complex effects that are often difficult to predict; emergency providers should consider the physiology and clinical trial data. It is essential to continually reevaluate the patient to determine if the selected treatment is having the intended result...
February 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/27716530/naringin-protects-against-lipopolysaccharide-induced-cardiac-injury-in-mice
#2
Liu Xianchu, Professor Zheng Lan, Li Qiufang, Liu Yi, Ruan Xiangcheng, Hou Wenqi, Ding Yang
Previous research has demonstrated that lipopolysaccharide (LPS) can induce sepsis and lead to myocardial dysfunction. Naringin has various biological activities in LPS-induced sepsis. In this study, our aim was to investigate the effects of Naringin on LPS-induced cardiac injury and clarify its potential mechanism. We found that in vivo treatment with Naringin significantly ameliorated body weight loss, and attenuated cardiac histopathological changes after LPS challenge. Furthermore, Naringin inhibited LPS-induced increase of TNF-α, IL-1β and IL-6 activities to alleviate inflammatory response in heart...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27709263/refractory-septic-shock-in-children-a-european-society-of-paediatric-and-neonatal-intensive-care-definition
#3
Luc Morin, Samiran Ray, Clare Wilson, Solenn Remy, Mohamed Rida Benissa, Nicolaas J G Jansen, Etienne Javouhey, Mark J Peters, Martin Kneyber, Daniele De Luca, Simon Nadel, Luregn Jan Schlapbach, Graeme Maclaren, Pierre Tissieres
PURPOSE: Although overall paediatric septic shock mortality is decreasing, refractory septic shock (RSS) is still associated with high mortality. A definition for RSS is urgently needed to facilitate earlier identification and treatment. We aim to establish a European society of paediatric and neonatal intensive care (ESPNIC) experts' definition of paediatric RSS. METHODS: We conducted a two-round Delphi study followed by an observational multicentre retrospective study...
December 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27620887/cardiac-electrical-and-structural-changes-during-bacterial-infection-an-instructive-model-to-study-cardiac-dysfunction-in-sepsis
#4
Michael A Makara, Ky V Hoang, Latha P Ganesan, Elliot D Crouser, John S Gunn, Joanne Turner, Larry S Schlesinger, Peter J Mohler, Murugesan V S Rajaram
BACKGROUND: Sepsis patients with cardiac dysfunction have significantly higher mortality. Although several pathways are associated with myocardial damage in sepsis, the precise cause(s) remains unclear and treatment options are limited. This study was designed to develop a new model to investigate the early events of cardiac damage during sepsis progression. METHODS AND RESULTS: Francisella tularensis subspecies novicida (Ft.n) is a Gram-negative intracellular pathogen causing severe sepsis syndrome in mice...
September 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27569679/diastolic-dysfunction-in-the-critically-ill-patient
#5
J C Suárez, P López, J Mancebo, L Zapata
Left ventricular diastolic dysfunction is a common finding in critically ill patients. It is characterized by a progressive deterioration of the relaxation and the compliance of the left ventricle. Two-dimensional and Doppler echocardiography is a cornerstone in its diagnosis. Acute pulmonary edema associated with hypertensive crisis is the most frequent presentation of diastolic dysfunction critically ill patients. Myocardial ischemia, sepsis and weaning failure from mechanical ventilation also may be associated with diastolic dysfunction...
August 25, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/27434571/-the-role-of-mitochondrial-permeability-transition-pore-in-the-occurrence-of-septic-myocardial-depression
#6
Shanzi Jin, Sheng Wang
Sepsis is defined as life-threatening organ dysfunction caused by a dys-regulated host response to infection and septic myocardial depression (SMD) is a common complication. Pathogenesis of SMD is complicated and there is lack of specific treatment. Mitochondrial damage is an important pathological basis of SMD, and mitochondrial permeability transition pore (MPTP) plays an important role in maintaining the normal structure and function of the mitochondria. The change of MPTP during sepsis is summarized in this review so as to reveal the significant mechanism of MPTP in the occurrence of SMD...
August 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27355401/beneficial-effect-of-intermedin-1-53-in-septic-shock-rats-contributions-of-rho-kinase-and-bkca-pathway-mediated-improvement-in-cardiac-function
#7
Tao Li, Zhu Yu, Wu Huiling, Wu Yue, Zhang Jie, Peng Xiaoyong, Zang Jiatao, Xiang Xinming, Liangming Liu
OBJECTIVE: Intermedin (IMD) is a calcitonin gene-related peptide shown to have a protective effect on myocardial function in ischemia-reperfusion injury. Whether IMD has beneficial effect in severe sepsis and septic shock (and its underlying mechanisms) is not known. METHODS: We induced septic shock using cecal ligation and puncture (CLP). We focused on the potential beneficial effect of IMD1-53 on cardiac papillary muscle and cardiomyocytes against septic shock and its relationship with protection of cardiac function...
June 28, 2016: Shock
https://www.readbyqxmd.com/read/27338886/%C3%AE-blockers-in-sepsis-protocol-for-a-systematic-review-and-meta-analysis-of-randomised-control-trials
#8
Erick H Duan, Simon J W Oczkowski, Emilie Belley-Cote, Richard Whitlock, Francois Lamontagne, Phillip J Devereaux, Deborah J Cook
INTRODUCTION: Sepsis is a common and deadly complication of infection. As part of the host response, sympathetic stimulation can result in septic myocardial depression, and metabolic, haematological and immunological dysfunction. Administration of β-blockers may attenuate this pathophysiological response to infection, but the effects on clinical outcomes are unknown. The objective of this systematic review is to determine the efficacy and safety of β-blockers in adults with sepsis using data from randomised control trials...
2016: BMJ Open
https://www.readbyqxmd.com/read/27317946/north-american-ginseng-inhibits-myocardial-nox2-erk1-2-signaling-and-tumor-necrosis-factor-%C3%AE-expression-in-endotoxemia
#9
Yan Wu, Chaoyi Qin, Xiangru Lu, Jocelyn Marchiori, Qingping Feng
Sepsis is a systemic inflammatory response to infection with a high mortality but has no specific treatment despite decades of research. North American (NA) ginseng (Panax quinquefolius) is a popular natural health product with anti-oxidant and anti-inflammatory properties. The aim of the present study was to investigate the effects of NA ginseng on pro-inflammatory cytokine expression and cardiac function in endotoxemia, a model of sepsis. Mice were challenged with lipopolysaccharide (LPS) to induce endotoxemia...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27168089/levosimendan-new-indications-and-evidence-for-reduction-in-perioperative-mortality
#10
Antonio Pisano, Giacomo Monti, Giovanni Landoni
PURPOSE OF REVIEW: In the last years, the perioperative use of levosimendan in cardiac surgery patients is spreading. Moreover, newer indications have been suggested such as the treatment of sepsis-associated myocardial dysfunction. In the present review, we discuss the most recent evidences in these settings. RECENT FINDINGS: Levosimendan has been seemingly confirmed to reduce mortality in patients undergoing cardiac surgery. In particular, it appears to be the only inotropic drug to have a favorable effect on survival in any clinical setting...
August 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27098997/attenuation-of-the-lps-induced-erk-mediated-upregulation-of-fibrosis-related-factors-fgf-2-upa-mmp-2-and-mmp-9-by-carthamus-tinctorius-l-in-cardiomyoblasts
#11
Chien-Kuo Han, Yun-Chen Tien, Dennis Jine-Yuan Hsieh, Tsung-Jung Ho, Chao-Hung Lai, Yu-Lan Yeh, Cecilia Hsuan Day, Chia-Yao Shen, Hsi-Hsien Hsu, Jing-Ying Lin, Chih-Yang Huang
Severe and potentially fatal hypotension and cardiac contractile dysfunction are common symptoms in patients with sepsis. LPS was previously found to dramatically upregulate expression of fibrosis-related factors FGF-2, uPA, MMP-2, and MMP-9 in primary cardiac fibroblasts. MMPs are capable of denaturing and degrading fibrillar collagens and other components of the extracellular matrix (ECM). Studies have shown that dysregulation of expression of MMPs is associated with development of myocardial extracellular matrix remodeling and cardiac fibrosis, which contribute to progression of heart failure...
April 20, 2016: Environmental Toxicology
https://www.readbyqxmd.com/read/26982508/neural-control-of-inflammation-implications-for-perioperative-and-critical-care
#12
REVIEW
Benjamin E Steinberg, Eva Sundman, Niccolo Terrando, Lars I Eriksson, Peder S Olofsson
Inflammation and immunity are regulated by neural reflexes. Recent basic science research has demonstrated that a neural reflex, termed the inflammatory reflex, modulates systemic and regional inflammation in a multiplicity of clinical conditions encountered in perioperative medicine and critical care. In this review, the authors describe the anatomic and physiologic basis of the inflammatory reflex and review the evidence implicating this pathway in the modulation of sepsis, ventilator-induced lung injury, postoperative cognitive dysfunction, myocardial ischemia-reperfusion injury, and traumatic hemorrhage...
May 2016: Anesthesiology
https://www.readbyqxmd.com/read/26858715/macrophage-migration-inhibitory-factor-in-clinical-kidney-disease
#13
REVIEW
Annette Bruchfeld, Mårten Wendt, Edmund J Miller
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine implicated in acute and chronic inflammatory conditions, including sepsis, autoimmune disease, atherogenesis, plaque instability, and pulmonary arterial hypertension. MIF in plasma and urine is significantly elevated in patients with acute kidney injury (AKI) and elevated MIF in serum is associated with markers of oxidative stress, endothelial dysfunction, arterial stiffness, and markers of myocardial damage in chronic kidney disease (CKD)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26806307/lncrna-hotair-promotes-tnf-%C3%AE-production-in-cardiomyocytes-of-lps-induced-sepsis-mice-by-activating-nf-%C3%AE%C2%BAb-pathway
#14
Hongwei Wu, Jinfeng Liu, Wei Li, Gang Liu, Zhenguang Li
BACKGROUND: Mounting studies have illustrated an important role of HOTAIR in cancer progress, but few studies have reported its function in cardiac disease, including cardiac-associated sepsis. This study aimed to investigate the function of HOTAIR in sepsis, involving its association with the level of tumor necrosis factor-alpha (TNF-α), an important inducer of myocardial dysfunction during LPS-induced sepsis. METHODS: Sepsis mice model was established by LPS administration, and myocardial dysfunction was evaluated with hemodynamic parameters...
February 26, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26793347/the-role-of-speckle-tracking-echocardiography-in-assessment-of-lipopolysaccharide-induced-myocardial-dysfunction-in-mice
#15
Ming Chu, Yao Gao, Yanjuan Zhang, Bin Zhou, Bingruo Wu, Jing Yao, Di Xu
BACKGROUND: Sepsis-induced myocardial dysfunction is a common and severe complication of septic shock. Conventional echocardiography often fails to reveal myocardial depression in severe sepsis due to hemodynamic changes; in contrast, decline of strain measurements by speckle tracking echocardiography (STE) may indicate impaired cardiac function. This study investigates the role of STE in detecting lipopolysaccharide (LPS)-induced cardiac dysfunction with mouse models. METHODS: We evaluated cardiac function in 20 mice at baseline, 6 h (n=10) and 20 h (n=10) after LPS injection to monitor the development of heart failure induced by severe sepsis using 2-D and M-mode echocardiography...
December 2015: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/26566443/a-review-of-sepsis-induced-cardiomyopathy
#16
REVIEW
Ryota Sato, Michitaka Nasu
Sepsis-induced cardiomyopathy is a reversible myocardial dysfunction that typically resolves in 7-10 days. It is characterized by left ventricular dilatation and depressed ejection fraction. However, many uncertainties exist regarding the mechanisms, characteristics, and treatments of this condition. Therefore, this review attempts to summarize our current knowledge of sepsis-induced cardiomyopathy.
2015: Journal of Intensive Care
https://www.readbyqxmd.com/read/26558621/non-adrenergic-vasopressors-in-patients-with-or-at-risk-for-vasodilatory-shock-a-systematic-review-and-meta-analysis-of-randomized-trials
#17
REVIEW
Alessandro Belletti, Mario Musu, Simona Silvetti, Omar Saleh, Laura Pasin, Fabrizio Monaco, Ludhmila A Hajjar, Evgeny Fominskiy, Gabriele Finco, Alberto Zangrillo, Giovanni Landoni
INTRODUCTION: Hypotensive state is frequently observed in several critical conditions. If an adequate mean arterial pressure is not promptly restored, insufficient tissue perfusion and organ dysfunction may develop. Fluids and catecholamines are the cornerstone of critical hypotensive states management. Catecholamines side effects such as increased myocardial oxygen consumption and development of arrhythmias are well known. Thus, in recent years, interest in catecholamine-sparing agents such as vasopressin, terlipressin and methylene blue has increased; however, few randomized trials, mostly with small sample sizes, have been performed...
2015: PloS One
https://www.readbyqxmd.com/read/26486084/the-activation-of-egfr-promotes-myocardial-tumor-necrosis-factor-%C3%AE-production-and-cardiac-failure-in-endotoxemia
#18
Xuegang Sun, Jiani Liang, Xueqing Yao, Chunhua Lu, Tianyu Zhong, Xiaoyang Hong, Xiaofei Wang, Wenjuan Xu, Miaoning Gu, Jing Tang
To study the effect of EGFR activation on the generation of TNF-α and the occurrence of cardiac dysfuncetion during sepsis, PD168393 and erlotinib (both are EGFR inhibitors) were applied to decreased the production of TNF-α and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes. These results were further proved by specifically knocked down the expression of EGFR in vitro. Both TAPI-1, a TNF-α converting enzyme (TACE) inhibitor, and TGF-α neutralizing antibody could inhibit the activation of EGFR and the generation of TNF-α mRNA after LPS treatment...
November 3, 2015: Oncotarget
https://www.readbyqxmd.com/read/26300484/blockade-of-exosome-generation-with-gw4869-dampens-the-sepsis-induced-inflammation-and-cardiac-dysfunction
#19
Kobina Essandoh, Liwang Yang, Xiaohong Wang, Wei Huang, Dongze Qin, Jiukuan Hao, Yigang Wang, Basilia Zingarelli, Tianqing Peng, Guo-Chang Fan
Sepsis is an infection-induced severe inflammatory disorder that leads to multiple organ failure. Amongst organs affected, myocardial depression is believed to be a major contributor to septic death. While it has been identified that large amounts of circulating pro-inflammatory cytokines are culprit for triggering cardiac dysfunction in sepsis, the underlying mechanisms remain obscure. Additionally, recent studies have shown that exosomes released from bacteria-infected macrophages are pro-inflammatory. Hence, we examined in this study whether blocking the generation of exosomes would be protective against sepsis-induced inflammatory response and cardiac dysfunction...
November 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26202805/tanshinone-iia-attenuates-cardiac-dysfunction-in-endotoxin-induced-septic-mice-via-inhibition-of-nadph-oxidase-2-related-signaling-pathway
#20
Libing Huang, Man Zheng, Yudi Zhou, Juan Zhu, Minghui Zhu, Feng Zhao, Suyang Cui
Cardiac dysfunction is a critical event during sepsis/septic shock. Tanshinone IIA (TIIA), a compound extracted from herb medicine Danshen, has been shown possessing anti-inflammatory and anti-oxidative properties. It is possible, therefore, that treatment with TIIA may attenuate cardiac dysfunction during sepsis/septic shock through inhibition of inflammation. To test this possibility, we preadministrated C57BL/6 mice with TIIA prior to lipopolysaccharide (LPS) challenge. LPS significantly suppressed left ventricular function as evidenced by decreases in EF% and FS% in mice...
September 2015: International Immunopharmacology
keyword
keyword
106281
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"