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treatment of myocardial dysfunction in sepsis

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https://www.readbyqxmd.com/read/29765498/edaravone-improves-septic-cardiac-function-by-inducing-an-hif-1-%C3%AE-ho-1-pathway
#1
Chao He, Wei Zhang, Suobei Li, Wei Ruan, Junmei Xu, Feng Xiao
Septic myocardial dysfunction remains prevalent and raises mortality rate in patients with sepsis. During sepsis, tissues undergo tremendous oxidative stress which contributes critically to organ dysfunction. Edaravone, a potent radical scavenger, has been proved beneficial in ischemic injuries involving hypoxia-inducible factor- (HIF-) 1, a key regulator of a prominent antioxidative protein heme oxygenase- (HO-) 1. However, its effect in septic myocardial dysfunction remains unclarified. We hypothesized that edaravone may prevent septic myocardial dysfunction by inducing the HIF-1/HO-1 pathway...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29724231/pathophysiology-echocardiographic-evaluation-biomarker-findings-and-prognostic-implications-of-septic-cardiomyopathy-a-review-of-the-literature
#2
REVIEW
Robert R Ehrman, Ashley N Sullivan, Mark J Favot, Robert L Sherwin, Christian A Reynolds, Aiden Abidov, Phillip D Levy
BACKGROUND: Sepsis is a common condition encountered by emergency and critical care physicians, with significant costs, both economic and human. Myocardial dysfunction in sepsis is a well-recognized but poorly understood phenomenon. There is an extensive body of literature on this subject, yet results are conflicting and no objective definition of septic cardiomyopathy exists, representing a critical knowledge gap. OBJECTIVES: In this article, we review the pathophysiology of septic cardiomyopathy, covering the effects of key inflammatory mediators on both the heart and the peripheral vasculature, highlighting the interconnectedness of these two systems...
May 4, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29679702/alamandine-attenuates-sepsis-associated-cardiac-dysfunction-via-inhibiting-mapks-signaling-pathways
#3
Peng Li, Xi-Ru Chen, Fei Xu, Chi Liu, Chang Li, Hui Liu, Hui Wang, Wei Sun, Yan-Hui Sheng, Xiang-Qing Kong
Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Alamandine is an important biologically active peptide in the renin-angiotensin system. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the signaling pathways involved in these events. Experiments were carried out in mice treated with lipopolysaccharide (LPS) or alamandine, and in neonatal rat cardiomyocytes. Alamandine increased the ejection fraction and fractional shortening, both of which were decreased upon LPS infusion in mice...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29655602/overexpression-of-ctrp3-protects-against-sepsis-induced-myocardial-dysfunction-in-mice
#4
Wen-Ying Wei, Zhen-Guo Ma, Ning Zhang, Si-Chi Xu, Yu-Pei Yuan, Xiao-Feng Zeng, Qi-Zhu Tang
C1q/tumor necrosis factor-related protein-3 (CTRP3) shows striking homologies of genomic structure to the adiponectin. In this study, we aimed to investigate the protective role of CTRP3 against sepsis-induced cardiomyopathy. Here, we overexpressed CTRP3 in myocardium by direct intramyocardial injection and constructed a model of lipopolysaccharide (LPS)-induced sepsis in mice. Our results demonstrated that cardiac-specific overexpression of CTRP3 remarkably attenuated myocardial dysfunction and increased the phosphorylation level of AMPKα during LPS-induced sepsis...
April 12, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29595686/risk-factors-and-outcomes-of-sepsis-induced-myocardial-dysfunction-and-stress-induced-cardiomyopathy-in-sepsis-or-septic-shock-a-comparative-retrospective-study
#5
COMPARATIVE STUDY
Han Saem Jeong, Tae Hyub Lee, Cho Hee Bang, Jong-Ho Kim, Soon Jun Hong
While both sepsis-induced myocardial dysfunction (SIMD) and stress-induced cardiomyopathy (SICMP) are common in patients with sepsis, the pathogenesis of the 2 diseases is different, and they require different treatment strategies. Thus, we aimed to investigate risk factors and outcomes between the 2 diseases.This retrospective study enrolled patients diagnosed with sepsis or septic shock, admitted to intensive care unit via emergency department in Korea University Anam Hospital, and who underwent transthoracic echocardiography within the first 24 hours of admission...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29549730/ziziphus-spina-christi-l-leaf-extract-alleviates-myocardial-and-renal-dysfunction-associated-with-sepsis-in-mice
#6
Mohamed A Dkhil, Rami B Kassab, Saleh Al-Quraishy, Mohamed M Abdel-Daim, Rafat Zrieq, Ahmed E Abdel Moneim
Ziziphus spina-christi (L.), a traditional Arabian medicinal herb, has been used by Egyptians (Bedouin and Nubian) to treat inflammatory symptoms and swellings, pain, and heat since long. We aimed to investigate whether Ziziphus spina-christi leaf extract (ZSCLE) exerted a myocardial and renal protective effect on mice in which sepsis had been induced with cecal ligation and puncture (CLP). Male C57BL/6 mice were divided randomly into six groups (n = 7): sham-operated group, sham-operated mice treated with ZSCLE (300 mg/kg), CLP-induced sepsis group, ZSCLE (100 mg/kg)-treated group, ZSCLE (200 mg/kg)-treated group, and ZSCLE (300 mg/kg)-treated group...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29540208/exosomes-from-patients-with-septic-shock-convey-mirnas-related-to-inflammation-and-cell-cycle-regulation-new-signaling-pathways-in-sepsis
#7
Juliana Monte Real, Ludmila Rodrigues Pinto Ferreira, Gustavo Henrique Esteves, Fernanda Christtanini Koyama, Marcos Vinícius Salles Dias, João Evangelista Bezerra-Neto, Edécio Cunha-Neto, Flavia Ribeiro Machado, Reinaldo Salomão, Luciano Cesar Pontes Azevedo
BACKGROUND: Exosomes isolated from plasma of patients with sepsis may induce vascular apoptosis and myocardial dysfunction by mechanisms related to inflammation and oxidative stress. Despite previous studies demonstrating that these vesicles contain genetic material related to cellular communication, their molecular cargo during sepsis is relatively unknown. In this study, we evaluated the presence of microRNAs (miRNAs) and messenger RNAs (mRNAs) related to inflammatory response and redox metabolism in exosomes of patients with septic shock...
March 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29431472/cytoprotective-and-antioxidant-effects-of-the-red-alga-alsidium-corallinum-against-hydrogen-peroxide-induced-toxicity-in-rat-cardiomyocytes
#8
Hajer Ben Saad, Ibtissem Ben Amara, Nadia Kharrat, Marie-Agnès Giroux-Metgès, Ahmed Hakim, Khaled Mounir Zeghal, Hélène Talarmin
CONTEXT: Sepsis is the manifestation of the immune and inflammatory responses to infection that may ultimately result in multiorgan failure. Many substances are involved in myocardial dysfunction in sepsis, including hydrogen peroxide. OBJECTIVE: This study evaluates the protective activity of the red alga Alsidium corallinum against hydrogen peroxide (H2 O2 )-induced toxicity in H9c2 cardiomyocytes. MATERIAL AND METHODS: The biological properties of A...
February 12, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29351144/cardiac-dysfunction-in-critical-illness
#9
Allison Dalton, Sajid Shahul
PURPOSE OF REVIEW: Sepsis and septic shock are prevalent conditions that are likely to increase in prevalence in the future. Given the high mortality and morbidity associated with sepsis and sepsis-induced cardiac dysfunction, we must continue to make advances in knowledge of the complex physiologic interactions and how we may target specific mediators for potential therapeutic options in the future. RECENT FINDINGS: Multiple biomarkers have been discovered, which when assayed in sepsis-induced cardiomyopathy predict morbidity and mortality...
April 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29336470/tnf-%C3%AE-induces-drp1-mediated-mitochondrial-fragmentation-during-inflammatory-cardiomyocyte-injury
#10
Yue-Liang Shen, Ying-Zhou Shi, Gai-Ge Chen, Lin-Lin Wang, Ming-Zhi Zheng, Hong-Feng Jin, Ying-Ying Chen
Dynamin-related peptide 1 (Drpl)-mediated mitochondrial fission is an important process associated with cardiac dysfunction under different pathological conditions. The aim of the present study was to investigate the expression of Drpl during inflammatory myocardial injury. Sprague‑Dawley rats were treated intraperitoneally with lipopolysaccharides (LPS). Furthermore, cultured H9C2 cardiomyocytes were treated with LPS, interleukin‑6 (IL‑6) and tumor necrosis factor‑α (TNF‑α). Total and mitochondrial proteins were isolated from the heart tissue of rats and from the H9C2 cardiomyocytes...
April 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29322353/quercetin-exerts-cardiovascular-protective-effects-in-lps-induced-dysfunction-in-vivo-by-regulating-inflammatory-cytokine-expression-nf-%C3%AE%C2%BAb-phosphorylation-and-caspase-activity
#11
Xiqing Wei, Xiangli Meng, Yuxiang Yuan, Fengjuan Shen, Chengqiu Li, Jun Yang
Impaired myocardial contractile function, one of the well-documented features of sepsis, contributes greatly to the high rate of mortality. Quercetin is widely accepted as a potential antioxidant and free radical scavenger. Epidemiologic studies have suggested that an increase in the intake of dietary Quercetin can reduce the risk of cardiac disease. However, presently there is no report yet on the influence of Quercetin on LPS-induced myocardial dysfunction in vivo. Cardiovascular protective effects of Quercetin on LPS-induced sepsis in mice were measured after intragastric administration, using normal saline as a positive control...
January 10, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29214686/myricetin-attenuated-lps-induced-cardiac-injury-in-vivo-and-in-vitro
#12
Nan Zhang, Hong Feng, Hai-Han Liao, Si Chen, Zheng Yang, Wei Deng, Qi-Zhu Tang
Sepsis induced myocardial dysfunction (SIMD) is a common complication and leads to an increased mortality. SIMD is closely related to inflammation and oxidative stress. Myricetin exhibits strong capacities of anti-inflammation and anti-oxidative stress, but its pharmacological effects for lipopolysaccharide (LPS) induced cardiac injury remains undefined. This study aimed to explore whether myricetin was efficient to alleviate SIMD in mice and neonatal rat cardiomyocytes injury. Mice administrated with myricetin (100 mg/kg, po, bid) or vehicle groups were challenged with LPS (10 mg/kg, ip), and cardiac functions examined by echocardiography after 12 hr LPS exposure...
March 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29201378/time-to-re-think-the-use-of-dobutamine-in-sepsis
#13
Ryota Sato, Michitaka Nasu
Dobutamine is commonly used worldwide and included in the protocol for early goal-directed therapy (EGDT). Since the use of dobutamine in EGDT was reported, it has been considered to be an important component, especially in the treatment of septic patients with myocardial dysfunction. However, it is questionable whether dobutamine improves the mortality of sepsis and septic shock. In three recent randomized controlled trials (ProCESS, ProMISe, and ARISE trials), the frequency of dobutamine use was significantly higher in the EGDT group than in the standard care group, but there were no significant differences in the mortality between the groups...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/29127060/granulocyte-colony-stimulating-factor-and-autologous-cd133-positive-stem-cell-therapy-in-liver-cirrhosis-realistic-an-open-label-randomised-controlled-phase-2-trial
#14
Philip Noel Newsome, Richard Fox, Andrew L King, Darren Barton, Nwe-Ni Than, Joanna Moore, Christopher Corbett, Sarah Townsend, James Thomas, Kathy Guo, Diana Hull, Heather A Beard, Jacqui Thompson, Anne Atkinson, Carol Bienek, Neil McGowan, Neil Guha, John Campbell, Dan Hollyman, Deborah Stocken, Christina Yap, Stuart John Forbes
BACKGROUND: Results of small-scale studies have suggested that stem-cell therapy is safe and effective in patients with liver cirrhosis, but no adequately powered randomised controlled trials have been done. We assessed the safety and efficacy of granulocyte colony-stimulating factor (G-CSF) and haemopoietic stem-cell infusions in patients with liver cirrhosis. METHODS: This multicentre, open-label, randomised, controlled phase 2 trial was done in three UK hospitals and recruited patients with compensated liver cirrhosis and MELD scores of 11·0-15·5...
January 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29039314/effects-of-puerarin-on-lipopolysaccharide-induced-myocardial-dysfunction-in-isolated-rat-hearts
#15
Zhang Shaojun, Xu Yanyan, Chen Jian, Zheng Xia, Fang Qiang, Jiang Saiping
Myocardial dysfunction is a serious complication induced by sepsis. Puerarin is an oriental medicine that possesses therapeutic benefits for cardiovascular diseases. The aim of this study was to evaluate the anti-myocardial dysfunction effects of puerarin in isolated rat hearts induced by lipopolysaccharide- and compare the myocardial protective effects between the different concentrations of puerarin. Isolated hearts were attached to a Langendorff apparatus and perfused with lipopolysaccharide (LPS) and different concentrations of puerarin...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28993270/reduced-silent-information-regulator-1-signaling-exacerbates-sepsis-induced-myocardial-injury-and-mitigates-the-protective-effect-of-a-liver-x-receptor-agonist
#16
Dong Han, Xiang Li, Shuang Li, Tao Su, Li Fan, Wen-Si Fan, Hong-Yu Qiao, Jiang-Wei Chen, Miao-Miao Fan, Xiu-Juan Li, Ya-Bin Wang, Sai Ma, Ya Qiu, Zu-Hong Tian, Feng Cao
Myocardial injury and dysfunction are critical manifestations of sepsis. Previous studies have reported that liver X receptor (LXR) activation is protective during sepsis. However, whether LXR activation protects against septic heart injury and its underlying mechanisms remain elusive. This study was designed to determine the role of LXR activation in the septic heart with a focus on SIRT1 (silent information regulator 1) signaling. Male cardiac-specific SIRT1 knockout mice (SIRT1-/-) and their wild-type littermates were subjected to sepsis by cecal ligation and puncture (CLP) in the presence or absence of LXR agonist T0901317...
October 7, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28876709/-management-and-orientation-of-severely-infected-patients-relevance-of-a-%C3%A2-sepsis-fast-track-%C3%A2
#17
André Juillerat, Hari Vivekanantham, Raphaël Burger, Joëlle Hausser, Thierry Fumeaux
Sepsis is a syndrome defined by a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The early recognition of this syndrome in the emergency department (ED) can lead to a better prognosis, when associated with a standardized management focusing on identification of the infectious source, its treatment, and appropriate organ support. Therefore, the implementation of a « Sepsis Fast Track », by analogy with similar protocols regarding stroke or ST-elevated myocardial infarct, deserves interest...
September 6, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28807827/the-endotoxemia-cardiac-dysfunction-is-attenuated-by-ampk-mtor-signaling-pathway-regulating-autophagy
#18
Jie Zhang, Peng Zhao, Nanhu Quan, Lin Wang, Xu Chen, Courtney Cates, Thomas Rousselle, Ji Li
AMP-activated protein kinase (AMPK), an enzyme that plays a role in cellular energy homeostasis, modulates myocardial signaling in the heart. Myocardial dysfunction is a common complication of sepsis. Autophagy is involved in the aging related cardiac dysfunction. However, the role of AMPK in sepsis-induced cardiotoxicity has yet to be clarified, especially in aging. In this study, we explored the role of AMPK in lipopolysaccharide (LPS)-induced myocardial dysfunction and elucidated the potential mechanisms of AMPK/mTOR pathway regulating autophagy in young and aged mice...
October 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28770018/brain-derived-neurotrophic-factor-attenuates-septic-myocardial-dysfunction-via-enos-no-pathway-in-rats
#19
Ni Zeng, Junmei Xu, Weifeng Yao, Suobei Li, Wei Ruan, Feng Xiao
Sepsis-induced myocardial dysfunction increases mortality in sepsis, yet the underlying mechanism is unclear. Brain-derived neurotrophic factor (BDNF) has been found to enhance cardiomyocyte function, but whether BDNF has a beneficial effect against septic myocardial dysfunction is unknown. Septic shock was induced by cecal ligation and puncture (CLP). BDNF was expressed in primary cardiomyocytes, and its expression was significantly reduced after sepsis. In rats with sepsis, a sharp decline in survival was observed after CLP, with significantly reduced cardiac BDNF expression, enhanced myocardial fibrosis, elevated oxidative stress, increased myocardial apoptosis, and decreased endothelial nitric oxide (NO) synthase (eNOS) and NO...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28764841/non-st-elevation-acute-coronary-syndromes-a-comprehensive-review
#20
REVIEW
Tamunoinemi Bob-Manuel, Ikechuckwu Ifedili, Guy Reed, Uzoma N Ibebuogu, Rami N Khouzam
Non-ST elevation-acute coronary syndrome (NSTE-ACS) includes NSTE myocardial infarction and unstable angina. This patient population forms approximately two-thirds of all hospital admissions for ACS in the United States each year and is associated with an in-hospital mortality of 5%. NSTE-ACS is primarily due to an acute change in the supply and demand balance of coronary perfusion and myocardial oxygen consumption, because of the significant coronary artery obstruction presenting as plaque rupture or erosion...
September 2017: Current Problems in Cardiology
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