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treatment of cancer (EORTC) randomised trial 22863

T Van der Kwast, N Al Daoud, L Collette, J Sykes, J Thoms, M Milosevic, R G Bristow, G Van Tienhoven, P Warde, R-O Mirimanoff, M Bolla
AIM: We investigated the prognostic significance of intraductal carcinoma of the prostate (IDC-P) in biopsies and transurethral resections prior to external beam radiotherapy with or without androgen deprivation. METHODS: Cohort 1 consisted of 118 intermediate risk prostate cancer patients treated by radiotherapy, with biochemical relapse as primary end-point (median follow-up 6.5 years). Cohort 2 consisted of 132 high risk patients, enrolled in a phase III randomised trial (EORTC 22863) comparing radiotherapy alone to radiotherapy with long-term androgen deprivation (LTAD) with clinical progression free survival as primary end-point (median follow-up 9...
June 2012: European Journal of Cancer
Fatma Ataman, Alfredo Zurlo, Xavier Artignan, Geertjan van Tienhoven, Leo E Blank, Padraig Warde, Jean B Dubois, Wendy Jeanneret, Frans Keuppens, Jacques Bernier, Abraham Kuten, Laurence Collette, Marianne Pierart, Michel Bolla
Late toxicity and other serious adverse events (SAE) were analysed in the European Organisation for Research and Treatment of Cancer (EORTC) trial 22863. The study evaluated the value of adjuvant endocrine treatment for locally advanced prostate cancer treated with radiotherapy. From 1987 to 1995, 415 patients were randomised. There was long-term toxicity information for 377 patients (91%). Median age was 70 years (range 50-80 years). Median follow-up for late toxicity was 42 months (range 3-136 months). Toxicity was graded according to a modified Radiotherapy and Oncology Group (RTOG) scale...
July 2004: European Journal of Cancer
A Zurlo, L Collette, G van Tienhoven, L Blank, P Warde, J Dubois, W Jeanneret, G Storme, J Bernier, A Kuten, M Pierart, M Bolla
OBJECTIVES: We analysed the acute toxicity observed in the European Organisation for Research and Treatment of Cancer (EORTC) randomised trial 22863 comparing conventional external irradiation with or without an agonist analogue of gonadotropin-releasing hormone in high-risk prostate cancer patients. METHODS: Four hundred five patients that received a dose of at least 30 Gy were considered evaluable for acute toxicity assessment. Toxicity was grouped in a few categories: general, genito-urinary, and lower gastro-intestinal...
August 2002: European Urology
N Neymark, I Adriaenssen, T Gorlia, S Caleo, M Bolla, D Brochon
We present a retrospective cost-effectiveness analysis using data from a randomised controlled trial (EORTC 22863) of the addition of early hormonal therapy with a luteinising hormone-releasing hormone (LHRH) analogue to radiotherapy in the treatment of patients with locally advanced prostate cancer. Data on the use of medical resources were extracted from the hospital charts of 90 patients recruited into the trial by one French hospital. Costs are assessed from the viewpoint of the French healthcare financing system and adjusted for censoring...
September 2001: European Journal of Cancer
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