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https://www.readbyqxmd.com/read/28527283/-frequency-of-helicobacter-pylori-nitroreductase-rdxa-mutations-for-metronidazole-activation-in-a-population-in-the-cauca-department-colombia
#1
Claudia Patricia Acosta, Andrés Javier Quiroga, Carlos H Sierra, Alba Alicia Trespalacios
INTRODUCTION: Resistance to metronidazole is a key factor associated with Helicobacter pylori treatment failure. Even though resistance is mostly associated with RdxA nitroreductase mutations, studies of this H. pylori protein in Popayán (Colombia) are still incipient. OBJECTIVE: To evaluate the frequency of mutations in the RdxA nitroreductase in a population of patients with H. pylori-positive gastrointestinal disease. MATERIALS AND METHODS: We amplified the DNA of 170 gastric biopsies by PCR to detect mutations in the RdxA nitroreductase...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28524341/randomized-controlled-study-of-a-novel-triple-nitazoxanide-ntz-containing-therapeutic-regimen-versus-the-traditional-regimen-for-eradication-of-helicobacter-pylori-infection
#2
Mona Ah Shehata, Raghda Talaat, Samah Soliman, Huda Elmesseri, Shaimaa Soliman, Sherief Abd-Elsalam
BACKGROUND: Helicobacter pylori infection has become more and more resistant to conventional first-line treatment regimens. So, there is a considerable interest in evaluating new antibiotic combinations and regimens. Nitazoxanide is an anti-infective drug with demonstrated activity against protozoa and anaerobic bacteria including H. pylori. This work is designed to evaluate the efficacy and safety of a unique triple nitazoxanide-containing regimen as a treatment regimen in Egyptian patients with H...
May 19, 2017: Helicobacter
https://www.readbyqxmd.com/read/28522904/importance-of-antimicrobial-susceptibility-testing-for-the-management-of-eradication-in-helicobacter-pylori-infection
#3
REVIEW
Nazlı Arslan, Özlem Yılmaz, Ebru Demiray-Gürbüz
The management of Helicobacter pylori (H. pylori) infection treatment differs from the common treatment protocol for other infectious diseases. Because culture- or molecular-guided approaches face several practical issues, such as the invasive procedures required to obtain gastric biopsy specimens and the lack of availability of routine laboratory testing in some places, H. pylori treatment includes the administration of two or three empirically selected antibiotics combined with a proton pump inhibitor rather than evidence-based eradication treatment...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28522798/cut-off-optimization-for-13-c-urea-breath-test-in-a-community-based-trial-by-mathematic-histology-and-serology-approach
#4
Zhe-Xuan Li, Lei-Lei Huang, Cong Liu, Luca Formichella, Yang Zhang, Yu-Mei Wang, Lian Zhang, Jun-Ling Ma, Wei-Dong Liu, Kurt Ulm, Jian-Xi Wang, Lei Zhang, Monther Bajbouj, Ming Li, Michael Vieth, Michael Quante, Tong Zhou, Le-Hua Wang, Stepan Suchanek, Erwin Soutschek, Roland Schmid, Meinhard Classen, Wei-Cheng You, Markus Gerhard, Kai-Feng Pan
The performance of diagnostic tests in intervention trials of Helicobacter pylori (H.pylori) eradication is crucial, since even minor inaccuracies can have major impact. To determine the cut-off point for (13)C-urea breath test ((13)C-UBT) and to assess if it can be further optimized by serologic testing, mathematic modeling, histopathology and serologic validation were applied. A finite mixture model (FMM) was developed in 21,857 subjects, and an independent validation by modified Giemsa staining was conducted in 300 selected subjects...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28516058/comparison-of-amoxicillin-and-metronidazole-effect-on-three-drug-regimen-for-the-treatment-of-helicobacter-pylori-infection-in-children
#5
Karam-Ali Kasiri, Abolfazl Khoshdel, Afshin Karimi, Morteza Sedehi, Niloufar Kasiri
Helicobacter pylori is an important risk factor for chronic gastritis, peptic ulcer, and gastric cancer. Three-drug regimen is the first-line treatment for this infection, but the response rate to treatment varies in different geographical regions. This study was conducted to comparatively determine the effect of amoxicillin and metronidazole on three-drug regimen to treat H. pylori infection in 1-15-year-old children. This clinical trial was conducted on 82 patients aged 1-15 years with convenience sampling referring to the Endoscopy Unit of Hajar Hospital, Shahrekord...
April 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28515219/a-novel-stool-pcr-test-for-helicobacter-pylori-may-predict-clarithromycin-resistance-and-patient-eradication-at-a-high-rate
#6
Erin Beckman, Ilaria Saracino, Giulia Fiorini, Courtney Clark, Vladimir Slepnev, Denise Patel, Clarissa Gomez, Reddy Ponaka, Vecheslav Elagin, Dino Vaira
Objectives: Clarithromycin-based regimens are commonly used as a first line therapy in H. pylori positive patients, however treatment failures are associated with resistance to clarithromycin. The aim of this study was to evaluate the feasibility of using stool samples to detect the presence of H. pylori DNA, while concurrently detecting mutations associated with the resistance to clarithromycin.Methods: Total DNA was extracted from 294 raw stools of H pylori positive and negative patients. TaqMan real-time PCR amplification was used to detect the presence of H...
May 17, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28514409/-new-opportunities-for-the-prevention-of-gastric-cancer
#7
I G Maev, A N Kazyulin
The approvals and provisions of the Management of Helicobacter pylori infection-the Maastricht V/ Florence Consensus Report and those of the Kyoto Global Consensus Conference on H. pylori-associated gastritis, concerning with the primary and secondary prevention of gastric cancer (GC), unambiguously suggest that H. pylori infection is the most important risk factor of GC. Accordingly, the basis for the primary and secondary prevention of GC is the optimization of H. pylori eradication therapy. The clear direct relationship of the risk of GC to the severity and extent of atrophic gastritis, intestinal metaplasia and dysplasia and no reversal of intestinal metaplasia and dysplasia in the presence of H...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28513523/the-efficacy-of-sequential-therapy-in-eradication-of-helicobacter-pylori-in-turkey
#8
F Harmandar, S U İlikhan, Y Üstüündağn, O Harmandar
BACKGROUND AND AIM: Most of the studies about sequential therapy that have been reported from Turkey were levofloxacin based. We aimed to compare the Helicobacter pylori (H. pylori) eradication rates of standard triple, sequential and quadruple therapies including claritromycin regimes in this study. MATERIALS AND METHODS: A total of 160 patients with dyspeptic symptoms were enrolled to the study. The patients were randomized to four groups of treatment protocols...
May 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28507835/endoscopic-view-of-gastroduodenal-artery-coils-at-the-base-of-duodenal-ulcer-in-case-of-recurrent-massive-upper-gastrointestinal-bleed
#9
Rawaa Ebrahem, Salam Kadhem, John W Frey, William Salyers
Helicobacter pylori (H. pylori) infection is one of the major causes of bleeding peptic ulcer disease, which is associated with serious complications; therefore, the eradication of H. pylori is essential to prevent these devastating complications. Post-treatment follow-up is crucial to guarantee the eradication of the organism and may be conducted via the urea breath test, the stool antigen test, or a gastric biopsy. Acute massive upper gastrointestinal (UGI) bleeding is one of the most common complications of peptic ulcer disease...
April 13, 2017: Curēus
https://www.readbyqxmd.com/read/28506722/primary-helicobacter-pylori-resistance-in-elderly-patients-over-20-years-a-bulgarian-study
#10
Lyudmila Boyanova, Galina Gergova, Rumyana Markovska, Nayden Kandilarov, Lyubomir Davidkov, Zoya Spassova, Ivan Mitov
We evaluated the antibiotic susceptibility of 233 Helicobacter pylori strains isolated in the period 2011-2016, involving 62 strains from elderly patients aged 66-93years and 171 strains from younger adults. To assess resistance evolution, primary resistance rates in 92 strains from as many patients aged ≥60years in 1996-2003 were compared with those in 85 strains from infected patients in the same age group in 2011-2016. In the patients aged >65years evaluated during the last 6 years, amoxicillin resistance according to EUCAST and prior breakpoints was 1...
May 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28505287/anti-helicobacter-pylori-activity-of-non-living-heat-killed-form-of-lactobacilli-including-lactobacillus-johnsonii-no-1088
#11
Yuji Aiba, Hiroki Ishikawa, Masayoshi Tokunaga, Yasuhiko Komatsu
Some strains of lactic acid bacteria are reported to inhibit the growth of Helicobacter pylori (H. pylori) and proposed to be useful to support so-called triple therapy for H. pylori. Although most strains must be alive to exert their anti-H. pylori activity, some lactobacilli strains are effective even when dead. One possible underlying mechanism of such an activity of non-living lactobacilli is reportedly co-aggregation with H. pylori. In the present study, we found that a non-living heat-killed form of Lactobacillus johnsonii No...
May 15, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28498343/anti-helicobacter-pylori-activity-of-isocoumarin-paepalantine-morphological-and-molecular-docking-analysis
#12
João Paulo L Damasceno, Ricardo P Rodrigues, Rita de Cássia R Gonçalves, Rodrigo R Kitagawa
The Helicobacterpylori bacterium is one of the main causes of chronic gastritis, peptic ulcers, and even gastric cancer. It affects an average of half of the world population. Its difficult eradication depends upon multi-drug therapy. Since its classification as a group 1 carcinogenic by International Agency for Research on Cancer (IARC), the importance of H. pylori eradication has obtained a novel meaning. There is considerable interest in alternative therapies for the eradication of H. pylori using compounds from a wide range of natural products...
May 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28497487/systematic-review-with-meta-analysis-the-efficacy-of-vonoprazan-based-triple-therapy-on-helicobacter-pylori-eradication
#13
REVIEW
Y S Jung, E H Kim, C H Park
BACKGROUND: In order to increase eradication rates, vonoprazan, a novel potassium-competitive acid blocker, has been used in Helicobacter pylori eradication therapy. AIM: To summarise the results of the efficacy of vonoprazan-based triple therapy, helping clinicians to better understand the benefit of vonoprazan in the treatment of H. pylori infection. METHODS: We conducted a systematic literature search on MEDLINE, EMBASE, and the Cochrane Library using the primary keywords "vonoprazan," "takecab", "TAK-438," "potassium," "competitive," "potassium-competitive," "Helicobacter," and "pylori...
May 12, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28493953/the-association-between-vaca-or-caga-status-and-eradication-outcome-of-helicobacter-pylori-infection-a-meta-analysis
#14
Dan Wang, Qiuping Li, Yuehua Gong, Yuan Yuan
BACKGROUND: H. pylori virulence factors, especially vacA and cagA are important in gastroduodenal disease pathogenesis and affect cure rates. This meta-analysis aimed to clarify the association between vacA or cagA status and eradication outcome of H. pylori infection. METHODS: A literature search was performed using electronic databases to identify studies. Twenty-six prospective studies were determined eligible. Meta-analytical techniques were conducted to calculate eradication rates and pooled relative ratios (RR)...
2017: PloS One
https://www.readbyqxmd.com/read/28493185/dietary-pufa-increase-apoptosis-in-stomach-of-patients-with-dyspeptic-symptoms-and-infected-with-h-pylori
#15
Rasoul Sharifi, Mohammad Nouri, Akram Eidi, Zahra Noormohammadi, Homayun Dolatkhah, Masoud Shirmohammadi
Drug-resistant strains of Helicobacter pylori and poor treatment response are the main reasons for the failure in eradicating it in patients. Polyunsaturated fatty acids (PUFA) have an inhibitory effect on bacterial growth. The aim of this study was to investigate the effect of PUFA in combination with standard triple therapy on apoptosis in H. pylori infected subjects with dyspeptic symptoms. This study was a double-blind clinical trial in which 34 H. pylori infected subjects with dyspeptic symptoms were randomly divided into two groups of 17 patients...
May 10, 2017: Lipids
https://www.readbyqxmd.com/read/28492711/curcumin-in-combination-with-triple-therapy-regimes-ameliorates-oxidative-stress-and-histopathologic-changes-in-chronic-gastritis-associated-helicobacter-pylori-infection
#16
Arezu Judaki, Asghar Rahmani, Jalil Feizi, Khairollah Asadollahi, Mohammad Reza Hafezi Ahmadi
BACKGROUND: Helicobacter pylori (H. pylori) gastric infection is a main cause of inflammatory changes and gastric cancers. OBJECTIVE: The aim of this study was finding the effects of curcumin on oxidative stress and histological changes in chronic gastritis associated with H. pylori. METHODS: In a randomized clinical trial, patients were divided into two groups: a standard triple therapy group and triple therapy with curcumin group. Endoscopic and histological examinations were measured for all patients before and after 8 weeks...
May 8, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28488117/fusion-expression-of-the-pgla-am1-with-native-structure-and-evaluation-of-its-anti-helicobacter-pylori-activity
#17
Xiaolin Zhang, Anmin Jiang, Guisheng Wang, Hao Yu, Banghua Qi, Youyi Xiong, Guoliang Zhou, Meisong Qin, Jinfeng Dou, Jianfei Wang
Helicobacter pylori (H. pylori) shows increasingly enhanced resistance to various antibiotics, and its eradication has become a major problem in medicine. The antimicrobial peptide PGLa-AM1 is a short peptide with 22 amino acids and exhibits strong antibacterial activity. In this study, we investigated whether it has anti-H. pylori activity for the further development of anti-H. pylori drugs to replace existing antibiotics. However, the natural antimicrobial peptide PGLa-AM1 shows a low yield and is difficult to separate, limiting its application...
May 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28473630/epidermal-growth-factor-receptor-inhibition-downregulates-helicobacter-pylori-induced-epithelial-inflammatory-responses-dna-damage-and-gastric-carcinogenesis
#18
Johanna C Sierra, Mohammad Asim, Thomas G Verriere, M Blanca Piazuelo, Giovanni Suarez, Judith Romero-Gallo, Alberto G Delgado, Lydia E Wroblewski, Daniel P Barry, Richard M Peek, Alain P Gobert, Keith T Wilson
OBJECTIVE: Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our goal was to determine the role of EGFR activation in gastric carcinogenesis. DESIGN: We evaluated gefitinib, a specific EGFR inhibitor, in chemoprevention of H...
May 4, 2017: Gut
https://www.readbyqxmd.com/read/28469125/mucosa-associated-lymphoid-tissue-malt-lymphoma-of-the-colon-a-case-report-and-a-literature-review
#19
Hafsa Abbas, Masooma Niazi, Jasbir Makker
BACKGROUND Non-Hodgkin lymphoma (NHL) is a well-known hematologic malignancy. The gastrointestinal (GI) tract is the most commonly involved extra nodal site. MALT lymphomas are uncommon, accounting for 5% of all NHL. Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is the prototype seen in association with Helicobacter pylori. Colonic MALT lymphoma is rare and comprises only 2.5% of the MALT lymphomas. Its etiology and treatment is not well established.  CASE REPORT A 56-year-old Hispanic woman presented to the clinic with symptoms of chronic epigastric pain for the past three years and a 13-pound weight loss over the past two months...
May 4, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28465629/noninvasive-molecular-analysis-of-helicobacter-pylori-is-it-time-for-tailored-first-line-therapy
#20
EDITORIAL
Enzo Ierardi, Floriana Giorgio, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Antonio Pisani, Alfredo Di Leo
The main problem of Helicobacter pylori (H. pylori) infection management is linked to antibiotic resistances. This phenomenon has grown in the last decade, inducing a dramatic decline in conventional regimen effectiveness. The causes of resistance are point mutations in bacterial DNA, which interfere with antibiotic mechanism of action, especially clarithromycin and levofloxacin. Therefore, international guidelines have recently discouraged their use in areas with a relevant resistance percentage, suggesting first-line schedules with expected high eradication rates, i...
April 14, 2017: World Journal of Gastroenterology: WJG
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