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eradication of h. pylori

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https://www.readbyqxmd.com/read/28807915/both-14-day-hybrid-and-bismuth-quadruple-therapies-cure-most-patients-with-helicobacter-pylori-infection-in-populations-with-moderate-antibiotic-resistance-a-randomized-controlled-trial
#1
Feng-Woei Tsay, Deng-Chyang Wu, Hsien-Chung Yu, Sung-Shuo Kao, Kung-Hung Lin, Jin-Shiung Cheng, Huay-Min Wang, Wen-Chi Chen, Wei-Chih Sun, Kuo-Wang Tsai, Ping-I Hsu
BACKGROUND & AIM: Hybrid therapy is a novel two-step treatment achieving a high eradication rate for H. pylori infection. Currently, whether this new therapy achieves a higher eradication rate than bismuth quadruple therapy remains an unanswered question. The aim of this prospective, randomized, comparive study was to investigate the efficacies of 14-day hybrid therapy and bismuth quadruple therapy in the treatment of H. pylori infection.METHODS: From July 2013 to June 2015, eligible H. pylori-infected subjects were randomly assigned to receive either 14-day bismuth quadruple therapy (pantoprazole, bismuth subcitrate, tetracycline, and metronidazole for 14 days) or 14-day hybrid therapy (a 7-day dual therapy with pantoprazole plus amoxicillin, followed by a 7-day quadraple therapy with pantoprazole plus amoxicillin, clarithromycin and metronidazole)...
August 14, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28806959/second-line-therapy-for-helicobacter-pylori-eradication-causing-antibiotic-associated-hemorrhagic-colitis
#2
Kazuyuki Tanaka, Mikihiro Fujiya, Aki Sakatani, Shugo Fujibayashi, Yoshiki Nomura, Nobuhiro Ueno, Shin Kashima, Takuma Goto, Junpei Sasajima, Kentaro Moriichi, Toshikatsu Okumura
OBJECTIVE: Helicobacter pylori (H. pylori) eradication rarely develops into antibiotic-associated hemorrhagic colitis (AAHC), in which the etiology of colitis remains unclear. We herein report a rare case of AAHC caused by second-line therapy for H. pylori eradication. RESULTS: A 65-year-old female was administered second-line therapy for H. pylori composed of 1500 mg of amoxicillin, 500 mg of metronidazole and 40 mg of vonoprazan for 7 days because of first-line therapy failure...
August 14, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28801429/multicentric-randomised-study-of-helicobacter-pylori-eradication-and-pepsinogen-testing-for-prevention-of-gastric-cancer-mortality-the-gistar-study
#3
Marcis Leja, Jin Young Park, Raul Murillo, Inta Liepniece-Karele, Sergejs Isajevs, Ilze Kikuste, Dace Rudzite, Petra Krike, Sergei Parshutin, Inese Polaka, Arnis Kirsners, Daiga Santare, Valdis Folkmanis, Ilva Daugule, Martyn Plummer, Rolando Herrero
INTRODUCTION: Population-based eradication of Helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. However, the potential adverse effects of widespread antibiotic use that this would entail have not been sufficiently studied. An alternative way to decrease gastric cancer mortality is by non-invasive search for precancerous lesions, in particular gastric atrophy; pepsinogen tests are the best currently available alternative. The primary objective of GISTAR is to determine whether H pylori eradication combined with pepsinogen testing reduces mortality from gastric cancer among 40-64-year-old individuals...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799258/helicobacter-pylori-infection-and-serum-level-of-pepsinogen-are-associated-with-the-risk-of-metachronous-gastric-neoplasm-after-endoscopic-resection
#4
Y Kwon, S Jeon, S Nam, I Shin
BACKGROUND: Patients who have undergone endoscopic resection of early gastric cancers (EGCs) are at risk for metachronous gastric neoplasm. AIM: To determine whether serum level of pepsinogen (PG), a marker of gastric atrophy, can determine which patients who have undergone endoscopic submucosal dissection for EGC are at risk for metachronous gastric neoplasm. We also investigated the effects of Helicobacter pylori eradication on metachronous gastric neoplasm incidence...
August 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28796053/berberine-containing-quadruple-therapy-for-initial-helicobacter-pylori-eradication-an-open-label-randomized-phase-iv-trial
#5
Di Zhang, Li Ke, Zhen Ni, Yu Chen, Lin-Hui Zhang, Shao-Hua Zhu, Chan-Juan Li, Lei Shang, Jie Liang, Yong-Quan Shi
BACKGROUND: Due to increasing antimicrobial resistance, a bismuth-based quadruple regimen has been recommended as an alternative first-line therapy for Helicobacter pylori (H pylori) eradication. However, different results are varied greatly and the availability of bismuth was limited in some countries. We assessed the efficacy and safety of 14-day berberine-containing quadruple therapy as an alternative regimen for H pylori eradication. METHODS: In a randomized, open-label, non-inferiority, phase IV trial between November 25, 2014, and October 15, 2015, 612 treatment-naive patients were randomly assigned to 14-day berberine-containing (n = 308) or 14-day bismuth-containing (n = 304) quadruple therapy...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28792967/aminophosphinates-against-helicobacter-pylori-ureolysis-biochemical-and-whole-cell-inhibition-characteristics
#6
Katarzyna Macegoniuk, Ewa Grela, Monika Biernat, Mateusz Psurski, Grażyna Gościniak, Anna Dziełak, Artur Mucha, Joanna Wietrzyk, Łukasz Berlicki, Agnieszka Grabowiecka
Urease is an important virulence factor from Helicobacter pylori that enables bacterial colonization of human gastric mucosa. Specific inhibition of urease activity can be regarded as a promising adjuvant strategy for eradication of this pathogen. A group of organophosphorus inhibitors of urease, namely, aminophosphinic acid and aminophosphonic acid derivatives, were evaluated in vitro against H. pylori urease. The kinetic characteristics of recombinant enzyme activity demonstrated a competitive reversible mode of inhibition with Ki values ranging from 0...
2017: PloS One
https://www.readbyqxmd.com/read/28791844/frequency-of-infection-with-helicobacter-pylori-isolates-of-different-antimicrobial-profiles-in-children-and-adolescents-a-preliminary-study
#7
Grażyna Gościniak, Monika M Biernat, Aldona Bińkowska, Agnieszka Kus, Barbara Iwańczak
BACKGROUND: Helicobacter pylori (H. pylori) infection can occur as a mixed infection caused by several strains of H. pylori. OBJECTIVES: The aim of the study was to determine the frequency of colonization of the gastric mucosa by strains of H. pylori with different susceptibility to antimicrobial agents. MATERIAL AND METHODS: The study was carried out on gastric biopsies taken from 54 previously untreated Polish children and adolescents. Of the 15 positive cultures, from each primary medium, 6 single H...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28791813/an-evaluation-of-selected-oral-health-indicators-and-cariogenic-bacteria-titer-in-patients-with-helicobacter-pylori
#8
Jakub Urban, Rafał Koszowski, Anna Płachetka, Andrzej Wiczkowski
BACKGROUND: Studies based on polymerase chain reaction (PCR) techniques indicate that Helicobacter pylori can be constantly or temporarily present in the oral cavity in virulent or non-virulent form. Streptococcus mutans exerts a strong inhibitory effect on H. pylori. OBJECTIVES: The aim of the present study was to investigate the prevalence and virulence of H. pylori in the oral cavity and the correlation of these factors with oral health and cariogenic bacteria titer...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28781119/primary-antibiotic-resistance-in-helicobacter-pylori-in-the-asia-pacific-region-a-systematic-review-and-meta-analysis
#9
Yu-Ting Kuo, Jyh-Ming Liou, Emad M El-Omar, Jeng-Yih Wu, Alex Hwong Ruey Leow, Khean Lee Goh, Rajashree Das, Hong Lu, Jaw-Town Lin, Yu-Kang Tu, Yoshio Yamaoka, Ming-Shiang Wu
BACKGROUND: So far, a comprehensive systematic review and meta-analysis has not been done of the prevalence of primary antibiotic resistance in Helicobacter pylori in the Asia-Pacific region. We aimed to assess the trends and regional differences in primary antibiotic resistance to H pylori in the Asia-Pacific region and to examine the relation between resistance and first-line eradication. METHODS: We did a systematic review and meta-analysis of primary antibiotic resistance to H pylori and the efficacy of first-line regimens in the Asia-Pacific region...
August 3, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28780968/efficacy-and-safety-of-rifaximin-associated-with-standard-triple-therapy-omeprazole-clarithromycin-and-amoxicillin-for-h-pylori-eradication-a-phase-iv-pilot-clinical-trial
#10
Mercedes Ramas, Maria G Donday, Adrian G McNicholl, Javier P Gisbert
BACKGROUND: A progressive decrease in Helicobacter pylori eradication rates has been described over the years, driving the need for new antibiotic treatments. AIM: To evaluate the efficacy and safety of the addition of rifaximin (Spiraxin(®)) to standard triple therapy (omeprazole, amoxicillin and clarithromycin) for the eradication of H. pylori. METHODS: Independent prospective clinical trial (EUDRACT no.: 2013-001080-23). Forty consecutive adult patients were included with H...
August 3, 2017: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/28780229/the-effects-of-helicobacter-pylori-eradication-on-modification-of-metabolic-syndrome-parameters-in-patients-with-functional-dyspepsia
#11
Marjan Mokhtare, Hosna Mirfakhraee, Mahmoud Arshad, Seyed Hossein Samadani Fard, Mansour Bahardoust, Alireza Movahed, Mohsen Masoodi
BACKGROUND: Helicobactor pylori (H. pylori) have the potential role in the pathogenesis of various extra-gastric disorders such as metabolic disorders. But, it is now questioned about whether H. pylori eradication reduces or induces the risk for metabolic disorders especially in patients with dyspepsia. Hence, the present study aimed to assess the effects of H. pylori eradication on criteria of metabolic syndrome. METHODS: H. pylori infected patients with dyspepsia were included...
July 27, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28771894/effect-on-helicobacter-pylori-eradication-therapy-against-gastric-cancer-in-japan
#12
Momoko Tsuda, Masahiro Asaka, Mototsugu Kato, Rumiko Matsushima, Kenji Fujimori, Kozo Akino, Shogo Kikuchi, Yingsong Lin, Naoya Sakamoto
BACKGROUND: In Japan, there have been approximately 50 000 deaths from gastric cancer annually for over 40 years with little variation. It has been reported that most gastric cancers in Japan are caused by Helicobacter pylori infection. H. pylori eradication therapy was approved for patients with chronic gastritis by the Japanese national health insurance scheme in February 2013 for patients with an endoscopic diagnosis of chronic gastritis is positive for H. pylori. We examined the effect on gastric cancer death rate 4 years after expansion of health insurance coverage...
August 3, 2017: Helicobacter
https://www.readbyqxmd.com/read/28771880/limited-effectiveness-with-a-10-day-bismuth-containing-quadruple-therapy-pylera-%C3%A2-in-third-line-recue-treatment-for-helicobacter-pylori-infection-a-real-life-multicenter-study
#13
Enrique Rodríguez de Santiago, Carlos Martín de Argila de Prados, Hector Miguel Marcos Prieto, Miguel Ãngel Jorge Turrión, Eva Barreiro Alonso, Alvaro Flores de Miguel, Cristobal de la Coba Ortiz, Carlos Rodríguez Escaja, Gustavo Pérez Álvarez, Carlos Ferre Aracil, Lara Aguilera Castro, Ana García García de Paredes, Antonio Rodríguez Pérez, Agustin Albillos Martínez
BACKGROUND: Helicobacter pylori antibiotic resistance is an increasing problem worldwide. Pylera(®) may be an option as salvage therapy. AIM: To assess the effectiveness, safety, and tolerance of Pylera(®) as a third-line in clinical practice. MATERIALS AND METHODS: This was a multicenter, observational, prospective database study in four Spanish hospitals. Consecutive H. pylori-infected individuals treated with Pylera(®) and a proton-pump inhibitor (PPI) were invited to participate if they had failed to respond to PPI-clarithromycin-amoxicillin as first-line and to levofloxacin-amoxicillin-PPI as second-line therapy...
August 3, 2017: Helicobacter
https://www.readbyqxmd.com/read/28771198/prevention-of-gastric-cancer-eradication-of-helicobacter-pylori-and-beyond
#14
REVIEW
Tetsuya Tsukamoto, Mitsuru Nakagawa, Yuka Kiriyama, Takeshi Toyoda, Xueyuan Cao
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28762251/h-pylori-management-in-asean-the-bangkok-consensus-report
#15
REVIEW
Varocha Mahachai, Ratha-Korn Vilaichone, Rapat Pittayanon, Jarin Rojborwonwitaya, Somchai Leelakusolvong, Monthira Maneerattanaporn, Peranart Chotivitayatarakorn, Sombat Treeprasertsuk, Chomsri Kositchaiwat, Pises Pisespongsa, Pisaln Mairiang, Aziz Rani, Alex Leow, Swe Mon Mya, Yi-Chia Lee, Sengdao Vannarath, Bouachanh Rasachak, Oung Chakravuth, Moe Myint Aung, Tiing-Leong Ang, Jose D Sollano, Duc Quach Trong, Inchaya Sansak, Olarn Wiwattanachang, Piyathida Harnsomburana, Ari Fahrial Syam, Yoshio Yamaoka, Kwong-Ming Fock, Khean-Lee Goh, Kentaro Sugano, David Graham
Helicobacter pylori (H. pylori) infection remains to be the major cause of important upper gastrointestinal diseases such as chronic gastritis, peptic ulcer, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. H. pylori management in ASEAN: the Bangkok consensus report gathered key opinion leaders for the region to review and evaluate clinical aspects of H. pylori infection and to develop consensus statements, rationales and grades of recommendation for the management of H. pylori infection in clinical practice in ASEAN countries...
July 31, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28760790/impact-of-health-insurance-coverage-for-helicobacter-pylori-gastritis-on-the-trends-in-eradication-therapy-in-japan-retrospective-observational-study-and-simulation-study-based-on-real-world-data
#16
Shinzo Hiroi, Kentaro Sugano, Shiro Tanaka, Koji Kawakami
OBJECTIVES: To explore the prevalence of Helicobacter pylori infection in Japan and the trends of its eradication therapy before and after the changes of the insurance coverage policy, first started in 2000, and expanded to cover H. pylori-positive gastritis in 2013. The impacts that the changes brought were estimated. METHODS: In this retrospective observational study and simulation study based on health insurance claims data, product sales data and relevant studies, individuals who received triple therapy (amoxicillin, clarithromycin, proton-pump inhibitors or potassium-competitive acid blockers) were defined as the first-time patients for H...
July 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28752210/helicobacter-pylori-infection-and-atherosclerosis-is-there-a-causal-relationship
#17
REVIEW
Z Xu, J Li, H Wang, G Xu
For many years, the coexistence of Helicobacter pylori (H. pylori) infection and atherosclerotic diseases in a disproportional number of patients has inspired the presumption that a causal relationship exists between the conditions. This presumption was evidenced by the simultaneously declining epidemics of duodenal ulcer and coronary artery diseases in the United States in the past 40 years, and was further evidenced by the detection of H. pylori and their DNA in atherosclerotic plaques. Suggested mechanisms underlying this possible causality include intensified inflammatory stress, dyslipidemia, abnormal glucose metabolism, arterial stiffness, increased blood pressure and malnutrition...
July 27, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28748532/rdxa-frxa-and-efflux-pump-in-metronidazole-resistant-helicobacter-pylori-their-relation-to-clinical-outcomes
#18
Sun Min, Nayoung Kim, Yong Hwan Kwon, Ryoung Hee, Jung Mogg Kim, Jong Youn, Yeon Suk Lee, Dong Ho Lee
BACKGROUND AND AIM: rdxA and frxA mutations and enhancement of efflux pump have been suggested as the cause of metronidazole resistance in Helicobacter pylori. This study was performed to investigate the resistance mechanisms related to clinical eradication outcome, and to examine direct involvement of hefA in metronidazole-resistant isolates with intact rdxA and frxA. METHODS: A total of 53 H. pylori-positive patients who were treated with metronidazole-containing sequential or quadruple therapy from 2011 to 2015 were enrolled...
July 27, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28732793/characterization-of-clarithromycin-resistant-helicobacter-pylori-strains-in-iran-a-systematic-review-and-meta-analysis
#19
REVIEW
Farzad Khademi, Amir Hossein Sahebkar, Hamid Vaez, Mohsen Arzanlou, Hadi Peeridogaheh
BACKGROUND: The high prevalence of clarithromycin-resistant strains of Helicobacter pylori is a main challenge for the successful treatment of gastrointestinal infections. Point mutations in the 23S rRNA gene are one of the main mechanisms leading to the resistance to clarithromycin in Iran. The purpose of the present review was to evaluate the prevalence of clarithromycin-resistant H. pylori strains in Iran and to identify the major molecular mechanisms of resistance in the resistant isolates...
July 18, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28730504/changing-trends-in-stomach-cancer-throughout-the-world
#20
REVIEW
Maya Balakrishnan, Rollin George, Ashish Sharma, David Y Graham
PURPOSE OF REVIEW: The paper aims to discuss the global trends in gastric cancer incidence in relation to important factors involved in the pathogenesis of gastric cancer. RECENT FINDINGS: Despite a significant worldwide decline, gastric cancer remains a common cause of cancer death. The decline has been multifactorial and preceded the fall in Helicobacter pylori prevalence. The initial decline was associated with changes in food preservation and availability, especially of fresh fruits and vegetables, followed by a decline in the primary etiologic factor, H...
August 2017: Current Gastroenterology Reports
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