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eradication of h. pylori

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https://www.readbyqxmd.com/read/29456644/eudesmin-attenuates-helicobacter-pylori-induced-epithelial-autophagy-and-apoptosis-and-leads-to-eradication-of-h-pylori-infection
#1
Jai-Sing Yang, Chao-Min Wang, Chiu-Hsian Su, Han-Chen Ho, Chiung-Hung Chang, Chang-Hung Chou, Yuan-Man Hsu
Eudesmin has been proven to possess anti-inflammatory effects. In the present study, the effects of eudesmin on Helicobacter pylori (H. pylori) -mediated autophagy, apoptosis, immune response and inflammation were determined in human gastric adenocarcinoma (AGS) cells in vitro and in C57BL/6 mice in vivo . Detection of the production of interleukin (IL)-8, IL-1β and immunoglobulin M (IgM) was performed using ELISA. Identification of the activation of apoptosis-associated caspase-3, -8 and -9 proteins, Bcl-2-associated X protein (Bax) and BH3 interacting domain death agonist (Bid) protein, was determined through western blot analysis...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29448222/a-colorimetric-broth-microdilution-method-for-assessment-of-helicobacter-pylori-sensitivity-to-antimicrobial-agents
#2
Petar Knezevic, Verica Aleksic Sabo, Natasa Simin, Marija Lesjak, Neda Mimica-Dukic
Helicobacter pylori is a major infective etiological agent of the upper gastrointestinal tract diseases. The bacterium exhibits resistance to various conventional antibiotics, being usually challenging for eradication. Since there is an urge to consider alternative therapeutic strategies, the aim of the study was to examine selected essential oils of plants belonging to families Cupressaceae (Juniperus communis) and Lamiaceae (Hyssopus officinalis, Salvia officinalis, Melissa officinalis, Lavandula angustifolia, Ocimum basilicum and Thymus serpyllum) against H...
February 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29444284/gentamicin-intercalated-smectite-as-a-new-therapeutic-option-for-helicobacter-pylori-eradication
#3
Su Jin Jeong, Jie-Hyun Kim, Da Hyun Jung, Kyoung Hwa Lee, Soon Young Park, Yungoo Song, Il-Mo Kang, Young Goo Song
Objectives: Novel antibacterial strategies against Helicobacter pylori are needed because H. pylori strains are acquiring resistance to antibiotics. We evaluated the efficacy of gentamicin-intercalated smectite hybrid (S-GEN)-based treatment regimens in a murine model of H. pylori infection. Methods: Two groups of 10 rats were administered either smectite or S-GEN to measure coverage of the gastric mucosa. To evaluate anti-H. pylori efficacy, mice were divided into eight groups of 10 mice each given different treatments, and H...
February 12, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29442458/the-influence-of-vitamin-d-deficiency-on-eradication-rates-of-helicobacter-pylori
#4
Oguzhan Yildirim, Tulay Yildirim, Yuksel Seckin, Pelin Osanmaz, Yilmaz Bilgic, Rafet Mete
BACKGROUND: Helicobacter pylori eradication therapy improves the healing of various gastro-duodenal diseases such as chronic gastritis and peptic ulcer, and also reduces gastric cancer incidence. Several studies have reported on risk factors other than antibiotic resistance related to Helicobacter pylori eradication failure. OBJECTIVES: In this study, we aimed to investigate whether or not the serum levels of 25-hydroxy-vitamin D (25(OH)D) influence eradication rates of H...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29430411/comparison-of-efficacy-and-pharmacoeconomics-of-two-helicobacter-pylori-eradication-regimens-in-peptic-ulcer-disease
#5
Syeda Zaineb Kubra Hussaini, Syeda Zaineb Humaira Hussaini, Ruheena Yasmeen, Bader Unnisa, Aamir Ali Asgar Syed, Md Nematullah Khan, Syed Ibrahim Hassan
Background: Helicobacter pylori , the cause of most peptic ulcer diseases, infects approximately 50% of the population worldwide. Indian data on cost and effectiveness of the standard first-line therapies for H. pylori eradication are scarce. Thus, the present study was aimed at comparing the cost and efficacy of two standard first-line therapies: Regimen I comprising pantoprazole (40 mg) plus amoxicillin (750 mg) plus clarithromycin (500 mg) (PAC) and Regimen II comprising rabeprazole (20 mg) plus amoxicillin (625 mg) plus metronidazole (200 mg) (RAM)...
January 2018: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/29428426/first-line-treatment-of-helicobacter-pylori-in-lebanon-comparison-of-bismuth-containing-quadruple-therapy-versus-14-days-sequential-therapy
#6
Mahdi Tarhini, Mohammad Fayyad-Kazan, Hussein Fayyad-Kazan, Mahmoud Mokbel, Mohammad Nasreddine, Bassam Badran, Ghada Kchour
Helicobacter Pylori (H. Pylori) is the most common cause of peptic ulcer disease (PUD) and represents a strong risk factor for gastric cancer. Treatment of H. Pylori is, therefore, a persistent need to avoid serious medical complications. Resistance to antibiotics remains to be the major challenge for H. Pylori eradication. In this study, we determined the prevalence of H. pylori infection and evaluated H. pylori eradication efficacy of bismuth-containing quadruple therapy (Pylera) versus 14-days sequential therapy in treatment naïve-Lebanese patients...
February 8, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29427040/novel-epigenetic-markers-for-gastric-cancer-risk-stratification-in-individuals-after-helicobacter-pylori-eradication
#7
Masahiro Maeda, Satoshi Yamashita, Taichi Shimazu, Naoko Iida, Hideyuki Takeshima, Takeshi Nakajima, Ichiro Oda, Sohachi Nanjo, Chika Kusano, Akiko Mori, Hiroshi Moro, Harumi Yamada, Shoichiro Tsugane, Toshiro Sugiyama, Yoshiharu Sakai, Toshikazu Ushijima
BACKGROUND: The risk stratification of healthy individuals after Helicobacter pylori eradication is an urgent issue. The assessment of aberrant DNA methylation accumulated in gastric tissues with normal appearance, which can reflect overall epigenomic damage, is a promising strategy. We aimed to establish novel epigenetic cancer risk markers for H. pylori-eradicated individuals. METHODS: Gastric mucosa was collected from eight healthy volunteers without H. pylori infection (G1), 75 healthy individuals with gastric atrophy (G2), and 94 gastric cancer patients (G3) after H...
February 9, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29423095/decrease-in-psca-expression-caused-by-helicobacter-pylori-infection-may-promote-progression-to-severe-gastritis
#8
Osamu Toyoshima, Chizu Tanikawa, Ryuta Yamamoto, Hidenobu Watanabe, Hiroharu Yamashita, Kosuke Sakitani, Shuntaro Yoshida, Michiaki Kubo, Keitaro Matsuo, Hidemi Ito, Kazuhiko Koike, Yasuyuki Seto, Koichi Matsuda
SNP rs2294008 in Prostate Stem Cell Antigen (PSCA) and decreased PSCA expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and PSCA expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of H. pylori-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (P = 9.4 × 10-5; odds ratio = 3.88, TT + TC vs CC genotype), but not with H. pylori infection per se nor with the progression from active gastritis to gastric cancer...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29411724/a-prospective-randomized-study-comparing-7-day-and-14-day-quadruple-therapies-as-first-line-treatments-for-helicobacter-pylori-infection-in-patients-with-functional-dyspepsia
#9
A Yagbasan, D Ö Coşkun, Ö Özbakir, K Deniz, Ş Gürsoy, M Yücesoy
OBJECTIVE: Standard triple therapy for Helicobacter pylori has a low eradication rate in Turkey. The aim of this study was to evaluate and compare the effectiveness of 7-day and 14-day lansoprazole, amoxicillin, clarithromycin, and bismuth subsalicylate (LACB) treatment regimens as first-line H. pylori eradication therapies. MATERIALS AND METHODS: This study included 70 patients with symptoms of dyspepsia and a positive H. pylori stool antigen test (SAT). Thirty-five patients received the modified quadruple therapy regimen for 7 days (LACB-7) whereas the remaining 35 patients received the treatment for 14 days (LACB-14)...
January 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29407232/t-cell-subsets-play-an-important-role-in-the-determination-of-the-clinical-outcome-of-helicobacter-pylori-infection
#10
REVIEW
Abdollah Jafarzadeh, Tiziana Larussa, Maryam Nemati, Shila Jalapour
Helicobacter pylori (H. pylori) is one of the most prevalent human pathogen and a persistent infection with this bacterium causes common pathologies, such as gastritis or peptic ulcers, and also less common but more serious pathologies, such as gastric cancer or gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The clinical outcome of gastrointestinal infection sustained by H. pylori is determined by the reciprocal interactions between virulence factors of the bacterium and host factors, including immune response genes...
January 30, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29404268/pilot-study-comparing-efficacy-of-14-day-triple-therapy-clarithromycin-versus-levofloxacin-on-eradication-of-helicobacter-pylori-infection-in-syrian-population-single-center-experience
#11
Khaled Mohammad Cheha, Sawsan Omar Ali Dib, Marouf Mohammad Alhalabi
Context: Goals: To compare the efficacy of standard triple therapy with clarithromycin versus triple therapy with levofloxacin for treatment of Helicobacter pylori-positive infection in a referral hospital in Damascus, Syria. Design: pilot prospective open-label randomized controlled trial. Subjects and Methods: Eighty treatment-naive patients who tested positive for H. pylori gastric infection were randomly assigned to one of two treatment groups with randomization ratio of 50/50...
January 2018: Avicenna Journal of Medicine
https://www.readbyqxmd.com/read/29398507/anti-h-antibody-of-unusually-high-titer-showing-variable-reactivities-against-group-a-red-cells-and-broad-thermal-amplitude-in-a-patient-with-lymphoma
#12
Seung Jun Choi, Hoon Seok Kim, Jaewoong Lee, Young-Sun Song, Jihyang Lim
We report a case of a patient with high titer anti-H antibody showing broad thermal amplitude and variable reactivities against group A red cells. A 62-year-old Korean female was diagnosed with diffuse large B cell lymphoma involving multiple organs. Her ABO/RhD type was A+ and her genotype was ABO*A.01.01/ABO*O.01.02. Antibody screening test (AST) and antibody identification test (IDT) were strongly positive for all reagent cells. Anti-human globulin (AHG) test revealed an antibody titer of 1:256 for 37 °C phase and trace positivity for poly- and mono-specific C3d...
January 3, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29393194/vonoprazan-a-novel-potassium-competitive-acid-blocker-should-be-used-for-the-helicobacter-pylori-eradication-therapy-as-first-choice-a-large-sample-study-of-vonoprazan-in-real-world-compared-with-our-randomized-control-trial-using-second-generation-proton-pump
#13
Haruhiko Ozaki, Satoshi Harada, Toshihisa Takeuchi, Shinpei Kawaguchi, Yoshiaki Takahashi, Yuichi Kojima, Kazuhiro Ota, Yasushi Hongo, Kiyoshi Ashida, Masahiro Sakaguchi, Satoshi Tokioka, Hiroki Sakamoto, Takahisa Furuta, Kazunari Tominaga, Kazuhide Higuchi
BACKGROUND/AIMS: Phase III study demonstrated that vonoprazan-based Helicobacter pylori eradication therapy achieved higher eradication rate compared with lansoprazole. However, there is no study that evaluated the efficacy of vonoprazan in a large sample in real world. We investigated the eradication rate and safety of vonoprazan-based eradication therapy compared with our randomized control trial using second-generation proton pump inhibitor (PPIs). METHODS: (First study) A total of 147 patients who have H...
January 31, 2018: Digestion
https://www.readbyqxmd.com/read/29387204/clinical-manifestations-and-epigenetic-mechanisms-of-gastric-mucosa-associated-lymphoid-tissue-lymphoma-and-long-term-follow-up-following-helicobacter-pylori-eradication
#14
Yan Song, Kui Jiang, Shuai Su, Bangmao Wang, Guangxia Chen
The current study aimed to summarize the clinical manifestations and identify the epigenetic mechanisms of gastric mucosa associated lymphoid tissue (MALT) lymphoma, as well as evaluate the long-term effects of Helicobacter pylori (H. pylori) eradication. A total of 122 patients with marginal zone B-cell lymphoma of primary gastric MALT lymphoma were enrolled in the present study. The clinical manifestations of gastric MALT lymphoma, including symptoms, H. pylori state and endoscopic type, were summarized. The response to therapy was evaluated in patients that underwent H...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29383192/meta-analysis-of-the-correlation-between-helicobacter-pylori-infection-and-autoimmune-thyroid-diseases
#15
Yi Hou, Wen Sun, Chengfei Zhang, Tieshan Wang, Xuan Guo, Lili Wu, Lingling Qin, Tonghua Liu
Objective: This study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD). Materials and Methods: Fifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software. Results: H. pylori infection was positively correlated with the occurrence of AITD (OR = 2...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29382776/helicobacter-pylori-eradication-treatment-and-the-risk-of-gastric-adenocarcinoma-in-a-western-population
#16
Eva Doorakkers, Jesper Lagergren, Lars Engstrand, Nele Brusselaers
OBJECTIVE: Gastric infection with Helicobacter pylori is a strong risk factor for non-cardia gastric adenocarcinoma. The aim of this study was to assess whether the risk of gastric adenocarcinoma and non-cardia gastric adenocarcinoma decreases after eradication treatment for H. pylori in a Western population. DESIGN: This was a nationwide, population-based cohort study in Sweden in 2005-2012. Data from the Swedish Prescribed Drug Registry provided information on H...
January 30, 2018: Gut
https://www.readbyqxmd.com/read/29382601/visual-diagnostic-of-helicobacter-pylori-based-on-a-cascade-amplification-of-pcr-and-g-quadruplex-dnazyme-as-a-color-label
#17
Zhanmin Liu, Chenhui Yao, Yanming Wang, Wenyun Zheng
Helicobacter pylori is a spiral-shaped, Gram-negative, microaerophilic and fastidious bacterium. It is the main cause of chronic gastritis as well as gastric and duodenal ulcers. The diagnosis of H. pylori infection is significant for the selection of therapy and for the follow up of eradication success. A simple and robust strategy based on the cascade of PCR and DNAzyme catalyzed reaction was utilized to detect H. pylori. The design of the primer pair would enable PCR to synthesize aptamer of DNAzyme at the 3' end of PCR products...
January 27, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29370199/meta-analysis-high-dose-vs-low-dose-metronidazole-containing-therapies-for-helicobacter-pylori-eradication-treatment
#18
Yingjie Ji, Hong Lu
OBJECTIVE: The purpose of this study was to evaluate the efficacy of high dose of metronidazole in the treatment of Helicobacter pylori (H. pylori) infection. METHODS: Studies were identified from databases (Pubmed, Embase, Cochrane Library, ClinicalTrials.gov) searched from January 1990 to September 2017 using a battery of keywords. We included randomized controlled trials (RCTs) of H. pylori treatment comparing the high-dose and low-dose metronidazole-containing therapies (high-dose and low-dose therapies)...
2018: PloS One
https://www.readbyqxmd.com/read/29369454/comparative-study-of-helicobacter-pylori-eradication-rates-of-concomitant-therapy-vs-modified-quadruple-therapy-comprising-proton-pump-inhibitor-bismuth-amoxicillin-and-metronidazole-in-korea
#19
Jung Wan Choe, Sung Woo Jung, Seung Young Kim, Jong Jin Hyun, Young Kul Jung, Ja Seol Koo, Hyung Joon Yim, Sang Woo Lee
BACKGROUND: The standard triple Helicobacter pylori regimen now shows unacceptably low treatment success in Korea. Administration of the concomitant therapy for 10 days, which has a high cure rate, is recommended as an alternative first-line treatment in areas of high clarithromycin resistance including Korea. Recently, modified bismuth-containing quadruple therapy with amoxicillin (PAM-B therapy) showed excellent results, regardless of dual clarithromycin and metronidazole resistance...
January 25, 2018: Helicobacter
https://www.readbyqxmd.com/read/29369216/helicobacter-pylori-eradication-may-influence-timing-of-endoscopic-surveillance-for-gastric-cancer-in-patients-with-gastric-precancerous-lesions-a-retrospective-study
#20
Maria Pina Dore, Alice Cipolli, Matteo Walter Ruggiu, Alessandra Manca, Gabrio Bassotti, Giovanni Mario Pes
Chronic atrophic gastritis and intestinal metaplasia related to Helicobacter pylori infection, are major risk factors for gastric adenocarcinoma. Eradication of H pylori and endoscopy surveillance of precancerous lesions may reduce the risk and/or lead to early detection of gastric cancer improving survival. In this study, the progression of precancerous lesions after H pylori treatment was evaluated.Patients with incomplete or complete intestinal metaplasia and/or gastric atrophy at the index endoscopy, were examined for the extension/histological worsening of precancerous lesions at the endoscopy surveillance for gastric cancer...
January 2018: Medicine (Baltimore)
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