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https://www.readbyqxmd.com/read/29168600/molecular-characterization-of-helicobacter-pylori-resistance-to-rifamycins
#1
Constantin Hays, Christophe Burucoa, Philippe Lehours, Cong Tri Tran, Anaïs Leleu, Josette Raymond
INTRODUCTION: Antibiotic resistance is a major contributing factor in treatment failure of Helicobacter pylori eradication. Rifabutin (RB) is a rescue treatment and rifampicin (RP) is used to screen RB resistance in vitro. The aim of this study was to evaluate the rate of rifamycins resistance and to determine the mutations in the rpoB gene conferring resistance to discuss the current break point. METHODS: Antimicrobial susceptibility to RP was first determined by E-test for 1015 H...
November 23, 2017: Helicobacter
https://www.readbyqxmd.com/read/29161792/-trend-in-the-eradication-rates-of-helicobacter-pylori-infection-over-the-last-10-years-in-west-gyeonggi-do-korea-a-single-center-experience
#2
Jong Seol Park, Ji Eun Park, Byoung Soo Oh, Byung Wook Yoon, Hyun Ki Kim, Jae Won Lee, Nam Ho Kim, Won Seok Cho, Young Sik Woo, Jaehoon Jahng, Yong Sung Kim
Background/Aims: The eradication rate of Helicobacter pylori (H. pylori) has been decreasing recently in Korea due to antibiotics resistance. The aim of this study was to investigate the trend of eradication rate and clinical factors affecting the eradication rate of H. pylori in the last 10 years in west Gyeonggi-do, Korea. Methods: The trends of eradication rate of H. pylori, gender, age, concomitant mediations, and clinical factors were retrospectively evaluated in patients with H...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29158778/helicobacter-pylori-and-gut-microbiota-in-multiple-sclerosis-versus-alzheimer-s-disease-10-pitfalls-of-microbiome-studies
#3
Ah-Mee Park, Seiichi Omura, Mitsugu Fujita, Fumitaka Sato, Ikuo Tsunoda
Alteration of microbiota has been associated with intestinal, inflammatory, and neurological diseases. Abundance of "good bacteria" such as Bifidobacterium, or their products have been generally believed to be beneficial for any diseases, while "bad bacteria" such as pathogenic Helicobacter pylori are assumed to be always detrimental for hosts. However, this is not the case when we compare and contrast the association of the gut microbiota with two neurological diseases, multiple sclerosis (MS) and Alzheimer's disease (AD)...
August 2017: Clinical & Experimental Neuroimmunology
https://www.readbyqxmd.com/read/29149904/concomitant-sequential-and-7-day-triple-therapy-in-first-line-treatment-of-helicobacter-pylori-infection-in-korea-study-protocol-for-a-randomized-controlled-trial
#4
Hyuk Lee, Beom Jin Kim, Sang Gyun Kim, Jin Il Kim, Il Ju Choi, Yong Chan Lee, Jae G Kim, Jae J Kim
BACKGROUND: Most international guidelines recommend triple-therapy regimens consisting of a proton pump inhibitor, clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of Helicobacter pylori. However, the efficacy of 7-day clarithromycin-based standard triple therapy for H. pylori infection is currently unacceptable in Korea. In this study, we will compare the efficacy and safety of 7-day standard triple therapy, 10-day sequential therapy, and 10-day concomitant therapy for the first-line treatment of H...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/29138921/world-trends-for-h-pylori-eradication-therapy-and-gastric-cancer-prevention-strategy-by-h-pylori-test-and-treat
#5
REVIEW
Hidekazu Suzuki, Hideki Mori
Helicobacter pylori-associated gastritis leads to the development of gastric cancer. Kyoto global consensus report on H. pylori gastritis recommended H. pylori eradication therapy to prevent gastric cancer. To manage H. pylori infection, it is important to choose the appropriate regimen considering regional differences in resistance to clarithromycin and metronidazole. Quinolones and rifabutin-containing regimens are useful as third- and fourth-line rescue therapies.
November 14, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29135040/the-suppressive-effects-of-geniposide-and-genipin-on-helicobacter-pylori-infections-in-vitro-and-in-vivo
#6
Chiung-Hung Chang, Jin-Bin Wu, Jai-Sing Yang, Yen-Ju Lai, Chiu-Hsian Su, Chi-Cheng Lu, Yuan-Man Hsu
Geniposide and genipin have been found in Gardenia jasminoides Ellis, a traditional Chinese medicine that exhibits multiple biological functions. However, no report showing the effects of geniposide and genipin on gastric protection in Helicobacter pylori infections in vitro and in vivo has been done. In this study, we clarified how geniposide and genipin suppress H. pylori-mediated inflammation in gastric AGS cells and C57BL/6 mice. Our results demonstrated that genipin shows a strong ability to inhibit H...
November 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29133755/analysis-of-the-relationship-between-helicobacter-pylori-infection-and-diabetic-gastroparesis
#7
Ju Huang
BACKGROUND: Whether Helicobacter pylori infection is associated with diabetic gastroparesis (DGP) is unclear. This study aimed to investigate the potential correlation between H. pylori infection and DGP. METHODS: In this study, 163 patients with type 2 diabetes mellitus and 175 nondiabetic patients who were treated in our department were divided into DGP, simple diabetes, non-DGP (NDG), and normal groups based on their conditions. The H. pylori infection rate in each group was calculated...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29132551/vonoprazan-treatment-improves-gastrointestinal-symptoms-in-patients-with-gastroesophageal-reflux-disease
#8
Satoshi Shinozaki, Hiroyuki Osawa, Yoshikazu Hayashi, Hirotsugu Sakamoto, Yoshimasa Miura, Alan Kawarai Lefor, Hironori Yamamoto
The effects of vonoprazan, a new potassium-competitive acid blocker, on gastroesophageal reflux disease (GERD) symptom are not fully elucidated. The aim of this study is to determine the effect of vonoprazan on GERD and associated gastrointestinal symptoms. We retrospectively reviewed 88 Helicobacter pylori negative patients with GERD treated with vonoprazan 10 mg daily. Symptoms were evaluated using the Izumo scale, which reflects quality of life related to various abdominal symptoms. The rates of improvement and resolution of GERD symptoms were 86% (76/88) and 57% (50/88), respectively...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29131124/comparison-of-helicobacter-pylori-eradication-rates-of-2-week-levofloxacin-containing-triple-therapy-levofloxacin-containing-bismuth-quadruple-therapy-and-standard-bismuth-quadruple-therapy-as-a-first-line-regimen
#9
Evrim Kahramanoğlu Aksoy, Ferdane Pirinçci Sapmaz, Zeynep Göktaş, Metin Uzman, Yaşar Nazlıgül
OBJECTIVE: The aim of this study was to compare the efficacy and safety of 2-week levofloxacin containing triple therapy, levofloxacin containing bismuth quadruple therapy and standard bismuth containing quadruple therapy as a first-line regimen for eradication of Helicobacter pylori (H pylori). METHODS: A total of 329 patients with H pylori infection were randomly divided into three groups to receive: a) levofloxacin containing bismuth quadruple therapy, RBAL (rabeprazole 20 mg b...
November 3, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29119724/evaluation-of-first-line-bismuth-containing-7-day-concomitant-quintuple-therapy-for-helicobacter-pylori-eradication
#10
Jianfang Ye, Junbo Hong, Yin Zhu, Yong Xie, Xu Shu, Lingyu Luo, Chuan Xie, Zhenhua Zhu, Nonghua Lu
BACKGROUND: Helicobacter pylori infection is difficult to cure, mainly due to antibiotic resistance. We performed a trial to determine the efficacy and safety of a bismuth-containing 7-day concomitant quintuple regimen for the eradication of H. pylori. METHODS: Conducted from August 2015 to February 2016 at First Affiliated Hospital of Nanchang University, this prospective trial enrolled 70 untreated H. pylori-positive patients. Patients received 7-day quintuple therapy consisting of bismuth subcitrate 220 mg, esomeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, and metronidazole 400 mg, each twice daily...
November 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29110085/safety-of-first-line-triple-therapy-with-a-potassium-competitive-acid-blocker-for-helicobacter-pylori-eradication-in-children
#11
Chika Kusano, Takuji Gotoda, Sho Suzuki, Hisatomo Ikehara, Mitsuhiko Moriyama
BACKGROUND: Helicobacter pylori infection is a risk factor for gastric cancer, and it has been reported that eradication of H. pylori is effective for preventing such cancer. Recently, H. pylori eradication has been performed in children as first-line therapy against gastric cancer. Here, we report use of triple therapy with a potassium-competitive acid blocker (P-CAB) for H. pylori eradication in children. METHODS: H. pylori infection testing and eradication therapy began in fiscal year 2015 in junior high school students located in Yurihonjo city and Nikaho city, Akita prefecture, Japan...
November 7, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29102269/assessment-of-the-use-of-vitamin-c-and-e-supplements-concomitantly-to-antibiotic-treatment-against-helicobacter-pylori-a-systematic-review-and-meta-analysis
#12
Edgar Yaset Caicedo Ochoa, César Orlando Quintero Moreno, Yardany Rafael Méndez Fandiño, Sofía Catalina Sánchez Fonseca, Héctor Fabio Cortes Motta, Santiago Alejandro Guio Guerra
INTRODUCTION: Helicobacter pylori infections affect almost 50% of the world population, constituting a risk factor for benign and malignant gastrointestinal diseases. The increased resistance to antibiotic treatment against this infection represents a dilemma in the search of other therapeutic alternatives. OBJECTIVE: To determine the efficacy of the use of vitaminC and E supplements concomitantly to antibiotic treatment against H. pylori infections. METHODS: We performed a systematic review on the MedLine (PubMed), Embase and Cochrane Central Register of Clinical Trials (CENTRAL) databases, searching for studies evaluating the efficacy of vitaminC and/or E supplements in the antibiotic treatment of H...
November 1, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29094477/rescue-therapy-with-bismuth-quadruple-regimen-in-patients-with-helicobacter-pylori-resistant-strains
#13
Giulia Fiorini, Ilaria Maria Saracino, Angelo Zullo, Luigi Gatta, Matteo Pavoni, Dino Vaira
BACKGROUND: Bismuth quadruple therapy (BQT) is the recommended rescue therapy for Helicobacter pylori (H. pylori) infection. This study aimed to assess the efficacy and safety of a 10-day BQT regimen in patients who failed previous therapies and were infected with multiresistant H. pylori strains MATERIALS AND METHODS: Helicobacter pylori-infected patients underwent endoscopy, culture, and susceptibility test for clarithromycin, metronidazole, and levofloxacin. Treatment with three-in-one capsule (Pylera®) four times daily and esomeprazole 20 mg twice daily for 10 days was administered...
November 1, 2017: Helicobacter
https://www.readbyqxmd.com/read/29093589/-practical-issues-in-diagnostic-tests-for-helicobacter-pylori-infection-a-narrative-review
#14
Juan Sebastián Frías Ordoñez, William Otero Regino
H. pylori diagnosis is important because of the different clinical conditions associated with its presence, taking into account the different recommended indications for Helicobacter pylori erradication therapy and the broad spectrum of available diagnostic methods, it is necessary to achieve a timely diagnosis before and after eradication therapy. The success in the diagnosis is obtained from methods with high precision, those whose sensitivity and specificity is greater than 90%. This article aims to present advances in the various methods related to its detection, emphasizing their contributions and possible defects...
July 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29089267/quadruple-sequential-and-concomitant-first-line-therapies-for-h-pylori-eradication-a-prospective-randomized-study
#15
Vincenzo De Francesco, Stefano Pontone, Annamaria Bellesia, Gaetano Serviddio, Cristina Panetta, Rossella Palma, Angelo Zullo
BACKGROUND: Current Italian guidelines recommend 10-day bismuth-based or bismuth-free (sequential and concomitant) regimens for first-line H. pylori eradication. However, comparison among these regimens is lacking in our country. AIM: To perform a 'head-to-head' comparison among these three therapies as first-line treatment for H. pylori eradication in clinical practice. METHODS: This was a prospective, open-label randomized study enrolling consecutive patients diagnosed with H...
October 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29084052/personalizing-gastric-cancer-screening-with-predictive-modeling-of-disease-progression-biomarkers
#16
Rachel Walker, Jaime Mejia, Jae K Lee, Jose M Pimiento, Mokenge Malafa, Anna R Giuliano, Domenico Coppola, Heiko Enderling
Gastric cancer (GC) remains the third most common cause of cancer-related death worldwide. Infection with Helicobacter pylori is responsible for over 70% of GC incidence; colonization induces chronic inflammation, which can facilitate progression to intestinal metaplasia, dysplasia, and GC (Correa pathway). Although H. pylori eradication is a necessary first step in GC prevention, some patients continue to progress to advanced stage disease if substantial tissue damage has occurred or inflammation persists...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29082887/a-proposed-role-for-diffusible-signal-factors-in-the-biofilm-formation-and-morphological-transformation-of-helicobacter-pylori
#17
REVIEW
Pawel Krzyzek, Grazyna Gosciniak
Due to the increasing resistance of Helicobacter pylori to antibiotics, there is a growing need for new strategies for the effective eradication of this pathogen. The inhibition of quorum-sensing activity in most microorganisms leads to a decrease in virulence. A different reaction is observed in H. pylori, as interfering with the production of autoinducer-2 initiates biofilm formation and increases the survival of these bacteria. Therefore, it is believed that there is an alternative way to control the physiological changes of H...
October 30, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29076008/cumulative-helicobacter-pylori-eradication-rates-by-adopting-first-and-second-line-regimens-proposed-by-the-maastricht-iv-consensus-in-obese-patients-undergoing-gastric-bypass-surgery
#18
Rute M Cerqueira, M Correia, H Vilar, M C Manso
AIMS AND METHODS: Our aim was to assess, in obese patients undergoing Roux-en-Y gastric bypass (RYGB) surgery, the cumulative Helicobacter pylori (HP) eradication rates by adopting Maastricht IV guidelines in areas of high clarithromycin resistance rates (CLT)-14 days concomitant first-line therapy with proton-pump inhibitor (PPI) bid, CLT 500 mg bid, metronidazole (MTZ) 500 bid, and amoxicillin (AMX) 1000 mg bid and 14 days second-line therapy with PPI bid, AMX 1000 mg bid and levofloxacin (LVF) 500 mg od...
October 26, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29075827/helicobacter-pylori-treatment-antibiotics-or-probiotics
#19
REVIEW
Kamila Goderska, Sonia Agudo Pena, Teresa Alarcon
Treatment of Helicobacter pylori infection is important for the management of gastrointestinal disorders such as peptic ulcer and gastric cancer. Due to the increase in the prevalence of H. pylori resistance to antibiotics, triple therapy with clarithromycin is no longer the best treatment for H. pylori, especially in some areas where the local resistance to this antibiotic is higher than 20%. Alternative treatments have been proposed for the eradication of H. pylori. Some of them including novel antibiotics or classical ones in different combinations; these treatments are being used in the regular clinical practice as novel and more effective treatments...
October 26, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29072432/effectiveness-of-7-day-and-14-day-moxifloxacin-dexlansoprazole-based-triple-therapy-and-probiotic-supplement-for-helicobacter-pylori-eradication-in-thai-patients-with-non-ulcer-dyspepsia-a-double-blind-randomized-placebo-controlled-study
#20
Peranart Chotivitayatarakorn, Varocha Mahachai, Ratha-Korn Vilaichone
Background: Helicobacter pylori (H. pylori) is important cause of peptic ulcer and gastric cancer. Moxifloxacin is effective antibiotic for treatment for H. pylori. However, there were limited studies as first line therapy. Probiotics had been shown to decrease therapy-related side-effect and increase eradication rate. Aim of this study was to evaluate the efficacy of moxifloxacin-dexlansoprazole based triple therapy with probiotic for H. pylori treatment in Thailand. Methods: Patients with H. pylori infected gastritis were randomized to receive 7- or 14-day moxifloxacin-dexlansoprazole based triple therapy with probiotic or placebo...
October 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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