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eradication of h. pylori

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https://www.readbyqxmd.com/read/29672300/clinical-significance-of-reddish-depressed-lesions-observed-in-the-gastric-mucosa-after-helicobacter-pylori-eradication
#1
Takahiro Kotachi, Masanori Ito, Tomoyuki Boda, Mariko Kiso, Kazuhiko Masuda, Kosaku Hata, Toru Kawamura, Yoji Sanomura, Masaharu Yoshihara, Shinji Tanaka, Kazuaki Chayama
BACKGROUND AND AIM: Reddish depressed lesions (RDLs) frequently observed in patients following Helicobacter pylori eradication are indistinguishable from gastric cancer. We examined the clinical and histological feature of RDLs and its relevant endoscopic diagnosis including magnifying narrow-band imaging (M-NBI). METHODS: We enrolled 301 consecutive patients with H. pylori eradication who underwent endoscopy using white light imaging (WLI). We examined the prevalence and host factors contributing to the presence of RDLs...
April 19, 2018: Digestion
https://www.readbyqxmd.com/read/29671784/epidemiology-of-helicobacter-pylori-and-caga-positive-infections-and-global-variations-in-gastric-cancer
#2
REVIEW
Jin Young Park, David Forman, Langgeng Agung Waskito, Yoshio Yamaoka, Jean E Crabtree
Gastric cancer is a major health burden and is the fifth most common malignancy and the third most common cause of death from cancer worldwide. Development of gastric cancer involves several aspects, including host genetics, environmental factors, and Helicobacter pylori infection. There is increasing evidence from epidemiological studies of the association of H. pylori infection and specific virulence factors with gastric cancer. Studies in animal models indicate H. pylori is a primary factor in the development of gastric cancer...
April 19, 2018: Toxins
https://www.readbyqxmd.com/read/29671413/non-variceal-upper-gastrointestinal-bleeding
#3
REVIEW
Angel Lanas, Jean-Marc Dumonceau, Richard H Hunt, Mitsuhiro Fujishiro, James M Scheiman, Ian M Gralnek, Helen E Campbell, Alaa Rostom, Càndid Villanueva, Joseph J Y Sung
Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori infection or use of NSAIDs and low-dose aspirin (LDA), are the most common cause. Although the incidence and mortality associated with NVUGIB have been decreasing owing to considerable advances in the prevention and management of NVUGIB over the past 20 years, it remains a common clinical problem with an annual incidence of ∼67 per 100,000 individuals in the United States in 2012...
April 19, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29670656/the-antibacterial-activity-of-mass-galla-chinesis-et-camelliae-fermentata-on-helicobacter-pylori-infection
#4
Jing Yu, Hui Ye, Jiang Li, Ning Li, Zong-Ming Shi, Xue-Zhi Zhang
Mass Galla chinesis et camelliae Fermentata ( Chinese gall leaven , CGL) was investigated for activities against Helicobacter pylori (H. pylori) both in vitro and in vivo . The agar dilution method and time-kill curves, as in vitro assays and an in vivo study using a Kunming mice model, were performed. CGL demonstrated a strong anti- Helicobacter pylori activity in vitro with the minimal inhibitory concentrations (MICs) against multiple H. pylori strains of 0.5~8 mg/ml and the decreasing trend time-kill curves when increasing CGL concentrations...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29669354/effectiveness-and-safety-of-pylera%C3%A2-in-patients-infected-by-helicobacter-pylori-a-multicenter-retrospective-real-life-study
#5
Antonio Tursi, Marilisa Franceschi, Leonardo Allegretta, Edoardo Savarino, Rudi De Bastiani, Walter Elisei, Gianluca Baldassarre, Antonio Ferronato, Serena Scida, Chiara Miraglia, Antonio Penna, Claudio Licci, Giovanni Luca Rizzo, Giuseppe Pranzo, Claudio Cassieri, Giovanni Brandimarte, Marcello Picchio, Francesco Di Mario
BACKGROUND: Our aims were to assess the real life effectiveness and safety of the new bismuth-containing quadruple therapy in a large population of patients infected by Helicobacter pylori. METHODS: Consecutive dyspeptic H. pylori-positive patients were enrolled, both naïve for treatment and already unsuccessfully treated. Patients were treated with Pylera® 3 capsules 4 times/daily plus omeprazole 20 mg or esomeprazole 40 mg 2 times/daily for 10 days. Eradication was confirmed using a urea-breath test (at least 30 days after the end of the treatment)...
April 17, 2018: Digestive Diseases
https://www.readbyqxmd.com/read/29666614/-helicobacter-pylori-the-latent-human-pathogen-or-an-ancestral-commensal-organism
#6
REVIEW
Jackie Li, Guillermo I Perez-Perez
We dedicated this review to discuss Helicobacter pylori as one of the latest identified bacterial pathogens in humans and whether its role is mainly as a pathogen or a commensal. Diseases associated with this bacterium were highly prevalent during the 19th century and gradually have declined. Most diseases associated with H. pylori occurred in individuals older than 40 years of age. However, acquisition of H. pylori occurs mainly in young children inside the family setting. Prevalence and incidence of H. pylori has had a dramatic change in the last part of the 20th century and beginning of the 21th century...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29663251/histopathological-findings-in-morbid-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-does-h-pylori-infection-effective-on-pathological-changes
#7
Ramazan İlyas Öner, Sabri Özdaş
AıM: To determine the prevalence of histopathological findings requiring clinical follow-up in morbidly obese patients undergoing laparoscopic sleeve gastrectomy (LSG) and evaluate the relationship between these findings and Helicobacter pylori as well as to add more data to the published literature in this regard. MATERıAL AND METHODS: Overall, 161 morbidly obese patients with body mass index (BMI) > 40 kg/m2 who underwent LSG between May 1, 2014 and May 31, 2017 were retrospectively included in the study...
April 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29662291/punctual-mutations-in-23s-rrna-gene-of-clarithromycin-resistant-helicobacter-pylori-in-colombian-populations
#8
Andrés Jenuer Matta, Diana Carolina Zambrano, Alvaro Jairo Pazos
AIM: To characterize punctual mutations in 23S rRNA gene of clarithromycin-resistant Helicobacter pylori ( H. pylori ) and determine their association with therapeutic failure. METHODS: PCR products of 23S rRNA gene V domain of 74 H. pylori isolates; 34 resistant to clarithromycin (29 from a low-risk gastric cancer (GC) population: Tumaco-Colombia, and 5 from a high-risk population: Tuquerres-Colombia) and 40 from a susceptible population (28 from Tumaco and 12 from Túquerres) were sequenced using capillary electrophoresis...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29660462/anti-helicobacterpylori-effectiveness-and-targeted-delivery-performance-of-amoxicillin-uccs-2-tpp-nanoparticles-based-on-ureido-modified-chitosan-derivative
#9
Zi-Wei Jing, Min Luo, Yi-Yang Jia, Chen Li, Si-Yuan Zhou, Qi-Bing Mei, Bang-Le Zhang
The amoxicillin-UCCs-2/TPP nanoparticles constructed with ureido-modified chitosan derivative UCCs-2 and sodium tripolyphosphate (TPP) played an important role to deliver drug to achieve more efficacious and specific eradication of Helicobacterpylori (H. pylori) in vitro. In this study, the anti-H. pylori effectiveness in vivo and uptake mechanism was investigated in details, including the effect of temperature, pH values and the addition of competitive substrate urea on uptake. Compared with unmodified nanoparticles, a more efficacious and specific anti-H...
April 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29657940/levofloxacin-containing-versus-clarithromycin-containing-therapy-for-helicobacter-pylori-eradication-a-prospective-randomized-controlled-clinical-trial
#10
Vahid Sebghatollahi, Maryam Soheilipour, Mahsa Khodadoostan, Alireza Shavakhi, Ahmad Shavakhi
Background: This study evaluated the clinical efficacy and tolerability of a 14-day course of bismuth-based quadruple therapy including tinidazole and levofloxacin in compare to a 14-day bismuth-based quadruple therapy including clarithromycin as first-line treatment for Helicobacter pylori infection in Iranian adults. Materials and Methods: The study was a prospective, parallel group, randomized controlled, clinical trial that conducted on 150 patients with H. pylori infection...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29657020/helicobacter-pylori-infection-aggravates-diet-induced-nonalcoholic-fatty-liver-in-mice
#11
Cong He, Dandan Cheng, Huan Wang, Ketao Wu, Yin Zhu, Nonghua Lu
BACKGROUND: Previous epidemiological studies have suggested a link between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD), yet animal studies are lacking to elucidate this association. In this study, we evaluated the potential effects of H. pylori infection on NAFLD in mice. METHODS: We first established two strains of H. pylori infected mice model with either chow diet or high fat diet (HFD). The body and liver weight, blood glucose, serum transaminases and lipid levels and markers of hepatic inflammation were measured...
April 12, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29652033/the-effect-of-virulence-genotypes-of-helicobacter-pylori-on-eradication-therapy-in-children
#12
Shuang-Hong Zhang, Xuan Zhu, Bi-Min Li, Hong Li
Background/Aim: It is important to eradicate Helicobacter pylori at an early stage in patients during childhood to potentially prevent the development of H. pylori-related diseases. Studies have demonstrated that the virulence genotype of H. pylori influences the efficacy of eradication therapy. The efficacy of triple therapy has decreased significantly, which has seriously affected the clinical outcome of children with H. pylori infection. In this study we aimed to investigate the influence of virulence genotypes of H...
April 13, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29609070/equivalent-efficacies-of-reverse-hybrid-and-bismuth-quadruple-therapies-in-eradication-of-helicobacter-pylori-infection-in-a-randomized-controlled-trial
#13
Ping-I Hsu, Feng-Woei Tsay, David Y Graham, Tzung-Jiun Tsai, Kuo-Wang Tsai, John Y Kao, Nan-Jing Peng, Chao-Hung Kuo, Sung-Shuo Kao, Huay-Min Wang, Te-Fu Lin, Deng-Chyang Wu
BACKGROUND & AIMS: Bismuth quadruple therapy is recommended as a first-line treatment for Helicobacter pylori infection in the United States but hybrid therapy is an alternative option. Reverse hybrid therapy (proton pump inhibitor plus amoxicillin for 14 days, and clarithromycin plus metronidazole for the initial 7 days) is a simplified hybrid treatment. We aimed to assess the efficacies of reverse hybrid therapy vs bismuth quadruple therapy as first-line treatments for patients with H pylori infection in a randomized trial...
March 30, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29605555/randomized-controlled-trial-ppi-based-triple-therapy-containing-metronidazole-versus-clarithromycin-as-first-line-treatment-for-helicobacter-pylori-in-adolescents-and-young-adults-in-japan
#14
Katushiro Mabe, Masumi Okuda, Shogo Kikuchi, Kenji Amagai, Rie Yoshimura, Mototsugu Kato, Naoya Sakamoto, Masahiro Asaka
BACKGROUND/AIMS: Treating Helicobacter pylori infection in young people is effective for preventing gastric cancer. This study compares the efficacy of triple therapies in adolescents and young adults in Japan. METHODS: This multicenter, randomized trial was conducted between February 2012 and March 2015. Infected participants were stratified into adolescents (13-19 years) and young adults (20-39 years). They were randomly assigned to a clarithromycin based (PAC) or metronidazole based (PAM) triple therapy for 1 week...
March 28, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29602600/usefulness-of-rapid-urease-test-samples-for-molecular-analysis-of-clarithromycin-resistance-in-helicobacter-pylori
#15
María R Baroni, Pamela Bucci, Rita N Giani, Antonela Giusti, Fabian A Tedeschi, Emiliano Salvatierra, Yanina Barbaglia, Félix Jimenez, Fabian E Zalazar
Helicobacter pylori is a gastric pathogen that is widely recognized as a causative agent of gastric disease. Its eradication is variable, mainly due to increased resistance to clarithromycin. Our objective was: to evaluate (i) if the biopsy specimen used for the rapid urease test is a useful sample to detect resistance to clarithromycin by PCR-RFLP and (ii) the distribution of A2142G and A2143G point mutations in the 23S rRNA gene, in relation to virulence factors in our region. Gastric specimens were collected from adult dyspeptic patients (n=141) and H...
March 27, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29600697/pharmacological-considerations-and-step-by-step-proposal-for-the-treatment-of-helicobacter-pylori-infection-in-the-year-2018
#16
Rinaldo Pellicano, Rocco M Zagari, Songhua Zhang, Giorgio M Saracco, Steven F Moss
Over the past 30 years, multidrug regimens consisting of a proton pump inhibitor (PPI) and two or three antibiotics have been used in treating Helicobacter pylori (H. pylori) infection. In clinical practice, the optimal regimen to cure H. pylori infection should be decided regionally. Considering the first treatment, the Maastricht V/Florence Consensus Report and the American College of Gastroenterology Clinical Management Guideline highlight that in countries with low clarithromycin resistance rates (<15%), an empiric clarithromycin-based regimen can be used...
March 30, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29596646/new-single-capsule-of-bismuth-metronidazole-and-tetracycline-given-with-omeprazole-versus-quadruple-therapy-consisting-of-bismuth-omeprazole-amoxicillin-and-clarithromycin-for-eradication-of-helicobacter-pylori-in-duodenal-ulcer-patients-a-chinese-prospective
#17
Yong Xie, Xiaolin Pan, Yan Li, Huahong Wang, Yiqi Du, Jianming Xu, Jiangbin Wang, Zhirong Zeng, Ye Chen, Guoxin Zhang, Kaichun Wu, Dongsheng Liu, Nonghua Lv
Objectives: To assess the efficacy and safety of omeprazole given with the new single capsule of bismuth, metronidazole and tetracycline (OBMT) compared with quadruple treatment consisting of omeprazole, bismuth, amoxicillin and clarithromycin (OBAC) for Helicobacter pylori eradication in duodenal ulcer patients. Methods: This single-blind, randomized multicentre trial was conducted in 10 tertiary hospitals in China between January 2013 and April 2014. Patients were randomized to receive 10 days of OBMT therapy or 10 days of OBAC therapy...
March 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29593799/comparison-of-the-efficacy-and-safety-of-hybrid-and-sequential-therapies-as-a-first-line-regimen-for-helicobacter-pylori-infection-in-turkey
#18
Ayşe Kefeli, Sebahat Başyigit, Abdullah Ozgur Yeniova, Serdar Ozkan, Yasar Nazligul
Introduction: Helicobacter pylori infection is a common infection worldwide. The most frequently recommended treatment for eradication of H. pylori remains triple therapy. In this study, we compared sequential and hybrid regimens for H. pylori eradication in a region of Turkey with high resistance to clarithromycin. Material and methods: Three hundred and forty H. pylori -positive patients were enrolled in the study. The subjects were randomly divided into two groups...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29587295/helicobacter-pylori-eradication-therapy-ameliorates-latent-digestive-symptoms-in-chronic-atrophic-gastritis
#19
Shinya Yamada, Naoya Tomatsuri, Takumi Kawakami, Yoshikazu Nakatsugawa, Takeshi Nishimura, Hideki Fujii, Hideki Sato, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida
BACKGROUND/AIMS: This study investigated the effect of Helicobacter pylori eradication therapy on latent digestive symptoms in chronic atrophic gastritis. METHODS: We enrolled 650 health checkup patients who underwent eradication therapy for chronic gastritis and completed a self-report questionnaire before and after the treatment between January 2014 and December 2016 at the Japanese Red Cross Society Kyoto Daiichi Hospital. RESULTS: H. pylori eradication therapy for chronic atrophic gastritis improved latent digestive symptoms, including both the acid reflux and dyspepsia components in the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) scores...
March 27, 2018: Digestion
https://www.readbyqxmd.com/read/29580123/ethnic-and-racial-difference-in-helicobacter-pylori-infection-in-patients-with-immune-thrombocytopenia-treated-at-a-major-urban-medical-center
#20
Caitlin M O'Neill, Ilene C Weitz, Casey O'Connell, Howard A Liebman
Immune thrombocytopenia (ITP) is an autoimmune disorder with a complex immunopathology and pathogenesis characterized by thrombocytopenia and bleeding manifestations. The disorder is separated into primary (idiopathic) ITP and secondary ITP, when associated with other immune or lymphoproliferative disorders and certain chronic infections. Helicobacter pylori (H. pylori) is a recognized bacterial cause of ITP. In regions with high prevalence of infection, bacterial eradication has resulted in improvement in platelet count...
March 26, 2018: Platelets
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