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https://www.readbyqxmd.com/read/29755819/vitreoretinal-interface-characteristics-in-eyes-with-idiopathic-macular-holes-qualitative-and-quantitative-analysis
#1
Arzu Seyhan Karatepe, Jale Menteş, E Tansu Erakgün, Filiz Afrashi, Serhad Nalçacı, Cezmi Akkın, Yeşim Ateş
Objectives: To determine the qualitative and quantitative vitreoretinal interface characteristics with spectral domain optical coherence tomography (SD-OCT) in eyes with macular hole (MH) and investigate their relation with best corrected visual acuity (BCVA) and MH duration. Materials and Methods: Sixty-one eyes of 46 consecutive patients diagnosed with idiopathic MH were included in the study. The mean age of the patients was 66.7±7.5 (51-79) years. Complete ophthalmologic examination and SD-OCT examination were performed in all eyes and MH stages were determined according to SD-OCT findings...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29748879/poly-l-ornithine-fucoidan-coated-calcium-carbonate-microparticles-by-layer-by-layer-self-assembly-technique-for-cancer-theranostics
#2
Pei Wang, Ranjith Kumar Kankala, Jingqian Fan, Ruimin Long, Yuangang Liu, Shibin Wang
Recently, the layer-by-layer (LbL) self-assembly technology has attracted the enormous interest of researchers in synthesizing various pharmaceutical dosage forms. Herewith, we designed a biocompatible drug delivery system containing the calcium carbonate microparticles (CaCO3 MPs) that coated with the alternatively charged polyelectrolytes, i.e., poly-L-ornithine (PLO)/fucoidan by LbL self-assembly process (LbL MPs). Upon coating with the polyelectrolytes, the mean particle size of MPs obtained from SEM observations increased from 1...
May 10, 2018: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29744441/inhibition-of-hela-cell-growth-by-doxorubicin-loaded-and-tuftsin-conjugated-arginate-peg-microparticles
#3
Tianmu Hu, Anwar Saeed Ahmed Qahtan, Lei Lei, Zhixin Lei, Dapeng Zhao, Hemin Nie
In order to improve the release pattern of chemotherapy drug and reduce the possibility of drug resistance, poly(ethylene glycol amine) (PEG)-modified alginate microparticles (ALG-PEG MPs) were developed then two different mechanisms were employed to load doxorubicin (Dox): 1) forming Dox/ALG-PEG complex by electrostatic attractions between unsaturated functional groups in Dox and ALG-PEG; 2) forming Dox-ALG-PEG complex through EDC-reaction between the amino and carboxyl groups in Dox and ALG, respectively...
March 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29743921/use-and-conservation-of-medicinal-plants-by-indigenous-people-of-gozamin-wereda-east-gojjam-zone-of-amhara-region-ethiopia-an-ethnobotanical-approach
#4
Nigussie Amsalu, Yilkal Bezie, Mulugeta Fentahun, Addisu Alemayehu, Gashaw Amsalu
An ethnobotanical study of medicinal plants (MPs) used by the local community has been carried out from January 5, 2014, to February 15, 2015, in Gozamin Wereda of East Gojjam Zone, Ethiopia. The purpose of this study was to identify and document the use and conservation of MPs, along with indigenous knowledge of Gozamin community. Data were collected using semistructured interview, field observation, and focus group discussions. The collected data were assessed quantitatively using fidelity level, Jaccard's Coefficient of Similarity, paired comparisons, direct matrix, and preference rankings...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29735373/natural-history-of-echocardiographic-abnormalities-in-mucopolysaccharidosis-iii
#5
Carolyn M Wilhelm, Kristen V Truxal, Kim L McBride, John P Kovalchin, Kevin M Flanigan
BACKGROUND: Mucopolysaccharidosis (MPS) type III, Sanfilippo Syndrome, is an autosomal recessive lysosomal storage disorder. MPS I and II patients often develop cardiac involvement leading to early mortality, however there are limited data in MPS III. The objective of this study is to describe cardiac abnormalities in a large group of MPS III patients followed in a longitudinal natural history study designed to determine outcome measures for gene transfer trials. METHODS: A single center study of MPS III patients who were enrolled in the Nationwide Children's Hospital natural history study in 2014...
April 27, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29728280/intensification-of-uv-c-tertiary-treatment-disinfection-and-removal-of-micropollutants-by-sulfate-radical-based-advanced-oxidation-processes
#6
J Rodríguez-Chueca, C García-Cañibano, R-J Lepistö, Á Encinas, J Pellinen, J Marugán
This study explores the enhancement of UV-C tertiary treatment by sulfate radical based Advanced Oxidation Processes (SR-AOPs), including photolytic activation of peroxymonosulfate (PMS) and persulfate (PS) and their photocatalytic activation using Fe(II). Their efficiency was assessed both for the inactivation of microorganisms and the removal or micropollutants (MPs) in real wastewater treatment plant effluents. Under the studied experimental range (UV-C dose 5.7-57 J/L; UV-C contact time 3 to 28 s), the photolysis of PMS and PS (0...
April 21, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29705420/short-communication-in-vitro-rumen-gas-production-and-starch-degradation-of-starch-based-feeds-depend-on-mean-particle-size
#7
A Gallo, G Giuberti, A S Atzori, F Masoero
Our objective was to model the effect of mean particle size (mPS) on in vitro rumen starch degradation (IVSD) and the kinetics of gas production for different starch-based feeds. For each feed, 2 batches of the same grains were separately processed through 2 different mills (cutter or rotor speed mills), with or without different screens to achieve a wide range of mPS (0.32 to 3.31 mm for corn meals; 0.19 to 2.81 mm for barley meals; 0.16 to 2.13 mm for wheat meals; 0.28 to 2.32 mm for oat meals; 0.21 to 2...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29700418/smarca4-deficient-undifferentiated-uterine-sarcoma-malignant-rhabdoid-tumor-of-the-uterus-a-clinicopathologic-entity-distinct-from-undifferentiated-carcinoma
#8
David L Kolin, Fei Dong, Michele Baltay, Neal Lindeman, Laura MacConaill, Marisa R Nucci, Christopher P Crum, Brooke E Howitt
Small cell carcinoma of the ovary, hypercalcemic type is a rare, aggressive malignancy which usually occurs in young women and is characterized by mutations in SMARCA4, with few other alterations. We recently encountered uterine tumors with morphologic, immunohistochemical, and genetic similarities to small cell carcinoma of the ovary, hypercalcemic type. Herein we report the clinicopathologic and molecular features (using a targeted massively parallel sequencing [MPS] assay) of these tumors. The cases were diagnosed on cervical and endometrial biopsies (n = 2, 34, and 29 years) or hysterectomy and bilateral salpingo-oophorectomy (n = 3, 25, 33, and 58 years)...
April 26, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29684694/microplastics-in-different-tissues-of-fish-and-prawn-from-the-musa-estuary-persian-gulf
#9
Sajjad Abbasi, Naghmeh Soltani, Behnam Keshavarzi, Farid Moore, Andrew Turner, Mina Hassanaghaei
Commercially-important species of fish and a crustacean from four sites in the Musa estuary and a site in the Persian Gulf have been analysed for the presence and location of microplastics (MPs). A total of 828 MPs were detected in the guts (gastrointestinal tracts), skin, muscle, gills and liver of demersal and pelagic fish (Platycephalus indicus, Saurida tumbil, Sillago sihama, Cynoglossus abbreviatus) from all five sites and in the exoskeleton and muscle of the tiger prawn, Penaeus semisulcatus, from three sites...
April 18, 2018: Chemosphere
https://www.readbyqxmd.com/read/29683519/children-with-mucopolysaccharidosis-risk-progressive-visual-dysfunction-despite-haematopoietic-stem-cell-transplants
#10
Kristina Teär Fahnehjelm, Monica Olsson, Enping Chen, Jürg Hengstler, Karin Naess, Jacek Winiarski
AIM: This prospective study assessed the long-term ocular and visual outcomes of children with mucopolysaccharidoses type I Hurler syndrome (MPS IH) who were treated with haematopoietic stem cell transplants (HSCT). METHODS: Clinical ophthalmological assessments were performed on eight patients at the St Erik Eye Hospital, Stockholm, Sweden, from 2001-2018: The median age at diagnosis and HSCT were 12.2 (range 5.0-16.4) and 16.7 (8.0-20.4) months. The last eye examination was at a median of 13...
April 23, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29679222/warranty-period-of-normal-stress-myocardial-perfusion-imaging-in-hypertensive-patients-a-parametric-survival-analysis
#11
Wanda Acampa, Francesco Rozza, Emilia Zampella, Roberta Assante, Teresa Mannarino, Carmela Nappi, Ciro Mainolfi, Mario Petretta, Bruno Trimarco, Alberto Cuocolo
BACKGROUND: We evaluated the warranty period of a normal stress myocardial perfusion single-photon emission computed tomography (MPS) in hypertensive patients. METHODS AND RESULTS: A total of 471 consecutive hypertensive patients with suspected coronary artery disease and normal perfusion at stress MPS were followed for a mean of 76 ± 21 months. Endpoint events were cardiac death or nonfatal myocardial infarction. With Cox analysis, age (hazard ratio 1.1, P < ...
April 20, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29674212/how-microplastics-quantities-increase-with-flood-events-an-example-from-mersin-bay-ne-levantine-coast-of-turkey
#12
Sedat Gündoğdu, Cem Çevik, Berna Ayat, Burak Aydoğan, Serkan Karaca
Floods caused by heavy rain carry significant amounts of pollutants into marine environments. This study evaluates the effect of multiple floods that occurred in the northeastern Mediterranean region in Turkey between December 2016 and January 2017 on the microplastic pollution in the Mersin Bay. Sampling was repeated in four different stations both before and after the flood period, and it was determined that in the four stations, there was an average of 539,189 MPs/km2 before the flood, and 7,699,716 MPs/km2 afterwards, representing a 14-fold increase...
April 16, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29673442/subchronic-oral-toxicity-of-silica-nanoparticles-and-silica-microparticles-in-rats
#13
Chun Lai Liang, Qian Xiang, Wen Ming Cui, Jin Fang, Na Na Sun, Xiao Peng Zhang, Yong Ning Li, Hui Yang, Zhou Yu, Xu Dong Jia
OBJECTIVE: To investigate the subchronic oral toxicity of silica nanoparticles (NPs) and silica microparticles (MPs) in rats and to compare the difference in toxicity between two particle sizes. METHODS: Sprague-Dawley rats were randomly divided into seven groups: the control group; the silica NPs low-, middle-, and high-dose groups; and the silica MPs low-, middle-, and high-dose groups [166.7, 500, and 1,500 mg/(kg•bw•day)]. All rats were gavaged daily for 90 days, and deionized water was administered to the control group...
March 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29649608/standalone-cranio-cervical-decompression-is-feasible-in-children-with-mucopolysaccharidosis-type-i-iva-and-vi
#14
Harald Krenzlin, Ta-Chih Tan, Christina Lampe, Christian Lampe, Markus Knuf, Peter Horn, Manfred Schwarz
BACKGROUND CONTEXT: In patients with Mucopolysaccharidosis (MPS), glycosaminoglycans deposits in the dura mater and supporting ligaments cause spinal cord compression and consecutive myelopathy, predominantly of the cranio-cervical junction. Disease characteristics of cranio-cervical stenosis (CCS) in MPS patients differ profoundly from other hereditary and degenerative forms. Due to high peri-procedural morbidity and mortality, MPS patients pose a substantial challenge to the unexperienced medical care provider...
April 9, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29615107/development-and-validation-of-a-tool-to-assess-knowledge-of-healthy-lifestyles-in-early-grade-school-children
#15
Salim R Surani, Sean Hesselbacher, Zoya Surani, Moinuddin Mokhasi, Saherish S Surani, Jose Guardiola, Lauren Quisenberry, Sara S Surani
OBJECTIVE: Healthy habits during childhood has been of prime importance. We aimed to gather baseline information about health habits from children in kindergarten and first grade (typically ages 5-7). Our objectives were to validate the questionnaire in assessing health habits, as well as the electronic audience response system, iClicker (MPS, Gordonsville, VA), in this age group. RESULTS: The questionnaire completed by 75 kindergarteners and 66 first graders. For the first graders, questions involving healthy choices were answered correctly 78% of the time (range 8-94%) and had 84% agreement on repeat testing (range 64-93%)...
April 3, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29579000/use-of-a-midliner-positioning-system-for-prevention-of-dolichocephaly-in-preterm-infants
#16
Dana B McCarty, Shannon OʼDonnell, Ricki F Goldstein, P Brian Smith, Kimberley Fisher, William F Malcolm
PURPOSE: The purpose of this study was to determine effectiveness of a midliner positioning system (MPS, Tortle Midliner) for preventing dolichocephaly. METHODS: This was a nonrandomized, prospective study of 30 premature infants (study cohort, SC) using an MPS compared with a retrospective study cohort (RSC) of 65 infants who received standard of care intervention. RESULTS: RSC baseline cranial index (CI) of 80% and final CI of 77% significantly decreased over an average 5...
April 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/29564448/intra-articular-tsg-6-delivery-from-heparin-based-microparticles-reduces-cartilage-damage-in-a-rat-model-of-osteoarthritis
#17
Liane E Tellier, Elda A Treviño, Alexandra L Brimeyer, David S Reece, Nick J Willett, Robert E Guldberg, Johnna S Temenoff
As a potential treatment for osteoarthritis (OA), we have developed injectable and hydrolytically degradable heparin-based biomaterials with tunable sulfation for the intra-articular delivery of tumor necrosis factor-alpha stimulated gene-6 (TSG-6), a protein known to inhibit plasmin which may degrade extracellular matrix within OA joints. We first assessed the effect of heparin sulfation on TSG-6 anti-plasmin activity and found that while fully sulfated (Hep) and heparin desulfated at only the N position (Hep-N) significantly enhanced TSG-6 bioactivity in vitro, fully desulfated heparin (Hep-) had no effect, indicating that heparin sulfation plays a significant role in modulating TSG-6 bioactivity...
March 22, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29552914/identification-of-novel-hemostatic-biomarkers-of-adverse-clinical-events-in-patients-implanted-with-a-continuous-flow-left-ventricular-assist-device
#18
Nathan McClane, Walter Jeske, Jeanine M Walenga, Vicki Escalante, Debra Hoppensteadt, Jeffrey Schwartz, Mamdouh Bakhos
Heart failure affects over 5 million people in the United States. Its rising prevalence and the limited supply of donor hearts is increasing the use of mechanical cardiac support with the implantation of continuous-flow ventricular assist devices (CF-VAD). Patients with CF-VAD implants are at risk of complications, specifically adverse hemostatic events such as nonsurgical bleeding and thrombosis. Development of a pump thrombus requires clinical intervention and/or surgical replacement significantly increasing the risk of patient morbidity and mortality...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29543433/toxicological-profiling-of-metal-oxide-nanoparticles-in-liver-context-reveals-pyroptosis-in-kupffer-cells-and-macrophages-versus-apoptosis-in-hepatocytes
#19
Vahid Mirshafiee, Bingbing Sun, Chong Hyun Chang, Yu-Pei Liao, Wen Jiang, Jinhong Jiang, Xiangsheng Liu, Xiang Wang, Tian Xia, Andre E Nel
The liver and the mononuclear phagocyte system (MPS) is a frequent target for engineered nanomaterials (ENMs), either as a result of particle uptake and spread from primary exposure sites or systemic administration of therapeutic and imaging nanoparticles. In this study, we performed a comparative analysis of the toxicological impact of 29 metal oxide (MOx) nanoparticles (NPs), some commonly used in consumer products, in transformed or primary Kupffer cells (KCs) and hepatocytes. Not only did we observe differences between KC and hepatocytes, but also differences in the toxicological profiles of transition metal oxides (TMOs, e...
March 15, 2018: ACS Nano
https://www.readbyqxmd.com/read/29540740/interconnected-microphysiological-systems-for-quantitative-biology-and-pharmacology-studies
#20
Collin D Edington, Wen Li Kelly Chen, Emily Geishecker, Timothy Kassis, Luis R Soenksen, Brij M Bhushan, Duncan Freake, Jared Kirschner, Christian Maass, Nikolaos Tsamandouras, Jorge Valdez, Christi D Cook, Tom Parent, Stephen Snyder, Jiajie Yu, Emily Suter, Michael Shockley, Jason Velazquez, Jeremy J Velazquez, Linda Stockdale, Julia P Papps, Iris Lee, Nicholas Vann, Mario Gamboa, Matthew E LaBarge, Zhe Zhong, Xin Wang, Laurie A Boyer, Douglas A Lauffenburger, Rebecca L Carrier, Catherine Communal, Steven R Tannenbaum, Cynthia L Stokes, David J Hughes, Gaurav Rohatgi, David L Trumper, Murat Cirit, Linda G Griffith
Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion. Here, we report an approach to co-culture multiple different MPSs linked together physiologically on re-useable, open-system microfluidic platforms that are compatible with the quantitative study of a range of compounds, including lipophilic drugs. We describe three different platform designs - "4-way", "7-way", and "10-way" - each accommodating a mixing chamber and up to 4, 7, or 10 MPSs...
March 14, 2018: Scientific Reports
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