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https://www.readbyqxmd.com/read/28207887/platelet-monocyte-derived-and-tissue-factor-carrying-circulating-microparticles-are-related-to-acute-myocardial-infarction-severity
#1
Gemma Chiva-Blanch, Kristian Laake, Peder Myhre, Vibeke Bratseth, Harald Arnesen, Svein Solheim, Lina Badimon, Ingebjørg Seljeflot
OBJECTIVE: Circulating microparticles (cMPs) are phospholipid-rich vesicles released from cells when activated or injured, and contribute to the formation of intracoronary thrombi. Tissue factor (TF, CD142) is the main trigger of fibrin formation and TF-carrying cMPs are considered one of the most procoagulant cMPs. Similar types of atherosclerotic lesions may lead to different types of AMI, although the mechanisms behind are unresolved. Therefore, we aimed to investigate the phenotype of cMPs found in plasma of ACS patients and its relation to AMI severity and thrombotic burden...
2017: PloS One
https://www.readbyqxmd.com/read/28196921/noninvasive-prenatal-screening-of-fetal-aneuploidy-without-massively-parallel-sequencing
#2
Chenming Xu, Ting Wang, Chao Liu, Hong Li, Xiaoyan Chen, Huanhuan Zhu, Songchang Chen, Qiuhong Xin, Jing Tao, Liming Huang, Zhengwen Jiang
BACKGROUND: Noninvasive prenatal screening (NIPS) using plasma cell-free DNA has gained tremendous popularity in the clinical assessment of fetal aneuploidy. Most, if not all, of these tests rely on complex and expensive massively parallel sequencing (MPS) techniques, hindering the use of NIPS as a common screening procedure. METHODS: We have developed and optimized an MPS-independent noninvasive genetic test that can rapidly detect fetal aneuploidy at considerably lower costs...
February 14, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28193505/statistical-modelling-of-ion-pgm-hid-str-10-plex-mps-data
#3
Søren B Vilsen, Torben Tvedebrink, Helle Smidt Mogensen, Niels Morling
We investigated the results of short tandem repeat (STR) markers of dilution series experiments and reference profiles generated using the Ion PGM massively parallel sequencing platform utilising the HID STR 10-plex panel. The STR markers were identified by the marker specific flanking regions of the STR region. We investigated the following: (1) the usage of quality measures for identifying substitution errors, (2) the heterozygote balance and compared it to that of capillary electrophoresis (CE), (3) the stability of the coverage and the consequence of IonExpress Barcode adapter (IBA) sampling with decreasing amounts of template DNA, (4) the hypothesis that the parental longest uninterrupted stretch (LUS) is a better linear predictor of stutter ratio than the parent allele length, (5) the use of parental allele length as a predictor of shoulder ratio, and (6) the removal of non-systematic erroneous sequences using dynamic thresholds created by fitting the distribution of the non-systematic erroneous sequences...
February 3, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28182138/construct-validity-of-the-depression-and-somatic-symptoms-scale-evaluation-by-mokken-scale-analysis
#4
Ya-Hsin Chou, Chin-Pang Lee, Chia-Yih Liu, Ching-I Hung
OBJECTIVE: Previous studies of the Depression and Somatic Symptoms Scale (DSSS), a free scale, have been based on the classical test theory, and the construct validity and dimensionality of the DSSS are as yet uncertain. The aim of this study was to use Mokken scale analysis (MSA) to assess the dimensionality of the DSSS. METHODS: A sample of 214 psychiatric outpatients with mood and anxiety disorders were enrolled at a medical center in Taiwan (age: mean [SD] =38...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28168351/circulating-microparticles-and-the-risk-of-thromboembolic-events-in-egyptian-beta-thalassemia-patients
#5
Ilham Youssry, Nohair Soliman, Mona Ghamrawy, Rania Mohamed Samy, Amal Nasr, Mohamed Abdel Mohsen, Mohamed ElShahaat, Rayan Bou Fakhredin, Ali Taher
The presence of elevated numbers of circulating microparticles (MPs) has been hypothesized to be responsible for the occurrence of thromboembolic events (TEEs) in thalassemic patients. Our aim is to evaluate the presence and the thrombotic risk of circulating MPs in thalassemia patients and to determine the difference in MPs between β-thalassemia major (β-TM) and thalassemia intermedia (TI). The percentage of the annexin-labeled MPs, platelet-derived MPs (PMPs), erythrocyte-derived MPs (RMPs), and endothelial-derived MPs (EMPs) was measured by flow cytometry, in 87 thalassemia patients (39 β-TM and 48 TI)...
February 7, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28164307/how-to-quantify-microparticles-in-rbcs-a-validated-flow-cytometry-method-allows-the-detection-of-an-increase-in-microparticles-during-storage
#6
Clémentine Gamonet, Guillaume Mourey, Sophie Aupet, Sabéha Biichle, Régis Petitjean, Chrystelle Vidal, Aurore Pugin, Christian Naegelen, Pierre Tiberghien, Pascal Morel, Fanny Angelot-Delettre, Estelle Seilles, Philippe Saas, Laurent Bardiaux, Francine Garnache-Ottou
BACKGROUND: The procoagulant and proinflammatory microparticles (MPs) released during storage of packed red blood cells (pRBCs) can potentially modify transfusion benefits. A robust method to quantify MPs in pRBCs is needed to evaluate their impact in clinical trials. STUDY DESIGN AND METHODS: The objective was to validate the preanalytic conditions required to prepare pRBC supernatant as well as a method to quantify and evaluate MP variations over 42 days of pRBC storage...
February 5, 2017: Transfusion
https://www.readbyqxmd.com/read/28156669/a-novel-scoring-system-to-predict-survival-in-patients-with-advanced-pancreatic-adenocarcinoma-the-memorial-prognostic-score-mps
#7
Alison Wiesenthal, Andrew S Epstein, Junting Zheng, Jessica Goldberg, Jason Meadows, Eileen Mary O'Reilly, Paul A Glare
: 36 Background: A major limitation of prognostic tools such as the Eastern Cooperative Oncology Group (ECOG), Karnofsky, and Palliative Performance Scale is a reliance on subjective clinical assessment. An objective tool, the Glasgow Prognostic Score (GPS) is derived from C-reactive Protein (CRP) and albumin and has been validated in patients with operable and inoperable malignancies. One disadvantage of this tool is that CRP is not routinely measured in the United States. We examined if the Neutrophil-Lymphocyte Ratios (NLR) (Ahn, H...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156456/prevalence-of-myofascial-pain-syndrome-in-patients-with-incurable-cancer
#8
Junya Kinkawa, Aya Watanabe, Chie Watanabe, Tsukuru Chiba, Naoki Shimada, Keisuke Ariyoshi, Masanori Nojima, Satoru Iwase, Arinobu Tojo
: 97 Background: Myofascial pain syndrome (MPS) is a condition that involves skeletal muscles. It is caused by overload or disuse of muscles and is characterized by extreme tenderness in the muscles with taut bands. Treatment for MSP is different from that for cancer-related pain. Cancer patients have many factors that cause restriction of body movement and posture. Although cancer patients appear to demonstrate risk factors for MPS, its prevalence has not been reported in patients with incurable cancer...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28151904/comparison-between-ultrasound-guided-interfascial-pulsed-radiofrequency-and-ultrasound-guided-interfascial-block-with-local-anesthetic-in-myofascial-pain-syndrome-of-trapezius-muscle
#9
Ik Tae Cho, Yun Woo Cho, Sang Gyu Kwak, Min Cheol Chang
Myofascial pain syndrome (MPS) of the trapezius muscle (TM) is a frequently occurring musculoskeletal disorder. However, the treatment of MPS of the TM remains a challenge. We investigated the effects of ultrasound (US)-guided pulsed radiofrequency (PRF) stimulation on the interfascial area of the TM. In addition, we compared its effect with that of interfascial block (IFB) with 10 mL of 0.6% lidocaine on the interfascial area of the TM. Thirty-six patients with MPS of the TM were included and randomly assigned into 2 groups...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28150311/spherocytic-shift-of-red-blood-cells-during-storage-provides-a-quantitative-whole-cell-based-marker-of-the-storage-lesion
#10
Camille Roussel, Michaël Dussiot, Mickaël Marin, Alexandre Morel, Papa Alioune Ndour, Julien Duez, Caroline Le Van Kim, Olivier Hermine, Yves Colin, Pierre A Buffet, Pascal Amireault
BACKGROUND: Storage lesion may explain the rapid clearance of up to 25% of transfused red blood cells (RBCs) in recipients. Several alterations affect stored RBC but a quantitative, whole cell-based predictor of transfusion yield is lacking. Because RBCs with reduced surface area are retained by the spleen, we quantified changes in RBC dimensions during storage. STUDY DESIGN AND METHODS: Using imaging flow cytometry we observed the dimension and morphology of RBCs upon storage, along with that of conventional biochemical and mechanical markers of storage lesion...
February 1, 2017: Transfusion
https://www.readbyqxmd.com/read/28150116/subcutaneous-implantation-of%C3%A2-microencapsulated-cells-overexpressing-%C3%AE-l-iduronidase-for-mucopolysaccharidosis-type-i-treatment
#11
Valeska Lizzi Lagranha, Barbara Zambiasi Martinelli, Guilherme Baldo, Giuseppe Ávila Testa, Talita Giacomet de Carvalho, Roberto Giugliani, Ursula Matte
Mucopolysaccharidosis type I (MPS I) is caused by a deficiency of α-L-iduronidase (IDUA), resulting in accumulation of glycosaminoglycans (GAG) in lysosomes. Microencapsulation of recombinant cells is a promising gene/cell therapy approach that could overcome the limitations of the current available treatments. In the present study we produced alginate-poly-L-lysine-alginate (APA) microcapsules containing recombinant cells overexpressing IDUA, which were implanted in the subcutaneous space of MPS I mice in order to evaluate their potential effect as a treatment for this disease...
March 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28148395/tissue-factor-factor-viia-complex-triggers-protease-activated-receptor-2-dependent-growth-factor-release-and-migration-in-ovarian-cancer
#12
Alice Chanakira, Pamela R Westmark, Irene M Ong, John P Sheehan
OBJECTIVE: Enhanced tissue factor (TF) expression in epithelial ovarian cancer (EOC) is associated with aggressive disease. Our objective was to evaluate the role of the TF-factor VIIa-protease-activated receptor-2 (PAR-2) pathway in human EOC. METHODS: TCGA RNAseq data from EOC databases were analyzed for PAR expression. Cell and microparticle (MP) associated TF protein expression (Western blot) and MP-associated coagulant activity were determined in human EOC (SKOV-3, OVCAR-3 and CaOV-3) and control cell lines...
January 29, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28145222/protective-immunity-against-toxoplasmosis-in-mice-induced-by-single-dose-immunization-with-rsag1-2-protein-released-from-poly-lactide-co-glycolide-microparticles
#13
Shu-Chun Chuang, Yao-Chi Chung, Chung-Da Yang
Triphasic sustained release of tachyzoite chimeric protein, rSAG1/2, from poly(lactide-co-glycolide) (PLG)-encapsulated rSAG1/2 (PLG-rSAG1/2) microparticles (MPs) is a promising characteristic for developing a single-dose vaccine against Toxoplasma gondii in domestic animals. In the present study, we aimed to evaluate whether single immunization with PLG-rSAG1/2 MPs in BALB/c mice would achieve effective immunity and protection against T. gondii. Peritoneal immunization of mice with a single dose of PLG-rSAG1/2 MPs enhanced serum IgG titers and lymphocyte proliferation in a triphasic model over a long 12-week period...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28139111/relationship-between-ice-hockey-specific-complex-test-and-maximal-strength-aerobic-capacity-and-postural-regulation-in-professional-players
#14
René Schwesig, Souhail Hermassi, Sebastian Edelmann, Ulrike Thorhauer, Stephan Schulze, Georg Fieseler, Karl S Delank, Roy J Shephard, Mohamed S Chelly
BACKGROUND: We aimed to examine the validity of an ice hockey-specific complex test (IHCT) and nonspecific off-ice tests for sports performance. METHODS: Eighteen professional athletes (27.4 ± 6.0 years) underwent the IHCT, maximal strength squat tests, an endurance cycling test (PWC 170) and posturography during in the first week of the pre-seasonal training. The IHCT included parameters of load (e.g., 10m and 30m sprint, transition and weave agility without and with puck, slap and wrist shots before and after the test)...
January 31, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28137635/in-silico-analysis-of-the-biomechanical-stability-of-commercially-pure-ti-and-ti-15mo-plates-for-the-treatment-of-mandibular-angle-fracture
#15
Satoshi Yamaguchi, Rodolfo B Anchieta, Fernando P S Guastaldi, Nick Tovar, Daisuke Tawara, Satoshi Imazato, Paulo G Coelho
PURPOSE: To investigate the influence of different materials and fixation methods on maximum principal stress (MPS) and displacement in reconstruction plates using in silico 3-dimensional finite element analysis (3D-FEA). MATERIALS AND METHODS: Computer-assisted designed (CAD) models of the mandible and teeth were constructed. Champy and AO/ASIF plates and fixation screws were designed with CAD software. 3D-FEA was performed by image-based CAE software. Maximum and minimum values of biomechanical stability, MPS, and displacement distribution were compared in Champy and AO/ASIF plates made from commercially pure titanium grade 2 (cp-Ti) and a titanium-and-molybdenum (14...
January 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28130333/can-endothelial-hemoglobin-alpha-regulate-nitric-oxide-vasodilatory-signaling
#16
Jaimit Parikh, Adam Kapela, Nikolaos M Tsoukias
We utilized mathematical modeling to investigate nitric oxide (NO)-dependent vasodilatory signaling in the arteriolar wall. Detailed continuum cellular models of calcium (Ca(2+)) dynamics and membrane electrophysiology in smooth muscle (SMC) and endothelial cells (EC) were coupled with models of NO signaling and biotransport in an arteriole. We use this theoretical approach to examine the role of endothelial hemoglobin alpha (Hbα) as a modulator of NO-mediated myoendothelial feedback as previously suggested in Straub al...
January 27, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28118425/entropy-of-masseter-muscle-pain-sensitivity-a-new-technique-for-pain-assessment
#17
Eduardo E Castrillon, Fernando G Exposto, Hitoshi Sato, Tomohiro Tanosoto, Taro Arima, Lene Baad-Hansen, Peter Svensson
AIMS: To test whether manipulation of mechanical pain sensitivity (MPS) of the masseter muscle is reflected in quantitative measures of entropy. METHODS: In a randomized, single-blinded, placebo-controlled design, 20 healthy volunteers had glutamate, lidocaine, and isotonic saline injected into the masseter muscle. Self-assessed pain intensity on a numeric rating scale (NRS) was evaluated up to 10 minutes following the injection, and MPS was evaluated after application (at 5 minutes and 30 minutes) of three different forces (0...
January 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28098417/delivery-of-anesthesia-for-children-with-mucopolysaccharidosis-type-iii-sanfilippo-syndrome-a-review-of-86-anesthetics
#18
Marc A Cohen, Grant M Stuart
BACKGROUND: Sanfilippo syndrome (MPS III) is rare, with 97 cases in the United Kingdom between 1988 and 1998. Mucopolysaccharide infiltration of tissues in mucopolysaccharidosis (MPS) causes multi-systemic pathology including difficult airways and cardiac disease. Published anesthesia case reviews of Sanfilippo syndrome have included limited numbers of patients to date. AIM: To identify the perioperative management and complications of anesthesia in children with mucopolysaccharidosis Type III at Great Ormond Street Hospital...
January 18, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28096000/effects-of-oral-care-with-glutamine-in-preventing-ventilator-associated-pneumonia-in-neurosurgical-intensive-care-unit-patients
#19
Hatice Kaya, Yüksel Turan, Yusuf Tunalı, Gülsün Özdemir Aydın, Neslihan Yüce, Şengül Gürbüz, Keziban Tosun
PURPOSE: The study was designed as a randomized, controlled, experimental study aiming to determine the effects of oral care with glutamine in preventing ventilator-associated pneumonia in patients admitted to neurosurgical intensive care unit. METHODS: The universe consisted of patients who are admitted to neurosurgical intensive care unit between January 2014 and August 2015, while the sample consisted of 88 patients who fulfilled the inclusion criteria and were randomly selected...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28089550/assessment-of-microplastic-sorbed-contaminant-bioavailability-through-analysis-of-biomarker-gene-expression-in-larval-zebrafish
#20
Victoria A Sleight, Adil Bakir, Richard C Thompson, Theodore B Henry
Microplastics (MPs) are prevalent in marine ecosystems. Because toxicants (termed here "co-contaminants") can sorb to MPs, there is potential for MPs to alter co-contaminant bioavailability. Our objective was to demonstrate sorption of two co-contaminants with different physicochemistries [phenanthrene (Phe), log10Kow=4.57; and 17α-ethinylestradiol (EE2), log10Kow=3.67] to MPs; and assess whether co-contaminant bioavailability was increased after MP settlement. Bioavailability was indicated by gene expression in larval zebrafish...
January 12, 2017: Marine Pollution Bulletin
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