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https://www.readbyqxmd.com/read/27909712/myocardial-perfusion-spect-2015-in-germany-results-of-the-7th-survey
#1
Oliver Lindner, Wolfgang Burchert, Wolfgang Schäfer, Marcus Hacker
AIM: The working group Cardiovascular Nuclear Medicine of the German Society of Nuclear Medicine presents the results of the 7th survey of myocardial perfusion SPECT (MPS) of the reporting year 2015. METHOD: 268 questionnaires (173 practices [PR], 67 hospitals [HO], 28 university hospitals [UH]) were evaluated. Results of the last survey from 2012 are set in squared brackets. RESULTS: MPS of 121 939 [105 941] patients were reported. 98 % [95 %] of all MPS were performed with Tc-99m radiopharmaceuticals and 2 % [5 %] with Tl-201...
December 2, 2016: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/27904658/circulating-microparticles-enhanced-rat-vascular-wall-remodeling-following-endothelial-denudation
#2
Fan-Yen Lee, Hung-I Lu, Han-Tan Chai, Jiunn-Jye Sheu, Yi-Ling Chen, Tein-Hung Huang, Gour-Shenq Kao, Sheng-Yi Chen, Sheng-Ying Chung, Pei-Hsun Sung, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
This study tested the hypothesis that circulating microparticles (MPs) exacerbated vascular wall (VW) remodeling after endothelial denudation by 0.014 wire in a rat model. Adult male Sprague Dawley rats (n = 40) were equally categorized into group 1 [sham-control (SC); 3.0 mL saline intravenous injection], group 2 [SC + intravenous MPs (1.0 × 10(7)) derived from patients with carotid artery stenosis (CAS)], group 3 [femoral arterial endothelial denudation (FAED)], group 4 (FAED + MPs derived from healthy subjects), and group 5 (FAED + CAS-derived MPs)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27903231/new-analogues-of-mycophenolic-acid
#3
Agnieszka Głowacka, Michal Prejs, Grzegorz Cholewinski, Krystyna Dzierzbicka
Mycophenolic acid (MPA) possesses antibacterial, antifungal, antiviral, immunosuppressive and anticancer properties. It is a non-competitive and reversible inhibitor of dehydrogenase inosine-5'-monophosphate (IMPDH) [1,2]. This compound belongs to the immunosuppressive drugs used for the prevention of both acute and chronic transplant rejection [3]. Until now clinically have been used two derivatives of MPA: mycophenolate mofetil (MMF, CellCept) and mycophenolate sodium (MPS, Myfortic). They cause, similar to MPA, although at lower degree, the side effects such as vomiting, abdominal pain, diarrhea, nausea, gastrointestinal, urogenital tract, blood or nervous system disorders...
November 29, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27898598/pharmacokinetics-of-mycophenolic-acid-and-dose-optimization-in-children-after-intestinal-transplantation
#4
Caroline Barau, Antonio Mellos, Stéphanie Chhun, Florence Lacaille, Valérie Furlan
BACKGROUND: Mycophenolate mofetil (MMF) or enteric-coated mycophenolate sodium (MPS) are now commonly used in pediatric intestinal transplantation (Tx), but to date, no clear recommendations regarding the dosing regimen have been made in this population. The aim of this study was to determine the MMF/MPS dosage required to achieve an area under the plasma concentration-time curve from 0 to 12 hours (AUC0-12) for mycophenolic acid (MPA) greater than 30 mg.h/L in children after intestinal transplantation...
November 28, 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27894723/plastic-debris-and-microplastics-along-the-beaches-of-the-strait-of-hormuz-persian-gulf
#5
Abolfazl Naji, Zinat Esmaili, Farhan R Khan
Currently little is known about the prevalence of plastics and microplastics (MPs) in the Persian Gulf. Five sampling stations were selected along the Strait of Hormuz (Iran) that exhibited different levels of industrialization and urbanization, and included a marine protected area. Debris was observed and sediments were collected for MPs extraction via fluidization/floatation methodology. The order of MP abundance (par/kg) generally reflected the level of anthropogenic activity: Bostanu (1258±291)>Gorsozan (122±23)>Khor-e-Yekshabeh (26±6)>Suru (14±4)>Khor-e-Azini (2±1)...
November 25, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27882161/potential-diagnostic-role-of-diffusion-tensor-imaging-in-early-stage-osteonecrosis-of-the-femoral-head
#6
Hongwei Min, Feng Xu, Rui Gu, Xinzuo Han, Anqing Wang, Kemin Liu
The present study aimed to explore the potential diagnostic role of diffusion tensor magnetic resonance imaging (DTI) in the early stage of modified corticosteroid-induced osteonecrosis of the femoral head (ONFH). A total of 20 beagles were randomly classified (1:1) into either an experimental group (LM), which were intramuscularly injected with lipopolysaccharide (LPS) and methylprednisolone (MPS) on three consecutive days, or control (CON) group, which were injected with saline. Magnetic resonance imaging (MRI) and DTI were performed at pre-induction and 8 and 12 weeks post-induction...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27876528/the-impact-of-lens-care-solutions-on-corneal-epithelial-changes-during-daily-silicone-hydrogel-contact-lens-wear-as-measured-by-in-vivo-confocal-microscopy
#7
Xiaolin Zhang, Christine Marchetti, Jessica Lee, Yan Sun, Sara Debanne, Ying Jiang, Jami Kern, Mark Harrod, Beth Ann Benetz, Eric Pearlman, Loretta Szczotka-Flynn
PURPOSE: To assess corneal epithelial microstructure via confocal microscopy and determine if cellular changes are associated with lens care solutions during daily wear of silicone hydrogel contact lenses. METHODS: Corneal in vivo confocal microscopy with the Nidek ConfoScan4 was performed at baseline and after 5 months of lotrafilcon A daily contact lens wear. Enrolled participants were randomized to use either a polyhexamethylene biguanide (PHMB) preserved multipurpose care solution (MPS) or a peroxide based solution system...
November 19, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27873516/cyclosporine-sparing-effect-of-enteric-coated-mycophenolate-sodium-in-de-novo-kidney-transplantation
#8
Su Hyung Lee, Jae Berm Park, Chang Kwon Oh, Myoung Soo Kim, Sung Joo Kim, Jongwon Ha
PURPOSE: The increased tolerability of enteric-coated mycophenolate sodium (EC-MPS), compared to mycophenolate mofetil, among kidney transplant recipients has the potential to facilitate cyclosporine (CsA) minimization. Therefore, a prospective trial to determine the optimum EC-MPS dose in CsA-based immunosuppression regimens is necessary. MATERIALS AND METHODS: A comparative, parallel, randomized, open-label study was performed for 140 patients from four centers to compare the efficacy and tolerability of low dose CsA with standard dose EC-MPS (the investigational group) versus standard dose CsA with low dose EC-MPS (the control group) for six months in de novo kidney transplant recipients...
January 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27834867/the-ionospheric-scintillation-effects-on-the-beidou-signal-receiver
#9
Zhijun He, Hongbo Zhao, Wenquan Feng
Irregularities in the Earth's ionosphere can make the amplitude and phase of radio signals fluctuate rapidly, which is known as ionospheric scintillation. Severe ionospheric scintillation could affect the performance of the Global Navigation Satellite System (GNSS). Currently, the Multiple Phase Screen (MPS) technique is widely used in solving problems caused by weak and strong scintillations. Considering that Southern China is mainly located in the area where moderate and intense scintillation occur frequently, this paper built a model based on the MPS technique and discussed the scintillation impacts on China's BeiDou navigation system...
November 9, 2016: Sensors
https://www.readbyqxmd.com/read/27826022/functional-characterization-of-arylsulfatase-b-mutations-in-indian-patients-with-maroteaux-lamy-syndrome-mucopolysaccharidosis-type-vi
#10
Anusha Uttarilli, Divya Pasumarthi, Prajnya Ranganath, Ashwin B Dalal
MPS VI is an autosomal recessive disorder which occurs due to the deficiency of N-acetyl galactosamine-4-sulfatase (Arylsulfatase B - ARSB) involved in catabolism of dermatan sulfate resulting from disease-causing variations in the ARSB gene. Human Gene Mutation Database (HGMD) search revealed 200 different mutations in ARSB worldwide. In the present study we carried out molecular and functional analyses to characterize the mutations reported by us in Indian population. Mutation analysis of 19 MPS VI patients revealed presence of a total of 15 different mutations of which twelve were novel [p...
November 5, 2016: Gene
https://www.readbyqxmd.com/read/27825773/four-novel-mutations-in-the-n-acetylgalactosamine-6-sulfate-sulfatase-gene-among-egyptian-patients-with-morquio-a-disease
#11
Ekram M Fateen, Hanan Abd El Mawgoud, Noura R Eissa, Mona M Ibrahim, Mona S Aglan, Mona L Essawi
Morquio A disease (Mucopolysaccharidosis IVA, MPS IVA) is an autosomal recessive lysosomal storage disorder caused by deficient activity of the enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS) encoded by the GALNS gene. This deficiency leads to a decreased ability to degrade the glycosaminoglycans (GAGs) keratan sulfate and chondroitin 6-sulfate, thereby causing their accumulation within the lysosomes and consequently prominent skeletal and visceral abnormalities. Clinical evaluation and biochemical GALNS enzyme activity determination were carried out for the patients from four unrelated Egyptian families...
November 4, 2016: Gene
https://www.readbyqxmd.com/read/27810645/pre-instillation-of-tumor-microparticles-enhances-intravesical-chemotherapy-of-nonmuscle-invasive-bladder-cancer-through-a-lysosomal-pathway
#12
Xun Jin, Jingwei Ma, Xiaoyu Liang, Ke Tang, Yuying Liu, Xiaonan Yin, Yi Zhang, Huafeng Zhang, Pingwei Xu, Degao Chen, Tianzhen Zhang, Jinzhi Lu, Zhuowei Hu, Xiaofeng Qin, Xiaoyong Zeng, Longcheng Li, Bo Huang
Nonmuscle-invasive bladder cancer (NMIBC) is treated with transurethral resection followed by intravesical chemotherapy. However, drug-resistant tumorigenic cells cannot be eliminated, leading to half of the treated cancers recur with increased stage and grade. Innovative approaches to enhance drug sensitivity and eradicate tumorigenic cells in NMIBC treatment are urgently needed. Here, we show that pre-instillation of tumor cell-derived microparticles (T-MP) as natural biomaterials markedly enhance the inhibitory effects of intravesical chemotherapy on growth and hematuria occurrence of orthotropic bladder cancer in mice...
October 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/27802066/analgesic-effect-of-botulinum-toxin-a-in-myofascial-pain-syndrome-patients-previously-treated-with-local-infiltration-of-anesthetic-and-steroids
#13
Joaquín Cartagena-Sevilla, María R García-Fernández, Juan P Vicente-Villena
The purpose of this study was to evaluate the analgesic effect of botulinum toxin A (BoNTA) injections in patients with myofascial pain syndrome (MPS) who were previously treated with the local infiltration of anesthetic and steroids (LIAS). The study included a retrospective phase and a longitudinal open-label prospective phase, which were conducted on consecutive patients with MPS previously treated with the local infiltration of anesthetic (levobupivacaíne 0.25%) and steroids (triamcinolone 40 mg). Eligible patients were treated with a single intramuscular injection of BoNTA (Botox; Allergan, Inc...
November 1, 2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/27797586/novel-mutations-including-a-large-deletion-in-the-arsb-gene-causing-mucopolysaccharidosis-type-vi
#14
Chupong Ittiwut, Sukanya Boonbuamas, Chalurmpon Srichomthong, Rungnapa Ittiwut, Kanya Suphapeetiporn, Vorasuk Shotelersuk
OBJECTIVE: Mucopolysaccharidosis type VI (MPS VI; Maroteaux-Lamy syndrome), a rare autosomal recessive lysosomal storage disease, is caused by mutations in the N-acetylgalactosamine-4-sulfatase (arylsulfatase B, or ARSB) gene, resulting in a deficiency of ARSB activity. This study aimed to characterize the clinical and molecular features of four unrelated Thai patients with MPS VI. Two were products of consanguineous marriages. MATERIALS AND METHODS: The diagnosis was confirmed by biochemical and genetic tests...
October 31, 2016: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27794412/prediction-of-distant-recurrence-in-resected-stage-i-and-ii-lung-adenocarcinoma
#15
Beatrice Aramini, Christian Casali, Alessandro Stefani, Stefania Bettelli, Susanne Wagner, Zaina Sangale, Elisha Hughes, Jerry S Lanchbury, Antonino Maiorana, Uliano Morandi
OBJECTIVES: Optimal procedures for adjuvant treatment and post-surgical surveillance of resected non-small-cell lung cancer remain under discussion. Pathological features are the main determinant of follow-up therapy but have limited ability to identify patients at risk of recurrence. Increasingly, molecular markers are incorporated into clinical decision-making, including measures of tumor growth. The CCP score is a quantitative, molecular measure of proliferation derived from the RNA expression of 31 cell cycle genes and a component of the molecular prognostic score (mPS)...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/27792124/erythrocyte-derived-microparticles-activate-pulmonary-endothelial-cells-in-a-murine-model-of-transfusion
#16
Alex L Chang, Young Kim, Aaron P Seitz, Rebecca M Schuster, Alex B Lentsch, Timothy A Pritts
Erythrocyte-derived microparticles (MPs) are sub-micrometer, biologically active vesicles shed by red blood cells as part of the biochemical changes that occur during storage. We hypothesized that MPs from stored red blood cells would activate endothelial cells. MPs from aged murine packed red blood cells (pRBCs) were isolated and used to treat confluent layers of cultured endothelial cells. Endothelial expression of leukocyte adhesion molecules, ELAM-1 and ICAM-1, and inflammatory mediator, IL-6, were evaluated at 0...
October 27, 2016: Shock
https://www.readbyqxmd.com/read/27781422/evaluation-of-area-under-the-curve-of-enteric-coated-mycophenolate-sodium-by-limited-sampling-strategy-in-chinese-kidney-transplant-recipients%C3%A2
#17
Hongfeng Huang, Xi Yao, Jianyong Wu, Wenhan Peng, Jianghua Chen
AIMS: To investigate the area under the curve (AUC) of mycophenolic acid (MPA) in adult Chinese renal allograft recipients receiving concomitant enteric-coated mycophenolate sodium (EC-MPS) and cyclosporine (CsA) during the early post-transplant phase and to develop optimal model equations for estimation of the MPA area under the plasma concentration-time curve from 0 to 12 hours (AUC0-12h) using a limited-sampling strategy (LSS). METHODS: The present study enrolled 24 Chinese renal recipients treated with EC-MPS, CsA, and corticosteroid, from whom 24 serial blood samples were collected over 12 hours...
October 26, 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27766958/more-comprehensive-forensic-genetic-marker-analyses-for-accurate-human-remains-identification-using-massively-parallel-dna-sequencing
#18
Angie D Ambers, Jennifer D Churchill, Jonathan L King, Monika Stoljarova, Harrell Gill-King, Mourad Assidi, Muhammad Abu-Elmagd, Abdelbaset Buhmeida, Bruce Budowle
BACKGROUND: Although the primary objective of forensic DNA analyses of unidentified human remains is positive identification, cases involving historical or archaeological skeletal remains often lack reference samples for comparison. Massively parallel sequencing (MPS) offers an opportunity to provide biometric data in such cases, and these cases provide valuable data on the feasibility of applying MPS for characterization of modern forensic casework samples. In this study, MPS was used to characterize 140-year-old human skeletal remains discovered at a historical site in Deadwood, South Dakota, United States...
October 17, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27760463/mycobacterium-tuberculosis-infection-manipulates-the-glycosylation-machinery-and-the-n-glycoproteome-of-human-macrophages-and-their-microparticles
#19
Nathan J Hare, Ling Y Lee, Ian Loke, Warwick J Britton, Bernadette M Saunders, Morten Thaysen-Andersen
Tuberculosis (TB) remains a prevalent and lethal infectious disease. The glycobiology associated with Mycobacterium tuberculosis infection of front-line alveolar macrophages is still unresolved. Herein, we investigated the regulation of protein N-glycosylation in human macrophages and their secreted microparticles (MPs) used for intercellular communication upon M. tb infection. LC-MS/MS-based proteomics and glycomics were performed to monitor the regulation of glycosylation enzymes and receptors and the N-glycome in in vitro-differentiated macrophages and in isolated MPs upon M...
October 19, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27749498/correlations-of-in-vitro-assays-for-assessing-cytotoxicity-and-biocompatibility-of-contact-lens-multipurpose-solutions
#20
Ling C Huang, Mercedes Salvador-Silva, Ronika S Leang
OBJECTIVES: To demonstrate correlations among in vitro assays used for assessing cytotoxicity of contact lens multipurpose solution (MPS) and propose the use of multiple assays as a part of preclinical evaluation for MPS biocompatibility assessment. METHODS: The effect of four different MPSs on cell cytotoxicity, metabolic activity, and membrane integrity was performed by evaluating toxicity, expression of tight junction protein zonula occludens-1, and transepithelial electrical resistance in human corneal epithelial cells and Chinese hamster fibroblasts cells...
October 3, 2016: Eye & Contact Lens
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