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https://www.readbyqxmd.com/read/29348164/ifcc-working-group-recommendations-for-assessing-commutability-part-3-using-the-calibration-effectiveness-of-a-reference-material
#1
Jeffrey R Budd, Cas Weykamp, Robert Rej, Finlay MacKenzie, Ferruccio Ceriotti, Neil Greenberg, Johanna E Camara, Heinz Schimmel, Hubert W Vesper, Thomas Keller, Vincent Delatour, Mauro Panteghini, Chris Burns, W Greg Miller
A process is described to assess the commutability of a reference material (RM) intended for use as a calibrator based on its ability to fulfill its intended use in a calibration traceability scheme to produce equivalent clinical sample (CS) results among different measurement procedures (MPs) for the same measurand. Three sources of systematic error are elucidated in the context of creating the calibration model for translating MP signals to measurand amounts: calibration fit, calibrator level trueness, and commutability...
January 18, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29348163/ifcc-working-group-recommendations-for-assessing-commutability-part-1-general-experimental-design
#2
W Greg Miller, Heinz Schimmel, Robert Rej, Neil Greenberg, Ferruccio Ceriotti, Chris Burns, Jeffrey R Budd, Cas Weykamp, Vincent Delatour, Göran Nilsson, Finlay MacKenzie, Mauro Panteghini, Thomas Keller, Johanna E Camara, Ingrid Zegers, Hubert W Vesper
Commutability is a property of a reference material (RM) that relates to the closeness of agreement between results for an RM and results for clinical samples (CSs) when measured by ≥2 measurement procedures (MPs). Commutability of RMs used in a calibration traceability scheme is an essential property for them to be fit for purpose. Similarly, commutability of trueness controls or external quality assessment samples is essential when those materials are used to assess trueness of results for CSs. This report is part 1 of a 3-part series describing how to assess commutability of RMs...
January 18, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29347354/coarsening-and-pattern-formation-during-true-morphological-phase-separation-in-unstable-thin-films-under-gravity
#3
Avanish Kumar, Chaitanya Narayanam, Rajesh Khanna, Sanjay Puri
We address in detail the problem of true morphological phase separation (MPS) in three-dimensional or (2+1)-dimensional unstable thin liquid films (>100nm) under the influence of gravity. The free-energy functionals of these films are asymmetric and show two points of common tangency, which facilitates the formation of two equilibrium phases. Three distinct patterns formed by relative preponderance of these phases are clearly identified in "true MPS". Asymmetricity induces two different pathways of pattern formation, viz...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29326871/quantification-of-the-enzyme-activities-of-iduronate-2-sulfatase-n-acetylgalactosamine-6-sulfatase-and-n-acetylgalactosamine-4-sulfatase-using-liquid-chromatography-tandem-mass-spectrometry
#4
Ryuichi Mashima, Mari Ohira, Torayuki Okuyama, Akiya Tatsumi
Mucopolysaccharidosis (MPS) is a genetic disorder characterized by the accumulation of glycosaminoglycans in the body. Of the multiple MPS disease subtypes, several are caused by defects in sulfatases. Specifically, a defect in iduronate-2-sulfatase (ID2S) leads to MPS II, whereas N-acetylgalactosamine-6-sulfatase (GALN) and N-acetylgalactosamine-4-sulfatase (ARSB) defects relate to MPS IVA and MPS VI, respectively. A previous study reported a combined assay for these three disorders in a 96-well plate using a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based technique (Kumar et al...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29313030/poly-2-propylacrylic-acid-poly-lactic-co-glycolic-acid-blend-microparticles-as-a-targeted-antigen-delivery-system-to-direct-either-cd4-or-cd8-t-cell-activation
#5
Lirong Yang, Evelyn Bracho-Sanchez, Lawrence P Fernando, Jamal S Lewis, Matthew R Carstens, Craig L Duvall, Benjamin G Keselowsky
Poly(lactic-co-glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner. Micron-sized PLGA MPs are readily phagocytosed by antigen presenting cells, and localized to endosomes. Due to low pH and digestive enzymes, encapsulated protein cargo is largely degraded and processed in endosomes for MHC-II loading and presentation to CD4+ T cells, with very little antigen delivered into the cytosol, limiting MHC-I antigenic loading and presentation to CD8+ T cells...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29291076/synthesis-and-applications-of-mans-poly-mma-co-ba-nanocomposite-latex-by-miniemulsion-polymerization
#6
Sheng Gong, Huayao Chen, Xinhua Zhou, Sundaram Gunasekaran
We have synthesized core-shell structured 3-methacryloxypropyltrimethoxysilane (MPS) functionalized antimony-doped tin oxide nanoparticles (MANs)-poly(methyl methacrylate-co-butyl acrylate) (PMMA-co-BA, PMB) nanocomposite latex particles via miniemulsion polymerization method. Polymerizable anionic surfactant DNS-86 (allyloxy polyoxyethylene(10) nonyl ammonium sulfate) was first introduced to synthesize core-shell nanocomposite. The morphologies of synthesized MANs and MANs/PMB latex nanocomposite particles were studied with transmission electron microscopy, which revealed particles, on average 70 nm in size, with a core-shell structure...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29287333/methoxypyrazines-biosynthesis-and-metabolism-in-grape-a-review
#7
REVIEW
Yujuan Lei, Sha Xie, Xueqiang Guan, Changzheng Song, Zhenwen Zhang, Jiangfei Meng
This review summarizes research on the discovery, biosynthesis, accumulation, transport, and metabolism of 3-alkyl-2-methoxypyrazines (MPs) in grape. The MPs are a family of potent volatile compounds distributed throughout biological kingdoms. These compounds impart herbaceous/green/vegetal sensory attributes to certain varieties of wine. Generally, high levels of MPs in wine are derived mainly from the corresponding grapes. Although two pathways for MPs biosynthesis have been proposed, only the final step and the enzymes that catalyze it has been confirmed in grape, and the metabolic intermediates and key enzymes involved in other steps are still unknown...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29282638/efficacy-and-safety-of-lumen-apposing-metal-stents-in-management-of-pancreatic-fluid-collections-are-they-better-than-plastic-stents-a-systematic-review-and-meta-analysis
#8
REVIEW
Tariq Hammad, Muhammad Ali Khan, Yaseen Alastal, Wade Lee, Ali Nawras, Mohammad Kashif Ismail, Michel Kahaleh
BACKGROUND AND AIMS: Endoscopic ultrasound (EUS)-guided transmural drainage has been increasingly utilized as a first-line therapeutic modality for drainage of pancreatic fluid collections (PFC). Recently, lumen-apposing metal stents (LAMS) have been utilized for management of PFCs. We conducted a systematic review and meta-analysis to evaluate the cumulative efficacy and safety of LAMS in the management of PFC (primary outcome). We also compared the efficacy and safety of LAMS with multiple plastic stents (MPS) in the management of PFC (secondary outcome)...
December 27, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29279160/preoperative-assessment-of-pleural-adhesion-by-four-dimensional-ultra-low-dose-computed-tomography-4d-uldct-with-adaptive-iterative-dose-reduction-using-three-dimensional-processing-aidr-3d
#9
Masayuki Hashimoto, Yukihiro Nagatani, Yasuhiko Oshio, Norihisa Nitta, Tsuneo Yamashiro, Shinsuke Tsukagoshi, Noritoshi Ushio, Masayuki Mayumi, Tatsuya Kimoto, Tomoyuki Igarashi, Makoto Yoshigoe, Kyohei Iwai, Koki Tanaka, Shigetaka Sato, Akinaga Sonoda, Hideji Otani, Kiyoshi Murata, Jun Hanaoka
PURPOSE: To assess the feasibility of Four-Dimensional Ultra-Low-Dose Computed Tomography (4D-ULDCT) for distinguishing pleural aspects with localized pleural adhesion (LPA) from those without. METHODS: Twenty-seven patients underwent 4D-ULDCT during a single respiration with a 16cm-coverage of the body axis. The presence and severity of LPA was confirmed by their intraoperative thoracoscopic findings. A point on the pleura and a corresponding point on the outer edge of the costal bone were placed in identical axial planes at end-inspiration...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29276957/microplastics-contamination-in-molluscs-from-the-northern-part-of-the-persian-gulf
#10
Abolfazl Naji, Marzieh Nuri, A Dick Vethaak
Microplastics (MPs) are well-known emerging contaminants in the marine environment. A key route by which MPs can directly affect marine life is through ingestion. The objective of the present study was to evaluate the occurrence of MPs in marine life and seafood for human consumption in the Persian Gulf. We conducted a whole body analysis of MP (between 10 and 5000 μm in diameter) abundance in five species of molluscs with different feeding strategies, including both gastropods and bivalves from the littoral zone of the Iranian coast of the Persian Gulf...
December 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29248359/impact-of-long-term-elosulfase-alfa-on-activities-of-daily-living-in-patients-with-morquio-a-syndrome-in-an-open-label-multi-center-phase-3-extension-study
#11
Christian J Hendriksz, Rossella Parini, Moeenaldeen D AlSayed, Julian Raiman, Roberto Giugliani, John J Mitchell, Barbara K Burton, Norberto Guelbert, Fiona J Stewart, Derralynn A Hughes, Robert Matousek, Sara M Hawley, Celeste Decker, Paul R Harmatz
BACKGROUND: Long-term safety and efficacy of elosulfase alfa enzyme replacement therapy (ERT) were assessed in 173 patients with Morquio A syndrome (mucopolysaccharidosis IVA) in a 96-week, open-label, multi-center, phase 3 extension study (MOR-005) of the pivotal 24-week, placebo-controlled study (MOR-004). Changes in efficacy endpoints were evaluated over 120weeks, from MOR-004 baseline to MOR-005 week 96. We report the impact of ERT on activities of daily living (ADL) across three domains (mobility, self-care, and caregiver-assistance), as assessed by the Mucopolysaccharidosis Health Assessment Questionnaire (MPS-HAQ) after 72 and 120weeks or approximately 1 and 2years...
December 5, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29235998/enhanced-degradation-of-micropollutants-by-zero-valent-aluminum-activated-persulfate-assessment-of-toxicity-and-genotoxic-activity
#12
T Olmez-Hanci, I Arslan-Alaton, M Doğan, S Khoei, H Fakhri, G Korkmaz
Advanced oxidation of the aqueous Triton™ X-45 (TX-45), iopamidol (IOPA), ciprofloxacin (CIP) and bisphenol A (BPA) solutions via activation of persulfate (PS) with zero-valent aluminum (ZVA) was investigated. The study aimed at assessing the effectiveness of the PS/ZVA process in terms of target micropollutants (MPs) and toxicity abatements in raw surface water (RSW) and distilled water (DW). TX-45, CIP and BPA were completely degraded after 90-minute, 120-minute and 40-minute treatment, respectively, with PS/ZVA in DW, whereas 95% IOPA removal was achieved after 120-minute (MPs = 2 mg/L; ZVA = 1 g/L; PS = 0...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235046/efficiency-of-nitrogen-metabolism-in-beef-cattle-grazing-pasture-and-supplemented-with-different-protein-levels-in-the-rainy-season
#13
Renata Pereira da Silva-Marques, Joanis Tilemahos Zervoudakis, Luciana Keiko Hatamoto-Zervoudakis, Pedro Ivo José Lopes da Rosa E Silva, Núbia Bezerra do Nascimento Matos, Andresa Lazzarotto Feliciano, Rones Goulart de Paula Júnior, Luciano da Silva Cabral
Supplementation of animals in the rainy season is essential to maximise weight gain. Thus, the objective was to evaluate the effects of supplementation with low-, medium- and high-protein levels on nutritional parameters of grazing beef cattle in the rainy season. Eight rumen-cannulated Nellore bulls (437 kg body weight) were used in a 4 × 4 double Latin square design with four supplements and four experimental periods. The treatments were mineral supplement (ad libitum) and supplements with low-protein (LPSU), medium-protein (MPS) and high-protein (HPS) levels, providing 106, 408 and 601 g/day of crude protein (CP), respectively...
December 12, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29219321/sheta2-dry-powder-aerosols-for-tuberculosis-formulation-design-and-optimization-using-quality-by-design
#14
Mariam Ibrahim, Manolya Kukut Hatipoglu, Lucila Garcia-Contreras
Tuberculosis (TB) is a life threatening pulmonary infection caused by Mycobacterium tuberculosis (MTB). Current treatments are complex, lengthy and associated with severe side effects that decrease patient compliance and increase the probability of the emergence of drug resistant strains. Thus, more effective drugs with little to no side effects are needed to diversify the armamentarium against the global TB epidemic. SHetA2, an anticancer compound with null toxicity at doses much higher than the effective dose, was recently discovered to be active against MTB...
December 8, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29211120/cell-derived-microparticles-in-gingival-crevicular-fluid-from-periodontitis-patients-with-type-2-diabetes
#15
Carlos Marcelo Figueredo, Ronaldo Lira, Manuela Rubim Sete, Ricardo Guimarães Fischer
Cell-derived microparticles (MPs) have been described as vital contributors to the inflammatory process. However, its role in the periodontal disease pathogenesis remains unclear. Therefore, we aimed to detect the presence neutrophil (CD66b+) and platelet (CD41b+) derived microparticles in gingival crevicular fluid from individuals having periodontitis aggravated by type 2 diabetes. Twelve patients (56.2 ±7.2 yrs) with severe form of chronic periodontitis aggravated by type 2 diabetes were included. Clinical and metabolic data were gathered...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29198892/rtb-lectin-mediated-delivery-of-lysosomal-%C3%AE-l-iduronidase-mitigates-disease-manifestations-systemically-including-the-central-nervous-system
#16
Li Ou, Michael J Przybilla, Brenda Koniar, Chester B Whitley
Mucopolysaccharidosis type I (MPS I) is a lysosomal disease resulting from deficiency in the α-L-iduronidase (IDUA) hydrolase and subsequent accumulation of glycosaminoglycan (GAG). Clinically, enzyme replacement therapy (ERT) with IDUA achieves negligible neurological benefits presumably due to blood-brain-barrier (BBB) limitations. To investigate the plant lectin ricin B chain (RTB) as a novel carrier for enzyme delivery to the brain, an IDUA:RTB fusion protein (IDUAL), produced in N. benthamiana leaves, was tested in a murine model of Hurler syndrome (MPS I)...
November 28, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29197755/occurrence-removal-and-risk-of-organic-micropollutants-in-wastewater-treatment-plants-across-china-comparison-of-wastewater-treatment-processes
#17
Weiwei Ben, Bing Zhu, Xiangjuan Yuan, Yu Zhang, Min Yang, Zhimin Qiang
This study investigated the occurrence, removal and risk of 42 organic micropollutants (MPs), including 30 pharmaceuticals and personal care products and 12 endocrine disrupting chemicals, in 14 municipal wastewater treatment plants (WWTPs) distributed across China. The composition profiles of different MP categories in the influent, effluent, and excess sludge were explored and the aqueous removal efficiencies of MPs were determined. Quantitative meta-analysis was performed to compare the efficacies of different wastewater treatment processes in eliminating MPs...
November 30, 2017: Water Research
https://www.readbyqxmd.com/read/29197574/endothelial-microparticles-mediated-transfer-of-microrna-19b-promotes-atherosclerosis-via-activating-perivascular-adipose-tissue-inflammation-in-apoe-mice
#18
Changlong Li, Sufang Li, Feng Zhang, Manyan Wu, Huizhu Liang, Junxian Song, Chongyou Lee, Hong Chen
Microparticles(MPs) are the major carriers of circulating microRNAs. Our previous study has shown that microRNA (miR)-19b in endothelial cell-derived microparticles (EMPs) is significantly increased in patients with unstable angina. However, little is known about the relationship between miR-19b in EMPs and the progression of atherosclerosis. The aim of the present study was to define the role and potential mechanism of miR-19b incorporated in EMPs in the development of atherosclerosis. Western-diet-fed apoE-/- mice were injected with phosphate buffered solution(PBS), EMP carrying microRNA control(EMPcontrol) or miR-19b mimic (EMPmiR19b) intravenously...
November 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29194406/whole-body-and-cns-biodistribution-of-rhhns-in-cynomolgus-monkeys-after-intrathecal-lumbar-administration-treatment-implications-for-patients-with-mps-iiia
#19
Jou-Ku Chung, Luying Pan, Kathleen Palmieri, Amir S Youssef, Thomas G McCauley
Mucopolysaccharidosis III type A (MPS IIIA; Sanfilippo syndrome), a genetic lysosomal disorder causing a deficiency of heparan N-sulfatase (HNS), leads to progressive cognitive decline from an early age. An effective enzyme replacement therapy (ERT) for MPS IIIA requires central nervous system (CNS) biodistribution. Recombinant human heparan N-sulfatase (rhHNS), an investigatory ERT for MPS IIIA, has been formulated for intrathecal (IT) administration since intravenous (IV) administration cannot cross the blood brain barrier (BBB) in sufficient amounts to have a therapeutic effect...
December 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29180664/circulating-microparticles-in-acute-diabetic-charcot-foot-exhibit-a-high-content-of-inflammatory-cytokines-and-support-monocyte-to-osteoclast-cell-induction
#20
Jennifer Pasquier, Binitha Thomas, Jessica Hoarau-Véchot, Tala Odeh, Amal Robay, Omar Chidiac, Soha R Dargham, Rebal Turjoman, Anna Halama, Khalid Fakhro, Robert Menzies, Amin Jayyousi, Mahmoud Zirie, Jassim Al Suwaidi, Arash Rafii, Rayaz A Malik, Talal Talal, Charbel Abi Khalil
Circulating microparticles (MPs) are major mediators in cardiovascular complications of type 2 diabetes (T2D); however, their contribution to Charcot foot (CF) disease is not known. Here, we purified and assessed the origin, concentration and content of circulating MPs from 33 individuals: 11 with T2D and acute CF, 11 T2D patients with equivalent neuropathy and 11 non-diabetic controls. First, we demonstrated that there were no differences in the distribution of MPs of endothelial, platelet origin among the 3 groups...
November 27, 2017: Scientific Reports
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