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https://www.readbyqxmd.com/read/28807404/prognostic-usefulness-of-cardiac-stress-test-modalities-in-patients-with-type-2-diabetes-mellitus-who-underwent-myocardial-perfusion-scintigraphy-from-the-basel-asymptomatic-high-risk-diabetics-outcome-trial
#1
Federico Caobelli, Philip Haaf, Joannis Chronis, Gianluca Haenny, Miriam Brinkert, Matthias E Pfisterer, Michael J Zellweger
Our study aimed to assess predictors of the stress test technique used and to evaluate the impact of exercise level achieved on risk stratification in patients with asymptomatic type 2 diabetes without a previous coronary artery disease. Little is known whether co-morbidities of these patients predict the stress technique and whether physical performance provides risk stratification: 400 patients underwent clinical evaluation and myocardial perfusion scintigraphy (MPS) using physical or pharmacological stress...
July 20, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28802989/do-polyethylene-microplastic-beads-alter-the-intestinal-uptake-of-ag-in-rainbow-trout-oncorhynchus-mykiss-analysis-of-the-mp-vector-effect-using-in%C3%A2-vitro-gut-sacs
#2
Farhan R Khan, David Boyle, Elisabeth Chang, Nicolas R Bury
Microplastic (MP) vector effects have been well described in the literature but surprisingly little is in known about the impact of MPs on the intestinal uptake of contaminants. The present study aimed to determine whether the intestinal fate of Ag was affected by the presence of polyethylene MP beads. Ag (added as (110m)Ag) was introduced into the lumen of rainbow trout (Oncorhynchus mykiss) anterior/mid-intestine gut sac preparations as Ag only, Ag and MPs (co-exposure) and Ag-incubated MPs (where Ag was adsorbed to the MP)...
August 9, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28761667/correlation-between-capillary-oxygen-saturation-and-small-intestinal-wall-thickness-in-the-equine-colic-patient
#3
Elisabeth Mirle, Anna Wogatzki, Robert Kunzmann, Axel M Schoenfelder, Lutz F Litzke
The surgical evaluation of haemorrhagic infarcted intestine and the decision for or against bowel resection require a lot of experience and are subjective. The aim of this prospective, clinical study was to examine the correlation between oxygen saturation and small intestinal wall (IW) thickness, using two objective methods. In 22 colicky horses, the blood flow, oxygen saturation and relative amount of haemoglobin were measured intraoperatively via laser Doppler and white light spectroscopy (O2C, oxygen to see, LEA Medizintechnik) at six measuring points (MPs) in small and large intestines...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/28761530/contribution-of-the-xenograft-bone-plate-screw-system-in-lumbar-transpedicular-stabilization-an-in-vivo-study-in-dogs
#4
Sani Sarigul, Hakan Salci, Huseyin Lekesiz, Seref Dogan, Resat Ozcan, Osman Sacit Gorgul, Kaya Aksoy
OBJECTIVES: Xenograft bone plate-screws (XBPSs) can be alternative tools in lumbar transpedicular stabilization (TS). The aim of this study was to show biomechanical and histopathological contribution of the XBPSs system in lumbar TS. MATERIALS AND METHODS: Fifteen (n = 15) hybrid dog and ten (n = 10) L2-4 cadaveric specimens were included in the study. The dogs were separated according to surgical techniques: L3 laminectomy and bilateral facetectomy (LBF) in Group I (experimental group [EG I] (n = 5), L3 LBF plus TS with metal plate-screws (MPSs) in Group II (EG II) (n = 5), and L3 LBF plus TS with XBPSs in Group III (EG III) (n = 5)...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28742317/disposable-microfluidic-immunoarray-device-for-sensitive-breast-cancer-biomarker-detection
#5
Ricardo A G de Oliveira, Elsa María Materón, Matias Eliseo Melendez, Andre L Carvalho, Ronaldo C Faria
Breast cancer is the most common cancer in women worldwide. The detection of biomarkers has played a significant role in the early diagnosis and prognosis of breast cancer. Herein, we describe the construction of a disposable microfluidic immunoarray device (DµID) for rapid and low-cost detection of CA15-3 a protein biomarker for breast cancer. The DµID was constructed using a simple and rapid prototyping technique and was applied to detect CA15-3 in cancer patients. The DµID construction was based on a use of double-sided adhesive card with the microfluidic channel and a screen-printed array with 8 electrodes...
July 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28729395/relationship-between-exercise-volume-and-muscle-protein-synthesis-in-a-rat-model-of-resistance-exercise
#6
Riki Ogasawara, Yuki Arihara, Junya Takegaki, Koichi Nakazato, Naokata Ishii
Resistance exercise (RE) volume is recognized as an important factor that stimulates muscle protein synthesis (MPS) and is considered, at least in part, to be involved in the mammalian target of rapamycin complex 1 (mTORC1)-associated signaling. However, the effects of relatively high doses of muscle contractions on mTORC1 and MPS remain unclear. In the present study, we used an animal model of RE to investigate the relationship between RE volume and MPS. Male Sprague-Dawley rats were subjected to RE, and muscle samples were obtained 6 h after performing 1, 3, 5, 10, or 20 sets of RE...
July 20, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28726114/sex-related-differences-in-serum-matrix-metalloproteinase-9-screening-non-calcified-and-mixed-coronary-atherosclerotic-plaques-in-outpatients-with-chest-pain
#7
Chun Gu, Fang Wang, Zhihui Hou, Bin Lv, Yang Wang, Xiangfeng Cong, Xi Chen
The objective of this study is to evaluate the clinical feasibility of serum matrix metalloproteinase-9 (MMP-9) for screening plaque composition as assessed by coronary computed tomography angiography (CCTA) in outpatients with chest pain,and the effects of sex on this feasibility. Eight hundred and sixty-two consecutive outpatients with chest pain were divided into three groups according to the results of CCTA: non-plaque (NP, n = 474), calcified plaques (CPs, n = 179), non-calcified and mixed plaques (NCPs and MPs, n = 209)...
July 19, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28717974/improvement-of-oral-bioavailability-of-lopinavir-without-co-administration-of-ritonavir-using-microspheres-of-thiolated-xyloglucan
#8
Ashwini R Madgulkar, Mangesh R Bhalekar, Ashwini A Kadam
Lopinavir is a BCS Class IV drug exhibiting poor bioavailability due to P-gp efflux and limited permeation. The aim of this research was to formulate and characterize microspheres of lopinavir using thiolated xyloglucan (TH-MPs) as carrier to improve its oral bioavailability without co-administration of ritonavir. Thiomeric microspheres were prepared by ionotropic gelation between alginic acid and calcium ions. Interaction studies were performed using Fourier transform infrared spectroscopy (FT-IR). The thiomeric microspheres were characterized for its entrapment efficiency, T80, surface morphology, and mucoadhesion employing in vitro wash off test...
July 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28716439/renal-cell-carcinoma-unclassified-with-medullary-phenotype-poorly-differentiated-adenocarcinomas-overlapping-with-renal-medullary-carcinoma
#9
Deepika Sirohi, Steven C Smith, Chisato Ohe, Piergiuseppe Colombo, Mukul Divatia, Ema Dragoescu, Priya Rao, Michelle S Hirsch, Ying-Bei Chen, Rohit Mehra, Mahul B Amin
Renal medullary carcinoma (RMC) is a highly aggressive renal cell carcinoma, arising in the collecting system, and requiring careful correlation with status of sickle cell trait. A panel of international experts has recently proposed provisional diagnostic terminology, renal cell carcinoma, unclassified, with medullary phenotype (RCCU-MP), based on encountering an extraordinarily rare tumor with RMC morphology and immunophenotype in an individual proven not to have a hemoglobinopathy. Herein, we extend this observation to a cohort of five such tumors, morphologically similar to RMC, lacking SMARCB1 expression by immunohistochemistry, but each without evidence of a hemoglobinopathy...
July 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28688943/antioxidative-anti-inflammation-and-lung-protective-effects-of-mycelia-selenium-polysaccharides-from-oudemansiella-radicata
#10
Zheng Gao, Juan Li, Xinling Song, Jianjun Zhang, Xiuxiu Wang, Huijuan Jing, Zhenzhen Ren, Shangshang Li, Chen Zhang, Le Jia
The present work was designed to investigated the antioxidant, anti-inflammation, and pulmonary protective effects of SMPS and MPS from Oudemansiella radicata on LPS-induced lung injured mice. The results demonstrated that SMPS showed potential effects on relieving lung injury and preventing oxidative stress, reflecting by decreasing the serum levels of C3, CRP and GGT, increasing the pulmonary activities of SOD, GSH-Px, CAT and T-AOC, as well as down-regulating the MDA and LPO contents, respectively. Furthermore, the levels of TNF-α (224...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28688844/performance-of-granular-activated-carbon-to-remove-micropollutants-from-municipal-wastewater-a-meta-analysis-of-pilot-and-large-scale-studies
#11
REVIEW
Frank Benstoem, Andreas Nahrstedt, Marc Boehler, Gregor Knopp, David Montag, Hansruedi Siegrist, Johannes Pinnekamp
For reducing organic micropollutants (MP) in municipal wastewater effluents, granular activated carbon (GAC) has been tested in various studies. We did systematic literature research and found 44 studies dealing with the adsorption of MPs (carbamazepine, diclofenac, sulfamethoxazole) from municipal wastewater on GAC in pilot- and large-scale plants. Within our meta-analysis we plot the bed volumes (BV [m(3)water/m(3)GAC]) until the breakthrough criterion of MP-BV20% was reached, dependent on potential relevant parameters (empty bed contact time EBCT, influent DOC DOC0 and manufacturing method)...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28686942/solutions-to-microplastic-pollution-removal-of-microplastics-from-wastewater-effluent-with-advanced-wastewater-treatment-technologies
#12
Julia Talvitie, Anna Mikola, Arto Koistinen, Outi Setälä
Conventional wastewater treatment with primary and secondary treatment processes efficiently remove microplastics (MPs) from the wastewater. Despite the efficient removal, final effluents can act as entrance route of MPs, given the large volumes constantly discharged into the aquatic environments. This study investigated the removal of MPs from effluent in four different municipal wastewater treatment plants utilizing different advanced final-stage treatment technologies. The study included membrane bioreactor treating primary effluent and different tertiary treatment technologies (discfilter, rapid sand filtration and dissolved air flotation) treating secondary effluent...
July 2, 2017: Water Research
https://www.readbyqxmd.com/read/28686664/somatosensory-function-in-patients-with-secondary-adrenal-insufficiency-treated-with-two-different-doses-of-hydrocortisone-results-from-a-randomized-controlled-trial
#13
Jorien Werumeus Buning, Karl-Heinz Konopka, Pauline Brummelman, Janneke Koerts, Robin P F Dullaart, Gerrit van den Berg, Melanie M van der Klauw, Oliver Tucha, Bruce H R Wolffenbuttel, André P van Beek
BACKGROUND: Low cortisol levels are associated with several functional pain syndromes. In patients with secondary adrenal insufficiency (SAI), the lack in endogenous cortisol production is substituted by the administration of oral hydrocortisone (HC). Our previous study showed that a lower dose of HC led to an increase in reported subjective pain symptoms. Whether different doses of HC substitution alter somatosensory functioning in SAI patients has not been established yet. METHODS: In this randomized double blind cross-over trial, forty-six patients with SAI participated...
2017: PloS One
https://www.readbyqxmd.com/read/28681632/graft-product-for-autologous-peripheral-blood-stem-cell-transplantation-enhances-thrombin-generation-and-expresses-procoagulant-microparticles-and-tissue-factor
#14
Fatoumata Sidibe, Anastasia Spanoudaki, Valerie Vanneaux, Elisabeth Mbemba, Jerome Larghero, Patrick Van Dreden, Jean-Pierre Lotz, Ismail Elalamy, Annette K Larsen, Grigoris T Gerotziafas
The beneficial effect of autologous peripheral blood stem cell transplantation (APBSCT) may be compromised by acute vascular complications related to hypercoagulability. We studied the impact of graft product on thrombin generation of normal plasma and the expression of tissue factor (TF) and procoagulant platelet-derived procoagulant microparticles (Pd-MPs) in samples of graft products. Graft products from 10 patients eligible for APBSCT were mixed with platelet-poor plasma (PPP) or platelet-rich plasma (PRP) from healthy volunteers and assessed for in vitro thrombin generation...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28664482/prognostic-value-of-a-faster-low-radiation-myocardial-perfusion-spect-protocol-in-a-czt-camera
#15
Ronaldo S L Lima, Thaís R Peclat, Ana Carolina A H Souza, Aline M K Nakamoto, Felipe M Neves, Victor F Souza, Letícia B Glerian, Andrea De Lorenzo
To determine the prognostic value of a new, ultrafast, low dose myocardial perfusion SPECT (MPS) protocol in a cadmium-zinc telluride (CZT) camera. CZT cameras have introduced significant progress in MPS imaging, offering high-quality images despite lower doses and scan time. Yet, it is unknown if, with such protocol changes, the prognostic value of MPS is preserved. Patients had a 1-day 99 m-Tc-sestamibi protocol, starting with the rest (185-222 MBq) followed by stress (666-740 MBq). Acquisition times were 6 and 3 min, respectively...
June 29, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28642676/international-society-of-sports-nutrition-position-stand-protein-and-exercise
#16
REVIEW
Ralf Jäger, Chad M Kerksick, Bill I Campbell, Paul J Cribb, Shawn D Wells, Tim M Skwiat, Martin Purpura, Tim N Ziegenfuss, Arny A Ferrando, Shawn M Arent, Abbie E Smith-Ryan, Jeffrey R Stout, Paul J Arciero, Michael J Ormsbee, Lem W Taylor, Colin D Wilborn, Doug S Kalman, Richard B Kreider, Darryn S Willoughby, Jay R Hoffman, Jamie L Krzykowski, Jose Antonio
The International Society of Sports Nutrition (ISSN) provides an objective and critical review related to the intake of protein for healthy, exercising individuals. Based on the current available literature, the position of the Society is as follows:An acute exercise stimulus, particularly resistance exercise, and protein ingestion both stimulate muscle protein synthesis (MPS) and are synergistic when protein consumption occurs before or after resistance exercise.For building muscle mass and for maintaining muscle mass through a positive muscle protein balance, an overall daily protein intake in the range of 1...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28638350/branched-chain-amino-acid-ingestion-stimulates-muscle-myofibrillar-protein-synthesis-following-resistance-exercise-in-humans
#17
Sarah R Jackman, Oliver C Witard, Andrew Philp, Gareth A Wallis, Keith Baar, Kevin D Tipton
The ingestion of intact protein or essential amino acids (EAA) stimulates mechanistic target of rapamycin complex-1 (mTORC1) signaling and muscle protein synthesis (MPS) following resistance exercise. The purpose of this study was to investigate the response of myofibrillar-MPS to ingestion of branched-chain amino acids (BCAAs) only (i.e., without concurrent ingestion of other EAA, intact protein, or other macronutrients) following resistance exercise in humans. Ten young (20.1 ± 1.3 years), resistance-trained men completed two trials, ingesting either 5...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28624423/2-methylpyridine-1-ium-1-sulfonate-from-allium-hirtifolium-an-anti-angiogenic-compound-which-inhibits-growth-of-mcf-7-and-mda-mb-231-cells-through-cell-cycle-arrest-and-apoptosis-induction
#18
Hamid-Reza Mohammadi-Motlagh, Yalda Shokohinia, Mahdi Mojarrab, Hassan Rasouli, Ali Mostafaie
Natural products have well been recognized as sources of drugs in cancer treatment. Some medicinal plants contain the constituents with potent anti-angiogenic and anti-cancer effects, which have offered great hopes of being used as drugs for treating various cancers. The present study aims at identifying the anti-angiogenic effects of 2-Methylpyridine-1-ium-1-sulfonate (MPS) isolated from the ethyl acetate extract (EA) of Persian shallot (Allium hirtifolium). In a concentration-dependent manner, the MPS was able to inhibit endothelial cell migration and angiogenesis in both in vivo and in vitro assays, and also significantly suppressed proliferation of MCF-7 and MDA-MB-231 human breast cancer cell lines...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28620710/investigation-of-some-disinfection-chemicals-and-water-quality-parameters-in-swimming-pools-in-the-city-center-and-districts-of-canakkale-turkey
#19
Tolga Uysal, Selehattin Yilmaz, Muhammet Turkoglu, Murat Sadikoglu
In this study, the variations in concentrations of some disinfection chemicals such as cyanuric acid (CyA), free chlorine (FC), and residual chlorine (RC), which affect human health, were investigated in the water of swimming pools. In addition, quality parameters such as temperature, pH, and total alkalinity (TA) in 44 swimming pools located in the city center and districts of Canakkale, Turkey, were examined in the summer period. While FC and RC amounts were analyzed using tablet tests with N-N-diethyl phenylenediamine (DPD 1) and potassium iodine (DPD 3) using the colorimetric method in the comparator, TA and CyA levels were measured with a photometric method...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28620130/circulating-microparticles-are-prognostic-biomarkers-in-advanced-non-small-cell-lung-cancer-patients
#20
Chin-Chou Wang, Chia-Cheng Tseng, Huang-Chih Chang, Kuo-Tung Huang, Wen-Feng Fang, Yu-Mu Chen, Cheng-Ta Yang, Chang-Chun Hsiao, Meng-Chih Lin, Chi-Kung Ho, Hon-Kan Yip
We investigated whether circulating microparticles (MPs) could serve as prognostic biomarkers in non-small cell lung cancer (NSCLC) patients. We enrolled 25 control subjects and 136 NSCLC patients categorized into disease-progression (DP, n=42) and disease-control (DC, n=94) groups. Flow cytometric analysis showed that levels of four types of circulating microparticles (EDAc-MPs, EDAp-MPs, PDAc-MPs and PDAp-MPs) were higher in the study patients than the control subjects (P < 0.04). DP patients showed poor initially performance status and more non-adenocarcinomas than DC patients...
June 6, 2017: Oncotarget
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