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Glucocorticoid AND microbiota

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https://www.readbyqxmd.com/read/29196049/chronic-glucocorticoid-treatment-induced-circadian-clock-disorder-leads-to-lipid-metabolism-and-gut-microbiota-alterations-in-rats
#1
Tao Wu, Luna Yang, Jianguo Jiang, Yinhua Ni, Jiawei Zhu, Xiaojun Zheng, Qi Wang, Xin Lu, Zhengwei Fu
AIM: Glucocorticoids (GCs), steroid hormones synthetized by the adrenal gland, are regulated by circadian cycles, and dysregulation of GC signaling can lead to the development of metabolic syndrome. The effects and potential mechanism of GCs in physiology were investigated in the present study. MAIN METHODS: Male Wistar rats were orally administered dexamethasone sodium phosphate (DEX, 0.01 and 0.05mg/kg body weight per day) for 7weeks. KEY FINDING: DEX treatment attenuated body weight gain and reduced food intake, whereas it induced the accumulation of fat...
November 28, 2017: Life Sciences
https://www.readbyqxmd.com/read/28943841/microglia-an-interface-between-the-loss-of-neuroplasticity-and-depression
#2
REVIEW
Gaurav Singhal, Bernhard T Baune
Depression has been widely accepted as a major psychiatric disease affecting nearly 350 million people worldwide. Research focus is now shifting from studying the extrinsic and social factors of depression to the underlying molecular causes. Microglial activity is shown to be associated with pathological conditions, such as psychological stress, pathological aging, and chronic infections. These are primary immune effector cells in the CNS and regulate the extensive dialogue between the nervous and the immune systems in response to different immunological, physiological, and psychological stressors...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28901864/prenatal-stress-enhances-susceptibility-to-allergic-diseases-of-offspring
#3
Maria Moustaki, Sophia Tsabouri, Kostas Priftis, Konstantinos Douros
BACKGROUND AND OBJECTIVES: Maternal prenatal stress (MPS) may result in a range of long-term consequences in the offspring among which is susceptibility to allergic diseases. This review presents the current knowledge on the pathways through which MPS may affect the fetus, and the existing evidence regarding the association between MPS and development of allergy in the offspring. RESULT AND DISCUSSION: A pivotal mediator triggered in response to stress is the release of glucocorticoids (GC)...
September 12, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28878025/gallbladder-derived-surfactant-protein-d-regulates-gut-commensal-bacteria-for-maintaining-intestinal-homeostasis
#4
Hana Sarashina-Kida, Hideo Negishi, Junko Nishio, Wataru Suda, Yuki Nakajima, Mika Yasui-Kato, Keiko Iwaisako, Sujin Kang, Nobuyasu Endo, Hideyuki Yanai, Masataka Asagiri, Hiroshi Kida, Masahira Hattori, Atsushi Kumanogoh, Tadatsugu Taniguchi
The commensal microbiota within the gastrointestinal tract is essential in maintaining homeostasis. Indeed, dysregulation in the repertoire of microbiota can result in the development of intestinal immune-inflammatory diseases. Further, this immune regulation by gut microbiota is important systemically, impacting health and disease of organ systems beyond the local environment of the gut. What has not been explored is how distant organs might in turn shape the microbiota via microbe-targeted molecules. Here, we provide evidence that surfactant protein D (SP-D) synthesized in the gallbladder and delivered into intestinal lumen binds selectively to species of gut commensal bacteria...
September 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28816544/animal-inflammation-based-models-of-depression-and-their-application-to-drug-discovery
#5
REVIEW
Li Ma, Konstantin A Demin, Tatyana O Kolesnikova, Sergey L Kharsko, Xiaokang Zhu, Xiaodong Yuan, Cai Song, Darya A Meshalkina, Brian E Leonard, Li Tian, Allan V Kalueff
Depression, anxiety and other affective disorders are globally widespread and severely debilitating human brain diseases. Despite their high prevalence and mental health impact, affective pathogenesis is poorly understood, and often remains recurrent and resistant to treatment. The lack of efficient antidepressants and presently limited conceptual innovation necessitate novel approaches and new drug targets in the field of antidepressant therapy. Areas covered: Herein, the authors discuss the emerging role of neuro-immune interactions in affective pathogenesis, which can become useful targets for CNS drug discovery, including modulating neuroinflammatory pathways to alleviate affective pathogenesis...
October 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28624548/glucocorticoids-and-gut-bacteria-the-galf-hypothesis-in-the-metagenomic-era
#6
REVIEW
David J Morris, Jason M Ridlon
A new concept is emerging in biomedical sciences: the gut microbiota is a virtual 'organ' with endocrine function. Here, we explore the literature pertaining to the role of gut microbial metabolism of endogenous adrenocorticosteroids as a contributing factor in the etiology of essential hypertension. A body of literature demonstrates that bacterial products of glucocorticoid metabolism are absorbed into the portal circulation, and pass through the kidney before excretion into urine. Apparent mineralocorticoid excess (AME) syndrome patients were found to have congenital mutations resulting in non-functional renal 11β-hydroxysteroid dehydrogenase-2 (11β-HSD2) and severe hypertension often lethal in childhood...
June 15, 2017: Steroids
https://www.readbyqxmd.com/read/28512033/bifidobacterium-cect-7765-modulates-early-stress-induced-immune-neuroendocrine-and-behavioral-alterations-in-mice
#7
A Moya-Pérez, A Perez-Villalba, A Benítez-Páez, I Campillo, Y Sanz
Emerging evidence suggests that there is a window of opportunity within the early developmental period, when microbiota-based interventions could play a major role in modulating the gut-brain axis and, thereby, in preventing mood disorders. This study aims at evaluating the effects and mode of action of Bifidobacterium pseudocatenulatum CECT 7765 in a murine model of chronic stress induced by maternal separation (MS). C57Bl/6J male breast-fed pups were divided into four groups, which were subjected or not to MS and supplemented with placebo or B...
May 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28342428/revealing-the-influence-of-glucocorticoid-treatment-on-the-excretion-of-anabolic-androgenic-steroids-in-horses-through-in-vitro-digestive-simulations-and-an-in-vivo-case-study
#8
Anneleen Decloedt, Sander Damen, Lynn Vanhaecke
Anabolic-androgenic steroids (AAS) are strictly forbidden in equine sports because of their stimulating effect on muscle growth and performance. Nevertheless, low levels of AAS have been found in some horses, untreated with AAS. Glucocorticoids (GC), used as an anti-inflammatory therapy and structurally related to AAS, might play a role in this phenomenon. In order to unravel this possible correlation the influence of glucocorticoid treatment on the excretion of AAS was studied both in vivo and in vitro. In vivo effects were investigated by analysing urine samples collected from a gelding treated with betamethasone...
February 24, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28314858/identification-and-characterization-of-a-20%C3%AE-hsdh-from-the-anaerobic-gut-bacterium-butyricicoccus-desmolans-atcc-43058
#9
Saravanan Devendran, Celia Méndez-García, Jason M Ridlon
Members of the gastrointestinal microbiota are known to convert glucocorticoids to androstanes, which are subsequently converted to potent androgens by other members of the gut microbiota or host tissues. Butyricicoccus desmolans and Clostridium cadaveris have previously been reported for steroid-17,20-desmolase and 20β-hydroxysteroid dehydrogenase (HSDH) activities that are responsible for androstane formation from cortisol; however, the genes encoding these enzymes have yet to be reported. In this work, we identified and located a gene encoding 20β-HSDH in both B...
May 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28237726/transfer-of-maternal-psychosocial-stress-to-the-fetus
#10
REVIEW
Florian Rakers, Sven Rupprecht, Michelle Dreiling, Christoph Bergmeier, Otto W Witte, Matthias Schwab
Psychosocial maternal stress experienced during different vulnerable periods throughout gestation is thought to increase the individual's risk to develop neuropsychiatric, cardiovascular and metabolic disease in later life. Cortisol has generally been identified as the major mediator of maternal stress transfer to the fetus. Its lipophilic nature allows a trans-placental passage and thus excessive maternal cortisol could persistently impair the development of the fetal hypothalamic-pituitary-adrenal axis (HPAA)...
February 22, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28053782/dexamethasone-abrogates-the-antimicrobial-and-antibiofilm-activities-of-different-drugs-against-clinical-isolates-of-staphylococcus-aureus-and-pseudomonas-aeruginosa
#11
Aquila Rodrigues, André Gomes, Pedro Henrique Ferreira Marçal, Marcus Vinícius Dias-Souza
Staphylococcus aureus and Pseudomonas aeruginosa are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding sequelae. Although different pharmaceutical dosage forms of antimicrobials combined to corticosteroids are available, studies on the interference of corticosteroids on the pharmacological activity of antimicrobials are scarce and controversial...
January 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/27957334/parasites-stress-and-reindeer-infection-with-abomasal-nematodes-is-not-associated-with-elevated-glucocorticoid-levels-in-hair-or-faeces
#12
A M Carlsson, G Mastromonaco, E Vandervalk, S Kutz
Stress hormones (glucocorticoids), incorporated into hair/fur and faeces, have been proposed as biomarkers of overall health in wildlife. Although such biomarkers may be helpful for wildlife conservation and management, their use has rarely been validated. There is a paucity of studies examining the variation of stress hormones in mammals and how they relate to other health measures, such as parasitism. Parasites are ubiquitous in wildlife and can influence the fitness of individual animals and populations...
2016: Conservation Physiology
https://www.readbyqxmd.com/read/27865823/gut-hormones-and-gut-microbiota-implications-for-kidney-function-and-hypertension
#13
REVIEW
Baris Afsar, Nosratola D Vaziri, Gamze Aslan, Kayhan Tarim, Mehmet Kanbay
Increased blood pressure (BP) and chronic kidney disease are two leading risk factors for cardiovascular disease. Increased sodium intake is one of the most important risk factors for development of hypertension. Recent data have shown that gut influences kidney function and BP by variety of mechanisms. Various hormones and peptides secreted from gut such as gastrin, glucocorticoids, Glucagon-like peptide-1 impact on kidney function and BP especially influencing sodium absorption from gut. These findings stimulate scientist to find new therapeutic options such as tenapanor for treatment of hypertension by blocking sodium absorption from gut...
December 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27810280/-1-h-nmr-based-metabonomic-study-on-the-effects-of-epimedium-on-glucocorticoid-induced-osteoporosis
#14
Sina Pan, Ali Chen, Zhihui Han, Yaling Wang, Xin Lu, Yongxia Yang
Glucocorticoids are widely used in clinical practice for the treatment of many immune-mediated and inflammatory diseases, and glucocorticoid-induced osteoporosis (GIO) is the most common type of secondary osteoporosis. Epimedium is one of the most commonly used traditional Chinese medicines for treating osteoporosis. In the present study, we systematically analysed the metabonomic characteristics of GIO model rats and elucidated the therapeutic effect of Epimedium by using a (1)H NMR-based metabonomic approach in conjunction with multivariate data analysis...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27742460/behavioural-and-neurochemical-consequences-of-chronic-gut-microbiota-depletion-during-adulthood-in-the-rat
#15
A E Hoban, R D Moloney, A V Golubeva, K A McVey Neufeld, O O'Sullivan, E Patterson, C Stanton, T G Dinan, G Clarke, J F Cryan
Gut microbiota colonization is a key event for host physiology that occurs early in life. Disruption of this process leads to altered brain development which ultimately manifests as changes in brain function and behaviour in adulthood. Studies using germ-free (GF) mice highlight the extreme impact on brain health that results from life without commensal microbes. However, the impact of microbiota disturbances occurring in adulthood is less studied. To this end, we depleted the gut microbiota of 10-week-old male SpragueDawley rats via chronic antibiotic treatment...
December 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27431777/the-glucocorticoid-budesonide-has-protective-and-deleterious-effects-in-experimental-colitis-in-mice
#16
COMPARATIVE STUDY
Borja Ocón, Carlos J Aranda, Reyes Gámez-Belmonte, María Dolores Suárez, Antonio Zarzuelo, Olga Martínez-Augustin, Fermín Sánchez de Medina
Glucocorticoids are widely used for the management of inflammatory bowel disease, albeit with known limitations for long-term use and relevant adverse effects. In turn, they have harmful effects in experimental colitis. We aimed to explore the mechanism and possible implications of this phenomenon. Regular and microbiota depleted C57BL/6 mice were exposed to dextran sulfate sodium (DSS) to induce colitis and treated with budesonide. Colonic inflammation and animal status were compared. In vitro epithelial models of wound healing were used to confirm the effects of glucocorticoids...
September 15, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27280726/coexpression-network-analysis-of-benign-and-malignant-phenotypes-of-siv-infected-sooty-mangabey-and-rhesus-macaque
#17
COMPARATIVE STUDY
Zhao-Wan Yang, Yan-Hua Jiang, Chuang Ma, Guido Silvestri, Steven E Bosinger, Bai-Lian Li, Ambrose Jong, Yan-Hong Zhou, Sheng-He Huang
To explore the differences between the extreme SIV infection phenotypes, nonprogression (BEN: benign) to AIDS in sooty mangabeys (SMs) and progression to AIDS (MAL: malignant) in rhesus macaques (RMs), we performed an integrated dual positive-negative connectivity (DPNC) analysis of gene coexpression networks (GCN) based on publicly available big data sets in the GEO database of NCBI. The microarray-based gene expression data sets were generated, respectively, from the peripheral blood of SMs and RMs at several time points of SIV infection...
2016: PloS One
https://www.readbyqxmd.com/read/27075753/psychological-stress-exacerbates-nsaid-induced-small-bowel-injury-by-inducing-changes-in-intestinal-microbiota-and-permeability-via-glucocorticoid-receptor-signaling
#18
Kenichi Yoshikawa, Chie Kurihara, Hirotaka Furuhashi, Takeshi Takajo, Koji Maruta, Yuichi Yasutake, Hirokazu Sato, Kazuyuki Narimatsu, Yoshikiyo Okada, Masaaki Higashiyama, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Hisao Tajiri, Ryota Hokari
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are popular painkillers, but they have serious side effects, not only in the upper gastrointestinal tract but also in the small intestine. It is well known that psychological stress may exacerbate various gastrointestinal diseases. The aim of this study was to determine whether psychological stress exacerbates NSAID enteropathy and to determine the possible underlying mechanisms for this. METHODS: Experiment 1: mice were exposed to water avoidance stress (WAS) or sham stress for 1 h per day for 8 consecutive days, and then enteropathy was induced by indomethacin...
January 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/26909656/epigenome-microbiome-crosstalk-a-potential-new-paradigm-influencing-neonatal-susceptibility-to-disease
#19
Rene Cortese, Lei Lu, Yueyue Yu, Douglas Ruden, Erika C Claud
Preterm birth is the leading cause of infant morbidity and mortality. Necrotizing enterocolitis (NEC) is an inflammatory bowel disease affecting primarily premature infants, which can be lethal. Microbial intestinal colonization may alter epigenetic signatures of the immature gut establishing inflammatory and barrier properties predisposing to the development of NEC. We hypothesize that a crosstalk exists between the epigenome of the host and the initial intestinal colonizing microbiota at critical neonatal stages...
March 3, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/26588440/identification-of-key-active-constituents-of-buchang-naoxintong-capsules-with-therapeutic-effects-against-ischemic-stroke-by-using-an-integrative-pharmacology-based-approach
#20
Xu Haiyu, Shi Yang, Zhang Yanqiong, Jia Qiang, Li Defeng, Zhang Yi, Liu Feng, Yang Hongjun
Integrative pharmacology has been used to identify the key active constituents (KACs) of Buchang Naoxintong capsules (BNCs), a traditional Chinese medical preparation; this approach involves the evaluation of the content profiles and drug-like properties of the BNC constituents and development of an ingredient-target network. In this study, we used a sensitive analytical method to simultaneously identify and quantify 16 constituents of BNCs. Metabolism of these constituents by gut microbiota and human oral bioavailability were predicted using an in silico approach, followed by construction of networks to analyze the interactions between BNC constituents, their molecular targets, and proteins known to be the molecular targets for Food and Drug Administration-approved colitis medication...
January 2016: Molecular BioSystems
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