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https://www.readbyqxmd.com/read/29896759/correlates-of-depressive-symptoms-among-older-adults-living-with-hiv
#1
José Alberto Avila-Funes, Alfonso Zamudio-Rodríguez, Luis Arnoldo Muñoz-Nevárez, Pablo Francisco Belaunzarán-Zamudio, Julio Alberto Díaz-Ramos, Juan Luis Alcala-Zermeno, Camille Ouvrard, Juan Sierra-Madero, Hélène Amieva
OBJECTIVE: To establish the correlates of depressive symptoms among Mexican community-dwelling older people living with HIV (PLWHIV). METHODS: Cross-sectional, 2-center study of 328 participants aged 50 or older being followed in the outpatient HIV clinics of 2 tertiary care hospitals in Mexico. Data were obtained through a comprehensive geriatric assessment. Multivariate logistic regression analyses were performed to identify the correlates of depressive symptoms...
June 13, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29895271/correction-to-case-series-of-creutzfeldt-jakob-disease-in-a-third-level-hospital-in-quito
#2
Germaine Eleanor Torres Herrán, Andrés Damián Ortega Heredia, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos, Edgar Patricio Correa Díaz
Following publication of the original article [1], Andrés Damián Ortega Heredia requested that his name be corrected from.
June 12, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29880013/role-of-cxcl13-and-ccl20-in-the-recruitment-of-b-cells-to-inflammatory-foci-in-chronic-arthritis
#3
Estefanía Armas-González, María Jesús Domínguez-Luis, Ana Díaz-Martín, Mayte Arce-Franco, Javier Castro-Hernández, Gabriela Danelon, Vanesa Hernández-Hernández, Sagrario Bustabad-Reyes, Alberto Cantabrana, Mariagrazia Uguccioni, Federico Díaz-González
BACKGROUND: B cells exert their pathogenic action in rheumatoid arthritis (RA) locally in the synovium. This study was undertaken to elucidate the chemokines responsible for the recruitment of B cells in the inflamed synovium, taking into account that the rich chemokine milieu present in the synovial tissue can fine-tune modulate discrete chemokine receptors. METHODS: Expression levels of chemokine receptors from the CC and CXC family, as well as CD27, were assessed by flow cytometry in CD20+ mononuclear cells isolated from the peripheral blood (PB) and synovial fluid (SF) of RA and psoriatic arthritis patients...
June 7, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29864507/leishmania-mexicana-gp63-is-the-enzyme-responsible-for-cyclooxygenase-cox-activity-in-this-parasitic-protozoa
#4
Luis Alberto Estrada-Figueroa, José Alfredo Díaz-Gandarilla, Verónica Ivonne Hernández-Ramírez, María Maylen Arrieta-González, Carlos Osorio-Trujillo, José Luis Rosales-Encina, Toledo-Leyva Alfredo, Patricia Talamás-Rohana
Cyclooxygenase-2 (COX-2) is an enzyme responsible of prostaglandins production, such as prostaglandin E2 (PGE2 ), an immune response modulator that regulates the immune system to inhibit Th1 and to promote Th2 cytokines production. Many parasites modulate their host immune response through PGE2 effects; however, in parasites, only one protein with COX activity has been described, the α-actinin of Entamoeba histolytica. Prostanoids production has been reported in some species of Leishmania but not the enzymes responsible of their production...
June 1, 2018: Biochimie
https://www.readbyqxmd.com/read/29705885/round-atelectasis-pet-ct-findings
#5
Luis Gorospe, Raquel Jover-Díaz, Gemma María Muñoz-Molina, Alberto Cabañero-Sánchez, Esther Gambí-Pisonero, Ignacio Barbolla-Díaz
No abstract text is available yet for this article.
April 28, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29703169/case-series-of-creutzfeldt-jakob-disease-in-a-third-level-hospital-in-quito
#6
Germaine Eleanor Torres Herrán, Andrés Damián Ortega Herrera, Braulio Martinez Burbano, Marcos Serrano-Dueñas, María Angélica Ortiz Yepez, Raúl Alberto Barrera Madera, Luis Alfredo Masabanda Campaña, Guillermo David Baño Jiménez, Denny Maritza Santos Saltos, Edgar Patricio Correa Díaz
BACKGROUND: Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder that affects mammals and humans. The prevalence of this disease in the United States is 0.5 to 1 per million inhabitants. So far in Ecuador, we do not know what the prevalence or incidence is, and only one case report has been written. CASE PRESENTATION: We present a case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito. The average age of symptom onset in our patients was 58...
April 27, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29666142/tumor-xenograft-modeling-identifies-an-association-between-tcf4-loss-and-breast-cancer-chemoresistance
#7
Gorka Ruiz de Garibay, Francesca Mateo, Agostina Stradella, Rafael Valdés-Mas, Luis Palomero, Jordi Serra-Musach, Diana A Puente, Ander Díaz-Navarro, Gardenia Vargas-Parra, Eva Tornero, Idoia Morilla, Lourdes Farré, María Martinez-Iniesta, Carmen Herranz, Emmet McCormack, August Vidal, Anna Petit, Teresa Soler, Conxi Lázaro, Xose S Puente, Alberto Villanueva, Miguel Angel Pujana
Understanding the mechanisms of cancer therapeutic resistance is fundamental to improving cancer care. There is clear benefit from chemotherapy in different breast cancer settings; however, knowledge of the mutations and genes that mediate resistance is incomplete. In this study, by modeling chemoresistance in patient-derived xenografts (PDXs), we show that adaptation to therapy is genetically complex and identify that loss of transcription factor 4 (TCF4; also known as ITF2) is associated with this process...
May 18, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29656796/-effect-of-influenza-vaccination-in-primary-healthcare-workers-and-the-general-population-in-gran-canaria-a-cross-sectional-study
#8
María Del Mar Martín-Rodríguez, José Antonio Díaz-Berenguer, José Luis Alonso-Bilbao, Antonio Cabeza-Mora, Francisco Navarro-Vázquez, Alberto Espiñeira-Francés, Lidia Nuez-Herrera
OBJECTIVE: To estimate the effect of the influenza vaccination in Primary Healthcare workers and the general population vaccinated during the 2015/2016 campaign. DESIGN: Cross-sectional study. SETTING: All the Primary Healthcare centres within the Gran Canaria healthcare region. PARTICIPANTS: A total of 1,868 Primary Healthcare workers (33.5% men; 66.5% women) and 795,605 individuals from the general population (49.4% men; 50...
April 12, 2018: Atencion Primaria
https://www.readbyqxmd.com/read/29652870/surveillance-for-the-identification-of-cases-of-acute-respiratory-infection-by-enterovirus-d68-in-children-in-a-tertiary-level-care-hospital-during-2014-2016
#9
Ana Estela Gamiño-Arroyo, José Luis Sánchez-Huerta, Alicia Elhaín de la Garza-López, Israel Parra-Ortega, Noé Escobar-Escamilla, Edgar Mendieta-Condado, Fabiola Garcés-Ayala, Gisela Barrera-Badillo, José Ernesto Ramírez-González, José Alberto Díaz-Quiñonez, Daniela de la Rosa-Zamboni
Background: The reemergence of enterovirus D68 (EV-D68) infections in the United States was reported from August-October 2014 (691 cases). In Mexico, an outbreak at the National Institute of Respiratory Diseases was reported (24 cases). The results of epidemiological surveillance of Enterovirus sp. (EV) and other respiratory viruses in a national pediatric tertiary care level hospital are presented. Methods: Following the alert issued by the reemergence of EV-D68 in 2014, epidemiological surveillance -which only detected respiratory viruses by PCR in patients with influenza-like illness using nasopharyngeal swabs- expanded to include children with asthma exacerbation or acute respiratory distress...
2018: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29629503/characterization-of-bioactive-compounds-of-annona-cherimola-l-leaves-using-a-combined-approach-based-on-hplc-esi-tof-ms-and-nmr
#10
Elixabet Díaz-de-Cerio, Luis Manuel Aguilera-Saez, Ana María Gómez-Caravaca, Vito Verardo, Alberto Fernández-Gutiérrez, Ignacio Fernández, David Arráez-Román
Annona cherimola Mill. (cherimoya) has widely been used as food crop. The leaves of this tree possess several health benefits, which are, in general, attributed mainly to its bioactive composition. However, literature concerning a comprehensive characterization based on a combined approach, which consists of nuclear magnetic resonance (NMR) and high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS), from these leaves is scarce. Thus, the aim of this work was to study the polar profile of full extracts of cherimoya leaves by using these tools...
June 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29559829/nutrients-restriction-upregulates-adiponectin-in-epicardial-or-subcutaneous-adipose-tissue-impact-in-de-novo-heart-failure-patients
#11
Rosa M Agra, Ángel Fernández-Trasancos, Esther Díaz-Rodríguez, Alberto Cordero, Alfonso Varela-Román, Inés Gómez-Otero, J Nicolás López- Canoa, Ángel Luis Fernández, José Manuel Martínez-Cereijo, José Ramón González-Juanatey, Sonia Eiras
Background: Hyperadiponectinemia is an indicator of worse outcomes in advanced heart failure (HF), its role in de novo HF is less clear. Objective: Because this protein is a hormone with starvation properties, we wanted to know its association with nutritional state and its regulator factors in de novo HF. Methods: Adiponectin circulating levels were determined by ELISA at discharge in patients admitted for de novo HF (n=74). Nutritional status was determined by CONUT score. Univariate and multivariate Cox regression analyses were employed to calculate the estimated hazard ratio (HR) with 95% confidence interval (CI) for death or all-cause readmission...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29475763/evaluation-of-the-immunogenic-capability-of-the-bcg-strains-bcg%C3%AE-bcg1419c-and-bcg%C3%AE-bcg1416c-in-a-three-dimensional-human-lung-tissue-model
#12
Venkata Ramanarao Parasa, Jeronimo Rose, Luis Alberto Castillo-Diaz, Michel de Jesús Aceves-Sánchez, Perla Jazmín Vega-Domínguez, Maria Lerm, Mario Alberto Flores-Valdez
Tuberculosis (TB) still remains as an unmet global threat. The current vaccine is not fully effective and novel alternatives are needed. Here, two vaccine candidate strains derived from BCG carrying deletions in the BCG1416c or BCG1419c genes were analysed for their capacity to modulate the cytokine/chemokine profile and granuloma formation in a human lung tissue model (LTM). We show that the clustering of monocytes, reminiscent of early granuloma formation, in LTMs infected with BCG strains was similar for all of them...
March 27, 2018: Vaccine
https://www.readbyqxmd.com/read/29440218/impact-of-renin-angiotensin-system-inhibitors-on-clinical-outcomes-and-ventricular-remodelling-after-transcatheter-aortic-valve-implantation-rationale-and-design-of-the-rastavi-randomised-multicentre-study
#13
Ignacio J Amat-Santos, Pablo Catalá, Felipe Diez Del Hoyo, Jose A Fernandez-Diaz, Juan H Alonso-Briales, María Del Trigo, Ander Regueiro, Pablo Juan-Salvadores, Vicenç Serra, Enrique Gutierrez-Ibanes, Antonio J Muñoz-García, Luis Nombela-Franco, Manel Sabate, Victor A Jimenez-Diaz, Bruno García Del Blanco, Javier López, Luis H Varela-Falcón, Teresa Sevilla, Roman Arnold, Ana Revilla, J Alberto San Roman
INTRODUCTION: Transcatheter aortic valve implantation (TAVI) as a treatment in severe aortic stenosis (AS) is an excellent alternative to conventional surgical replacement. However, long-term outcomes are not benign. Renin-angiotensin system (RAS) blockade has shown benefit in terms of adverse remodelling in severe AS and after surgical replacement. METHODS AND ANALYSIS: The RAS blockade after TAVI (RASTAVI) trial aims to detect if there is a benefit in clinical outcomes and ventricular remodelling with this therapeutic strategy following the TAVI procedure...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29395491/epistasis-analysis-of-metabolic-genes-polymorphisms-associated-with-ischemic-heart-disease-in-yucatan
#14
Igrid García-González, Roger Iván López-Díaz, José Reyes Canché-Pech, Alberto de Jesús Solís-Cárdenas, Jorge A Flores-Ocampo, Renán Mendoza-Alcocer, Luis Fernando Herrera-Sánchez, Marco Antonio Jiménez-Rico, Adrián Alejandro Ceballos-López, María E López-Novelo
OBJECTIVE: Epistasis is a type of genetic interaction that could explain much of the phenotypic variability of complex diseases. In this work, the effect of epistasis of metabolic genes and cardiovascular risk on the susceptibility to the development of ischemic heart disease in Yucatan was determined. METHODS: Case-control study in 79 Yucatecan patients with ischemic heart disease and 101 healthy controls matched by age and origin with cases. The polymorphisms -108CT, Q192R, L55M (paraoxonase 1; PON1), C677T, A1298C (methylenetetrahydrofolate reductase; MTHFR), and the presence/absence of the glutathione S-transferase T1 (GSTT1) gene were genotyped...
January 28, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29296947/detectable-clonal-mosaicism-in-blood-as-a-biomarker-of-cancer-risk-in-fanconi-anemia
#15
Judith Reina-Castillón, Roser Pujol, Marcos López-Sánchez, Benjamín Rodríguez-Santiago, Miriam Aza-Carmona, Juan Ramón González, José Antonio Casado, Juan Antonio Bueren, Julián Sevilla, Isabel Badel, Albert Català, Cristina Beléndez, María Ángeles Dasí, Cristina Díaz de Heredia, Jean Soulier, Detlev Schindler, Luis Alberto Pérez-Jurado, Jordi Surrallés
Detectable clonal mosaicism for large chromosomal events has been associated with aging and an increased risk of hematological and some solid cancers. We hypothesized that genetic cancer predisposition disorders, such as Fanconi anemia (FA), could manifest a high rate of chromosomal mosaic events (CMEs) in peripheral blood, which could be used as early biomarkers of cancer risk. We studied the prevalence of CMEs by single-nucleotide polymorphism (SNP) array in 130 FA patients' blood DNA and their impact on cancer risk...
January 24, 2017: Blood Advances
https://www.readbyqxmd.com/read/29232453/detection-of-zika-virus-in-aedes-mosquitoes-from-mexico
#16
Herón Huerta, Jesús Felipe González-Roldán, Gustavo Sánchez-Tejeda, Fabián Correa-Morales, Francisco Eduardo Romero-Contreras, Raúl Cárdenas-Flores, Mónica Liliana Rangel-Martínez, Juan Manuel Mata-Rivera, José de Jesús Siller-Martínez, Gonzalo M Vazquez-Prokopec, Pablo Manrique-Saide, Felipe Dzul-Manzanilla, Mauricio Vázquez-Pichardo, Claudia Rosales-Jiménez, María de la Luz Torres-Rodríguez, Alma Núñez-León, Belem Torres-Longoria, Irma López-Martínez, Cuitláhuac Ruíz-Matus, Pablo Antonio Kuri-Morales, José Alberto Díaz-Quiñónez
Background: We report on the results of an entomovirological surveillance system of Aedes populations performed by the Ministry of Health of the central state of San Luis Potosí, Mexico. Methods: Indoor adult Aedes aegypti and Aedes albopictus pools collected at San Martín, Tamazunchale, Ciudad Valles, Metlapa, Ebano, Tamuin and Axtla during the dry season of 2016 were examined for the presence of dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses using real-time PCR...
July 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29101063/anti-staphylococcal-properties-of-four-plant-extracts-against-sensitive-and-multi-resistant-bacterial-strains-isolated-from-cattle-and-rabbits
#17
Mayra Fernanda Echeverría Medina, Peter Adeniyi Alaba, María Elena Estrada-Zuñiga, Valente Velázquez-Ordoñez, Alberto Barbabosa-Pliego, Mohmaed Z M Salem, María Uxúa Alonso-Fresán, Luis Miguel Camacho-Díaz, Abdelfattah Z M Salem
The aim of this study is to investigate the biopotency of methanolic extracts of Vitex mollis, Psidium guajava, Dalbergia retusa, and Crescential alata leaves against various staphylococcal strains isolated from cattle and rabbits. Methicillin-resistant S. aureus strains were isolated from cattle, while other strains were isolated from rabbits using standard methodology. The total phytochemical phenolic and saponins contents were obtained being the main groups of the antinutritional factors. The antimicrobial activity of the extracts against the standard culture of S...
December 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29065142/safety-and-vaccine-induced-hiv-1-immune-responses-in-healthy-volunteers-following-a-late-mva-b-boost-4-years-after-the-last-immunization
#18
RANDOMIZED CONTROLLED TRIAL
Alberto C Guardo, Carmen Elena Gómez, Vicens Díaz-Brito, Judit Pich, Joan Albert Arnaiz, Beatriz Perdiguero, Juan García-Arriaza, Nuria González, Carlos O S Sorzano, Laura Jiménez, José Luis Jiménez, María Ángeles Muñoz-Fernández, José M Gatell, José Alcamí, Mariano Esteban, Juan Carlos López Bernaldo de Quirós, Felipe García, Montserrat Plana
BACKGROUND: We have previously shown that an HIV vaccine regimen including three doses of HIV-modified vaccinia virus Ankara vector expressing HIV-1 antigens from clade B (MVA-B) was safe and elicited moderate and durable (1 year) T-cell and antibody responses in 75% and 95% of HIV-negative volunteers (n = 24), respectively (RISVAC02 study). Here, we describe the long-term durability of vaccine-induced responses and the safety and immunogenicity of an additional MVA-B boost. METHODS: 13 volunteers from the RISVAC02 trial were recruited to receive a fourth dose of MVA-B 4 years after the last immunization...
2017: PloS One
https://www.readbyqxmd.com/read/28973441/pol%C3%AE-tumor-variants-decrease-the-efficiency-and-accuracy-of-nhej
#19
Guillermo Sastre-Moreno, John M Pryor, Alberto Díaz-Talavera, José F Ruiz, Dale A Ramsden, Luis Blanco
The non homologous end-joining (NHEJ) pathway of double-strand break (DSB) repair often requires DNA synthesis to fill the gaps generated upon alignment of the broken ends, a complex task performed in human cells by two specialized DNA polymerases, Polλ and Polμ. It is now well established that Polμ is the one adapted to repair DSBs with non-complementary ends, the most challenging scenario, although the structural basis and physiological implications of this adaptation are not fully understood. Here, we demonstrate that two human Polμ point mutations, G174S and R175H, previously identified in two different tumor samples and affecting two adjacent residues, limit the efficiency of accurate NHEJ by Polμ in vitro and in vivo...
September 29, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28935381/-sexist-attitudes-and-recognition-of-abuse-in-young-couples
#20
Vanesa García-Díaz, Alberto Lana-Pérez, Ana Fernández-Feito, Carolina Bringas-Molleda, Luis Rodríguez-Franco, F Javier Rodríguez-Díaz
AIM: To explore the association between gender-role attitudes and the recognition of abuse among adolescents and young adults during dating relationships. DESIGN: Cross-correlation study. LOCATION: 57 schools of secondary education, vocational education and university in five provinces of Spain (Huelva, Seville, A Coruña, Pontevedra and Asturias). PARTICIPANTS: 4,337 students aged between 15 and 26 years (40.6% males and 59...
September 18, 2017: Atencion Primaria
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