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https://www.readbyqxmd.com/read/29054571/associations-of-dc-sign-cd209-promoter-336g-a-polymorphism-rs4804803-with-dengue-infection-a-systematic-review-and-meta-analysis
#1
Noel Pabalan, Suwit Chaisri, Sompong Tabunhan, Achara Phumyen, Hamdi Jarjanazi, Theodore S Steiner
BACKGROUND AND AIM: Dengue virus entry into a host is associated with a cell surface protein, DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin). A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF). However, the reported associations of these two outcomes and CD-209 have been inconsistent, which prompted a meta-analysis to obtain more precise estimates...
October 17, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29048283/unrecognized-dengue-virus-infections-in-children-western-kenya-2014-2015
#2
David M Vu, Noah Mutai, Claire J Heath, John M Vulule, Francis M Mutuku, Bryson A Ndenga, A Desiree LaBeaud
We detected a cluster of dengue virus infections in children in Kenya during July 2014-June 2015. Most cases were serotype 1, but we detected all 4 serotypes, including co-infections with 2 serotypes. Our findings implicate dengue as a cause of febrile illness in this population and highlight a need for robust arbovirus surveillance.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29040262/serological-and-spatial-analysis-of-alphavirus-and-flavivirus-prevalence-and-risk-factors-in-a-rural-community-in-western-kenya
#3
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5-14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression...
October 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29031286/surveillance-of-vector-borne-infections-chikungunya-dengue-and-malaria-in-bo-sierra-leone-2012-2013
#4
Donald F Dariano, Chris R Taitt, Kathryn H Jacobsen, Umaru Bangura, Alfred S Bockarie, Moses J Bockarie, Joseph Lahai, Joseph M Lamin, Tomasz A Leski, Chadwick Yasuda, David A Stenger, Rashid Ansumana
Malaria remains a significant cause of morbidity and mortality in West Africa, but the contribution of other vector-borne infections (VBIs) to the burden of disease has been understudied. We used rapid diagnostic tests (RDTs) for three VBIs to test blood samples from 1,795 febrile residents of Bo City, Sierra Leone, over a 1-year period in 2012-2013. In total, 24% of the tests were positive for malaria, fewer than 5% were positive for markers of dengue virus infection, and 39% were positive for IgM directed against chikungunya virus (CHIKV) or a related alphavirus...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29029938/dengvaxia-sensitizes-seronegatives-to-vaccine-enhanced-disease-regardless-of-age
#5
Scott B Halstead
During a large scale clinical efficacy trial of the Sanofipasteur live-attenuated tetravalent dengue vaccine (Dengvaxia), features of hospitalized disease accompanying dengue infections in placebo recipients were closely similar to those in vaccinated children. However, the age specific hospitalization curves for these two populations differed. The curve for children vaccinated at ages 2-16 years closely resembled the 1981 age specific hospitalization rate curve for Cuban children infected with DENV 2 who were sensitized by a prior DENV 1 infection...
October 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29020332/dependency-of-vaccine-efficacy-on-pre-exposure-and-age-a-closer-look-at-a-tetravalent-dengue-vaccine
#6
Yang Yang, Ya Meng, M Elizabeth Halloran, Ira M Longini
Background: A recombinant, live-attenuated, tetravalent dengue vaccine (CYD-TDV) was licensed for children of 9 years old or older in a few countries, but the dependence of vaccine efficacy on baseline immunity status and age groups has not been fully characterized. Methods: Combining the two phase III trials, CYD14 and CYD15, we estimated the vaccine efficacy for each of the four serotypes of dengue virus (DENV), as well as all serotypes combined, simultaneously stratified by baseline immunity status and age group, while accounting for uncertainty in the baseline immunity status of subjects...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28984261/factors-affecting-outcome-in-children-with-dengue-in-kolkata
#7
Ishita Majumdar, Devdeep Mukherjee, Ritabrata Kundu, Prabal Niyogi, Joydeep Das
This observational, descriptive study was conducted on 260 dengue patients diagnosed as per the revised 2009 WHO guidelines in a tertiary-care hospital of eastern India between June and November 2015. Children were evaluated for clinical symptoms, signs, and laboratory parameters. Clinical variables viz., rash, nausea/vomiting, bleeding, oliguria, capillary leak and liver enlargement; and laboratory variables viz., rising haemoglobin, haematocrit, thrombocytopenia, blood urea, serum Creatinine, ALT, hypo albuminemia and cholesterol were found to be significantly associated with outcome...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28975470/infections-of-the-central-nervous-system-in-returning-travelers-and-immigrants
#8
REVIEW
Haley Thompson, Kiran Thakur
PURPOSE OF REVIEW: This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS: Updates on travel vaccine recommendations including vaccine-specific interactions with immunosuppressive agents, advances in Zika virus and dengue virus vaccine development, new diagnostic criteria for neurocysticercosis, updates on treatment approaches for tuberculosis meningitis...
October 3, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28953902/immune-status-alters-the-probability-of-apparent-illness-due-to-dengue-virus-infection-evidence-from-a-pooled-analysis-across-multiple-cohort-and-cluster-studies
#9
Hannah E Clapham, Derek A T Cummings, Michael A Johansson
Dengue is an important vector-borne pathogen found across much of the world. Many factors complicate our understanding of the relationship between infection with one of the four dengue virus serotypes, and the observed incidence of disease. One of the factors is a large proportion of infections appear to result in no or few symptoms, while others result in severe infections. Estimates of the proportion of infections that result in no symptoms (inapparent) vary widely from 8% to 100%, depending on study and setting...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28918772/incidence-and-risk-factors-for-dengue-virus-denv-infection-in-the-first-2-years-of-life-in-a-brazilian-prospective-birth-cohort
#10
P M S Castanha, U R Montarroyos, S M M Silveira, G D M Albuquerque, M J G Mello, K G S Lopes, M T Cordeiro, E T A Marques, C M T Martelli, C Braga
This study assessed the incidence and risk factors for dengue virus (DENV) infection among children in a prospective birth cohort conducted in the city of Recife, a hyperendemic dengue area in Northeast Brazil. Healthy pregnant women (n = 415) residing in Recife who agreed to have their children followed were enrolled. Children were followed during their first 24 months of age (May/2011-June/2014), before the 2015 Zika virus outbreak. DENV infection was detected by reverse-transcriptase polymerase chain reaction and/or serology (anti-DENV IgM/IgG)...
October 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28893477/live-attenuated-tetravalent-dengue-vaccines-the-needs-and-challenges-of-post-licensure-evaluation-of-vaccine-safety-and-effectiveness
#11
REVIEW
Ole Wichmann, Kirsten Vannice, Edwin J Asturias, Expedito José de Albuquerque Luna, Ira Longini, Anna Lena Lopez, Peter G Smith, Hasitha Tissera, In-Kyu Yoon, Joachim Hombach
Since December 2015, the first dengue vaccine has been licensed in several Asian and Latin American countries for protection against disease from all four dengue virus serotypes. While the vaccine demonstrated an overall good safety and efficacy profile in clinical trials, some key research questions remain which make risk-benefit-assessment for some populations difficult. As for any new vaccine, several questions, such as very rare adverse events following immunization, duration of vaccine-induced protection and effectiveness when used in public health programs, will be addressed by post-licensure studies and by data from national surveillance systems after the vaccine has been introduced...
October 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28887788/the-clinical-and-serological-profile-of-pediatric-dengue
#12
Sujatha Ramabhatta, Saravanan Palaniappan, Navya Hanumantharayappa, Shaik Vajidunnisa Begum
OBJECTIVE: To classify suspected dengue into dengue, dengue with warning signs and severe dengue, based on clinical features as per the revised WHO guidelines with special emphasis on serology. METHODS: It was a prospective cross-sectional study for five years from 2011-2016 in a tertiary care medical college hospital in Bangalore. All cases of fever of three to five days duration with symptoms like dengue were enrolled for the study. They were categorized into three groups as per the Revised WHO 2012 criteria...
September 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28879600/infections-and-the-kidney-a-tale-from-the-tropics
#13
Nivedita Kamath, Arpana Iyengar
Tropical infections are caused by a variety of bacteria, viruses and parasitic organisms across varying geographical regions and are more often reported in adults than in children. Most of the infections are acute, presenting as a febrile illness with involvement of multiple organ systems, including the kidney. The gamut of renal manifestations extends from asymptomatic urinary abnormalities to acute kidney injury and-albeit rarely-chronic kidney disease. Tropical infections can involve the glomerular, tubulointerstitial and vascular compartments of the kidney...
September 6, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28873408/-we-need-people-to-collaborate-together-against-this-disease-a-qualitative-exploration-of-perceptions-of-dengue-fever-control-in-caregivers-of-children-under-5-years-in-the-peruvian-amazon
#14
Amy L Frank, Emily R Beales, Gilles de Wildt, Graciela Meza Sanchez, Laura L Jones
BACKGROUND: Dengue Fever presents a significant and growing burden of disease to endemic countries, where children are at particular risk. Worldwide, no effective anti-viral treatment has been identified, thus vector control is key for disease prevention, particularly in Peru where no vaccine is currently available. This qualitative study aimed to explore the perceptions of dengue control in caregivers' of children under 5 years in Peru, to help direct future mosquito control programmes and strategy...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28871961/genetic-epidemiology-of-dengue-viruses-in-phase-iii-trials-of-the-cyd-tetravalent-dengue-vaccine-and-implications-for-efficacy
#15
Maia A Rabaa, Yves Girerd-Chambaz, Kien Duong Thi Hue, Trung Vu Tuan, Bridget Wills, Matthew Bonaparte, Diane van der Vliet, Edith Langevin, Margarita Cortes, Betzana Zambrano, Corinne Dunod, Anh Wartel-Tram, Nicholas Jackson, Cameron P Simmons
This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, including at epitope sites targeted by virus neutralising human monoclonal antibodies...
September 5, 2017: ELife
https://www.readbyqxmd.com/read/28863466/characterization-of-dengue-virus-infections-among-febrile-children-clinically-diagnosed-with-a-non-dengue-illness-managua-nicaragua
#16
Jesse J Waggoner, Lionel Gresh, Alisha Mohamed-Hadley, Angel Balmaseda, K James Soda, Janaki Abeynayake, Malaya K Sahoo, Yuanyuan Liu, Guillermina Kuan, Eva Harris, Benjamin A Pinsky
Background: We sought to characterize dengue virus (DENV) infections among febrile children enrolled in a pediatric cohort study who were clinically diagnosed with a non-dengue illness ("C cases"). Methods: DENV infections were detected and viral load quantitated by real-time reverse transcription-polymerase chain reaction in C cases presenting between January 2007 and January 2013. Results: One hundred forty-one of 2892 C cases (4.88%) tested positive for DENV...
June 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28860941/dengue-virus-and-japanese-encephalitis-virus-infection-of-the-central-nervous-system-share-similar-profiles-of-cytokine-accumulation-in-cerebrospinal-fluid
#17
Haipeng Li, Yuanyuan Li, Bo Wen, Jian Zhang, Chengwu Wang, Zhanyi Song, Shuochi Li, Xiaowang Qu, Renbin Huang, Wenpei Liu
Dengue virus (DENV) and Japanese encephalitis virus (JEV) are two important pathogenic viruses that can cause severe encephalitis, which is accompanied by inflammatory cytokines. However, the inflammatory cytokine content of cerebrospinal fluid (CSF) in DENV and JEV infection of central nervous system are not sufficiently studied. To investigate cytokine levels in serum and CSF of hospitalised children with DENV and JEV infection of the central nervous system, a total of 183 hospitalised children with viral encephalitis-like syndrome were enrolled between May 2014 and April 2015 at the Children's Hospital of Chenzhou, Hunan, China...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28855396/increased-adaptive-immune-responses-and-proper-feedback-regulation-protect-against-clinical-dengue
#18
Etienne Simon-Lorière, Veasna Duong, Ahmed Tawfik, Sivlin Ung, Sowath Ly, Isabelle Casadémont, Matthieu Prot, Noémie Courtejoie, Kevin Bleakley, Philippe Buchy, Arnaud Tarantola, Philippe Dussart, Tineke Cantaert, Anavaj Sakuntabhai
Clinical symptoms of dengue virus (DENV) infection, the most prevalent arthropod-borne viral disease, range from classical mild dengue fever to severe, life-threatening dengue shock syndrome. However, most DENV infections cause few or no symptoms. Asymptomatic DENV-infected patients provide a unique opportunity to decipher the host immune responses leading to virus elimination without negative impact on an individual's health. We used an integrated approach of transcriptional profiling and immunological analysis to compare a Cambodian population of strictly asymptomatic viremic individuals with clinical dengue patients...
August 30, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28798927/is-dengue-emerging-as-important-cause-of-acute-liver-failure-in-endemic-regions
#19
Lavleen Singh, Amitabh Singh, Mitali Agarwal, Sataroopa Mishra
Dengue virus infection continues to be major public health problem in large part of world. The epidemiology of dengue viral infection is becoming increasingly complex and has substantially changed over almost past six decades not only in terms of prevalent strains and geographical locations but also in terms of disease severity and atypical presentations. Though liver is the most common organ affected but is generally asymptomatic. We present a case of infant with severe dengue who died of fulminant hepatic failure and showed pan lobular necrosis on post mortem liver biopsy...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28798738/zika-virus-an-emerging-worldwide-threat
#20
Irfan A Rather, Jameel B Lone, Vivek K Bajpai, Woon K Paek, Jeongheui Lim
ZIKA virus (ZIKV) poses a severe threat to the world. Recent outbreaks of ZIKV after 2007 along with its quick transmission have made this virus a matter of international concern. The virus shows symptoms that are similar to those caused in the wake of dengue virus (DENV) and other flaviviruses, which makes it difficult to discern the viral infection. Diagnosis is further complicated as the virus cross-reacts with antibodies of other viruses. Currently, molecular diagnosis of the virus is being performed by RT-PCR and IgM-captured enzyme-linked immunosorbent assay (MAC-ELISA)...
2017: Frontiers in Microbiology
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