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https://www.readbyqxmd.com/read/29223138/plant-expressed-fc-fusion-protein-tetravalent-dengue-vaccine-with-inherent-adjuvant-properties
#1
Mi Young Kim, Alastair Copland, Kaustuv Nayak, Anmol Chandele, Muhammad Shamsher Ahmed, Qibo Zhang, Gil Reynolds Diogo, Matthew John Paul, Sven Hofmann, Moon-Sik Yang, Yong-Suk Jang, Julian K-C Ma, Rajko Reljic
Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi-Pasteur Denvaxia vaccine does not protect children under the age of nine and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant-expression to produce a humanised and highly immunogenic Poly-Immunoglobulin G Scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity...
December 9, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29211830/antibiotic-utilization-and-the-role-of-suspected-and-diagnosed-mosquito-borne-illness-among-adults-and-children-with-acute-febrile-illness-in-pune-india
#2
Matthew Robinson, Dileep Kadam, Anju Kagal, Sandhya Khadse, Aarti Kinikar, Chhaya Valvi, Anita Basavaraj, Renu Bharadwaj, Ivan Marbaniang, Savita Kanade, Priyanka Raichur, Jonathan Sachs, Eili Klein, Sara Cosgrove, Amita Gupta, Vidya Mave
Background: Antibiotic resistance mechanisms originating in low- and middle- income countries are among the most common worldwide. Reducing unnecessary antibiotic use in India, the world's largest antibiotic consumer is crucial to control antimicrobial resistance globally. Limited data describing factors influencing Indian clinicians to start or stop antibiotics is available. Methods: Febrile adults and children admitted to a public tertiary care hospital in Pune, India were enrolled...
December 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29181956/infectious-diseases-in-poland-in-2015
#3
Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P. Czarkowski
PURPOSE OF THE STUDY: This is the next annual analysis of the situation of infectious and parasitic diseases in Poland in 2015 within the framework of the Epidemiological Chronicle of Przegląd Epidemiologiczny - Epidemiological Review. Its purpose is to identify potential threats to the health of populations from infectious diseases occurring in Poland with reference to other parts of the globe. MATERIAL AND METHODS: This paper is an introduction to more detailed studies of the epidemiological situation of selected infectious diseases and summarizes the results of the surveillance of infectious diseases in Poland in 2015...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29180056/review-of-a-licensed-dengue-vaccine-inappropriate-subgroup-analyses-and-selective-reporting-may-cause-harm-in-mass-vaccination-programs
#4
Antonio L Dans, Leonila F Dans, Mary Ann D Lansang, Maria Asuncion A Silvestre, Gordon H Guyatt
Severe life-threatening dengue fever usually occurs when a child is infected by dengue virus a 2nd time. This is caused by a phenomenon called antibody dependent enhancement or ADE. Since dengue vaccines can mimic a first infection in seronegative children (those with no previous infection), a natural infection later in life could lead to severe disease. The possibility that dengue vaccines can cause severe dengue through ADE has led to serious concern regarding the safety of mass vaccination programs. A published meta-analysis addressed this safety issue for a new vaccine against dengue fever - Dengvaxia ™...
November 24, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29122738/performance-of-a-mobile-phone-app-based-participatory-syndromic-surveillance-system-for-acute-febrile-illness-and-acute-gastroenteritis-in-rural-guatemala
#5
Daniel Olson, Molly Lamb, Maria Renee Lopez, Kathryn Colborn, Alejandra Paniagua-Avila, Alma Zacarias, Ricardo Zambrano-Perilla, Sergio Ricardo Rodríguez-Castro, Celia Cordon-Rosales, Edwin Jose Asturias
BACKGROUND: With their increasing availability in resource-limited settings, mobile phones may provide an important tool for participatory syndromic surveillance, in which users provide symptom data directly into a centralized database. OBJECTIVE: We studied the performance of a mobile phone app-based participatory syndromic surveillance system for collecting syndromic data (acute febrile illness and acute gastroenteritis) to detect dengue virus and norovirus on a cohort of children living in a low-resource and rural area of Guatemala...
November 9, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29122463/immunogenicity-and-safety-of-one-versus-two-doses-of-tetravalent-dengue-vaccine-in-healthy-children-aged-2-17-years-in-asia-and-latin-america-18-month-interim-data-from-a-phase-2-randomised-placebo-controlled-study
#6
Xavier Sáez-Llorens, Vianney Tricou, Delia Yu, Luis Rivera, José Jimeno, Ana Cecilia Villarreal, Epiphany Dato, Sonia Mazara, Maria Vargas, Manja Brose, Martina Rauscher, Suely Tuboi, Astrid Borkowski, Derek Wallace
BACKGROUND: Development of vaccines that are effective against all four dengue virus serotypes (DENV-1-4) in all age groups is important. Here, we present 18-month interim data from an ongoing study undertaken to assess the immunogenicity and safety of Takeda's tetravalent dengue vaccine (TDV) candidate over 48 months in children living in dengue-endemic countries. METHODS: We undertook a phase 2, multicentre, randomised, double-blind, placebo-controlled study at three sites in the Dominican Republic, Panama, and the Philippines...
November 6, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29122384/strengthening-global-vaccine-access-for-adolescents-and-adults
#7
REVIEW
Angeline Nanni, Stefanie Meredith, Stephanie Gati, Karin Holm, Tom Harmon, Ann Ginsberg
Global immunization efforts to date have heavily focused on infants and children, with noted success on public health. Healthy adolescents and adults contribute to the economic growth and development of countries but efforts to ensure vaccine coverage for these groups receive inadequate global attention and resources. Emerging epidemics for a number of infectious diseases including Ebola, Zika, dengue, malaria and the continuing epidemics of tuberculosis and several sexually transmitted infections, including HIV, HPV and Hepatitis B, have high incidence and prevalence in adolescents and adults...
November 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29119088/neurological-manifestations-of-dengue-infection
#8
REVIEW
Guo-Hong Li, Zhi-Jie Ning, Yi-Ming Liu, Xiao-Hong Li
Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide. Neurological signs of dengue infection are increasingly reported. In this review, the main neurological complications of dengue virus infection, such as central nervous system (CNS), peripheral nervous system, and ophthalmic complications were discussed according to clinical features, treatment and possible pathogenesis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29118655/the-burden-of-dengue-source-reduction-measures-and-serotype-patterns-in-myanmar-2011-to-2015-r2
#9
Pwint Mon Oo, Khin Thet Wai, Anthony D Harries, Hemant Deepak Shewade, Tin Oo, Aung Thi, Zaw Lin
Background: Myanmar is currently classified as a high burden dengue country in the Asian Pacific region. The Myanmar vector-borne diseases control (VBDC) program has collected data on dengue and source reduction measures since 1970, and there is a pressing need to collate, analyze, and interpret this information. The aim of this study was to describe the burden of hospital-based dengue disease, dengue control measures, and serotype patterns in Myanmar between 2011 and 2015. Methods: This was a cross-sectional study using annual records from the Dengue Fever/Dengue Hemorrhagic Fever Prevention and Control Project in Myanmar...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29116291/analysis-of-dengue-cases-according-to-clinical-severity-s%C3%A3-o-lu%C3%A3-s-maranh%C3%A3-o-brazil
#10
José de Jesus Dias, Maria Dos Remédios Freitas Carvalho Branco, Rejane Christine de Sousa Queiroz, Alcione Miranda Dos Santos, Emnielle Pinto Borges Moreira, Maria do Socorro da Silva
Severe dengue cases have increased in Brazil since 2001, with the first records in Maranhão dating back to 2002. The aim of this study was to determine the prevalence of severe dengue cases by age group and the possible risk factors. This was a study of secondary data on dengue in residents of São Luís, Maranhão, Brazil, using probable cases notified to the National Mandatory Reporting System (SINAN) from 2002 to 2011. The diagnosis and classification of dengue were based on the Brazilian Ministry of Health criteria: dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue fever with complications (DWC)...
November 6, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29078078/characterization-of-type-i-interferon-responses-in-dengue-and-severe-dengue-in-children-in-paraguay
#11
Laura B Talarico, Alana B Byrne, Sara Amarilla, Dolores Lovera, Cynthia Vázquez, Gustavo Chamorro, Patricio L Acosta, Adrián Ferretti, Mauricio T Caballero, Antonio Arbo, Fernando P Polack
BACKGROUND: Infection with dengue virus (DENV) produces a wide spectrum of clinical illness ranging from asymptomatic infection to mild febrile illness, and to severe forms of the disease. Type I interferons (IFNs) represent an initial and essential host defense response against viruses. DENV has been reported to trigger a robust type I IFN response; however, IFN-α/β profile in the progression of disease is not well characterized. OBJECTIVES AND STUDY DESIGN: In this context, we conducted a retrospective study assessing the circulating serum levels of type I IFNs and related cytokines at different phases of illness in children during the 2011 outbreak of DENV in Paraguay...
October 18, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29059411/clinical-and-laboratory-factors-associated-with-severe-dengue-a-case-control-study-of-hospitalized-children
#12
Mayumi Duarte Wakimoto, Luiz Antonio Bastos Camacho, Michelle Luiza Gonin, Patrícia Brasil
Background: More than half of the hospitalizations because of dengue in Brazil occurred in children <15 years of age in 2007 and 2008, an unexpected change in the epidemiological pattern. We sought to determine clinical and laboratory parameters associated with severity. Methods: A case-control study was conducted in three pediatric hospitals in Rio de Janeiro, Brazil; 233 laboratory-confirmed dengue patients were included: 69 cases and 164 controls. Specific clinical and laboratory factors were assessed using univariate and multivariate logistic regression models...
October 20, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29054571/associations-of-dc-sign-cd209-promoter-336g-a-polymorphism-rs4804803-with-dengue-infection-a-systematic-review-and-meta-analysis
#13
Noel Pabalan, Suwit Chaisri, Sompong Tabunhan, Achara Phumyen, Hamdi Jarjanazi, Theodore S Steiner
BACKGROUND AND AIM: Dengue virus entry into a host is associated with a cell surface protein, DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin). A common CD209-336G/A (rs4804803) polymorphism in DC-SIGN may affect severity of dengue virus infection (DEN) and incidence of dengue fever (DF) or the more severe dengue hemorrhagic fever (DHF). However, the reported associations of these two outcomes and CD-209 have been inconsistent, which prompted a meta-analysis to obtain more precise estimates...
October 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29048283/unrecognized-dengue-virus-infections-in-children-western-kenya-2014-2015
#14
David M Vu, Noah Mutai, Claire J Heath, John M Vulule, Francis M Mutuku, Bryson A Ndenga, A Desiree LaBeaud
We detected a cluster of dengue virus infections in children in Kenya during July 2014-June 2015. Most cases were serotype 1, but we detected all 4 serotypes, including co-infections with 2 serotypes. Our findings implicate dengue as a cause of febrile illness in this population and highlight a need for robust arbovirus surveillance.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29040262/serological-and-spatial-analysis-of-alphavirus-and-flavivirus-prevalence-and-risk-factors-in-a-rural-community-in-western-kenya
#15
Elysse N Grossi-Soyster, Elizabeth A J Cook, William A de Glanville, Lian F Thomas, Amy R Krystosik, Justin Lee, C Njeri Wamae, Samuel Kariuki, Eric M Fèvre, A Desiree LaBeaud
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5-14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29031286/surveillance-of-vector-borne-infections-chikungunya-dengue-and-malaria-in-bo-sierra-leone-2012-2013
#16
Donald F Dariano, Chris R Taitt, Kathryn H Jacobsen, Umaru Bangura, Alfred S Bockarie, Moses J Bockarie, Joseph Lahai, Joseph M Lamin, Tomasz A Leski, Chadwick Yasuda, David A Stenger, Rashid Ansumana
Malaria remains a significant cause of morbidity and mortality in West Africa, but the contribution of other vector-borne infections (VBIs) to the burden of disease has been understudied. We used rapid diagnostic tests (RDTs) for three VBIs to test blood samples from 1,795 febrile residents of Bo City, Sierra Leone, over a 1-year period in 2012-2013. In total, 24% of the tests were positive for malaria, fewer than 5% were positive for markers of dengue virus infection, and 39% were positive for IgM directed against chikungunya virus (CHIKV) or a related alphavirus...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29029938/dengvaxia-sensitizes-seronegatives-to-vaccine-enhanced-disease-regardless-of-age
#17
Scott B Halstead
During a large scale clinical efficacy trial of the Sanofipasteur live-attenuated tetravalent dengue vaccine (Dengvaxia), features of hospitalized disease accompanying dengue infections in placebo recipients were closely similar to those in vaccinated children. However, the age specific hospitalization curves for these two populations differed. The curve for children vaccinated at ages 2-16 years closely resembled the 1981 age specific hospitalization rate curve for Cuban children infected with DENV 2 who were sensitized by a prior DENV 1 infection...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29020332/dependency-of-vaccine-efficacy-on-pre-exposure-and-age-a-closer-look-at-a-tetravalent-dengue-vaccine
#18
Yang Yang, Ya Meng, M Elizabeth Halloran, Ira M Longini
Background: A recombinant, live-attenuated, tetravalent dengue vaccine (CYD-TDV) was licensed for children of 9 years old or older in a few countries, but the dependence of vaccine efficacy on baseline immunity status and age groups has not been fully characterized. Methods: Combining the two phase III trials, CYD14 and CYD15, we estimated the vaccine efficacy for each of the four serotypes of dengue virus (DENV), as well as all serotypes combined, simultaneously stratified by baseline immunity status and age group, while accounting for uncertainty in the baseline immunity status of subjects...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28984261/factors-affecting-outcome-in-children-with-dengue-in-kolkata
#19
Ishita Majumdar, Devdeep Mukherjee, Ritabrata Kundu, Prabal Niyogi, Joydeep Das
This observational, descriptive study was conducted on 260 dengue patients diagnosed as per the revised 2009 WHO guidelines in a tertiary-care hospital of eastern India between June and November 2015. Children were evaluated for clinical symptoms, signs, and laboratory parameters. Clinical variables viz., rash, nausea/vomiting, bleeding, oliguria, capillary leak and liver enlargement; and laboratory variables viz., rising haemoglobin, haematocrit, thrombocytopenia, blood urea, serum Creatinine, ALT, hypo albuminemia and cholesterol were found to be significantly associated with outcome...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28975470/infections-of-the-central-nervous-system-in-returning-travelers-and-immigrants
#20
REVIEW
Haley Thompson, Kiran Thakur
PURPOSE OF REVIEW: This review highlights current knowledge in travel-related neuroinfectious diseases, providing insight on approaches to prevention, diagnosis, and treatment of infections of the central nervous system (CNS) in travelers and immigrants. RECENT FINDINGS: Updates on travel vaccine recommendations including vaccine-specific interactions with immunosuppressive agents, advances in Zika virus and dengue virus vaccine development, new diagnostic criteria for neurocysticercosis, updates on treatment approaches for tuberculosis meningitis...
October 3, 2017: Current Infectious Disease Reports
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