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dengue in children

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https://www.readbyqxmd.com/read/29425194/evaluation-of-the-who-2009-classification-for-diagnosis-of-acute-dengue-in-a-large-cohort-of-adults-and-children-in-sri-lanka-during-a-dengue-1-epidemic
#1
Champica K Bodinayake, L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachchi, John J Strouse, October M Sessions, Ruvini Kurukulasooriya, Anna Uehara, Shiqin Howe, Xin Mei Ong, Sharon Tan, Angelia Chow, Praveen Tummalapalli, Aruna D De Silva, Truls Østbye, Christopher W Woods, Duane J Gubler, Megan E Reller
BACKGROUND: Dengue is a leading cause of fever and mimics other acute febrile illnesses (AFI). In 2009, the World Health Organization (WHO) revised criteria for clinical diagnosis of dengue. METHODOLOGY/PRINCIPAL FINDINGS: The new WHO 2009 classification of dengue divides suspected cases into three categories: dengue without warning signs, dengue with warning signs and severe dengue. We evaluated the WHO 2009 classification vs physicians' subjective clinical diagnosis (gestalt clinical impression) in a large cohort of patients presenting to a tertiary care center in southern Sri Lanka hospitalized with acute febrile illness...
February 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29422730/acute-renal-failure-adversely-affects-survival-in-pediatric-dengue-infection
#2
Biswanath Basu, Birendranath Roy
Aims: Dengue is currently one of the most important mosquito-borne viral infections. Acute renal failure (ARF) is a serious complication among children suffering from dengue infection. Subjects and Methods: A retrospective cohort review of baseline characteristics, disease outcomes, and risk factors of dengue-infected patients, with and without renal failure (RF), were compared. Results: Among 97 children with dengue, 13.4% had RF (estimated glomerular filtration rate <60 ml/min/1...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29415036/the-association-between-obesity-and-dengue-severity-among-pediatric-patients-a-systematic-review-and-meta-analysis
#3
Mohd Syis Zulkipli, Maznah Dahlui, Nor'ashikin Jamil, Devi Peramalah, Victor Hoe Chee Wai, Awang Bulgiba, Sanjay Rampal
BACKGROUND: Severe dengue infection often has unpredictable clinical progressions and outcomes. Obesity may play a role in the deterioration of dengue infection due to stronger body immune responses. Several studies found that obese dengue patients have a more severe presentation with a poorer prognosis. However, the association was inconclusive due to the variation in the results of earlier studies. Therefore, we conducted a systematic review and meta-analysis to explore the relationship between obesity and dengue severity...
February 7, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29410208/trends-in-insect-repellent-formulations-a-review
#4
REVIEW
Melanie Tavares, Márcio Robert Mattos da Silva, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Lolita Bodjolle-d'Almeira, Elisabete Pereira Dos Santos, Eduardo Ricci-Junior
The use of natural and synthetic repellents, marketed in different pharmaceutical forms, is growing in the world due to the emerging vector-borne viral diseases as Dengue, Zika, Chikungunya, Yellow Fever and Malaria. The choice of the ideal formulation will depend on a series of factors to be analyzed: type of repellent active (natural or synthetic), pharmaceutical forms (spray, lotion, cream, gel), action time duration (short or long), environment of exposure and the user (adult, pregnant women, children, newborn)...
February 2, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29408333/four-year-safety-follow-up-of-the-tetravalent-dengue-vaccine-efficacy-randomised-controlled-trials-in-asia-and-latin-america
#5
José Luis Arredondo-García, Sri Rezeki Hadinegoro, Humberto Reynales, Mary Noreen Chua, Doris Maribel Rivera Medina, Tawee Chotpitayasunondh, Ngoc Huu Tran, Carmen C Deseda, Dewa Nyoman Wirawan, Margarita Cortés Supelano, Carina Frago, Edith Langevin, Diana Coronel, Thelma Laot, Ana Paula Perroud, Leilani Sanchez, Matthew Bonaparte, Kriengsak Limkittikul, Danaya Chansinghakul, Sophia Gailhardou, Fernando Noriega, T Anh Wartel, Alain Bouckenooghe, Betzana Zambrano
Objective; Our objective was to describe the risk of hospital admission for virologically-confirmed dengue (VCD) and the risk of clinically-severe hospitalised VCD occurring up to four years post-first dose (Years 1 to 4) in three randomised clinical trials comparing tetravalent dengue vaccine to placebo. Methods; The RRs (relative risks) for hospitalised VCD from first dose to Year-4 were estimated by year and age-group in individual and combined studies. Results; Overall, from Year-1 to Year-4, 233 and 228 participants had ≥1 episode of hospitalised VCD in the vaccinated (N=22,603) and placebo groups (N=11,301), respectively (RR=0...
February 2, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29406974/fever-in-the-returning-traveler
#6
REVIEW
Felicia A Scaggs Huang, Elizabeth Schlaudecker
Millions of children travel annually, whether they are refugees, international adoptees, visitors, or vacationers. Although most young travelers do well, many develop a febrile illness during or shortly after their trips. Approaching a fever in the returning traveler requires an appropriate index of suspicion to diagnose and treat in a timely manner. As many as 34% of patients with recent travel history are diagnosed with routine infections, but serious infections such as malaria, enteric fever, and dengue fever should be on the differential diagnosis due the high morbidity and mortality in children...
March 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29405145/aetiological-study-of-viruses-causing-acute-encephalitis-syndrome-in-north-west-india
#7
Jitendra Kumar Tiwari, Bharti Malhotra, Aradhana Chauhan, Hemant Malhotra, Pratibha Sharma, Farah Deeba, Khushbu Trivedi, Anjenya M Swamy
CONTEXT: Acute encephalitis syndrome (AES) is a serious public health problem, caused mainly by viruses. However, the profile of viruses causing AES in Rajasthan is not well characterised. AIMS: The present study was undertaken to identify the viruses causing AES and develop diagnostic algorithm so as to help in improved diagnosis, treatment, prevention and control. SETTINGS AND DESIGN: The present study is a hospital-based descriptive, observational study...
October 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29404200/comparative-proteomics-reveals-that-yk51-a-4-hydroxypandurantin-a-analogue-downregulates-the-expression-of-proteins-associated-with-dengue-virus-infection
#8
Wei-Lian Tan, Yean Kee Lee, Yen Fong Ho, Rohana Yusof, Noorsaadah Abdul Rahman, Saiful Anuar Karsani
Dengue is endemic throughout tropical and subtropical regions of the world. Currently, there is no clinically approved therapeutic drug available for this acute viral infection. Although the first dengue vaccine Dengvaxia has been approved for use in certain countries, it is limited to those without a previous dengue infection while the safety and efficacy of the vaccine in those elderly and younger children still need to be identified. Therefore, it is becoming increasingly important to develop therapeutics/drugs to combat dengue virus (DENV) infection...
2018: PeerJ
https://www.readbyqxmd.com/read/29396004/development-of-vaccines-against-zika-virus
#9
REVIEW
Gregory A Poland, Richard B Kennedy, Inna G Ovsyannikova, Ricardo Palacios, Paulo Lee Ho, Jorge Kalil
Zika virus is an emerging pathogen of substantial public health concern to human beings. Although most infections are asymptomatic or present with benign, self-limited symptoms, a small percentage of patients have complications, such as congenital anomalies in the developing fetus of pregnant women infected with the virus and neurological complications (eg, Guillain-Barré syndrome). To date, there is no vaccine, antiviral drug, or other modality available to prevent or treat Zika virus infection. In this Review, we examine vaccine development efforts for Zika virus to date and research gaps in the development of candidate vaccines against Zika virus...
January 25, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29390091/identification-and-characterization-at-the-single-cell-level-of-cytokine-producing-circulating-cells-in-children-with-dengue
#10
Federico Perdomo-Celis, Felipe Romero, Doris M Salgado, Rocío Vega, Jairo Rodríguez, Juana Angel, Manuel A Franco, Harry B Greenberg, Carlos F Narváez
In this study we identified, at the single-cell level, naturally induced cytokine-producing circulating cells (CPCC) in children with dengue virus (DENV) infection ranging clinically from mild to severe disease. Tumor necrosis factor (TNF)-α- and Interleukin (IL)-6-CPCC were detected in children with primary or secondary acute DENV infection and the pattern of these cytokines was similar to that seen in the supernatant of cultured PBMC and partially comparable to that found in the plasma. Monocytes, B cells (BC), and myeloid dendritic cells (mDC) were the primary CPCC detected, and the frequency of mDC was significantly higher in severe disease...
January 30, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29364411/-prevention-diagnosis-and-treatment-of-pediatric-infections-during-natural-disasters
#11
Flavia Morán, Theresa J Ochoa
The objective of this review was to provide guidelines regarding the diagnosis, treatment, and prevention of the most common infectious diseases in children during natural disasters, including floods such as those that occurred in the summer of 2017 in Peru. This instrument should be used by physicians and health personnel working in primary health care. The management of diarrheal, respiratory, skin, and eye diseases, vector-transmitted diseases such as dengue, chikungunya, and Zika, and zoonoses such as leptospirosis is discussed...
October 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29344875/development-of-a-prognostic-prediction-model-to-determine-severe-dengue-in-children
#12
Priya Sreenivasan, Geetha S, Sasikala K
OBJECTIVE: To develop a prognostic prediction model using the seven warning signs highlighted by WHO revised Dengue fever classification 2009 to determine severe dengue in children. METHODS: In this prospective analytical study conducted in a tertiary care centre, consecutive sampling of all children aged 1mo to 12y admitted with serologically confirmed Dengue was done from May 2015 through August 2016. After excluding 27 patients with co-infections and co-morbidities, 359 patients were followed up daily to assess clinical and laboratory progression till discharge/ death...
January 18, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29338803/socio-demographic-inequalities-in-the-clinical-characteristics-of-dengue-haemorrhagic-fever-in-the-city-of-rio-de-janeiro-brazil-2007-2008
#13
Sheila Moura Pone, Yara Hahr Marques Hökerberg, Patricia Brasil, Cecília Carmen de Araújo Nicolai, Rogério Ferrari, Raquel de Vasconcellos Carvalhaes de Oliveira
In 2007-2008, the city of Rio de Janeiro underwent an epidemiological change, with increases in the incidence in children and in severe forms of dengue. To describe the clinical profile and spatial distribution of dengue we performed an ecological study based on dengue surveillance data using the Brazilian classification (2005): dengue fever, dengue haemorrhagic fever (DHF) and dengue with complications. χ 2 test was used to describe the clinical and socio-demographic variables (P < 0.05). Spatial distribution of incidence and case-fatality was explored with thematic maps, Moran and Geary indices (P < 0...
February 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29331246/estimation-of-expected-dengue-seroprevalence-from-passive-epidemiological-surveillance-systems-in-selected-areas-of-argentina-a-proxy-to-evaluate-the-applicability-of-dengue-vaccination
#14
Pablo Orellano, Darío Vezzani, Nancy Quaranta, Julieta Reynoso, Oscar Daniel Salomón
BACKGROUND: Current recommendations about dengue vaccination by the World Health Organization depend on seroprevalence levels and serological status in populations and individuals. However, seroprevalence estimation may be difficult due to a diversity of factors. Thus, estimation through models using data from epidemiological surveillance systems could be an alternative procedure to achieve this goal. OBJECTIVE: To estimate the expected dengue seroprevalence in children of selected areas in Argentina, using a simple model based on data from passive epidemiological surveillance systems...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29313471/epidemiological-serological-and-virological-features-of-dengue-in-nha-trang-city-vietnam
#15
Duong Le Quyen, Nguyen Thanh Le, Cao Thi Van Anh, Nguyen Binh Nguyen, Dong Van Hoang, Jacqui L Montgomery, Simon C Kutcher, Nguyen Hoang Le, Nguyen Tran Hien, Duong Thi Hue Kien, Maia Rabaa, Scott L O'Neill, Cameron P Simmons, Dang Duc Anh, Katherine L Anders
Vietnam is endemic for dengue. We conducted a series of retrospective and prospective studies to characterize the epidemiology of dengue and population mobility patterns in Nha Trang city, Vietnam, with a view to rational design of trials of community-level interventions. A 10-year time series of dengue case notifications showed pronounced interannual variability, as well as spatial heterogeneity in ward-level dengue incidence (median annual coefficient of variation k = 0.47). Of 451 children aged 1-10 years enrolled in a cross-sectional serosurvey, almost one-third had evidence of a past dengue virus (DENV) infection, with older children more likely to have a multitypic response indicative of past exposure to ≥ 1 serotype...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29300876/impact-of-dengue-vaccination-on-serological-diagnosis-insights-from-phase-iii-dengue-vaccine-efficacy-trials
#16
Eric Plennevaux, Annick Moureau, José L Arredondo-García, Luis Villar, Punnee Pitisuttithum, Ngoc H Tran, Matthew Bonaparte, Danaya Chansinghakul, Diana L Coronel, Maïna L'Azou, R Leon Ochiai, Myew-Ling Toh, Fernando Noriega, Alain Bouckenooghe
Background: We previously reported that vaccination with the tetravalent dengue vaccine (CYD-TDV; Dengvaxia) may bias the diagnosis of dengue based on immunoglobulin M (IgM) and immunoglobulin G (IgG) assessments. Methods: We undertook a post hoc pooled analysis of febrile episodes that occurred during the active surveillance phase (the 25 months after the first study injection) of 2 pivotal phase III, placebo-controlled CYD-TDV efficacy studies that involved ≥31000 children aged 2-16 years across 10 countries in Asia and Latin America...
December 30, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29280432/a-combined-syndromic-approach-to-examine-viral-bacterial-and-parasitic-agents-among-febrile-patients-a-pilot-study-in-kilombero-tanzania
#17
Christine Hercik, Leonard Cosmas, Ondari D Mogeni, Newton Wamola, Wanze Kohi, Eric Houpt, Jie Liu, Caroline Ochieng, Clayton Onyango, Barry Fields, Sayoki Mfinanga, Joel M Montgomery
The use of fever syndromic surveillance in sub-Saharan Africa is an effective approach to determine the prevalence of both malarial and nonmalarial infectious agents. We collected both blood and naso/oro-pharyngeal (NP/OP) swabs from consecutive consenting patients ≥ 1 year of age, with an axillary temperature ≥ 37.5°C, and symptom onset of ≤ 5 days. Specimens were analyzed using both acute febrile illness (AFI) and respiratory TaqMan array cards (TAC) for multiagent detection of 56 different bloodstream and respiratory agents...
December 26, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29235427/dengue-hospitalisations-in-brazil-annual-wave-from-west-to-east-and-recent-increase-among-children
#18
J Wunderlich, R Acuña-Soto, W J Alonso
The number of dengue epidemics in Brazil has increased dramatically in the last 15 years. In this study, we analysed the seasonal patterns in the incidence of hospitalisations due to dengue across the different states of Brazil and compared these with the corresponding climatic patterns. We discovered that the seasonality of dengue hospitalisations in Brazil has a clear zonal gradient, characterised by the progression of primary peaks from West to East during the first half of the year, which may be associated with the increased vapour pressure and rainfall during this period, leading to increased mosquito abundance and activity...
December 13, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29233744/a-flavonoid-compound-library-screen-revealed-potent-antiviral-activity-of-plant-derived-flavonoids-on-human-enterovirus-a71-replication
#19
Nyo Min, Leong Pok Thim, Regina Ching Hua Lee, Jeffery Seng Eng Khuan, Justin Jang Hann Chu
Hand Foot Mouth Disease (HFMD), resulting from human enterovirus A71 (HEVA71) infection can cause severe neurological complications leading to fatality in young children. Currently, there is no approved antiviral for therapeutic treatment against HEVA71 infection. In this study, a 500-compound flavonoid library was screened to identify potential inhibitors of HEVA71 using high-throughput immunofluorescence-based phenotypic screening method. Two lead flavonoid compounds, ST077124 and ST024734 at the non-cytotoxic concentration of 50 μM were found to be effective antivirals that inhibited replication of HEVA71, reducing infectious viral titers by 3...
December 9, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29223138/plant-expressed-fc-fusion-protein-tetravalent-dengue-vaccine-with-inherent-adjuvant-properties
#20
Mi Young Kim, Alastair Copland, Kaustuv Nayak, Anmol Chandele, Muhammad Shamsher Ahmed, Qibo Zhang, Gil Reynolds Diogo, Matthew John Paul, Sven Hofmann, Moon-Sik Yang, Yong-Suk Jang, Julian K-C Ma, Rajko Reljic
Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi-Pasteur Denvaxia vaccine does not protect children under the age of nine and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant-expression to produce a humanised and highly immunogenic Poly-Immunoglobulin G Scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity...
December 9, 2017: Plant Biotechnology Journal
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