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https://www.readbyqxmd.com/read/29655390/long-term-epidemiological-dynamics-of-dengue-in-barbados-one-of-the-english-speaking-caribbean-countries
#1
A Kumar, M Gittens-St Hilaire, A L Nielsen
Using the dengue surveillance program, we prospectively collected data on all the suspected and confirmed cases of dengue in Barbados from 2006 to 2015. Data were analysed for demographic, seasonal and temporal dynamics of this disease in this country. The overall mean annual incidence rate of suspected and confirmed dengue over the study period was 0.49% (range 0.15%-0.99%) and 0.16% (range 0.05%-0.48%), respectively. There was a significant correlation between the mean monthly number of confirmed cases, the mean monthly rainfall and the mean monthly relative humidity percentage...
April 15, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29609533/prolonged-persistence-of-igm-against-dengue-virus-detected-by-commonly-used-commercial-assays
#2
Yu-Wen Chien, Zi-Hu Liu, Fan-Chen Tseng, Tzu-Chuan Ho, How-Ran Guo, Nai-Ying Ko, Wen-Chien Ko, Guey Chuen Perng
BACKGROUND: Initial symptoms of dengue fever are non-specific, and thus definite diagnosis requires laboratory confirmation. Detection of IgM against dengue virus (DENV) has become widely used for dengue diagnosis. Understanding the persistence of anti-DENV IgM in subjects after acute infection is essential in order to interpret test results correctly. Although the longevity of anti-DENV IgM has been vehemently investigated in symptomatic children, anti-DENV IgM persistence in adults and in asymptomatically infected people have seldom been reported...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29582731/vector-borne-disease-is-a-common-cause-of-hospitalized-febrile-illness-in-india
#3
Matthew L Robinson, Dileep Kadam, Sandhya Khadse, Usha Balasubramanian, Priyanka Raichur, Chhaya Valvi, Ivan Marbaniang, Savita Kanade, Jonathan Sachs, Anita Basavaraj, Renu Bharadwaj, Anju Kagal, Vandana Kulkarni, Jonathan Zenilman, George Nelson, Yukari C Manabe, Aarti Kinikar, Amita Gupta, Vidya Mave
Acute febrile illness (AFI) is a major cause of morbidity and mortality in India and other resource-limited settings, yet systematic etiologic characterization of AFI has been limited. We prospectively enrolled adults ( N = 970) and children (age 6 months to 12 years, N = 755) admitted with fever from the community to Sassoon General Hospital in Pune, India, from July 2013 to December 2015. We systematically performed a standardized clinical history, clinical laboratories, and diagnostics. Results from additional testing ordered by treating clinicians were also recorded...
March 26, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29581051/febrile-illness-in-asia-gaps-in-epidemiology-diagnosis-management-for-informing-health-policy
#4
REVIEW
Poojan Shrestha, Tamalee Roberts, Anousin Homsana, Tin Ohn Myat, John A Crump, Yoel Lubell, Paul N Newton
BACKGROUND: There is increasing evidence on the aetiology and management of fevers in Asia, the importance of which has risen with declines in malaria incidence. AIMS: To conduct a narrative review of the epidemiology and management of fevers in South and South-East Asia and to highlight gaps in our knowledge that impair evidence-based health policy decisions. SOURCES: A narrative review of papers published since 2012 of developments in fever epidemiology, diagnosis and treatment in South and South-East Asia...
March 23, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29564154/severity-and-burden-of-hand-foot-and-mouth-disease-in-asia-a-modelling-study
#5
Wee Ming Koh, Hishamuddin Badaruddin, Hanh La, Mark I-Cheng Chen, Alex R Cook
Background: Hand, foot and mouth disease (HFMD) affects millions of children across Asia annually, leading to an increase in implemented control policies such as surveillance, isolation and social distancing in affected jurisdictions. However, limited knowledge of disease burden and severity causes difficulty in policy optimisation as the associated economic cost cannot be easily estimated. We use a data synthesis approach to provide a comprehensive picture of HFMD disease burden, estimating infection risk, symptomatic rates, the risk of complications and death, and overall disability-adjusted life-year (DALY) losses, along with associated uncertainties...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29562870/sleep-eeg-of-microcephaly-in-zika-outbreak
#6
Paulo Afonso Medeiros Kanda, Aline de Almeida Xavier Aguiar, Jose Lucivan Miranda, Alexandre Loverde Falcao, Claudia Suenia Andrade, Luigi Neves Dos Santos Reis, Ellen White R Bacelar Almeida, Yanes Brum Bello, Arthur Monfredinho, Rafael Guimaraes Kanda
Microcephaly (MC), previously considered rare, is now a health emergency of international concern because of the devastating Zika virus pandemic outbreak of 2015. The authors describe the electroencephalogram (EEG) findings in sleep EEG of epileptic children who were born with microcephaly in areas of Brazil with active Zika virus transmission between 2014 and 2017. The authors reviewed EEGs from 23 children. Nine were females (39.2%), and the age distribution varied from 4 to 48 months. MC was associated with mother positive serology to toxoplasmosis (toxo), rubella (rub), herpes, and dengue (1 case); toxo (1 case); chikungunya virus (CHIKV) (1 case); syphilis (1 case); and Zika virus (ZIKV) (10 cases)...
2018: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/29546926/-perinatal-dengue-a-case-report
#7
Ramiro Manzano Núñez, James Alejandro Zapata, Herney A García-Perdomo, Diego A Gomez, Mónica A Solís Velasco
INTRODUCTION: Few reports are available about perinatal dengue, with controversial results in regards the risk of perinatal outcome. OBJECTIVE: To report a case of perinatal dengue as a differential diagno sis with neonatal sepsis, which must be considered in endemic areas. CLINICAL CASE: Male newborn of a 23 year-old female, who presented a Non-Structural Protein 1 (NS1) antigen positive to dengue at 36 weeks of gestation and negative anti-dengue antibodies...
December 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29534694/predicting-the-severity-of-dengue-fever-in-children-on-admission-based-on-clinical-features-and-laboratory-indicators-application-of-classification-tree-analysis
#8
Khansoudaphone Phakhounthong, Pimwadee Chaovalit, Podjanee Jittamala, Stuart D Blacksell, Michael J Carter, Paul Turner, Kheng Chheng, Soeung Sona, Varun Kumar, Nicholas P J Day, Lisa J White, Wirichada Pan-Ngum
BACKGROUND: Dengue fever is a re-emerging viral disease commonly occurring in tropical and subtropical areas. The clinical features and abnormal laboratory test results of dengue infection are similar to those of other febrile illnesses; hence, its accurate and timely diagnosis for providing appropriate treatment is difficult. Delayed diagnosis may be associated with inappropriate treatment and higher risk of death. Early and correct diagnosis can help improve case management and optimise the use of resources such as hospital staff, beds, and intensive care equipment...
March 13, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29531658/clinical-and-hematological-profile-of-patients-with-dengue-fever-at-a-tertiary-care-hospital-an-observational-study
#9
Kunal Tewari, Vishal Vishnu Tewari, Ritu Mehta
Background: Dengue is a major health issue with seasonal rise in dengue fever cases imposing an additional burden on hospitals, necessitating bolstering of services in the emergency department, laboratory with creation of additional dengue fever wards. Objectives: To study the clinical and hematological profile of dengue fever cases presenting to a hospital. Methods: Patients with fever and other signs of dengue with either positive NS1 antigen test or IgM or IgG antibody were included...
2018: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29512482/the-burden-of-dengue-fever-and-chikungunya-in-southern-coastal-ecuador-epidemiology-clinical-presentation-and-phylogenetics-from-the-first-two-years-of-a-prospective-study
#10
Anna M Stewart-Ibarra, Sadie J Ryan, Aileen Kenneson, Christine A King, Mark Abbott, Arturo Barbachano-Guerrero, Efraín Beltrán-Ayala, Mercy J Borbor-Cordova, Washington B Cárdenas, Cinthya Cueva, Julia L Finkelstein, Christina D Lupone, Richard G Jarman, Irina Maljkovic Berry, Saurabh Mehta, Mark Polhemus, Mercy Silva, Timothy P Endy
Here, we report the findings from the first 2 years of an arbovirus surveillance study conducted in Machala, Ecuador, a dengue-endemic region (2014-2015). Patients with suspected dengue virus (DENV) infections (index cases, N = 324) were referred from five Ministry of Health clinical sites. A subset of DENV-positive index cases ( N = 44) were selected, and individuals from the index household and four neighboring homes within 200 m were recruited ( N = 400). Individuals who entered the study, other than the index cases, are referred to as associates...
March 5, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29499698/identification-of-priority-health-conditions-for-field-based-screening-in-urban-slums-in-bangalore-india
#11
Sarah Abdi, Avanti Wadugodapitiya, Sandra Bedaf, Carolin Elizabeth George, Gift Norman, Mark Hawley, Luc de Witte
BACKGROUND: Urban slums are characterised by unique challenging living conditions, which increase their inhabitants' vulnerability to specific health conditions. The identification and prioritization of the key health issues occurring in these settings is essential for the development of programmes that aim to enhance the health of local slum communities effectively. As such, the present study sought to identify and prioritise the key health issues occurring in urban slums, with a focus on the perceptions of health professionals and community workers, in the rapidly growing city of Bangalore, India...
March 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29482433/safety-issues-from-a-phase-3-clinical-trial-of-a-live-attenuated-chimeric-yellow-fever-tetravalent-dengue-vaccine
#12
Scott B Halstead
A tetravalent live-attenuated 3-dose vaccine composed of chimeras of yellow fever 17D and the four dengue viruses (CYD, also called Dengvaxia) completed phase 3 clinical testing in over 35,000 children leading to a recommendation that vaccine be administered to >/ = 9 year-olds residing in highly dengue- endemic countries. When clinical trial results were assessed 2 years after the first dose, vaccine efficacy among seropositives was high, but among seronegatives efficacy was marginal. Breakthrough dengue hospitalizations of vaccinated children occurred continuously over a period of 4-5 years post 3rd dose in an age distribution suggesting these children had been vaccinated when seronegative...
February 26, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29460714/seroprevalence-of-dengue-antibodies-in-three-urban-settings-in-yucatan-mexico
#13
Norma Pavía-Ruz, Diana Patricia Rojas, Salja Villanueva, Pilar Granja, Angel Balam-May, Ira M Longini, M Elizabeth Halloran, Pablo Manrique, Hector Gómez-Dantés
Dengue transmission in Mexico has become a major public health problem. Few epidemiological studies have examined the seroprevalence of dengue in Mexico, and recent estimates are needed to better understand dengue transmission dynamics. We conducted a dengue seroprevalence survey among 1,668 individuals including all age groups in three urban settings in Yucatan, Mexico. Children (< 19 years old) were selected randomly from schools. The adults (≥ 19 years old) were selected from healthcare facilities. Participants were asked to provide a venous blood sample and to answer a brief questionnaire with demographic information...
February 19, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29425194/evaluation-of-the-who-2009-classification-for-diagnosis-of-acute-dengue-in-a-large-cohort-of-adults-and-children-in-sri-lanka-during-a-dengue-1-epidemic
#14
Champica K Bodinayake, L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachchi, John J Strouse, October M Sessions, Ruvini Kurukulasooriya, Anna Uehara, Shiqin Howe, Xin Mei Ong, Sharon Tan, Angelia Chow, Praveen Tummalapalli, Aruna D De Silva, Truls Østbye, Christopher W Woods, Duane J Gubler, Megan E Reller
BACKGROUND: Dengue is a leading cause of fever and mimics other acute febrile illnesses (AFI). In 2009, the World Health Organization (WHO) revised criteria for clinical diagnosis of dengue. METHODOLOGY/PRINCIPAL FINDINGS: The new WHO 2009 classification of dengue divides suspected cases into three categories: dengue without warning signs, dengue with warning signs and severe dengue. We evaluated the WHO 2009 classification vs physicians' subjective clinical diagnosis (gestalt clinical impression) in a large cohort of patients presenting to a tertiary care center in southern Sri Lanka hospitalized with acute febrile illness...
February 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29422730/acute-renal-failure-adversely-affects-survival-in-pediatric-dengue-infection
#15
Biswanath Basu, Birendranath Roy
Aims: Dengue is currently one of the most important mosquito-borne viral infections. Acute renal failure (ARF) is a serious complication among children suffering from dengue infection. Subjects and Methods: A retrospective cohort review of baseline characteristics, disease outcomes, and risk factors of dengue-infected patients, with and without renal failure (RF), were compared. Results: Among 97 children with dengue, 13.4% had RF (estimated glomerular filtration rate <60 ml/min/1...
January 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29415036/the-association-between-obesity-and-dengue-severity-among-pediatric-patients-a-systematic-review-and-meta-analysis
#16
Mohd Syis Zulkipli, Maznah Dahlui, Nor'ashikin Jamil, Devi Peramalah, Hoe Victor Chee Wai, Awang Bulgiba, Sanjay Rampal
BACKGROUND: Severe dengue infection often has unpredictable clinical progressions and outcomes. Obesity may play a role in the deterioration of dengue infection due to stronger body immune responses. Several studies found that obese dengue patients have a more severe presentation with a poorer prognosis. However, the association was inconclusive due to the variation in the results of earlier studies. Therefore, we conducted a systematic review and meta-analysis to explore the relationship between obesity and dengue severity...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29410208/trends-in-insect-repellent-formulations-a-review
#17
REVIEW
Melanie Tavares, Márcio Robert Mattos da Silva, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Lolita Bodjolle-d'Almeida, Elisabete Pereira Dos Santos, Eduardo Ricci-Júnior
The use of natural and synthetic repellents, marketed in different pharmaceutical forms, is growing in the world due to the emerging vector-borne viral diseases as Dengue, Zika, Chikungunya, Yellow Fever and Malaria. The choice of the ideal formulation will depend on a series of factors to be analyzed: type of repellent active (natural or synthetic), pharmaceutical forms (spray, lotion, cream, gel), action time duration (short or long), environment of exposure and the user (adult, pregnant women, children, newborn)...
March 25, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29408333/four-year-safety-follow-up-of-the-tetravalent-dengue-vaccine-efficacy-randomised-controlled-trials-in-asia-and-latin-america
#18
José Luis Arredondo-García, Sri Rezeki Hadinegoro, Humberto Reynales, Mary Noreen Chua, Doris Maribel Rivera Medina, Tawee Chotpitayasunondh, Ngoc Huu Tran, Carmen C Deseda, Dewa Nyoman Wirawan, Margarita Cortés Supelano, Carina Frago, Edith Langevin, Diana Coronel, Thelma Laot, Ana Paula Perroud, Leilani Sanchez, Matthew Bonaparte, Kriengsak Limkittikul, Danaya Chansinghakul, Sophia Gailhardou, Fernando Noriega, T Anh Wartel, Alain Bouckenooghe, Betzana Zambrano
Objective; Our objective was to describe the risk of hospital admission for virologically-confirmed dengue (VCD) and the risk of clinically-severe hospitalised VCD occurring up to four years post-first dose (Years 1 to 4) in three randomised clinical trials comparing tetravalent dengue vaccine to placebo. Methods; The RRs (relative risks) for hospitalised VCD from first dose to Year-4 were estimated by year and age-group in individual and combined studies. Results; Overall, from Year-1 to Year-4, 233 and 228 participants had ≥1 episode of hospitalised VCD in the vaccinated (N=22,603) and placebo groups (N=11,301), respectively (RR=0...
February 2, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29406974/fever-in-the-returning-traveler
#19
REVIEW
Felicia A Scaggs Huang, Elizabeth Schlaudecker
Millions of children travel annually, whether they are refugees, international adoptees, visitors, or vacationers. Although most young travelers do well, many develop a febrile illness during or shortly after their trips. Approaching a fever in the returning traveler requires an appropriate index of suspicion to diagnose and treat in a timely manner. As many as 34% of patients with recent travel history are diagnosed with routine infections, but serious infections such as malaria, enteric fever, and dengue fever should be on the differential diagnosis due the high morbidity and mortality in children...
March 2018: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29405145/aetiological-study-of-viruses-causing-acute-encephalitis-syndrome-in-north-west-india
#20
Jitendra Kumar Tiwari, Bharti Malhotra, Aradhana Chauhan, Hemant Malhotra, Pratibha Sharma, Farah Deeba, Khushbu Trivedi, Anjenya M Swamy
CONTEXT: Acute encephalitis syndrome (AES) is a serious public health problem, caused mainly by viruses. However, the profile of viruses causing AES in Rajasthan is not well characterised. AIMS: The present study was undertaken to identify the viruses causing AES and develop diagnostic algorithm so as to help in improved diagnosis, treatment, prevention and control. SETTINGS AND DESIGN: The present study is a hospital-based descriptive, observational study...
October 2017: Indian Journal of Medical Microbiology
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