keyword
https://read.qxmd.com/read/38447505/effect-of-testosterone-replacement-therapy-on-scar-quality-in-gender-affirming-mastectomies
#21
JOURNAL ARTICLE
Yoram Wolf, Ron Skorochod, Shady Elias
BACKGROUND: The term transgenders refer to people who sense discordance between their gender identity and the sex assigned to them at birth. Some transgenders receive hormonal therapy, which may lead to specific skin conditions. The purpose of the present study was to determine whether a causal relationship exists between hormonal therapy (specifically testosterone therapy) and unsatisfying surgical scarring, including hypertrophic and keloid scars. In addition, this study may serve as a basis for future studies, which may test means that aim to reduce such undesired effects...
February 1, 2024: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://read.qxmd.com/read/38444635/the-role-of-the-skin-microbiome-in-wound-healing
#22
REVIEW
Yuyan Yang, Jiuzuo Huang, Ang Zeng, Xiao Long, Nanze Yu, Xiaojun Wang
The efficient management of skin wounds for rapid and scarless healing represents a major clinical unmet need. Nonhealing skin wounds and undesired scar formation impair quality of life and result in high healthcare expenditure worldwide. The skin-colonizing microbiota contributes to maintaining an intact skin barrier in homeostasis, but it also participates in the pathogenesis of many skin disorders, including aberrant wound healing, in many respects. This review focuses on the composition of the skin microbiome in cutaneous wounds of different types (i...
2024: Burns and Trauma
https://read.qxmd.com/read/38444628/carbon-dioxide-laser-for-precise-and-bloodless-contouring-of-soft-tissue-ahead-of-skin-grafting-a-case-example-of-technique-and-benefits
#23
Parisa Moori, Laura Cappuyns, Kayvan Shokrollahi
Scarring is a dynamic development as a result of the wound healing process. Post-burn scars are often hypertrophic in nature and thus exhibit a much thicker and firmer scar, often leading to contractures. Various strategies have been implemented by burns surgeons to endeavour to mitigate and improve such symptoms and appearances . Laser therapy in the control of hypertrophic scarring is of continual developing interest within this field. We demonstrate the advantageous, intra-operative use of a carbon dioxide laser for precise contouring of a burn scar prior to skin grafting in a 36 year-old female with hypertrophic scarring following a 65% total body surface area flash flame burn...
June 2024: JPRAS Open
https://read.qxmd.com/read/38444425/comprehensive-review-of-thermomechanical-fractional-injury-device-applications-in-medical-and-cosmetic-dermatology
#24
REVIEW
Blanca Estupiñan, Adam Souchik, Alexandra Kiszluk, Shraddha Desai
OBJECTIVE: Our aim was to review the current and emerging dermatological applications of the novel thermomechanical fractional injury (TMFI) device, Tixel® (Novoxel, Netanya, Israel). METHODS: A systematic review of PubMed using the search terms of "Tixel", "thermomechanical fractional", ["thermomechanical ablation" and "skin"], and ["thermomechanical ablation" and "dermatology"]. RESULTS: Thirty-six articles matched our inquiry. Fifteen articles did not meet inclusion criteria...
February 2024: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/38443457/quantification-of-myocardial-scar-of-different-etiology-using-dark-and-bright-blood-late-gadolinium-enhancement-cardiovascular-magnetic-resonance
#25
JOURNAL ARTICLE
Lamis Jada, Robert J Holtackers, Bibi Martens, Hedwig M J M Nies, Caroline M Van De Heyning, Rene M Botnar, Joachim E Wildberger, Tevfik F Ismail, Reza Razavi, Amedeo Chiribiri
Dark-blood late gadolinium enhancement (LGE) has been shown to improve the visualization and quantification of areas of ischemic scar compared to standard bright-blood LGE. Recently, the performance of various semi-automated quantification methods has been evaluated for the assessment of infarct size using both dark-blood LGE and conventional bright-blood LGE with histopathology as a reference standard. However, the impact of this sequence on different quantification strategies in vivo remains uncertain. In this study, various semi-automated scar quantification methods were evaluated for a range of different ischemic and non-ischemic pathologies encountered in clinical practice...
March 5, 2024: Scientific Reports
https://read.qxmd.com/read/38442406/3d-printing-of-alginate-chitosan-based-scaffold-empowered-by-tyrosol-loaded-niosome-for-wound-healing-applications-in-vitro-and-in-vivo-performances
#26
JOURNAL ARTICLE
Farzaneh Mahmoudi Beram, Saba Naeimaei Ali, Ghazal Mesbahian, Fatemeh Pashizeh, Mohammadhosein Keshvadi, Farzaneh Mashayekhi, Behnoosh Khodadadi, Zahra Bashiri, Alaa Moeinzadeh, Niloufar Rezaei, Saina Namazifard, Nikoo Hossein-Khannazer, Mohammad Tavakkoli Yaraki
This study introduces a tyrosol-loaded niosome integrated into a chitosan-alginate scaffold (Nio-Tyro@CS-AL), employing advanced electrospinning and 3D printing techniques for wound healing applications. The niosomes, measuring 185.40 ± 6.40 nm with a polydispersity index of 0.168 ± 0.012, encapsulated tyrosol with an efficiency of 77.54 ± 1.25%. The scaffold's microsized porous structure (600-900 μm) enhances water absorption, promoting cell adhesion, migration, and proliferation. Mechanical property assessments revealed the scaffold's enhanced resilience, with niosomes increasing the compressive strength, modulus, and strain to failure, indicative of its suitability for wound healing...
March 5, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38440721/comprehensive-treatment-of-a-rare-case-of-complete-primary-pachydermoperiostosis-with-large-facial-keloid-scars-a-case-report-and-literature-review
#27
Haibo Zhao, Jianglin Zhang, Renliang He, Linlin Bao
INTRODUCTION: Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy, is a rare autosomal dominant disease with primary clinical features of pachydermia (thickening of skin) and periostosis (new bone formation). Keloid scar formation is also rather obscure, and some scientists have claimed that keloid scars contain an excessive amount of fibroblasts compared with normal skin as well as a dense mass of irregularly deposited connective tissues. CASE PRESENTATION: A 25-year-old man exhibited extensive skin folding on his face, a gyrus-like scalp, depressed nasolabial folds, and keloids...
2024: Case Reports in Dermatology
https://read.qxmd.com/read/38439730/a-case-of-noonan-syndrome-and-kyrle-disease-casualty-or-causality
#28
JOURNAL ARTICLE
Marco Brusasco, Arlind Kalaja, Francesca Satolli, Claudio Feliciani, Maria Beatrice De Felici Del Giudice
A 39-year-old Caucasian woman affected by Noonan Syndrome (NS) mutated in RAF1 was referred to us with itchy lesions on her limbs that had appeared two months earlier. Clinically, there were multiple umbilicated papules with a hyperkeratotic central plug, localized on the upper and lower limbs (Figure 1, a-b). The patient had no personal history of diabetes mellitus or chronic renal failure, but suffered from hypertrophic cardiomyopathy. Blood tests showed no abnormalities. On histological examination of a skin lesion, an ectatic hair follicle with a hyperkeratotic ostium was observed with fragments of hair, inflammatory cells, and epidermal perforation...
December 2023: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/38438764/a-different-approach-for-protruding-earlobe-correction-modified-fish-tail-technique
#29
JOURNAL ARTICLE
Batuhan Sert, Meltem Ayhan Oral, Ozgur Turan, Ilker Uyar
BACKGROUND: Protruding ears are the most common auricular abnormalities seen in children (1). Protruding ears are a condition that has social and psychological consequences due to its physical appearance and one of the main causes of peer bullying at young ages (2). While various surgical methods exist to address prominent ears, the options for correcting the lobule are relatively scarce. In this study, we are aimed to present the modified fish-tail technique that we have developed and to compare it with other techniques in the literature...
March 4, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38436118/efficacy-and-safety-of-1064-nm-fractional-picosecond-laser-for-the-treatment-of-postmastectomy-scars-in-transgender-men-a-randomized-controlled-trial
#30
JOURNAL ARTICLE
Suthinee Rutnin, Tanat Yongpisarn, Nawara Sakpuwadol, Amornrut Namasondhi, Cherrin Pomsoong, Teerapong Rattananukrom, Kunlawat Thadanipon
OBJECTIVES: Subcutaneous mastectomy is a crucial component of gender affirmation therapy for transgender men (TM), but the scars that result from this procedure can frequently impair their quality of life. This study aimed to assess the efficacy and safety of 1064-nm fractional picosecond laser (FxPico) treatment for hypertrophic and atrophic postmastectomy scars in TM. METHODS: Twenty-two patients with a total of 35 pairs of bilateral symmetric mastectomy scars were enrolled...
March 4, 2024: Lasers in Surgery and Medicine
https://read.qxmd.com/read/38435816/fibroblasts-and-endothelial-cells-interplay-drives-hypertrophic-scar-formation-insights-from-in-vitro-and-in-vivo-models
#31
JOURNAL ARTICLE
Yaxin Tan, Mengde Zhang, Yi Kong, Fanliang Zhang, Yuzhen Wang, Yuyan Huang, Wei Song, Zhao Li, Linhao Hou, Liting Liang, Xu Guo, Qinghua Liu, Yu Feng, Chao Zhang, Xiaobing Fu, Sha Huang
Hypertrophic scar formation is influenced by the intricate interplay between fibroblasts and endothelial cells. In this study, we investigated this relationship using in vitro and in vivo models. Clinical observations revealed distinct morphological changes and increased vascularity at pathological scar sites. Further analysis using OCTA, immunohistochemistry, and immunofluorescence confirmed the involvement of angiogenesis in scar formation. Our indirect co-culture systems demonstrated that endothelial cells enhance the proliferation and migration of fibroblasts through the secretion of cytokines including VEGF, PDGF, bFGF, and TGF-β...
March 2024: Bioengineering & Translational Medicine
https://read.qxmd.com/read/38435463/a-retrospective-study-for-labia-minora-reduction-by-serrated-shaped-resection
#32
JOURNAL ARTICLE
Shou-Jie Wang, Kai Xu, Xiao-Ling Chen, Bang-Hui Shi, Hui Wang, Li-Hong Wu, Chun-Ye Chen
BACKGROUND: The demand for genital plastic surgery has increased dramatically among female patients globally. Although various labia minora reduction procedures have been applied with different indications, advantages, and disadvantages, none has been universally accepted as the best method. So, we presented an innovative strategy for this increasingly demanded reconstructive procedure. METHODS: In this retrospective study, we included 29 patients seen between November 2020 and May 2023 with hypertrophic labia minora...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38424728/photo-crosslinkable-polyester-microneedles-as-sustained-drug-release-systems-toward-hypertrophic-scar-treatment
#33
JOURNAL ARTICLE
Anna Szabó, Ignace De Decker, Sam Semey, Karel E Y Claes, Phillip Blondeel, Stan Monstrey, Jo Van Dorpe, Sandra Van Vlierberghe
Burn injuries can result in a significant inflammatory response, often leading to hypertrophic scarring (HTS). Local drug therapies e.g. corticoid injections are advised to treat HTS, although they are invasive, operator-dependent, extremely painful and do not permit extended drug release. Polymer-based microneedle (MN) arrays can offer a viable alternative to standard care, while allowing for direct, painless dermal drug delivery with tailorable drug release profile. In the current study, we synthesized photo-crosslinkable, acrylate-endcapped urethane-based poly( ε -caprolactone) (AUP-PCL) toward the fabrication of MNs...
December 2024: Drug Delivery
https://read.qxmd.com/read/38423396/the-role-of-positional-information-in-determining-dermal-fibroblast-diversity
#34
REVIEW
Pratyusha Chitturi, Andrew Leask
The largest mammalian organ, skin, consisting of a dermal connective tissue layer that underlies and supports the epidermis, acts as a protective barrier that excludes external pathogens and disseminates sensory signals emanating from the local microenvironment. Dermal connective tissue is comprised of a collagen-rich extracellular matrix (ECM) that is produced by connective tissue fibroblasts resident within the dermis. When wounded, a tissue repair program is induced whereby fibroblasts, in response to alterations in the microenvironment, produce new ECM components, resulting in the formation of a scar...
February 27, 2024: Matrix Biology: Journal of the International Society for Matrix Biology
https://read.qxmd.com/read/38420076/comparing-complications-and-patient-satisfaction-following-injectable-collagenase-versus-limited-fasciectomy-for-dupuytren-s-disease-a-systematic-review-and-meta-analysis
#35
REVIEW
Zainah A Alhebshi, Aya O Bamuqabel, Zainab Alqurain, Dana Dahlan, Hanan I Wasaya, Ziyad S Al Saedi, Gutaybah S Alqarni, Danah Alqarni, Bayan Ghalimah
Dupuytren's disease (DD) is a fibroproliferative disorder that manifests as an abnormal growth of myofibroblasts, causing nodule formation and contractures and affecting digit function. If left untreated, these contractures can lead to a loss of mobility and potentially impact hand function. This systematic review critically compares and evaluates the existing literature on the complications and patient satisfaction following injectable collagenase Clostridium histolyticum (CCH) versus limited fasciectomy (LF) for DD...
January 2024: Curēus
https://read.qxmd.com/read/38418830/effects-of-mir-214-on-adenosine-a2a-receptor-and-carboxymethyl-chitosan-nanoparticles-on-the-function-of-keloid-fibroblasts-and-their-mechanisms
#36
JOURNAL ARTICLE
Yong Du, Jing Liu, Qing Hao, Shun Wang, Aijun Zhang, Yongzhong Li, Ninghan Feng
This work prepared and investigated the impact of carboxymethyl chitosan nanoparticles (MC-NPs) on the proliferative capability of keloid fibroblasts (KFBs) while analyzing the mechanistic roles of miR-214 and adenosine A2A receptor (A2AR) in fibroblasts within hypertrophic scars. MC-NPs were synthesized through ion cross-linking, were characterized using transmission electron microscopy (TEM) and laser particle size scattering. The influence of MC-NPs on the proliferation capacity of KFBs was assessed using the MTT method...
February 28, 2024: Scientific Reports
https://read.qxmd.com/read/38411191/medial-epicanthal-fold-correction-using-a-y-w-epicanthoplasty-in-asian-eyelids
#37
JOURNAL ARTICLE
Hojin Park, Yijun Moon, Da Som Kim, Seung Ha Park
Many surgical techniques for managing epicanthal folds have been reported, but their main drawbacks include a noticeable scar in Asians, acute medial canthal angle, and applicability only in mild or moderate epicanthal folds. This study described a novel surgical technique, Y-W epicanthoplasty, and assessed the medial canthal shape and scarring in patients who underwent Y-W epicanthoplasty. Patients with moderate or severe epicanthal folds between January 2004 and February 2017 were included in this study. Pre- and postoperative intercanthal distance (ICD), inner canthal angle (ICA), and interpupillary distance (IPD) were measured...
February 27, 2024: Journal of Craniofacial Surgery
https://read.qxmd.com/read/38409959/amniotic-membrane-dressings-for-treatment-of-aplasia-cutis-in-newborns
#38
JOURNAL ARTICLE
Maliheh Kadivar, Razieh Sangsari, Somayeh Rostamli, Soheila Sotoudeh, Kayvan Mirnia
BACKGROUND: Aplasia cutis congenita (ACC) is a rare congenital skin defect characterized by a focal or extensive absence of the epidermis, dermis, and occasionally, subcutaneous tissue. When the wound caused by this defect is wide or deep, various treatments are used, including skin grafting. The amniotic membrane (AM) is a biological dressing that facilitates re-epithelialization as it contains mesenchymal cells and numerous growth factors. OBJECTIVE: To report the efficacy of AM dressings in treating the skin defects of ACC...
February 26, 2024: Pediatric Dermatology
https://read.qxmd.com/read/38396801/differential-photosensitivity-of-fibroblasts-obtained-from-normal-skin-and-hypertrophic-scar-tissues
#39
JOURNAL ARTICLE
Junya Kusumoto, Masaya Akashi, Hiroto Terashi, Shunsuke Sakakibara
It is unclear whether normal human skin tissue or abnormal scarring are photoreceptive. Therefore, this study investigated photosensitivity in normal skin tissue and hypertrophic scars. The expression of opsins, which are photoreceptor proteins, in normal dermal fibroblasts (NDFs) and hypertrophic scar fibroblasts (HSFs) was examined. After exposure to blue light (BL), changes in the expression levels of αSMA and clock-related genes, specifically PER2 and BMAL1 , were examined in both fibroblast types...
February 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38388742/early-intervention-of-carbon-dioxide-fractional-laser-in-hypertrophic-scar-through-tgf%C3%AE-1-smad3-signaling-pathway
#40
JOURNAL ARTICLE
Zizheng Yang, Zhiguo Yang, Zongbao Zuo
Hypertrophic scars are usually the result of surgical trauma or burn,and more common in individuals with a darker skin color. They appear as red and raised lesions around the wound that continually expand over a period of weeks or months, causing itching, pain, burning sensation and discomfort. Severe scarring affects interpersonal and social relationships, and decreases the quality of life of the patients.The aim of this study was to evaluate the effect of carbon dioxide fractional laser as an early intervention against hypertrophic scars using a rabbit ear scar model, and explore the role of the TGFβ-1/ Smad3 signaling pathway in scar hyperplasia...
February 23, 2024: Lasers in Medical Science
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