Farzaneh Mahmoudi Beram, Saba Naeimaei Ali, Ghazal Mesbahian, Fatemeh Pashizeh, Mohammadhosein Keshvadi, Farzaneh Mashayekhi, Behnoosh Khodadadi, Zahra Bashiri, Alaa Moeinzadeh, Niloufar Rezaei, Saina Namazifard, Nikoo Hossein-Khannazer, Mohammad Tavakkoli Yaraki
This study introduces a tyrosol-loaded niosome integrated into a chitosan-alginate scaffold (Nio-Tyro@CS-AL), employing advanced electrospinning and 3D printing techniques for wound healing applications. The niosomes, measuring 185.40 ± 6.40 nm with a polydispersity index of 0.168 ± 0.012, encapsulated tyrosol with an efficiency of 77.54 ± 1.25%. The scaffold's microsized porous structure (600-900 μm) enhances water absorption, promoting cell adhesion, migration, and proliferation. Mechanical property assessments revealed the scaffold's enhanced resilience, with niosomes increasing the compressive strength, modulus, and strain to failure, indicative of its suitability for wound healing...
March 5, 2024: ACS Applied Bio Materials