keyword
MENU ▼
Read by QxMD icon Read
search

Hypertrophic scar

keyword
https://www.readbyqxmd.com/read/28319503/myocardial-infarction-in-a-patient-with-hypertrophic-cardiomyopathy-but-normal-coronary-arteries
#1
Shuheng Li, Xiaoxin Sun, Zongyao Zhang, Zuo-Xiang He
A 57-year-old man with a history of hypertrophic cardiomyopathy diagnosed by echocardiography experienced atypical chest pain and dyspnea for 6 months. A rest Tc-MIBI myocardial SPECT imaging and a F-FDG myocardial PET/CT imaging were performed, which showed multiple matched myocardial perfusion/metabolism defects in the left ventricle, indicating scar tissue. Surprisingly, subsequent contrast coronary angiography revealed no significant coronary artery stenosis.
March 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28316163/-effects-of-silencing-smad-ubiquitination-regulatory-factor-2-on-the-function-of-human-hypertrophic-scar-derived-fibroblasts
#2
Z Zhang, F Kuang, C L Liu, B Chen, W B Tang, X J Li
Objective: To explore the effects of silencing Smad ubiquitination regulatory factor 2 (Smurf2) on the secretion of transforming growth factor beta 1 (TGF-β(1)), alpha-smooth muscle actin (α-SMA), and collagen type Ⅰ by human hypertrophic scar-derived fibroblasts. Methods: The human normal skin-derived fibroblasts and hypertrophic scar-derived fibroblasts were cultured with explant culture technique from the normal skin and hypertrophic scar tissue, which was obtained from 9 patients with hypertrophic scars after burn...
March 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28293527/the-use-of-silgel-stc-se-a-topical-silicone-gel-for-the-treatment-and-reduction-of-hypertrophic-and-keloid-scars
#3
Sharon A Stewart, Greig M G Dougall, Erica M Tafuro
BACKGROUND: A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars. METHODS: A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). The efficacy of Silgel STC-SE on the scar was evaluated by skin hydration, skin moisture evaporation, skin elasticity, basic scar measurements, subjective patient questionnaire data, and image analysis...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28289991/quantitative-analysis-of-late-gadolinium-enhancement-in-hypertrophic-cardiomyopathy-comparison-of-diagnostic-performance-in-myocardial-fibrosis-between-gadobutrol-and-gadopentetate-dimeglumine
#4
Dongting Liu, Xiaohai Ma, Jiayi Liu, Lei Zhao, Hui Chen, Lei Xu, Zhonghua Sun, Zhanming Fan
The purpose of this study was to compare different semi-automated late gadolinium enhancement (LGE) quantification techniques using gadobutrol and gadopentetate dimeglumine contrast agents with regard to the diagnosis of fibrotic myocardium in patients with hypertrophic cardiomyopathy (HCM). Thirty patients with HCM underwent two cardiac MRI protocols with use of gadobutrol and gadopentetate dimeglumine. Contrast-to-noise ratio (CNR) between LGE area and remote myocardium (CNRremote), between LGE area and left ventricular blood pool (CNRpool), and signal-to-noise ratio (SNR) in LGE were compared...
March 13, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28289499/hypertrophic-cardiomyopathy-with-unusual-extensive-scarring-pattern-danon-disease
#5
Dan D Le, Paulino Alvarez, Roberto Barrios, Michael Arriaga, Mariyam Cherry, Dipan Shah, C Huie Lin
No abstract text is available yet for this article.
October 2016: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28288846/pleiotropic-fty720-is-a-specific-and-potent-therapy-for-hypertrophic-scars
#6
Fen Shi, Xiaoling Cao, Zhicheng Hu, Da Ma, Dong Guo, Jian Zhang, Changlin Zhang, Peng Liu, Shanqiang Qu, Jiayuan Zhu, Wuguo Deng, Bing Tang
Hypertrophic scars (HS) is a fibrotic skin condition characterized by aberrant fibroblast phenotypes and excessive deposition of extracellular matrix components. 2-Amino-2-[2-(4-octylphenyl)]-1, 3-propanediol hydrochloride (FTY720), an immunomodulator approved for treating multiple sclerosis, is reported to attenuate fibrosis in multiple disease models. Here we found that FTY720 could significantly attenuate the proliferation and fibrosis in HS fibroblasts (HSFs) as well as in animal HS model. Upon treating HSFs or normal dermal fibroblasts (NFs) with FTY720 at different concentrations for different time periods, we found that FTY720 presented a pleiotropic effect specifically on HSFs, but not NFs, including reducing cell viability, arresting cell cycle progression at G0/G1 phase, promoting apoptosis, inhibiting migration and contraction, and suppressing the expressions of α-smooth muscle actin (α-SMA), collagen I, and collagen III...
March 10, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28288835/anti-proliferative-and-anti-migratory-effects-of-hyperforin-in-2d-and-3d-artificial-constructs-of-human-dermal-fibroblasts-a-new-option-for-hypertrophic-scar-treatment
#7
J Füller, C C Müller-Goymann
No abstract text is available yet for this article.
March 10, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28287424/keloid-and-hypertrophic-scars-are-the-result-of-chronic-inflammation-in-the-reticular-dermis
#8
REVIEW
Rei Ogawa
Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. The latter is characterized by continuous and histologically localized inflammation...
March 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28283308/percutaneous-collagen-induction-as-an-additive-treatment-for-scar-formation-following-thermal-injuries-preliminary-experience-in-47-children
#9
Rainer Kubiak, Bettina Lange
BACKGROUND: Thermal injuries are one of the most physically and psychologically devastating causes of pediatric trauma. Post-traumatic sequelae such as hypertrophic scars and contractures often result in long lasting morbidity and disfigurement. Conservative therapy, including pressure garments and silicone, is the gold standard for scar management in the pediatric population. Most recently percutaneous collagen induction (PCI) was introduced as an alternative treatment in adults. The aim of this report was to share our experience with PCI in children and adolescents in scar management following thermal injuries...
March 7, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28280895/epicanthoplasty-with-epicanthal-dermatic-tension-releasing-incision-based-on-skin-projection-of-inner-canthal-ligament
#10
Linghuan Zeng, Ying Cen, Junjie Chen, Lei Lei
BACKGROUND: Epicanthoplasty is a reconstructive procedure that eliminates the deformity of the epicanthal fold and provides a more esthetic inner canthus. The epicanthal tension-releasing incision is a core technique of epicanthoplasty. However, which epicanthal dermatic tension-releasing incision most effectively provides epicanthal tension release remains unclear. We designed a novel dermatic tension-releasing incision based on the skin projection of the inner canthal ligament and compared it with the more conventional incision parallel to the lower inner canthal mucocutaneous junction (white line)...
March 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28275532/surgical-correction-of-the-webbed-neck-an-alternative-lateral-approach
#11
Imen Mehri Turki
Objective: The webbed neck deformity or pterygium colli is the number one symptom of the Turner syndrome that leads the patient to consult a doctor. Various but rare surgical approaches have been described to correct this deformity. We reviewed our experience with the surgical correction of the pterygium colli. Methods: Through five clinical cases, we describe the surgical technique with a lateral approach which provides a better control of the operative site, allows for the excision of the underlying trapezial fascial web, thus preventing recurrence seen in the posterior approach, and restores a normal hairline...
2017: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW
https://www.readbyqxmd.com/read/28267391/medial-canthal-defects-following-tumour-excision-to-reconstruct-or-not-to-reconstruct
#12
Fariha Shafi, Deepa Rathore, Andria Johnson, Purnima Mehta, Harpreet S Ahluwalia
Laissez-faire following excision of peri-ocular tumours has been described, but is not universally well established. We describe our experience with laissez-faire for managing medial canthal defects following tumour excision and compare our outcomes with full thickness skin grafts. Retrospective comparative case series of 68 patients who underwent reconstruction of a medial canthal defect using laissez-faire with sutured Sorbsan (LFS) (n = 36) or a full thickness skin graft (FTSG) (n = 32) at the same centre...
March 7, 2017: Orbit
https://www.readbyqxmd.com/read/28259957/photodynamic-inactivation-of-fibroblasts-and-inhibition-of-staphylococcus%C3%A2-epidermidis-adhesion-and-biofilm-formation-by-toluidine-blue-o
#13
Xin Li, Zizhong Liu, Houfang Liu, Xi Chen, Yue Liu, Honglue Tan
Treating skin and soft tissue infections of severe limb traumas can be challenging. Crucial concerns focus on inhibiting biofilm formation by antibiotic‑resistant bacteria, and preventing scar formation by fibroblastic hyperproliferation. The local use of toluidine blue O (TBO)‑mediated photodynamic therapy (PDT) may be a promising strategy for treating such lesions. The present study used Staphylococcus epidermidis (strain ATCC 35984) to assess the effects of TBO‑PDT on bacterial adherence and biofilm formation, using confocal laser scanning microscopy (CLSM), tissue culture plating (TCP) and scanning electron microscopy (SEM)...
February 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28259900/microrna%C3%A2-185-regulates-transforming-growth-factor%C3%A2-%C3%AE-1-and-collagen%C3%A2-1-in-hypertrophic-scar-fibroblasts
#14
Kaiyan Xiao, Xusong Luo, Xiuxia Wang, Zhen Gao
Transforming growth factor-β1 (TGF-β1) and collagen type I (Col-1) serve a critical role in the development and progression of hypertrophic scarring (HS). The present study hypothesized that a post‑translational mechanism of microRNAs (miR) regulated the expression of TGF‑β1 and Col‑1 in HS fibroblasts (HSFBs). A collection of 20 HS tissues was compared with corresponding normal tissues from clinical patients, and the expression of miR‑185 was measured. Using PicTar, TargetScan and miRBase databases, it was identified that miR‑185 may be a regulator of TGF‑β1 and Col‑1 in humans...
February 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28252545/reduction-of-the-areolar-diameter-after-ultrasound-assisted-liposuction-for-gynecomastia
#15
Mustafa Keskin, Mustafa Sutcu, Mustafa Hanci, Bulent Cigsar
BACKGROUND: One of the clinical aspects characterizing gynecomastia is the enlargement of the nipple-areolar complex (NAC) due to hypertrophic breast glands, and the excessive fatty tissue underneath. OBJECTIVE: The purpose of this study was to quantify the reduction of the areolar diameter after ultrasound-assisted liposuction (UAL) of the male breast. METHODS: The horizontal diameters of the NACs of 30 men who underwent UAL were measured before surgery, 1 month after surgery and 6 months after surgery in a standard fashion...
March 1, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28244902/vibration-anesthesia-for-pain-reduction-during-intralesional-steroid-injection-for-keloid-treatment
#16
Kui Young Park, Yohan Lee, Ji Yeon Hong, Won Soon Chung, Myeung Nam Kim, Beom Joon Kim
BACKGROUND: Patients suffer significant pain during intralesional steroid injection treatment for keloids and hypertrophic scars. Vibration anesthesia has been shown to effectively and safely alleviate pain sensations, likely by reducing pain transmission from peripheral receptors to the brain. OBJECTIVE: The objective was to evaluate the efficacy, safety, and patient satisfaction associated with vibration anesthesia for reducing pain during intralesional corticosteroid injection...
February 27, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28244587/scar-outcomes-in-dermatological-surgery
#17
Burcu Kim, Melissa Sgarioto, Daniel Hewitt, Robert Paver, Julia Norman, Pablo Fernandez-Penas
BACKGROUND/OBJECTIVES: Significant functional impairment and psychological burden may result from poor scar quality and its impact on patient's quality of life has been well-established. It is important to identify measures to reduce the risk of surgical complications. METHOD: 212 patients undergoing dermatological surgery were recruited from March 2011 to February 2014. Their age, sex, surgical site, closure type, defect size (length and width), scar length, number of deep sutures, suture type and size were recorded...
February 28, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28236563/a-clinical-trial-of-tension-and-compression-orthoses-for-dupuytren-contractures
#18
Annelien Brauns, Maarten Van Nuffel, Luc De Smet, Ilse Degreef
STUDY DESIGN: Randomized clinical trial on 2 patient groups with Dupuytren's disease. INTRODUCTION: Despite an unpredictable outcome, surgery remains an important treatment for Dupuytren's disease. Orthotic devices are a controversial noninvasive treatment method to influence the myofibroblasts in the nodules. PURPOSE OF THE STUDY: To detect how much improvement 2 types of orthotic device (tension and compression) as only treatment intervention can provide on a Dupuytren's contracture...
February 21, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28230602/subcutaneous-c-shape-muscular-flap-for-correcting-the-depression-of-alar-base-in-affected-side-in-patients-with-unilateral-complete-cleft-lip-palate-during-primary-surgery
#19
Dandan Wu, Guomin Wang, Ningjuan Ouyang, Yuhen Lin, Yang Chen, Jiewen Dai
PURPOSE: The depression of alar base in affected side in patients with unilateral complete cleft lip/palate (CL/P) is one of common clinical features. In this study, the authors try to explore the effect of subcutaneous C shape muscular flap for correcting the depression of alar base in affected side in patients with unilateral complete CL/P during primary surgery. METHODS: A total of 30 patients with unilateral complete CL/P who received primary correction of the lip nose deformity were included in this study...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28226374/adjuncts-to-improve-nasal-reconstruction-results
#20
Shayna Lee Gordon, Eva A Hurst
The final cosmetic appearance of nasal reconstruction scars is of paramount importance to both the patient and surgeon. Ideal postreconstruction nasal scars are flat and indistinguishable from surrounding skin. Unfortunately, even with meticulous surgical execution, nasal scars can occasionally be suboptimal. Abnormal fibroblast response can lead to hypertrophic nasal scars, and excessive angiogenesis may lead to telangiectasias or an erythematous scar. Imperfect surgical closure or poor postoperative management can lead to surgical outcomes with step-offs, depressions, suture marks, or dyspigmentation...
February 2017: Facial Plastic Surgery: FPS
keyword
keyword
106245
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"