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Hypertrophic scar

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https://www.readbyqxmd.com/read/29330036/regulation-of-fibrotic-changes-by-the-synergistic-effects-of-cytokines-dimensionality-and-matrix-towards-the-development-of-an-in-vitro-human-dermal-hypertrophic-scar-model
#1
Shikha Chawla, Sourabh Ghosh
Current therapeutic strategies to reduce scarring in full thickness skin defect offer limited success due to poor understanding of scar tissue formation and the underlying signaling pathways. There is an urgent need to develop human cell based in vitro scar tissue models as animal testing is associated with ethical and logistic complications and inter-species variations. Pro-inflammatory cytokines play critical role in regulating scar development through complex interplay and interaction with the ECM and corresponding signaling pathways...
January 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29322537/comparative-evaluations-of-hypertrophic-scar-formation-in-in-vivo-models
#2
Myeongjin Kim, Hyejin Kim, Hyun Wook Kang
BACKGROUND AND OBJECTIVE: Hypertrophic scar (HTS) results from a connective tissue reaction to trauma, inflammation, surgery, or burn on skin. In spite of various techniques for wound generation, the degree of scar in animal models after healing is still unpredictable and less reproducible. The objective of the current study was to identify the appropriate method to create the maximal HTS tissue in a reliable manner by comparing three different methods in vivo. MATERIALS AND METHODS: A 27 ICR mice were tested for the in vivo evaluations...
January 11, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29316036/inhibition-of-ire1-results-in-decreased-scar-formation
#3
Tatiana V Boyko, Rakesh Bam, Dadi Jiang, Zhen Wang, Namrata Bhatia, Misha C Tran, Michael T Longaker, Albert C Koong, George P Yang
Wound healing is characterized by the production of large amounts of protein necessary to replace lost cellular mass and extracellular matrix. The unfolded protein response (UPR) is an important adaptive cellular response to increased protein synthesis. One of the main components of the UPR is IRE1, an ER transmembrane protein with endonuclease activity that produces the activated form of the transcription factor XBP1. Using luciferase reporter mice for Xbp1 splicing, we showed that IRE1 was up-regulated during excisional wound healing at the time in wound healing consistent with that of the proliferative phase, when the majority of protein synthesis for cellular proliferation and matrix deposition occurs...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29301325/extracorporeal-shock-wave-therapy-alters-the-expression-of-fibrosis-related-molecules-in-fibroblast-derived-from-human-hypertrophic-scar
#4
Hui Song Cui, A Ram Hong, June-Bum Kim, Joo Hyang Yu, Yoon Soo Cho, So Young Joo, Cheong Hoon Seo
Extracorporeal shock wave therapy (ESWT) considerably improves the appearance and symptoms of post-burn hypertrophic scars (HTS). However, the mechanism underlying the observed beneficial effects is not well understood. The objective of this study was to elucidate the mechanism underlying changes in cellular and molecular biology that is induced by ESWT of fibroblasts derived from scar tissue (HTSFs). We cultured primary dermal fibroblasts derived from human HTS and exposed these cells to 1000 impulses of 0...
January 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29282183/techniques-for-optimizing-surgical-scars-part-2-hypertrophic-scars-and-keloids
#5
Kathryn Potter, Sailesh Konda, Vicky Zhen Ren, Apphia Lihan Wang, Aditya Srinivasan, Suneel Chilukuri
Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 2 focuses on scar revision for hypertrophic and keloids scars. Scar revision options for hypertrophic and keloid scars include corticosteroids, bleomycin, fluorouracil, verapamil, avotermin, hydrogel scaffold, nonablative fractional lasers, ablative and fractional ablative lasers, pulsed dye laser (PDL), flurandrenolide tape, imiquimod, onion extract, silicone, and scar massage...
2017: Skinmed
https://www.readbyqxmd.com/read/29282083/tissue-transglutaminase-in-astrocytes-is-enhanced-by-inflammatory-mediators-and-is-involved-in-the-formation-of-fibronectin-fibril-like-structures
#6
Nathaly Espitia Pinzón, John J P Brevé, John G J M Bol, Benjamin Drukarch, Wia Baron, Anne-Marie van Dam
BACKGROUND: During multiple sclerosis (MS) lesion formation, inflammatory mediators are produced by microglial cells and invading leukocytes. Subsequently, hypertrophic astrocytes fill the lesion and produce extracellular matrix (ECM) proteins that together form the astroglial scar. This is beneficial because it seals off the site of central nervous system (CNS) damage. However, astroglial scarring also forms an obstacle that inhibits remyelination of brain lesions. This is possibly an important cause for incomplete remyelination of the CNS in early stage MS patients and for failure of remyelination when the disease progresses...
December 28, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29279953/chemical-peeling-with-a-modified-phenol-formula-for-the-treatment-of-facial-freckles-on-asian-skin
#7
Hua-Feng Sun, Hai-Shan Lu, Le-Qi Sun, Wei-Dong Ping, Dong-Sheng Mao, Dan Li
BACKGROUND: Chemical peeling is an efficient method for the treatment of pigment disorders. For freckles, medium-depth to deep peeling using a phenol solution is one of the most effective chemical peels, and modifications of facial skin can be observed up to 20 years after peeling. However, applying phenol to the skin may cause serious side effects. Phenol peeling has been rarely used in Asia due to its tendency to cause permanent pigmentary changes and hypertrophic scars. METHODS: In total, 896 Chinese inpatients with facial freckles were enrolled in this study...
December 26, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29249978/prediction-of-scar-size-in-rats-six-months-after-burns-based-on-early-post-injury-polarization-sensitive-optical-frequency-domain-imaging
#8
Eli Kravez, Martin Villiger, Brett Bouma, Martin Yarmush, Zohar Yakhini, Alexander Golberg
Hypertrophic scars remain a major clinical problem in the rehabilitation of burn survivors and lead to physical, aesthetic, functional, psychological, and social stresses. Prediction of healing outcome and scar formation is critical for deciding on the best treatment plan. Both subjective and objective scales have been devised to assess scar severity. Whereas scales of the first type preclude cross-comparison between observers, those of the second type are based on imaging modalities that either lack the ability to image individual layers of the scar or only provide very limited fields of view...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29247692/granzyme-b-in-skin-inflammation-and-disease
#9
REVIEW
Christopher T Turner, Darielle Lim, David J Granville
Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. Found at low levels in healthy skin, GzmB is dramatically elevated in chronic disease and inflammatory skin disorders, including diabetic ulcers, hypertrophic scarring, autoimmune skin disorders, cutaneous leishmaniasis and aging skin. Traditionally known for its pro-apoptotic function, the role of GzmB in disease has been redefined due to the discovery of additional activities involving the cleavage of extracellular matrix proteins, epithelial barrier disruption, fibrosis, vascular permeability, anoikis, inflammation and autoimmunity...
December 13, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29247361/biocompatible-5-aminolevulinic-acid-au-nanoparticle-loaded-ethosomal-vesicles-for-in-vitro-transdermal-synergistic-photodynamic-photothermal-therapy-of-hypertrophic-scars
#10
Zheng Zhang, Yunsheng Chen, Jiayue Ding, Chunlei Zhang, Amin Zhang, Dannong He, Yixin Zhang
Biocompatible 5-aminolevulinic acid/Au nanoparticle-loaded ethosomal vesicle (A/A-ES) is prepared via ultrasonication for synergistic transdermal photodynamic/photothermal therapy (PDT/PTT) of hypertrophic scar (HS). Utilizing ultrasonication, Au nanoparticles (AuNPs) are synthesized and simultaneously loaded in ethosomal vesicles (ES) without any toxic agents, and 5-aminolevulinic acid (ALA) is also loaded in ES with 20% of the entrapment efficiency (EE). The prepared A/A-ES displays strong absorbance in 600-650 nm due to the plasmonic coupling effect between neighboring AuNPs in the same A/A-ES, which can simultaneously stimulate A/A-ES to produce heat and enhance quantum yields of reactive oxygen species (ROS) by using 632 nm laser...
December 15, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29244193/comparative-peptidomic-profile-between-human-hypertrophic-scar-tissue-and-matched-normal-skin-for-identification-of-endogenous-peptides-involved-in-scar-pathology
#11
Jingyun Li, Ling Chen, Qian Li, Jing Cao, Yanli Gao, Jun Li
Endogenous peptides recently attract increasing attention for their participation in various biological processes. Their roles in the pathogenesis of human hypertrophic scar remains poorly understood. In this study, we used liquid chromatography-tandem mass spectrometry to construct a comparative peptidomic profiling between human hypertrophic scar tissue and matched normal skin. A total of 179 peptides were significantly differentially expressed in human hypertrophic scar tissue, with 95 upregulated and 84 downregulated peptides between hypertrophic scar tissue and matched normal skin...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29240593/insights-into-the-pathophysiology-of-hypertrophic-scars-and-keloids-how-do-they-differ
#12
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29240586/insights-into-the-pathophysiology-of-hypertrophic-scars-and-keloids-how-do-they-differ
#13
Feras M Ghazawi, Ramin Zargham, Mirko S Gilardino, Denis Sasseville, Fatemeh Jafarian
GENERAL PURPOSE: To provide information about the clinical presentation of hypertrophic scars and keloids based on their varied structural components. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that manifest when the cicatrix fails to properly heal...
January 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29229135/intraoperative-factors-associated-with-postoperative-complications-in-body-contouring-surgery
#14
Barak Cohen, Benjamin Meilik, Ahuva Weiss-Meilik, Aviv Tarrab, Idit Matot
BACKGROUND: Several preoperative factors have been shown to influence outcome of body contouring surgeries. The effect of intraoperative features, including fluid volume administered, hemodynamic and respiratory parameters, and body temperature on postoperative complication, has not been reported to date. MATERIALS AND METHODS: All subsequent patients undergoing body contouring surgery in the Tel Aviv Medical Center between 2007 and 2012 were enrolled. Demographic and intraoperative data were collected and analyzed for possible associations with postoperative complications, including formation of seroma, hematoma/bleeding, other surgical site complications (infection, adhesiolysis, or need for debridement), formation of a hypertrophic scar, any documented, infection or a composite outcome of any of the previously mentioned...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29224036/laser-advances-in-the-treatment-of-burn-and-traumatic-scars
#15
Shilpi Khetarpal, Urvashi Kaw, Jeffrey S Dover, Kenneth A Arndt
The realm of scar management is constantly changing. Many factors need to be considered when developing a comprehensive treatment plan, including the nature of the scar and the patient. Scar characteristics can be divided by color, scar type and thickness, and body location. Topical and intralesional agents and light- and laserbased treatments can be used to revitalize and restore damaged skin in atrophic and hypertrophic scars. The most commonly used lasers are the pulsed-dye laser (PDL) and fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29218286/experience-of-breast-augmentation-in-pakistani-females
#16
Muhammad Ahmad
BACKGROUND: Breast augmentation is an elective surgery used to increase the size of the breast in females. This study was undertaken to determine the breast augmentation in Pakistani females. METHODS: From 2006 to 2011, 43 female patients who underwent breast augmentation via infra-mammary, periareolar, trans-umbilical and fat transfer were enrolled. For augmentation, saline-filled or gel-filled implants were used in the supine position under general anesthesia and local infiltration of adrenaline (1:100,000 dilution) on each side...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29212187/autophagy-protein-lc3-regulates-the-fibrosis-of-hypertrophic-scar-by-controlling-bcl-xl-in-dermal-fibroblasts
#17
Jihong Shi, Shan Shi, Bin Wu, Jian Zhang, Yan Li, Xue Wu, Julei Zhang, Kejia Wang, Bin Zhao, Weixia Cai, Xiaozhi Bai, Dahai Hu, Hao Guan
Hypertrophic scar (HS) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ECM) component deposition. Autophagy is a tightly regulated physiological process essential for cellular maintenance, differentiation, development and homeostasis. However, during the formation of HS, whether and how autophagy is regulated in dermal fibroblasts are still far from elucidated. Here we detected the autophagic capacity in HS and normal skin (NS) counterparts, explored and verified the key regulatory molecules of autophagy in HS-derived fibroblasts (HSFs), and validated the data using rabbit ear scar model...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29194788/a-cross-sectional-study-of-clinical-factors-associated-with-acne-facial-scarring-in-patients-with-active-acne
#18
Clio Dessinioti, Chrisa Zisimou, Effie Platsidaki, Andreas Katsambas, Christina Antoniou
Scarring may occur in 45% to 55% of acne patients, it may produce significant psychopathology, and it is challenging to treat.1,2,3 Identifying factors associated with acne scars may assist in their prevention strategy. We conducted a cross-sectional study to investigate clinical factors associated with acne facial scarring at first visit, including age, sex, smoking, family history of acne, and the history of previous acne treatments. Active acne on the face was graded by the Global Evaluation of Acne (GEA) scale (0-5), as previously described...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29186943/modified-minimally-invasive-direct-anterior-approach-through-a-bikini-incision-for-total-hip-arthroplasty-technique-and-results-in-young-female-patients
#19
C Faldini, A Mazzotti, F Perna, N Stefanini, A Panciera, F Pilla, A Ruffilli, E M Neonakis, F Traina
Direct anterior approach for THA has gained popularity over the last years. However, concerns have been raised regarding the cosmetic, related to the incision that does not respect the Langer’s skin tension line and may produce hypertrophic scars. The aim of this study was to analyze the preliminary results in 22 young female patients undergoing THA through a minimally invasive direct anterior approach using a modified oblique bikini incision. Clinical evaluations showed an improvement of WOMAC, UCLA and Harris Hip Score at 5-month follow-up...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29177979/photobiomodulation-effect-on-children-s-scars
#20
Jehan Alsharnoubi, Omnia Mohamed
The management of burn scars has become one of the major clinical challenges in the developing countries which involve enormous treatment cost; this needs new methods for better cost benefit relationship. The objective of the study is to analyze the effectiveness of low-level laser therapy on post-burn scar tissue in children. A randomized controlled study included 15 children, ranging from 2 to 10 years of age, presenting with burn scars. They received diode laser and topical treatment. Each scar was divided into two halves...
November 24, 2017: Lasers in Medical Science
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