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Hypertrophic scar

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https://www.readbyqxmd.com/read/28748418/left-ventricular-function-in-patients-with-hypertrophic-cardiomyopathy-and-its-relation-to-myocardial-fibrosis-and-exercise-tolerance
#1
Dimitrios Maragiannis, Paulino A Alvarez, Mohamad G Ghosn, Karen Chin, Jeremy J Hinojosa, John M Buergler, Dipan J Shah, Sherif F Nagueh
We sought to determine the relation between myocardial extracellular volume (ECV), left ventricular (LV) diastolic function, and exercise tolerance in patients with hypertrophic cardiomyopathy (HCM). Forty five HCM patients with an ejection fraction >50% and no previous septal reduction therapy underwent imaging by CMR and transthoracic echocardiography. CMR was used to quantify LV volumes, mass, EF, LA volumes, scar burden, pre and post contrast T1 relaxation times and ECV. Echocardiography was used to measure outflow tract gradients, mitral inflow and annular velocities, circumferential strain, systolic, early and late diastolic strain rates...
July 26, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28741153/recovery-of-acl-function-after-dynamic-intraligamentary-stabilization-is-resultant-to-restoration-of-acl-integrity-and-scar-tissue-formation
#2
Atesch Ateschrang, Sufian S Ahmad, Ulrich Stöckle, Steffen Schroeter, Willem Schenk, Marc Daniel Ahrend
PURPOSE: Dynamic intraligamentary stabilization (DIS) is recognized as a ligament preserving technique for the treatment of acute anterior cruciate ligament (ACL) injuries. The aim of this study was to assess the integrity and morphology of the recovered ACL after DIS repair. METHODS: The cohort comprised 47 patients with an acute proximal ACL rupture undergoing DIS repair. All patients underwent diagnostic arthroscopy after a minimum postoperative interval of 6 months for semi-quantitative evaluation of ACL integrity, function and scar tissue formation...
July 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28740761/local-application-of-statins-significantly-reduced-hypertrophic-scarring-in-a-rabbit-ear-model
#3
Shengxian Jia, Ping Xie, Seok J Hong, Robert D Galiano, Thomas A Mustoe
BACKGROUND: We previously showed that intradermal injection of statins is a successful treatment for hypertrophic scarring. Topical application has many advantages over intradermal injection. In this study, we demonstrate the efficacy of topical statin treatment in reducing scar in our validated rabbit ear scar model. METHODS: Twenty New Zealand White rabbits were divided into 2 study groups, with 6 rabbits receiving 10 μm pravastatin intradermally at postoperative days 15, 18, and 21, and 14 rabbits receiving 0...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28728694/alcohol-septal-ablation-for-obstructive-hypertrophic-cardiomyopathy-a-word-of%C3%A2-endorsement
#4
REVIEW
Max Liebregts, Pieter A Vriesendorp, Jurrien M Ten Berg
Twenty years after the introduction of alcohol septal ablation (ASA) for the treatment of obstructive hypertrophic cardiomyopathy, the arrhythmogenicity of the ablation scar appears to be overemphasized. When systematically reviewing all studies comparing ASA with myectomy with long-term follow-up, (aborted) sudden cardiac death and mortality rates were found to be similarly low. The focus should instead shift toward lowering the rate of reinterventions and pacemaker implantations following ASA because, in this area, ASA still seems inferior to myectomy...
July 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28727221/scar-formation-following-excisional-and-burn-injuries-in-a-red-duroc-pig-model
#5
Britani N Blackstone, Jayne Y Kim, Kevin L McFarland, Chandan K Sen, Dorothy M Supp, J Kevin Bailey, Heather M Powell
Scar research is challenging because rodents do not naturally form excessive scars, and burn depth, size, and location cannot be controlled in human longitudinal studies. The female, red Duroc pig model has been shown to form robust scars with biological and anatomical similarities to human hypertrophic scars. To more closely mimic the mode of injury, recreate the complex chemical milieu of the burn wound environment and enhance scar development, an animal model of excessive burn-induced scarring was developed and compared with the more commonly used model, which involves excisional wounds created via dermatome...
July 20, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28726006/microrna-21-in-skin-fibrosis-potential-for-diagnosis-and-treatment
#6
REVIEW
Yan Li, Juan Zhang, Yuying Lei, Lechun Lyu, Ruiling Zuo, Ting Chen
Skin fibrosis is a common pathological process characterized by fibroblast proliferation and excessive deposition of extracellular matrix. However, the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-21 may play pivotal roles in the regulation of a variety of skin fibrosis, including keloid, scleroderma, and hypertrophic scar. In this review, we outline the structure, expression, and regulation of microRNA-21 and its role in fibrotic skin diseases. In future, it may be useful as a prognostic or diagnostic marker...
July 19, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28708657/reconstruction-of-facial-cervical-scars-with-pedicled-expanded-deltopectoral-flap
#7
Xianjie Ma, Yang Li, Weiyang Li, Chaohua Liu, Hengxin Liu, Ping Xue, Jiangbo Cui
The facial-cervical scars bring the suffering to the patients both physically and mentally. Choosing a proper donor soft tissue is always one of the critical issues, especially to Asian patients. Among the common used donor sites, the deltopectoral site was conceived as the most suitable donor tissue for the reconstruction in face and neck for its adjacent site and match in color and texture. There were 220 patients with facial-cervical scars reconstructed by the pedicled expanded deltopectoral flap between 2007 through 2015 in the authors' hospital...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28696234/role-of-daptomycin-on-wound-healing-in-a-mrsa-burn-infected-animal-model
#8
Oriana Simonetti, Guendalina Lucarini, Fiorenza Orlando, Elisa Pierpaoli, Roberto Ghiselli, Mauro Provinciali, Pamela Castelli, Mario Guerrieri, Roberto Di Primio, Annamaria Offidani, Andrea Giacometti, Oscar Cirioni
Prolonged hospitalization and antibiotic therapy are risk factors for the development of methicillin-resistant S. aureus (MRSA) infections in thermal burn patients. We used a rat model to study the in vivo efficacy of daptomycin in the treatment of burn wound infections by S. aureus and we evaluated the wound healing process through morphological and immunohistochemical analysis. A copper bar heated in boiling water was applied on paraspinal site of each rat resulting in two full thickness burns. A small gauze was placed over each burn and inoculated with 5x10(7) cfu of S...
July 10, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28690124/microneedling-where-do-we-stand-now-a-systematic-review-of-the-literature
#9
REVIEW
Ramaut Lisa, Hoeksema Henk, Pirayesh Ali, Stillaert Filip, Monstrey Stan
BACKGROUND: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. OBJECTIVE: This review aims to evaluate the current evidence in the literature on microneedling...
June 17, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28689910/management-of-postburn-perioral-contracture-using-a-customized-static-commissural-splint-and-intralesional-injections-of-triamcinolone
#10
Saurav Kumar, Sanjeev Harbansh Gupta, M Viswambaran, Arpreeta Sachdeva, B P Panda
A perioral facial burn is usually accompanied by a reduction in size of the oral orifice because of the contraction of the healing wound. Perioral contracture leads to microstomia, restricting nutrition, speech, and jaw movements and impairing the esthetic appearance of the face. It is imperative to introduce splints as early as possible to prevent the postburn sequelae. A delay in splinting allows postburn contractures. Overcoming these contractures to regain the size of the stoma requires restructuring of the hypertrophic scar using mechanical force and the biomodification of the tissues...
July 7, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28682547/-application-of-modified-coronal-approach-in-treatment-of-craniomaxillofacial-fractures
#11
Wang Lei, Zhao Wenjie, Sun Libo, Zhou Hangyu, Wu Shuangjiang, Xiao Jingang
OBJECTIVE: This study aimed to investigate clinical efficacy of a modified coronal approach in treatment of craniomaxillofacial fractures. METHODS: Thirty-seven cases of craniomaxillofacial fractures underwent open reduction and rigid internal fixation through modified coronal approach. Clinical follow-up visits were conducted to evaluate facial nerve functional status, temporal shape, appearance restoration, and reduction of fracture and surgical area scars. RESULTS: During follow-up period of 6-36 months, appearance and function of all 37 patients recovered well without facial nerve injury and temporal depression deformity...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28676850/current-therapeutic-approach-to-hypertrophic-scars
#12
REVIEW
Zrinka Bukvić Mokos, Anamaria Jović, Lovorka Grgurević, Ivo Dumić-Čule, Krešimir Kostović, Romana Čeović, Branka Marinović
Abnormal scarring and its accompanying esthetic, functional, and psychological sequelae still pose significant challe nges. To date, there is no satisfactory prevention or treatment option for hypertrophic scars (HSs), which is mostly due to not completely comprehending the mechanisms underlying their formation. That is why the apprehension of regular and controlled physiological processes of scar formation is of utmost importance when facing hypertrophic scarring, its pathophysiology, prevention, and therapeutic approach...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28670752/sudden-cardiac-death-in-nonischemic-cardiomyopathy-refining-risk-assessment
#13
REVIEW
Matthew M Zipse, Wendy S Tzou
Sudden cardiac death (SCD) risk assessment among patients with nonischemic cardiomyopathy (NICM) has been has been less straightforward than for patients with ischemic cardiomyopathy. The common surrogate that has been associated with highest SCD risk for all cardiomyopathies, and which has been universally used to guide implantation of primary-prevention implantable cardioverter-defibrillators (ICDs), is left ventricular ejection fraction (LVEF) ≤35%. However, this practice has been called into question, especially in light of recent trials suggesting that ICD treatment may not be of additional survival benefit among those with NICM treated with optimal medical therapy...
July 3, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28669442/scar-massage-for-hypertrophic-burns-scarring-a-systematic-review
#14
REVIEW
P Ault, A Plaza, J Paratz
BACKGROUND: Scar massage is used in burn units globally to improve functional and cosmetic outcomes of hypertrophic scarring following a burn, however, the evidence to support this therapy is unknown. OBJECTIVE: To review the literature and assess the efficacy of scar massage in hypertrophic burn scars. METHODS: MEDLINE, PubMed, Embase, CINAHL and the Cochrane Library were searched using the key words "burn", "burn injury", "thermal injury" and "scar", "hypertrophic scar" and "massage", "manipulation", "soft tissue mobilisation", "soft tissue manipulation"...
June 29, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28665849/aesthetic-lateral-canthoplasty-a-gray-line-split-approach
#15
Zhang Yuanyuan, Xie Aiguo, Yu Dong
BACKGROUND: Many women in Asian countries chase larger and brighter eyes, but to most Asian people only double eye plasty and epicanthoplasty is not enough. As a result, aesthetic lateral canthoplasty, another procedure to lengthen the palpebral fissure, is becoming more and more popular. However, the current procedure of aesthetic lateral canthoplasty has many potential complications, restricting the wide application of this procedure. METHODS: Here, the authors developed a minimally invasive method through gray line split and canthopexy to achieve lateral canthoplasty...
July 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28658462/isotretinoin-and-timing-of-procedural-interventions-a-systematic-review-with-consensus-recommendations
#16
Leah K Spring, Andrew C Krakowski, Murad Alam, Ashish Bhatia, Jeremy Brauer, Joel Cohen, James Q Del Rosso, Lucia Diaz, Jeffrey Dover, Lawrence F Eichenfield, Geoffrey C Gurtner, C William Hanke, Marla N Jahnke, Kristen M Kelly, Shilpi Khetarpal, Megan A Kinney, Moise L Levy, James Leyden, Michael T Longaker, Girish S Munavalli, David M Ozog, Heidi Prather, Peter R Shumaker, Elizabeth Tanzi, Abel Torres, Mara Weinstein Velez, Abigail B Waldman, Albert C Yan, Andrea L Zaenglein
Importance: The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s. Objective: To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions performed either concurrently with, or immediately following the cessation of systemic isotretinoin therapy...
June 28, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28656236/homeobox-b9-facilitates-hypertrophic-scar-formation-via-activating-the-mitogen-activated-protein-kinase-signaling-pathway
#17
Qun Xie, Dandan Liu, Mosheng Yu, Xiaowei Wu, Yueqiang Zhao, Qiang Hu, Qi Wang
The functions and underlying mechanisms of homeobox B9 (HOXB9) in scar formation remain unclear; therefore, the present study aimed to investigate whether HOXB9 is highly expressed in hypertrophic scar formation. Immunohistochemistry was performed to examine the expression levels of laminin, fibronectin (FN), collagen type I (Col1) and HOXB9 in hypertrophic scar and healthy skin tissues, and in lentivirus‑constructed HOXB9‑overexpressed or ‑silenced fibroblasts (FBs). Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed to evaluate the mRNA and protein expression levels of HOXB9, laminin, FN, Col1, extracellular signal‑regulated kinase (ERK), c‑Jun N‑terminal kinase (JNK), p38, p‑c‑Jun N‑terminal kinase (JNK), p‑ERK and p‑p38...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28654594/comparison-of-steroid-and-botulinum-toxin-type-a-monotherapy-with-combination-therapy-for-treating-human-hypertrophic-scars-in-an-animal-model
#18
Hung-Chang Chen, Cheng-I Yen, Shih-Yi Yang, Cheng-Jen Chang, Jui-Yung Yang, Shu-Yin Chang, Shiow-Shuh Chuang, Yen-Chang Hsiao
BACKGROUND: The authors evaluated the efficacy of a combined regimen of botulinum toxin type A (Botox) and a steroid (triamcinolone acetonide) for treating hypertrophic scars in comparison with the treatment with each drug alone. METHODS: Twenty excised human hypertrophic scar fragments obtained from surgically treated burn patients were divided into four groups: negative control (group A), triamcinolone alone (group B), Botox alone (group C), and a combination of triamcinolone and Botox (group D)...
July 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28652908/case-histories-of-intense-pulsed-light-phototherapy-in-dermatology-the-hppl%C3%A2-and-ifl-%C3%A2-technologies
#19
Alessandro Martella, Mauro Raichi
The intense pulsed light (IPL) and laser technologies are widely used for skin rejuvenation and for treating several dermatological disorders such as skin dyschromia and acne, and for non-ablative dermal remodeling of rhytides and hypertrophic scars. Technological evolution is rapid. The High Power Pulsed Light™ [HPPL™] and Incoherent Fast Light™ technologies [IFL™, Novavision Group S.p.A., 20826 Misinto (MB), Italy] are recent innovations in the field of IPL technologies; IFL™ is a further evolution of the already advanced HPPL™ system...
March 13, 2017: Dermatology Reports
https://www.readbyqxmd.com/read/28650705/current-and-emerging-treatments-for-postsurgical-cleft-lip-scarring-effectiveness-and-mechanisms
#20
E Papathanasiou, C A Trotman, A R Scott, T E Van Dyke
Cleft lip with or without cleft palate is the most common congenital malformation of the head and the third-most common birth defect. Surgical repair of the lip is the only treatment and is usually performed during the first year of life. Hypertrophic scar (HTS) formation is a frequent postoperative complication that impairs soft tissue form, function, or movement. Multiple lip revision operations are often required throughout childhood, attempting to optimize aesthetics and function. The mechanisms guiding HTS formation are multifactorial and complex...
June 1, 2017: Journal of Dental Research
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