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Hypertrophic scar

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https://www.readbyqxmd.com/read/28641076/elevated-cd26-expression-by-skin-fibroblasts-distinguishes-a-profibrotic-phenotype-involved-in-scar-formation-compared-to-gingival-fibroblasts
#1
Wesley Mah, Guoqiao Jiang, Dylan Olver, Corrie Gallant-Behm, Colin Wiebe, David A Hart, Leeni Koivisto, Hannu Larjava, Lari Häkkinen
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not been tested in models more relevant for humans. We hypothesized that CD26 is highly expressed by human skin fibroblasts (SFBLs), and this associates with a profibrotic phenotype distinct from gingival fibroblasts (GFBLs). We compared CD26 expression in human gingiva and skin and in gingival and hypertrophic-like scar-forming skin wound healing in a pig model, and used three-dimensional cultures of human GFBLs and SFBLs...
June 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28632950/fibroblastic-connective-tissue-nevus-clinicopathological-and-immunohistochemical-study-of-14-cases
#2
Ilaria Pennacchia, Heinz Kutzner, Dmitry V Kazakov, Thomas Mentzel
BACKGROUND: We present herein a series of 14 lesions showing overlapping features with the newly defined benign cutaneous mesenchymal neoplasm labelled as fibroblastic connective tissue nevus (FCTN). METHODS AND RESULTS: Eight patients were male and five were female, ranging in age from 1 to 56 years. Lesions appeared as isolated nodules or plaques on the trunk (7 cases), the limbs (4 cases) and the neck (2 cases). Histologically, all cases were composed of bundles of bland spindle cells of fibroblastic/myofibroblastic lineage irregularly branching within the reticular dermis and along fibrous septa in the subcutis...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28629945/anthropometric-and-aesthetic-outcomes-for-the-nasolabial-region-in-101-consecutive-african-children-with-unilateral-cleft-lip-one-year-after-repair-using-the-anatomical-subunit-approximation-technique
#3
S Mbuyi-Musanzayi, F Tshilombo Katombe, P Lukusa Tshilobo, P Kalenga Mwenze Kayamba, K Devriendt, H Reychler
One hundred and one patients with complete or incomplete cleft lip underwent the anatomical subunit approximation technique for repair. The patients were followed up prospectively for 1year. The objective of this study was to determine the outcomes for the nasolabial area through anthropometric measurements and assessment of the Asher-McDade Aesthetic Index and Steffensen's criteria at 1year after surgery. Six assessors (three cleft surgeons and three non-surgeon medical professionals) examined cropped images; reliability was assessed using Cronbach's alpha...
June 16, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28629444/microrna-98-inhibits-the-cell-proliferation-of-human-hypertrophic-scar-fibroblasts-via-targeting-col1a1
#4
Sheng Bi, Linlin Chai, Xi Yuan, Chuan Cao, Shirong Li
BACKGROUND: Hypertrophic scarring (HS) is a severe disease, and results from unusual wound healing. Col1A1 could promote the hypertrophic scar formation, and the expression of Col1A1 in HS tissue was markedly higher than that in the normal. In present study, we aimed to identify miRNAs as post-transcriptional regulators of Col1A1 in HS. METHODS: MicroRNA-98 was selected as the key miRNA comprised in HS. The mRNA levels of miR-98 in HS tissues and the matched normal skin tissues were determined by qRT-PCR...
June 19, 2017: Biological Research
https://www.readbyqxmd.com/read/28627680/bmp%C3%A2-7-suppresses-excessive-scar-formation-by-activating-the-bmp%C3%A2-7-smad1-5-8-signaling-pathway
#5
Jingdong Guo, Quan Lin, Ying Shao, Li Rong, Duo Zhang
Scarring is the inevitable consequence of wound repair, which may cause significant physical and mental pain to patients when excessive. Bone morphogenetic protein‑7 (BMP‑7) has been proved to inhibit TGF‑β‑induced fibrosis in various tissues including dermal papilla cells. However, the effect of BMP‑7 on hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, has not been determined. To overcome this problem, the present study established a mouse model of thermal injury to investigate the inhibitory effects of BMP‑7 on scar formation...
June 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28617563/regulatory-mechanism-of-mir-29-over-tgf-%C3%AE-1-and-col1-in-scar-cells
#6
S Bi, C Cao, L-L Chai, S-R Li, D-Y Yang
OBJECTIVE: To study the regulatory mechanism of miR-29 over TGF-β1 and COL1 in scar cells. PATIENTS AND METHODS: 5 clinical cases of hypertrophic scar (HS) skin and adjacent normal skin tissues were separated into fibroblast for primary culture and subculture before being observed morphologically and standard HE staining under an ordinary optical microscope. RT-PCR method was applied to test the expression level of miR-29, TGF-β1, and COL1 mRNA. ELISA method was applied to test the expression level of extracellular matrix COL1, fibronectin (FN) and α-SMA...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28592935/surgery-on-burns-sequelae-in-developing-countries
#7
O El Ezzi, M Dolci, C Dufour, R Bossou, A de Buys Roessingh
The purpose of this study is to analyze the effectiveness of surgery and follow-up of children operated on for burn sequelae. For many years, we have organized two missions per year to Benin and Togo, one for surgery and one for follow-up. We analyzed the files of children born in Africa and victims of burns from the years 2002 to 2011. Children were referred through a non-governmental organization (NGO) and assessed in Africa by local paediatricians before and after surgery. Treatment consisted in operating on burn sequelae such as contractures, hypertrophic scars and hard cords...
March 31, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28586587/laser-myringotomy-versus-ventilation-tubes-in-otitis-media-with-effusion
#8
Mohammad Yousaf, Suhail Ahmad Malik, Tahir Haroon
OBJECTIVE: Otitis media with effusion (OME) is a leading cause of difficulty in hearing in paediatric population. Otitis media with effusion must be detected and managed early to prevent conductive hearing loss in children. It was aimed to compare results of laser myringotomy and ventilation tube insertion, in terms of hearing improvement and recurrence of Middle ear effusion (MEE). METHODS: This randomized controlled trial was conducted from February 2012 to January 2015...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28579035/measuring-satisfaction-with-appearance-validation-of-the-face-q-scales-for-double-eyelid-blepharoplasty-with-minor-incision-in-young-asians-retrospective-study-of-200-cases
#9
Baoguo Chen, Huifeng Song
BACKGROUND: Double eye-lid surgery is one of the most popular performed aesthetic procedures in young Asians. Reliable measurement of patient reported outcomes is crucial for facial aesthetics. The FACE-Q is a new patient-reported outcome tool (PRO) composed of numerous independently functioning scales and checklists designed to measure outcomes. Here we described FACE-Q scales for double eye-lid surgery with minor incision in young Asians. METHODS: 200 patients (400 eyes) aged from 21 to 30 years-old were recruited from 2012 to 2014...
May 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28570464/analysis-of-mechanical-behavior-of-dermal-fibroblasts-obtained-from-various-anatomical-sites-in-human-to-explore-the-optimum-stretch-magnitude
#10
Quan-Chen Xu, Rui-Xia Kuang, Shu-Qiang Wei, Qin Kang, Juan-Juan Wang, Zhi-Guo Wang
PURPOSE: Facial skin fibroblasts imposed with cyclic stretch at 10% magnitude display considerable mechanotransduction properties and biochemical reactions in our previous study. However, it is poorly understood how these shared traits are fully parallel to the common features across all fibroblasts derived from different skin-based anatomical regions in response to cyclic stretch stimulation. Thus, the purpose of this study was to evaluate the effects of various cyclic stretches on fibroblasts derived from multiple anatomical skin sites of human bodies, and the optimal stretch magnitude was defined based on the changes to cell mechanical behavior...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28570443/outcomes-of-geriatric-burns-treated-as-outpatients
#11
Shinsuke Tanizaki
OBJECTIVE: Most literature about geriatric burns has focused on inpatient management; therefore, our study investigated the effects of burn characteristics and preexisting medical comorbidities on treatment outcomes for geriatric burn patients treated as outpatients. METHODS: A retrospective review was conducted for 391 patients over 65 years of age seen in the emergency department of Fukui Prefectural Hospital over a 10-year period. Charts were reviewed for age, sex, burn characteristics, burn mechanisms, preexisting medical comorbidities, and treatment outcomes...
May 31, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28570253/review-of-silicone-gel-sheeting-and-silicone-gel-for-the-prevention-of-hypertrophic-scars-and-keloids
#12
Kuei-Chang Hsu, Chih-Wei Luan, Yi-Wen Tsai
BACKGROUND: Keloids and hypertrophic scars are fibroproliferative disorders of dermal tissue after skin injury. Many clinical control studies have reported evidence that silicone gel is effective in preventing and alleviating hypertrophic scarring. Whether silicone gel sheeting prevents hypertrophic scars or keloids requires clear evidence of its clinical effectiveness. OBJECTIVE: This review investigated the effectiveness of silicone gel and silicone gel sheeting for the prevention of hypertrophic or keloid scarring in patients with newly healed wounds...
May 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28569361/hypertrophic-scars-are-vitamins-and-inflammatory-biomarkers-related-with-the-pathophysiology-of-wound-healing
#13
Inês Correia-Sá, Paula Serrão, Marisa Marques, Maria A Vieira-Coelho
BACKGROUND: Hypertrophic scars are a consequence of wound healing. OBJECTIVE: The objective of the present study is to evaluate vitamin D and inflammatory biomarker plasma levels during wound healing. METHODS: A prospective study was performed in patients (n = 63) submitted to body contouring surgery. Blood samples were collected before (t 0) and 5 days after surgery (t 5). Blood cell count, protein inflammatory biomarkers, and circulating plasma levels of 25(OH)D, vitamin A and vitamin E were quantified...
June 1, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28566904/arborizing-vessels-on-dermoscopy-in-various-skin-diseases-other-than-basal-cell-carcinoma
#14
Hyunju Jin, Min-Young Yang, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
BACKGROUND: Arborizing vessels (AVs) are dermoscopically defined as telangiectasias with distinct treelike branching, and are a characteristic feature of basal cell carcinoma (BCC). However, AVs are observed in various conditions other than BCC. OBJECTIVE: The aim of this study was to investigate skin diseases showing AV and investigates dermoscopic differences between BCC and non-BCC. METHODS: Dermoscopic images showing AV were prospectively collected and classified into BCC/non-BCC...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28562226/inhibition-of-pathological-phenotype-of-hypertrophic-scar-fibroblasts-via-co-culture-with-adipose-derived-stem-cells
#15
Jingcheng Deng, Yuan Shi, Zhen Gao, Wen Jie Zhang, Xiaoli Wu, Weigang Cao, Wei Liu
Hypertrophic scar (HS) is a dermal fibroproliferative disease characterized by fibroblast over-proliferation, overproduction and deposition of the extracellular matrix (ECM). Growing evidence demonstrated that adipose derived stem cells (ASCs) secrete a plethora of trophic and anti-fibrotic factors, which suppress inflammation and ameliorate fibrosis of different tissues. However, few studies investigate their effect on repressing HS activity. This study evaluated the suppressing effect of ASCs on HS fibroblast bioactivity and the possible mechanism via a co-culture model...
May 31, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28560711/recent-advances-in-hypertrophic-scar
#16
REVIEW
Julei Zhang, Yan Li, Xiaozhi Bai, Yuehua Li, Jihong Shi, Dahai Hu
Hypertrophic scars (HTS) are predominant diseases after burn and trauma, which cause severe physiological and psychological problems. HTS have been researched for decades, and our knowledge about the mechanisms of HTS formation process has been increasing. However, the effects of currently available prevention and treatment strategies are limited. In this review, we summarize currently known mechanisms and recent studies of HTS, including extracellular matrix, matrix metalloproteinases, fibroblasts, myofibroblasts and their contraction ability, keratinocytes, growth factors, inflammatory and immune response, and stem cell treatment, hoping for a better understanding of HTS generation, development and effective translation to treatment strategies...
May 31, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28549358/-complication-analysis-in-lisfranc-fracture-dislocation
#17
R J García-Renedo, A Carranza-Bencano, R Leal-Gómez, F Cámara-Arrigunaga
OBJECTIVE: To value the complications and sequels for patients with Lisfrancs fracture-luxation (FLL). MATERIAL AND METHODS: A transverse ambispective study of cohorts was realized of 83 patients by diagnosis of Lisfrancs fracture-luxation. There was in use a protocol of withdrawal of information with variables related to the injury, clinical, therapeutic parameters, complications and scales of clinical valuation. RESULTS: 66 patients (79...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28529415/using-amniotic-membrane-as-a-novel-method-to-reduce-post-burn-hypertrophic-scar-formation-a-prospective-follow-up-study
#18
Ali Akbar Mohammadi, Shima Eskandari, Hamed Ghoddusi Johari, Ata'ollah Rajabnejad
BACKGROUND: Several studies have shown that the application of amniotic membrane as a biological dressing in the management of burns is accompanied by rapid re-epithelialisation. In this follow-up study, we aimed to evaluate the possible role of amniotic membrane as an adjunct to split thickness skin grafting on reducing itching and severity of hypertrophic scar formation. MATERIALS AND METHODS: From October 2013 to January 2015, in a prospective follow-up study, 54 patients (108 limbs) with second and third degree burns, covering 4%-15% of total body surface area (TBSA), were included in the study...
January 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28526301/mfg-e8-reprogramming-of-macrophages-promotes-wound-healing-by-increased-bfgf-production-and-fibroblast-functions
#19
Patrick Laplante, Frédéric Brillant-Marquis, Marie-Joëlle Brissette, Benjamin Joannette-Pilon, Romain Cayrol, Victor Kokta, Jean-François Cailhier
Macrophages are essential for tissue repair. They have a crucial role in cutaneous wound healing, participating actively in the inflammation phase of the process. Unregulated macrophage activation may, however, represent a source of excessive inflammation leading to abnormal wound healing and hypertrophic scars. Our research group has demonstrated that apoptotic endothelial and epithelial cells secrete Milk Fat Globule Epidermal Growth Factor-8 (MFG-E8), which has the ability to reprogram macrophages from a M1 (pro-inflammatory) to a M2 (anti-inflammatory pro-repair) phenotype...
May 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28507865/reconstitution-of-human-keloids-in-mouse-skin
#20
Ataru Sunaga, Hideaki Kamochi, Shunji Sarukawa, Hirokazu Uda, Yasushi Sugawara, Rintaro Asahi, Daekwan Chi, Shiho Nakagawa, Koji Kanayama, Kotaro Yoshimura
BACKGROUND: Keloids are a dermal fibroproliferative scar of unknown etiology. There is no good animal model for the study of keloids, which hinders the development and assessment of treatments for keloids. METHODS: Human keratinocytes and dermal fibroblasts were isolated from 3 human skin tissues: normal skin, white scars, and keloids. A mixed-cell slurry containing keratinocytes and dermal fibroblasts was poured into a double chamber implanted on the back of NOD/Shi-scid/IL-2Rγnull mice...
April 2017: Plastic and Reconstructive Surgery. Global Open
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