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Hypertrophic scar

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https://www.readbyqxmd.com/read/27901027/targeted-killing-of-myofibroblasts-by-biosurfactant-di-rhamnolipid-suggests-a-therapy-against-scar-formation
#1
Chong Shen, Lifang Jiang, Huawei Shao, Chuangang You, Guoliang Zhang, Sitong Ding, Tingwei Bian, Chunmao Han, Qin Meng
Pathological myofibroblasts are often involved in skin scarring via generating contractile force and over-expressing collagen fibers, but no compound has been found to inhibit the myofibroblasts without showing severe toxicity to surrounding physiological cells. Here we report that di-rhamnolipid, a biosurfactant secreted by Pseudomonas aeruginosa, showed potent effects on scar therapy via a unique mechanism of targeted killing the myofibroblasts. In cell culture, the fibroblasts-derived myofibroblasts were more sensitive to di-rhamnolipid toxicity than fibroblasts at a concentration-dependent manner, and could be completely inhibited of their specific functions including α-SMA expression and collagen secretion/contraction...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896191/comparison-of-the-effectiveness-of-ablative-and-non-ablative-fractional-laser-treatments-for-early-stage-thyroidectomy-scars
#2
Jin-Uk Jang, Soo-Young Kim, Eul-Sik Yoon, Woo-Kyung Kim, Seung-Ha Park, Byung-Il Lee, Deok-Woo Kim
BACKGROUND: Open thyroidectomy is conventionally performed at the anterior side of neck, which is a body part with a comparatively great degree of open exposure; due to this, postoperative scarring may cause distress in patients. We aimed to compare the effects of ablative and nonablative fractional laser treatments on thyroidectomy scars. We examined medical records in a retrospective manner and analyzed scars based on their digital images by using the modified Manchester Scar Scale (mMSS)...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27896177/anti-vascular-endothelial-growth-factor-bevacizumab-therapy-reduces-hypertrophic-scar-formation-in-a-rabbit-ear-wounding-model
#3
Do Hoon Kwak, Tae Hui Bae, Woo Seob Kim, Han Koo Kim
BACKGROUND: Hypertrophic scarring is a pathological condition that occurs after trauma or surgery. Angiogenesis occurs more often with hypertrophic scarring than with normotrophic scarring. The regulation of angiogenesis is one of the key factors in hypertrophic scar management. Vascular endothelial growth factor (VEGF) is an essential factor in the angiogenetic response. This study investigated whether decreasing the level of VEGF is effective for treating hypertrophic scarring. METHODS: Ten 8-week-old female New Zealand white rabbits were included...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27894385/-effect-of-expanded-lateral-thoracic-abdominal-flap-transferred-with-pedicle-on-repairing-large-area-of-hypertrophic-scar-after-burn-of-the-upper-extremity
#4
C D Xia, J D Xue, H P Di, J L Niu, X L Li, D Y Cao, Q Li, X H Niu
Objective: To observe the effect of expanded lateral thoracic abdominal flap transferred with pedicle on repairing large area of hypertrophic scar after burn of the upper extremity. Methods: Twelve patients with large area of secondary hypertrophic scar 8 month to 3 years after healing of burn wound on the upper extremity were hospitalized in Zhengzhou First People's Hospital from October 2008 to October 2015, with scar area ranging from 11 cm×7 cm to 20 cm×10 cm. Five patients were with limited straightening and bending of elbow...
November 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27893570/nonoperative-treatment-of-a-tracheocutaneous-fistula-in-a-burn-patient
#5
Katherine Marie Huber, Alicia Rose Billington, Loryn J Taylor, Kimberly Brown Maynell, C Wayne Cruse
Tracheocutaneous fistula (TCF) is a complication occurring after decannulation of a long-term tracheostomy and can lead to significant morbidity. We describe a case of a TCF in a burn patient treated without surgery. No previous cases have been described. A 65-year-old woman presented with symptomatic hypertrophic burn scar contractures of the anterior neck 6 months after undergoing excision and grafting of full-thickness burns to the neck and chest. She had a history of tracheostomy placement at the time of burn...
November 18, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27892645/endothelial-cell-derived-endothelin-1-is-involved-in-abnormal-scar-formation-by-dermal-fibroblasts-through-rhoa-rho-kinase-pathway
#6
Koichiro Kiya, Tateki Kubo, Kenichiro Kawai, Shinsuke Matsuzaki, Rieko Muramatsu, Daisuke Maeda, Toshihiro Fujiwara, Akimitsu Nishibayashi, Shigeyuki Kanazawa, Kenji Yano, Genki Amano, Taiichi Katayama, Ko Hosokawa
Hypertrophic scars and keloids are characterized by excessive dermal deposition of extracellular matrix due to fibroblast-to-myofibroblast differentiation. Endothelin-1 (ET-1) is primarily produced by vascular endothelial cells, and plays multiple roles in the wound-healing response and organ fibrogenesis. In this study, we investigated the pathophysiological significance of ET-1 and involvement of RhoA, a member of the Rho GTPases, in hypertrophic scar/keloid formation. We found that ET-1 expression on dermal microvascular endothelial cells (ECs) in hypertrophic scars and keloids was higher than that in normal skin and mature scars...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27886977/can-submandibular-tracheal-intubation-be-an-alternative-to-tracheotomy-during-surgery-for-major-maxillofacial-fractures
#7
Ahmed Gaber Hassanein, Ahmed M A Abdel Mabood
PURPOSE: During surgery for major maxillofacial fractures, orotracheal intubation can interfere with some surgical procedures and nasal intubation can be contraindicated or impossible. That is why tracheotomy is presented as a solution, although it carries a relatively high incidence of complications. In this study, the use of submandibular tracheal intubation is basically evaluated as an alternative to tracheotomy in such circumstances. MATERIALS AND METHODS: This prospective study was performed in patients undergoing surgery for major maxillofacial fractures in which oral intubation and/or nasal intubation have been unsuitable, impossible, or contraindicated...
November 2, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27877046/comparative-effect-and-safety-of-verapamil-in-keloid-and-hypertrophic-scar-treatment-a-meta-analysis
#8
Zhouna Li, Zhehu Jin
BACKGROUND: Keloids and hypertrophic scars are the most common types of pathological scarring. Traditionally, keloids have been considered as a result of aberrant wound healing, involving excessive fibroblast participation that is characterized by hyalinized collagen bundles. However, the usefulness of this characterization has been questioned. In recent years, studies have reported the appropriate use of verapamil for keloids and hypertrophic scars. METHODS: Searches were conducted on the databases Medline, Embase, Cochrane, PubMed, and China National Knowledge Infrastructure from 2006 to July 2016...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27875514/domino-flaps-for-repairing-of-secondary-bilateral-cleft-lip-with-severe-columella-deformity
#9
Jiao Wei, Cheng-An Chiang, Da Zhou, Qingfeng Li, Kai Liu
The patients with secondary bilateral cleft lip and nasal deformity always suffer from a serious part of the horizontal and vertical soft tissue deficiencies in the upper lip and nose, especially the columella. Normally, the Abbe flap is used to increase the soft tissue volume of upper lip. However, how to reconstruct the sever columella deficient, how to make full use of the Abbe flap and the remaining soft tissue of the upper lip, are always the problems that need to be solved by plastic surgeons. Twenty-nine patients with secondary bilateral cleft lip and severe columella deficiency were simultaneously reconstructed with several local flaps like dominos that was called "Domino sliding flaps...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27866191/the-long-non-coding-rna-lncrna8975-1-is-upregulated-in-hypertrophic-scar-fibroblasts-and-controls-collagen-expression
#10
Jun Li, Ling Chen, Chunyu Cao, Hui Yan, Bei Zhou, Yanli Gao, Qian Li, Jingyun Li
BACKGROUND/AIMS: Long non-coding RNAs (lncRNAs) are thought to play crucial roles in human diseases. However, the function of lncRNAs in hypertrophic scar formation remains poorly understood. METHODS: In this study, we investigated the expression of lncRNA8975-1 in hypertrophic scar tissues and fibroblasts by quantitative reverse transcription PCR (qRT-PCR). To investigate its function, overexpression and knockdown of lncRNA8975-1 were performed using lentivirus infection and Stealth RNAi transfection, respectively...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27857656/reverse-flow-anterolateral-thigh-perforator-an-ad-hoc-flap-for-severe-post-burn-knee-contracture
#11
H A Ismail, L E El-Bassiony
We evaluate function outcomes of the reverse-flow ALT perforator flap to reconstruct severe post-burn knee contracture. Between October 2012 and December 2014, 10 patients with severe post-burn knee contracture were subjected to reconstruction with 10 ipsilateral reversed-flow ALT perforator flaps. All the patients were male. Ages ranged from 15 to 47 years (mean = 32 years). Time from burn injury to patient presentation ranged from 2-8 months. All patients demonstrated post-burn flexion contracture of the knee joint, ranging from 35 to 75 degrees...
March 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27847546/topical-silicone-sheet-application-in-the-treatment-of-hypertrophic-scars-and-keloids
#12
Iris Westra, Frank B Niessen
Objective: Since the early 1980s, topical silicone sheets have been used in the treatment of hypertrophic scars and keloids.This study aimed to determine the optimal duration and application of these sheets. Design: multi-centered therapeutic study. Setting and participants: A total of 224 patients were included in this study; 205 patients with hypertrophic scars and 19 patients with keloids. Patients received treatment with a topical silicone sheet. Treated scars varied in age, ranging from two weeks to 62 years and treatment time ranged from one month to 16 months...
October 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27845966/chest-surgery-in-female-to-male-transgender-individuals
#13
Michael J Frederick, Aaron E Berhanu, Richard Bartlett
BACKGROUND: Societal awareness of transgender individuals has led to increased acceptance and demand for sex-confirming surgery. In female to male transsexuals, the most common procedure is removal of breast tissue to masculinize the chest. METHODS: Eighty-eight transgender patients underwent either a subcutaneous nipple-sparing mastectomy (NSM) with or without a periareolar mastopexy or nipple reduction, or bilateral mastectomies with free nipple grafts (MFNG) with or without nipple reduction...
November 15, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27837318/astrocytes-in-migration
#14
Jiang Shan Zhan, Kai Gao, Rui Chao Chai, Xi Hua Jia, Dao Peng Luo, Guo Ge, Yu Wu Jiang, Yin-Wan Wendy Fung, Lina Li, Albert Cheung Hoi Yu
Cell migration is a fundamental phenomenon that underlies tissue morphogenesis, wound healing, immune response, and cancer metastasis. Great progresses have been made in research methodologies, with cell migration identified as a highly orchestrated process. Brain is considered the most complex organ in the human body, containing many types of neural cells with astrocytes playing crucial roles in monitoring normal functions of the central nervous system. Astrocytes are mostly quiescent under normal physiological conditions in the adult brain but become migratory after injury...
November 11, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27830857/5-aminolevulinic-acid-loaded-ethosomal-vesicles-with-high-entrapment-efficiency-for-in-vitro-topical-transdermal-delivery-and-photodynamic-therapy-of-hypertrophic-scars
#15
Zheng Zhang, Yunsheng Chen, Heng Xu, Yan Wo, Zhen Zhang, Ying Liu, Weijie Su, Daxiang Cui, Yixin Zhang
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an alternative therapy for hypertrophic scars (HS), which destroys human hypertrophic scar fibroblasts (HSF). However, the poor permeability of ALA both in HS tissue and HSF significantly restricts the PDT of HS. To overcome these barriers, ALA-loaded ethosomal vesicles (ALA-ES) were developed by a pH gradient active loading method and characterized by morphology, entrapment efficiency (EE) and stability. Results show that prepared ALA-ES are homogenous spherical lamellar vesicles, 53 ± 7 nm in size, 50...
November 10, 2016: Nanoscale
https://www.readbyqxmd.com/read/27828834/serum-decorin-interleukin-1%C3%AE-and-transforming-growth-factor-%C3%AE-predict-hypertrophic-scarring-postburn
#16
Peter O Kwan, Jie Ding, Edward E Tredget
Hypertrophic scar after burn injury is a significant problem. Previous studies have examined the roles for decorin, interleukin-1β, and transforming growth factor-β1 in hypertrophic scar formation locally, but few have considered their systemic influence. The authors conducted a pilot study to examine whether serum levels of these molecules could predict hypertrophic scar formation. Serum levels were measured using enzyme-linked immunosorbent assay, and hypertrophic scar formation determined from chart reviews...
November 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27812490/comparing-two-methods-of-cryotherapy-and-intense-pulsed-light-with-triamcinolone-injection-in-the-treatment-of-keloid-and-hypertrophic-scars-a-clinical-trial
#17
Simin Shamsi Meymandi, Mahmood Moosazadeh, Azadeh Rezazadeh
OBJECTIVES: Keloid and hypertrophic scars are abnormal manifestations of wounds that occur following skin injuries in the form of local proliferation of fibroblasts and increased production of collagen. There are several ways to cure these scars; treatment must be selected based on the nature of the scars. In this clinical trial, two methods-cryotherapy and intense pulsed light (IPL)-are compared in the treatment of scars, and the results are presented in terms of improvement level, complications, and patient satisfaction...
October 2016: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/27807407/mdivi-1-inhibits-astrocyte-activation-and-astroglial-scar-formation-and-enhances-axonal-regeneration-after-spinal-cord-injury-in-rats
#18
Gang Li, Yang Cao, Feifei Shen, Yangsong Wang, Liangjie Bai, Weidong Guo, Yunlong Bi, Gang Lv, Zhongkai Fan
After spinal cord injury (SCI), astrocytes become hypertrophic, and proliferative, forming a dense network of astroglial processes at the site of the lesion. This constitutes a physical and biochemical barrier to axonal regeneration. Mitochondrial fission regulates cell cycle progression; inhibiting the cell cycle of astrocytes can reduce expression levels of axon growth-inhibitory molecules as well as astroglial scar formation after SCI. We therefore investigated how an inhibitor of mitochondrial fission, Mdivi-1, would affect astrocyte proliferation, astroglial scar formation, and axonal regeneration following SCI in rats...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27804226/in-vivo-terahertz-reflection-imaging-of-human-scars-during-and-after-the-healing-process
#19
Shuting Fan, Benjamin S Y Ung, Edward P J Parrott, Vincent P Wallace, Emma Pickwell-MacPherson
We use terahertz imaging to measure four human skin scars in vivo. Clear contrast between the refractive index of the scar and surrounding tissue was observed for all of the scars, despite some being difficult to see with the naked eye. Additionally, we monitored the healing process of a hypertrophic scar. We found that the contrast in the absorption coefficient became less prominent after a few months post-injury, but that the contrast in the refractive index was still significant even months post-injury. Our results demonstrate the capability of terahertz imaging to quantitatively measure subtle changes in skin properties and this may be useful for improving scar treatment and management...
November 2, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27798123/the-contribution-of-interleukin-2-to-effective-wound-healing
#20
Karen M Doersch, Daniel J DelloStritto, M Karen Newell-Rogers
Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust wound healing can lead to the development of either hypertrophic scarring or keloidosis, both of which can cause discomfort and can be cosmetically undesirable. Appropriate wound healing requires the interplay of a variety of factors, including the skin, the local microenvironment, the immune system, and the external environment...
October 24, 2016: Experimental Biology and Medicine
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