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Hypertrophic scar

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https://www.readbyqxmd.com/read/29787749/epidermal-hmgb1-activates-dermal-fibroblasts-and-causes-hypertrophic-scar-formation-in-reduced-hydration
#1
Jingling Zhao, Jianxing Yu, Yingbin Xu, Lei Chen, Fei Zhou, Qiyi Zhai, Jun Wu, Bin Shu, Shaohai Qi
High-mobility group box 1 (HMGB1) protein is a multifunctional cytokine involved in inflammatory reactions and is known to play a key role in tissue repair and fibrosis. However, the function of HMGB1 in fibrotic skin diseases, such as hypertrophic scar formation, remains unclear. In this study, HMGB1 was detected in the nuclei of epidermal cells in normal skin and had accumulated in the cytoplasm in hypertrophic scars. By establishing a keratinocyte-fibroblast co-culture and conditional medium treatment models, we found that a reduced hydration condition increased the expression and secretion of HMGB1 in keratinocytes, subsequently activating dermal fibroblasts...
May 19, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29785488/mir-155-inhibits-the-formation-of-hypertrophic-scar-fibroblasts-by-targeting-hif-1%C3%AE-via-pi3k-akt-pathway
#2
Xue Wu, Jun Li, Xuekang Yang, Xiaozhi Bai, Jihong Shi, Jianxin Gao, Yan Li, Shichao Han, Yijie Zhang, Fu Han, Yang Liu, Xiaoqiang Li, Kejia Wang, Julei Zhang, Zheng Wang, Ke Tao, Dahai Hu
Hypertrophic scar (HS) is a serious skin fibrotic disease characterized by the excessive proliferation of fibroblasts and often considered as a kind of benign skin tumor. microRNA-155 (miR-155) is usually served as a promising marker in antitumor therapy. In view of the similarities of hypertrophic scar and tumor, it is predicted that miR-155 may be a novel therapeutic target in clinical trials. Here we found the expression levels of miR-155 was gradually down regulated and HIF-1α was upregulated in HS tissue and HS derived fibroblasts (HFs)...
May 21, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29783207/perspectives-for-applying-the-additional-study-methods-for-diagnostics-optimization-of-postoperative-hypertrophic-scars-of-the-head-and-neck
#3
David S Avetikov, Olha P Bukhanchenko, Ihor O Ivanytskyi, Viktoriia V Aipert, Dmytro V Steblovskyi
OBJECTIVE: Introduction: The issue of improving the quality of diagnosis, prevention and treatment of patients with pathological scarring of the head and neck is being actively developed throughout the world. The aim of the research is to improve diagnostics of hypertrophic scars of the head and neck through the establishment of structural features of scar-modified tissues using RGB-system and ultrasound examination. PATIENTS AND METHODS: Materials and methods: In this study, 60 patients with hypertrophic scars of the head and neck were examined...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29781178/the-effects-of-platelet-rich-plasma-on-hypertrophic-scars-fibroblasts
#4
Seung Min Nam, Yong Bae Kim
We hypothesised that a feedback mechanism of the transforming growth factor (TGF)-β1 signalling pathway, triggered by high-level TGF-β1, activates platelet-rich plasma (PRP) release to reduce connective tissue growth factor (CTGF) production and expression of CTGF mRNA in hypertrophic scar dermal fibroblasts. Primary dermal fibroblasts were isolated from cultures of hypertrophic scars. Cells were cultured after addition of serum-free Dulbecco's modified Eagle's medium supplemented with 5% (wt/vol) PRP or platelet-poor plasma (PPP)...
May 21, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29775632/controlled-delivery-of-a-focal-adhesion-kinase-inhibitor-results-in-accelerated-wound-closure-with-decreased-scar-formation
#5
Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Formation of scars following wounding or trauma represents a significant healthcare burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, due to the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries...
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29757022/clinical-outcome-of-1064-nm-picosecond-neodymium-doped-yttrium-aluminium-garnet-laser-for-the-treatment-of-hypertrophic-scars
#6
Young-Jun Choi, Jung Yup Kim, Jae-Hui Nam, Ga-Young Lee, Won-Serk Kim
BACKGROUND: Currently no study has evaluated the effect of the novel 1064-nm picosecond neodymium-doped:yttrium aluminium garnet laser (ps-Nd:YAG) for reducing Hypertrophic scarring (HS). OBJECTIVE: The aim of this study was to verify the efficacy and safety of a 1064-nm ps-Nd:YAG in the management of HS. MATERIALS AND METHODS: A retrospective chart review and photographic analysis were conducted on patients treated with a low-fluence 1064-nm ps-Nd:YAG for HS improvement...
May 14, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29753790/il-17-promotes-scar-formation-by-inducing-macrophage-infiltration
#7
Julei Zhang, Qiao Qiao, Mengdong Liu, Ting He, Jihong Shi, Xiaozhi Bai, Yijie Zhang, Yan Li, Weixia Cai, Shichao Han, Hao Guan, Dahai Hu
Trauma or burn injuries that affect the deep dermis often produce a hypertrophic scar, which limits patients' joint movement and generates an aesthetic problem. Inflammation is believed to be one of the main pathogenic mechanisms. We found that IL-17 was increased in scar tissues from patients with hypertrophic scar compared with normal skin. Recombinant mouse IL-17 was subcutaneously injected into mice that underwent full-thickness excision surgery to investigate the role of IL-17 in scar formation. Mice stimulated with IL-17 showed aggravated fibrogenesis, delayed wound healing, and increased inflammation...
May 11, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29743500/clinical-evaluation-of-silicone-gel-in-the-treatment-of-cleft-lip-scars
#8
Chun-Shin Chang, Christopher Glenn Wallace, Yen-Chang Hsiao, Jung-Ju Huang, Zung-Chung Chen, Chee-Jen Chang, Lun-Jou Lo, Philip Kuo-Ting Chen, Jyh-Ping Chen, Yu-Ray Chen
Upper lip scars are at risk of hypertrophy. Our center therefore uses microporous tape and silicone sheeting for postoperative scar care following cleft lip repair. However, some babies have previously ingested their silicone sheeting, which has the potential for respiratory compromise or gastrointestinal obstruction. Self-dry silicone gel is reportedly also effective for preventing hypertrophic scars. Hence, we sought to test whether silicone gel, which cannot be ingested whole, might be non-inferior to silicone sheeting for controlling against upper lip scar hypertrophy...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740979/otoplasty-techniques-in-children-a-comparative-study-of-outcomes
#9
Puvesh Punj, Hsu Phie Chong, Thomas P Cundy, Michelle Lodge, Roger Woods
BACKGROUND: Numerous otoplasty techniques have been described in the literature to correct prominent ears; however, few have focused on the complication rates. We reviewed our experience aiming to assess peri-operative care requirements and complication rates. METHOD: We conducted a retrospective review of 207 otoplasty procedures performed in 119 patients over a 5-year period (2009-2014) at the Women's and Children's Hospital, Adelaide. Information pertaining to demographic details, length of stay, otoplasty technique and complications (early and late) were obtained...
May 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29731824/microrna-26a-inhibits-hyperplastic-scar-formation-by-targeting-smad2
#10
Jun Qi, Yifei Liu, Kesu Hu, Yi Zhang, Yangyang Wu, Xia Zhang
Hypertrophic scar (HS) is a fibrotic disease in which excessive extracellular matrix forms due to the response of fibroblasts to tissue damage. Novel evidence suggests that microRNAs (miRNAs or miRs) may contribute to hypertrophic scarring; however, the role of miRNAs in HS formation remains unclear. In the present study, miR-26a was significantly downregulated in HS tissues and human HS fibroblasts (hHSFs) was detected by reverse transcription-quantitative analysis. TargetScan was used to predict that mothers against decapentaplegic homolog 2 (Smad2) is a potential target gene of miR-26a and a dual-luciferase reporter assay confirmed that Smad2 was a target gene of miR-26a...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29731588/resurfacing-of-facial-acne-scars-with-a-new-variable-pulsed-er-yag-laser-in-fitzpatrick-skin-types-iv-and-v
#11
Namitha Chathra, Venkataram Mysore
Introduction: The Er:YAG laser, considered to be less effective than CO2 laser in its traditional form, in its new modulated version has variable pulse technology that is claimed to be superior to the earlier versions of the laser. Aim: The aim of the study was to check efficacy and safety of the new variable square pulse (VSP) Er:YAG laser in the management of acne scar in patients with Fitzpatrick skin types IV and V. Materials and Methods: This retrospective study consisted of 80 patients (Fitzpatrick skin types IV and V) with atrophic and hypertrophic facial acne scars...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29719102/risk-factors-for-hypertrophic-burn-scar-pain-pruritus-and-paresthesia-development
#12
Yongqiang Xiao, Yu Sun, Banghui Zhu, Kangan Wang, Pengfei Liang, Wenjun Liu, Jinfeng Fu, Shiqing Zheng, Shichu Xiao, Zhaofan Xia
Hypertrophic scar pain, pruritus, and paresthesia symptoms are major and particular concerns for burn patients. However, because no effective and satisfactory methods exist for their alleviation, the clinical treatment for these symptoms is generally considered unsatisfactory. Therefore, their risk factors should be identified and prevented during management. We reviewed the medical records of 129 post-burn hypertrophy scar patients and divided them into two groups for each of three different symptoms based on the University of North Carolina "4P" Scar Scale: patients with scar pain requiring occasional or continuous pharmacological intervention (HSc pain, n=75) vs...
May 2, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29718376/assessment-of-ablative-fractional-co2-laser-and-er-yag-laser-to-treat-hypertrophic-scars-in-a-red-duroc-pig-model
#13
Luis Rodriguez-Menocal, Stephen S Davis, Sandra Becerra, Marcela Salgado, Joel Gill, Jose Valdes, Ambar Candanedo, Shanmugasundaram Natesan, Michael Solis, Wellington Guzman, Alex Higa, Carl I Schulman, Robert J Christy, Jill Waibel, Evangelos V Badiavas
Hypertrophic scarring is a fibroproliferative process that occurs following a third-degree dermal burn injury, producing significant morbidity due to persistent pain, itching, cosmetic disfigurement, and loss of function due to contractures. Ablative fractional lasers have emerged clinically as a fundamental or standard therapeutic modality for hypertrophic burn scars. Yet the examination of their histopathological and biochemical mechanisms of tissue remodeling and comparison among different laser types has been lacking...
April 28, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29701624/efficacy-and-safety-of-a-novel-method-of-insulated-intralesional-radiofrequency-ablation-for-deep-dermal-and-subcutaneous-lesions-a-3-year-institutional-experience
#14
Sweta Subhadarshani, Vishal Gupta, Neha Taneja, Savita Yadav, Somesh Gupta
BACKGROUND: Although insulated intralesional radiofrequency ablation (IL-RFA) is being increasingly used in other specialties, not much information on its safety and efficacy in dermatology is available. OBJECTIVE: To describe our experience with insulated IL-RFA for various dermatological conditions. METHODS: This is a retrospective review of the patients who underwent IL-RFA in the past 3 years. Our technique involved creating a small window in the proximal end of plastic sheath of an intravenous cannula using a surgical blade, and then touching the RF probe to the cannula through the window to deliver the electric current...
May 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29673851/the-use-of-allogeneic-cartilage-for-grafting-in-functional-and-reconstructive-rhinoplasty
#15
Andrew M Read-Fuller, David M Yates, Alaaaldin Radwan, Alexander M Schrodt, Richard A Finn
PURPOSE: Allogeneic cartilage grafting has multiple uses in rhinoplasty. Autogenous cartilage is frequently used in cases of nasal obstruction or reconstruction, but harvesting grafts can cause complications or might be contraindicated. Rhinoplasties of the patient with cleft might require costochondral grafts. Allogeneic rib is an effective and safe alternative to autogenous grafts, prevents complications, and obviates postoperative admission after rib harvest. MATERIALS AND METHODS: Patients who had allogeneic cartilage placed during functional or reconstructive rhinoplasty were studied from 2 institutions, including 19 who had functional rhinoplasty using allogeneic Cartiform patellar cartilage grafts and 15 patients who underwent reconstructive cleft rhinoplasty with allogeneic rib cartilage...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29671882/electrocardiography-scar-quantification-correlates-with-scar-size-of-hypertrophic-cardiomyopathy-seen-by-multidetector-computed-tomography
#16
Tiago Costa Bignoto, Dalmo Antônio Ribeiro Moreira, Ricardo Garbe Habib, Edileide de Barros Correia, Ricardo Carneiro Amarante, Tannas Jatene, Mario Barbosa Guedes Nunes, Tiago Senra, Luiz Eduardo Mastrocolla
BACKGROUND: Hypertrophic cardiomyopathy (HCM), a genetically transmitted disease, is the most common genetic cardiovascular disease. Current strategies to stratify risk are expensive and concentrated in wealthy centers. Twelve-lead electrocardiography (ECG) is inexpensive and universally available and can be readily used for Selvester QRS scoring, which estimates scar size. This study aimed to establish the relation between ECG scar quantification and myocardial fibrosis (extent of myocardial delayed enhancement) in multidetector computed tomography (MDCT)...
April 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29664828/modified-2-stage-method-for-auricular-reconstruction
#17
Tengxiao Ma, Feng Xie, Zhengwen Zhang
BACKGROUND: Auricular reconstruction is one of the most challenging procedures in the field of plastic surgery. The aims of this study were to apply the modified 2-stage method to perform auricular reconstruction and to summarize the clinical experience in the past 10 years. METHODS: Auricular reconstruction was performed in 243 patients (total 254 ears) of congenital microtia using autologous costal cartilage. The whole procedure is divided into 2 stages. Stage I: the individualized framework fabricated with autologous costal cartilage is inserted into subcutaneous pocket in the mastoid region, and then the earlobe was transposed backward to connect with the lower part of the framework...
June 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29662713/are-the-skin-scar-characteristics-and-closure-of-the-parietal-peritoneum-associated-with-pelvic-adhesions
#18
Numan Çim, Erkan Elçi, Gülhan Güneş Elçi, Necat Almalı, Recep Yıldızhan
Objective: To assess whether the abdominal scar characteristics and closure of the peritoneum were associated with pelvic adhesions. Materials and Methods: Patients who had undergone cesarean section between December 2015 and February 2016 were assessed prospectively in terms of age, gravida, body mass index, number of living children, number of cesarean sections, time passed since the last cesarean section, closure status of the peritoneum in the last cesarean section, presence of other diseases, smoking status, location of incision in the abdomen (medial, pfannenstiel) scar dimensions (length, width), scar status with respect to skin (hypertrophic, flat, depressive), scar color [color change/no color change (hyperpigmented/hypopigmented)], adhesion of bowel-omentum-uterus, omentum-anterior abdominal wall, uterus-anterior abdominal wall, uterus-bladder, bladder-anterior abdominal wall, fixed uterus, and uterus-omentum-anterior abdominal wall in abdominal exploration...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29661554/effect-of-skin-graft-thickness-on-scar-development-in-a-porcine-burn-model
#19
Danielle M DeBruler, Britani N Blackstone, Kevin L McFarland, Molly E Baumann, Dorothy M Supp, J Kevin Bailey, Heather M Powell
Animal models provide a way to investigate scar therapies in a controlled environment. It is necessary to produce uniform, reproducible scars with high anatomic and biologic similarity to human scars to better evaluate the efficacy of treatment strategies and to develop new treatments. In this study, scar development and maturation were assessed in a porcine full-thickness burn model with immediate excision and split-thickness autograft coverage. Red Duroc pigs were treated with split-thickness autografts of varying thickness: 0...
April 13, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29658663/-microrna-222-regulates-proliferation-and-apoptosis-of-fibroblasts-in-hypertrophic-scar-via-matrix-metalloproteinase-1
#20
Yi Zhang, Li Zhang, Qiyu Zhang, Weilong Hong, Xiaohua Lin
<b>Objective:</b> To explore the effect of microRNA(miR)-222 on cell proliferation and apoptosis of fibroblasts in hypertrophic scar (HS) and the underlying mechanisms. <b>Methods:</b> The expression of miR-222 in the HS and the normal skin tissues was detected by real-time RT-PCR. The HS fibroblasts were transfected with miR-222 mimic and miR-222 inhibitor respectively. The cell viability was tested with MTT assay, cell cycle distribution and apoptosis were detected with flow cytometry and the expression levels of proliferation, apoptosis and cell cycle related proteins were determined with Western blot...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
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