keyword
MENU ▼
Read by QxMD icon Read
search

Hypertrophic scar

keyword
https://www.readbyqxmd.com/read/28888317/hypertrophic-burn-scar-research-from-quantitative-assessment-to-designing-clinical-sequential-multiple-assignment-randomized-trials
#1
REVIEW
Paul Diegidio, Steven Hermiz, Jonathan Hibbard, Michael Kosorok, Charles Scott Hultman
This article explores the current options for the quantitative assessment of hypertrophic burn scars. It also introduces a novel type of randomized, controlled trial, which relies on heterogeneity of the subject population to improve the predictive value of personalized treatment strategies.
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28888302/a-systematic-review-of-the-effectiveness-of-laser-therapy-for-hypertrophic-burn-scars
#2
REVIEW
Jennifer Zuccaro, Natalia Ziolkowski, Joel Fish
The objective of this systematic review was to assess the effectiveness of laser therapy for the treatment of hypertrophic burn scars. Improvements in scar symptoms following laser treatment were reported in 11 of the 12 included studies. However, issues related to overall quality and risk of bias were present in all studies. As a result, there is insufficient scientific evidence to determine the effectiveness of laser therapy from this systematic review. Future studies that use more rigorous study designs such as randomized controlled trials are needed to support the use of laser therapy for hypertrophic burn scars...
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28888301/laser-modulation-of-hypertrophic-scars-technique-and-practice
#3
REVIEW
Andrea C Issler-Fisher, Jill S Waibel, Matthias B Donelan
In this review, the authors discuss the use of laser photothermolysis and laser resurfacing in the management of hypertrophic burn scars. They provide details regarding preoperative selection, intraoperative decision making, and postoperative care.
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28888300/heterotopic-ossification-and-hypertrophic-scars
#4
REVIEW
Shailesh Agarwal, Michael Sorkin, Benjamin Levi
Burns and trauma cause superficial and deep soft tissue wounds that cannot heal to the preinjury state. Healing requires cell proliferation and differentiation into the injured tissue type, laying down extracellular matrix, often as collagens. Heterotopic ossification causes severe pain, nonhealing wounds, and restricted range of motion. Treatment includes radiation therapy, nonsteroidal anti-inflammatory drugs, bisphosphonates, and possibly surgical excision and prophylactic measures. Hypertrophic scars, nonosseous lesions caused by excessive collagen deposition, are often painful, functionally limiting, and aesthetically displeasing...
October 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/28884252/microrna-192-regulates-hypertrophic-scar-fibrosis-by-targeting-sip1
#5
Yan Li, Julei Zhang, Wei Zhang, Yang Liu, Yuehua Li, Kejia Wang, Yijie Zhang, Chen Yang, Xiaoqiang Li, Jihong Shi, Linlin Su, Dahai Hu
Hypertrophic scar (HS) is a fibro-proliferative disorder which is characterized by excessive deposition of collagen and accumulative activity of myofibroblasts. Increasing evidences have demonstrated miRNAs play a pivotal role in the pathogenesis of HS. MiR-192 is closely associated with renal fibrosis, but its effect on HS formation and skin fibrosis remains unknown. In the study, we presented that miR-192 was up-regulated in HS and HS derived fibroblasts (HSFs) compared to normal skin (NS) and NS derived fibroblasts (NSFs), accompanied by the reduction of smad interacting protein 1 (SIP1) expression and the increase of Col1, Col3 and α-SMA levels...
September 7, 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28877838/advances-in-mechanisms-for-prevention-and-treatment-of-pathological-scars-with-mesenchymal-stem-cells
#6
Li-Jiang Yu, Xiao-Jun Wang, Xiao Long
Pathological scars,including keloids and hypertrophic scars,result from aberrations in the process of physiologic wound healing.An exaggerated inflammatory process is one of the main pathophysiological contributors.Pathological scars may cause pain and pruritis,limit joint mobility,and cause a range of cosmetic deformities that affect the patient's quality of life.However,the effectiveness of currently available prevention and treatment measures remains unsatisfactory.Mesenchymal stem cells,among their multifunctional roles,have the functions of immunomodulation and promotion of angiogenesis...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28875694/small-molecular-tgf-%C3%AE-1-inhibitor-loaded-electrospun-fibrous-scaffolds-for-preventing-hypertrophic-scars
#7
Le Wang, Junchuan Yang, Bei Ran, Xinglong Yang, Wenfu Zheng, Yunze Long, Xingyu Jiang
Hypertrophic scarring (HS) is a disorder that occurs during wound healing and seriously depresses the quality of human life. Scar-inhibiting scaffolds, though bringing promise to HS prevention, face problems such as the incompatibility of the scaffold materials and the instability of bioactive molecules. Herein, we present a TGF-β1-inhibitor-doped poly(ε-caprolactone) (PCL)/gelatin (PG) coelectrospun nanofibrous scaffold (PGT) for HS prevention during wound healing. The appropriate ratio of PCL to gelatin can avoid individual defects of the two materials and achieve an optimized mechanical property and biocompatibility...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28874184/multipotent-stromal-cells-mesenchymal-stem-cells-and-fibroblasts-combine-to-minimize-skin-hypertrophic-scarring
#8
Cecelia C Yates, Melanie Rodrigues, Austin Nuschke, Zariel I Johnson, Diana Whaley, Donna Stolz, Joseph Newsome, Alan Wells
BACKGROUND: Transplantation of mesenchymal stem cells (MSC) has been proposed to improve wound healing. However, as these cells only transiently survive in the implantation site, the mechanisms underlying this beneficial healing response are associated with restorative paracrine effects of MSC matricellular factors on resident stromal cells. However, this requires that the recipient has a robust reservoir of viable cells. Here, we examine the influence of MSCs on the behavior of cotransplanted fibroblasts, in a manner to provide augmented cellular reserve to debilitated individuals, specifically focusing on matrix remodeling following in-vivo wounding...
September 5, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28873104/management-of-trauma-and-burn-scars-the-dermatologist-s-role-in-expanding-patient-access-to-care
#9
Nathanial R Miletta, Matthias B Donelan, Chad M Hivnor
Recent advances in laser surgery and our understanding of wound healing have ushered in a new era of trauma and burn scar management. Traditional therapy has centered around scar excision followed by primary closure or tissue replacement with flaps and grafts. This approach represents a perpetuation of the common fallacy that extensive scar improvement requires extensive surgical intervention. Laser surgery in conjunction with pharmacotherapy and minor tissue-conserving surgery produces well-healed and remodeled existing tissue that provides the most natural appearance and function of the skin...
July 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28869381/meek-micrografting-technique-and-its-use-in-the-treatment-of-severe-burn-injuries-at-the-university-hospital-ostrava-burn-center
#10
H Klosová, Z Němečková Crkvenjaš, J Štětinský
BACKGROUND: Early necrectomy and skin autotransplantation are prerequisites for successful treatment of extensive burns. Insufficient autograft donor site availability is a limiting factor. The Meek micrografting technique, published by C. P. Meek in 1958, appears to be a potential solution. Skin grafts are cut into micrografts and expanded at a ratio of 1:3, 1:4, 1:6 or 1:9. Thus, even in cases with limited donor site availability, it is possible to cover large areas after necrectomy...
2017: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/28866016/disintegration-of-collagen-fibrils-by-glucono-%C3%AE-lactone-an-implied-lead-for-disintegration-of-fibrosis
#11
Jayaraman Jayamani, R Ravikanth Reddy, Balaraman Madhan, Ganesh Shanmugam
Excess accumulation of collagen (fibrosis) undergoes self-aggregation, which leads to fibrillar collagen, on the extracellular matrix is the hallmark of a number of diseases such as keloids, hypertrophic scars, and systemic scleroderma. Direct inhibition or disintegration of collagen fibrils by small molecules offer a therapeutic approach to prevent or treat the diseases related to fibrosis. Herein, the anti-fibrotic property of Glucono-δ-lactone (GdL), known as acidifier, on the fibrillation and its disintegration of collagen was investigated...
August 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28861275/the-burning-issue-of-white-phosphorus-a-case-report-and-review-of-the-literature
#12
Uri Aviv, Rachel Kornhaber, Moti Harats, Josef Haik
BACKGROUND: Burns from white phosphorus are rare and remain a challenge for clinicians. White phosphorus burns are often associated with smaller surface areas and high morbidity rates. Classed as a chemical burn, white phosphorus is used for military purposes and within industry, for the manufacture of fireworks and agricultural products. CASE PRESENTATION: In this report, we discuss the case of a 40 years old female who sustained 2% Total Body Surface Area partial to full thickness burns from white phosphorus...
2017: Disaster and Military Medicine
https://www.readbyqxmd.com/read/28858549/submental-intubation-in-cases-of-panfacial-fractures-a-retrospective-study
#13
Willian Caetano Rodrigues, Willian Morais de Melo, Rafael Santiago de Almeida, Shajadi Carlos Pardo-Kaba, Celso Koogi Sonoda, Elio Hitoshi Shinohara
Surgical treatment of panfacial fractures usually requires intraoperative temporary occlusion of the teeth and simultaneous access to the nasal pyramid. In such cases, the standard method of airway management is to perform a tracheostomy, but this may be associated with a significant number of perioperative and late complications. This study aimed to determine if submental endotracheal intubation (SEI) is a viable alternative to tracheostomy, especially when short-term postoperative control of the airway is foreseen...
2017: Anesthesia Progress
https://www.readbyqxmd.com/read/28857716/chronic-cutaneous-lupus-erythematosus-presenting-as-atypical-acneiform-and-comedonal-plaque-case-report-and-literature-review
#14
M L Vieira, E R M C Marques, Y L A Leda, L F Noriega, D L Bet, G A A M Pereira
Introduction Chronic cutaneous lupus erythematosus (CCLE) usually presents as characteristic erythematous patches and infiltrated coin-shaped plaques. However, there are some atypical clinical variants that may mimic other dermatological conditions. Haroon et al. reported in 1972 an unusual presentation of CCLE with hypertrophic follicular scars seen in acne vulgaris. Acneiform presentation is one of the most rarely reported and one of the most confusing, as it resembles a very common inflammatory skin disease...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28853175/safety-of-non-ablative-fractional-laser-for-acne-scars-within-1-month-after-treatment-with-oral-isotretinoin-a-randomized-split-face-controlled-trial
#15
Sandeep S Saluja, Matthew L Walker, Erika M Summers, Payam Tristani-Firouzi, David R Smart
BACKGROUND AND OBJECTIVE: Based on reports of poor wound healing and scarring, it is currently recommended that patients wait 6 months after completion of oral isotretinoin therapy before the safe initiation of laser treatment. Our aim was to evaluate the safety of non-ablative fractional laser (NAFL) treatment for acne scars within 1 month after isotretinoin therapy. STUDY DESIGN/METHODS: This was a randomized split-face controlled trial involving 10 patients with acne scars who had completed isotretinoin treatment...
August 29, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28836196/hypertrophic-scarring-in-the-rabbit-ear-a-practical-model-for-studying-dermal-fibrosis
#16
Layla Nabai, Aziz Ghahary
Excessive fibrous tissue deposition after injury in the form of hypertrophic scar remains a major clinical challenge. The development of an animal model for such scarring has been extremely difficult because of a major difference between the healing process in laboratory animals and humans. Here, we describe the rabbit ear model for excessive dermal scarring which has some clinical and histological resemblance to human hypertrophic scar. Since its development, this model has been widely used to study the cellular and molecular biology of hypertrophic scarring and evaluate the efficacy of new therapeutic agents...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28836195/transplanting-human-skin-grafts-onto-nude-mice-to-model-skin-scars
#17
Jie Ding, Edward E Tredget
Hypertrophic scar (HTS) is a common outcome of deep dermal wound healing mainly followed mechanical, chemical, and thermal injuries in the skin. Because of the lack of the most effective prevention and treatment, it is particularly important to establish an ideal dermal animal model for improving the understanding of the pathogenesis and exploring therapeutic approaches of HTS. Compared to other dermal fibrotic animal models in rabbits, red Duroc pigs, guinea pigs, rats, and mice, the approach that uses normal human split-thickness skin grafted onto nude or other immunodeficient mice which develop scars that resemble human HTS offers the advantages of lower cost, easier manipulation, and shorter research period...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28820426/burn-eschar-stimulates-fibroblast-and-adipose-mesenchymal-stromal-cell-proliferation-and-migration-but-inhibits-endothelial-cell-sprouting
#18
Hanneke N Monsuur, Lenie J van den Broek, Renushka L Jhingoerie, Adrianus F P M Vloemans, Susan Gibbs
The majority of full-thickness burn wounds heal with hypertrophic scar formation. Burn eschar most probably influences early burn wound healing, since granulation tissue only forms after escharotomy. In order to investigate the effect of burn eschar on delayed granulation tissue formation, burn wound extract (BWE) was isolated from the interface between non-viable eschar and viable tissue. The influence of BWE on the activity of endothelial cells derived from dermis and adipose tissue, dermal fibroblasts and adipose tissue-derived mesenchymal stromal cells (ASC) was determined...
August 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28819623/pharyngocutaneous-fistula-as-a-rare-late-postoperative-complication-following-submandibulectomy-a-case-report
#19
Leila Mashali, Somayeh Araghi
INTRODUCTION: Submandibular gland excision is the gold standard treatment for submandibular gland disease. Although submandibulectomy is a relatively standardized surgical procedure, complications are frequently reported. These complications include nerve paralysis or paresis, aesthetic sequelae, hematoma, salivary fistulas or sialoceles, wound infections, hypertrophic scars and inflammations caused by residual lithiasis in the salivary duct. CASE REPORT: We report a case of a rare complication of submandibular gland excision, pharyngocutaneous fistula, which appeared 6 years after previous surgery...
July 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28819469/aggressive-fibromatosis-of-the-oral-cavity-in-a-5-year-old-boy-a-rare-case-report
#20
Keerthi Krishnankutty Nair, Kanad Chaudhuri, Ashok Lingappa, Ranjani Shetty, Pramod Gujjar Vittobarao
Fibrous tissue proliferations express a wide spectrum of histologic and morphologic variation in both infants and adults. This ranges from hypertrophic scar formation at one end to malignant fibrosarcoma at the other end of the spectrum. Aggressive fibromatosis is an intermediate tumor which is in proximity to fibrosarcomas. These are locally invasive and often recur after excision, but do not metastasize. Histologically, they are characterized by proliferating fibroblasts with little mitotic activity. Aggressive fibromatosis in the head and neck region is not common, and very sporadically occurs in the oral cavity or jaw bones...
2017: Pan African Medical Journal
keyword
keyword
106245
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"