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https://www.readbyqxmd.com/read/29677525/insights-from-diversified-anti-angiogenic-models-role-of-%C3%AE-interferon-inducer-deae-dextran
#1
Anita K Bakrania, Bhavesh C Variya, Snehal S Patel
BACKGROUND: Angiogenesis, the physiological process involving growth of new blood vessels from preexisting vessels, is essential for organ growth and repair. However, the imbalance in angiogenesis contributes to copious pathologies including cancer. Preceding the development of anti-angiogenic or proangiogenic agents, its evaluation is equally imperative; hence, precise and adequate models required. Valid mammalian models are expensive, time-consuming and not easy to set up, instigating legal and ethical aspects making it necessary to establish models with satisfactory activity and limited drawbacks...
April 17, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29675443/left-ventricular-intussusception-of-an-intimal-flap-in-an-aortic-dissection-stanford-type-a
#2
Tim Kaufeld, Malakh Shrestha, Axel Haverich, Andreas Martens
A 75-year-old woman was admitted to the emergency department with severe and sudden chest pain. Transthoracic echocardiogram showed an unusual case of aortic dissection Stanford Type A with complete circumferential detachment of the ascending aorta intima. An intussusception of the intima flap into the left ventricular outflow tract was also observed. This case presents a very rare surgical treatment involving root repair using tissue adhesives for a left ventricular intimal flap.
June 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29675442/thoracic-endovascular-aortic-repair-for-aortoesophageal-fistula-after-covered-rupture-of-aortic-homograft-a-durable-option
#3
Michal Nozdrzykowski, Jens Garbade, Steffen Leinung, Andrej Schmidt, Friedrich-Wilhelm Mohr, Michael A Borger
A 63-year-old woman underwent replacement of the aortic root, ascending aorta, and partial arch due to Type A aortic dissection. Shortly thereafter, a replacement of the distal aortic arch and descending aorta was performed. Three years later, the patient developed an aortoesophageal fistula (AEF) resulting in re-replacement of the distal aortic arch and proximal descending aorta with a cryopreserved aortic homograft. Six weeks post-discharge, the patient was readmitted due to recurrent AEF. A thoracic endovascular stent graft was implanted to cover the aortic rupture, followed by correction of an esophageal lesion...
June 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29675441/acute-bilateral-lower-extremity-paralysis-secondary-to-acute-thrombosis-of-an-infrarenal-abdominal-aortic-aneurysm
#4
T Joseph Watson, W Kurtis Childers, Lindsey Haga, John Calaitges
We present the case of a 64-year-old male who presented to the emergency department with bilateral limb ischemia and paralysis for approximately 1 hour. Computed tomographic angiography demonstrated occlusion of the infrarenal aorta beginning just above the patient's known abdominal aortic aneurysm (AAA) and extending into both common iliac arteries. He was emergently treated via open repair of the AAA with a Gore-Tex tube graft, bilateral common iliac thrombectomies, and bilateral lower extremity four-compartment fasciotomies...
June 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29675440/multi-velocity-encoding-four-dimensional-flow-magnetic-resonance-imaging-in-the-assessment-of-chronic-aortic-dissection
#5
Andrew G Sherrah, Fraser M Callaghan, Rajesh Puranik, Richmond W Jeremy, Paul G Bannon, Michael P Vallely, Stuart M Grieve
Background: Chronic descending thoracic aortic dissection (CDTAD) following surgical repair of ascending aortic dissection requires long-term imaging surveillance. We investigated four-dimensional (4D)-flow magnetic resonance imaging (MRI) with a novel multi-velocity encoding (multi-VENC) technique as an emerging clinical method enabling the dynamic quantification of blood volume and velocity throughout the cardiac cycle. Methods: Patients with CDTAD (n = 10; mean age, 55...
June 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29675439/coronary-events-in-patients-presenting-for-repair-of-acute-type-a-aortic-dissection
#6
Paul C Tang, Shahab A Akhter, Satoru Osaki, Lucian Lozonschi, Takushi Kohmoto, Nilto C De Oliveira
Background: Preoperative coronary angiography is often not performed in acute Type A dissection. We examined differences in the incidence of pre-existing coronary disease and subsequent coronary events between patients undergoing acute Type A dissection repair and patients undergoing elective proximal aortic aneurysm repair. Methods: From 2000 to 2015, there were 154 acute Type A dissection repairs and 457 elective proximal aortic aneurysm repairs. We performed a retrospective review to evaluate preoperative coronary disease and postoperative coronary interventions such as percutaneous coronary intervention (PCI) and coronary bypass grafting (CABG)...
June 2017: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/29673811/endovascular-aortic-repair-follow-up-protocol-based-on-contrast-enhanced-ultrasound-is-safe-and-effective
#7
Emiliano Chisci, Linda Harris, Azzurra Guidotti, Angelica Pecchioli, Clara Pigozzi, Enrico Barbanti, Leonardo Ercolini, Stefano Michelagnoli
OBJECTIVES: The aim of this study was to define the safety and effectiveness of a contrast enhanced ultrasound (CEUS) based follow up for endovascular aortic repair (EVAR) surveillance at a mid-term period (4 years). METHODS: At the tertiary referral centre EVAR surveillance was based on plain abdominal radiograph and duplex ultrasound (CDU), with computed tomography angiography (CTA) reserved for any non-diagnostic imaging during the period 1999-2011 (Group A)...
April 17, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29673638/outcome-after-surgery-for-aortic-dissection-type-a-in-morbidly-obese-patients
#8
Maximilian Kreibich, Bartosz Rylski, Joseph E Bavaria, Emanuela Branchetti, Daniel Dohle, Patrick Moeller, Prashanth Vallabhajosyula, Wilson Y Szeto, Nimesh D Desai
BACKGROUND: The number of obese patients is increasing and more obese patients are likely to present for surgical repair of aortic dissection Type A (ADA). We evaluated the effect of this procedure on mortality and morbidity of patients based on their body-mass-index (BMI; kg*m-2 ). METHODS: A total of 667 patients that underwent surgical repair of ADA between 2003 and 2017 were retrospectively analyzed. Patients were divided into four groups according to BMI: normal weight (18≤BMI<25; n=186), overweight (25≤BMI<30; n=238), obese (30≤BMI<35, n=144), and morbidly obese (BMI≥35; n=99)...
April 16, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29673380/a-standardized-approach-to-treat-complex-aortic-valve-endocarditis-a-case-series
#9
Anna Gomes, Jayant S Jainandunsing, Sander van Assen, Peter Paul van Geel, Bhanu Sinha, Sandro Gelsomino, Daniel M Johnson, Ehsan Natour
BACKGROUND: Surgical treatment of complicated aortic valve endocarditis often is challenging, even for experienced surgeons. We aim at demonstrating a standardized surgical approach by stentless bioprostheses for the treatment of aortic valve endocarditis complicated by paravalvular abscess formation. METHODS: Sixteen patients presenting with aortic valve endocarditis (4 native and 12 prosthetic valves) and paravalvular abscess formation at various localizations and to different extents were treated by a standardized approach using stentless bioprostheses...
April 19, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29673298/initial-clinical-experience-using-the-low-profile-altura-endograft-system-with-double-d-shaped-proximal-stents-for-endovascular-aneurysm-repair
#10
Dainis Krievins, Albrecht Krämer, Janis Savlovskis, Georgij Oszkinis, E Sebastian Debus, Alexander Oberhuber, Christopher K Zarins
PURPOSE: To report the initial clinical results of endovascular aneurysm repair (EVAR) using the low-profile (14-F) Altura Endograft System, which features a double "D-shaped" stent design with suprarenal fixation and modular iliac components that are deployed from distal to proximal. METHODS: From 2011 to 2015, 90 patients (mean age 72.8±8.3 years; 79 men) with abdominal aortic aneurysm (AAA; mean diameter 53.8±5.7 mm) were treated at 10 clinical sites in 2 prospective, controlled clinical studies using the Altura endograft...
April 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29672613/intravascular-ultrasound-assisted-sizing-in-thoracic-endovascular-aortic-repair-improves-aortic-remodeling-in-type-b-aortic-dissection
#11
Julia Lortz, Konstantinos Tsagakis, Christos Rammos, Michael Horacek, Thomas Schlosser, Heinz Jakob, Tienush Rassaf, Rolf Alexander Jánosi
The precise sizing of the stent graft in thoracic endovascular aortic repair (TEVAR) affects aortic remodeling and hence, further outcome. Covering the proximal entry tear is essential for successful treatment of Type B aortic dissection. Intravascular ultrasound (IVUS) enables real-time aortic diameter assessment, and is especially useful when computed tomography (CT) image quality is poor. IVUS, however, is not routinely utilized due to cost inefficiency. We investigated the impact of IVUS-assisted stent graft sizing on aortic remodeling in TEVAR...
2018: PloS One
https://www.readbyqxmd.com/read/29672411/the-weekend-effect-in-aaa-repair
#12
Thomas F X O'Donnell, Chun Li, Nicholas J Swerdlow, Patric Liang, Alexander B Pothof, Virendra I Patel, Kristina A Giles, Mahmoud B Malas, Marc L Schermerhorn
BACKGROUND: Conflicting reports exist regarding whether patients undergoing surgery on the weekend or later in the week experience worse outcomes. METHODS: We identified patients undergoing abdominal aortic aneurysm (AAA) repair in the Vascular Quality Initiative between 2009 and 2017 [n = 38,498; 30,537 endovascular aneurysm repair (EVAR) and 7961 open repair]. We utilized mixed effects logistic regression to compare adjusted rates of perioperative mortality based on the day of repair...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29667078/impact-of-different-coarctation-therapies-on-aortic-stiffness-phase-contrast-mri-study
#13
Michal Schäfer, Gareth J Morgan, Max B Mitchell, Michael Ross, Alex J Barker, Kendall S Hunter, Brian Fonseca, Michael DiMaria, Daniel Vargas, D Dunbar Ivy, Neil Wilson, Lorna P Browne
Coarctation of the aorta has been associated with increased thoracic aortic stiffness in adolescents and young adults. However, the effects of different therapeutic strategies on aortic stiffness in a young population is unknown. This study aimed to non-invasively assess aortic stiffness between different repair or intervention strategies in patients with coarctation of the aorta. Forty-nine coarctation patients who underwent either surgery (n = 26), balloon angioplasty (n = 14), or stent implantation (n = 12), and 26 age- and size-matched normotensive healthy controls underwent evaluation of thoracic aortic stiffness and flow hemodynamics via phase-contrast cardiac magnetic resonance...
April 17, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29666905/balloon-occluded-carbon-dioxide-gas-angiography-for-internal-iliac-arteriography-and-intervention
#14
Mitsuhiro Kishino, Shuichiro Nakaminato, Yoshio Kitazume, Naoyuki Miyasaka, Toshifumi Kudo, Yukihisa Saida, Ukihide Tateishi
INTRODUCTION: The usefulness of carbon dioxide (CO2 ) gas digital subtraction angiography (DSA) has been reported for patients with renal insufficiency and allergy to iodinated contrast agents. However, CO2 gas cannot replace the iodinated contrast agent in all cases owing to some disadvantages. We describe balloon-occluded CO2 DSA (B-CO2 DSA) as an improved CO2 DSA procedure for interventions in the internal iliac artery (IIA) region and compare the quality of images obtained using conventional CO2 DSA and B-CO2 DSA...
April 17, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29666015/patient-selection-could-be-the-holy-grail-of-thoracic-endovascular-aortic-repair-for-chronic-dissecting-aneurysm
#15
EDITORIAL
Ourania Preventza, Peter Chen
No abstract text is available yet for this article.
March 28, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29666009/in-vitro-validation-of-a-self-driving-aortic-turbine-venous-assist-device-for-fontan-patients
#16
Kerem Pekkan, Ibrahim Basar Aka, Ece Tutsak, Erhan Ermek, Haldun Balim, Ismail Lazoglu, Riza Turkoz
BACKGROUND: Palliative repair of single ventricle defects involve a series of open-heart surgeries where a single-ventricle (Fontan) circulation is established. As the patient ages, this paradoxical circulation gradually fails, because of its high venous pressure levels. Reversal of the Fontan paradox requires an extra subpulmonic energy that can be provided through mechanical assist devices. The objective of this study was to evaluate the hemodynamic performance of a totally implantable integrated aortic-turbine venous-assist (iATVA) system, which does not need an external drive power and maintains low venous pressure chronically, for the Fontan circulation...
March 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29665666/-early-results-of-fenestrated-endovascular-aortic-repair-for-the-treatment-of-patients-with-thoracoabdominal-pathologies
#17
J C Zhu, X C Dai, Y D Luo, H L Fan, Z Feng, Y W Zhang, F G Hu
Objective: To evaluate the early results of fenestrated endovascular aortic repair (FEVAR) using physician-modified stent grafts (PMSGs) for the treatment of patients with thoracoabdominal pathologies. Methods: Nineteen consecutive patients who underwent FEVAR using PMSGs between April 2012 and September 2017 were retrospectively reviewed. The modality of FEVAR technique was assessed, perioperative clinical data was recorded and the early results were evaluated. Results: Indications were thoracoabdominal aortic pathologies, including juxtarenal abdominal aortic aneurysm (JAAA) ( n =12), chronic thoracoabdominal aortic dissection with aneurysmal dilatation ( n =3), thoracoabdominal aortic aneurysm (TAAA) ( n =1), infrarenal AAA with an accessory renal artery in the segment of the aneurysmal neck ( n =2) and type Ⅰ endoleak after EVAR for AAA( n =1)...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29664316/endovascular-repair-of-interrupted-aortic-arch-approach-with-hope-for-fewer-complications
#18
Ata Firouzi, Bahram Mohebbi, Ali Shafiei
Interrupted aortic arch (IAA) is a rare congenital malformation defined as complete discontinuity between ascending and descending parts of aorta. We present a case of IAA, which was referred to us due to dilatation of proximal and mid parts of his thoracic aorta accompanied by narrowing of aorta proximal to the branching of the left subclavian artery. Further evaluation revealed interruption of aorta at the proximal part of descending thoracic aorta by a transverse septum along with several collateral formations...
December 23, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29663146/thoraco-lumbar-fractures-with-blunt-traumatic-aortic-injury-in-adult-patients-correlations-and-management
#19
Giorgio Santoro, Alessandro Ramieri, Vito Chiarella, Massimo Vigliotta, Maurizio Domenicucci
PURPOSE: Traumatic thoraco-lumbar spine fracture spine with a concomitant blunt aortic injury is uncommon but potentially a fatal association. Our aim was to clarify: morphology of spinal fractures related to vascular damages and vice versa, diagnostic procedures and decision-making process for the best treatment options for spine and vessels. METHODS: We enrolled 42 cases culled from the literature and five personal ones, reviewing in detail by AO Spine Classification, Society of Vascular Surgery classification and Abbreviated Injury Scale for neurological evaluation...
April 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29662705/aortitis-as-a-rare-cause-of-aortic-aneurysm-and-valve-regurgitation-is-repair-precluded
#20
Carlos Porras, Gemma Sanchez-Espin, Miguel Such, Jesús Sánchez-Ramos, Alicia Bautista-Pavés, Pilar Martín-de la Fuente, Josefa Ruiz, Norberto Ortego-Centeno, Isabel Rodríguez-Bailón, José María Melero
Aortitis is an infrequent cause of aortic root dilatation and aortic valve regurgitation. Valve-sparing procedures have been proposed, but there is not clear evidence of which is the treatment of choice. We report the case of a 38-year-old pregnant lady with a diagnosis of idiopathic aortitis associated with aortic root aneurysm and severe aortic valve regurgitation.
2018: Case Reports in Cardiology
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