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https://www.readbyqxmd.com/read/27882706/high-frequency-of-potential-interactions-between-direct-acting-antivirals-and-concomitant-therapy-in-hiv-hepatitis-c-virus-coinfected-patients-in-clinical-practice
#1
J Macías, P Monge, M Mancebo, N Merchante, K Neukam, L M Real, J A Pineda
OBJECTIVES: The aim of the study was to analyse the frequency and degree of potential drug-drug interactions (DDIs) between direct-acting antivirals (DAAs) and concomitant medication used by HIV/hepatitis C virus (HCV)-coinfected patients, including antiretroviral therapy (ART) and other drugs. METHODS: All patients with HIV infection and viraemic HCV genotype 1, 3 or 4 coinfection attending a tertiary care centre in Spain (November 2014 to November 2015) were included in the study...
November 24, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27549000/the-efficacy-and-safety-of-direct-acting-antiviral-treatment-and-clinical-significance-of-drug-drug-interactions-in-elderly-patients-with-chronic-hepatitis-c-virus-infection
#2
J Vermehren, K-H Peiffer, C Welsch, G Grammatikos, M-W Welker, N Weiler, S Zeuzem, T M Welzel, C Sarrazin
BACKGROUND: Direct antiviral therapies for chronic hepatitis C virus (HCV) infection have expanded treatment options for neglected patient populations, including elderly patients who are ineligible/intolerant to receive interferon (IFN)-based therapy. AIM: To investigate the efficacy, tolerability and potential for drug-drug interactions (DDIs) of IFN-free treatment in patients aged ≥65 years in a large real-world cohort. METHODS: A total of 541 patients were treated with different combinations of direct antiviral agents (DAAs: ledipasvir/sofosbuvir ±ribavirin; daclatasvir/sofosbuvir ±ribavirin; paritaprevir/ombitasvir ±dasabuvir ±ribavirin or simeprevir/sofosbuvir ±ribavirin in genotype 1/4, and daclatasvir/sofosbuvir ±ribavirin or sofosbuvir/ribavirin in genotype 2/3)...
October 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27419177/antiretroviral-use-in-the-cease-cohort-study-and-implications-for-direct-acting-antiviral-therapy-in-human-immunodeficiency-virus-hepatitis-c-virus-coinfection
#3
Marianne Martinello, Gregory J Dore, Jasmine Skurowski, Rohan I Bopage, Robert Finlayson, David Baker, Mark Bloch, Gail V Matthews
Background.  Interferon-free direct-acting antiviral (DAA) regimens for hepatitis C virus (HCV) provide a major advance in clinical management, including in human immunodeficiency virus (HIV)/HCV coinfection. Drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) require consideration. This study aimed to characterize the cART regimens in HIV/HCV-coinfected individuals and assess the clinical significance of DDIs with DAAs in a real-world cohort. Methods.  This analysis included participants enrolled in CEASE-D, a prospective cohort of HIV/HCV-coinfected individuals in Sydney, Australia, between July 2014 and December 2015...
April 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27257014/dtb-select-6-june-2016
#4
(no author information available yet)
EMA reviews risk of pneumonia with inhaled corticosteroids for COPD ● Updated USA guidance on opioids for chronic pain ● Tackling high-risk prescribing ● Influencing antibiotic prescribing in primary care ● Commuting, BMI and obesity ● Cardiovascular effects of antidepressants ● PPI use and dementia ● Older people and risk of drug interactions.
June 2016: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/26971988/-predictive-factors-of-clinically-significant-drug-drug-interactions-among-regimens-based-on-protease-inhibitors-non-nucleoside-reverse-transcriptase-inhibitors-and-raltegravir
#5
Miguel Cervero, Rafael Torres, Juan José Jusdado, Susana Pastor, Jose Luis Agud
BACKGROUND AND OBJECTIVE: To determine the prevalence and types of clinically significant drug-drug interactions (CSDI) in the drug regimens of HIV-infected patients receiving antiretroviral treatment. MATERIAL AND METHODS: HASH(0x41e49b0) DESIGN: retrospective review of database. Centre: Hospital Universitario Severo Ochoa, Infectious Unit. PARTICIPANTS: one hundred and forty-two participants followed by one of the authors were selected from January 1985 to December 2014...
April 15, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/26611779/drug-drug-interactions-with-novel-all-oral-interferon-free-antiviral-agents-in-a-large-real-world-cohort
#6
Christoph Höner Zu Siederdissen, Benjamin Maasoumy, Fiona Marra, Katja Deterding, Kerstin Port, Michael P Manns, Markus Cornberg, David Back, Heiner Wedemeyer
BACKGROUND: With the approval of direct-acting antivirals (DAAs), the management of drug-drug interactions (DDIs) has become an important challenge while treating individuals with hepatitis C. To date, the potential of causing DDIs for the recently approved DAAs has not been systematically investigated. We aimed to assess the clinical significance of DDI between the regular outpatient medications and DAA therapies in a large real-world cohort. METHODS: Overall, 261 hepatitis C virus monoinfected patients who were selected for DAA therapy at 2 intervals between 2011 and 2014 were asked about their regular outpatient medications...
March 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26286575/prevalence-and-type-of-drug-drug-interactions-involving-art-in-patients-attending-a-specialist-hiv-outpatient-clinic-in-kampala-uganda
#7
K Seden, C Merry, R Hewson, M Siccardi, M Lamorde, P Byakika-Kibwika, E Laker, R Parkes-Ratanshi, D J Back, S H Khoo
OBJECTIVES: Scale-up of HIV services in sub-Saharan Africa has rapidly increased, necessitating evaluation of medication safety in these settings. Drug-drug interactions (DDIs) involving antiretrovirals (ARVs) in sub-Saharan Africa are poorly characterized. We evaluated the prevalence and type of ARV DDIs in Ugandan outpatients and identified the patients most at risk. METHODS: A total of 2000 consecutive patients receiving ARVs at the Infectious Diseases Institute, Kampala were studied...
December 2015: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/25397508/potential-drug-drug-interactions-in-hiv-perinatally-infected-adolescents-on-antiretroviral-therapy-in-buenos-aires-argentina
#8
Ezequiel Cordova, Diego Cecchini, Claudia Rodriguez
INTRODUCTION: An increasing number of treatment-experienced perinatally HIV-infected adolescents (PHA) are being transitioned from paediatric centres to adult HIV-care [1]. Most of them had been heavily exposed to antiretroviral drugs (ARVs), harbour drug-resistant viruses and require non-antiretroviral medication due to comorbidities [2]. This may predispose for clinically significant drug-drug interactions (CSDDIs) [3]. There are no studies concerning CSDDIs in PHA. We aimed to evaluate the prevalence of concomitant medications and CSDDIs in PHA who were transitioned for adult HIV-care to the Infectious Diseases Unit, Cosme Argerich Hospital, Buenos Aires City, Argentina...
2014: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/22550277/antihypertensive-drugs-in-patients-treated-with-antiretrovirals
#9
REVIEW
Hélène Peyriere, Céline Eiden, Jean-Christophe Macia, Jacques Reynes
OBJECTIVE: To review the literature for information regarding pharmacokinetic interactions between antiretrovirals and antihypertensive agents, evaluate the clinical significance of these interactions, and analyze the effect of antihypertensive drugs on the metabolic complications frequently observed in HIV-infected patients to emphasize the advantages and inconveniences of every class of antihypertensive drugs in association with antiretrovirals. DATA SOURCES: A literature search was conducted via PubMed and MEDLINE (1950-November 2011) using the search terms drug interactions, cytochrome P450, names of antiretrovirals, names of commonly prescribed antihypertensive drugs, pharmacokinetics, and metabolic complications...
May 2012: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/21208819/drug-interactions-of-new-antiretroviral-drugs
#10
REVIEW
J I Serrano López de Las Hazas
A systematic review was made of the drug interactions of new antiretroviral drugs. In order to do this a search was made in Pubmed to find articles published from January 2007 to September 2009 and the full-text articles which contained information about new antiretroviral drugs were selected. This search was then complemented with information from the technical specifications of the drugs and consultations made on webpages specialized in antiretroviral interactions: www.interaccioneshiv.com and www.hiv-druginteractions...
January 2011: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/20607670/-cushing-syndrome-after-steroid-infiltration-in-two-hiv-patients-with-antiretroviral-therapy
#11
M A Herold, H F Günthard
The introduction of antiretroviral treatment with at least three active drugs has caused a substantial reduction of morbidity and mortality. Some antiretroviral drugs have the potential of interactions with other drugs. With the so called <boosted> protease inhibitors the cytochrom-P450 inhibition by Ritonavir is used to increase the plasma level of the protease inhibitor. This strategy results in prolonged dosage intervals and reduced tablet intake due to a reduced overall dose that is needed. The interaction potential of Ritonavir originates from this cytochrom P450-inhibition...
July 7, 2010: Praxis
https://www.readbyqxmd.com/read/19665485/pharmacokinetics-and-drug-drug-interactions-of-antiretrovirals-an-update
#12
REVIEW
Laura Dickinson, Saye Khoo, David Back
Current antiretroviral treatment has allowed HIV infection to become a chronic manageable condition with many HIV patients living longer. However, available antiretrovirals are not without limitations, for example the development of resistance and adverse effects. Consequently, new drugs in existing and novel classes are urgently required to provide viable treatment options to patients with few remaining choices. Darunavir, etravirine, maraviroc and raltegravir have been recently approved for treatment-experienced patients and other agents such as rilpivirine, vicriviroc and elvitegravir are currently under phase III study...
January 2010: Antiviral Research
https://www.readbyqxmd.com/read/18574025/the-largest-prospective-warfarin-treated-cohort-supports-genetic-forecasting
#13
MULTICENTER STUDY
Mia Wadelius, Leslie Y Chen, Jonatan D Lindh, Niclas Eriksson, Mohammed J R Ghori, Suzannah Bumpstead, Lennart Holm, Ralph McGinnis, Anders Rane, Panos Deloukas
Genetic variants of cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose, but the effect of other genes has not been fully elucidated. We genotyped 183 polymorphisms in 29 candidate genes in 1496 Swedish patients starting warfarin treatment, and tested for association with response. CYP2C9*2 and *3 explained 12% (P = 6.63 x 10(-34)) of the variation in warfarin dose, while a single VKORC1 SNP explained 30% (P = 9.82 x 10(-100)). No SNP outside the CYP2C gene cluster and VKORC1 regions was significantly associated with dose after correction for multiple testing...
January 22, 2009: Blood
https://www.readbyqxmd.com/read/18378963/new-era-in-drug-interaction-evaluation-us-food-and-drug-administration-update-on-cyp-enzymes-transporters-and-the-guidance-process
#14
REVIEW
Shiew-Mei Huang, John M Strong, Lei Zhang, Kellie S Reynolds, Srikanth Nallani, Robert Temple, Sophia Abraham, Sayed Al Habet, Raman K Baweja, Gilbert J Burckart, Sang Chung, Philip Colangelo, David Frucht, Martin D Green, Paul Hepp, Elena Karnaukhova, Hon-Sum Ko, Jang-Ik Lee, Patrick J Marroum, Janet M Norden, Wei Qiu, Atiqur Rahman, Solomon Sobel, Toni Stifano, Kenneth Thummel, Xiao-Xiong Wei, Sally Yasuda, Jenny H Zheng, Hong Zhao, Lawrence J Lesko
Predicting clinically significant drug interactions during drug development is a challenge for the pharmaceutical industry and regulatory agencies. Since the publication of the US Food and Drug Administration's (FDA's) first in vitro and in vivo drug interaction guidance documents in 1997 and 1999, researchers and clinicians have gained a better understanding of drug interactions. This knowledge has enabled the FDA and the industry to progress and begin to overcome these challenges. The FDA has continued its efforts to evaluate methodologies to study drug interactions and communicate recommendations regarding the conduct of drug interaction studies, particularly for CYP-based and transporter-based drug interactions, to the pharmaceutical industry...
June 2008: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/10674190/cytochrome-p450-mediated-drug-interactions
#15
REVIEW
D A Flockhart, J R Oesterheld
In this article, the authors have provided child psychiatrists with cytochromal concepts, illustrations of common CYP-based drug interactions, and CYP tables. Clinicians can use these tables to anticipate drug interactions. If two medications are listed on the same CYP, a drug interaction may occur, and depending on whether they are substrates, inducers, or inhibitors, clearance of one or both drugs may be altered. Because new information about CYPs rapidly becomes available, however, CYP tables have a short shelf life...
January 2000: Child and Adolescent Psychiatric Clinics of North America
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