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renal cell carcinoma radiology

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https://www.readbyqxmd.com/read/27878338/reporting-standards-for-the-imaging-based-diagnosis-of-renal-masses-on-ct-and-mri-a-national-survey-of-academic-abdominal-radiologists-and-urologists
#1
Matthew S Davenport, Eric M Hu, Andrew D Smith, Hersh Chandarana, Khaled Hafez, Ganesh S Palapattu, J Stuart Wolf, Stuart G Silverman
PURPOSE: To define important elements of a structured radiology report of a CT or MRI performed to evaluate an indeterminate renal mass. METHODS: IRB approval was waived for this multi-site prospective quality improvement study. A 35-question survey investigating elements of a CT or MRI report describing a renal mass was created through an iterative process by the Society of Abdominal Radiology Disease-Focused Panel on renal cell carcinoma. Surveys were distributed to consenting abdominal radiologists and urologists at nine academic institutions...
November 22, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27867332/predictive-ability-of-preoperative-ct-scan-in-determining-whether-the-adrenal-gland-is-spared-at-radical-nephrectomy
#2
Gregory J Nason, Asadullah Aslam, Subhasis K Giri
INTRODUCTION: The aim of this study was to assess whether preoperative multiple detector computed tomography (MDCT) accurately predicts adrenal involvement for patients undergoing non-adrenal sparing radical nephrectomy for renal cell carcinoma. METHODS AND MATERIALS: A retrospective observational study based on a composite patient population of two university teaching hospitals who underwent radical nephrectomy. Sensitivity, specificity, overall accuracy, positive and negative predictive values and likelihood ratios were calculated from radiological reports...
October 2016: Current Urology
https://www.readbyqxmd.com/read/27857461/bolster-material-granuloma-masquerading-as-recurrent-renal-cell-carcinoma-following-partial-nephrectomy
#3
Abhishek Singh, Shrikant Jai, Sanika Ganpule, Arvind Ganpule
Nephron sparing surgery has seen a phenomenal rise in its application over the past few decades. The use of Surgicel and gel foam for closure of defect created after partial nephrectomy has become a routine practice at many centers. In this case report, we describe radiological artifact secondary to a surgical bolster mimicking a residual disease or an early recurrence in the kidney. This case highlights two facts; first, reapproximation of the renal tissue is best done without the use of Surgicel bolsters...
July 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27842541/heterogeneous-response-and-progression-patterns-reveal-phenotypic-heterogeneity-of-tyrosine-kinase-inhibitor-response-in-metastatic-renal-cell-carcinoma
#4
Shanthini M Crusz, Yen Zhi Tang, Shah-Jalal Sarker, Warner Prevoo, Irfan Kiyani, Luis Beltran, John Peters, Anju Sahdev, Axel Bex, Thomas Powles, Marco Gerlinger
BACKGROUND: Molecular intratumour heterogeneity (ITH) is common in clear cell renal carcinomas (ccRCCs). However, it remains unknown whether this is mirrored by heterogeneity of drug responses between metastases in the same patient. METHODS: We performed a retrospective central radiological analysis of patients with treatment-naïve metastatic ccRCC receiving anti-angiogenic tyrosine kinase inhibitors (TKIs) (sunitinib or pazopanib) within three similar phase II trials...
November 14, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27793960/u-s-food-and-drug-administration-approval-cabozantinib-for-treatment-of-advanced-renal-cell-carcinoma
#5
Harpreet Singh, Michael Brave, Julia A Beaver, Joyce Cheng, Shenghui Tang, Eias Zahalka, Todd R Palmby, Rajesh Venugopal, Pengfei Song, Qi Liu, Chao Liu, Jingyu Yu, Xiao Hong Chen, Xing Wang, Yaning Wang, Paul G Kluetz, Selena R Daniels, Elektra J Papadopoulos, Rajeshwari Sridhara, Amy E McKee, Amna Ibrahim, Geoffrey Kim, Richard Pazdur
On April 25, 2016, the U. S. Food and Drug Administration (FDA) approved cabozantinib (CABOMETYX{trade mark, serif}, Exelixis, Inc.) for the treatment of advanced renal cell carcinoma (RCC) in patients who have received prior anti-angiogenic therapy. The approval was based on data from one randomized, open-label, multicenter study in which RCC patients who had received prior anti-angiogenic therapy were treated with either cabozantinib 60 mg orally once daily (N=330) or everolimus 10 mg orally once daily (N=328)...
October 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27787547/adjuvant-weekly-girentuximab-following-nephrectomy-for-high-risk-renal-cell-carcinoma-the-ariser-randomized-clinical-trial
#6
Karim Chamie, Nicholas M Donin, Pia Klöpfer, Paul Bevan, Barbara Fall, Olaf Wilhelm, Stephan Störkel, Jonathan Said, Michael Gambla, Robert E Hawkins, Gustavo Jankilevich, Anil Kapoor, Evgeny Kopyltsov, Michael Staehler, Kimmo Taari, Alberto J A Wainstein, Allan J Pantuck, Arie S Belldegrun
Importance: Girentuximab is a chimeric monoclonal antibody that binds carbonic anhydrase IX, a cell surface glycoprotein ubiquitously expressed in clear cell renal cell carcinoma (ccRCC). Its safety and activity in phase 2 studies prompted investigation into its use as adjuvant monotherapy in participants with high-risk ccRCC. Objective: To evaluate the safety and efficacy of adjuvant girentuximab on disease-free survival (DFS) and overall survival (OS) in patients with localized completely resected high-risk ccRCC...
October 27, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27761149/endoscopic-ultrasound-guided-fine-needle-aspiration-cytology-of-metastatic-renal-cell-carcinoma-to-the-pancreas-a-multi-center-experience
#7
Rahul Pannala, Karyn M Hallberg-Wallace, Amber L Smith, Aziza Nassar, Jun Zhang, Matthew Zarka, Jordan P Reynolds, Longwen Chen
INTRODUCTION: The increasing use of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) cytology to examine pancreatic neoplasms has led to an increase in the diagnosis of metastases to the pancreas. Renal cell carcinoma (RCC) is the most common metastasis to the pancreas. Our study examines 33 cases of metastatic RCC to the pancreas sampled by EUS-FNA from four large tertiary care hospitals. MATERIALS AND METHODS: We searched the cytopathology database for RCC metastatic to the pancreas diagnosed by EUS-FNA from January 2005 to January 2015...
2016: CytoJournal
https://www.readbyqxmd.com/read/27737652/ct-guided-cryoablation-for-locally-recurrent-or-metastatic-bone-and-soft-tissue-tumor-initial-experience
#8
Michiro Susa, Kazutaka Kikuta, Robert Nakayama, Kazumasa Nishimoto, Keisuke Horiuchi, Sota Oguro, Masanori Inoue, Hideki Yashiro, Seishi Nakatsuka, Masaya Nakamura, Morio Matsumoto, Kazuhiro Chiba, Hideo Morioka
BACKGROUND: Historically, local control of recurrent sarcomas has been limited to radiotherapy when surgical re-resection is not feasible. For metastatic carcinomas to the bone or soft tissue, radiotherapy and some interventional radiology treatment along with other systemic therapies have been widely advocated due to the possibility of disseminated disease. These techniques are effective in alleviating pain and achieving local control for some tumor types, but it has not been effective for prolonged local control of most tumors...
October 13, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27729042/diagnostic-accuracy-of-contrast-enhanced-computed-tomography-and-contrast-enhanced-magnetic-resonance-imaging-of-small-renal-masses-in-real-practice-sensitivity-and-specificity-according-to-subjective-radiologic-interpretation
#9
Jae Heon Kim, Hwa Yeon Sun, Jiyoung Hwang, Seong Sook Hong, Yong Jin Cho, Seung Whan Doo, Won Jae Yang, Yun Seob Song
BACKGROUND: The aim of this study was to investigate the diagnostic accuracy of contrast-enhanced computed tomography (CT) and contrast-enhanced magnetic resonance imaging (MRI) of small renal masses in real practice. METHODS: Contrast-enhanced CT and MRI were performed between February 2008 and February 2013 on 68 patients who had suspected small (≤4 cm) renal cell carcinoma (RCC) based on ultrasonographic measurements. CT and MRI radiographs were reviewed, and the findings of small renal masses were re-categorized into five dichotomized scales by the same two radiologists who had interpreted the original images...
October 12, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27721288/xanthogranulomatous-pyelonephritis-and-renal-tubulopapillary-adenomas-a-rare-coexistence
#10
Deval Parekh, Moumita Sengupta, Mou Das, Uttara Chatterjee
Xanthogranulomatous pyelonephritis is an uncommon inflammatory condition accounting for 1% of chronic pyelonephritis cases. Clinically and radiologically it mimics other renal space occupying lesions. Hence, correct preoperative diagnosis is not possible in all cases and nephrectomy is done in most patients. Renal tubulopapillary adenomas are benign epithelial lesions of kidney found to be associated with papillary renal cell carcinoma, acquired renal cystic disease, long term hemodialysis, arteriosclerotic renal vascular disease, etc...
October 2016: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/27720441/aetiology-imaging-features-and-evolution-of-spontaneous-perirenal-haemorrhage
#11
Y Mao, I S De Oliveira, S Hedgire, D Prapruttam, M Harisinghani
AIM: To evaluate the aetiology, imaging features, and the evolution of spontaneous perirenal haemorrhage detected by imaging. MATERIALS AND METHODS: In this retrospective study, the hospital database was searched for all cases of spontaneous perinephric haemorrhage detected by imaging between January 2000 and December 2012. Imaging examinations were reviewed and the following parameters were recorded: the location, extension, and total volume of the haematoma, presence of active extravasation, the haematocrit effect, and highest density...
October 6, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27684070/morphological-characterization-of-papillary-renal-cell-carcinoma-type-1-the-efficiency-of-its-surgical-treatment
#12
Kristýna Procházková, Michael Staehler, Ivan Trávníček, Tomáš Pitra, Viktor Eret, Tomáš Ürge, Lada Eberlová, Milena Roušarová, Petr Hošek, Zdeněk Chudáček, Jiří Ferda, Ondřej Hes, Milan Hora
AIM: Papillary renal cell carcinoma type 1 (pRCC1) represents the second most common type of malignant renal epithelial tumour. The origin of its characteristic appearance, its growth mechanism, and the long-term efficiency of its surgical treatment remain uncertain. Our aim was to determine typical characteristics of surgically treated pRCC1. METHODS: pRCC1 was verified in 83 of 1,629 (5.1%) kidney tumours surgically treated in the period of January 2007-January 2016...
September 30, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27642438/-renal-epithelioid-angiomyolipoma-mimicking-renal-carcinoma
#13
Hanen Bouaziz, Ramzi Khiari, Mohamed Dridi, Samir Ghozzi, Nawfel Ben Rais
Epithelioid angiomyolipoma is a rare form of potentially malignant angiomyolipoma, recently considered separate entity by the World Health Organization classification of renal tumors. This lesion poses a problem in differential diagnosis with clear cell carcinomas. There are no clinical or radiological specific criteria that characterize this tumor. Immunohistochemistry revealing epithelioid cells with positive HMB45 marker is essential for diagnosis. Treatment should be discussed during the multidisciplinary consultation...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27635298/pseudotumor-presentation-of-renal-tuberculosis-mimicking-renal-cell-carcinoma-a-rare-entity
#14
Anubhav Panwar, Raju Ranjan, Nityasha Drall, Neha Mishra
Tuberculosis can involve any part of the body. Urogenital tuberculosis is a fairly common extra-pulmonary manifestation of tuberculosis and renal tuberculosis is the most common form of urogenital tuberculosis. Renal tuberculosis seldom presents as a mass, usually due to hydronephrosis of the involved kidney. However in extremely rare cases it may present as an inflammatory pseudotumor which may mimic renal cell carcinoma. We present a case of a 65- year- old male who was provisionally diagnosed as renal cell carcinoma based on clinical and radiological findings and managed accordingly but was finally diagnosed as renal tuberculosis based on histopathological examination of surgical specimen...
September 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27601819/metastatic-lesions-a-diagnostic-dilemma-retrospective-study-srinagar-jammu-and-kashmir-india
#15
Summyia Farooq, Afreen Nadaf, Ambreen Beigh, Mehnaaz Khuroo, Nazia Bhat, Naila Nazir
BACKGROUND: Renal clear cell carcinoma (RCC) accounts for about 3% of adult malignancies and about 90% of neoplasms of the kidney. It is most common in men aged 50 to 60 years old. RCC has different manifestations, including metastasis in uncommon sites and paraneoplastic syndromes. AIMS: To evaluate the clinicopathological pattern of RCC. MATERIALS AND METHODS: This study was conducted in the Department of Pathology, Government Medical College, Srinagar...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27594948/upper-extremity-tumor-embolization-using-a-transradial-artery-approach-technical-note
#16
Taryar Zaw, Jason C Ni, Jonathan K Park, Matthew Walsworth
Transradial access is being used with increasing frequency for interventional radiology procedures and offers several key advantages, including decreased access site complications and increased patient comfort. We report the technique of using transradial access to perform preoperative embolization of a humeral renal cell carcinoma metastasis and pathologic fracture. A transradial approach for performing humeral preoperative tumor embolization has not been previously reported, to our knowledge. In the appropriately selected patient, this approach may be safely used to perform upper extremity embolization...
September 2016: Radiology case reports
https://www.readbyqxmd.com/read/27494939/oncocytic-papillary-renal-cell-carcinoma-in-the-background-of-renal-adenomatosis-a-case-report
#17
Ji Yeon Kim
Renal adenomatosis is a rare disease characterized by numerous adenomas in bilateral kidneys. A literature review shows that malignant tumors can arise in this condition. The present case describes an oncocytic papillary renal cell carcinoma (PRCC) arising in renal adenomatosis. A 70-year-old man presented with incidentally identified, multiple right renal masses on computed tomography. Right nephrectomy was performed, and the resected kidney revealed numerous radiologically undetected small nodules additionally...
August 5, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27453653/radiologic-indicators-prior-to-renal-cell-cancer-thrombectomy-implications-for-vascular-reconstruction-and-mortality
#18
Stephen Overholser, Omer Raheem, David Zapata, Dharam Kaushik, Ronald Rodriguez, Ithaar H Derweesh, Michael A Liss
BACKGROUND: Renal cancer may invade the inferior vena cava (IVC) creating more complex surgical intervention. We investigate radiologic findings that may predict vascular reconstruction prior to surgery and future renal cancer-specific mortality. MATERIALS AND METHODS: Radiologic findings included Mayo Clinic risk factors for vascular reconstruction: Right-sided tumor, anteroposterior diameter of the IVC at the ostium of the renal vein ≥24.0 mm, and radiologic identification of complete occlusion of the IVC...
July 2016: Urology Annals
https://www.readbyqxmd.com/read/27436926/recurrent-renal-giant-leiomyosarcoma
#19
Salih Erpulat Öziş, Kamil Gülpınar, Zafer Şahlı, Baha Burak Konak, Mete Keskin, Süleyman Özdemir, Ömür Ataoğlu
Primary renal leiomyosarcomas are rare, aggressive tumors. They constitute 1-2% of adult malignant renal tumors. Although leiomyosarcomas are the most common histological type (50-60%) of renal sarcomas, information on renal leiomyosarcoma is limited. Local or systemic recurrences are common. The radiological appearance of renal leiomyosarcomas is not specific, therefore renal leiomyosarcoma cannot be distinguished from renal cell carcinoma by imaging methods in all patients. A 74-year-old female patient presented to our clinic complaining of a palpable mass on the right side of her abdomen in November 2012...
2016: Ulusal Cerrahi Dergisi
https://www.readbyqxmd.com/read/27420728/severe-perioperative-bleeding-in-renal-cell-carcinoma-after-elective-pericardiocentesis-associated-left-ventricular-puncture-case-report
#20
Javier Lasala, Miguel Alejandro Patino, Gabriel Mena, Shital Vachhani, Teresa Moon, Thao Bui, January Tsai
In the United States during the year 2015, approximately 61,560 patients are expected to be diagnosed with kidney cancer and 14,080 to die from the disease. We present the case of a patient with renal cell carcinoma who suffered severe perioperative bleeding and coagulopathy after emergency sternotomy. We also engage in relevant aspects of perioperative anesthesia care including the considerations and management of coagulopathy, liver failure and renal failure in the oncologic patient. The case is a 49-year-old man with vena cava tumor thrombus who underwent radiologic tumor embolization, left radical nephrectomy, and inferior vena cava (IVC) thrombectomy...
2016: Medwave
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