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https://www.readbyqxmd.com/read/29793188/prioritization-of-reproductive-toxicants-in-unconventional-oil-and-gas-operations-using-a-multi-country-regulatory-data-driven-hazard-assessment
#1
Salmaan H Inayat-Hussain, Masao Fukumura, A Muiz Aziz, Chai Meng Jin, Low Wei Jin, Rolando Garcia-Milian, Vasilis Vasiliou, Nicole C Deziel
BACKGROUND: Recent trends have witnessed the global growth of unconventional oil and gas (UOG) production. Epidemiologic studies have suggested associations between proximity to UOG operations with increased adverse birth outcomes and cancer, though specific potential etiologic agents have not yet been identified. To perform effective risk assessment of chemicals used in UOG production, the first step of hazard identification followed by prioritization specifically for reproductive toxicity, carcinogenicity and mutagenicity is crucial in an evidence-based risk assessment approach...
May 21, 2018: Environment International
https://www.readbyqxmd.com/read/29790188/coagulation-failure-in-patients-with-acute-on-chronic-liver-failure-aclf-and-decompensated-cirrhosis-beyond-inr
#2
Annabel Blasi, Andrea Calvo, Verónica Prado, Enric Reverter, Juan Carlos Reverter, María Hernández-Tejero, Fátima Aziz, Alex Amoros, Andres Cardenas, Javier Fernández
Balanced hemostasis with hypo and hypercoagulable features may occur in acute-on-chronic liver failure. Characteristics and prognostic impact of the coagulation profile in acute-on-chronic liver failure are unknown. METHODS: Consecutive patients with acute-on-chronic liver failure (n=36) and acute decompensation (n=24) were included. Blood samples for thromboelastometry (ROTEM®) were obtained at admission and 72h thereafter. Coagulation profile was evaluated in patients with and without acute-on-chronic liver failure and in those with and without systemic inflammatory response syndrome...
May 23, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29790124/colorectal-cancer-why-does-side-matter
#3
Claire Gallois, Simon Pernot, Aziz Zaanan, Julien Taieb
Colorectal cancer (CRC) is a heterogeneous disease, and the search for clinical and molecular prognostic and predictive factors is thus necessary to better tailor each individual patient's management. Primary tumor location (PTL) seems to act as a master prognostic factor pooling different clinical, pathological, and molecular poor prognostic factors. In fact, right-sided (RS) CRC patients are more frequently female and elderly with microsatellite unstable, BRAF mutated, CpG island methylator phenotype (CIMP)-high, poorly differentiated tumors, compared to left-sided (LS) CRC patients...
May 22, 2018: Drugs
https://www.readbyqxmd.com/read/29788758/synthesis-and-biological-evaluation-of-2-aminothiazole-thiazolidinone-conjugates-as-potential-antitubercular-agents
#4
Mahmoud F Abo-Ashour, Wagdy M Eldehna, Riham F George, Marwa M Abdel-Aziz, Mahmoud M Elaasser, Sahar M Abou-Seri, Nagwa M Abdel Gawad
AIM: Mycobacterium tuberculosis, which causes tuberculosis, continues to infect millions of the global population, resulting in 1.8 million deaths worldwide in 2015. METHODOLOGY: Hybrids of 2-amino-4-methylthiazole bearing 5-acetyl/5-ethyl carboxylate functionality with 5-arylidene thiazolidinone moiety (6a-k and 9a-d) were synthesized and screened for antitubercular and antimicrobial activities. RESULTS & DISCUSSION: 5-ethyl carboxylate derivative 6k revealed half antitubercular activity (minimal inhibitory concentration = 1...
May 23, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29782897/metal-concentrations-in-fillet-and-gill-of-parrotfish-scarus-ghobban-from-the-persian-gulf-and-implications-for-human-health
#5
Yadolah Fakhri, Narottam Saha, Ali Miri, Aziz Rahimizadeh, Laleh Roomiani, Mansour Ghaderpoori, Mahmoud Taghavi, Hassan Keramati, Zohreh Bahmani, Bigard Moradi, Nazak Amanidaz
Despite the benefits of seafood's consumption, the bioaccumulation of metals in fish can endanger consumers' health. This study analyzed lead (Pb), mercury (Hg), Arsenic (As), and Cadmium (Cd) concentrations in fillet and gill of parrotfish (Scarus ghobban) using flame atomic adsorption spectroscopy (FAAS). The potential non-carcinogenic and carcinogenic health risks due to consumption of Scarus ghobban fillet were assessed by estimating average target hazard quotient (THQ) and total target hazard quotient (TTHQ) and Incremental Lifetime Cancer Risk cancer risk (ILCR) of the analyzed metals...
May 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29782201/positional-and-dimensional-temporomandibular-joint-changes-after-correction-of-posterior-crossbite-in-growing-patients-a-systematic-review
#6
Mohamed T Ellabban, Ahmed I Abdul-Aziz, Mona M Salah Fayed, Mai H AboulFotouh, Ehab S Elkattan, Mushira M Dahaba
OBJECTIVE: To elucidate the positional and dimensional temporomandibular joint (TMJ) changes after correction of posterior crossbite in growing patients. MATERIALS AND METHODS: A systematic unrestricted search was done in six databases until June 27, 2017. A manual search in the reference lists of the included studies and gray literature was also performed. The eligibility criteria included randomized controlled trials and prospective nonrandomized controlled clinical trials and a sample of growing subjects with posterior crossbite that required maxillary expansion...
May 22, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29781978/mixed-methods-evaluation-of-real-time-safety-reporting-by-hospitalized-patients-and-their-care-partners-the-mysafecare-application
#7
Sarah A Collins, Brittany Couture, Ann DeBord Smith, Esteban Gershanik, Elizabeth Lilley, Frank Chang, Cathy Yoon, Stuart Lipsitz, Aziz Sheikh, James Benneyan, David W Bates
OBJECTIVE: The aims of the study were to evaluate the amount and content of data patients and care partners reported using a real-time electronic safety tool compared with other reporting mechanisms and to understand their perspectives on safety concerns and reporting in the hospital. METHODS: This study used mixed methods including 20-month preimplementation and postimplementation trial evaluating MySafeCare, a web-based application, which allows hospitalized patients/care partners to report safety concerns in real time...
April 27, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29780034/improving-predictive-asthma-algorithms-with-modelled-environment-data-for-scotland-an-observational-cohort-study-protocol
#8
Ireneous N Soyiri, Aziz Sheikh, Stefan Reis, Kimberly Kavanagh, Massimo Vieno, Tom Clemens, Edward J Carnell, Jiafeng Pan, Abby King, Rachel C Beck, Hester J T Ward, Chris Dibben, Chris Robertson, Colin R Simpson
INTRODUCTION: Asthma has a considerable, but potentially, avoidable burden on many populations globally. Scotland has some of the poorest health outcomes from asthma. Although ambient pollution, weather changes and sociodemographic factors have been associated with asthma attacks, it remains unclear whether modelled environment data and geospatial information can improve population-based asthma predictive algorithms. We aim to create the afferent loop of a national learning health system for asthma in Scotland...
May 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29777814/effect-of-vinyl-montmorillonite-on-the-physical-responsive-and-antimicrobial-properties-of-the-optimized-polyacrylic-acid-chitosan-superabsorbent-via-box-behnken-model
#9
Mohamed S Abdel Aziz, Hend E Salama
This work aims to study the effect of a vinyl-modified montmorillonite (VMT) on the physical and antimicrobial properties of chitosan-graft-polyacrylic acid superabsorbent (Ch-g-PA). Ch-g-PA was first optimized using Box-Behnken Design to obtain the maximum equilibrium swelling, and the model was efficient to express the experimental swelling data (R2  = 0.999). VMT was further added to the optimized Ch-g-PA in different contents 0, 4, 7 and 10 wt%. FTIR confirmed the successful synthesis of the copolymers and their nanocomposites...
May 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29777495/ameliorative-effect-of-ginseng-extract-on-phthalate-and-bisphenol-a-reprotoxicity-during-pregnancy-in-rats
#10
Islam M Saadeldin, Mohamed A Hussein, Aida Hamid Suleiman, Mahmoud G Abohassan, Mona M Ahmed, Amr A Moustafa, Abdullah F Moumen, Ayman Abdel-Aziz Swelum
Phthalates (such as DEHP) and bisphenol A (BPA) are widely used chemicals in plastics manufacturing and exert public health concerns as endocrine disrupters. This study was designed to investigate the deleterious effect of DEHP and BPA on endocrine profile of pregnant female rats and the combined treatment with ginseng extract (Panax ginseng). Seventy-two pregnant rats were divided into six groups (control, ginseng, DEHP, BPA, Gin + DEHP, and Gin + BPA), 12 females per each group. The drugs were supplemented from pregnancy day 0 until day 20...
May 18, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29776782/an-intervention-to-increase-students-physical-activity-a-2-year-pilot-study
#11
R Glenn Weaver, Collin A Webster, Michael W Beets, Keith Brazendale, Lauren Schisler, Mazen Aziz
INTRODUCTION: Schools are called upon to provide children with 30 minutes/day of moderate to vigorous physical activity (MVPA). Most school-based physical activity interventions have not targeted schools that serve children from low-income families. This study evaluated the effects of a pilot, competency-building professional development program on the school day MVPA and total activity (light- to vigorous-intensity activity) of students from schools that serve low-income families. STUDY DESIGN: Single group intervention with multiple follow-up repeated cross-sectional measures...
May 15, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29773079/effects-of-linagliptin-on-endothelial-function-and-postprandial-lipids-in-coronary-artery-disease-patients-with-early-diabetes-a-randomized-placebo-controlled-double-blind-trial
#12
Norbert J Tripolt, Felix Aberer, Regina Riedl, Jasmin Url, Gudrun Dimsity, Andreas Meinitzer, Tatjana Stojakovic, Faisal Aziz, Ronald Hödl, Gabriele Brachtl, Dirk Strunk, Marianne Brodmann, Franz Hafner, Harald Sourij
BACKGROUND: Early glucose lowering intervention in subjects with type 2 diabetes mellitus was demonstrated to be beneficial in terms of micro- and macrovascular risk reduction. However, most of currently ongoing cardiovascular outcome trials are performed in subjects with manifest atherosclerosis and long-standing diabetes. Therefore, the aim of this study is to investigate the effects of the dipeptidylpeptidase-4 inhibitor linagliptin in subjects with coronary artery disease (CAD) but early type 2 diabetes mellitus (T2DM) on a set of cardiovascular surrogate measurements...
May 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29772111/clomiphene-citrate-and-human-chorionic-gonadotropin-are-both-effective-in-restoring-testosterone-in-hypogonadism-a-short-course-randomised-study
#13
Mohamad Habous, Simone Giona, Alaa Tealab, Mohammed Aziz, Ben Williamson, Mohammed Nassar, Zeyad Abdelrahman, Abdallah Remeah, Mohamed Abdelkader, Saleh Binsaleh, Gordon Muir
OBJECTIVES: To compare serum testosterone response and symptom improvement in hypogonadal men in response to treatment by one of three options: clomiphene citrate(CC), human chorionic gonadotropin (hCG), or combination of both therapy. PATIENTS AND METHODS: 282 hypogonadal adult, willing to preserve their fertility, were randomised in three arms treated respectively with: 50 mg of (CC) (n=95), 5000IU of hCG injections twice a week(n=94) or combination of both therapy(n=94)...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29771977/studying-the-dynamics-of-interbeat-interval-time-series-of-healthy-and-congestive-heart-failure-subjects-using-scale-based-symbolic-entropy-analysis
#14
Imtiaz Awan, Wajid Aziz, Imran Hussain Shah, Nazneen Habib, Jalal S Alowibdi, Sharjil Saeed, Malik Sajjad Ahmed Nadeem, Syed Ahsin Ali Shah
Considerable interest has been devoted for developing a deeper understanding of the dynamics of healthy biological systems and how these dynamics are affected due to aging and disease. Entropy based complexity measures have widely been used for quantifying the dynamics of physical and biological systems. These techniques have provided valuable information leading to a fuller understanding of the dynamics of these systems and underlying stimuli that are responsible for anomalous behavior. The single scale based traditional entropy measures yielded contradictory results about the dynamics of real world time series data of healthy and pathological subjects...
2018: PloS One
https://www.readbyqxmd.com/read/29771808/predicting-survival-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-appendix-adenocarcinoma
#15
Omer Aziz, Ihab Jaradat, Bipasha Chakrabarty, Chelliah R Selvasekar, Paul E Fulford, Mark P Saunders, Andrew G Renehan, Malcolm S Wilson, Sarah T O'Dwyer
BACKGROUND: Appendix adenocarcinomas are rare tumors with propensity for peritoneal metastasis. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy is an established treatment with curative intent, but, to date, studies reporting survival have been heterogeneous with regard to their patient groups (including other tumor types), interventions (not all patients receiving intraperitoneal chemotherapy), and follow-up (varying surveillance protocols). OBJECTIVE: The aim of this study is to quantify the impact of this intervention on survival in a homogeneous group of patients with appendix adenocarcinoma receiving standardized treatment and follow-up, and to determine the impact of prognostic indicators on survival...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29771390/children-learning-about-second-hand-smoke-class-ii-a-pilot-cluster-randomised-controlled-trial
#16
Kamran Siddiqi, Rumana Huque, Mona Kanaan, Farid Ahmed, Tarana Ferdous, Sarwat Shah, Cath Jackson, Steve Parrott, Jasjit S Ahluwalia, Aziz Sheikh
Introduction: Children exposed to second-hand smoke (SHS) are at increased risk of respiratory illnesses. We piloted a Smoke Free Intervention (SFI) and trial methods before investigating its effectiveness and cost-effectiveness in primary school children. Methods: In a pilot cluster randomised controlled-trial in Bangladesh, primary schools were allocated to usual education (control) or SFI, using minimisation. Year-5 children were recruited. Masking treatment allocation was not possible...
May 16, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29770962/factors-influencing-arab-nursing-students-attitudes-toward-climate-change-and-environmental-sustainability-and-their-inclusion-in-nursing-curricula
#17
Jonas Preposi Cruz, Rhea Faye D Felicilda-Reynaldo, Farhan Alshammari, Nahed Alquwez, Jerico G Alicante, Khamees B Obaid, Hanan Ebrahim Abd El Aziz Rady, Mohammad Qtait, John Paul Ben T Silang
OBJECTIVE: To assess the factors influencing the attitudes of Bachelor of Science in Nursing students toward climate change and environmental sustainability and the inclusion of these concepts in the nursing curricula of four Arab countries. METHOD: A convenience sample of 1,059 students from four Arab countries was surveyed using the Environmental Sustainability Attitudes in Nursing Survey-2 (SANS-2) questionnaire in this descriptive-comparative study. RESULTS: The majority of the respondents exhibited positive attitudes toward the five items of SANS-2, with "Environmental sustainability is an important issue for nursing" receiving the lowest mean score and "Issues about climate change should be included in the nursing curriculum" receiving the highest mean score...
May 17, 2018: Public Health Nursing
https://www.readbyqxmd.com/read/29769513/ovarian-endometrioid-adenocarcinoma-arising-in-endometriosis-a-case-report
#18
K Nahar, B Ferdous, N Akhter, P A Shamsunnahar, K Khatun, S A Begum, M A Aziz
Malignant transformation of ovarian endometriosis was first described in 1925 by Sampson; later on it has been described in extragonadal regions by few authors also. Ovarian endometrioid and clear cell carcinoma are highly associated with endometriosis. Here we present a case of malignant transformation of ovarian endometrioma into endometrioid adenocarcinoma and review the clinical and pathological features of these tumors. A 45-years old infertile woman diagnosed as a case of bilateral chocolate cyst with pelvic endometriosis underwent total hysterectomy with bilateral salpingo-oophorectomy...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29768057/nocebo-effects-more-investigation-is-needed
#19
Fabrizio Benedetti, Aziz Shaibani
No abstract text is available yet for this article.
May 16, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29767960/comparison-of-alicyclobacillus-acidocaldarius-osbs-to-its-promiscuous-nsar-osbs-relatives
#20
Denis Odokonyero, Andrew W McMillan, Udupi A Ramagopal, Rafael Toro, Dat P Truong, Mingzhao Zhu, Mariana S Lopez, Belema Somiari, Meghann Herman, Asma Aziz, Jeffrey B Bonanno, Kenneth G Hull, Stephen K Burley, Daniel Romo, Steven C Almo, Margaret E Glasner
Studying the evolution of catalytically promiscuous enzymes like those from the N-succinylamino acid racemase/ o-succinylbenzoate synthase (NSAR/OSBS) subfamily can reveal mechanisms by which new functions evolve. Some enzymes in this subfamily only have OSBS activity, while others catalyze OSBS and NSAR reactions. We characterized several NSAR/OSBS subfamily enzymes as a step toward determining the structural basis for evolving NSAR activity. Three enzymes were promiscuous, like most other characterized NSAR/OSBS subfamily enzymes...
May 16, 2018: Biochemistry
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