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https://www.readbyqxmd.com/read/29345503/effectiveness-of-the-biophysical-barriers-to-the-peridural-fibrosis-in-rat-laminectomy-model
#1
Ibrahim Akkurt, Bulent Bakar, Gungor Cagdas Dincel, Fatma Azize Budak Yıldıran, Mustafa Ogden, Egemen Nursoy, Elif Sari
PURPOSE: Peridural fibrosis which could occur after the spinal surgery could adhere neural tissue closely and may cause to neural entrapment symptoms and require surgical reintervention. AIM OF THE STUDY: Present study was designed to reduce occurrence of peridural fibrosis in rat laminectomy model by using biophysical barriers called hyaluronic acid (HAS) dural barrier, activated polyethylene glycol and polyethylene imine (PEG) dural barrier, and platelet-rich plasma (PRP)...
January 18, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29345380/cirp-increases-icam-1-phenotype-of-neutrophils-exhibiting-elevated-inos-and-nets-in-sepsis
#2
Yasumasa Ode, Monowar Aziz, Ping Wang
Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for the development and function of ICAM-1+ neutrophils during sepsis is unknown. We hypothesize that CIRP induces ICAM-1 expression in neutrophils causing injury to the lungs during sepsis. Using a mouse model of cecal ligation and puncture (CLP)-induced sepsis, we found increased expression of CIRP and higher frequencies and numbers of ICAM-1+ neutrophils in the lungs...
January 17, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29340302/localized-concentration-reversal-of-lithium-during-intercalation-into-nanoparticles
#3
Wei Zhang, Hui-Chia Yu, Lijun Wu, Hao Liu, Aziz Abdellahi, Bao Qiu, Jianming Bai, Bernardo Orvananos, Fiona C Strobridge, Xufeng Zhou, Zhaoping Liu, Gerbrand Ceder, Yimei Zhu, Katsuyo Thornton, Clare P Grey, Feng Wang
Nanoparticulate electrodes, such as Li x FePO4, have unique advantages over their microparticulate counterparts for the applications in Li-ion batteries because of the shortened diffusion path and access to nonequilibrium routes for fast Li incorporation, thus radically boosting power density of the electrodes. However, how Li intercalation occurs locally in a single nanoparticle of such materials remains unresolved because real-time observation at such a fine scale is still lacking. We report visualization of local Li intercalation via solid-solution transformation in individual Li x FePO4 nanoparticles, enabled by probing sub-angstrom changes in the lattice spacing in situ...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29339279/green-synthesis-of-antimicrobial-and-antitumor-n-n-n-trimethyl-chitosan-chloride-poly-acrylic-acid-silver-nanocomposites
#4
Mahmoud H Abu Elella, Riham R Mohamed, Marwa M Abdel-Aziz, Magdy W Sabaa
The present study is imported to solve two critical problems we face in our daily life which are microbial pollution and colon cancer. One pot green synthesis of a water soluble polyelectrolyte complex (PEC) between cationic polysaccharide as N,N,N-trimethyl chitosan chloride (TMC) and anionic polymer as poly (acrylic acid) (PAA) in presence of silver nanoparticles to yield (TMC/PAA/Ag) nanocomposites with different Ag weight ratios. Structure of TMC, PAA and TMC/PAA (PEC) were proved via different analysis tools...
January 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29339047/the-impact-of-semilateral-decubitus-position-on-the-dose-volume-parameters-of-the-heart-and-lung-for-left-sided-breast-cancer-patients-a-comparative-dosimetric-study
#5
Azza Helal, Mohamed Farouk, Sherief H Gamie, Mahran Abdo, Lila Mosa, Amr Abdul Aziz
PURPOSE: When treating breast cancer with radiation therapy, the impact of treatment position on heart and lung dose-volume parameters (DVPs) is largely dependent on the maximal heart distance (MHD) and central lung distance (CLD). We evaluate how much heart and lung sparing can be achieved using the semilateral decubitus (SLD) position without and with breath hold compared with the standard supine position for left-sided breast cancer patients. A secondary aim was to investigate the impact of MHD and CLD on heart and lung DVPs...
December 2, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29338338/sesbagrandiflorain-a-and-b-isolation-of-two-new-2-arylbenzofurans-from-the-stem-bark-of-sesbania-grandiflora
#6
Noviany Noviany, Arif Nurhidayat, Sutopo Hadi, Tati Suhartati, Muhammad Aziz, Neny Purwitasari, Iman Subasman
Native to tropical Asia, Sesbania grandiflora (L.), Pers is a member of the Fabaceae family of flowering plants. All parts of S. grandiflora are used in traditional medicine and phytochemical investigations have been conducted on extracts of the leaves, seeds and roots of S. grandiflora to provide scientific validation of its properties. However, to date, no study has determined the phytochemical constituents of S. grandiflora stem bark. The stem bark powdered of S. grandiflora was extracted exhaustively with n-hexane, EtOAc and 90% aqueous MeOH sequentially...
January 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29334554/the-systemic-immune-inflammation-index-independently-predicts-survival-and-recurrence-in-resectable-pancreatic-cancer-and-its-prognostic-value-depends-on-bilirubin-levels-a-retrospective-multicenter-cohort-study
#7
Mohammad Hosein Aziz, Kostandinos Sideras, Nasir Ahmad Aziz, Katya Mauff, Roel Haen, Daphne Roos, Lawlaw Saida, Mustafa Suker, Erwin van der Harst, Jan Sven Mieog, Bert A Bonsing, Yarne Klaver, Bas Groot Koerkamp, Casper H van Eijck
OBJECTIVE: Our aim was to determine the prognostic significance of the systemic-immune-inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific survival as the primary outcome. BACKGROUND: Pancreatic cancer is associated with a dysfunctional immune system and poor prognosis. We examined the prognostic significance of the SIII in patients with resectable pancreatic ductal adenocarcinoma (PDAC) and the effects of bilirubin on this index...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29333572/possible-protective-effect-of-the-algae-spirulina-against-nephrotoxicity-induced-by-cyclosporine-a-and-or-gamma-radiation-in-rats
#8
Maha M Aziz, Nihad I Eid, Ahmed S Nada, Nour El-Din Amin, Afaf A Ain-Shoka
The present study was conducted to evaluate the possible protective role of the algae spirulina (Sp) against nephrotoxicity and oxidative stress which are the main secondary effects induced by the immunosuppressant drug CSA and/or ionizing radiation. In this study, male rats were given Sp (1 g/kg) either for 15 days before irradiation (6.5 Gy) or 5 days before and 10 days concomitant with CSA (25 mg/kg). Markers used to assess renal injury included serum creatinine, urea, glucose, albumin, protein, and lipid profile as well as kidney content of reduced glutathione (GSH); lipid peroxidation (thiobarbituric acid reactive substances (TBARS)); nitrite and superoxide dismutase (SOD) activity...
January 15, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29333015/a-profile-of-pediatric-solid-tumors-a-single-institution-experience-in-kashmir
#9
Namita Sharma, Ayesha Ahmad, Gull M Bhat, Sheikh A Aziz, Mohammad Maqbool Lone, Nisar A Bhat
Aims: The purpose of this retroprospective study was to study the epidemiological characteristics and outcomes of children with solid tumors at our institution. Subjects and Methods: Three hundred and three pediatrics patients registered at Regional Cancer Centre (RCC), Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, between January 2008 and June 2014, were analyzed with regard to demographic status, presenting complaints, investigations, treatment, morbidity, and outcomes...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29333008/metabolic-syndrome-and-breast-cancer-risk
#10
Burhan Wani, Shiekh Aejaz Aziz, Mohammad Ashraf Ganaie, Mohammad Hussain Mir
Objective: The study was meant to estimate the prevalence of metabolic syndrome in patients with breast cancer and to establish its role as an independent risk factor on occurrence of breast cancer. Materials and Methods: Fifty women aged between 40 and 80 years with breast cancer and fifty controls of similar age were assessed for metabolic syndrome prevalence and breast cancer risk factors, including age at menarche, reproductive status, live births, breastfeeding, and family history of breast cancer, age at diagnosis of breast cancer, body mass index, and metabolic syndrome parameters...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332634/reports-of-wheezing-and-of-diagnosed-asthma-are-associated-with-impaired-social-functioning-secondary-analysis-of-the-cross-sectional-world-health-survey-data
#11
Adrian Loerbroks, Jos A Bosch, Aziz Sheikh, Shelby Yamamoto, Raphael M Herr
OBJECTIVE: We sought to investigate whether there are associations between asthma and social functioning in adults from Western and non-Western countries. METHODS: We analyzed data on individuals (94% aged 20+, 52% female) from 50 countries participating in the cross-sectional World Health Survey. We used information on self-reports of wheezing and an asthma diagnosis. Social functioning was defined by reports of severe or extreme difficulties related to personal relationships or participation in the community...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29331049/prenatal-maternal-psychosocial-stress-and-offspring-s-asthma-and-allergic-disease-a-systematic-review-and-meta-analysis
#12
Catherine Flanigan, Aziz Sheikh, Audrey DunnGalvin, Bronwyn K Brew, Catarina Almqvist, Bright I Nwaru
BACKGROUND: Prenatal maternal stress may influence offspring's atopic risk through sustained cortisol secretion resulting from activation of the hypothalamic-pituitary-axis (HPA), leading to Th2-biased cell differentiation in the fetus. We undertook a systematic review and meta-analysis investigating the relationship between prenatal maternal psychosocial stress and risk of asthma and allergy in the offspring. METHODS: We searched 11 electronic databases from 1960 to 2016, search the grey literature, and contacted experts in the field...
January 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29331045/the-urgent-need-for-a-harmonized-severity-scoring-system-for-acute-allergic-reactions
#13
Antonella Muraro, Montserrat Fernandez-Rivas, Kirsten Beyer, Victòria Cardona, Andrew Clark, Esben Eller, Jonathan O'B Hourihane, Marek Jutel, Aziz Sheikh, Ioana Agache, Katrina J Allen, Liz Angier, Barbara Ballmer-Weber, Maria Beatrice Bilò, Carsten Bindslev-Jensen, Carlos A Camargo, Antonella Cianferoni, Audrey DunnGalvin, Philippe A Eigenmann, Susanne Halken, Karin Hoffmann-Sommergruber, Susanne Lau, Caroline Nilsson, Lars K Poulsen, Franziska Rueff, Jonathan Spergel, Gunter Sturm, Frans Timmermans, Maria J Torres, Paul Turner, Ronald van Ree, Magnus Wickman, Margitta Worm, E N Clare Mills, Graham Roberts
The accurate assessment and communication of the severity of acute allergic reactions is important to patients, clinicians, researchers, the food industry, public health and regulatory authorities. Severity has different meanings to different stakeholders with patients and clinicians rating the significance of particular symptoms very differently. Many severity scoring systems have been generated, most focusing on the severity of reactions following exposure to a limited group of allergens. They are heterogeneous in format, none has used an accepted developmental approach and none has been validated...
January 13, 2018: Allergy
https://www.readbyqxmd.com/read/29329342/ternary-copper-ii-complex-nci60-screening-toxicity-studies-and-evaluation-of-efficacy-in-xenograft-models-of-nasopharyngeal-carcinoma
#14
Munirah Ahmad, Shazlan-Noor Suhaimi, Tai-Lin Chu, Norazlin Abdul Aziz, Noor-Kaslina Mohd Kornain, D S Samiulla, Kwok-Wai Lo, Chew-Hee Ng, Alan Soo-Beng Khoo
Copper(II) ternary complex, [Cu(phen)(C-dmg)(H2O)]NO3 was evaluated against a panel of cell lines, tested for in vivo efficacy in nasopharyngeal carcinoma xenograft models as well as for toxicity in NOD scid gamma mice. The Cu(II) complex displayed broad spectrum cytotoxicity against multiple cancer types, including lung, colon, central nervous system, melanoma, ovarian, and prostate cancer cell lines in the NCI-60 panel. The Cu(II) complex did not cause significant induction of cytochrome P450 (CYP) 3A and 1A enzymes but moderately inhibited CYP isoforms 1A2, 2C9, 2C19, 2D6, 2B6, 2C8 and 3A4...
2018: PloS One
https://www.readbyqxmd.com/read/29328522/cassava-flour-slurry-as-a-low-cost-alternative-to-commercially-available-gel-for-obstetrical-ultrasound-a-blinded-non-inferiority-trial-comparison-of-image-quality
#15
Aleha Aziz, Pe'er Dar, Francine Hughes, Clemencia Solorzano, Mundenga Mutendi Muller, Christian Salmon, Margaret Salmon, Nerys Benfield
OBJECTIVE: To evaluate the quality of ultrasound images obtained with cassava flour slurry (CFS) compared to conventional gel in order to determine objectively whether CFS could be a true low-cost alternative. DESIGN: Blinded non-inferiority trial. SETTING: Obstetrical ultrasound unit in an academic medical center. POPULATION OR SAMPLE: Women with a singleton pregnancy, undergoing anatomy ultrasounds. METHODS: Thirty pregnant women had standard biometry measures obtained with CFS and conventional gel...
January 12, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29326201/eight-genome-sequences-of-cluster-be1-phages-that-infect-streptomyces-species
#16
Lee E Hughes, Christopher D Shaffer, Vassie C Ware, Issac Aguayo, Rahat M Aziz, Swapan Bhuiyan, Isaac S Bindert, Canyon K Calovich-Benne, Jordyn Chapman, Richard Donegan-Quick, Amal Farooq, Cynthia Garcia, Lee H Graham, Baylee Y Green, Margaret A Kenna, Emily R Kneeream, Christian E Laing, Catherine M Mageeney, Sandra N Meridew, Abigail R Mikolon, Ryann E Morgan, Subhayu Nayek, Idowu D Olugbade, Kim C Pike, Lauren E Schlegel, Taylor C Shishido, Tara Suresh, Nikita Suri, Kathleen Weston Hafer, Rebecca A Garlena, Daniel A Russell, Steven G Cresawn, Welkin H Pope, Deborah Jacobs-Sera, Graham F Hatfull
Cluster BE1 Streptomyces bacteriophages belong to the Siphoviridae, with genome sizes over 130 kbp, and they contain direct terminal repeats of approximately 11 kbp. Eight newly isolated closely related cluster BE1 phages contain 43 to 48 tRNAs, one transfer-messenger RNA (tmRNA), and 216 to 236 predicted open reading frames (ORFs), but few of their genes are shared with other phages, including those infecting Streptomyces species.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29325639/pediatric-brugada-syndrome-avoiding-the-inappropriate-icd
#17
EDITORIAL
Peter F Aziz
No abstract text is available yet for this article.
January 16, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29324483/advancing-patient-safety-in-airway-management
#18
Michael F Aziz
No abstract text is available yet for this article.
January 12, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29321554/mutations-in-dnmt3a-u2af1-and-ezh2-identify-intermediate-risk-acute-myeloid-leukemia-patients-with-poor-outcome-after-cr1
#19
Caner Saygin, Cassandra Hirsch, Bartlomiej Przychodzen, Mikkael A Sekeres, Betty K Hamilton, Matt Kalaycio, Hetty E Carraway, Aaron T Gerds, Sudipto Mukherjee, Aziz Nazha, Ronald Sobecks, Christopher Goebel, Donna Abounader, Jaroslaw P Maciejewski, Anjali S Advani
Intermediate-risk acute myeloid leukemia (IR-AML) is a clinically heterogeneous disease, for which optimal post-remission therapy is debated. The utility of next-generation sequencing information in decision making for IR-AML has yet to be elucidated. We retrospectively studied 100 IR-AML patients, defined by European Leukemia Net classification, who had mutational information at diagnosis, received intensive chemotherapy and achieved complete remission (CR) at Cleveland Clinic (CC). The Cancer Genome Atlas (TCGA) data were used for validation...
January 10, 2018: Blood Cancer Journal
https://www.readbyqxmd.com/read/29319184/diagnostic-accuracy-risk-assessment-and-cost-effectiveness-of-component-resolved-diagnostics-for-food-allergy-a-systematic-review
#20
REVIEW
Javier Flores Kim, Nicola McCleary, Bright I Nwaru, Andrew Stoddart, Aziz Sheikh
BACKGROUND: Component-resolved diagnostics (CRD) are promising tools for diagnosing food allergy, offering the potential to determine specific phenotypes and to develop patient-tailored risk profiles. Nevertheless, the diagnostic accuracy of these tests varies across studies; thus, their clinical utility remains unclear. Therefore, we synthesized the evidence from studies investigating the diagnostic accuracy, risk assessment ability, and cost-effectiveness of CRD for food allergy. METHODS: We systematically searched 10 electronic databases and four clinical trial registries for studies published January 2000-February 2017...
January 10, 2018: Allergy
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