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https://www.readbyqxmd.com/read/29153388/-endometrial-osseous-metaplasia-a-case-report
#1
Mohammed Alorini, Moutaz Aziz, Alexis Gromez, Nicolas Piton, Jean-Christophe Sabourin
Endometrial osseous metaplasia (EOM) is a rare condition characterised by the presence of bone in the uterine cavity. Some patients with this condition present with secondary infertility due to the presence of a foreign body in the endometrium. We report a case of a 39-year-old woman who presented with secondary infertility due to EOM. EOM is a rare cause of infertility that can be easily managed by hysteroscopic removal of the bony fragments.
November 15, 2017: Annales de Pathologie
https://www.readbyqxmd.com/read/29153080/impact-of-social-media-for-the-hematologist-oncologist
#2
REVIEW
Nour Abuhadra, Navneet S Majhail, Aziz Nazha
In the era of modern communication, the physician and patient relationship has evolved to include an entirely new dimension-social media. This new dimension offers several opportunities for patient education, research and its dissemination, and professional development for health care providers; it can also serve as a platform for addressing important public health issues. However, these advantages come with challenges such as threats to patient and professional privacy. In this article, we dissect the benefits and drawbacks of this social evolution on the practicing hematologist-oncologist...
October 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/29152338/crystal-structure-of-methyl-z-2-z-3-methyl-2-e-1-r-4-methyl-cyclo-hex-3-en-1-yl-ethyl-idene-hydrazinyl-idene-4-oxo-thia-zolidin-5-yl-idene-acetate
#3
Mourad Fawzi, Aziz Auhmani, Moulay Youssef Ait Itto, Abdelkhalek Riahi, Sylviane Chevreux, El Mostafa Ketatni
The new title 4-thia-zolidinone derivative, C16H21N3O3S, was obtained from the cyclization reaction of 4-methyl-3-thio-semicarbazone and dimethyl acetyl-enedi-carboxyl-ate (DMAD). The cyclo-hexyl-idene ring has an envelope conformation with the stereogenic centre C atom as the flap. Its mean plane makes a dihedral angle of 56.23 (9)° with the thia-zolidine ring mean plane. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds forming chains propagating in the [001] direction. Within the chains there are offset π-π inter-actions between the thia-zolidine rings of inversion-related mol-ecules [centroid-centroid distance = 3...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29152168/pollination-by-the-locally-endangered-island-flying-fox-pteropus-hypomelanus-enhances-fruit-production-of-the-economically-important-durian-durio-zibethinus
#4
Sheema A Aziz, Gopalasamy R Clements, Kim R McConkey, Tuanjit Sritongchuay, Saifful Pathil, Muhammad Nur Hafizi Abu Yazid, Ahimsa Campos-Arceiz, Pierre-Michel Forget, Sara Bumrungsri
Fruit bats provide valuable pollination services to humans through a unique coevolutionary relationship with chiropterophilous plants. However, chiropterophily in the Old World and the pollination roles of large bats, such as flying foxes (Pteropus spp., Acerodon spp., Desmalopex spp.), are still poorly understood and require further elucidation. Efforts to protect these bats have been hampered by a lack of basic quantitative information on their role as ecosystem service providers. Here, we investigate the role of the locally endangered island flying fox Pteropus hypomelanus in the pollination ecology of durian (Durio zibethinus), an economically important crop in Southeast Asia...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29152049/indolylalkyltriphenylphosphonium-analogues-are-membrane-depolarizing-mycobactericidal-agents
#5
Ming Li, Samuel A Nyantakyi, Pooja Gopal, Dinah Binte Aziz, Thomas Dick, Mei-Lin Go
Agents that selectively target the mycobacterial membrane could potentially shorten treatment time for tuberculosis, reduce relapse, and curtail emergence of resistant strains. The lipophilicity and extensive charge-delocalized state of the triphenylphosphonium cation strongly favor accumulation within bacterial membranes. Here, we explored the antimycobacterial activities and membrane-targeting properties of indolylalkyltriphenylphosphonium analogues. The most active analogues preferentially inhibited growth of Mycobacterium tuberculosis H37Rv (MIC50 2-4 μM) and were bactericidal against Mycobacterium bovis BCG (MBC99 3 μM)...
November 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29147835/automatic-localization-of-the-left-ventricular-blood-pool-centroid-in-short-axis-cardiac-cine-mr-images
#6
Li Kuo Tan, Yih Miin Liew, Einly Lim, Yang Faridah Abdul Aziz, Kok Han Chee, Robert A McLaughlin
In this paper, we develop and validate an open source, fully automatic algorithm to localize the left ventricular (LV) blood pool centroid in short axis cardiac cine MR images, enabling follow-on automated LV segmentation algorithms. The algorithm comprises four steps: (i) quantify motion to determine an initial region of interest surrounding the heart, (ii) identify potential 2D objects of interest using an intensity-based segmentation, (iii) assess contraction/expansion, circularity, and proximity to lung tissue to score all objects of interest in terms of their likelihood of constituting part of the LV, and (iv) aggregate the objects into connected groups and construct the final LV blood pool volume and centroid...
November 17, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29147059/tetanus-in-adult-males-bugando-medical-centre-united-republic-of-tanzania
#7
Riaz Aziz, Robert N Peck, Samuel Kalluvya, Bernard Kenemo, Alphonce Chandika, Jennifer A Downs
Problem: In the United Republic of Tanzania, the incidence of non-neonatal circumcision-related tetanus is probably underreported. Approach: We analysed charts and extracted information on outcome and wound location for non-neonatal cases of tetanus admitted to the intensive care unit of Bugando Medical Centre between 2001 and 2016. Local setting: Bugando Medical Centre, which is one of four teaching referral hospitals in the United Republic of Tanzania, has a 13-bed intensive care unit that manages all admitted patients with tetanus...
November 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29144828/prognostic-impact-of-cd200-and-cd56-expression-in-pediatric-b-cell-acute-lymphoblastic-leukemia-patients
#8
Salah Aref, Emad Azmy, Kadry El-Bakry, Lobna Ibrahim, Sherin Abdel Aziz
This study aimed to determine the prognostic impact of CD200 and CD56 expression in pediatric B cell acute lymphoblastic leukemia (B-ALL) patients, both of which have been implicated in immune tolerance and previously suggested as independent risk factors. CD200 has a central role in immune tolerance that protects stem cells and other critical tissues from immune damage. The expression of CD200/CD56 in leukemic blasts were assessed in leukemic blasts before chemotherapy in 43 bone marrow (BM) and/or peripheral blood (PB) samples by flow cytometry...
November 16, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29143438/protective-effects-of-coenzyme-q10-nanoparticles-on-dichlorvos-induced-hepatotoxicity-and-mitochondrial-lysosomal-injury
#9
Aziz Eftekhari, Elham Ahmadian, Aida Azami, Mohammad Johari-Ahar, Mohammad Ali Eghbal
Development of biocompatible antioxidant nanoparticles for xenobiotic-induced liver disease treatment by oral or parenteral administration is of great interest in medicine. In the current study, we demonstrate the protective effects of coenzyme Q10 nanoparticles (CoQ10-NPs) on hepatotoxicity induced by dichlorvos (DDVP) as an organophosphate. Although CoQ10 is an efficient antioxidant, its poor bioavailability has limited the applications of this useful agent. First, CoQ10-NPs were prepared then characterized using dynamic light scattering (DLS) and transmission electron microscopy (TEM)...
November 16, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29142567/outcomes-of-intravitreal-bevacizumab-and-macular-photocoagulation-for-treatment-of-diabetic-macular-edema-in-a-tertiary-care-eye-hospital-karachi
#10
Adil Salim Jafri, Aziz-Ur-Rehman, Abdul Haleem Mirani, Saleh Memon
Objective: To study the outcomes of intravitreal injection of Bevacizumab and laser photocoagulation in the treatment of diabetic macular edema (DME). Methods: Seventy-two eyes of 59 patients with diabetic macular edema were divided into two groups of 41 eyes (Group-A) and 31 eyes (Group-B). Subjects in group-A were treated with three intravitreal injections of Bevacizumab (IVB), and that of group-B with macular photocoagulation. Duration of study was 9 months. Follow up pattern for both groups was1, 2, 3 and 6 months...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29141246/evaluation-of-temporal-virological-responses-to-interferon-%C3%AE-2b-plus-ribavirin-among-genotype-3a-hepatitis-c-virus-infected-patients
#11
Abida Raza, Muhammad Ovais, Hafsa Aziz, Asim Anwar, Javaid Irfan, Irshad Ahmad, Muhammad Mukhtar
OBJECTIVES: The present study aimed to examine the impact of rapid virological response (RVR) and early virological response (EVR) on sustained virological response (SVR) in chronic hepatitis C genotype 3a individuals. METHODS: The patients were given antiviral therapy with IFN-α-2b, 3 million units 3 times a week and 800-1,200 mg of ribavirin daily adjusted to the patient's body weight (<60 kg 800 mg day-1, and >60 kg 1,200 day-1). The patients received this combination therapy for 24 weeks...
November 16, 2017: Intervirology
https://www.readbyqxmd.com/read/29140693/nonadiabatic-dynamics-of-cycloparaphenylenes-with-td-dftb-surface-hopping
#12
Ljiljana Stojanovic, Saadullah G Aziz, Rifaat Hassan Hilal, Felix Plasser, Thomas A Niehaus, Mario Barbatti
We implemented a version of the decoherence-corrected fewest switches surface hopping based on linear-response time-dependent density functional tight binding (TD-DFTB), enhanced by transition density analysis. The method has been tested for the gas-phase relaxation dynamics of two cycloparaphenylene molecules, [8]CPP and [10]CPP, explaining some important features of their nonadiabatic dynamics, such as the origin of their long fluorescence lifetimes (related to the slow radiative emission from the S1 state) and the trend of increasing the fluorescence rate with the molecular size (related to an increase in the S1-S0 energy gaps and oscillator strengths in the larger molecule)...
November 15, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29140473/jaspar-2018-update-of-the-open-access-database-of-transcription-factor-binding-profiles-and-its-web-framework
#13
Aziz Khan, Oriol Fornes, Arnaud Stigliani, Marius Gheorghe, Jaime A Castro-Mondragon, Robin van der Lee, Adrien Bessy, Jeanne Chèneby, Shubhada R Kulkarni, Ge Tan, Damir Baranasic, David J Arenillas, Albin Sandelin, Klaas Vandepoele, Boris Lenhard, Benoît Ballester, Wyeth W Wasserman, François Parcy, Anthony Mathelier
JASPAR (http://jaspar.genereg.net) is an open-access database of curated, non-redundant transcription factor (TF)-binding profiles stored as position frequency matrices (PFMs) and TF flexible models (TFFMs) for TFs across multiple species in six taxonomic groups. In the 2018 release of JASPAR, the CORE collection has been expanded with 322 new PFMs (60 for vertebrates and 262 for plants) and 33 PFMs were updated (24 for vertebrates, 8 for plants and 1 for insects). These new profiles represent a 30% expansion compared to the 2016 release...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29140291/i-dwrl-improved-dual-wireless-radio-localization-using-magnetometer
#14
Abdul Aziz, Ramesh Kumar, Inwhee Joe
In the dual wireless radio localization (DWRL) technique each sensor node is equipped with two ultra-wide band (UWB) radios; the distance between the two radios is a few tens of centimeters. For localization, the DWRL technique must use at least two pre-localized nodes to fully localize an unlocalized node. Moreover, in the DWRL technique it is also not possible for two sensor nodes to properly communicate location information unless each of the four UWB radios of two communicating sensor nodes cannot approach the remaining three radios...
November 15, 2017: Sensors
https://www.readbyqxmd.com/read/29138009/human-papillomavirus-hpv-infection-in-females-with-normal-cervical-cytology-genotyping-and-phylogenetic-analysis-among-women-in-punjab-pakistan
#15
Hafsa Aziz, Huma Iqbal, Humera Mahmood, Shazia Fatima, Muhammad Faheem, Areej Abdul Sattar, Sobia Tabassum, Sanum Napper, Syeda Batool, Nuzhat Rasheed
OBJECTIVE: Cervical cancer is the fourth most common cancer in the world, seventh overall with account for an estimated 300,000 annual deaths. HPV is the second most common cause of cervical cancer worldwide. HPV screening is not a common practice in Pakistan. The present study aims to determine the prevalence of HPV and HPV types in females with normal cytology of cervix in Upper and Lower region of Punjab Pakistan and analyze the risk factors for HPV in this region. METHOD: In this study, we performed PCR analysis for 1011 female patients with normal cytology of cervix from various districts in Punjab Province, Pakistan and risk factors for acquisition of HPV were studied...
November 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29135985/evidence-based-restructuring-of-health-and-social-care
#16
Aziz Sheikh
In this Perspective, Aziz Sheikh discusses research to evaluate health policy changes in the provision of care, commenting on a study by James Lopez Bernal and colleagues that examined specialist-dominated hospital care versus community-based care in the United Kingdom.
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29135618/pathway-for-the-management-of-hyperglycemia-in-the-cardiac-care-unit
#17
Seyed Hamed Hosseini Dehkordi, Jeanine Albu, Emad F Aziz, Eyal Herzog
Inpatient hyperglycemia has been associated with increased morbidity and mortality in critically ill patients. Optimal control of blood glucose (BG) levels using insulin infusion protocols has been shown to improve clinical outcomes. Protocols have been developed to prescribe a safe and effective rate of insulin infusion for optimal control of BG levels; however, a major obstacle in their implementation is their complexity. We have revised and updated our previously published pathway for the management of hyperglycemia, which introduces the "wheel" concept for insulin dosing...
December 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29135373/high-dose-of-silymarin-in-patients-with-decompensated-liver-disease-a-randomized-controlled-trial
#18
Waleed Fouad Fathalah, Mohamed AbdAllah Abdel Aziz, Neveen Helmy Abou El Soud, Maissa El Said El Raziky
Hepatitis C virus (HCV) is a major public health problem being the most common cause of chronic liver disease in Egypt. HCV-induced decompensated liver cirrhosis patients have a median survival of 2 years even with currently used new treatments. Silymarin is the most commonly used herbal product in chronic liver disease for its anti-inflammatory, antiviral, antioxidant, and antifibrotic effects. The aim of this study was to assess the effects of silymarin in high dose on the clinical and biochemical status of chronic HCV-associated decompensated liver cirrhosis...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29134969/the-prevalence-and-impact-of-overlapping-rome-iv-diagnosed-functional-gastrointestinal-disorders-on-somatization-quality-of-life-and-healthcare-utilization-a-cross-sectional-general-population-study-in-three-countries
#19
Imran Aziz, Olafur S Palsson, Hans Törnblom, Ami D Sperber, William E Whitehead, Magnus Simrén
OBJECTIVES: The population prevalence of Rome IV-diagnosed functional gastrointestinal disorders (FGIDs) and their cumulative effect on health impairment is unknown. METHODS: An internet-based cross-sectional health survey was completed by 5,931 of 6,300 general population adults from three English-speaking countries (2100 each from USA, Canada, and UK). Quota-based sampling was used to generate demographically balanced and population representative samples with regards to age, sex, and education level...
November 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29134599/phage-genome-annotation-using-the-rast-pipeline
#20
Katelyn McNair, Ramy Karam Aziz, Gordon D Pusch, Ross Overbeek, Bas E Dutilh, Robert Edwards
Phages are complex biomolecular machineries that have to survive in a bacterial world. Phage genomes show many adaptations to their lifestyle such as shorter genes, reduced capacity for redundant DNA sequences, and the inclusion of tRNAs in their genomes. In addition, phages are not free-living, they require a host for replication and survival. These unique adaptations provide challenges for the bioinformatics analysis of phage genomes. In particular, ORF calling, genome annotation, noncoding RNA (ncRNA) identification, and the identification of transposons and insertions are all complicated in phage genome analysis...
2018: Methods in Molecular Biology
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