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https://www.readbyqxmd.com/read/28811780/role-of-vitamin-d-in-reducing-number-of-acute-exacerbations-in-chronic-obstructive-pulmonary-disease-copd-patients
#1
Dur Muhammad Khan, Aziz Ullah, Fawad Ahmad Randhawa, Somia Iqtadar, Nasir Farooq Butt, Khadija Waheed
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is characterized by chronic incompletely reversible poor airflow and air trapping and usually this debilitating disorder limits the outside activities of the patients depriving them of sunlight which is a rich source of Vitamin D. The objective of this study was to determine the effect of vitamin D supplementation in reducing number of acute exacerbation in COPD patients. METHODS: This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore from January to December 2015 as exacerbations of COPD are season dependent...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811770/clinical-and-laboratory-profile-of-children-with-cystic-fibrosis-experience-of-a-tertiary-care-center-in-pakistan
#2
Danish Abdul Aziz, Abdul Gaffar Billoo, Ahad Qureshi, Misha Khalid, Salman Kirmani
OBJECTIVE: To determine the clinical presentation, diagnostic investigations and laboratory workup done in admitted children with cystic fibrosis at Aga Khan University Hospital Karachi, Pakistan. METHODS: This is athree years retrospective study from January 2013 to December 2015 conducted at The Aga Khan University Hospital Karachi Pakistan, enrolling admitted patient from birth to 15 years of either gender, diagnosed with CF on the basis of clinical features and positive sweat chloride test...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28810824/laparoscopic-donor-nephrectomy-early-experience-at-a-single-center-in-pakistan
#3
Rehan Mohsin, Asad Shehzad, Uspal Bajracharya, Bux Ali, Tahir Aziz, Muhammed Mubarak, Altaf Hashmi, Adibul Hasan Rizvi
OBJECTIVES: Laparoscopic donor nephrectomy has become the criterion standard for kidney retrieval from living donors. There is no information on the experience and outcomes of laparoscopic donor nephrectomy in Pakistan. The objective of the study was to identify benefits and harms of using laparoscopic compared with open nephrectomy techniques for renal allograft retrieval. MATERIALS AND METHODS: In this a retrospective study, patient files from May 2014 to September 2015 were analyzed...
August 13, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28810243/evaluating-critical-brain-radiation-doses-in-the-treatment-of-multiple-brain-lesions-with-gamma-knife-radiosurgery
#4
Mustafa Aziz Hatiboglu, Kerime Akdur
BACKGROUND: Treatment of patients with multiple brain metastases has shifted to stereotactic radiosurgery, withholding whole-brain (WB) radiation therapy. However, radiation toxicity to the brain is a concern when treating multiple brain lesions with single-fraction stereotactic radiosurgery. OBJECTIVE: The purpose of this study was to determine the changes in brain radiation doses when treating various numbers of targets and lesion volumes. METHODS: We simulated different treatment plans with different combinations of varying tumor volumes including 0...
August 16, 2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28807720/comparison-of-the-therapeutic-effects-of-sildenafil-citrate-heparin-and-neuropeptides-in-a-rat-model-of-acetic-acid-induced-gastric-ulcer
#5
Mehmet Kalayci, Mehmet Ali Kocdor, Tuncay Kuloglu, İbrahim Sahin, Mehmet Sarac, Aziz Aksoy, Meltem Yardim, Semih Dalkilic, Onur Gursu, Suna Aydin, Ramazan Fazil Akkoc, Meltem Cokugras, Gokhan Artas, İbrahim Hanifi Ozercan, Kader Ugur, Suleyman Aydin
AIMS: The purpose of our investigative work has been to determine whether there can be therapeutic roles in the administration of sildenafil citrate, heparin and several neuropeptides on an animal model where gastric ulcers were induced with acetic acid, and to compare their efficacy. MATERIALS AND METHODS: The animals were divided into 13 groups, with 4 animals in each. Gastric ulcers was induced in the animals of 12 groups with one untreated group being left as the control (Group I - control; given normal saline (NS))...
August 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/28803543/bodipy-based-dye-for-no-wash-live-cell-staining-and-imaging
#6
Alexey A Pakhomov, Igor E Deyev, Natalia M Ratnikova, Stepan P Chumakov, Veronika B Mironiuk, Yuriy N Kononevich, Aziz M Muzafarov, Vladimir I Martynov
In nonpolar solvents, hydrophobic organic fluorophores often show bright fluorescence, whereas in polar media, they usually suffer from aggregation-caused quenching (ACQ). Here, we harnessed this solvatochromic behavior of a 1,3,5,7-tetramethyl-BODIPY derivative for cell staining and applied it to live-cell imaging and flow cytometry. As opposed to commercially available dyes, this BODIPY derivative showed excellent contrast immediately after staining and did not require any wash-off.
August 1, 2017: BioTechniques
https://www.readbyqxmd.com/read/28802125/novel-4-3-4-oxo-5-2-oxoindolin-3-ylidene-thiazolidin-2-ylidene-amino-benzenesulfonamides-synthesis-carbonic-anhydrase-inhibitory-activity-anticancer-activity-and-molecular-modelling-studies
#7
Wagdy M Eldehna, Mahmoud F Abo-Ashour, Alessio Nocentini, Paola Gratteri, Ibrahim H Eissa, Mohamed Fares, Omnia E Ismael, Hazem A Ghabbour, Mahmoud M Elaasser, Hatem A Abdel-Aziz, Claudiu T Supuran
Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino)benzenesulfonamides (4a-m and 7a-g). All the newly prepared sulfonamides were in vitro investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IV and IX, using a stopped-flow CO2 hydrase assay. In particular, hCA isoforms II and IX (tumor-associated) were more susceptible to inhibition by the synthesized derivatives, with KIs in the range of 2...
August 1, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28798994/intra-operative-fluoroscopic-radiation-exposure-in-orthopaedic-trauma-theatre
#8
Mustafa S Rashid, Sheweidin Aziz, Syed Haydar, Simon S Fleming, Amit Datta
INTRODUCTION: Radiation exposure from intra-operative fluoroscopy in orthopaedic trauma surgery is a common occupational hazard. References for fluoroscopy use in the operating room for commonly performed operations have not been reported adequately. This study aimed to report appropriate intra-operative fluoroscopy use in orthopaedic trauma and compare the effect of surgery type and surgeon grade on radiation exposure. METHODS: Data on 849 cases over an 18-month period were analysed retrospectively...
August 10, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28798238/molecular-mechanisms-and-genomic-maps-of-dna-excision-repair-in-e-coli-and-humans
#9
Jinchuan Hu, Christopher P Selby, Sheera Adar, Ogun Adebali, Aziz Sancar
Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system the DNA damage is removed by concerted dual incisions bracketing the damage and at precise distance from the damage. Here, we review the basic mechanisms of excision repair in E.coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.
August 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28796402/protection-of-melatonin-in-experimental-models-of-newborn-hypoxic-ischemic-brain-injury-through-mt1-receptor
#10
Bharati Sinha, Qiaofeng Wu, Wei Li, Yanyang Tu, Ana C Sirianni, Yanchun Chen, Jiying Jiang, Xinmu Zhang, Shuanhu Zhou, Wu Chen, Russel J Reiter, Simon Manning, Nirav J Patel, Ali M Aziz-Sultan, Terri E Inder, Robert M Friedlander, Jianfang Fu, Xin Wang
The function of melatonin as a protective agent against newborn hypoxic-ischemic (H-I) brain injury is not yet well studied, and the mechanisms by which melatonin causes neuroprotection in neurological diseases is still evolving. The present study was designed to investigate whether expression of MT1 receptors is reduced in newborn H-I brain injury and whether the protective action of melatonin is by alterations of the MT1 receptors. We demonstrated that there was significant reduction in MT1 receptors in ischemic brain of mouse pups in vivo following H-I brain injury and that melatonin offers neuroprotection through upregulation of MT1 receptors...
August 10, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28794855/allergen-immunotherapy-for-allergic-rhinoconjunctivitis-a-systematic-overview-of-systematic-reviews
#11
REVIEW
Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Graham Roberts, Oliver Pfaar, Antonella Muraro, Ignacio J Ansotegui, Moises Calderon, Cemal Cingi, Stephen Durham, Roy Gerth van Wijk, Susanne Halken, Eckard Hamelmann, Peter Hellings, Lars Jacobsen, Edward Knol, Desiree Larenas-Linnemann, Sandra Y Lin, Vivian Maggina, Hanneke Oude-Elberink, Giovanni Pajno, Ruby Panwankar, Elideanna Pastorello, Constantinos Pitsios, Giuseppina Rotiroti, Frans Timmermans, Olympia Tsilochristou, Eva-Maria Varga, Jamie Wilkinson, Andrew Williams, Margitta Worm, Luo Zhang, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis (ARC). To inform the development of recommendations, we sought to critically assess the systematic review evidence on the effectiveness, safety and cost-effectiveness of AIT for ARC. METHODS: We undertook a systematic overview, which involved searching nine international biomedical databases from inception to October 31, 2015...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28793325/employment-of-single-diode-model-to-elucidate-the-variations-in-photovoltaic-parameters-under-different-electrical-and-thermal-conditions
#12
Fahmi F Muhammad, Mohd Y Yahya, Shilan S Hameed, Fakhra Aziz, Khaulah Sulaiman, Mariwan A Rasheed, Zubair Ahmad
In this research work, numerical simulations are performed to correlate the photovoltaic parameters with various internal and external factors influencing the performance of solar cells. Single-diode modeling approach is utilized for this purpose and theoretical investigations are compared with the reported experimental evidences for organic and inorganic solar cells at various electrical and thermal conditions. Electrical parameters include parasitic resistances (Rs and Rp) and ideality factor (n), while thermal parameters can be defined by the cells temperature (T)...
2017: PloS One
https://www.readbyqxmd.com/read/28790051/severe-aortic-complications-in-a-patient-with-variant-shone-s-complex-and-bicuspid-aortic-valve
#13
Mashrafi Ahmed, Hany Aziz, Leng Jiang
No abstract text is available yet for this article.
August 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28790028/staged-retroperitoneal-mesenteric-revascularisation-and-aortobifemoral-bypass-after-endovascular-rescue-for-acute-mesenteric-ischaemia
#14
Shepard Peir Johnson, Melani Lighter, Harry Linne Anderson, Abdulhameed Aziz
Visceral artery revascularisation through a retroperitoneal approach provides an infrequent yet viable, alternative means of managing mesenteric ischaemia in patients with previous abdominal operations. We present a unique case implementing this surgical approach in a 55-year-old man in which we performed a retroperitoneal aortobifemoral bypass with concomitant retrograde jump graft from the aortic prosthesis to the superior mesenteric artery (SMA) for bilateral lower extremity rest pain and chronic mesenteric ischaemia...
August 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28789908/synthesis-and-carbonic-anhydrase-inhibition-of-polycyclic-imides-incorporating-n-benzenesulfonamide-moieties
#15
Andrea Angeli, Alaa A-M Abdel-Aziz, Alessio Nocentini, Adel S El-Azab, Paola Gratteri, Claudiu T Supuran
A series of polycyclic imides was prepared by reaction of the benzenesulfonamide with an appropriate polycyclic acid anhydride in refluxing glacial acetic acid. The synthesized mono- and bis-sulfonamides were evaluated as a carbonic anhydrase inhibitors (CA, EC 4.2.1.1), more precisely against the human (h) isoforms hCA I, II, IX and XII, some of which are involved in various pathologies, such as glaucoma, epilepsy and cancer. Several low nanomolar and isoform-selective hCA II, IX and XII inhibitors were detected, and the structure-activity relationship for CA inhibition with this class of compounds is discussed in details...
July 29, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28782393/chemical-composition-and-cytotoxic-activity-of-garcinia-atroviridis-griff-ex-t-anders-essential-oils-in-combination-with-tamoxifen
#16
Wen-Nee Tan, Jia-Qin Lim, Fatin Afiqah, Nik Nur Syazni Nik Mohamed Kamal, Fatin Athirah Abdul Aziz, Woei-Yenn Tong, Chean-Ring Leong, Jun-Wei Lim
Garcinia atroviridis Griff. ex T. Anders. is used as a medication agent in folkloric medicine. The present study was to examine the chemical composition of the stem bark and leaf of G. atroviridis as well as their cytotoxic effects against MCF-7 cells. The constituents obtained by hydrodistillation were identified using GC-MS. The stem bark oil (EO-SB) composed mainly the palmitoleic acid (51.9%) and palmitic acid (21.9%), while the leaf oil (EO-L) was dominated by (E)-β-farnesene (58.5%) and β-caryophyllene (16...
August 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28780324/acinetobacter-baumannii-virulence-is-enhanced-by-the-combined-presence-of-virulence-factors-genes-phospholipase-c-plcn-and-elastase-lasb
#17
Sawsan Mohammed Kareem, Israa M S Al-Kadmy, Marwah Hasan Al-Kaabi, Sarah Naji Aziz, Mohammad Ahmad
The ability of multidrug resistance Acinetobacter baumannii to persist in any circumstances regard to the acquisition of many virulence factors genes and antibiotic resistance genes is major concern in the hospitals environments. In this study, thirty A. baumannii isolates were collected from blood infections from hospitalized patients were subjected to screening for virulence factors genes plcN and lasB by conventional PCR. The pathogenicity of representative isolates bearing these gene were tested using galleria mellonella infection assay and adhesion-invasion assay on A549 cell line, and compared with other strain without this gene...
August 2, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28779838/the-membrane-protein-single-shot-amplification-recipe-memstar
#18
Abdul Aziz-Qureshi, Pascal F Meier, Chiara Lee, David Drew
Here, we present a simple overexpression condition for high-throughput screening of membrane proteins in Escherichia coli. For the vast majority of bacterial membrane protein targets tested the MEMbrane protein Single shoT Amplification Recipe-MemStar-leads to high production yields of target protein. The use of MemStar has facilitated structural studies of several transport proteins.
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28777609/physically-realizable-space-for-the-purity-depolarization-plane-for-polarized-light-scattering-media
#19
Aziz Tariq, Pengcheng Li, Dongsheng Chen, Donghong Lv, Hui Ma
We propose a physically realizable space for the polarized light scattering measurement using the Stokes-Mueller formalism by a purity-index-depolarization-index (PI-P_{Δ}) plane. The parameter PI is defined from indices of polarimetric purity (IPP), which exhibits the overall magnitude of the polarimetric randomness of a medium, while the depolarization index (P_{Δ}) delineates a proper global degree of polarimetric purity and may also refer to the average measure of depolarization power of the scattering medium...
July 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28777458/increased-expression-of-pd-l1-and-pd-l2-in-dermal-fibroblasts-from-alopecia-areata-mice
#20
Yunyuan Li, Ruhi T Kilani, Mohammadreza Pakyari, Gigi Leung, Layla Nabai, Aziz Ghahary
Alopecia areata (AA) is a common autoimmune disorder affecting millions of people worldwide, which manifests as a sudden, non-scarring hair loss. The expression of a pro-inflammatory cytokine, interferon-gamma (INF-γ), has been well established to be involved in the development of AA. As IFN-γ and other cytokines are also known to up-regulate programmed cell death ligand 1 and 2 (PD-L1 and PD-L2), which both negatively control immune responses, we asked whether or not a high number of infiltrated T cells, seen in AA lesions, can modulate the expression of PD-L1 and PD-L2 in skin cells...
August 4, 2017: Journal of Cellular Physiology
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