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juvenile spondyloarthritis

Maria Majdan
Immune-Mediated Inflammatory Diseases (IMIDs) are a group of unrelated conditions that share common inflammatory pathways with immune dysregulation and imbalance in inflammatory cytokines. The aetiology of these conditions is unknown. IMIDs encompassing disorders as diverse as asthma, type 1 and 2 diabetes mellitus, inflammatory bowel diseases (IBD) Crohn disease and ulcerative colitis, rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriasis (Ps), psoriatic arthritis (PsA), uveitis, juvenile idiopathic arthritis (JIA)...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Pamela F Weiss, Nancy A Chauvin, Johannes Roth
PURPOSE OF REVIEW: This review aims to provide an update on the use of imaging in the assessment of juvenile spondyloarthritis (JSpA) disease manifestations. RECENT FINDINGS: Recent studies have demonstrated superior reliability and specificity of MRI for assessment of sacroiliac joint inflammation compared with radiography. The use of gadolinium contrast may not add incremental value to the assessment of inflammatory sacroiliitis. Sacroiliitis is common at diagnosis of spondyloarthritis...
December 2016: Current Rheumatology Reports
Ulf Lindström, Sofia Exarchou, Elisabeth Lie, Mats Dehlin, Helena Forsblad-d'Elia, Johan Askling, Lennart Jacobsson
BACKGROUND: The role of environmental exposures in the pathogenesis of ankylosing spondylitis (AS) remains unclear. In particular, two types of exposures have been suspected to play a role: mechanical stress and infections. The objective of this case-control study was to determine if childhood infections are associated with later development of AS. METHODS: The cases with AS were identified through the Swedish national outpatient specialised-care register, based on having been given at least one AS diagnosis in the register between 2001 and 2010...
October 22, 2016: Arthritis Research & Therapy
Filipa Oliveira-Ramos, Mónica Eusébio, Fernando M Martins, Ana Filipa Mourão, Carolina Furtado, Raquel Campanilho-Marques, Inês Cordeiro, Joana Ferreira, Marcos Cerqueira, Ricardo Figueira, Iva Brito, Helena Canhão, Maria José Santos, José A Melo-Gomes, João Eurico Fonseca
OBJECTIVES: To determine how adult juvenile idiopathic arthritis (JIA) patients fulfil classification criteria for adult rheumatic diseases, evaluate their outcomes and determine clinical predictors of inactive disease, functional status and damage. METHODS: Patients with JIA registered on the Rheumatic Diseases Portuguese Register ( older than 18 years and with more than 5 years of disease duration were included. Data regarding sociodemographic features, fulfilment of adult classification criteria, Health Assessment Questionnaire, Juvenile Arthritis Damage Index-articular (JADI-A) and Juvenile Arthritis Damage Index-extra-articular (JADI-E) damage index and disease activity were analysed...
2016: RMD Open
Miha Lavric, María Auxiliadora Miranda-García, Dirk Holzinger, Dirk Foell, Helmut Wittkowski
Alarmins are endogenous molecules with homeostatic roles that have reached the focus of research in inflammatory arthritis in the last two decades, mostly due to their ability to indicate tissue related damage after active or passive release from injured cells. From HMGB1, S100A8/A9 and S100A12 proteins, over heat-shock proteins (HSPs) and purine metabolites (e.g. uric acid, ATP) to altered matrix proteins and interleukin-33 (IL-33), a number of alarmins have been determined until now as having a role in rheumatoid arthritis, psoriatic and juvenile idiopathic arthritis, as well as spondyloarthritis and gout...
September 19, 2016: Joint, Bone, Spine: Revue du Rhumatisme
E L Nasonov, T V Popkova, D S Novikova
The representatives of immunoinflammatory diseases are rheumatic ones, such as primarily rheumatoid arthritis, juvenile idiopathic arthritis, spondyloarthritis, psoriatic arthritis, systemic lupus erythematosus, and other systemic connective diseases, which are characterized by a high risk for untimely death. The high risk of untimely death in these diseases has been found to be associated with the severity of an immunoinflammatory process that gives rise to severe irreversible damage to vital organs and systems and with the development of a wide spectrum of comorbidities (infections, interstitial lung disease, malignant tumors, osteoporotic fractures, etc...
2016: Terapevticheskiĭ Arkhiv
Matthew L Stoll, Randy Q Cron
PURPOSE OF REVIEW: There has been increasing interest in the contents and function of the microbiota, as it relates to pediatric inflammatory diseases. Here, we discuss the factors underlying the development of the microbiota, its role in juvenile idiopathic arthritis (JIA) and prospects for therapeutic interventions in the microbiota. RECENT FINDINGS: The human microbiota undergoes a succession of changes, until it reaches a mature form. A variety of early-life exposures, including mode of delivery and form of feeding, can affect the contents of the microbiota and possibly impact upon long-term risk of developing autoimmune diseases...
September 2016: Current Opinion in Rheumatology
Cristina Hernández-Díaz, Lucio Ventura-Ríos, Marwin Gutiérrez, Johannes Roth
For the past two decades, musculoskeletal ultrasonography (MSKUS) has developed exponentially and has become an essential tool in rheumatology practice. This development has been far more limited in pediatric rheumatology which is partially related to deficits in the evidence base. Many studies have shown that MSKUS is more sensitive than the clinical examination for detecting synovitis and enthesitis in adults. At the same time, there is a lack of studies demonstrating its validity, reliability, and reproducibility in pediatric rheumatology...
April 2016: Clinical Rheumatology
María Martha Katsicas, Ricardo Russo
The juvenile spondyloarthropathies (JSpA) are a group of related rheumatic diseases characterized by involvement of peripheral large joints, axial joints, and entheses (enthesitis) that begin in the early years of life (prior to 16(th) birthday).The nomenclature and concept of spondyloarthropathies has changed during the last few decades. Although there is not any specific classification of JSpA, diseases under the spondyloarthropathy nomenclature umbrella in the younger patients include: the seronegative enthesitis and arthropathy (SEA) syndrome, juvenile ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated arthritis...
March 12, 2016: Pediatric Rheumatology Online Journal
Wanqing Xie, Lijiang Zhou, Shan Li, Tianqian Hui, Di Chen
Spondyloarthritis (SpA) is a group of diseases consisting of psoriatic arthritis (PsA), reactive arthritis, arthritis related to inflammatory bowel disease (a subgroup of juvenile idiopathic arthritis), and ankylosing spondylitis (the prototype of SpA). Axial bone formation and the combination of concurrent erosion and new bone formation are specific characteristics of SpA disease. The use of antiproinflammatory cytokines, such as inhibitors of tumor necrosis factor α (TNF-α), appears to be the greatest advance in the treatment of SpA over the past 20 years...
January 2016: Annals of the New York Academy of Sciences
Iwona Sudoł-Szopińska, Anne Grethe Jurik, Iris Eshed, Jans Lennart, Andrew Grainger, Mikkel Østergaard, Andrea Klauser, Anne Cotten, Marius C Wick, Mario Maas, Falk Miese, Niels Egund, Nathalie Boutry, Mitja Rupreht, Monique Reijnierse, Edwin H G Oei, Reinhard Meier, Phil O'Connor, Antoine Feydy, Vasco Mascarenhas, Athena Plagou, Paolo Simoni, Hannes Platzgummer, Winston J Rennie, Adam Mester, James Teh, Philip Robinson, Giuseppe Guglielmi, Gunnar Åström, Claudia Schueller-Weiderkamm
This article presents the recommendations of the European Society of Musculoskeletal Radiology Arthritis Subcommittee regarding the standards of the use of MRI in the diagnosis of musculoskeletal rheumatic diseases. The recommendations discuss (1) the role of MRI in current classification criteria of musculoskeletal rheumatic diseases (including early diagnosis of inflammation, disease follow-up, and identification of disease complications); (2) the impact of MRI on the diagnosis of axial and peripheral spondyloarthritis, rheumatoid arthritis, and juvenile spondyloarthritis; (3) MRI protocols for the axial and peripheral joints; (4) MRI interpretation and reporting for axial and peripheral joints; and finally, (5) methods for assessing MR images including quantitative, semiquantitative, and dynamic contrast-enhanced MRI studies...
September 2015: Seminars in Musculoskeletal Radiology
Anita T Shaw, Ellen M Gravallese
Remodeling of bone is a continuous process that occurs throughout life. Under normal physiologic conditions, bone-resorbing osteoclasts and bone-forming osteoblasts are tightly coupled and regulated to ensure proper balance, such that there is no net change in bone mass. However, inflammation perturbs normal bone homeostasis. The impact of inflammation on bone is dependent upon the anatomic site affected, cell types, factors and cytokines present in the local microenvironment, and local mechanical forces. Cytokines are central to the pathogenesis of inflammation-induced bone loss and contribute to the uncoupling of osteoclast-mediated bone resorption and osteoblast-mediated bone formation, thereby disrupting normal remodeling...
January 2016: Seminars in Cell & Developmental Biology
N Herregods, J Dehoorne, R Joos, J L Jaremko, X Baraliakos, A Leus, F Van den Bosch, K Verstraete, L Jans
AIM: To determine the diagnostic utility of magnetic resonance imaging (MRI) features of sacroiliitis in juvenile spondyloarthritis (JSpA). MATERIALS AND METHODS: This was a prospective study of 80 paediatric patients who underwent MRI of the sacroiliac joints that were clinically suspected to have sacroiliitis. The prevalence of MRI features of active and structural lesions of sacroiliitis was recorded. Patients were classified according to the International League of Association for Rheumatology criteria...
December 2015: Clinical Radiology
Marija Perica, Mandica Vidović, Lovro Lamot, Lana Tambić Bukovac, Sanja Kapitanović, Magdalena Perić, Jerko Barbić, Miroslav Harjaček
No abstract text is available yet for this article.
December 2015: Clinical Rheumatology
Alain Saraux, Jacques Benichou, Loic Guillevin, Latifa Idbrik, Chantal Job-Deslandre, Jean Sibilia, Marc Soudant, Daniel Wendling, Francis Guillemin
OBJECTIVES: Limited information is available about the characteristics of patients with active inflammatory rheumatic diseases who start TNF-α antagonist therapy. Our objective was to assess TNF-α antagonist prescription patterns in this context in France. METHODS: Between 2007 and 2009, 102 rheumatologists, internists, and pediatricians in French university hospitals and private practice prospectively recruited biologics-naïve patients with active rheumatoid arthritis (RA) (DAS28>3...
September 2015: Clinical and Experimental Rheumatology
Pamela F Weiss, Rui Xiao, David M Biko, Nancy A Chauvin
OBJECTIVE: To evaluate the prevalence of sacroiliitis at diagnosis of juvenile spondyloarthritis (SpA) and the accuracy of physical examination and back pain to detect sacroiliitis, using imaging as the reference standard. METHODS: We performed a prospective cross-sectional study of 40 children with newly diagnosed juvenile SpA and 14 healthy controls. Subjects were assessed using physical examination, anteroposterior pelvic radiograph, and pelvic magnetic resonance imaging (MRI)...
February 2016: Arthritis Care & Research
N Herregods, J L Jaremko, X Baraliakos, J Dehoorne, A Leus, K Verstraete, L Jans
OBJECTIVE: The aim of this study is to determine the added diagnostic value of contrast-enhanced (CE) magnetic resonance imaging (MRI) compared to routine non contrast-enhanced MRI to detect active sacroiliitis in clinically juvenile spondyloarthritis (JSpA). MATERIALS AND METHODS: A total of 80 children clinically suspected for sacroiliitis prospectively underwent MRI of the sacroiliac (SI) joints. Axial and coronal T1-weighted (T1), Short-tau inversion recovery (STIR) and fat-saturated T1-weighted gadolinium-DTPA (Gd) contrast-enhanced (T1/Gd) sequences were obtained...
November 2015: Skeletal Radiology
Lucie Hromadkova, Tomas Soukup, Jiri Vlcek
RATIONALE, AIMS AND OBJECTIVES: In rheumatic disorders, one of the treatment objectives is to improve the patient's quality of life (QoL). Similar to other chronic conditions, drug compliance is poor, but necessary for successful treatment. The relationship between drug compliance and QoL has never been tested. The aim of this study was to elucidate the relationship between drug compliance and QoL in patients with different rheumatic disorders. METHOD: A cross-sectional study was conducted and patients ≥18 years of age with rheumatoid arthritis (RA), spondyloarthritis (SA), juvenile idiopathic arthritis (JIA) and systemic scleroderma (SSc) were recruited...
October 2015: Journal of Evaluation in Clinical Practice
Sabrina Gmuca, Pamela F Weiss
PURPOSE OF REVIEW: This article provides a comprehensive update of the pathogenesis, diagnostic imaging, treatments, and disease activity measurements of juvenile spondyloarthritis (JSpA). RECENT FINDINGS: Genetic and microbiome studies have provided new information regarding possible pathogenesis of JSpA. Recent work suggests that children with JSpA have decreased thresholds for pain in comparison to healthy children. In addition, pain on physical examination and abnormalities on ultrasound of the entheses are not well correlated...
July 2015: Current Opinion in Rheumatology
Tejpal Gill, Mark Asquith, James T Rosenbaum, Robert A Colbert
PURPOSE OF REVIEW: Microbial dysbiosis in the gut is emerging as a common component in various inflammatory disorders including spondyloarthritis (SpA). The depth of this influence has begun to be realized with next-generation sequencing of the gut microbiome providing unbiased assessment of previously uncharted bacterial populations. RECENT FINDINGS: Decreased numbers of Firmicutes, a major phyla of gut commensals, especially the species Faecalibacterium prausnitzii and Clostridium leptum have been found in various inflammatory disorders including SpA and inflammatory bowel disease (IBD), and could be an important link between SpA and gut inflammation...
July 2015: Current Opinion in Rheumatology
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