keyword
MENU ▼
Read by QxMD icon Read
search

FCM

keyword
https://www.readbyqxmd.com/read/28643901/ferric-carboxymaltose-in-patients-with-restless-legs-syndrome-and-nonanemic-iron-deficiency-a-randomized-trial
#1
Claudia Trenkwalder, Juliane Winkelmann, Wolfgang Oertel, Garth Virgin, Bernard Roubert, Anna Mezzacasa
BACKGROUND: Compromised iron status is important in restless legs syndrome pathophysiology. We compared the efficacy and tolerability of ferric carboxymaltose (single intravenous dose) versus placebo for restless legs syndrome treatment in iron-deficient nonanemic patients. METHODS: Patients with moderate to severe restless legs syndrome and serum ferritin < 75 μg/L (or serum ferritin 75-300 μg/L and transferrin saturation < 20%) were randomized to ferric carboxymaltose (1000 mg iron) or placebo...
June 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28641652/-significance-of-monitoring-minimal-residual-disease-by-flow-cytometry-in-acute-leukemia-patients-underwent-nonmyeloablative-allo-hsct
#2
Xiong-Xiong Liu, Tie-Qiang Liu, Mei Guo, Qi-Yun Sun, Jian-Hui Qiao, Kai-Xun Hu, Bing-Xia Li, Bo Yao, Chang-Lin Yu
OBJECTIVE: To explore the value of dynamically monitoring minimal residual disease (MRD) by flow cytometry before and after non-myeloablative allo-HSCT (NST) for prediction of acute leukemia(AL) relapse after transplantation. METHODS: The clinical data of 51 AL patients underwent NST were analyzed retrospectively in Department of Hematology of Affiliated Hospital of Academy of Military Medical Sciences from January 2011 to December 2015. All AL patients achieved the morphologic complete remission of bone marrow before transplantation...
June 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28628003/clinical-effectiveness-and-cost-effectiveness-results-from-the-randomised-phase-iib-trial-in-previously-untreated-patients-with-chronic-lymphocytic-leukaemia-to-compare-fludarabine-cyclophosphamide-and-rituximab-with-fludarabine-cyclophosphamide-mitoxantrone
#3
Dena R Howard, Talha Munir, Lucy McParland, Andy C Rawstron, Anna Chalmers, Walter M Gregory, John L O'Dwyer, Alison Smith, Roberta Longo, Abraham Varghese, Alexandra Smith, Peter Hillmen
BACKGROUND: The conventional frontline therapy for fit patients with chronic lymphocytic leukaemia (CLL) is fludarabine, cyclophosphamide and rituximab (FCR). Rituximab (Mabthera(®), Roche Products Ltd) targets the CD20 antigen, which is expressed at low levels in CLL. The standard dose of rituximab in CLL (375 mg/m(2) in cycle 1 and 500 mg/m(2) in cycles 2-6) was selected based on toxicity data only. Small doses of rituximab (as low as 20 mg) have biological activity in CLL, with an immediate reduction in circulating CLL cells and down-regulation of CD20...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28625992/flow-cytometry-a-powerful-novel-tool-to-assess-viability-of-fungal-conidia-in-metal-working-fluids
#4
D Vanhauteghem, K Demeyere, N Callaert, A Boelaert, G Haesaert, K Audenaert, E Meyer
Fungal contamination of metal working fluids (MWF) is a dual problem in automatized processing plants because resulting fungal biofilms obstruct cutting, drilling and polishing machines. Moreover, some fungal species of MWF comprise pathogens such as Fusarium solani Therefore, the development of an accurate analytical tool to evaluate conidia viability in MWF is important. We developed a flow cytometric method to measure fungal viability in MWF using F. solani as model organism. To validate this method, viable and dead conidia were mixed in several proportions and flow cytometrically analyzed...
June 16, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28617574/synergistic-suppression-of-tumor-angiogenesis-by-co-delivering-of-vegf-targeted-sirna-and-candesartan-mediated-by-functionalized-carbon-nanovectors
#5
Xuefang Ding, Yujie Su, Cheng Wang, Fangrong Zhang, Kerong Chen, Yu Wang, Min Li, Wei Wang
Single-walled carbon nanotubes (SWNTs) with unique physicochemical properties have exhibited promising biomedical applications as drug/gene carrier. In this study, polyethyleneimine (PEI) modified SWNT conjugates linked with candesartan (CD) were developed to deliver vascular endothelial growth factor (VEGF) targeted siRNA (siVEGF) for synergistic and targeted treatment of tumor angiogenesis. The characterization results revealed that SWNT-PEI-CD conjugates were successfully synthesized, and exhibited desirable dispersibility and superior stability...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28614775/changes-in-viability-of-rat-adipose-derived-stem-cells-isolated-from-abdominal-perinuclear-adipose-tissue-stimulated-with-pulsed-electromagnetic-field
#6
A Baranowska, B Skowron, B Nowak, K Ciesielczyk, P Guzdek, K Gil, J Kaszuba-Zwoinska
Previous experiments demonstrated that low-frequency electromagnetic field (LF-EMF) may activate cellular death pathways in proliferating cells. Therefore, we hypothesized that LF-EMF may also influence viability of highly proliferating undifferentiated adipose-derived stem cells. Obesity is classified as a civilization disease; its etiopathogenesis is presumed to include both genetic predisposition and influence of modified environmental factors, such as unbalanced diet with excess calories and/or too low physical activity...
April 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28612555/-bone-morphogenetic-proteins-from-ct26-regulate-the-expression-of-pd-l1-in-murine-dendritic-cells-and-macrophages
#7
Mao-Yuan Zhao, Yu-Yi Wang, Chi Du, Feng Luo
OBJECTIVES: To analyze the influence of bone morphogenetic proteins (BMPs) from CT26 on PD-L1 of dendritic cells and macrophages. METHODS: In vivo, we respectively inoculated CT26 colon cancer cells subcutaneously and intraperitoneally to BALB/c mice.The mice were randomly assigned to three groups and treated with normal saline; BMPs inhibitor LDN193189; BMPs inhibitor LDN193189 combined with paclitaxel, respectively. The treatments started on the eighth day after inoculating, when the tumor volume reached 150 mm(3) or the abdominal circumference was greater than 6 cm...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28611603/inactivation-of-the-lateral-entorhinal-area-increases-the-influence-of-visual-cues-on-hippocampal-place-cell-activity
#8
Kristin M Scaplen, Rohan N Ramesh, Negin Nadvar, Omar J Ahmed, Rebecca D Burwell
The hippocampus is important for both navigation and associative learning. We previously showed that the hippocampus processes two-dimensional (2D) landmarks and objects differently. Our findings suggested that landmarks are more likely to be used for orientation and navigation, whereas objects are more likely to be used for associative learning. The process by which cues are recognized as relevant for navigation or associative learning, however, is an open question. Presumably both spatial and nonspatial information are necessary for classifying cues as landmarks or objects...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28600831/absolute-bacterial-cell-enumeration-using-flow-cytometry
#9
F Ou, C McGoverin, S Swift, F Vanholsbeeck
AIM: To evaluate a flow cytometry protocol that uses reference beads for the enumeration of live and dead bacteria present in a mixture. METHODS AND RESULTS: Mixtures of live and dead Escherichia coli with live:dead concentration ratios varying from 0 to 100% were prepared. These samples were stained using SYTO 9 and propidium iodide and 6 μm beads reference beads were added. Bacteria present in live samples were enumerated by agar plate counting. Bacteria present in dead samples were enumerated by agar plate counting before treatment with isopropanol...
June 10, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28599653/dynamics-of-transcriptional-re-programming-of-syncytial-nuclei-in-developing-muscles
#10
Laetitia Bataillé, Hadi Boukhatmi, Jean-Louis Frendo, Alain Vincent
BACKGROUND: A stereotyped array of body wall muscles enables precision and stereotypy of animal movements. In Drosophila, each syncytial muscle forms via fusion of one founder cell (FC) with multiple fusion competent myoblasts (FCMs). The specific morphology of each muscle, i.e. distinctive shape, orientation, size and skeletal attachment sites, reflects the specific combination of identity transcription factors (iTFs) expressed by its FC. Here, we addressed three questions: Are FCM nuclei naive? What is the selectivity and temporal sequence of transcriptional reprogramming of FCMs recruited into growing syncytium? Is transcription of generic myogenic and identity realisation genes coordinated during muscle differentiation? RESULTS: The tracking of nuclei in developing muscles shows that FCM nuclei are competent to be transcriptionally reprogrammed to a given muscle identity, post fusion...
June 9, 2017: BMC Biology
https://www.readbyqxmd.com/read/28599216/fuzzy-risk-stratification-and-risk-assessment-model-for-clinical-monitoring-in-the-icu
#11
Albion Dervishi
BACKGROUND: The decisions that clinicians make in intensive care units (ICUs) based on monitored parameters reflecting physiological deterioration are of major medical and biomedical engineering interest. These parameters have been investigated and assessed for their usefulness in risk assessment. METHODS: Totally, 127 ICU adult patients were studied. They were selected from a MIMIC II Waveform Database Matched Subset and had continuous monitoring of heart rate, invasive blood pressure, and oxygen saturation...
June 2, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28598081/-mir-183-regulates-proliferation-of-sw1990-pancreatic-cancer-cell-line-by-targeting-pdcd4
#12
Ying-Ying Lu, Yue Zeng, Jun-Yuan Zheng, Chun-Lan Huang, Xing-Peng Wang
OBJECTIVES: To investigate the effect of miR-183 on the cell proliferation in SW1990 pancreatic cancer cell line by targeting programmed cell death factor 4(PDCD4). METHODS: The SW1990 pancreatic cancer cells were transfected with miR-183 mimics and inhibitors at different concentrations, the alteration of PDCD4 levels was observed at specific concentrations by qPCR and Western blot. The cellular proliferation of transfected cells was determined by MTT assay. The distribution of cell cycle and apoptosis was examined by flow cytometry (FCM) and Hoechst 33258 staining...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28596913/polyanhydride-micelles-with-diverse-morphologies-for-shape-regulated-cellular-internalization-and-blood-circulation
#13
Guang Yang, Jie Wang, Dan Li, Shaobing Zhou
Biodegradable amphiphilic poly (ethylene glycol) (PEG) based ether-anhydride terpolymer, consisting of PEG, 1, 3-bis (p-carboxyphenoxy) propane (CPP) and sebacic acid (SA), namely PEG-CPP-SA terpolymer, was employed to self-assemble into micelles by adding water into a solution of the terpolymer in tetrahydrofuran (THF). The shape of polyanhydride micelles can be regulated by simply adjusting the water addition rate, where spherical, rod-like and comb-like micelles can obtained under water addition rate of 20, 3 and 1 ml/h, respectively...
June 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/28591365/expression-dynamics-of-caveolin-1-in-fibroblasts-of-newborn-rats-with-chronic-lung-disease-and-its-impact-on-lung-fibroblast-proliferation
#14
Xin Wang, Jian-Hua Fu, Xin-Dong Xue
Purpose: To evaluate the changes of caveolin-1 in lung fibroblasts in newborn Wistar rats when exposed to hyperoxic conditions, as well as lung fibroblasts cell cycle. Methods: One hundred newborn Wistar rats were randomly divided (50 rats/group) into experimental and control groups, exposed to hyperoxic conditions or normal air, respectively. The fraction of inspired oxygen (FiO2) in the experimental group was 90%, whereas this value was 21% in the control group...
May 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28590745/sensitive-detection-of-staphylococcus-aureus-with-vancomycin-conjugated-magnetic-beads-as-enrichment-carriers-combined-with-flow-cytometry
#15
Xiangyu Meng, Guotai Yang, Fulai Li, Taobo Liang, Weihua Lai, Hengyi Xu
A novel sandwich strategy was designed to detect Staphylococcus aureus. The strategy is based on an antibacterial agent that captures bacterial cells and a fluorescein-labeled antibody that acts as the signal-output probe. Vancomycin (Van), which exerts a strong antibacterial effect on Gram-positive bacteria, was utilized as a molecular recognition agent to detect pathogenic bacteria. To effectively concentrate S. aureus, we used bovine serum albumin (BSA) as the amplification carrier to modify magnetic beads (MBs), which were then functionalized with Van...
June 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28587632/meta-analysis-of-cell-specific-transcriptomic-data-using-fuzzy-c-means-clustering-discovers-versatile-viral-responsive-genes
#16
Atif Khan, Dejan Katanic, Juilee Thakar
BACKGROUND: Despite advances in the gene-set enrichment analysis methods; inadequate definitions of gene-sets cause a major limitation in the discovery of novel biological processes from the transcriptomic datasets. Typically, gene-sets are obtained from publicly available pathway databases, which contain generalized definitions frequently derived by manual curation. Recently unsupervised clustering algorithms have been proposed to identify gene-sets from transcriptomics datasets deposited in public domain...
June 6, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28587299/remote-sensing-image-change-detection-based-on-nsct-hmt-model-and-its-application
#17
Pengyun Chen, Yichen Zhang, Zhenhong Jia, Jie Yang, Nikola Kasabov
Traditional image change detection based on a non-subsampled contourlet transform always ignores the neighborhood information's relationship to the non-subsampled contourlet coefficients, and the detection results are susceptible to noise interference. To address these disadvantages, we propose a denoising method based on the non-subsampled contourlet transform domain that uses the Hidden Markov Tree model (NSCT-HMT) for change detection of remote sensing images. First, the ENVI software is used to calibrate the original remote sensing images...
June 6, 2017: Sensors
https://www.readbyqxmd.com/read/28583787/coatings-in-food-contact-materials-potential-source-of-genotoxic-contaminants
#18
Birgit Mertens, M Van Bossuyt, S Fraselle, M N Blaude, T Vanhaecke, V Rogiers, L Verschaeve, E Van Hoeck
Up till now, no harmonized EU regulation exists on chemicals used in coatings for food contact materials (FCM). Therefore, these substances need to comply with the general provisions of EU Regulation 1935/2004 and, if present, with national legislation. Different 'inventory lists' of compounds that might be present in coatings are available, but for hundreds of these substances, the potential human health impact of their use in FCM coatings has not (recently) been evaluated. Since detailed evaluation of all compounds is not feasible, a pragmatic approach was developed to identify substances with a potential concern for human health...
June 3, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28583013/probabilistic-migration-modelling-focused-on-functional-barrier-efficiency-and-low-migration-concepts-in-support-of-risk-assessment
#19
Rainer Brandsch
Migration modelling provides reliable migration estimates from food contact materials (FCM) to food or food simulants based on mass transfer parameters like diffusion- and partition coefficients related to individual materials. In most cases mass transfer parameters are not readily available from the literature and for this reason are estimated with a given uncertainty. Historically uncertainty was accounted for by introducing upper limit concepts first, turning out to be of limited applicability due to highly overestimated migration results...
June 6, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28582930/optimal-three-dimensional-reconstruction-for-lung-cancer-tissues
#20
Xiaoguang Huang, Shihong Yue, Chuanlei Wang, Huaxiang Wang
The existing three-dimensional (3D) x-ray reconstruction methods for lung cancer tissue reconstruct the investigated objects based on a series of two-dimensional (2D) image sections and a chosen 3D reconstruction algorithm. However, because these procedures apply the same segmentation method for all 2D image sections, they may not achieve the optimal segmentation for each section. As a result, the reconstructed 3D images have limited spatial resolution. Furthermore, the existing 3D reconstruction method is time-consuming and results in a limited time resolution...
May 26, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
keyword
keyword
106220
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"