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https://www.readbyqxmd.com/read/27907058/choice-of-high-dose-intravenous-iron-preparation-determines-hypophosphatemia-risk
#1
Benedikt Schaefer, Philipp Würtinger, Armin Finkenstedt, Vickie Braithwaite, André Viveiros, Maria Effenberger, Irene Sulzbacher, Alexander Moschen, Andrea Griesmacher, Herbert Tilg, Wolfgang Vogel, Heinz Zoller
BACKGROUND: Ferric carboxymaltose (FCM) and iron isomaltoside 1000 (IIM) are increasingly used because they allow correction of severe iron deficiency in a single infusion. A transient decrease in serum phosphate concentrations is a frequent side effect of FCM. AIM: To characterize this adverse event and search for its predictors in a gastroenterology clinic patient cohort. METHODS: Electronic medical records of patients attending the University Hospital of Innsbruck were searched for the keywords ferric carboxymaltose or iron isomaltoside...
2016: PloS One
https://www.readbyqxmd.com/read/27898407/expression-pattern-and-regulatory-role-of-microrna-23a-in-conjugated-linoleic-acids-induced-apoptosis-of-adipocytes
#2
Renli Qi, Qi Wang, Jing Wang, Jinxiu Huang, Shan Jiang, Rong Xiao, Zuohua Liu, Feiyun Yang
BACKGROUND/AIMS: Conjugated linoleic acids (CLAs) are known to induce apoptosis in adipocytes; however, the cellular mechanisms involved remained illdefined. We explored the different apoptotic induction effects of two CLA isomers on adipocytes and then investigated the expression and function of microRNAs (miRNAs) related to the apoptosis. METHODS: TUNEL and FCM assays were used to detect CLAs-induced adipocyte apoptosis. Microarrays were used to compare the differential expression of miRNAs...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27898179/temporal-kinetics-of-cd8-cd28-and-cd8-cd28-t-lymphocytes-in-the-injured-rat-spinal-cord
#3
Yan Wu, Yu-Hong Lin, Ling-Ling Shi, Zong-Feng Yao, Xiu-Mei Xie, Zheng-Song Jiang, Jie Tang, Jian-Guo Hu, He-Zuo Lü
This study aims to explore the temporal changes of cytotoxic CD8(+) CD28(+) and regulatory CD8(+) CD28(-) T-cell subsets in the lesion microenvironment after spinal cord injury (SCI) in rats, by combination of immunohistochemistry (IHC) and flow cytometry (FCM). In the sham-opened spinal cord, few CD8(+) T cells were found. After SCI, the CD8(+) T cells were detected at one day post-injury (dpi), then markedly increased and were significantly higher at 3, 7, and 14 dpi compared with one dpi (p < 0.01), the highest being seven dpi...
November 29, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27892828/qualitative-and-quantitative-analysis-of-monomers-in-polyesters-for-food-contact-materials
#4
Fabrian Brenz, Linke Susanne, Simat Thomas
Polyesters (PES) are gaining more importance on the food contact material (FCM) market and the variety of properties and applications is expected to be wide. In order to acquire the desired properties manufacturers can combine several FCM approved polyvalent carboxylic acids (PCA) and polyols as monomers. However, information about the qualitative and quantitative composition of FCM articles is often limited. The method presented here describes analysis of PES with the identification and quantification of 25 polyester monomers (10 PCA, 15 polyols) by HPLC with diode array detection (HPLC-DAD) and GC-MS after alkaline hydrolysis...
November 28, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27890369/anti-tumor-activity-of-tanshinone-iia-in-combined-with-cyclophosphamide-against-lewis-mice-with-lung-cancer
#5
Qi Li, Ke Hu, Si Tang, Li-Fang Xu, Yu-Chuan Luo
OBJECTIVE: To explore the anti-tumor activity of tanshinone IIA in combined with cyclophosphamide against Lewis mice with lung cancer and the effect on cellular immune function. METHODS: Lewis tumor cells were inoculated subcutaneously into the right armpit of mice in each group (n = 20) to establish Lewis lung cancer mice model. After model establishment, mice in the model group were given normal saline by lavage, qd. Mice in treatment I group were given intraperitoneal injection of Tan IIA, 15 mg/kg, qd...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27889152/application-of-flow-cytometry-to-wine-microorganisms
#6
REVIEW
Cédric Longin, Clément Petitgonnet, Michèle Guilloux-Benatier, Sandrine Rousseaux, Hervé Alexandre
Flow cytometry (FCM) is a powerful technique allowing detection and enumeration of microbial populations in food and during food process. Thanks to the fluorescent dyes used and specific probes, FCM provides information about cell physiological state and allows enumeration of a microorganism in a mixed culture. Thus, this technique is increasingly used to quantify pathogen, spoilage microorganisms and microorganisms of interest. Since one decade, FCM applications to the wine field increase greatly to determine population and physiological state of microorganisms performing alcoholic and malolactic fermentations...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27878298/trail-overexpression-co-regulated-by-egr1-and-hre-enhances-radiosensitivity-of-hypoxic-a549-cells-depending-on-its-apoptosis-inducing-role
#7
Yan-Ming Yang, Fang Fang, Xin Li, Lei Yu, Zhi-Cheng Wang
Ionizing radiation can upregulate the expression levels of TRAIL and enhance tumor cell apoptosis. While Early growth response 1 (Egr1) gene promoter has radiation inducible characteristics, the expression for exogenous gene controlled by Egr1 promoter could be enhanced by ionizing radiation, but its efficiency is limited by tissue hypoxia. Hypoxia response elements (HREs) are important hypoxic response regulatory sequences and sensitivity enhancers. Therefore, we chose TRAIL as the gene radiotherapy to observe whether it is regulated by Egr1 and HER and its effects on A549 cells and its mechanism...
November 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27867532/left-ventricular-ejection-fraction-recovery-in-patients-with-heart-failure-treated-with-intravenous-iron-a-pilot-study
#8
Julio Núñez, José Vicente Monmeneu, Anna Mollar, Eduardo Núñez, Vicent Bodí, Gema Miñana, Sergio García-Blas, Enrique Santas, Jaume Agüero, Francisco J Chorro, Juan Sanchis, Maria Pilar López-Lereu
AIMS: In patients with heart failure with reduced ejection fraction (HFrEF) and iron deficiency, treatment with intravenous iron has shown a clinical improvement regardless of anaemic status. Cardiac magnetic resonance (CMR) T2* sequence has shown a potential utility for evaluating myocardial iron deficiency. We aimed to evaluate whether T2* sequence significantly changes after ferric carboximaltose (FCM) administration, and if such changes correlate with changes in left ventricle ejection fraction (LVEF)...
December 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27859495/drug-specific-hypophosphatemia-and-hypersensitivity-reactions-following-different-intravenous-iron-infusions
#9
Palle Bager, Christian L Hvas, Jens F Dahlerup
AIMS: Intravenous (IV) iron infusions have been associated with hypophosphatemia (HP) and hypersensitivity reactions (HSRs). No studies have compared the side effects of ferric carboxymaltose (FCM) with those of isomaltoside 1000 (ISM). This study aimed to describe the occurrence of HP and HSRs following the administration of either FCM or ISM. METHODS: Data on 231outpatients treated with IV iron infusions, between November 2011 and April 2014, were collected. During that period, the department made a switch from FCM to ISM and then back to FCM...
November 17, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27858060/-effect-of-different-doses-of-radiation-on-human-salivary-gland-adenoid-cystic-carcinoma-cells
#10
Yu-Meng Huang, Ying Wang, Yong Li, Ping Liu, Xian-Feng Liu, Hong-Wei Zhao
PURPOSE: To explore the effect of different doses of radiation on human salivary gland adenoid cystic carcinoma cells (SACC-83, SACC-LM). METHODS: Different doses of radiation (0, 2, 4, 6, 8, 10 Gy) were applied to SACC-83, SACC-LM cells and the cells were continued to culture for 48 h. CCK-8 test, flow cytometry(FCM) and cell scratch experiment were used to observe cell proliferation, apoptosis and cell migration. SPSS19.0 software package was used for data analysis...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27852236/effects-of-intravenous-iron-on-fibroblast-growth-factor-23-fgf23-in-haemodialysis-patients-a-randomized-controlled-trial
#11
Matthew A Roberts, Louis Huang, Darren Lee, Robert MacGinley, Stefanie M A Troster, Annette B Kent, Sukhvinder S Bansal, Iain C Macdougall, Lawrence P McMahon
BACKGROUND: Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function. We hypothesized that intravenous iron modulates iFGF23 and cFGF23 in haemodialysis patients differently according to the type of iron used. METHODS: Prevalent, stable haemodialysis patients requiring protocol-based intravenous iron therapy were randomized to a single 200 mg dose of either ferric carboxymaltose (FCM) or iron sucrose (IS)...
November 16, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27847341/separation-of-haemocyte-subpopulations-in-shrimp-fenneropenaeus-chinensis-by-immunomagnetic-bead-using-monoclonal-antibody-against-granulocytes
#12
Jing Xing, Yanhong Chang, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
In our previous work, two monoclonal antibodies (Mabs) against granulocytes of shrimp (Fenneropenaeus chinensis) had been produced, in this paper, haemocyte subpopulations were analyzed by flow cytometry (FCM) using the Mabs. Then immunomagnetic bead (IMB) method was applied for separation hyalinocytes and granulocytes using the Mabs. The separated hyalinocytes and granulocytes were analyzed by FCM, indirect immunofluorescence assay, Giemsa staining and transmission electron microscopy, respectively. The results showed the proportion of hyalinocytes in haemolymph of F...
November 12, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27823710/clinical-efficacy-of-ferric-carboxymaltose-treatment-in-patients-with-restless-legs-syndrome
#13
Yong Won Cho, Richard P Allen, Christopher J Earley
OBJECTIVE: There have been three randomized, placebo-controlled, double-blind studies of intravenous iron in restless legs syndrome (RLS), with differing outcomes. The one positive study used ferric carboxymaltose (FCM) at a total dose of 1000 mg. The purpose of this study was to replicate and extend the findings from the prior FCM study. METHODS: Non-anemic, idiopathic RLS patients were enrolled in a randomized, double-blinded, placebo-controlled study and received either 1000 mg FCM or placebo as a single infusion (phase I)...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27816922/rediscovering-peritoneal-macrophages-in-a-murine-endometriosis-model
#14
Ming Yuan, Dong Li, Min An, Qiuju Li, Lu Zhang, Guoyun Wang
STUDY QUESTION: What are the features of peritoneal macrophage subgroups and T helper cells in the development of murine endometriosis? SUMMARY ANSWER: During the development of endometriosis in a murine model, large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs) are polarized into M1 and M2 cells, respectively, and the proportions of T helper (Th) 1, Th17 and T regulatory (Treg) cells are increased. WHAT IS KNOWN ALREADY: Numerous studies investigating the etiology and pathogenesis of endometriosis have focused on the polarization states of peritoneal macrophages in endometriosis models and patients, but the results are inconclusive...
November 5, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27816673/comparison-of-balb-c-and-cba-j-mice-for-the-local-lymph-node-assay-using-bromodeoxyuridine-with-flow-cytometry-llna-brdu-fcm
#15
Yong Sun Lee, Jung-Sun Yi, Souk Jin Seo, Joo Hwan Kim, Mi-Sook Jung, Im-Kwon Seo, Ilyoung Ahn, Kyungyuk Ko, Tae Sung Kim, Kyung Min Lim, Soojung Sohn
The local lymph node assay using 5-bromo-2-deoxyuridine (BrdU) with flow cytometry (LLNA: BrdU-FCM) is a modified LLNA that is used to identify skin sensitizers by counting BrdU-incorporated lymph node cells (LNCs) with flow cytometry. Unlike other LLNA methods (OECD TG 429, 442A and 442B) in which the CBA/J mouse strain is used, LLNA: BrdU-FCM was originally designed to be compatible with BALB/c, a mouse strain that is more widely used in many countries. To justify the substitution of CBA/J for BALB/c, the equivalence of the test results between two strains shall be established prior to the official implementation of LLNA: BrdU-FCM...
November 2, 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27815456/applicability-of-commercially-available-elisa-kits-for-the-quantification-of-faecal-immunoreactive-corticosterone-metabolites-in-mice
#16
Klas S P Abelson, Otto Kalliokoski, Anne Charlotte Teilmann, Jann Hau
BACKGROUND: Commercially available ELISA kits are popular among investigators that quantify faecal corticosterone or cortisol metabolites (FCM) for stress assessment in animals. However, in faeces, these assays mainly detect immunoreactive glucocorticoid metabolites. Since different assays contain antibodies of different origin, the detection level and cross-reactivity towards different metabolites and other steroids differ considerably between assays. Thus, the validity of one assay for FCM quantification in stress assessment is not necessarily the same for another assay...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27815157/excretion-and-measurement-of-corticosterone-and-testosterone-metabolites-in-bank-voles-myodes-glareolus
#17
Saana Sipari, Hannu Ylönen, Rupert Palme
The bank vole is a commonly used model species in behavioral and ecophysiological studies. Thus, presenting a validated method for noninvasive monitoring of corticosterone and testosterone secretion is of high relevance. Here, we evaluated the effect of time of day and an ACTH challenge test on measured fecal corticosterone (FCM) and testosterone (FTM) metabolites in both sexes. Furthermore, we performed radiometabolism experiments for both steroids and sexes to study metabolism and excretion of (3)H-corticosterone and (3)H-testosterone...
November 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27810378/a-pipeline-for-developing-and-testing-staining-protocols-for-flow-cytometry-demonstrated-with-sybr-green-i-and-propidium-iodide-viability-staining
#18
Alina Nescerecka, Frederik Hammes, Talis Juhna
The increasing use of flow cytometry (FCM) for analyses of environmental samples has resulted in a large variety of staining protocols with varying results and limited comparability. Viability assessment with FCM is in this context of particular interest because incorrect staining could severely affect the outcome/interpretation of the results. Here we propose a pipeline for the development and optimization of staining protocols for environmental samples, demonstrated with the common viability dye combination of SYBR Green I (SG) and propidium iodide (PI)...
October 31, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/27796559/mitochondrial-pathways-are-involved-in-eimeria-tenella-induced-apoptosis-of-chick-embryo-cecal-epithelial-cells
#19
Shan Li, Ming-Xue Zheng, Huan-Cheng Xu, Xiao-Zhen Cui, Yan Zhang, Li Zhang, Sha-Sha Yang, Zhi-Yong Xu, Rui Bai, Xu-Guang Sun
Accumulating evidence suggests that Eimeria tenella severely damages the intestinal mucosa in infected poultry, resulting in deadly haemorrhagic typhlocolitis and major economic losses. Damage to host tissue is believed to arise mainly from apoptosis, which is, in general, intimately related to mitochondrial function. However, it is unclear whether mitochondria-dependent apoptotic pathways are specifically involved in parasite-induced apoptosis of chick embryo cecal epithelial cells. Because the mitochondrial permeability transition pore (MPTP) and caspase-9 are important elements in these pathways, we studied the effects of their respective inhibitors (i...
October 28, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27792739/long-term-bacterial-dynamics-in-a-full-scale-drinking-water-distribution-system
#20
E I Prest, D G Weissbrodt, F Hammes, M C M van Loosdrecht, J S Vrouwenvelder
Large seasonal variations in microbial drinking water quality can occur in distribution networks, but are often not taken into account when evaluating results from short-term water sampling campaigns. Temporal dynamics in bacterial community characteristics were investigated during a two-year drinking water monitoring campaign in a full-scale distribution system operating without detectable disinfectant residual. A total of 368 water samples were collected on a biweekly basis at the water treatment plant (WTP) effluent and at one fixed location in the drinking water distribution network (NET)...
2016: PloS One
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