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https://www.readbyqxmd.com/read/29924777/-vascular-stents-approaches-used-to-increase-their-clinical-efficacy
#1
K A Kuznetsov, M V Khar'kova, A A Karpenko, P P Laktionov
Using stents for endovascular restoration of blood flow made a revolution in vascular surgery, however, despite numerous variants of stents presented on the pharmacological market, there are no stents which would completely solve the problem of restenosis in the area of stent placement. In order to decrease growth of the neointima of the stented portions of vessels, stents coated with cytostatic and cytotoxic agents were worked out. To optimize the rate of drug release it was suggested to apply them in a mixture with biodegradable or biostable polymers...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924706/microneurography-how-it-started-and-how-it-works
#2
Åke Bernhard Vallbo
This historical review describes in the first section endeavors to develop a method to record the normal traffic of impulses in human nerves, designated microneurography. The method was developed in the Department of Clinical Neurophysiology of the Academic Hospital in Uppsala, Sweden, starting in 1965. Microneurography involves the impalement of a peripheral nerve with a tungsten needle electrode. Electrode position is adjusted by hand until activity of interest is discriminated. A similar technique had not previously been tried in animal preparations; hence the large number of successful studies based on recording afferent activity in other mammals did not offer pertinent methodological guidance...
June 20, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29924678/bleeding-at-removal-of-nuss-bar-rare-but-sometimes-significant
#3
Nina S Cohen, Michael J Goretsky, Robert J Obermeyer
BACKGROUND: Hemorrhage during Nuss bar removal is an uncommon but feared complication that can be life threatening if not controlled rapidly. This study aims to identify the incidence and sources of large volume hemorrhage, discuss successful management strategies, and provide patient care recommendations. METHODS: An IRB approved (#15-11-WC-0214), single institution retrospective chart review was performed on patients who underwent Nuss bar removal over a 15-year interval...
June 20, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29924462/timing-and-mechanism-of-conceptus-demise-in-a-complement-regulatory-membrane-protein-deficient-mouse
#4
Michael P Triebwasser, Xiaobo Wu, Paula Bertram, Dennis E Hourcade, Donald Michael Nelson, John P Atkinson
PROBLEM: Crry is a widely expressed type 1 transmembrane complement regulatory protein in rodents which protects self-tissue by downregulating C3 activation. Crry-/- concepti produced by Crry+/-  × Crry+/- matings are attacked by maternal complement system leading to loss before day 10. The membrane attack complex is not the mediator of this death. We hypothesized that the ability of C3b to engage the alternative pathway's feedback loop relatively unchecked on placental membranes induces the lesion yielding the demise of the Crry-/- mouse...
June 20, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29924214/effect-of-red-propolis-on-hamster-cheek-pouch-angiogenesis-in-a-new-sponge-implant-model
#5
Nayanna de Oliveira Ramos Melo, Camila de Carvalho Juanes, Mayara Freire de Alencar Alves, Emiliano Tiago Melo Silva, Francisco Vagnaldo Fechine Jamacaru, Telma Leda Gomes de Lemos, Conceição Aparecida Dornelas
PURPOSE: To evaluate the effects of red propolis on cheek pouch angiogenesis in a hamster new model sponge implant. METHODS: Forty eight animals divided into eight groups. (Groups I-IV), the animals were treated for 15 days before and 10 days after sponge implantation. (Groups V-VIII), the animals were treated for 10 days after sponge implantation (GI and GV: red propolis 100 mg/kg, GII and GVI: celecoxib 20 mg/kg, GIII and GVII: 1% gum arabic 5 mL/kg, GIV and GVIII: distilled water 5 mL/kg)...
May 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29923763/novel-haemodynamic-structures-in-the-human-glomerulus
#6
Christopher R Neal, Kenton Arkill, James Stephen Bell, Kai B Betteridge, David O Bates, C Peter Winlove, Andrew Hj Salmon, Steven J Harper
To investigate human glomerular structure under conditions of physiological perfusion we have analysed fresh and perfusion fixed normal human glomeruli at physiological hydrostatic and oncotic pressures using serial resin section reconstruction, confocal, multiphoton and electron microscope imaging. Afferent and efferent arterioles (21.5{plus minus}1.2µm and 15.9{plus minus}1.2µm diameter), recognised from vascular origins, lead into previously undescribed wider regions (43.2{plus minus}2.8 µm and 38.4{plus minus}4...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29922978/novel-hydrogel-based-ocular-drug-delivery-system-for-the-treatment-of-conjunctivitis
#7
S Deepthi, Jobin Jose
PURPOSE: Conventional dosage form like eye drops showed poor therapeutic response and also require frequent dosing. Therefore, developing the dosage form to deliver the drug to the target site without much loss of drug or without causing any systemic side effects is the challenging job for the researchers in pharmaceutical industries. OBJECTIVE: The main aim of the present work was to formulate and evaluate hydrogel-based drug delivery containing combination of neomycin sulphate and betamethasone sodium phosphate in order to provide prolonged release and also better bioavailability of drugs for the treatment of eye infections...
June 19, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29922588/toxic-effects-of-lambda-cyhalothrin-on-the-rat-thyroid-involvement-of-oxidative-stress-and-ameliorative-effect-of-ginger-extract
#8
Wael M Al-Amoudi
Lambda-cyhalothrin (LCT) is a synthetic pyrethroid that is widely used to control insecticide. Ginger is a traditional plant that is widely used as a spice or folk medicine. This study evaluates the antioxidant effect of ginger extract on thyroid toxicity induced by LCT in albino rats. Adult Rats were divided into 4 experimental groups: Group 1: control, Group 2: oral ginger treatment (24 mg/ml, 3 days/week for 4 weeks), Group 3: oral LCT treatment (1/100 LD50 , 3 days/week for 4 weeks), Group 4: oral LCT and ginger mixture treatment...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29922566/managing-complications-of-submental-artery-involvement-after-hyaluronic-acid-filler-injection-in-chin-region
#9
Martha Fang, Eqram Rahman, Krishan Mohan Kapoor
Hyaluronic acid dermal fillers are becoming popular all over the world, but due to the presence of many blood vessels in the face, there is always a small possibility of vascular complications. We present a case with the ischemic involvement of chin and neck skin after accidental submental artery involvement after hyaluronic acid filler injection for chin region. Impending skin necrosis on the chin and upper neck on the right side was diagnosed quickly by observing the skin changes in the immediate postfiller phase...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29922396/effect-of-intracranial-stenosis-revascularization-on-dynamic-and-static-cerebral-autoregulation
#10
Santiago Ortega-Gutierrez, Edgar A Samaniego, Amy Huang, Arjun Masurkar, Binbin Zheng-Lin, Colin P Derdeyn, David Hasan, Randolph Marshall, Nils Petersen
Introduction: Severe intracranial stenosis might lead to acute cerebral ischemia. It is imperative to better assess patients who may benefit from immediate reperfusion and blood pressure management to prevent injury to peri-infarct tissue. Methods: We assessed cerebral autoregulation using static and dynamic methods in an 81-year-old woman suffering acute cerebral ischemia from severe intracranial stenosis in the petrous segment of the left internal carotid artery (LICA)...
June 2018: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29922175/vascular-morphogenesis-in-the-context-of-inflammation-self-organization-in-a-fibrin-based-3d-culture-system
#11
Beate M Rüger, Tanja Buchacher, Alexander Giurea, Bernd Kubista, Michael B Fischer, Johannes M Breuss
Introduction: New vessel formation requires a continuous and tightly regulated interplay between endothelial cells with cells of the perivascular microenvironment supported by mechanic-physical and chemical cues from the extracellular matrix. Aim: Here we investigated the potential of small fragments of synovial tissue to form de novo vascular structures in the context of inflammation within three dimensional (3D) fibrin-based matrices in vitro , and assessed the contribution of mesenchymal stromal cell (MSC)-immune cell cross-talk to neovascularization considering paracrine signals in a fibrin-based co-culture model...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29922015/particle-embolization-of-systemic-to-pulmonary-collateral-artery-networks-in-congenital-heart-disease-technique-and-special-considerations
#12
Sarosh P Batlivala, William E Briscoe, Makram R Ebeid
Systemic-to-pulmonary artery collateral networks commonly develop in patients with single-ventricle physiology and chronic hypoxemia. Although these networks augment pulmonary blood flow, much of the flow is ineffective and contributes to cardiac volume loading. This volume loading can have detrimental effects, especially for single-ventricle patients. Some data suggest that occluding collaterals may improve outcomes after subsequent operations, especially when the volume of collateral flow is significant. Traditional practice has been to coil occlude the feeding vessel...
May 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29921751/thoracic-outlet-syndrome-biomechanical-and-exercise-considerations
#13
REVIEW
Nicholas A Levine, Brandon R Rigby
Thoracic outlet syndrome (TOS) describes a group of disorders that are due to a dynamic compression of blood vessels or nerves, between the clavicle and first rib or cervical vertebral nerve roots. Individuals with TOS typically experience upper limb pain, numbness, tingling, or weakness that is exacerbated by shoulder or neck movement. The causes of TOS vary, and can include abrupt movements, hypertrophy of the neck musculature, and anatomical variations in which the brachial plexus roots pass through this musculature, edema, pregnancy, repeated overhead motions, the blockage of an artery or vein, or abnormal posture...
June 19, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29921303/a-rare-case-of-perivascular-epithelioid-cell-tumor-pecoma-of-the-greater-omentum
#14
Koichi Okamoto, Yuka Okada, Kohei Ohno, Takahiro Yagi, Mitsuo Tsukamoto, Takuya Akahane, Ryu Shimada, Tamuro Hayama, Takeshi Tsuchiya, Keijiro Nozawa, Keiji Matsuda, Tsuyoshi Ishida, Fukuo Kondo, Yojiro Hashiguchi
BACKGROUND: A tumor composed exclusively or predominantly of human melanin black 45 (HMB45)-positive epithelioid cells is called a perivascular epithelioid cell tumor (PEComa). We report a very rare case of a PEComa of the greater omentum. CASE PRESENTATION: MRI conducted to examine the orthopedic disease of the patients, a 49-year-old Japanese woman, also identified a tumor in her pelvis. A CT scan revealed a tumor mass on the right side of the pelvic floor and clear nutrient vessels originating from the splenic and celiac arteries...
June 19, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29921235/tgf-%C3%AE-signaling-promotes-tumor-vasculature-by-enhancing-the-pericyte-endothelium-association
#15
Justin Zonneville, Alfiya Safina, Alexander M Truskinovsky, Carlos L Arteaga, Andrei V Bakin
BACKGROUND: The breast cancer microenvironment promotes tumor vascularization through the complex interactions involving tumor-associated fibroblasts (TAFs). Emerging data indicate that TAFs increase production and signaling by TGF-β cytokines, while the role of TGF-β signaling in the regulation of tumor blood vessels is not fully understood. The current study presents evidence that TAFs enhance the organization of tumor blood capillaries, and TGF-β signaling plays an important role in this response...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29921198/potential-applications-of-venom-peptides-as-anti-thrombotic-agents-in-arterial-deep-vein-thrombosis
#16
Samiullah Khan, Aqsa Gul, Rabia Noreen, Muhammad Ashraf, Sohail Ahmad, Sattar Bakhsh Awan
BACKGROUND: Thrombus is composed of two main substances i.e. red blood cells and aggregated platelets which make a web of inter-connected fibrin proteins. During injury it prevents bleeding, so it is very useful but it can be very dangerous if it is produced in healthy blood vessels and block the blood flow through it. Mural thrombi attaches with the blood vessels but in most cases do not block it completely. Venoms are an incredible source of peptides having amazing bioactivities with varying number of amino acid residues...
June 13, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29920959/label-free-volumetric-imaging-of-conjunctival-collecting-lymphatics-ex-vivo-by-optical-coherence-tomography-lymphangiography
#17
Peijun Gong, Dao-Yi Yu, Qiang Wang, Paula Yu, Karol Karnowski, Morgan Heisler, Ashley Francke, Dong An, Marinko V Sarunic, David D Sampson
We employ optical coherence tomography (OCT) and optical coherence microscopy (OCM) to study conjunctival lymphatics in porcine eyes ex vivo. This study is a precursor to the development of in vivo imaging of the collecting lymphatics for potentially guiding and monitoring glaucoma filtration surgery. OCT scans at 1300 nm and higher-resolution OCM scans at 785 nm reveal the lymphatic vessels via their optical transparency. Equivalent signal characteristics are also observed from blood vessels largely free of blood (and devoid of flow) in the ex vivo conjunctiva...
June 19, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29920914/robot-assisted-percutaneous-screw-placement-combined-with-pelvic-internal-fixator-for-minimally-invasive-treatment-of-unstable-pelvic-ring-fractures
#18
Hua-Shui Liu, Sheng-Jun Duan, Shi-Dong Liu, Feng-Shuang Jia, Li-Ming Zhu, Min-Cen Liu
PURPOSE: The purpose of this study was to investigate the safety and efficacy of the combination of robot-assisted percutaneous screw placement and pelvic internal fixator (INFIX) for minimally invasive treatment of unstable anterior and posterior pelvic ring injuries. METHODS: From September 2016 to June 2017, twenty-four patients with unstable anterior and posterior pelvic ring injuries were treated with TiRobot-assisted percutaneous sacroiliac cannulated screw fixation on the posterior pelvic ring combined with robot-assisted pedicle screw placement in the anterior inferior iliac spine along with INFIX on the anterior pelvic ring...
June 19, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/29920373/gridloc-an-automatic-and-unsupervised-localization-method-for-high-density-ecog-grids
#19
Mariana P Branco, Michael Leibbrand, Mariska J Vansteensel, Zachary V Freudenburg, Nick F Ramsey
Precise localization of electrodes is essential in the field of high-density (HD) electrocorticography (ECoG) brain signal analysis in order to accurately interpret the recorded activity in relation to functional anatomy. Current localization methods for subchronically implanted HD electrode grids involve post-operative imaging. However, for situations where post-operative imaging is not available, such as during acute measurements in awake surgery, electrode localization is complicated. Intra-operative photographs may be informative, but not for electrode grids positioned partially or fully under the skull...
June 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29917239/sodium-nitroprusside-dilates-cerebral-vessels-and-enhances-internal-carotid-artery-flow-in-young-men
#20
Niels D Olesen, Mads Fischer, Niels H Secher
KEY POINTS: Sodium nitroprusside lowers blood pressure by vasodilation but is reported to reduce cerebral blood flow. In healthy young men sodium nitroprusside reduced blood pressure, total peripheral resistance, and arterial CO2 tension and yet cerebral blood flow was maintained with an increase in internal carotid artery blood flow and cerebrovascular conductance. Sodium nitroprusside induces both systemic and cerebral vasodilation affecting internal carotid artery more than vertebral artery flow...
June 19, 2018: Journal of Physiology
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