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https://www.readbyqxmd.com/read/28230584/microsurgical-replantation-of-total-avulsed-scalp-extending-the-limits
#1
Yunbo Jin, Chen Hua, Xiaojie Hu, Hui Chen, Gang Ma, Yun Zou, Bin Chen, Dongze Lyu, Mathias Tremp, Xiaoxi Lin
BACKGROUND: Avulsion of the scalp is a rare but severe trauma and challenging to the reconstructive surgeon. It poses not only physical concussion but also significant persisting psychological distress to the patients. METHODS: Medical records from 5 patients who suffered scalp avulsion were reviewed retrospectively. The following data and methods were assessed: age, number of vessels repaired, method of replantation, vein grafts required, blood transfusion, ischemia time, total operating time, and percentage of scalp survival...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28230009/effect-of-heat-sink-on-the-recurrence-of-small-malignant-hepatic-tumors-after-radiofrequency-ablation
#2
Zheng-Yu Lin, Guo-Lin Li, Jin Chen, Zhong-Wu Chen, Yi-Ping Chen, Sun-Zhi Lin
AIMS: The aim of this study was to investigate the effect of heat sink on the recurrence of hepatic malignant tumors <3 cm after percutaneous radiofrequency ablation (RFA). SUBJECTS AND METHODS: This study included 564 hepatic malignant tumors <3 cm in 381 patients. Preoperative images were used to determine whether these tumors were adjacent to vessels, and the diameter of adjacent vessels was measured. RFA was performed computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound (US) guidance, and postoperative imaging follow-up was then conducted...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28229426/assessment-of-mirna-regulation-of-endothelial-progenitor-cell-mediated-angiogenesis
#3
Darukeshwara Joladarashi, Prasanna Krishnamurthy
Organ outgrowth, embryonic development, wound healing, and many such processes require the process of angiogenesis, whereby new blood vessels are developed from the preexisting vessels. microRNAs (miRs) are 18-24 nucleotide-containing endogenous RNAs that, via a posttranscriptional mechanism, exert substantial gene regulatory effects. It was discovered by recent advances that, through direct targeting of certain critical secretory factors and transcription factors, miRs exert potent angiogenic control in a cell autonomous and non-cell autonomous manner...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28228970/comparison-of-endothelial-function-improvement-estimated-with-reactive-hyperemia-index-between-ramipril-and-telmisartan-in-hypertensive-patients
#4
You-Jeong Ki, Jae-Bin Seo, Hack-Lyoung Kim, Woo-Hyun Lim, Hye Yeon Seo, Jin Yong Lee, Woo-Young Chung
BACKGROUND: Endothelium has a function to regulate vascular tone by releasing mediators either vasodilating or vasoconstricting blood vessels. Endothelial dysfunction can be measured conveniently by Reactive Hyperemia Index (RHI) with a peripheral arterial tonometry. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II (AT II) receptor blockers (ARBs) are considered to have beneficial effects on endothelium through inhibition of AT II. This study was performed to compare the effect of ACEIs or ARBs on endothelial function estimated by RHI in hypertensive patients...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28228933/vascularization-and-innervation-of-slits-within-polydimethylsiloxane-sheets-in-the-subcutaneous-space-of-athymic-nude-mice
#5
Rachel E Gurlin, Mark T Keating, Shiri Li, Jonathan Rt Lakey, Sébastien de Feraudy, Bhupinder S Shergill, Elliot L Botvinick
Success of cell therapy in avascular sites will depend on providing sufficient blood supply to transplanted tissues. A popular strategy of providing blood supply is to embed cells within a functionalized hydrogel implanted within the host to stimulate neovascularization. However, hydrogel systems are not always amenable for removal post-transplantation; thus, it may be advantageous to implant a device that contains cells while also providing access to the circulation so retrieval is possible. Here we investigate one instance of providing access to a vessel network, a thin sheet with through-cut slits, and determine if it can be vascularized from autologous materials...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28228880/crossed-nonfused-renal-ectopia-with-variant-blood-vessels-a-rare-congenital-renal-anomaly
#6
Nawal Ebrahim Al-Hamar, Khalid Khan
Crossed renal ectopia is a rare congenital anomaly, where one of the kidneys crosses the midline and lies opposite to the site of its normal ureteral insertion. Ninety percent of crossed ectopic kidneys are fused to their ipsilateral uncrossed kidney. Crossed renal ectopia without fusion is rare. We present the case of a 53-year-old male with an unusual incidental finding of crossed nonfused renal ectopia, with the left ectopic kidney lying anterior to the right kidney without fusion. The ectopic kidney had dual arterial supply: one from the aorta and another from the right renal artery...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28228736/stress-signal-network-between-hypoxia-and-er-stress-in-chronic-kidney-disease
#7
REVIEW
Hiroshi Maekawa, Reiko Inagi
Chronic kidney disease (CKD) is characterized by an irreversible decrease in kidney function and induction of various metabolic dysfunctions. Accumulated findings reveal that chronic hypoxic stress and endoplasmic reticulum (ER) stress are involved in a range of pathogenic conditions, including the progression of CKD. Because of the presence of an arteriovenous oxygen shunt, the kidney is thought to be susceptible to hypoxia. Chronic kidney hypoxia is induced by a number of pathogenic conditions, including renal ischemia, reduced peritubular capillary, and tubulointerstitial fibrosis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28228623/elucidation-of-mechanism-of-blood-brain-barrier-damage-for-prevention-and-treatment-of-vascular-dementia
#8
Masaki Ueno
It is well-known that the blood-brain barrier (BBB) plays significant roles in transporting intravascular substances into the brain. The BBB in cerebral capillaries essentially impedes the influx of intravascular compounds from the blood to the brain, while nutritive substances, such as glucose, can be selectively transported through several types of influx transporters in endothelial cells. In the choroid plexus, intravascular substances can invade the parenchyma as fenestrations exist in endothelial cells of capillaries...
February 22, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28228483/new-concepts-and-mechanisms-of-platelet-activation-signaling
#9
REVIEW
Brian Estevez, Xiaoping Du
Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall and soluble agonists, which initiate platelet activation, leading to formation of hemostatic thrombi. Pathological activation of platelets can induce occlusive thrombosis, resulting in ischemic events such as heart attack and stroke, which are leading causes of death globally. Platelet activation requires intracellular signal transduction initiated by platelet receptors for adhesion proteins and soluble agonists. Whereas many platelet activation signaling pathways have been established for many years, significant recent progress reveals much more complex and sophisticated signaling and amplification networks...
March 2017: Physiology
https://www.readbyqxmd.com/read/28228406/renal-inflammation-and-injury-is-associated-with-lymphangiogenesis-in-hypertension
#10
Sterling C Kneedler, Lauren E Phillips, Kayla R Hudson, Katharine M Beckman, Catalina A Lopez Gelston, Joseph M Rutkowski, Alan R Parrish, Peter A Doris, Brett M Mitchell
Lymphatic vessels are vital for the trafficking of immune cells from the interstitium to draining lymph nodes during inflammation. Hypertension is associated with renal infiltration of activated immune cells and inflammation, however it is unknown how renal lymphatic vessels change in hypertension. We hypothesized that renal macrophage infiltration and inflammation would cause increased lymphatic vessel density in hypertensive rats. Spontaneously hypertensive rats (SHR) that exhibit hypertension and renal injury (SHR-A3 strain) had significantly increased renal lymphatic vessel density and macrophages at 40 weeks of age compared to Wistar-Kyoto (WKY) controls...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28228404/endothelial-colony-forming-cells-ameliorate-endothelial-dysfunction-via-secreted-factors-following-ischemia-reperfusion-injury
#11
Jason A Collett, Purvi Mehrotra, Allison Crone, W Christopher Shelley, Mervin C Yoder, David P Basile
Damage to endothelial cells contributes to acute kidney injury (AKI) by leading to impaired perfusion. Endothelial colony-forming cells (ECFCs) are endothelial precursor cells with high proliferative capacity, pro-angiogenic activity, and in vivo vessel forming potential. We hypothesized that ECFCs may ameliorate the degree of AKI and/or promote repair of the renal vasculature following ischemia/reperfusion (I/R). Rat pulmonary microvascular ECs (PMVEC) with high proliferative potential were compared with pulmonary artery ECs (PAEC) with low proliferative potential in rats subjected to renal I/R...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28228299/maternal-hyperhomocysteinemia-and-congenital-heart-defects-a-prospective-case-control-study-in-indian-population
#12
Reyaz A Malik, Mohd R Lone, Asif Ahmed, Kaisar A Koul, Rahid R Malla
OBJECTIVE: Very few studies have been conducted in this part of world to identify relation between maternal serum homocysteine levels and congenital heart disease in their offsprings. With this perspective in mind, this study was carried out. METHODS: Fifty women were enrolled in this study. Thirty of these had delivered neonates who were diagnosed to have congenital heart diseases. These were treated as cases. Twenty of these women had delivered neonates who did not have any congenital heart diseases and were treated as controls...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228068/stress-in-gastrointestinal-tract-and-stable-gastric-pentadecapeptide-bpc-157-finally-do-we-have-a-solution
#13
Predrag Sikiric, Sven Seiwerth, Rudolf Rucman, Domagoj Drmic, Mirjana Stupnisek, Antonio Kokot, Marko Sever, Ivan Zoricic, Zoran Zoricic, Lovorka Batelja, Tihomil Ziger, Josipa Vlainic, Zarko Rasic, Martina Lovric Bencic
Selye's syndrome produced by diverse nocuous agents and "response to damage as such" means Selye's stress triad in stress coping response to reestablish homeostasis. Logically, from the gastrointestinal tract viewpoint, such organoprotective/healing response implies the angiogenic growth factors that commonly signify the healing. Thereby, the gastric pentadecapeptide BPC 157-organoprotection (huge range of beneficial effects) signifies the Selye's stress concept/stress coping response implemented in and from gastrointestinal tract, and BPC 157 as an integrative mediator that integrates the adaptive bodily response to stress...
February 20, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28227984/preliminary-study-on-the-automated-skull-fracture-detection-in-ct-images-using-black-hat-transform
#14
Ayumi Yamada, Atsushi Teramoto, Tomoko Otsuka, Kohei Kudo, Hirofumi Anno, Hiroshi Fujita, Ayumi Yamada, Atsushi Teramoto, Tomoko Otsuka, Kohei Kudo, Hirofumi Anno, Hiroshi Fujita, Tomoko Otsuka, Hiroshi Fujita, Ayumi Yamada, Kohei Kudo, Hirofumi Anno, Atsushi Teramoto
Linear skull fracture, following head trauma, may reach major blood vessels, such as the middle meningeal artery or sinus venosus, and may cause epidural hematoma. However, hematoma is likely to be missed in the initial interpretation because it spreads only gradually. In addition, the fracture lines that run along the scan slice plane are often missed during initial interpretation. In this study, we develop a novel method for automated detection of the linear skull fracture using head computed tomography (CT) images and conduct a basic evaluation using digital phantom and head phantom that enclose genuine human bones...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227904/a-potential-function-based-scalpel-navigation-method-that-avoids-blood-vessel-groups-during-excision-of-cancerous-tissue
#15
Hiroshi Noborio, Kazuma Aoki, Takahiro Kunii, Kiminori Mizushino, Hiroshi Noborio, Kazuma Aoki, Takahiro Kunii, Kiminori Mizushino, Hiroshi Noborio, Kazuma Aoki, Kiminori Mizushino, Takahiro Kunii
This study developed support software for liver surgeons; the software can apply potential functions to blood vessels and cancerous tissue and can adjust repulsion and attraction accordingly. Thus, the scalpel can be directly provided with the power to operate on cancerous cells only from a fixed distance, and accidental cutting of blood vessels can be avoided. The direct support provided by this force navigation allows physicians to safely and reliably navigate past blood vessel groups in order to precisely perform excision surgery for liver cancer...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227867/knife-edge-scanning-microscopy-for-in-silico-study-of-cerebral-blood-flow-from-biological-imaging-data-to-flow-simulations
#16
Michael R Nowak, Alexander Lozovskiy, Dimitri Dobroskok, Yoonsuck Choe, Michael R Nowak, Alexander Lozovskiy, Dimitri Dobroskok, Yoonsuck Choe, Dimitri Dobroskok, Michael R Nowak, Alexander Lozovskiy, Yoonsuck Choe
Knife-edge scanning microscopy provides the capability to image whole-brain cerebral microvasculature of small organisms, such as mice, at sub-micron resolution, providing a feasible foundation for the reconstruction of circulatory pathways from the systemic to cellular scale. In this paper, we illustrate the feasibility of using this data to model cerebral blood flow using numerical simulations. Starting with a small vascular element in microcirculation of interest, we present its segmentation from the imaging-data volume, construction of its triangular surface mesh, assembly of its tetrahedral volumetric mesh from the surface, and then conclude with Stokes flow simulation of plasma through the microvascular vessel...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227577/blood-perfusion-display-based-on-video-pulse-wave
#17
Makoto Yoshizawa, Norihiro Sugita, Makoto Abe, Akira Tanaka, Kazuma Obara, Tsuyoshi Yamauchi, Noriyasu Homma, Tomoyuki Yambe, Makoto Yoshizawa, Norihiro Sugita, Makoto Abe, Akira Tanaka, Kazuma Obara, Tsuyoshi Yamauchi, Noriyasu Homma, Tomoyuki Yambe, Norihiro Sugita, Noriyasu Homma, Makoto Abe, Kazuma Obara, Tomoyuki Yambe, Makoto Yoshizawa, Akira Tanaka, Tsuyoshi Yamauchi
In this study, an easy system for monitoring dynamic blood perfusion patterns and the pulse wave velocity (PWV) has been developed by processing video images of a human body to assess blood circulation for daily management of physical conditions or for detecting persons in poor physical condition in public places. The experiment suggested that this tool can be used to easily evaluate the PWV; however, the obtained value from the video image of the face was about 1/10 of the standard value calculated from thick vessels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227503/suitability-of-nitinol-electrodes-in-neural-prostheses-such-as-endovascular-neural-interfaces
#18
Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden, Yan T Wong, Nicholas L Opie, Sam E John, Giulia Gerboni, Gil S Rind, Stephen M Ronayne, Kate E Fox, Thomas J Oxley, David B Grayden, Sam E John, Stephen M Ronayne, David B Grayden, Nicholas L Opie, Kate E Fox, Giulia Gerboni, Thomas J Oxley, Yan T Wong, Gil S Rind
A major challenge facing neural prostheses is the development of electrodes that are well tolerated by the brain and body. A novel way to circumvent the need to perform an invasive craniotomy and penetration of the blood-brain barrier to implant electrodes, is to guide electrodes up into the cerebral veins and place electrodes on the vessel walls adjacent to neuronal populations. To aid in the development of these stent based devices, microelectrodes manufactured from Nitinol would allow electrodes to be implanted via a catheter and then once deployed, alter their shape to conform to the vessel walls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227501/feasibility-of-a-chronic-minimally-invasive-endovascular-neural-interface
#19
Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley, Nicholas L Opie, Gil S Rind, Sam E John, Stephen M Ronayne, David B Grayden, Anthony N Burkitt, Clive N May, Terence J O'Brien, Thomas J Oxley, Sam E John, Stephen M Ronayne, David B Grayden, Nicholas L Opie, Anthony N Burkitt, Terence J O'Brien, Clive N May, Thomas J Oxley, Gil S Rind
Development of a neural interface that can be implanted without risky, open brain surgery will increase the safety and viability of chronic neural recording arrays. We have developed a minimally invasive surgical procedure and an endovascular electrode-array that can be delivered to overlie the cortex through blood vessels. Here, we describe feasibility of the endovascular interface through electrode viability, recording potential and safety. Electrochemical impedance spectroscopy demonstrated that electrode impedance was stable over 91 days and low frequency phase could be used to infer electrode incorporation into the vessel wall...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227363/3d-gabor-wavelet-based-vessel-filtering-of-photoacoustic-images
#20
Israr Ul Haq, Ryo Nagoaka, Takahiro Makino, Takuya Tabata, Yoshifumi Saijo, Israr Ul Haq, Ryo Nagoaka, Takahiro Makino, Takuya Tabata, Yoshifumi Saijo, Ryo Nagoaka, Yoshifumi Saijo, Takahiro Makino, Takuya Tabata
Filtering and segmentation of vasculature is an important issue in medical imaging. The visualization of vasculature is crucial for the early diagnosis and therapy in numerous medical applications. This paper investigates the use of Gabor wavelet to enhance the effect of vasculature while eliminating the noise due to size, sensitivity and aperture of the detector in 3D Optical Resolution Photoacoustic Microscopy (OR-PAM). A detailed multi-scale analysis of wavelet filtering and Hessian based method is analyzed for extracting vessels of different sizes since the blood vessels usually vary with in a range of radii...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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