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https://www.readbyqxmd.com/read/29245053/influence-of-diabetes-on-the-foreign-body-response-to-nitric-oxide-releasing-implants
#1
Robert J Soto, Elizabeth P Merricks, Dwight A Bellinger, Timothy C Nichols, Mark H Schoenfisch
The foreign body response (FBR) to nitric oxide (NO)-releasing subcutaneous implants was compared between healthy and streptozotocin-induced diabetic swine by evaluating inflammation, collagen capsule formation, and angiogenesis. Steel wire substrates were first modified with polyurethane membranes capable of diverse NO-release kinetics (NO fluxes and release durations of 0.8-630.0 pmol cm-2 s-1 and 2-13 d, respectively). The NO-releasing materials were implanted in the subcutis for 3, 10, or 25 d for histological and immunohistochemical evaluation of the FBR...
November 30, 2017: Biomaterials
https://www.readbyqxmd.com/read/29244827/neuroligin-4x-overexpression-in-human-breast-cancer-is-associated-with-poor-relapse-free-survival
#2
Henry J Henderson, Balasubramanyam Karanam, Rajeev Samant, Komal Vig, Shree R Singh, Clayton Yates, Deepa Bedi
The molecular mechanisms involved in breast cancer progression and metastasis still remain unclear to date. It is a heterogeneous disease featuring several different phenotypes with consistently different biological characteristics. Neuroligins are neural cell adhesion molecules that have been implicated in heterotopic cell adhesion. In humans, alterations in neuroligin genes are implicated in autism and other cognitive diseases. Until recently, neuroligins have been shown to be abundantly expressed in blood vessels and also play a role implicated in the growth of glioma cells...
2017: PloS One
https://www.readbyqxmd.com/read/29244812/optimal-occlusion-uniformly-partitions-red-blood-cells-fluxes-within-a-microvascular-network
#3
Shyr-Shea Chang, Shenyinying Tu, Kyung In Baek, Andrew Pietersen, Yu-Hsiu Liu, Van M Savage, Sheng-Ping L Hwang, Tzung K Hsiai, Marcus Roper
In animals, gas exchange between blood and tissues occurs in narrow vessels, whose diameter is comparable to that of a red blood cell. Red blood cells must deform to squeeze through these narrow vessels, transiently blocking or occluding the vessels they pass through. Although the dynamics of vessel occlusion have been studied extensively, it remains an open question why microvessels need to be so narrow. We study occlusive dynamics within a model microvascular network: the embryonic zebrafish trunk. We show that pressure feedbacks created when red blood cells enter the finest vessels of the trunk act together to uniformly partition red blood cells through the microvasculature...
December 15, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29244272/comparison-of-perioperative-outcomes-with-or-without-renorrhaphy-during-open-partial-nephrectomy-a-propensity-score-matched-analysis
#4
Hidekazu Tachibana, Toshio Takagi, Tsunenori Kondo, Hideki Ishida, Kazunari Tanabe
PURPOSE: Renorrhaphy in partial nephrectomy may damage intraparenchymal vessels and compress the renal parenchyma, which may lead to the formation of renal artery pseudoaneurysms or vascularized parenchymal volume reduction. Using propensity score matching, we compared surgical outcomes following non-renorrhaphy and renorrhaphy techniques for open partial nephrectomy (OPN) for T1a renal tumors. MATERIALS AND METHODS: We retrospectively analyzed data from 159 patients with normal contralateral kidneys who underwent OPN for T1a renal tumors and pre- and postoperative enhanced computed tomography between 2012 and 2015...
December 18, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29244074/the-heart-regulates-the-endocrine-response-to-heart-failure-cardiac-contribution-to-circulating-neprilysin
#5
Mattia Arrigo, Nicolas Vodovar, Hélène Nougué, Malha Sadoune, Chris J Pemberton, Pamela Ballan, Pierre-Olivier Ludes, Nicolas Gendron, Alain Carpentier, Bernard Cholley, Philippe Bizouarn, Alain Cohen-Solal, Jagmeet P Singh, Jackie Szymonifka, Christian Latremouille, Jane-Lise Samuel, Jean-Marie Launay, Julien Pottecher, A Mark Richards, Quynh A Truong, David M Smadja, Alexandre Mebazaa
Aims: Heart failure (HF) is accompanied by major neuroendocrine changes including the activation of the natriuretic peptide (NP) pathway. Using the unique model of patients undergoing implantation of the CARMAT total artificial heart and investigating regional differences in soluble neprilysin (sNEP) in patients with reduced or preserved systolic function, we studied the regulation of the NP pathway in HF. Methods and results: Venous blood samples from two patients undergoing replacement of the failing ventricles with a total artificial heart were collected before implantation and weekly thereafter until post-operative week 6...
December 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29243981/assessment-of-intracranial-venous-blood-flow-after-subarachnoid-hemorrhage-a-new-approach-to-diagnose-vasospasm-with-transcranial-color-coded-duplex-sonography
#6
Florian Connolly, Stephan J Schreiber, Christoph Leithner, Georg Bohner, Peter Vajkoczy, José M Valdueza
OBJECTIVE Transcranial color-coded duplex sonography (TCCS) is a reliable tool that is used to assess vasospasm in the M1 segment of the middle cerebral artery (MCA) after subarachnoid hemorrhage (SAH). A distinct increase in blood flow velocity (BFV) is the principal criterion for vasospasm. The MCA/internal carotid artery (ICA) index (Lindegaard Index) is also widely used to distinguish between vasospasm and cerebral hyperperfusion. However, extracranial ultrasonography assessment of the neck vessels might be difficult in an intensive care unit...
December 15, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29243788/evaluation-on-the-impact-of-spontaneous-reperfusion-on-cardiac-muscle-of-acute-myocardial-infarction-by-three-dimensional-speckle-tracking-imaging
#7
Z-W Tao, X-W Ma, N-N Liu, N-L Tian, X-F Gao, P-X Xiao
OBJECTIVE: To explore the effect of spontaneous reperfusion (SR) on three-dimensional myocardial strain in patients with acute anterior myocardial infarction by three-dimensional speckle tracking imaging (3D-STI) technology. PATIENTS AND METHODS: Patients diagnosed with acute anterior myocardial infarction during 2013 to 2016 were consecutively selected and divided into SR group and non-spontaneous reperfusion (Non-SR) group based on whether there was SR. Patients in both groups received direct percutaneous coronary intervention (PCI) in time window...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243184/study-of-myb-nfib-chimeric-gene-expression-tumor-angiogenesis-and-proliferation-in-adenoid-cystic-carcinoma-of-salivary-gland
#8
Junya Ono, Yasuo Okada
Adenoid cystic carcinoma (ACC) is one of the common malignant tumors in salivary glands, and the clinical prognosis is poor with frequent distant metastasis which may lead to death. Expression of the MYB-NFIB chimeric gene in ACC has been reported recently. MYB is an oncogene with transcription regulating functions, and NFIB encodes nuclear transcription factor although detailed functions are unknown. This study investigated whether MYB-NFIB chimeric gene expression affects tumor angiogenesis and proliferation in salivary gland ACC...
December 14, 2017: Odontology
https://www.readbyqxmd.com/read/29242821/regulation-of-regeneration-by-heparan-sulfate-proteoglycans-in-the-extracellular-matrix
#9
David M Gardiner
Just as the building of a house requires a blueprint, the rebuilding of lost or damaged body parts through regeneration requires a set of instructions for the assembly of the various tissues into the right places. Much progress has been made in understanding how to control the differentiation of different cell types to provide the building blocks for regeneration, such as bone, muscle, blood vessels and nerves/Schwann cells. These are the cells that follow the blueprint (the pattern-following cells) and end up in the right places relative to each other in order to restore the lost function...
September 2017: Regenerative Engineering and Translational Medicine
https://www.readbyqxmd.com/read/29242801/spindle-cell-hemangioma-of-the-midfoot-a-case-report
#10
Tanawat Vaseenon, Jirawat Saengsin, Nuttaya Pattamapaspong, Jongkolnee Settakorn, Dumnoensun Pruksakorn
Introduction: Spindle cell hemangioma (SCH) of the bone (midfoot) is a rare disease, but it can cause symptomatic pain and invade surrounding tissues lead to limb deformities and functional loss. Case Report: We report the case of a 35-year-old woman who experienced a firm mass over the left midfoot for 5 years causing pain and numbness in the foot. Radiographs showed a geographic osteolytic lesion involving calcification of the base of the 2nd and 3rd metatarsals, cuneiforms bones and surrounding soft tissue...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29242270/intermedin-enlarges-the-vascular-lumen-by-inducing-the-quiescent-endothelial-cell-proliferation
#11
Li-Jun Wang, Fei Xiao, Ling-Miao Kong, De-Nian Wang, Hong-Yu Li, Yong-Gang Wei, Chun Tan, Huan Zhao, Ting Zhang, Gui-Qun Cao, Kang Zhang, Yu-Quan Wei, Han-Shuo Yang, Wei Zhang
OBJECTIVE: Intermedin plays an important role in vascular remodeling and significantly improves blood perfusion, but the precise mechanism remains unclear. Herein, we aimed to define whether vascular lumen enlargement is responsible for the intermedin-increased blood perfusion and explore the underlying cellular and molecular mechanisms. APPROACH AND RESULTS: To study the role of intermedin, we generated the IMD-KO (Adm2-/-) mice using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-associated 9) system...
December 14, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29242199/organ-specific-lymphatic-vasculature-from-development-to-pathophysiology
#12
REVIEW
Tatiana V Petrova, Gou Young Koh
Recent discoveries of novel functions and diverse origins of lymphatic vessels have drastically changed our view of lymphatic vasculature. Traditionally regarded as passive conduits for fluid and immune cells, lymphatic vessels now emerge as active, tissue-specific players in major physiological and pathophysiological processes. Lymphatic vessels show remarkable plasticity and heterogeneity, reflecting their functional specialization to control the tissue microenvironment. Moreover, alternative developmental origins of lymphatic endothelial cells in some organs may contribute to the diversity of their functions in adult tissues...
December 14, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29242161/preparation-of-dexamethasone-loaded-biphasic-calcium-phosphate-nanoparticles-collagen-porous-composite-scaffolds-for-bone-tissue-engineering
#13
Ying Chen, Naoki Kawazoe, Guoping Chen
Although bone is regenerative, its regeneration capacity is limited. For bone defects beyond a critical size, further intervention is required. As an attractive strategy, bone tissue engineering (bone TE) has been widely investigated to repair bone defects. However, the rapid and effective bone regeneration of large non-healing defects is still a great challenge. Multifunctional scaffolds having osteoinductivity and osteoconductivity are desirable to fasten functional bone tissue regeneration. In the present study, biomimetic composite scaffolds of collagen and biphasic calcium phosphate nanoparticles (BCP NPs) with a controlled release of dexamethasone (DEX) and the controlled pore structures were prepared for bone TE...
December 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29242144/recent-advances-in-understanding-the-roles-of-blood-platelets-in-the-pathogenesis-of-allergic-inflammation-and-bronchial-asthma
#14
REVIEW
Tomohiro Takeda, Hideaki Morita, Hirohisa Saito, Kenji Matsumoto, Akio Matsuda
Platelets play an essential role in hemostasis to minimize blood loss due to traumatic injury. In addition, they contain various immune-associated molecules and contribute to immunological barrier formation at sites of vascular injury, thereby protecting against invading pathogens. Platelets are also crucially involved in development of allergic diseases, including bronchial asthma. Platelets in asthmatics are more activated than those in healthy individuals. By using a murine asthma model, platelets were shown to be actively involved in progression of the disease, including in airway eosinophilia and airway remodeling...
December 11, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29242099/downregulation-of-circulating-mots-c-levels-in-patients-with-coronary-endothelial-dysfunction
#15
Qing Qin, Silvia Delrio, Junxiang Wan, R Jay Widmer, Pinchas Cohen, Lilach O Lerman, Amir Lerman
BACKGROUND: MOTS-c is one of the newly identified mitochondrial-derived peptides which play a role in regulating metabolic homeostasis. The current study aimed to investigate whether circulating MOTS-c levels are also associated with endothelial dysfunction(ED) in patients without significant structural coronary lesions. METHODS: Forty patients undergoing coronary angiography and endothelial function testing for clinical indications of recurrent angina with no structural coronary lesions were included in the study...
December 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29242072/therapeutic-angiogenesis-by-local-sustained-release-of-microrna-126-using-poly-lactic-co-glycolic-acid-nanoparticles-in-murine-hindlimb-ischemia
#16
Shinichi Tsumaru, Hidetoshi Masumoto, Kenji Minakata, Masayasu Izuhara, Kazuhiro Yamazaki, Tadashi Ikeda, Koh Ono, Ryuzo Sakata, Kenji Minatoya
OBJECTIVE: Recent studies demonstrate that microRNAs show promising potential, including angiogenesis, in therapeutic intervention. MicroRNA-126 (miR-126) is reported to regulate angiogenesis by blocking Sprouty-related EVH1 domain-containing protein 1 (SPRED1), an endogenous inhibitor of vascular endothelial cell growth factor. In this study, we investigated the angiogenic effects of the sustained release of miR-126 loaded with poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) in a murine hindlimb ischemia model...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29241963/negative-pressure-wound-therapy-in-pediatric-surgery-how-and-when-to-use
#17
REVIEW
Lisieux Eyer de Jesus, Alana Bandeira Martins, Pablo Baptista Oliveira, Fernanda Gomes, Thais Leve, Samuel Dekermacher
INTRODUCTION: Negative pressure wound therapy (NPWT) has been widely adopted to treat laparostomy, abdominal compartment syndrome (ACS) and complicated wounds associated with tissue loss. The method presents specific aspects, advantages and indications in Pediatrics. Our aim is to review the evidence available about NPWT in children. METHODS: Active search for papers about NPWT in Pediatric patients. Papers referring to orthopedic problems, wound complications after Cardiac Surgery or burns were excluded...
November 21, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29241208/exosomes-from-mir-126-overexpressing-adscs-are-therapeutic-in-relieving-acute-myocardial-ischaemic-injury
#18
Qiancheng Luo, Dongfeng Guo, Guorong Liu, Guo Chen, Min Hang, Mingming Jin
BACKGROUND/AIMS: Recent studies have indicated that exosomes play an important role in adipose-derived stem cell (ADSC) transplant-mediated ischaemic heart disease therapy. However, the treatment effect is not obvious. The aim of this study is to investigate whether ADSC-derived exosomes enriched with microRNA (miR)-126 have a more protective effect on acute myocardial infarction (AMI). METHODS: Exosomes were characterized by transmission electron microscopy, and the exosome particles were further examined using nanoparticle tracking analyses...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241032/biomimetic-elastomeric-conductive-and-biodegradable-polycitrate-based-nanocomposites-for-guiding-myogenic-differentiation-and-skeletal-muscle-regeneration
#19
Yuzhang Du, Juan Ge, Yannan Li, Peter X Ma, Bo Lei
Artificial muscle-like biomaterials have gained tremendous interests owing to their broad applications in regenerative medicine, wearable devices, bioelectronics and artificial intelligence. Unfortunately, key challenges are still existed for current materials, including biomimetic viscoelasticity, biocompatibility and biodegradation, multifunctionality. Herein, for the first time, we develop highly elastomeric, conductive and biodegradable poly (citric acid-octanediol-polyethylene glycol)(PCE)-graphene (PCEG) nanocomposites, and demonstrate their applications in myogenic differentiation and guiding skeletal muscle tissue regeneration...
December 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29240251/progenitor-cells-from-different-zones-of-human-cartilage-and-their-correlation-with-histopathological-osteoarthritis-progression
#20
V P Mantripragada, W A Bova, C Boehm, N S Piuzzi, N A Obuchowski, R J Midura, G F Muschler
Cell-based therapies development for the treatment of osteoarthritis (OA) requires an understanding of the disease progression and attributes of the cells resident in cartilage. This study focused on quantitative assessment of the concentration and biological potential of stem and progenitor cells resident in different zones of cartilage displaying macroscopic Outerbridge grade 1-2 OA, and their correlation with OA progression based on established histologic scoring system. Lateral femoral condyles were collected from fifteen patients with idiopathic OA and varus knees undergoing total knee arthroplasty...
December 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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