keyword
https://read.qxmd.com/read/38536994/injectable-platelet-rich-fibrin-effect-on-laser-depigmented-gingiva-a-clinical-randomized-controlled-split-mouth-trial-with-histological-assessment
#1
JOURNAL ARTICLE
Suzan Seif Allah Ibrahim, Ibrahim Abu Mandil, Ola Mohamed Ezzatt
OBJECTIVE: To determine whether intra-mucosal injection of injectable platelet-rich fibrin (i-PRF) can promote healing after Diode Laser Gingival Depigmentation (DLGD). METHODOLOGY: A total of 20 arch sites of hyperpigmented gingiva of 10 patients underwent DLGD. For each patient, two arch sites were randomly assigned for either intra-mucosal injection of i-PRF (G1-i-PRF) (n=10 sites) or no treatment (G2-Control): (n=10 sites). Wound Healing Score (WHS), patient satisfaction, and Pigmentation Index (DOPI) were measured at 1 week and 1 and 3 months postoperatively...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536861/predictors-for-participation-in-mass-treatment-and-female-genital-schistosomiasis-re-investigation-and-the-effect-of-praziquantel-treatment-in-south-african-adolescents
#2
JOURNAL ARTICLE
Takalani Girly Nemungadi, Elisabeth Kleppa, Hashini Nilushika Galappaththi-Arachchige, Pavitra Pillay, Svein Gunnar Gundersen, Birgitte Jyding Vennervald, Patricia Doris Ndhlovu, Myra Taylor, Saloshni Naidoo, Eyrun Floerecke Kjetland
OBJECTIVE: Female Genital Schistosomiasis (FGS) causes intravaginal lesions and symptoms that could be mistaken for sexually transmitted diseases or cancer. In adults, FGS lesions [grainy sandy patches (GSP), homogenous yellow patches (HYP), abnormal blood vessels and rubbery papules] are refractory to treatment. The effect of treatment has never been explored in young women; it is unclear if gynaecological investigation will be possible in this young age group (16-23 years). We explored the predictors for accepting anti-schistosomal treatment and/or gynaecological reinvestigation in young women, and the effects of anti-schistosomal mass-treatment (praziquantel) on the clinical manifestations of FGS at an adolescent age...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536816/iqgap1-and-nwasp-promote-human-cancer-cell-dissemination-and-metastasis-by-regulating-%C3%AE-1-integrin-via-fak-and-mrtf-srf
#3
JOURNAL ARTICLE
Camilla Cerutti, Serena Lucotti, Sofia T Menendez, Nicolas Reymond, Ritu Garg, Ignacio A Romero, Ruth Muschel, Anne J Ridley
Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536760/nonpharmacologic-rate-control-of-postoperative-atrial-fibrillation-in-the-canine-sterile-pericarditis-model
#4
JOURNAL ARTICLE
Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan
INTRODUCTION: Postoperative atrial fibrillation (POAF) is common following open heart surgery, and is associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid ventricular rates during the postoperative period because of increased sympathetic tone. The purpose of this study was to develop nonpharmacologic rate control of POAF by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires in the canine sterile pericarditis model...
March 27, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38536758/intimate-contact-between-red-blood-cells-and-vessel-walls-is-sufficient-to-stabilize-capillary-networks-during-development
#5
COMMENT
Sylvie Lorthois
No abstract text is available yet for this article.
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536487/peripheral-blood-syndecan-1-levels-after-mechanical-thrombectomy-can-predict-the-clinical-prognosis-of-patients-with-acute-ischemic-stroke
#6
JOURNAL ARTICLE
Bin Xu, Tengkun Yin, Tanggui Sun, Zhongchen Li, Zhiyuan Zhang, Hang Lv, Chonghui Tian, Jiyue Wang, Jiheng Hao, Liyong Zhang
BACKGROUND: Previously, we revealed noticeable dynamic fluctuations in syndecan-1 levels in the peripheral blood of post-stroke patients. We further investigated the clinical prognostic value of syndecan-1 as a biomarker of glycoprotein damage in patients with acute ischaemic stroke (AIS). METHODS: We examined 105 patients with acute large vessel occlusion in the anterior circulation, all of whom underwent mechanical thrombectomy (MT). Peripheral blood syndecan-1 levels were measured 1 day after MT, and patients were categorised into favourable and unfavourable prognostic groups based on the 90-day modified Rankin Scale (mRS) score...
March 27, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38535794/the-role-of-snake-venom-disintegrins-in-angiogenesis
#7
REVIEW
Patricia Bianca Clissa, Maisa Splendore Della-Casa, Bianca Cestari Zychar, Sabri Saeed Sanabani
Angiogenesis, the formation of new blood vessels, plays a critical role in various physiological and pathological conditions. Snake venom disintegrins (SVDs) have been identified as significant regulators of this process. In this review, we explore the dual roles of SVD in angiogenesis, both as antiangiogenic agents by inhibiting integrin binding and interfering with vascular endothelial growth factors and as proangiogenic agents by enhancing integrin binding, stimulating cell migration and proliferation, and inducing neoangiogenesis...
March 1, 2024: Toxins
https://read.qxmd.com/read/38535138/an-improved-path-finding-method-for-the-tracking-of-centerlines-of-tortuous-internal-carotid-arteries-in-mr-angiography
#8
JOURNAL ARTICLE
Se-On Kim, Yoon-Chul Kim
Centerline tracking is useful in performing segmental analysis of vessel tortuosity in angiography data. However, a highly tortuous) artery can produce multiple centerlines due to over-segmentation of the artery, resulting in inaccurate path-finding results when using the shortest path-finding algorithm. In this study, the internal carotid arteries (ICAs) from three-dimensional (3D) time-of-flight magnetic resonance angiography (TOF MRA) data were used to demonstrate the effectiveness of a new path-finding method...
February 28, 2024: Journal of Imaging
https://read.qxmd.com/read/38534972/pediatric-hemangiomas-in-the-female-genital-tract-a-literature-review
#9
REVIEW
Lucia Merlino, Agnese Immacolata Volpicelli, Franco Anglana, Giulia D'Ovidio, Mattia Dominoni, Marianna Francesca Pasquali, Barbara Gardella, Paolo Inghirami, Pietro Lippa, Roberto Senatori
BACKGROUND: Hemangiomas are aberrant proliferations of blood vessels and the most frequent benign pediatric soft tissue tumors. Although they are common, genital localization is rare. This study aimed to assist doctors in the diagnosis, management, and treatment of pediatric vulvovaginal hemangiomas by conducting a review of the literature. METHODS: We conducted a literature review including papers published between August 2009 and May 2023. RESULTS: While most hemangiomas are usually indolent and resolve with time, in some cases, especially cervicovaginal and uterine ones, they might present with severe symptoms like heavy bleeding and need further instrumental investigation for diagnosis, like CT or MRI...
February 28, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534854/review-of-spider-silk-applications-in-biomedical-and-tissue-engineering
#10
REVIEW
Marija Branković, Fatima Zivic, Nenad Grujovic, Ivan Stojadinovic, Strahinja Milenkovic, Nikola Kotorcevic
This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems...
March 11, 2024: Biomimetics
https://read.qxmd.com/read/38534749/melanocortin-derivatives-induced-vascularization-and-neuroglial-proliferation-in-the-rat-brain-under-conditions-of-cerebral-ischemia
#11
JOURNAL ARTICLE
Vasily V Stavchansky, Vadim V Yuzhakov, Larisa E Sevan'kaeva, Natalia K Fomina, Anastasia E Koretskaya, Alina E Denisova, Ivan V Mozgovoy, Leonid V Gubsky, Ivan B Filippenkov, Nikolay F Myasoedov, Svetlana A Limborska, Lyudmila V Dergunova
Stroke remains the second leading cause of death worldwide. The development of new therapeutic agents focused on restoring vascular function and neuroprotection of viable tissues is required. In this study the neuroprotective activity of melanocortin-like ACTH(4-7)PGP and ACTH(6-9)PGP peptides was investigated in rat brain at 24 h after transient middle cerebral artery occlusion (tMCAO). The severity of ischemic damage, changes in the proliferative activity of neuroglial cells and vascularization of rat brain tissue were analyzed...
March 5, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534561/the-impact-of-defect-size-on-bone-healing-in-critical-size-bone-defects-investigated-on-a-rat-femur-defect-model-comparing-two-treatment-methods
#12
JOURNAL ARTICLE
Andreas Kammerer, Frederik Alexander Hartmann, Christoph Nau, Maximilian Leiblein, Alexander Schaible, Jonas Neijhoft, Dirk Henrich, René Verboket, Maren Janko
Critical-size bone defects up to 25 cm can be treated successfully using the induced membrane technique established by Masquelet. To shorten this procedure, human acellular dermis (HAD) has had success in replacing this membrane in rat models. The aim of this study was to compare bone healing for smaller and larger defects using an induced membrane and HAD in a rat model. Using our established femoral defect model in rats, the animals were placed into four groups and defects of 5 mm or 10 mm size were set, either filling them with autologous spongiosa and surrounding the defect with HAD or waiting for the induced membrane to form around a cement spacer and filling this cavity in a second operation with a cancellous bone graft...
March 19, 2024: Bioengineering
https://read.qxmd.com/read/38534477/carotid-artery-bypass-surgery-of-in-body-tissue-architecture-induced-small-diameter-biotube-in-a-goat-model-a-pilot-study
#13
JOURNAL ARTICLE
Tadashi Umeno, Kazuki Mori, Ryosuke Iwai, Takayuki Kawashima, Takashi Shuto, Yumiko Nakashima, Tsutomu Tajikawa, Yasuhide Nakayama, Shinji Miyamoto
Biotubes are autologous tubular tissues developed within a patient's body through in-body tissue architecture, and they demonstrate high potential for early clinical application as a vascular replacement. In this pilot study, we used large animals to perform implantation experiments in preparation for preclinical testing of Biotube. The biological response after Biotube implantation was histologically evaluated. The designed Biotubes (length: 50 cm, internal diameter: 4 mm, and wall thickness: 0.85 mm) were obtained by embedding molds on the backs of six goats for a predetermined period (1-5 months)...
February 21, 2024: Bioengineering
https://read.qxmd.com/read/38534342/a-recombinant-peptide-device-combined-with-adipose-tissue-derived-stem-cells-enhances-subcutaneous-islet-engraftment
#14
JOURNAL ARTICLE
Takahiro Mizui, Akiko Inagaki, Yasuhiro Nakamura, Takehiro Imura, Satomi Suzuki Uematsu, Shigehito Miyagi, Takashi Kamei, Michiaki Unno, Kimiko Watanabe, Masafumi Goto
Subcutaneous space has been considered an attractive site for islet graft transplantation; however, the oxygen tension and vascularization are insufficient for islet graft survival. We investigated whether subcutaneous pre-implantation of a recombinant peptide (RCP) device with adipose tissue-derived stem cells (ADSCs) enhanced subcutaneous islet engraftment. RCP devices with/without syngeneic ADSCs were pre-implanted into the subcutaneous space of C57BL/6 mice. Syngeneic islets (300 or 120 islet equivalents (IEQs)) were transplanted into the pre-treated space after diabetes induction using streptozotocin...
March 13, 2024: Cells
https://read.qxmd.com/read/38534331/low-density-lipoprotein-cholesterol-decreases-the-expression-of-adenosine-a-2a-receptor-and-lipid-rafts-protein-flotillin-1-insights-on-cardiovascular-risk-of-hypercholesterolemia
#15
JOURNAL ARTICLE
Marie-Charlotte Chaptal, Marie Maraninchi, Giorgia Musto, Julien Mancini, Hedi Chtioui, Janine Dupont-Roussel, Marion Marlinge, Julien Fromonot, Nathalie Lalevee, Florian Mourre, Sophie Beliard, Régis Guieu, René Valero, Giovanna Mottola
High blood levels of low-density lipoprotein (LDL)-cholesterol (LDL-C) are associated with atherosclerosis, mainly by promoting foam cell accumulation in vessels. As cholesterol is an essential component of cell plasma membranes and a regulator of several signaling pathways, LDL-C excess may have wider cardiovascular toxicity. We examined, in untreated hypercholesterolemia (HC) patients, selected regardless of the cause of LDL-C accumulation, and in healthy participants (HP), the expression of the adenosine A2A receptor (A2A R), an anti-inflammatory and vasodilatory protein with cholesterol-dependent modulation, and Flotillin-1, protein marker of cholesterol-enriched plasma membrane domains...
March 11, 2024: Cells
https://read.qxmd.com/read/38534205/meningeal-damage-and-interface-astroglial-scarring-in-the-rat-brain-exposed-to-a-laser-induced-shock-wave-s
#16
JOURNAL ARTICLE
Satoko Kawauchi, Akemi Kono, Yuriko Muramatsu, Grant Hennes, Shuta Seki, Susumu Tominaga, Yasue Haruyama, Yukari Komuta, Izumi Nishidate, Susumu Matsukuma, Yushan Wang, Shunichi Sato
In the past decade, signature clinical neuropathology of blast-induced traumatic brain injury has been under intense debate, but interface astroglial scarring (IAS) seems to be convincing. In this study, we examined whether IAS could be replicated in the rat brain exposed to a laser-induced shock wave(s) (LISW[s]), a tool that can produce a pure shock wave (primary mechanism) without dynamic pressure (tertiary mechanism). Under certain conditions, we observed astroglial scarring in the subpial glial plate (SGP), grey-white matter junctions (GM-WM), ventricular wall (VW) and regions surrounding cortical blood vessels, accurately reproducing clinical IAS...
March 27, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38534025/vascular-stenting-of-a-malignant-arterial-blowout-as-a-bridge-to-effective-systemic-and-regional-therapy
#17
Taylor P Williams, Mitchell W Cox, Bagi Jana, Merrick I Ross, Sarah B Fisher, John P Walker, Celyne B Hume, Lauren L Mayo, Douglas S Tyler
Locally advanced cutaneous squamous cell carcinoma can erode into blood vessels, leading to vascular blowout, requiring emergent surgical intervention. We describe a first case of this disease complication which was effectively managed with endovascular stenting as a bridge to effective systemic and regional therapy. We discuss the efficacy of this staged approach which is novel and timely in a clinical environment of increasingly effective systemic therapies.
March 27, 2024: Journal of Surgical Oncology
https://read.qxmd.com/read/38534012/feasibility-of-a-novel-atrial-mechanical-sensing-method-for-leadless-atrioventricular-synchronous-pacing
#18
JOURNAL ARTICLE
Shuichiro Kazawa, Chifumi Kazawa, Tomoko Sakaida, Hidetaka Murakami, Yasuyuki Takada, Takahiro Kusume, Muryo Terasawa, Nobuhiro Tanaka, Kazuhiro Satomi, Yoshinao Yazaki
INTRODUCTION: Few studies have demonstrated a high degree of atrioventricular (AV) synchrony with a new leadless pacemaker called Micra AV. Our group previously reported a new and unique sensing method. We believe that this novel sensing method, "Simplified A3 method," might facilitate better AV synchrony than a conventional sensing method in almost all cases with Micra AV implantation. METHODS: We conducted a non-randomized retrospective study comparing the two pacing methods at two centers...
March 27, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38534004/first-in-man-right-atrial-appendage-implantation-of-a-micra-leadless-pacemaker
#19
Pauline Pinon, Laurence Iserin, Fatma Hachem, Victor Waldmann
INTRODUCTION: Pacemaker implantation can be challenging in patients with congenital heart disease. METHODS AND RESULTS: In a patient with Ebstein disease and symptomatic sinus node dysfunction, despite multiple attempts, the Micra® pacemaker could not be implanted in the severely dilated right ventricle. In that context, and after iodine injection to confirm the appropriate location, the Micra® pacemaker was successfully implanted in the right appendage at the first attempt...
March 27, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38533955/deviation-from-personalized-blood-pressure-targets-correlates-with-worse-outcome-after-successful-recanalization
#20
JOURNAL ARTICLE
Zhe Zhang, Yuehua Pu, Lei Yu, Haiwei Bai, Wanying Duan, Xin Liu, Ximing Nie, Zhixuan Wen, Lina Zheng, Xiao Hu, Xinyi Leng, Yuesong Pan, Nils H Petersen, Liping Liu
BACKGROUND: Personalized blood pressure (BP) management for patients with acute ischemic stroke after successful endovascular thrombectomy lacks evidence. We aimed to investigate whether the deviation of BP from cerebral autoregulation limits is associated with worse outcomes. METHODS AND RESULTS: We determined autoregulation by measuring mean velocity index and calculated the percentage of time and the burden (defined as the time-BP area) with BP outside the autoregulatory limits of each subject within 48 hours after endovascular thrombectomy...
March 27, 2024: Journal of the American Heart Association
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