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https://www.readbyqxmd.com/read/29679722/pulmonary-lymphatic-vessel-morphology-a-review
#1
REVIEW
E Weber, F Sozio, A Borghini, P Sestini, E Renzoni
Our understanding of lymphatic vessels has been advanced by the recent identification of relatively specific lymphatic endothelium markers, including Prox-1, VEGFR3, podoplanin and LYVE-1. The use of lymphatic markers has led to the observation that, contrary to previous assumptions, human lymphatic vessels extend deep inside the pulmonary lobule, either in association with bronchioles, intralobular arterioles or small pulmonary veins. Pulmonary lymphatic vessels may thus be classified into pleural, interlobular (in interlobular septa) and intralobular...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29679616/early-detection-of-diabetic-retinopathy
#2
REVIEW
Hamid Safi, Sare Safi, Ali Hafezi-Moghadam, Hamid Ahmadieh
Diabetic retinopathy (DR) is a primary cause of visual impairment worldwide. Diabetes mellitus may be associated with ophthalmoscopically nonvisible neurovascular damage that progresses before the first clinical signs of DR appear. Reduction of the inner neuroretinal layer thickness on macular optical coherence tomography (OCT), reduced contrast sensitivity primarily at low spatial frequencies, abnormal results in color vision and microperimetry tests, and a prolonged implicit time recorded by multifocal electroretinography have been proposed for detection of early functional and nonvisible structural neuroretinal changes...
April 18, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29679496/detection-of-bone-marrow-derived-fibrocytes-in-human-dental-pulp-repair
#3
N Yoshiba, N Edanami, A Tohma, R Takeuchi, N Ohkura, A Hosoya, Y Noiri, H Nakamura, K Yoshiba
AIM: To explore the expression profile of CD45+/pro-collagen I+ fibrocytes in intact dental pulps as well as during wound healing in adult dental pulp tissue. METHODOLOGY: A total of 16 healthy permanent teeth were obtained from young patients (18 to 25 years) undergoing orthodontic treatment. Routine pulp capping with mineral trioxide aggregate (MTA) was performed under local anaesthesia to induce a mineralized barrier at the exposed surface. Teeth were extracted from patients after 7, 14, and 35 days...
April 21, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29679329/crimped-electrospun-fibers-for-tissue-engineering
#4
Pen-Hsiu Grace Chao
Collagen fibers exist in many parts of the body as parallel bundles with a wavy morphology, known as crimp. This crimp structure contributes to the nonlinear mechanical properties of the tissue, such as ligament, blood vessels, and intestine, which provide elasticity and prevent injury. To recapitulate the native collagen crimp structure, we report a robust method using electrospinning and post-processing to generate parallel polymeric fibers with crimp that simulate the structure-function relationship of native tissue mechanics...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29678936/effect-of-stroke-thrombolysis-predicted-by-distal-vessel-occlusion-detection
#5
Wolfgang G Kunz, Matthias P Fabritius, Wieland H Sommer, Christopher Höhne, Pierre Scheffler, Lukas T Rotkopf, Wolfgang P Fendler, Bastian O Sabel, Felix G Meinel, Franziska Dorn, Birgit Ertl-Wagner, Maximilian F Reiser, Kolja M Thierfelder
OBJECTIVE: Among ischemic stroke patients with negative CT angiography (CTA), we aimed to determine the predictive value of enhanced distal vessel occlusion detection using CT perfusion postprocessing (waveletCTA) for the treatment effect of IV thrombolysis (IVT). METHODS: Patients were selected from 1,851 consecutive patients who had undergone CT perfusion. Inclusion criteria were (1) significant cerebral blood flow (CBF) deficit, (2) no occlusion on CTA, and (3) infarction confirmed on follow-up...
April 20, 2018: Neurology
https://www.readbyqxmd.com/read/29678818/angiolymphoid-hyperplasia-of-external-ear-treated-with-intralesional-radiofrequency-ablation
#6
Deepika Yadav, Sanjay Singh, Neetu Bhari, Somesh Gupta
A 21-year-old woman presented with multiple erythematous to skin-coloured dome-shaped firm papules and plaques over the right ear concha and external auditory canal for 1 year. It was associated with occasional itching and bleeding. Her main concern was cosmetic disfigurement. Biopsy showed presence of multiple proliferating blood vessels lined by plump epithelioid endothelial cells surrounded by dense infiltrate of lymphocytes, histiocytes and eosinophils. Other routine investigations were within normal limits...
April 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29678689/using-high-resolution-x-ray-computed-tomography-to-create-an-image-based-model-of-a-lymph-node
#7
L J Cooper, B Zeller-Plumhoff, G F Clough, B Ganapathisubramani, T Roose
Lymph nodes are an important part of the immune system. They filter the lymphatic fluid as it is transported from the tissues before being returned to the blood stream. The fluid flow through the nodes influences the behaviour of the immune cells that gather within the nodes and the structure of the node itself. Measuring the fluid flow in lymph nodes experimentally is challenging due to their small size and fragility. In this paper, we present high resolution X-ray computed tomography images of a murine lymph node...
April 17, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29678305/the-effect-of-cilostazol-a-phosphodiesterase-3-pde3-inhibitor-on-human-hair-growth-with-the-dual-promoting-mechanisms
#8
Hye-In Choi, Dong Young Kim, Soon-Jin Choi, Chang-Yup Shin, Sungjoo Tommy Hwang, Kyu Han Kim, Ohsang Kwon
BACKGROUND: Cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, increases the intracellular level of cyclic adenosine monophosphate to cause vasodilation. Topical application of cilostazol is reported to improve local blood flow and enhance wound healing; however, its effect on human hair follicles is unknown. OBJECTIVE: The purpose of this study was to determine the effect of cilostazol on hair growth. METHODS: We investigated the expression of PDE3 in human dermal papilla cells (DPCs), outer root sheath cells (ORSCs), and hair follicles...
April 11, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29677767/effect-of-substrate-roughness-on-adhesion-and-structural-properties-of-ti-ni-shape-memory-alloy-thin-film
#9
Donghwan Kim, Hyunsuk Lee, Joohyeon Bae, Hyomin Jeong, Byeongkeun Choi, Taehyun Nam, Jungpil Noh
Ti-Ni shape memory alloy (SMA) thin films are very attractive material for industrial and medical applications such as micro-actuator, micro-sensors, and stents for blood vessels. An important property besides shape memory effect in the application of SMA thin films is the adhesion between the film and the substrate. When using thin films as micro-actuators or micro-sensors in MEMS, the film must be strongly adhered to the substrate. On the other hand, when using SMA thin films in medical devices such as stents, the deposited alloy thin film must be easily separable from the substrate for efficient processing...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677525/insights-from-diversified-anti-angiogenic-models-role-of-%C3%AE-interferon-inducer-deae-dextran
#10
Anita K Bakrania, Bhavesh C Variya, Snehal S Patel
BACKGROUND: Angiogenesis, the physiological process involving growth of new blood vessels from preexisting vessels, is essential for organ growth and repair. However, the imbalance in angiogenesis contributes to copious pathologies including cancer. Preceding the development of anti-angiogenic or proangiogenic agents, its evaluation is equally imperative; hence, precise and adequate models required. Valid mammalian models are expensive, time-consuming and not easy to set up, instigating legal and ethical aspects making it necessary to establish models with satisfactory activity and limited drawbacks...
April 17, 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29677505/a-mechanosensitive-gpcr-that-detects-the-bloody-force
#11
Adam J Iliff, X Z Shawn Xu
Mechanoreceptors mediate a wide variety of physiological processes, such as hearing, touch, proprioception, and blood flow regulation. It is generally believed that mechanoreceptors are force-gated ion channels. Now, Xu et al. uncover a GPCR that is activated by shear force in endothelial cells of blood vessels.
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29677060/cerebral-small-vessel-but-not-large-vessel-disease-is-associated-with-impaired-cerebral-autoregulation-during-cardiopulmonary-bypass-a-retrospective-cohort-study
#12
Yohei Nomura, Roland Faegle, Daijiro Hori, Abbas Al-Qamari, Alexander J Nemeth, Rebecca Gottesman, Gayane Yenokyan, Charles Brown, Charles W Hogue
BACKGROUND: Impaired cerebral blood flow (CBF) autoregulation during cardiopulmonary bypass (CPB) is associated with stroke and other adverse outcomes. Large and small arterial stenosis is prevalent in patients undergoing cardiac surgery. We hypothesize that large and/or small vessel cerebral arterial disease is associated with impaired cerebral autoregulation during CPB. METHODS: A retrospective cohort analysis of data from 346 patients undergoing cardiac surgery with CPB enrolled in an ongoing prospectively randomized clinical trial of autoregulation monitoring were evaluated...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29677054/effects-of-acute-aerobic-exercise-on-arterial-stiffness-and-cerebrovascular-pulsatility-in-adults-with-and-without-hypertension
#13
Wesley K Lefferts, Jacob P DeBlois, Candace N Receno, Tiago V Barreira, Tom D Brutsaert, Robert L Carhart, Kevin S Heffernan
OBJECTIVES: Stiffer central arteries, as seen in hypertension (HTN), foster transmission of pulsatile hemodynamics into fragile cerebral vessels. Aerobic exercise is recommended for adults with HTN, but its effects on arterial stiffness and pulsatility in this group are unclear. This study sought to investigate the effect of acute aerobic exercise on arterial stiffness and cerebrovascular pulsatility in 30 adults with treated HTN and 30 age, sex, and BMI-matched adults without HTN (56 ± 6 years, BMI 28...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29676699/everted-suturing-of-the-inferior-vena-cava-is-addressed-in-the-abdominal-mouse-heart-transplant-model
#14
Hui Ren, Jiabin Zhang, Hongbo Wang, Shaotang Zhou
OBJECTIVES: Our objective was to investigate the techniques of vessel suturing in the abdominal mouse cardiac transplant model and animal outcomes. MATERIALS AND METHODS: Our mouse group included 92 female inbred mice, in which 46 abdominal mouse heart transplants were performed. During transplant, the openings for the aorta and the inferior vena cava were not parallel. With everted anastomosis, the ascending aortae and the pulmonary arteries of donors were connected to the abdominal aortae and interior vena cavae of recipients, respectively, with 11-0 Prolene suture...
April 20, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29676644/air-pollution-exposure-with-fine-dust-responses-in-the-pulmonary-vasculature-and-the-right-heart
#15
Nedim Durmus, Gabriele Grunig
Detrimental effects of air pollution with fine dust (particulate matter ≤2.5 μm in aerodynamic diameter, or PM2.5 ) on the systemic circulation and the left heart have been studied intensely during the past decade. In comparison, knowledge regarding the effects of exposure to air pollution with PM2.5 on the pulmonary vasculature and the right heart lags far behind. A report on severe lung disease and right heart failure in coal miners was published nearly 170 years ago. However, today, we still do not have a clear picture of how the effect of air pollution on the pulmonary circulation or the right heart should be viewed from a clinical, mechanistic biological, therapeutic, or economic angle...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676329/optic-nerve-aplasia-a-case-series
#16
K Samyukta Sadasivan, Neelam Pawar, Meenakshi Ravindran, Ramakrishnan Rengappa
Optic nerve aplasia (ONA) is a congenital optic nerve anomaly characterized by the absence of optic nerve head, retinal blood vessels, retinal ganglion cells, and optic nerve fibers in a malformed eye. Clinically, the condition presents with the absence of perception of light, afferent pupillary defect and a fundus appearance of absent optic nerve head, and retinal vessels with associated ocular and nonocular abnormalities. Systemic anomalies have been reported with bilateral ONA, whereas unilateral ONA is seen in otherwise healthy individuals...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676239/transdermal-delivery-of-at1-receptor-antagonists-reduce-blood-pressure-and-reveals-a-vasodilatory-effect-in-kidney-blood-vessels
#17
Vasso Apostolopoulos, Michaila Michalatou, Maria-Eleni Androutsou, Markos Antonopoulos, George Agelis, Anthony Zulli, Tawar Qaradakhi, John Matsoukas
BACKGROUND: The Renin Angiotensin System (RAS) is pharmacologically targeted to reduce blood pressure, and patient compliance to oral medications is a clinical issue. The mechanisms of action of angiotensin receptor blockers (ARBs) in reducing blood pressure are not well understood, and is purported to be via a reduction of angiotensin II signaling. OBJECTIVE: We aimed to develop a transdermal delivery method for ARBs (losartan potassium and valsartan) and to determine if ARBs reveal a vasodilatory effect of the novel RAS peptide, alamandine...
April 19, 2018: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/29676206/fabrication-of-vascularized-bone-flaps-with-sustained-release-of-rhbmp-2-and-arteriovenous-bundle
#18
Bo Li, Changshun Ruan, Yufei Ma, Zhifeng Huang, Zhenfei Huang, Gang Zhou, Jing Zhang, Hai Wang, Zhihong Wu, Guixing Qiu
INTRODUCTION: It is a common treatment strategy in the clinic to transplant a vascularized bone flap for a large bone defect. But it is difficult for peripheral blood vessels to grow into the central region of a large bone construct. In this study, we fabricated a vascularized bone flap from a 3D-printed biodegradable PLGA/β-TCP scaffold using the combination of an arteriovenous (AV) bundle and recombinant human bone morphogenetic protein-2 (rhBMP-2). MATERIALS AND METHODS: A degradable porous poly (lactide-co-glycolide) /-tri-calcium phosphate (PLGA/β-TCP) scaffold was prepared by adopting 3D plotting and a low-temperature deposition technique...
April 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29676178/afm-as-a-tool-to-evaluate-the-risk-for-cardiovascular-diseases-in-patients
#19
Ana Filipa Guedes, Luís Sargento, José Braz-Nogueira, Nuno Lousada, Carlos Moreira, Filomena A Carvalho, Nuno C Santos
Erythrocyte aggregation is an indicator of cardiovascular risk, which is influenced by plasma fibrinogen concentration. Fibrinogen levels are elevated during cardiovascular diseases. Our main goals were to understand how fibrinogen-erythrocyte binding influences erythrocyte aggregation and how it constitutes a cardiovascular risk factor in essential arterial hypertension (EAH) and chronic heart failure (CHF). Fibrinogen-erythrocyte and erythrocyte-erythrocyte adhesion measurements were conducted by atomic force microscopy (AFM)-based force spectroscopy...
2018: Annals of Medicine
https://www.readbyqxmd.com/read/29676025/an-unsupervised-automatic-segmentation-algorithm-for-breast-tissue-classification-of-dedicated-breast-computed-tomography-images
#20
Marco Caballo, John M Boone, Ritse Mann, Ioannis Sechopoulos
PURPOSE: To develop and evaluate a new automatic classification algorithm able to identify voxels containing skin, vasculature, adipose and fibroglandular tissue in dedicated breast CT images. METHODS: The proposed algorithm combines intensity and region-based segmentation methods with energy minimizing splines and unsupervised data mining approaches for classifying and segmenting the different tissue types. Breast skin segmentation is achieved by a region growing method which uses constraints from the previously extracted skin centerline to add robustness to the model and to reduce the false positive rate...
April 19, 2018: Medical Physics
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