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juvenile polyarteritis nodosa

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https://www.readbyqxmd.com/read/26050653/pharmacology-and-clinical-effect-of-platonin-a-cyanine-photosensitizing-dye-potential-molecular-targets
#1
Jie-Jen Lee, Chia-Fu Chang, Joen-Rong Sheu, Thanasekaran Jayakumar
Platonin, a photosensitizing dye, is known to possess antioxidant and anti-inflammatory activity. Platonin has been used to treat trauma, ulcers and some acute inflammations and it also reported to improve blood circulation and reduce mortality in endotoxin-induced rat models. Our previous studies established that platonin suppresses the lipopolysaccharides (LPS)-induced inflammatory cytokines, including interleukin-1β (IL-1β-+), IL-6, tumor necrosis factor-α (TNF-α), and inducible nitric oxide synthase (iNOS)...
2014: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/26028675/hemorrhage-in-the-central-canal-of-the-cervical-spinal-cord-in-a-coonhound-diagnosed-with-canine-juvenile-polyarteritis-steroid-responsive-meningitis-arteritis
#2
Kelly L Hughes, Susanne M Stieger-Vanegas, Beth A Valentine
Patchy meningeal and parenchymal contrast enhancement of the spinal cord with multifocal central canal dilations was noted in a computed tomography myelogram of the cervical spine of a 6-month-old intact female coonhound with a confirmed diagnosis of canine juvenile polyarteritis and associated hemorrhage within the central canal.
June 2015: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/24730628/juvenile-polyarteritis-nodosa-associated-with-toxoplasmosis-presenting-as-kawasaki-disease
#3
Özge Başaran, Nilgün Çakar, Gökçe Gür, Abdullah Kocabaş, Belgin Gülhan, Fatma Şemsa Çaycı, Banu Acar Çelikel
Polyarteritis nodosa (PAN) is a vasculitis characterized by inflammatory necrosis of medium-sized arteries. Juvenile PAN and Kawasaki disease (KD) both cause vasculitis of the medium-sized arteries, and share common features. They have overlapping clinical features. Treatment should be managed according to the severity of symptoms and persistence of clinical manifestations. Herein is described the case of a 14-year-old boy first diagnosed with KD, who then fulfilled the criteria for juvenile PAN due to the development of severe myalgia, persistent fever, polyneuropathy and coronary arterial dilatation...
April 2014: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/24252000/successful-treatment-of-group-a-%C3%AE-hemolytic-streptococcus-infection-associated-juvenile-cutaneous-polyarteritis-nodosa-with-tonsillectomy
#4
Takeshi Yamamoto, Yuzaburo Inoue, Minako Tomiita, Makiko Oikawa, Naotomo Kambe, Takayasu Arima, Naoki Shimojo, Yoichi Kohno
Cutaneous polyarteritis nodosa (cutaneous PAN) is a form of necrotizing vasculitis of small- and medium-sized arteries, primarily involving the skin. In juvenile cases, cutaneous PAN is known to be frequently associated with Group A β-hemolytic Streptococcus (GAS) infections. We herein describe the first reported juvenile case of GAS-associated recurrent cutaneous PAN successfully improved with tonsillectomy. To avoid the use of steroids and immunosuppressive drugs, especially in juvenile cases, tonsillectomy is a possible treatment for GAS-associated recurrent cutaneous PAN...
2015: Modern Rheumatology
https://www.readbyqxmd.com/read/23580696/catastrophic-intracranial-hemorrhage-as-a-presenting-feature-of-juvenile-polyarteritis-nodosa
#5
Rangan Srinivasaraghavan, Sriram Krishnamurthy, Subramanian Mahadevan
Intracranial hemorrhage has been rarely reported during the course of polyarteritis nodosa. We describe a 6-year-old boy who presented with fever, altered sensorium, skin rash, hypertension, and catastrophic intracranial hemorrhage. After surgical evacuation of the intracranial hematoma, he underwent a computerized tomography angiogram that showed narrowing of the right anterior cerebral artery. Skin biopsy showed small vessel vasculitis. Nerve conduction studies were suggestive of mononeuritis multiplex. He was diagnosed as polyarteritis nodosa and managed with immunosuppressants, to which he responded favorably...
June 2014: Journal of Child Neurology
https://www.readbyqxmd.com/read/23104659/haemophagocytic-syndrome-in-rheumatic-patients-a-systematic-review
#6
REVIEW
M Atteritano, A David, G Bagnato, C Beninati, A Frisina, C Iaria, G Bagnato, A Cascio
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH), is a potentially fatal hyperinflammatory syndrome characterized fever, hepatosplenomegaly, and cytopenias. HLH can be either primary, with a genetic aetiology, or secondary, associated with malignancies, autoimmune diseases, or infections. Among rheumatic disorders, HLH occurs most frequently in systemic juvenile idiopathic arthritis. AIM: To draw attention on this severe syndrome that may often go undiagnosed in patient with rheumatic diseases...
October 2012: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/22845169/a-review-of-pediatric-vasculitis-with-a-focus-on-juvenile-polyarteritis-nodosa
#7
REVIEW
Tamihiro Kawakami
Systemic polyarteritis nodosa (PAN) is a vasculitis characterized and defined by necrotizing inflammatory changes in medium and/or small arteries. Children and adults with vasculitis differ in the relative frequency of some clinical manifestations and concomitant diseases. The European League against Rheumatism (EULAR)/Pediatric Rheumatology European Society (PRES) working group has proposed a classification of childhood vasculitis. With support from EULAR, the Pediatric Rheumatology International Trials Organization (PRINTO), and PRES, a formal statistical validation process, which included large-scale, web-based data collection, was undertaken...
December 1, 2012: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/22361667/atmospheric-pollution-influence-on-hospital-admissions-in-paediatric-rheumatic-diseases
#8
J P Vidotto, L A A Pereira, A L F Braga, C A Silva, A M Sallum, L M Campos, L C Martins, S C L Farhat
OBJECTIVE: To investigate the lag structure effects from exposure to atmospheric pollution in acute outbursts in hospital admissions of paediatric rheumatic diseases (PRDs). METHODS: Morbidity data were obtained from the Brazilian Hospital Information System in seven consecutive years, including admissions due to seven PRDs (juvenile idiopathic arthritis, systemic lupus erythematosus, dermatomyositis, Henoch-Schönlein purpura, polyarteritis nodosa, systemic sclerosis and ankylosing spondylitis)...
April 2012: Lupus
https://www.readbyqxmd.com/read/22222048/giant-coronary-artery-aneurysms-in-juvenile-polyarteritis-nodosa-a-case-report
#9
Therese L Canares, Dawn M Wahezi, Kanwal M Farooqi, Robert H Pass, Norman T Ilowite
Juvenile polyarteritis nodosa (PAN) is a rare, necrotizing vasculitis, primarily affecting small to medium-sized muscular arteries. Cardiac involvement amongst patients with PAN is uncommon and reports of coronary artery aneurysms in juvenile PAN are exceedingly rare. We describe a 16 year old girl who presented with fever, arthritis and two giant coronary artery aneurysms, initially diagnosed as atypical Kawasaki disease and treated with IVIG and methylprednisolone. Her persistent fevers, arthritis, myalgias were refractory to treatment, and onset of a vasculitic rash suggested an alternative diagnosis...
2012: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/20732942/cranial-nerve-involvement-with-juvenile-polyarteritis-nodosa-clinical-manifestations-and-treatment
#10
Dawn M Wahezi, William A Gomes, Norman T Ilowite
Juvenile polyarteritis nodosa, a rare systemic vasculitis, may present with a wide variety of clinical manifestations. Neurologic involvement has been reported in as high as 50% to 70% of patients; however, the incidence of cranial nerve palsies is extremely uncommon. We report here the case of a 20-month-old girl with juvenile polyarteritis nodosa who developed cranial nerve III palsy, demonstrated both clinically and radiographically on MRI despite aggressive management with immunosuppressants. Neurologic manifestations resolved with treatment including corticosteroids and cyclophosphamide; however, persistent fevers, rash, and headaches interfered with attempts at a corticosteroid taper...
September 2010: Pediatrics
https://www.readbyqxmd.com/read/19796529/mutations-polymorphisms-in-a-monogenetic-autoinflammatory-disease-may-be-susceptibility-markers-for-certain-rheumatic-diseases-lessons-from-the-bedside-for-the-benchside
#11
S Ozen
Certain vasculitides have an increased prevalence among patients with familial Mediterranean fever (FMF). Subsequently, it was noticed that patients with certain rheumatic diseases had an increased carrier rate for mutations in the MEFV gene including seronegative spondyloarhtropatheis, Henoch Schönlein purpura, polyarteritis nodosa and some forms of juvenile idiopathic arthritis. Furthermore in populations where the disease is rare, certain polymorphisms have been associated with a severe inflammatory complication in arthritis...
March 2009: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/18548981/anti-tumor-necrosis-factor-therapy-6-year-experience-of-a-single-center-in-northern-israel-and-possible-impact-of-health-policy-on-results
#12
Yolanda Braun-Moscovici, Doron Markovits, Alexander Rozin, Kochava Toledano, A Menahem Nahir, Alexandra Balbir-Gurman
BACKGROUND: Infliximab and etanercept have been included in the Israeli national list of health services since 2002 for rheumatoid arthritis and juvenile idiopathic arthritis, and since 2005 for psoriatic arthritis and ankylosing spondylitis. The regulator (Ministry of Health and health funds) mandates using fixed doses of infliximab as the first drug of choice and prohibits increased dosage. For other indications (e.g., vasculitis), anti-tumor necrosis factor therapy is given on a "compassionate" basis in severe refractory disease...
April 2008: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/18538831/vasculitis-of-the-temporal-arteries-in-the-young
#13
REVIEW
Gideon Nesher, Shirly Oren, Graciela Lijovetzky, Ronit Nesher
OBJECTIVE: Temporal artery vasculitis (TAV) in patients younger than 50 years is extremely rare. A case of TAV in an 18-year-old man is described here, followed by a literature review regarding cases of all types of vasculitic involvement of the temporal arteries in the young. METHODS: Review of the English literature on vasculitis involving the temporal arteries in young patients, based on a PubMed search. RESULTS: Less than 40 cases of vasculitic involvement of temporal arteries in the young have been described...
October 2009: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/18537653/central-nervous-system-involvement-in-pediatric-rheumatic-diseases-current-concepts-in-treatment
#14
REVIEW
Ali Duzova, Aysin Bakkaloglu
Central nervous system (CNS) manifestations are not rare in pediatric rheumatic diseases. They may be a relatively common feature of the disease, as in systemic lupus erythematosus (SLE) and Behçet's disease. Direct CNS involvement of a systemic rheumatic disease, primary CNS vasculitis, indirect involvement secondary to hypertension, hypoxia and metabolic changes, and drug associated adverse events may all result in CNS involvement. We have reviewed the CNS manifestations of SLE, Behçet's disease, Henoch-Schönlein purpura, polyarteritis nodosa, juvenile idiopathic arthritis, juvenile ankylosing spondylitis, familial Mediterranean fever, scleroderma, sarcoidosis, Wegener's granulomatosis, Takayasu's arteritis, CINCA syndrome, Kawasaki disease, and primary CNS vasculitis; and adverse CNS effects of anti-rheumatic drugs in pediatric patients...
2008: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/17219021/tumor-necrosis-factor-blockade-in-the-management-of-children-with-orphan-diseases
#15
Riva Brik, Vardit Gepstein, Eli Shahar, Dorit Goldsher, Drora Berkovitz
Tumor necrosis factor (TNF) blockade has been used successfully to treat a number of rheumatic disorders that have a substantial burden of illness. In children, the TNF antagonists are used mainly for the treatment of juvenile idiopathic arthritis (JIA). There are, however, a variety of rare systemic inflammatory diseases, in which TNF blockade appears promising. Preliminary data in adults suggest that several forms of vasculitis appear to be responsive to TNF antagonists-Behcet's disease, polyarteritis nodosa, Wegener granulomatosis, among others...
October 2007: Clinical Rheumatology
https://www.readbyqxmd.com/read/17058387/-juvenile-cutaneous-polyarteritis-nodosa-associated-with-streptococcal-infection
#16
F Ramos, R Figueira, J E Fonseca, H Canhão, A Mouzinho, P Valente, J T Costa, M Viana Queiroz
Polyarteritis nodosa is a rare vasculitis of small and medium arteries. It can occur in a systemic form with multi-organ involvement, or as a limited form confined to the skin, muscles, joints and peripheral nerves called cutaneous polyarteritis nodosa. Both forms are rare in adults and even more in children. The caues of this vasculitis remain unknown but some viruses and bacteria have been implicated, specially, Streptococcus. We present the case of a 6-year-old child who developed cutaneous polyarteritis nodosa following a probable streptococcal infection...
January 2006: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/16765711/catastrophic-kawasaki-disease-or-juvenile-polyarteritis-nodosa
#17
REVIEW
Marco A Yamazaki-Nakashimada, Margarita Espinosa-Lopez, Victor Hernandez-Bautista, Sara Espinosa-Padilla, Francisco Espinosa-Rosales
OBJECTIVE: Juvenile Polyarteritis nodosa (PAN) and Kawasaki Disease (KD) are disseminated vasculitides of unknown cause affecting small- and medium-sized vessels in children. We present an unusually severe case that fulfilled criteria for both KD and PAN. The diagnosis, overlapping clinical features, and treatment options for the 2 diseases are discussed. METHODS: A 3-year-old girl with systemic vasculitis is presented. We compare our case to 4 other cases reported in the literature which presented with a similar diagnostic dilemma...
June 2006: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/15480378/juvenile-polyarteritis-results-of-a-multicenter-survey-of-110-children
#18
MULTICENTER STUDY
Seza Ozen, Jordi Anton, Nil Arisoy, Aysin Bakkaloglu, Nesrin Besbas, Paul Brogan, Julia García-Consuegra, Pavla Dolezalova, Frank Dressler, Ali Duzova, Virgínia Paes Leme Ferriani, Maria Odete Esteves Hilário, Mercedes Ibáñez-Rubio, Ozgur Kasapcopur, Wietse Kuis, Thomas J A Lehman, Dana Nemcova, Susan Nielsen, Sheila Knupp Oliveira, Kenneth Schikler, Flavio Sztajnbok, Maria Teresa Terreri, Francesco Zulian, Patricia Woo
OBJECTIVE: To characterize pediatric patients who had been diagnosed with polyarteritis nodosa (PAN) through necrotizing vasculitis of the small and mid-size arteries or those with characteristic findings on angiograms data were collected. STUDY DESIGN: Pediatricians were asked to classify their patients into one of the four suggested groups for juvenile PAN. Twenty-one pediatric centers worldwide participated with 110 patients. RESULTS: The girl:boy ratio was 56:54, with a mean age of 9...
October 2004: Journal of Pediatrics
https://www.readbyqxmd.com/read/14994998/vascular-and-connective-tissue-diseases-in-the-paediatric-world
#19
REVIEW
F Falcini
Despite the fact that in recent decades many advances have been made in classification, outcomes measurements and therapeutic regimens, connective tissue diseases remain a challenge for paediatric rheumatologists. Corticosteroids are still the first choice therapy in juvenile systemic lupus erythematosus (SLE); however, it is time for a new therapeutic approach with immunosuppressant drugs in order to obtain a more prolonged survival and reduced organ system damage. A prevention of relapse of thromboembolic phenomena using low-dose aspirin is strongly suggested in children with anticardiolipin antibodies, particularly in those with SLE...
2004: Lupus
https://www.readbyqxmd.com/read/14108910/collagen-disease-in-children-differential-diagnosis
#20
E J BREWER
No abstract text is available yet for this article.
January 1963: Texas Medicine
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