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juvenile temporal arteritis

Corrado Campochiaro, Barbara Guglielmi, Alvise Berti, Giulio Cavalli, Simonetta Gerevini, Claudio Doglioni, Maria Grazia Sabbadini, Lorenzo Dagna
Juvenile temporal arteritis is a rare inflammatory disease of the temporal arteries that affects young adults. The clinical course is benign and the surgical excision of the affected artery is usually curative. Here we report a case of bilateral juvenile temporal arteritis with significant peripheral eosinophilia and elevated IgE, refractory to surgical excision and even to a short course of corticosteroids. Methotrexate, added as a steroid-sparing agent, resulted in a good disease control.
2016: Modern Rheumatology
Tayfun Akalin, Fatma C Kaya, Yucel Tekin
Temporal arteritis in the young is clinically and histologically different from classic giant cell arteritis of the elderly population. A male patient, aged 36 years, presented with headache and a nodule in his left temporal region. Histological examination of the nodule showed that the left temporal artery was encircled by a lymphoid tissue with prominent germinal centres. The arterial wall was infiltrated with mixed inflammatory cells, the internal elastic lamina was disrupted, and there was marked intimal hyperplasia...
May 2014: Clinical and Experimental Rheumatology
Lucy McGeoch, Walter B Silecky, John Maher, Simon Carette, Christian Pagnoux
Temporal arteritis in the form of giant cell arteritis (GCA) is common in the elderly but is extremely rare in patients less than 50 years of age. We describe two male patients: one who presented at the age of 31 years with painful, nodular swellings of both temporal arteries and whose temporal artery biopsy demonstrated a non-giant cell panarteritis with mixed inflammatory cell infiltrate typical of juvenile temporal arteritis (JTA); another one, aged 40 years, who presented with headache and cerebral angiography consistent with an intracranial vasculitis and whose temporal artery biopsy confirmed an authentic multinucleated GCA...
May 2013: Joint, Bone, Spine: Revue du Rhumatisme
M Atteritano, A David, G Bagnato, C Beninati, A Frisina, C Iaria, G Bagnato, A Cascio
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH), is a potentially fatal hyperinflammatory syndrome characterized fever, hepatosplenomegaly, and cytopenias. HLH can be either primary, with a genetic aetiology, or secondary, associated with malignancies, autoimmune diseases, or infections. Among rheumatic disorders, HLH occurs most frequently in systemic juvenile idiopathic arthritis. AIM: To draw attention on this severe syndrome that may often go undiagnosed in patient with rheumatic diseases...
October 2012: European Review for Medical and Pharmacological Sciences
Cándido Díaz-Lagares, Rafael Belenguer, Manuel Ramos-Casals
OBJECTIVE: To analyze published evidence about adalimumab use in autoimmune diseases. METHODS: Systematic review of MEDLINE database of citations included from January 1990 to December 2008 employing the terms "adalimumab" and the different systemic autoimmune diseases. RESULTS: Our search identified 241 potentially relevant citations. 154 were retrieved for detailed evaluation. Finally, 18 were selected as relevant, including 54 patients...
May 2010: Reumatología Clinica
Necati Cakır, Ömer Nuri Pamuk, Emine Derviş, Neşe Imeryüz, Haşim Uslu, Ömer Benian, Edip Elelçi, Genco Erdem, Fatma Oğuz Sarvan, Mustafa Senocak
To study the prevalence major rheumatic diseases in western Turkey. This survey was conducted in Havsa which have a total population of 18,771. Physicians and interns visited every household, interviewed face to face a questionnaire about the symptoms of rheumatic disorders. The individuals replied positively to any question were examined at the nearest health center. Those have no objective findings related to any rheumatic diseases were excluded. People could not be clinically diagnosed were asked to come to the hospital for further evaluation...
April 2012: Rheumatology International
Cecile Durant, Jérome Connault, Julie Graveleau, Claire Toquet, Jean M Brisseau, Mohamed Hamidou
BACKGROUND: Classic giant cell arteritis affects older adults who are aged >50 years. Temporal arteritis is uncommon in young adults but juvenile temporal vasculitis (JTV) is the most frequent form found in young people. Clinical presentation is usually poor, with localized temporal inflammatory changes without consistent systemic manifestations. Generally, the patients have a benign clinical course, without ophthalmic or ischemic manifestations. In these rare JTVs, excision of the involved section of temporal artery is often curative and corticosteroid therapy is not required...
April 2011: Annals of Vascular Surgery
Moon-Bum Kim, Dong-Hoon Shin, Sang-Hee Seo
No abstract text is available yet for this article.
January 2011: International Journal of Dermatology
Olga K Kolman, Henry M Spinelli, Cynthia M Magro
Juvenile temporal arteritis (JTA) is a nongranulomatous inflammation of the temporal artery with fragmentation of the internal elastic lamina and no concurrent systemic manifestations. It is a rare clinicopathologic entity with fewer than 20 reported cases, most of which represent localized disease with no recurrence or systemic symptoms at follow-up of up to 2 years. Histopathologic features can include lymphoeosinophilic infiltrate and endothelial proliferation. As the histology may resemble angiolymphoid hyperplasia with eosinophilia or Kimura disease, whether JTA is a discrete localized disease or a manifestation of these systemic conditions has been debated...
February 2010: Journal of the American Academy of Dermatology
R Querubin, M Abubaker, B Koplan, C A Agudelo
We present the case of a 69-year-old man with fever of unknown origin, headache, elevated sedimentation rate and peripheral eosinophilia. A biopsy of the temporal artery revealed transmural inflammation with eosinophilia. Therapy with corticosteroids resulted in resolution of the fever, headache, and eosinophilia, as well as normalization of the sedimentation rate. There have been only rare cases of eosinophilia associated with temporal arteritis. All of these cases were seen in patients with either juvenile temporal arteritis, acquired immunodeficiency syndrome, or Buerger's disease...
February 2000: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
K Ito, H Hara, T Okada, T Terui
Hypereosinophilic syndrome (HES) is a multisystem disease with a high mortality rate. It is characterized by peripheral blood eosinophilia and eosinophilic infiltration of the skin and many other organs. The commonest cutaneous features include erythematous pruritic maculopapules and nodules, angio-oedema or urticarial plaques. However, some case reports have indicated that eosinophilic cellulitis, cutaneous necrotizing eosinophilic vasculitis, Raynaud's phenomenon and digital gangrene may also occur as cutaneous features of HES...
July 2009: Clinical and Experimental Dermatology
Yolanda Braun-Moscovici, Doron Markovits, Alexander Rozin, Kochava Toledano, A Menahem Nahir, Alexandra Balbir-Gurman
BACKGROUND: Infliximab and etanercept have been included in the Israeli national list of health services since 2002 for rheumatoid arthritis and juvenile idiopathic arthritis, and since 2005 for psoriatic arthritis and ankylosing spondylitis. The regulator (Ministry of Health and health funds) mandates using fixed doses of infliximab as the first drug of choice and prohibits increased dosage. For other indications (e.g., vasculitis), anti-tumor necrosis factor therapy is given on a "compassionate" basis in severe refractory disease...
April 2008: Israel Medical Association Journal: IMAJ
Gideon Nesher, Shirly Oren, Graciela Lijovetzky, Ronit Nesher
OBJECTIVE: Temporal artery vasculitis (TAV) in patients younger than 50 years is extremely rare. A case of TAV in an 18-year-old man is described here, followed by a literature review regarding cases of all types of vasculitic involvement of the temporal arteries in the young. METHODS: Review of the English literature on vasculitis involving the temporal arteries in young patients, based on a PubMed search. RESULTS: Less than 40 cases of vasculitic involvement of temporal arteries in the young have been described...
October 2009: Seminars in Arthritis and Rheumatism
Wafa Koubaa, Michel Verdier, Michael Perez, Janine Wechsler
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare skin disorder of unknown etiology. This paper describes the case of a 34-year-old man with a lesion located on the right part of his forehead. Microscopically, it displayed a typical morphology of ALHE. However, it was exceptional by its intra-arterial location and its prominent lymphocytic rim-like component. Differential diagnoses, with special emphasis to organized thrombosis and juvenile arteritis, are discussed here.
May 2008: Journal of Cutaneous Pathology
Burke A Cunha, Naveed Hamid, Vitaly Krol, Lawrence Eisenstein
Fever of unknown origin (FUO) is a common clinical diagnostic dilemma. In the elderly, causes of FUO most commonly include malignancy or infection, and less commonly include collagen vascular diseases. Among the collagen vascular diseases causing FUO in the elderly, polymyalgia rheumatica/temporal arteritis, and adult Still's disease (adult juvenile rheumatoid arthritis) are difficult diagnoses to prove. Among the infectious causes of FUO in the elderly are subacute bacterial endocarditis, intra-abdominal abscesses, and extrapulmonary tuberculosis...
July 2006: Heart & Lung: the Journal of Critical Care
Iraklis I Pipinos, Russell Hopp, William D Edwards, Stanley J Radio
Temporal arteritis, particularly in its classic form, is exceedingly rare in individuals <50 years old. We report the youngest case of biopsy-proven giant cell temporal arteritis. A 17-year-old male presented with a progressively expanding and pulsatile but otherwise asymptomatic mass in his forehead. The patient's medical history was significant for uveitis since the age of 3, and severe allergic rhinitis, mild asthma, and juvenile rheumatoid arthritis as a young adolescent. Admission laboratory values included a mildly elevated erythrocyte sedimentation rate and C-reactive protein level...
May 2006: Journal of Vascular Surgery
Burke A Cunha, Suhba Parchuri, Sowjania Mohan
BACKGROUND: Fever of unknown origin (FUO) at the present time is most frequently caused by neoplasm and less commonly by infection. Currently, collagen vascular diseases (CVDs) are an uncommon cause of FUO because most are readily diagnosable by serologic methods and do not remain undiagnosed for sufficient time to present as FUOs. CVDs presenting as FUOs not readily diagnosable with specific tests include late-onset rheumatoid arthritis, adult juvenile rheumatoid arthritis, and polymyalgia rheumatica/temporal arteritis (TA)...
March 2006: Heart & Lung: the Journal of Critical Care
Masaharu Fukunaga
A case of juvenile temporal arteritis, which is a rare vascular lesion in children and young adults, associated with Kimura's disease in a healthy 23-year-old asymptomatic man is described. The patient presented with a painless 2.5 cm nodule with eosinophilia and normal erythrocyte sedimentation rate. Histologically, the left superficial artery showed marked intimal thickening with moderate eosinophilic infiltrates, constriction of the vascular lumen, focal disruptions of the internal elastic lamina and media, moderate eosinophilic infiltrates in the adventia, and absence of giant cells...
May 2005: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Chiharu Watanabe, Michiyuki Koga, Yoshihide Honda, Tsunao Oh-I
An asymptomatic nodule appeared in the right temporal region of an 81-year-old woman. Histopathologic examination confirmed significant thickening of the vascular wall, constriction of the vessel lumen, and infiltration of numerous eosinophils and lymphocytes. Giant cells were not seen. Lymphoid follicles and capillaries surrounded the large vessel. Elastica van Gieson staining revealed a laceration of the internal elastic lamina. Based on these clinical and histologic findings, the patient was diagnosed as having juvenile temporal arteritis (JTA), a disease first proposed by Lie and his colleagues in 1975...
February 2002: American Journal of Dermatopathology
N A Afshari, M A Afshari, C S Foster
Ocular inflammation occurs in many patients with systemic rheumatic disease. The best examples are rheumatoid arthritis, juvenile rheumatoid arthritis, temporal arteritis, systemic lupus erythematosus, Wegener's granulomatosis, polyarteritis nodosa, relapsing polychondritis, and Adamantiades-Behçet's disease. Ocular inflammation may precede the symptoms of the systemic disease and can be helpful in systemic diagnosis. After diagnosis, ocular inflammation can mark the severity of the systemic condition. Thus, prompt diagnosis and treatment of inflammatory conditions of the eye are warranted and may be sight- and life-saving...
October 2001: Current Rheumatology Reports
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