keyword
https://read.qxmd.com/read/38294114/systematic-review-of-tularemia-during-pregnancy
#21
JOURNAL ARTICLE
Shannon Fleck-Derderian, K Meryl Davis, Jessica Winberg, Christina A Nelson, Dana Meaney-Delman
BACKGROUND: Tularemia is caused by the gram-negative bacterium Francisella tularensis. Although rare, tularemia during pregnancy has been associated with pregnancy complications; data on efficacy of recommended antimicrobials for treatment are limited. We performed a systematic literature review to characterize clinical manifestations of tularemia during pregnancy and examine maternal, fetal, and neonatal outcomes with and without antimicrobial treatment. METHODS: We searched 9 databases, including Medline, Embase, Global Health, and PubMed Central, using terms related to tularemia and pregnancy...
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38294113/tularemia-from-veterinary-occupational-exposure
#22
JOURNAL ARTICLE
Grace E Marx, Emily Curren, Marisa Olesen, Laura Cronquist, Levi Schlosser, Matthew Nichols, Maria Bye, Andrea Cote, David W McCormick, Christina A Nelson
Tularemia is a disease caused by Francisella tularensis, a highly infectious bacteria that can be transmitted to humans by direct contact with infected animals. Because of the potential for zoonotic transmission of F. tularensis, veterinary occupational risk is a concern. Here, we report on a human case of tularemia in a veterinarian after an accidental needlestick injury during abscess drainage in a sick dog. The veterinarian developed ulceroglandular tularemia requiring hospitalization but fully recovered after abscess drainage and a course of effective antibiotics...
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38294112/confirmed-case-of-longstanding-respiratory-francisella-tularensis-holarctica-infection-nebraska-2022
#23
JOURNAL ARTICLE
Rachael Birn, Jeff Hamik, Lana Dayne, Justin Frederick, Amanda Bartling, Peter C Iwen, Adam Wells, Matthew Donahue
A male patient with distant history of extensive rabbit contact and pulmonary nodules for 6 years developed empyema. Francisella tularensis holarctica was isolated from thoracentesis fluid. Retrospective immunohistochemical examination of a pulmonary nodule, biopsied 3 years prior, was immunoreactive for F. tularensis. These findings suggest the potential for chronic tularemia.
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38294111/efficacy-of-doxycycline-and-ciprofloxacin-for-treatment-of-pneumonic-tularemia-in-cynomolgus-macaques
#24
JOURNAL ARTICLE
Mark S Williams
BACKGROUND: The incidence of pneumonic tularemia is very low; therefore, it is not feasible to conduct clinical efficacy testing of tularemia medical countermeasures (MCMs) in humans. The US Food and Drug Administration's Animal Model Qualification Program under the Drug Development Tools Program is a regulatory pathway for animal models used in MCM efficacy testing and approval under the Animal Rule. The National Institute of Allergy and Infectious Diseases and Biomedical Advanced Research and Development Authority worked together to qualify the cynomolgus macaque model of pneumonic tularemia...
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38294110/francisella-tularensis-bone-and-joint-infections-united-states-2004-2023
#25
JOURNAL ARTICLE
Amy M Beeson, Molly Baker, BreeAnna Dell, Hannah Schnitzler, Hanna N Oltean, Tracy Woodall, Francis Riedo, Amy Schwartz, Jeannine Petersen, Alison F Hinckley, Grace E Marx
Tularemia is caused by the highly infectious bacterium Francisella tularensis, which is recognized as a Tier 1 bioterrorism agent. Tularemia has a range of recognized clinical manifestations, but fewer than 20 bone or joint infections from 6 countries have been reported in the literature to date. This series includes 13 cases of F. tularensis septic arthritis or osteomyelitis in the United States during 2004-2023 and describes exposures, clinical presentation, diagnosis, and outcomes for this rare but severe form of tularemia...
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38294109/tularemia-a-storied-history-an-ongoing-threat
#26
JOURNAL ARTICLE
Christina A Nelson, Anders Sjöstedt
No abstract text is available yet for this article.
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38294108/systematic-review-clinical-features-antimicrobial-treatment-and-outcomes-of-human-tularemia-1993-2023
#27
JOURNAL ARTICLE
Christina A Nelson, Jessica Winberg, Taylor D Bostic, K Meryl Davis, Shannon Fleck-Derderian
BACKGROUND: Francisella tularensis, the causative agent of tularemia, is endemic throughout the Northern Hemisphere and requires as few as 10 organisms to cause disease, making this potential bioterrorism agent one of the most infectious bacterial pathogens known. Aminoglycosides, tetracyclines, and, more recently, fluoroquinolones are used for treatment of tularemia; however, data on the relative effectiveness of these and other antimicrobial classes are limited. METHODS: Nine databases, including Medline, Global Health, and Embase, were systematically searched for articles containing terms related to tularemia...
January 31, 2024: Clinical Infectious Diseases
https://read.qxmd.com/read/38247118/rare-case-of-tularemia-with-preauricular-lymphadenopathy-and-conjunctivitis-in-a-27-year-old-male-patient-in-germany
#28
JOURNAL ARTICLE
J Kornmann, C Scherl, A Lammert, N Rotter, L Huber
Tularemia is a rare disease but shows an approximately 10-fold increase in reported cases over the last 15 years in Germany. Clinical symptoms of acute tularemia infection are various, which often delays diagnosis. This case report gives an overview of the clinical manifestations of acute tularemia and shows the importance of interdisciplinary work to shorten the time from the onset of symptoms to effective treatment in infection with Francisella tularensis . Since some cases of tularemia are life-threatening, early diagnosis is vital...
January 21, 2024: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/38206513/successful-treatment-of-glandular-tularemia-with-azithromycin-in-a-pregnant-woman-in-austria
#29
JOURNAL ARTICLE
Lorenz Schubert, Marita Koelz, Manuel Kussmann, Sylvia Metz-Schimmerl, Selma Tobudic, Ludwig Traby, Matthias G Vossen, Stefan Winkler
Treatment of tularemia during pregnancy is challenging due to toxicity of standard treatment regimens. Here, we report a 31-year-old woman with glandular tularemia who was successfully treated with intravenous azithromycin. Follow-up examinations over a 6-month period showed a sustained response to treatment. She later gave birth to a healthy child.
January 11, 2024: Infection
https://read.qxmd.com/read/38192304/first-molecular-detection-of-francisella-tularensis-in-turtle-testudo-graeca-and-ticks-hyalomma-aegyptium-in-northwest-of-iran
#30
JOURNAL ARTICLE
Amir Tukmechi, Abdulghaffar Ownagh, Ahmad Enferadi, Peyman Khademi
Francisella tularensis , causative agent of tularemia, is a contagious zoonotic ailment. This study was aimed to molecularly detect F. tularensis in tortoise blood (n = 100) and ticks (n = 100) collected in the West Azerbaijan province, Iran suing a 16SrRNA gene of the Francisella genus through employment of the Nested-PCR technique. The identified ticks were s Hyalomma aegyptium by morphological analysis. Seven percent (with a 95% CI: 3.5%-13.75%) of animal blood samples yielded positive results for the presence of the Francisella ...
April 2024: International Journal for Parasitology. Parasites and Wildlife
https://read.qxmd.com/read/38156016/bacteriophage-spo1-protein-gp46-suppresses-functions-of-hu-protein-in-francisella-tularensis
#31
JOURNAL ARTICLE
Petra Spidlova, Eliska Sokolova, Pavla Pavlik
The nucleoid-associated protein HU is a common bacterial transcription factor, whose role in pathogenesis and virulence has been described in many bacteria. Our recent studies showed that the HU protein is an indispensable virulence factor in the human pathogenic bacterium Francisella tularensis , a causative agent of tularemia disease, and that this protein can be a key target in tularemia treatment or vaccine development. Here, we show that Francisella HU protein is inhibited by Gp46, a protein of Bacillus subtilis bacteriophage SPO1...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38081209/-tularemia-the-interesting-case
#32
JOURNAL ARTICLE
Birgit Didczuneit-Sandhop, Katharina Böhm, Thomas Kalinski, Manja Jolie
No abstract text is available yet for this article.
December 11, 2023: Laryngo- Rhino- Otologie
https://read.qxmd.com/read/37975637/the-rlvs-%C3%AE-capb-iglabc-vaccine-provides-potent-protection-in-fischer-rats-against-inhalational-tularemia-caused-by-various-virulent-francisella-tularensis-strains
#33
JOURNAL ARTICLE
Kevin D Mlynek, Curtis R Cline, Sergei S Biryukov, Ronald G Toothman, Beth A Bachert, Christopher P Klimko, Jennifer L Shoe, Melissa Hunter, Zander M Hedrick, Jennifer L Dankmeyer, Sherry Mou, David P Fetterer, Ju Qiu, Eric D Lee, Christopher K Cote, Qingmei Jia, Marcus A Horwitz, Joel A Bozue
Francisella tularensis is one of the several biothreat agents for which a licensed vaccine is needed. To ensure vaccine protection is achieved across a range of virulent F. tularensis strains, we assembled and characterized a panel of F. tularensis isolates to be utilized as challenge strains. A promising tularemia vaccine candidate is rLVS Δ capB / iglABC (rLVS), in which the vector is the LVS strain with a deletion in the capB gene and which additionally expresses a fusion protein comprising immunodominant epitopes of proteins IglA, IglB, and IglC...
December 15, 2023: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/37916743/tularemia-a-re-emerging-disease-with-growing-concern
#34
JOURNAL ARTICLE
Rinku Sharma, Rajendra Damu Patil, Birbal Singh, Sandip Chakraborty, Deepak Chandran, Kuldeep Dhama, Devi Gopinath, Gauri Jairath, Ajayta Rialch, Gorakh Mal, Putan Singh, Wanpen Chaicumpa, G Saikumar
Tularemia caused by Gram-negative, coccobacillus bacterium, Francisella tularensis, is a highly infectious zoonotic disease. Human cases have been reported mainly from the United States, Nordic countries like Sweden and Finland, and some European and Asian countries. Naturally, the disease occurs in several vertebrates, particularly lagomorphs. Type A (subspecies tularensis) is more virulent and causes disease mainly in North America; type B (subspecies holarctica) is widespread, while subspecies mediasiatica is present in central Asia...
November 2, 2023: Veterinary Quarterly
https://read.qxmd.com/read/37889940/seroprevalence-blood-chemistry-and-patterns-of-canine-parvovirus-distemper-virus-plague-and-tularemia-in-free-ranging-coyotes-canis-latrans-in-northern-new-mexico-usa
#35
JOURNAL ARTICLE
Leah M White, Suzanne J Gifford, Gail Kaufman, Eric Gese, Mark A Peyton, Robert R Parmenter, James W Cain
Wildlife diseases have implications for ecology, conservation, human health, and health of domestic animals. They may impact wildlife health and population dynamics. Exposure rates of coyotes (Canis latrans) to pathogens such as Yersinia pestis, the cause of plague, may reflect prevalence rates in both rodent prey and human populations. We captured coyotes in north-central New Mexico during 2005-2008 and collected blood samples for serologic surveys. We tested for antibodies against canine distemper virus (CDV, Canine morbillivirus), canine parvovirus (CPV, Carnivore protoparvovirus), plague, tularemia (Francisella tularensis), and for canine heartworm (Dirofilaria immitis) antigen...
October 27, 2023: Journal of Wildlife Diseases
https://read.qxmd.com/read/37877608/three-cases-of-tickborne-francisella-tularensis-infection-austria-2022
#36
JOURNAL ARTICLE
Florian Heger, Stefanie Schindler, Sonja Pleininger, Astrid Fueszl, Marion Blaschitz, Kathrin Lippert, Patrick Hyden, Peter Hufnagl, David Mutschlechner, Thomas Gremmel, Erwin Hofer, Mateusz Markowicz, Alexander Indra
Tularemia is increasing in Austria. We report Francisella tularensis subspecies holarctica isolated from 3 patients who had been bitten by arthropods. Next-generation sequencing showed substantial isolate similarity. Clinicians should consider bloodstream F. tularensis infections for patients with signs/symptoms of ulceroglandular tularemia, and surveillance of potential vectors should be intensified.
November 2023: Emerging Infectious Diseases
https://read.qxmd.com/read/37875923/positive-francisella-tularensis-meningitis-outcome-despite-delayed-identification-a-case-report
#37
JOURNAL ARTICLE
Vesa Mäki-Koivisto, Marianne Korkala, Lotta Simola, Sonja Suutari-Kontio, Sini Koivunen, Teija Puhto, Ilkka S Junttila
Francisella tularensis is a Gram-negative bacteria, that may cause a zoonotic disease, tularemia. Here, we describe a patient case, where a previously healthy young woman in Northern Finland contacted health care because of fever and headache. Due to the symptoms and lack of further diagnostic tools in primary health care, she was transferred to University Hospital (UH) where ampicillin and ceftriaxone was given empirically. A cerebrospinal fluid sample (CSF) was drawn showing small Gram-negative rods that grew on chocolate agar after 2 days of incubation...
October 24, 2023: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/37857320/-carcinoma-tuberculosis-atypical-pneumonia-or-may-be-pulmonary-tularemia-two-case-reports
#38
JOURNAL ARTICLE
Martin Kimmich, Maja Jakob
Tularemia is a rare zoonotic disease, endemic in rural areas all over Germany. It's clinical manifestation following inhalation of infectious aerosols may resemble pulmonary neoplasia, other atypical pneumonias or tuberculosis. Here we describe two representative cases with pulmonary tularemia.
October 19, 2023: Pneumologie
https://read.qxmd.com/read/37812206/-bacterial-infections-of-the-skin-in-the-context-of-climate-change-and-migration
#39
REVIEW
Henning Klapproth, Laurenz Klapproth, Tamara Ruegamer, Florian Uhl, Jonathan Jantsch, Mario Fabri
BACKGROUND: In the context of climate change and migration, both common and previously less common pathogens are gaining importance as cutaneous bacterial infections. OBJECTIVE: To inform medical professionals about challenges to dermatology posed by climate change and migration. MATERIALS AND METHODS: Review of the current literature on emerging antimicrobial resistance and emerging pathogens in general and on the epidemiological situation in Germany in particular...
October 9, 2023: Dermatologie (Heidelb)
https://read.qxmd.com/read/37800934/tolfenpyrad-displays-francisella-targeted-antibiotic-activity-that-requires-an-oxidative-stress-response-regulator-for-sensitivity
#40
JOURNAL ARTICLE
Ashley Clarke, Isabelle M Llabona, Nimra Khalid, Danielle Hulvey, Alexis Irvin, Nicole Adams, Henry S Heine, Aria Eshraghi
Francisella tularensis is a highly infectious Gram-negative bacterial pathogen capable of animal-to-human transmission. Due to its remarkable pathogenicity and potential for widespread public health impact, F. tularensis is classified as a high-priority pathogen by the Centers for Disease Control and Prevention. The historical development of Francisella as a bioweapon, coupled with the ease of engineering antibiotic-resistant strains, has spurred interest in the discovery of novel antibiotics. A library of drug-like compounds was screened for their ability to inhibit the growth of Francisella novicida , a biosafety level-2 surrogate for F...
October 6, 2023: Microbiology Spectrum
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