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Tularemia

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https://www.readbyqxmd.com/read/29311235/deletion-of-the-mfs-transporter-fptb-alters-host-cell-interactions-and-attenuates-the-virulence-of-type-a-francisella-tularensis
#1
Phillip M Balzano, Aimee L Cunningham, Christen Grassel, Eileen M Barry
Francisella tularensis is a Gram negative facultative intracellular coccobacillus that can infect a wide variety of hosts. In humans, F. tularensis causes the zoonosis tularemia following insect bites, ingestion, inhalation, and the handling of infected animals. That a very small inoculum delivered by the aerosol route can cause severe disease, coupled with the possibility of its use as an aerosolized bioweapon, have led to the classification of Francisella tularensis as a Category A select agent and has renewed interest in the formulation of a vaccine...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29284034/development-of-a-novel-francisella-tularensis-live-vaccine-strain-expressing-ovalbumin-provides-insight-into-antigen-specific-cd8-t-cell-responses
#2
David E Place, David R Williamson, Yevgeniy Yuzefpolskiy, Bhuvana Katkere, Surojit Sarkar, Vandana Kalia, Girish S Kirimanjeswara
Progress towards a safe and effective vaccine for the prevention of tularemia has been hindered by a lack of knowledge regarding the correlates of protective adaptive immunity and a lack of tools to generate this knowledge. CD8+ T cells are essential for protective immunity against virulent strains of Francisella tularensis, but to-date, it has not been possible to study these cells in an antigen-specific manner. Here, we report the development of a tool for expression of the model antigen ovalbumin (OVA) in F...
2017: PloS One
https://www.readbyqxmd.com/read/29280085/usefulness-of-a-single-assay-chemiluminescence-test-tularaemia-virclia-igg%C3%A2-%C3%A2-igm-monotest-for-the-diagnosis-of-human-tularemia-comparison-of-five-serological-tests
#3
África Cubero, Carlos Durántez, Ana Almaraz, Luis Fernández-Lago, María P Gutiérrez, María J Castro, Miguel A Bratos, María Simarro, Gabriel A March, Antonio Orduña
The aim of this work was to ascertain the usefulness of a new commercially-available single-assay chemiluminescence test (CHT) for the diagnosis of human tularemia (Tularaemia VIRCLIA IgG + IgM monotest, Vircell, Santa Fe, Granada, Spain). A total of 773 sera from 773 patients including 364 initial sera from patients with diagnosed tularemia, patients with suspected tularemia not confirmed (100), healthy people (152), patients with serology positive to Brucella (97), patients diagnosed with other infectious diseases (30), and patients diagnosed with autoimmune diseases (30) were included...
December 27, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29240272/amino-acid-deprivation-and-central-carbon-metabolism-regulate-the-production-of-outer-membrane-vesicles-and-tubes-by-francisella
#4
Vinaya Sampath, William D McCaig, David G Thanassi
Francisella tularensis is a highly virulent Gram-negative bacterial pathogen that causes the zoonotic disease tularemia. F. novicida, a model tularemia strain, produces spherical outer membrane vesicles (OMV), as well as novel tubular vesicles and extensions of the cell surface. These OMV and tubes (OMV/T) are produced in a regulated manner and contain known virulence factors. Mechanisms by which bacterial vesicles are produced and regulated are not well understood. We performed a genetic screen in F. novicida to decipher the molecular basis for regulated OMV/T formation, and identified both hypo- and hyper-vesiculating mutants...
December 14, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/29239792/francisella-tularensis-and-other-bacteria-in-hares-and-ticks-in-north-rhine-westphalia-germany
#5
Herbert Tomaso, Peter Otto, Martin Peters, Jochen Süss, Axel Karger, Heinz Schamoni, Eric Zuchantke, Helmut Hotzel
Tularemia is a zoonotic disease caused by the bacterium Francisella tularensis. The disease can be transmitted to humans through contact with infected animals such as the European brown hare (Lepus europaeus) and ticks as vectors. The aim of this study was to isolate F. tularensis from ticks and hares in North Rhine-Westphalia using cysteine heart agar to determine their genetic relatedness and to identify other bacteria that grow on this medium. 848 European brown hares and 1556 questing ticks (all Ixodes ricinus) from forests were tested using cultivation and MALDI-TOF mass spectrometry or partial 16S rRNA gene sequencing...
November 21, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29236288/disaster-preparedness-biological-threats-and-treatment-options
#6
Navaneeth Narayanan, Clifton R Lacy, Joseph E Cruz, Meghan Nahass, Jonathan Karp, Joseph A Barone, Evelyn Hermes-DeSantis
Biological disasters can be natural, accidental, or intentional. Biological threats have made a lasting impact on civilization. This review will focus on agents of clinical significance, bioterrorism, and national security; specifically Category A agents (anthrax, botulism, plague, tularemia, and smallpox), as well as briefly discuss other naturally-emerging infections of public health significance including Ebola virus (also a Category A agent) and Zika virus. The role of the pharmacist in disaster preparedness and disaster response is multifaceted and important...
December 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29202201/prevalence-and-seasonality-of-fleas-associated-with-california-ground-squirrels-and-the-potential-risk-of-tularemia-in-an-outdoor-non-human-primate-research-facility
#7
Tara Roth, Rebecca Sammak, Janet Foley
Ectoparasites at primate research centers may be difficult to control, e.g. without exposing non-human primates (NHPs) to toxicants, but their impact on NHP health is poorly understood. In 2010, there was an epizootic of tularemia at the California National Primate Research Center (CNPRC) in Yolo County, California that resulted in 20 confirmed and suspect clinical cases in outdoors housed rhesus macaques (Macaca mulatta [Zimmermann]) and a 53% seroprevalence in the southern section of the colony. We studied ectoparasite burdens at the CNPRC in order to understand possible conditions at the time of the epizootic and provide data for the management of ectoparasites for the future...
November 30, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29171073/evaluation-of-francisella-tularensis-%C3%AE-pdpc-as-a-candidate-live-attenuated-vaccine-against-respiratory-challenge-of-tularemia-in-c57bl-6j-mouse-model
#8
Deyu Tian, Akihiko Uda, Eun-Sil Park, Akitoyo Hotta, Osamu Fujita, Akio Yamada, Kazuhiro Hirayama, Kozue Hotta, Yuuki Koyama, Mika Azaki, Shigeru Morikawa
Francisella tularensis, which causes tularemia, is an intracellular and Gram-negative bacterium. F. tularensis has received significant attention in recent decades because of their history as biological weapons. Thus, the development of novel vaccines directed against tularemia has been an important goal. The attenuated F. tularensis strain δpdpC, in which the pathogenicity determinant protein C gene (pdpC) was disrupted by TargeTron mutagenesis, was investigated as a potential vaccine candidate for tularemia in the present study...
November 24, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29168443/francisella-tularensis-in-muscle-from-diseased-hares-a-risk-factor-for-humans
#9
G Hestvik, H Uhlhorn, T Jinnerot, S Åkerström, F Södersten, D Gavier-Widén
Tularemia caused by the bacterium Francisella tularensis is a zoonotic disease. Tularemia is a common disease in the hare, and as a game species can be an important source of infection for humans. In this study, hares diagnosed with tularemia were examined with the aim to investigate whether the muscle (meat) had any pathological changes and/or contained F. tularensis. Real-time PCR and/or immunohistochemistry (IHC) detected the bacteria in muscle samples from 40 out of 43 investigated hares. IHC showed that bacteria were few and most commonly located in the peri- and endomysium...
November 23, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29168105/evaluation-of-four-commercial-natural-products-for-repellency-and-toxicity-against-the-lone-star-tick-amblyomma-americanum-acari-ixodidae
#10
Erika T Machtinger, Andrew Y Li
Lone star ticks are aggressive ectoparasites of domestic and wild animals, as well as humans. These ticks can transmit many pathogens that cause disease including Erhlichia and tularemia. Common compounds used for personal protection and area sprays are N-diethyl-3-methyl benzamide (DEET) and permethrin, but public concern over personal and environmental safety require the development of new, safer products. In the current study, four commercially available products (Wondercide, Essentria IC(3), Vet's Best, and Mosquito Barrier) were tested for both repellent and toxic effects against lone star tick nymphs and adults...
November 22, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29150245/-skin-manifestations-of-tularemia
#11
E Meriglier, P Roblot, C Landron
No abstract text is available yet for this article.
November 14, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29145508/irruptive-mammal-host-populations-shape-tularemia-epidemiology
#12
Juan J Luque-Larena, François Mougeot, Beatriz Arroyo, Mª Dolors Vidal, Ruth Rodríguez-Pastor, Raquel Escudero, Pedro Anda, Xavier Lambin
No abstract text is available yet for this article.
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29122856/first-draft-genome-sequences-of-three-strains-of-francisella-tularensis-subsp-holarctica-isolated-from-hares-and-a-tick-in-france
#13
Nora Madani, Philippe Giraud, Christiane Mendy, Cécile Colaneri, Emeline Cherchame, Moulay-Ali Cherfa, Céline Richomme, Anouk Decors, Guillaume Girault
Here, we report the complete genome sequences of three strains of Francisella tularensis subsp. holarctica (11-789-5S, 11-935-13S, and 11-930-9S), isolated from brown hares and a tick during a tularemia outbreak in France, where tularemia is endemic.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29118164/evaluation-of-in-house-and-commercial-serological-tests-for-diagnosis-of-human-tularemia
#14
Hadjila Yanes, Aurélie Hennebique, Isabelle Pelloux, Sandrine Boisset, Dominique J Bicout, Yvan Caspar, Max Maurin
Tularemia is a zoonosis caused by the bacterium Francisella tularensis Its specific diagnosis remains based on serological methods, while detection of F. tularensis in clinical samples by culture or PCR is rarely obtained. The aim of the present study was to evaluate the performance of the SERION ELISA classic Francisella tularensis IgG and IgM tests (Virion/Serion GmbH Institute, Würzburg, Germany) and the VIRapid® Tularemia immunochromatographic (ICT) test (VIRCELL, Granada, Spain), compared to the in-house microagglutination (MAT) and indirect immunofluorescence (IFA) tests currently used at the French National Reference Centre for Francisella...
November 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29102170/protection-of-vaccinated-mice-against-pneumonic-tularemia-is-associated-with-an-early-memory-sentinel-response-in-the-lung
#15
Liat Bar-On, Hila Cohen, Uri Elia, Shahar Rotem, Adi Bercovich-Kinori, Erez Bar-Haim, Theodor Chitlaru, Ofer Cohen
Francisella tularensis is the intracellular bacterial pathogen causing the respiratory life-threatening disease tularemia. Development of tularemia vaccines has been hampered by an incomplete understanding of the correlates of immunity. Moreover, the importance of lung cellular immunity in vaccine-mediated protection against tularemia is a controversial matter. Live attenuated vaccine strains of F. tularensis such as LVS (Live Vaccine Strain), elicit an immune response protecting mice against subsequent challenge with the virulent SchuS4 strain, yet the protective immunity against pulmonary challenge is limited in its efficacy and longevity...
October 25, 2017: Vaccine
https://www.readbyqxmd.com/read/29063667/bacterial-lipoproteins-and-other-factors-released-by-francisella-tularensis-modulate-human-neutrophil-lifespan-effects-of-a-tlr1-snp-on-apoptosis-inhibition
#16
Lauren C Kinkead, Laura C Whitmore, Jenna M McCracken, Joshua R Fletcher, Brandi B Ketelsen, Justin W Kaufman, Bradley D Jones, David S Weiss, Jason H Barker, Lee-Ann H Allen
F. tularensis infects several cell types including neutrophils, and aberrant neutrophil accumulation contributes to tissue destruction during tularemia. We demonstrated previously that F. tularensis strains Schu S4 and LVS markedly delay human neutrophil apoptosis and thereby prolong cell lifespan, but the bacterial factors that mediate this aspect of virulence are undefined. Herein, we demonstrate that bacterial conditioned medium (CM) can delay apoptosis in the absence of direct infection. Biochemical analyses show that CM contained F...
October 23, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/29054578/tularemia-in-interepidemic-period
#17
Javier Miguel Martín Guerra, Miguel Martín Asenjo, José María Prieto de Paula
No abstract text is available yet for this article.
October 17, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29029346/botanical-compound-p-anisaldehyde-repels-larval-lone-star-tick-acari-ixodidae-and-halts-reproduction-by-gravid-adults
#18
Allan T Showler, Jessica L Harlien
The lone star tick, Amblyomma americanum (L.), widely distributed across eastern, southeastern, and midwestern regions of the United States and south into Mexico, is an obligate blood feeder that attaches to three hosts during the larval, nymphal, and adult stages. White-tailed deer and wild turkey are common hosts, as well as a wide variety of other avian and mammalian hosts. Amblyomma americanum is the most frequently reported species of tick to bite humans in the southeastern and southcentral United States, and it can transmit diseases that include erhlichiosis, rickettsiosis, tularemia, and protozoan infections...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29018123/characterization-of-inner-and-outer-membrane-proteins-from-francisella-tularensis-strains-lvs-and-schu-s4-and-identification-of-potential-subunit-vaccine-candidates
#19
Deborah M B Post, Bram Slütter, Birgit Schilling, Aroon T Chande, Jed A Rasmussen, Bradley D Jones, Alexandria K D'Souza, Lorri M Reinders, John T Harty, Bradford W Gibson, Michael A Apicella
Francisella tularensis is the causative agent of tularemia and a potential bioterrorism agent. In the present study, we isolated, identified, and quantified the proteins present in the membranes of the virulent type A strain, Schu S4, and the attenuated type B strain, LVS (live vaccine strain). Spectral counting of mass spectrometric data showed enrichment for membrane proteins in both strains. Mice vaccinated with whole LVS membranes encapsulated in poly (lactic-co-glycolic acid) (PLGA) nanoparticles containing the adjuvant polyinosinic-polycytidylic acid [poly(I·C)] showed significant protection against a challenge with LVS compared to the results seen with naive mice or mice vaccinated with either membranes or poly(I·C) alone...
October 10, 2017: MBio
https://www.readbyqxmd.com/read/29017676/rare-cause-of-pleuropnemonia-tularemia-disease
#20
Meltem Agca, Dildar Duman, Ebru Sulu, Fatma Ozbaki, Orcun Barkay, Derya Ozturk, Tulay Yarkin
Tularemia is a zoonotic infection which is caused by gram negative coccobacilli, Francisella tularensis. The disease occurs after contact with blood and body fluids of infected animals, bites and ingestion of infected food and water. Although it commonly presents with skin lesions, there may also be serious organ involvements. A55-year woman was consulted for presumptive diagnosis of tuberculosis. Multiple lymphadenopathy in right cervical area was present on physical examination. Pleural effusion on left side was detected with computed tomography...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
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