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https://www.readbyqxmd.com/read/28938020/seasonal-variations-in-carbon-nitrogen-and-phosphorus-concentrations-and-c-n-p-stoichiometry-in-different-organs-of-a-larix-principis-rupprechtii-mayr-plantation-in-the-qinling-mountains-china
#1
Hailiang Li, M James C Crabbe, Fuli Xu, Weiling Wang, Lihui Ma, Ruilong Niu, Xing Gao, Xingxing Li, Pei Zhang, Xin Ma, Haikui Chen
Understanding how concentrations of elements and their stoichiometry change with plant growth and age is critical for predicting plant community responses to environmental change. We used long-term field experiments to explore how the leaf, stem and root carbon (C), nitrogen (N) and phosphorous (P) concentrations and their stoichiometry changed with growth and stand age in a L. principis-rupprechtii Mayr. plantation from 2012-2015 in the Qinling Mountains, China. Our results showed that the C, N and P concentrations and stoichiometric ratios in different tissues of larch stands were affected by stand age, organ type and sampling month and displayed multiple correlations with increased stand age in different growing seasons...
2017: PloS One
https://www.readbyqxmd.com/read/28928962/current-concepts-and-controversies-in-the-pathogenesis-of-parkinson-s-disease-dementia-and-dementia-with-lewy-bodies
#2
REVIEW
Rimona S Weil, Tammaryn L Lashley, Jose Bras, Anette E Schrag, Jonathan M Schott
Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition. However, until recently, the pathophysiological mechanisms leading to neuronal damage were not known. It was also not understood why some cells are particularly vulnerable in PDD/DLB, nor why some individuals show more aggressive and rapid dementia than others...
2017: F1000Research
https://www.readbyqxmd.com/read/28928300/zoonotic-surveillance-for-rickettsiae-in-rodents-and-mapping-of-vectors-of-rickettsial-diseases-in-india-a-multi-centric-study
#3
Rina Tilak, Rajesh Kunwar, P K Tyagi, Anurag Khera, R K Joshi, Urmila B Wankhade
BACKGROUND: The global resurgence of rickettsial diseases and their potential to impact the fitness of military personnel and inflict widespread casualties amongst civil populations has emerged as a major cause of public health concern. Absence of surveillance system, lack of awareness amongst medical fraternity to rickettsial activity along with the difficulty in diagnosis because of their protean clinical manifestations are reasons for the outbreaks of these diseases. OBJECTIVES: To determine rickettsial activity amongst rodents and study vector diversity, abundance and their distribution to enable mapping of rickettsial hotspots...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28924102/microrna-483-5p-modulates-the-expression-of-cartilage-related-genes-in-human-chondrocytes-through-down-regulating-tgf-%C3%AE-1-expression
#4
Ronghua Xu, Jiayi Li, Bo Wei, Weiling Huo, Liming Wang
Transforming growth factor-β1 (TGF-β1) has been reported to improve chondrocytes phenotype and function. The expression levels of microRNA-483-5p (miR-483-5p), a potential regulator of TGF-β signaling pathway, were elevated in chondrocytes of patients with osteoarthritis. In this study, we aimed to explore the role of miR-483-5p for the expression of cartilage-related genes in chondrocytes. Human chondrocytes were harvested from femoral condyle and tibial plateau of different donors (n = 10) following amputation due to sarcomas not involving the joint space...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28911005/ociad2-suppressed-tumor-growth-and-invasion-via-akt-pathway-in-hepatocelluar-carcinoma
#5
Dan Wu, Xufang Yang, Huiming Peng, Dongmin Guo, Weiling Zhao, Chen Zhao, Xiaobo Zhou
Hepatocellular carcinoma (HCC) is an aggressive tumor and the third leading cause of cancer-related death worldwide. Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) has been found frequently methylated in various cancers, including HCC. The aim of the present study was to investigate the role of OCIAD2 in HCC progression. We analyzed liver hepatocellular carcinoma patients' data from the Cancer Genome Atlas (TCGA), including data extracted from 371 HCC tissues and 50 adjacent normal liver tissues...
September 1, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28903797/prevalence-of-anti-hepatitis-b-surface-antibodies-among-children-and-adolescents-vaccinated-in-infancy-and-effect-of-booster-dose-administered-within-a-pilot-study
#6
R Bassal, M P Markovich, M Weil, E Shinar, Y Carmeli, M Dan, D Sofer, E Mendelson, D Cohen, T Shohat
We determined the prevalence of anti-hepatitis B surface antibodies (anti-HBs) among children and adolescents vaccinated for hepatitis B virus in infancy as part of the routine vaccination programme. A representative serum sample of the Israeli population age 0-19 was tested. In a separate pilot study, a booster dose of hepatitis B vaccine was administered to 31 candidates for national service, who were fully vaccinated in infancy and tested negative for hepatitis B surface antibodies at age 17-19 years and anti-HBs antibodies were assessed 8 weeks later...
September 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28893531/a-systematic-review-of-plantar-plate-repair-in-the-management-of-lesser-metatarsophalangeal-joint-instability
#7
REVIEW
Mohammed Elmajee, Zhiyu Shen, Jamie A'Court, Anand Pillai
The plantar plate is a major structure that maintains metatarsophalangeal joint (MTPJ) stability and has only recently gained attention. Anatomic plantar plate repair can directly address the pathologic entity, rather than relying on indirect reduction of the MTPJ instability by osteotomy or tendon transfer techniques. The present report aimed to determine the effectiveness of plantar plate repair for the treatment of patients with lesser MTPJ instability. Different databases were searched using the guidelines in the Cochrane Handbook and recommendations from the Preferred Reporting Items for Systematic reviews and Meta-Analysis statement...
September 8, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28892473/a-multi-center-field-study-of-two-point-of-care-tests-for-circulating-wuchereria-bancrofti-antigenemia-in-africa
#8
Cédric B Chesnais, Naomi-Pitchouna Awaca-Uvon, Fatoma K Bolay, Michel Boussinesq, Peter U Fischer, Lincoln Gankpala, Aboulaye Meite, François Missamou, Sébastien D Pion, Gary J Weil
BACKGROUND: The Global Programme to Eliminate Lymphatic Filariasis uses point-of-care tests for circulating filarial antigenemia (CFA) to map endemic areas and for monitoring and evaluating the success of mass drug administration (MDA) programs. We compared the performance of the reference BinaxNOW Filariasis card test (ICT, introduced in 1997) with the Alere Filariasis Test Strip (FTS, introduced in 2013) in 5 endemic study sites in Africa. METHODOLOGY: The tests were compared prior to MDA in two study sites (Congo and Côte d'Ivoire) and in three sites that had received MDA (DRC and 2 sites in Liberia)...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28890912/typhoid-and-scrub-typhus-coinfection-in-a-returned-traveler
#9
Christopher Wen-Xing Seow, Veena Logarajah, Natalie Woon Hui Tan
This is a case report of a 12-year-old returned traveler with typhoid and scrub typhus coinfection. The diagnosis of typhoid was made early with blood cultures and Widal Weil Felix serology. Persistent fever despite appropriate antibiotics for typhoid fever prompted a search for concomitant infection, which led to the diagnosis of scrub typhus confirmed by Orientia tsutsugamushi serology. The patient was given doxycycline with good clinical response. Scrub typhus infection should be an early consideration in the differential diagnoses of fever in a returned traveler from regions where it is endemic...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28878522/validation-of-geno-sen-s-scrub-typhus-real-time-polymerase-chain-reaction-kit-by-its-comparison-with-a-serological-elisa-test
#10
Velmurugan Anitharaj, Selvaraj Stephen, Jothimani Pradeep, Pratheesh Pooja, Sridharan Preethi
BACKGROUND: In the recent past, scrub typhus (ST) has been reported from different parts of India, based on Weil-Felix/enzyme-linked immunosorbent assay (ELISA)/indirect immunofluorescence assay (IFA). Molecular tests are applied only by a few researchers. AIMS: Evaluation of a new commercial real time polymerase chain reaction (PCR) kit for molecular diagnosis of ST by comparing it with the commonly used IgM ELISA is our aim. SETTINGS AND DESIGN: ST has been reported all over India including Puducherry and surrounding Tamil Nadu and identified as endemic for ST...
July 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28874477/market-concentration
#11
EDITORIAL
Alan R Weil
No abstract text is available yet for this article.
September 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28873492/-blood-pressure-measurement-and-treatment-targets-position-paper-of-the-dhl%C3%A2-task-force-scientific-statements-and-guidelines
#12
Bernhard K Krämer, Martin Hausberg, Bernd Sanner, Kristina Kusche-Vihrog, Joachim Weil, Burkhard Weisser, Ulrich Wenzel, Peter Trenkwalder
No abstract text is available yet for this article.
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28871463/specific-effects-of-prenatal-dehp-exposure-on-neuroendocrine-gene-expression-in-the-developing-hypothalamus-of-male-rats
#13
Na Gao, Ruixia Hu, Yujing Huang, Long Dao, Caifeng Zhang, Yongzhe Liu, Lina Wu, Xutong Wang, Weiling Yin, Andrea C Gore, Zengrong Sun
Endocrine disrupting chemicals may disrupt developing neuroendocrine systems, especially when the exposure occurs during a critical period. This study aimed to investigate whether prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP), a major component of plasticizers used worldwide, disrupted the development of a network of genes important for neuroendocrine function in male rats. Pregnant rats were treated with corn oil (vehicle control), 2, 10 or 50 mg/kg DEHP by gavage from gestational day 14 to 19. The neuroendocrine gene expressions were quantified using a 48-gene Taqman qPCR array in the whole hypothalamus of neonatal rats (postnatal day 1) and in the anteroventral periventricular nucleus (AVPV), medial preoptic nucleus (MPN) and arcuate nucleus (ARC) of adult rats (postnatal day 70)...
September 4, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28865592/corrigendum-to-case-series-of-17-modified-weil-s-osteotomies-for-freiberg-s-and-k%C3%A3-hler-s-ii-avn-with-aofas-scoring-pre-and-post-operatively-foot-ankle-surg-17-1-2011-19-24
#14
M C Edmondson, K R Sherry, J Afolayan, A R Armitage, A D Skyrme
No abstract text is available yet for this article.
September 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28862366/redirect-killer-t-cells-via-displaying-azido-sugar-for-tethering-ligands
#15
Weiling Wang, Zhiying Zhao, Ziwei Zhang, Chuanling Zhang, Sulong Xiao, Xinshan Ye, Lihe Zhang, Qing Xia, Demin Zhou
The genetic expression of chimeric antigen receptors (CARs) on the surface of T cells enables the redirection of T-cell specificity. To broaden the versatility of T cells as tumor-specific killers, we developed a non-genetic approach by which azide-containing sialic acids were metabolically incorporated to modify cellular sialyl glycans. Given displaying such a chemical moiety on T cells, small molecular ligands such as RGD and folate, as proof-of-concept, instead of supersized antibodies were clicked orthogonally, leading to highly selective, time- and dose-dependent cytotoxicity to integrin αvβ3- and folate receptor-positive cells, respectively...
September 1, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28846879/insufficient-sleep-is-associated-with-impaired-nitric-oxide-mediated-endothelium-dependent-vasodilation
#16
Anthony R Bain, Brian R Weil, Kyle J Diehl, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza
BACKGROUND AND AIMS: Habitual short nightly sleep duration is associated with increased atherosclerotic cardiovascular disease risk and morbidity. Vascular endothelial dysfunction represents an important mechanism that may underlie this heightened cardiovascular risk. Impaired endothelium-dependent vasodilation, particularly NO-mediated vasodilation, contributes to the development and progression of atherosclerotic vascular disease and acute vascular events. We tested the hypothesis that chronic insufficient sleep is associated with impaired NO-mediated endothelium-dependent vasodilation in middle-aged adults...
August 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28832326/bernard-j-weil-m-boiron-m-jacquillat-c-flandrin-g-gemon-m-f-acute-promyelocytic-leukemia-results-of-treatment-by-daunorubicin-blood-1973-41-4-489-496
#17
(no author information available yet)
No abstract text is available yet for this article.
October 6, 2016: Blood
https://www.readbyqxmd.com/read/28827282/a-novel-image-based-high-throughput-screening-assay-discovers-therapeutic-candidates-for-adult-polyglucosan-body-disease
#18
Leonardo J Solemsky, Netaly Khazanov, Hanoch Senderowitz, Peixiang Wang, Berge A Minassian, Igor M Ferreira, Wyatt W Yue, Alexander Lossos, Miguel Weil, Or Kakhlon
Glycogen storage disorders (GSDs) are caused by excessive accumulation of glycogen. Some GSDs (Adult Polyglucosan Body Disease (APBD), Tarui and Lafora diseases) are caused by intracellular accumulation of insoluble inclusions, called polyglucosan bodies (PB), which are chiefly composed of malconstructed glycogen. We developed an APBD patient skin fibroblast cell-based assay for PB identification, where the bodies are identified as amylase-resistant periodic acid-Schiff's (PAS) stained structures, and quantified...
August 21, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28826214/improved-intraoperative-detection-of-ovarian-cancer-by-folate-receptor-alpha-targeted-dual-modality-imaging
#19
Marlène C H Hekman, Otto C Boerman, Desirée L Bos, Leon F A G Massuger, Susan Weil, Luigi Grasso, Katherine A Rybinski, Egbert Oosterwijk, Peter F A Mulders, Mark Rijpkema
Complete resection of tumor lesions in advanced stage ovarian cancer patients is of utmost importance, since the extent of residual disease after surgery strongly affects survival. Intraoperative imaging may be useful to improve surgery in these patients. Farletuzumab is a humanized IgG1 antibody that specifically recognizes the folate receptor alpha (FRα). Labeled with a radiolabel and a fluorescent dye, farletuzumab may be used for the intraoperative detection of ovarian cancer lesions. The current aim is to demonstrate the feasibility of FRα-targeted dual-modality imaging using (111)In-farletuzumab-IRDye800CW in an intraperitoneal ovarian cancer model...
August 30, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28822300/drinking-water-to-reduce-alcohol-craving-a-randomized-controlled-study-on-the-impact-of-ghrelin-in-mediating-the-effects-of-forced-water-intake-in-alcohol-addiction
#20
Anne Koopmann, Katharina Lippmann, Rilana Schuster, Iris Reinhard, Patrick Bach, Georg Weil, Marcella Rietschel, Stephanie H Witt, Klaus Wiedemann, Falk Kiefer
BACKGROUND: Recent data suggest that ghrelin is involved in the pathophysiology of alcohol use disorders, affecting alcohol self-administration and craving. Gastric ghrelin secretion is reduced by stomach distension. We now tested the hypothesis whether the clinically well-known effects of high-volume water intake on craving reduction in alcoholism is mediated by acute changes in ghrelin secretion. METHODS: In this randomized human laboratory study, we included 23 alcohol-dependent male inpatient subjects who underwent alcohol cue exposure...
August 5, 2017: Psychoneuroendocrinology
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