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https://www.readbyqxmd.com/read/28627315/bioabsorbable-fixation-screw-for-proximal-interphalangeal-arthrodesis-of-lesser-toe-deformities
#1
Jascha Armin Wendelstein, Peter Goger, Peter Bock, Reinhard Schuh, Priv Doz, Hans-Jörg Trnka
BACKGROUND: Although standard fixation of proximal interphalangeal (PIP) arthrodesis by K-wire is relatively inexpensive and well established, it does have some drawbacks, making newer fixation devices interesting. The aim of this study was to clinically and radiologically assess the operative correction of the lesser toe deformation in the form of a PIP arthrodesis using a bioabsorbable 2.7-mm fixation screw. METHODS: From January 2011 until October 2013, 34 patients underwent a PIP arthrodesis using the TRIM-IT (Arthrex) 2...
June 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28623052/how-physicians-draw-satisfaction-and-overcome-barriers-in-their-practices-it-sustains-me
#2
William T Branch, Amy B Weil, MaryAnn C Gilligan, Debra K Litzelman, Janet P Hafler, Margaret Plews-Ogan, Elizabeth A Rider, Lars G Osterberg, Dana Dunne, Arthur R Derse, J Richard Pittman, Richard M Frankel
OBJECTIVE: Major reorganizations of medical practice today challenge physicians' ability to deliver compassionate care. We sought to understand how physicians who completed an intensive faculty development program in medical humanism sustain their humanistic practices. METHODS: Program completers from 8 U.S. medical schools wrote reflections in answer to two open-ended questions addressing their personal motivations and the barriers that impeded their humanistic practice and teaching...
June 8, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28621179/an-integrated-experimental-and-economic-evaluation-of-cell-therapy-affinity-purification-technologies
#3
Benjamin D Weil, Michael J Jenkins, Siddique Uddin, Daniel G Bracewell, Donald Wellings, Suzanne S Farid, Farlan Veraitch
AIM: To present an integrated techno-economic analysis assessing the feasibility of affinity purification technologies using the manufacture of induced pluripotent stem cell-derived progenitor photoreceptors for retinal dystrophies as a case study. MATERIALS & METHODS: Sort purity, progenitor yield and viable cell recovery were investigated for three cell sorting techniques: fluorescent-activated cell sorting (FACS); magnetic-activated cell sorting (MACS); and a novel technology SpheriTech beads...
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28607172/tweety-homologue-1-drives-brain-colonization-of-gliomas
#4
Erik Jung, Matthias Osswald, Jonas Blaes, Benedikt Wiestler, Felix Sahm, Torsten Schmenger, Gergely Solecki, Katrin Deumelandt, Felix T Kurz, Ruifan Xie, Sophie Weil, Oliver Heil, Carina Thomé, Miriam Gömmel, Mustafa Syed, Peter Häring, Peter E Huber, Sabine Heiland, Michael Platten, Andreas von Deimling, Wolfgang Wick, Frank Winkler
Early and progressive colonization of the healthy brain is one hallmark of diffuse gliomas, including glioblastomas. Recently we have discovered ultra-long (> ten to hundreds of microns) membrane protrusions (tumor microtubes, TMs) that are extended by glioma cells. TMs were associated with the capacity of glioma cells to effectively invade the brain, and proliferate. Moreover, TMs were also used by some tumor cells to interconnect to one large, resistant multicellular network. Here, we performed a correlative gene expression microarray and in vivo imaging analysis, and identified novel molecular candidates for TM formation and function...
June 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28601697/approaching-contamination-related-stimuli-with-an-implicit-approach-avoidance-task-can-it-reduce-ocd-symptoms-an-online-pilot-study
#5
Ricarda Weil, Ansgar Feist, Steffen Moritz, Charlotte E Wittekind
BACKGROUND AND OBJECTIVES: Dual-process models suggest that automatic behavioral tendencies contribute to the development and maintenance of Obsessive Compulsive Disorder (OCD) symptoms. The aim of the present study was to investigate the potential of the Approach-Avoidance Task (AAT) to reduce OCD symptoms and associated distress. METHODS: The study was set up as an online intervention. Participants with OCD symptoms (N = 101) were randomly assigned either to one of two experimental conditions or a waitlist control group upon completion of an online baseline survey...
May 30, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28595725/ultrasensitive-detection-of-nucleic-acids-and-proteins-using-quartz-crystal-microbalance-and-surface-plasmon-resonance-sensors-based-on-target-triggering-multiple-signal-amplification-strategy
#6
Wenbo Sun, Weiling Song, Xiaoyan Guo, Zonghua Wang
In this study, quartz crystal microbalance (QCM) and surface plasmon resonance (SPR) sensors were combined with template enhanced hybridization processes (TEHP), rolling circle amplification (RCA) and biocatalytic precipitation (BCP) for ultrasensitive detection of DNA and protein. The DNA complementary to the aptamer was released by the specific binding of the aptamer to the target protein and then hybridized with the capture probe and the assistant DNA to form a ternary "Y" junction structure. The initiation chain was generated by the template-enhanced hybridization process which leaded to the rolling circle amplification reaction, and a large number of repeating unit sequences were formed...
July 25, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28593949/current-induced-skyrmion-generation-and-dynamics-in-symmetric-bilayers
#7
A Hrabec, J Sampaio, M Belmeguenai, I Gross, R Weil, S M Chérif, A Stashkevich, V Jacques, A Thiaville, S Rohart
Magnetic skyrmions are quasiparticle-like textures which are topologically different from other states. Their discovery in systems with broken inversion symmetry sparked the search for materials containing such magnetic phase at room temperature. Their topological properties combined with the chirality-related spin-orbit torques make them interesting objects to control the magnetization at nanoscale. Here we show that a pair of coupled skyrmions of opposite chiralities can be stabilized in a symmetric magnetic bilayer system by combining Dzyaloshinskii-Moriya interaction (DMI) and dipolar coupling effects...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28593479/rna-binding-protein-dnd1-inhibits-epithelial-mesenchymal-transition-and-cancer-stem-cell-related-traits-on-hepatocellular-carcinoma-cells
#8
Weiling Xu, Fangchao Gong, Ting Zhang, Baorong Chi, Jingyu Wang
OBJECTIVES: To investigate the roles of Dead end 1 (Dnd1) in modulating cancer stem cell-related traits of hepatocellular carcinoma (HCC). RESULTS: Dead end (Dnd1) inhibited spheroid formation, suppressed the expression of stemness-related genes, and increased sensitivity to sorafenib in HCC cells. Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP and its cytoplasmic retention...
June 7, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28592676/life-or-death-disease-tolerant-coral-species-activate-autophagy-following-immune-challenge
#9
Lauren E Fuess, Jorge H Pinzón C, Ernesto Weil, Robert D Grinshpon, Laura D Mydlarz
Global climate change has increased the number and severity of stressors affecting species, yet not all species respond equally to these stressors. Organisms may employ cellular mechanisms such as apoptosis and autophagy in responding to stressful events. These two pathways are often mutually exclusive, dictating whether a cell adapts or dies. In order to examine differences in cellular response to stress, we compared the immune response of four coral species with a range of disease susceptibility. Using RNA-seq and novel pathway analysis, we were able to identify differences in response to immune stimulation between these species...
June 14, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28585061/quality-of-life-correlates-with-muscle-strength-in-patients-with-dermato-or-polymyositis
#10
Karina B Poulsen, Helene Alexanderson, Christine Dalgård, Søren Jacobsen, Louise Weile, Louise P Diederichsen
The aim of this study was to compare health-related quality of life (HQoL) in adults with dermatomyositis (DM) or polymyositis (PM) with a healthy control group and to assess whether muscle strength was associated with HQoL in patients with DM or PM. A cross-sectional study was performed and included 75 patients with DM or PM and 48 healthy controls. HQoL was assessed by the Short Form 36 questionnaire (SF-36). Muscle strength of the patients was assessed using the Manual Muscle Test-8 (MMT8). Covariables and possible confounding factors were collected by validated tools...
June 6, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28583952/pursuing-health-equity
#11
EDITORIAL
Alan R Weil
No abstract text is available yet for this article.
June 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28579903/study-on-apoptosis-effect-of-human-breast-cancer-cell-mcf-7-induced-by-lycorine-hydrochloride-via-death-receptor-pathway
#12
Yubin Ji, Miao Yu, Zheng Qi, Di Cui, Guosong Xin, Bing Wang, Weiling Jia, Lin Chang
As research was conducted on the early apoptosis of human breast cancer cell MCF-7 caused by lycorine hydrochloride and the expression of the related apoptosis proteins. The early-period apoptosis rate of human breast cancer cell MCF-7 was tested with the AnnexinV/PI double staining and flow cytometry. The Western Blotting method was also used to detect the protein expression conditions of Fas, FasL, Caspase-8 and Bid. The results showed that the higher the dose, the higher the rate of apoptosis and that the rate of apoptosis was dependent on the dose; the relative protein activity of Fas, FasL, Caspase-8 and bid gradually rose with the increase of lycorine dosage and the activities revealed certain dose-independence...
May 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28579126/forefoot-adduction-is-a-risk-factor-for-jones-fracture
#13
Adam E Fleischer, Rebecca Stack, Erin E Klein, Jeffrey R Baker, Lowell Weil, Lowell Scott Weil
Jones fractures are among the most common fractures of the foot; however, much remains unknown about their etiology. The purpose of the present study was to further examine the risk factors of forefoot and hindfoot alignment on Jones fractures using an epidemiologic study design. We used a retrospective, matched, case-control study design. Cases consisted of patients with acute, isolated Jones fractures confirmed on plain film radiographs seen at our institute from January 2009 to December 2013. Patients presenting with pain unrelated to metatarsal fractures served as controls...
May 31, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28575053/mxi1-0-regulates-the-growth-of-human-umbilical-vein-endothelial-cells-through-extracellular-signal-regulated-kinase-1-2-erk1-2-and-interleukin-8-il-8-dependent-pathways
#14
Weiling Wu, Zhenzhen Hu, Feng Wang, Hao Gu, Xiuqin Jiang, Jinjin Xu, Xi Zhan, Datong Zheng, Zhengdong Zhang
Mxi1 plays an important role in the regulation of cell proliferation. Mxi1-0, a Mxi1 isoform, has a different N-terminal amino acid sequence, intracellular location and expression profile from Mxi1. However, the precise role of Mxi1-0 in cell proliferation and the molecular mechanism underlying its function remain poorly understood. Here, we showed that Mxi1-0 suppression decreased the proliferation of human umbilical vein endothelial cells (HUVECs) along with cell accumulation in the G2/M phase. Mxi1-0 suppression also significantly decreased the expression and secretion of interleukin (IL-8)...
2017: PloS One
https://www.readbyqxmd.com/read/28573392/remembering-vivian-weil
#15
Rachelle D Hollander, Michael Davis, Deni Elliott, Michael S Pritchard
No abstract text is available yet for this article.
June 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28573187/the-risk-of-transplant-failure-with-hla-mismatch-in-first-adult-kidney-allografts-2-living-donors-summary-guide
#16
Robert C Williams, Gerhard Opelz, E Jennifer Weil, Chelsea J McGarvey, Harini A Chakkera
BACKGROUND: Allografts from living donors survive longer than those from deceased donors but the role of HLA mismatching in living kidney donation is still in question. We examined the effect of HLA compatibility on kidney allograft survival from living donors by studying all first adult kidney transplants performed in the United States over 25 years. METHODS: Using the United Network for Organ Sharing data, we identified first kidney transplants between October 1, 1987, and December 31, 2013...
May 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28571726/anti-tumor-effect-of-scutellaria-barbata-d-don-extracts-on-ovarian-cancer-and-its-phytochemicals-characterisation
#17
Lin Zhang, Baoyin Ren, Jing Zhang, Likun Liu, Jia Liu, Guoqiang Jiang, Man Li, Yuejia Ding, Weiling Li
ETHNOPHARMACOLOGICAL RELEVANCE: Scutellaria barbata D. Don is a widely used medicinal herb in China. It possess various medicinal properties including antioxidative, anti-inflammatory and anti-cancer effects. The aim of this study was to explore whether Scutellaria barbata D. Don could inhibit the growth of ovarian cancer cells in vitro and further investigate the underlying mechanisms. MATERIALS AND METHODS: Effects of Scutellaria barbata D. Don on the viability of ovarian cancer A2780 cells were measured by MTT assay...
May 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28567666/serum-protein-based-profiles-as-novel-biomarkers-for-the-diagnosis-of-alzheimer-s-disease
#18
Shu Yu, Yue-Ping Liu, Hai-Liang Liu, Jie Li, Yang Xiang, Yu-Hui Liu, Shu-Sheng Jiao, Lu Liu, Yajiang Wang, Weiling Fu
As a multi-stage disorder, Alzheimer's disease (AD) is quickly becoming one of the most prevalent neurodegenerative diseases worldwide. Thus, a non-invasive, serum-based diagnostic platform is eagerly awaited. The goal of this study was to identify a serum-based biomarker panel using a predictive protein-based algorithm that is able to confidently distinguish AD patients from control subjects. One hundred and fifty-six patients with AD and the same number of gender- and age-matched control participants with standardized clinical assessments and neuroimaging measures were evaluated...
May 31, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28566492/functional-evidence-for-derivation-of-systemic-histiocytic-neoplasms-from-hematopoietic-stem-progenitor-cells
#19
Benjamin H Durham, Damien Roos-Weil, Claude Baillou, Fleur Cohen-Aubart, Akihide Yoshimi, Makoto Miyara, Matthias Papo, Zofia Hélias-Rodzewicz, Nathalie Terrones, Neval Ozkaya, Ahmet Dogan, Raajit Rampal, Fanny Urbain, Lucie Le Fèvre, Eli L Diamond, Christopher Y Park, Thomas Papo, Frédéric Charlotte, Guy Gorochov, Valérie Taly, Olivier A Bernard, Zahir Amoura, Omar Abdel-Wahab, François M Lemoine, Julien Haroche, Jean-Francois Emile
Langerhans Cell Histiocytosis (LCH) and the non-LCH neoplasm Erdheim-Chester Disease (ECD) are heterogeneous neoplastic disorders marked by infiltration of pathologic macrophage-, dendritic cell-, or monocyte-derived cells in tissues driven by recurrent mutations activating MAP kinase signaling. Although recent data indicate that at least a proportion of LCH and ECD patients have detectable activating kinase mutations in circulating hematopoietic cells and bone marrow-based hematopoietic progenitors, functional evidence of the cell-of-origin of histiocytosis from actual patient materials has long been elusive...
May 31, 2017: Blood
https://www.readbyqxmd.com/read/28565809/clinical-study-on-the-association-between-pregnancy-induced-hypertension-and-insulin-resistance
#20
Zhifang Chen, Weiling Liu, Xiaoqin Sun, Lingling Zhu
The aim of the present study was to explore the association between pregnancy-induced hypertension (PIH) and insulin resistance (IR). A total of 50 cases of PIH and 50 healthy pregnant women with a similar gestational age were enrolled. The hyperinsulinemic-euglycemic clamp technique was used to evaluate the degree of IR and all 100 subjects were divided into an IR and a non-IR group accordingly. Subsequently, the correlation between the systolic or diastolic blood pressure was assessed; furthermore, a homeostasis model assessment of IR (HOMA-IR), a HOMA of the insulin sensitivity index (HOMA-ISI) and a HOMA of β cell function (HOMA-β%) were performed...
May 2017: Experimental and Therapeutic Medicine
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