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https://www.readbyqxmd.com/read/29791853/p27-kip1-modulates-axonal-transport-by-regulating-%C3%AE-tubulin-acetyltransferase-1-stability
#1
Giovanni Morelli, Aviel Even, Ivan Gladwyn-Ng, Romain Le Bail, Michal Shilian, Juliette D Godin, Elise Peyre, Bassem A Hassan, Arnaud Besson, Jean-Michel Rigo, Miguel Weil, Bert Brône, Laurent Nguyen
The protein p27Kip1 plays roles that extend beyond cell-cycle regulation during cerebral cortex development, such as the regulation of neuronal migration and neurite branching via signaling pathways that converge on the actin and microtubule cytoskeletons. Microtubule-dependent transport is essential for the maturation of neurons and the establishment of neuronal connectivity though synapse formation and maintenance. Here, we show that p27Kip1 controls the transport of vesicles and organelles along the axon of mice cortical projection neurons in vitro...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791814/case-16-2018-a-45-year-old-man-with-fever-thrombocytopenia-and-elevated-aminotransferase-levels
#2
Kimiyoshi J Kobayashi, Ana A Weil, John A Branda
Presentation of Case. Dr. Alyssa Sclafani (Medicine): A 45-year-old man presented to the emergency department of this hospital during the summer with fever, thrombocytopenia, and elevated aminotransferase levels. Three weeks before presentation, fever occurred (with temperatures as high as 40.0°C),..
May 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29784530/triplane-hallux-abducto-valgus-classification
#3
REVIEW
Daniel J Hatch, Robert D Santrock, Bret Smith, Paul Dayton, Lowell Weil
One of the most common procedures performed in the foot and ankle is correction of hallux abducto valgus deformity or "bunion surgery." Most foot and ankle surgeons recognize the challenges associated with defining each patient's individual deformity and selecting the optimal procedure for the best long-term results. Using current 2-dimensional algorithms that focus on the severity of the transverse plane deformity, surgical outcomes have varied. In the past 10 years, high recurrence and complication rates for popular procedures have been reported...
May 18, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29773756/mir126-5p-down-regulation-facilitates-axon-degeneration-and-nmj-disruption-via-a-non-cell-autonomous-mechanism-in-als
#4
Roy Maimon, Ariel Ionescu, Avichai Bonnie, Sahar Sweetat, Shane Wald-Altman, Shani Inbar, Tal Gradus, Davide Trotti, Miguel Weil, Oded Behar, Eran Perlson
Axon degeneration and disruption of neuromuscular junctions (NMJs) are key events in Amyotrophic Lateral Sclerosis (ALS) pathology. Although the disease's etiology is not fully understood, it is thought to involve a non-cell-autonomous mechanism and alterations in RNA metabolism. Here, we identified reduced levels of miR-126-5p in pre-symptomatic ALS male mice models, and an increase in its targets: axon destabilizing type-3 Semaphorins and their co-receptor Neuropilins. Utilizing compartmentalized in vitro co-cultures, we demonstrated that myocytes expressing diverse ALS-causing mutations promote axon degeneration and NMJ dysfunction, which were inhibited by applying Neuropilin1 (NRP1) blocking antibody...
May 17, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29768412/adverse-events-following-single-dose-treatment-of-lymphatic-filariasis-observations-from-a-review-of-the-literature
#5
Philip J Budge, Carly Herbert, Britt Andersen, Gary J Weil
BACKGROUND: WHO's Global Programme to Eliminate Lymphatic Filariasis (LF) uses mass drug administration (MDA) of anthelmintic medications to interrupt LF transmission in endemic areas. Recently, a single dose combination of ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB) was shown to be markedly more effective than the standard two-drug regimens (DEC or IVM, plus ALB) for achieving long-term clearance of microfilaremia. OBJECTIVE AND METHODS: To provide context for the results of a large-scale, international safety trial of MDA using triple drug therapy, we searched Ovid Medline for studies published from 1985-2017 that reported adverse events (AEs) following treatment of LF with IVM, DEC, ALB, or any combination of these medications...
May 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29760557/uca1-promotes-cell-proliferation-and-invasion-and-inhibits-apoptosis-through-regulation-of-the-mir129-sox4-pathway-in-renal-cell-carcinoma
#6
Qian Liu, Yang Li, Weiling Lv, Guangwei Zhang, Xin Tian, Xiaodong Li, Hepeng Cheng, Chaoyang Zhu
Background: Renal cell carcinoma (RCC) is the most common cancer in kidney malignancies. UCA1 has been identified as an oncogenic lncRNA in multiple cancers, including RCC. However, the underlying molecular mechanism of UCA1 involved in RCC progression is far from being addressed. Methods: Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) assays were used to measure expressions of UCA1, miR129, and SOX4 mRNA. Western blot assays were employed to detect SOX4 protein expression...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29758000/degree-of-freedom-strengthened-cascade-array-for-dod-doa-estimation-in-mimo-array-systems
#7
Bobin Yao, Zhi Dong, Weile Zhang, Wei Wang, Qisheng Wu
In spatial spectrum estimation, difference co-array can provide extra degrees-of-freedom (DOFs) for promoting parameter identifiability and parameter estimation accuracy. For the sake of acquiring as more DOFs as possible with a given number of physical sensors, we herein design a novel sensor array geometry named cascade array. This structure is generated by systematically connecting a uniform linear array (ULA) and a non-uniform linear array, and can provide more DOFs than some exist array structures but less than the upper-bound indicated by minimum redundant array (MRA)...
May 14, 2018: Sensors
https://www.readbyqxmd.com/read/29755350/extracts-from-hypericum-hircinum-subsp-majus-exert-antifungal-activity-against-a-panel-of-sensitive-and-drug-resistant-clinical-strains
#8
Noemi Tocci, Daniele Perenzoni, Duilio Iamonico, Francesca Fava, Tobias Weil, Fulvio Mattivi
During the last two decades incidences of fungal infections dramatically increased and the often accompanying failure of available antifungal therapies represents a substantial clinical problem. The urgent need for novel antimycotics called particular attention to the study of natural products. The genus Hypericum includes many species that are used in the traditional medicine to treat pathological states like inflammations and infections caused by fungi. However, despite the diffused use of Hypericum -based products the antifungal potential of the genus is still poorly investigated...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29740787/healthcare-at-the-crossroads-the-need-to-shape-an-organizational-culture-of-humanistic-teaching-and-practice
#9
Elizabeth A Rider, MaryAnn C Gilligan, Lars G Osterberg, Debra K Litzelman, Margaret Plews-Ogan, Amy B Weil, Dana W Dunne, Janet P Hafler, Natalie B May, Arthur R Derse, Richard M Frankel, William T Branch
BACKGROUND: Changes in the organization of medical practice have impeded humanistic practice and resulted in widespread physician burnout and dissatisfaction. OBJECTIVE: To identify organizational factors that promote or inhibit humanistic practice of medicine by faculty physicians. DESIGN: From January 1, 2015, through December 31, 2016, faculty from eight US medical schools were asked to write reflectively on two open-ended questions regarding institutional-level motivators and impediments to humanistic practice and teaching within their organizations...
May 8, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29737368/-minimally-invasive-correction-of-lesser-toe-deformities-and-treatment-of-metatarsalgia
#10
REVIEW
M Thomas, M Jordan
OBJECTIVE: Atraumatic and joint-sparing procedure for the correction of lesser toe deformities by using a linear or perpendicular osteotomy of the proximal and/or middle phalanx of the lesser toes with additional capsulotomies or tendon dissection for soft tissue realignment. Metatarsalgia is addressed via an extracapsular distal metaphyseal crescentic-like metatarsal osteotomy. INDICATIONS: Symptomatic lesser toe deformities, painful pseudoexostosis, metatarsalgia, symptomatic metatarsal malalignment, metatarsus adductus...
May 8, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29734283/how-does-electronic-health-information-exchange-affect-hospital-performance-efficiency-the-effects-of-breadth-and-depth-of-information-sharing
#11
Na-Eun Cho, Weiling Ke, Bebonchu Atems, Jongwha Chang
This research was motivated by the large investment in health information technology (IT) by hospitals and the inconsistent findings related to the effects of health IT adoption on hospital performance. Building on resource orchestration theory and the information systems literature, the authors developed a research model to investigate how the configuration strategies for sharing information under health IT systems affect hospital efficiency. The hypotheses were tested using data from the 2010 annual and IT surveys of the American Hospital Association, Centers for Medicare & Medicaid Services case mix index, and U...
May 2018: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/29733714/precision-medicine
#12
Alan R Weil
No abstract text is available yet for this article.
May 2018: Health Affairs
https://www.readbyqxmd.com/read/29733502/natural-killer-cell-immunotherapy-against-multiple-myeloma-progress-and-possibilities
#13
REVIEW
Pan Liu, Yanxia Jin, Haseeb Sattar, Hailing Liu, Weiling Xie, Fuling Zhou
Multiple myeloma (MM) is a complex aggressive mature B-cell malignancy. Although with the wide application of chemotherapy drugs, it remains incurable and the vast majority of patients relapse. Natural killer (NK) cells, also known as CD56+ CD3- large granular lymphocytes, are cytotoxic innate immune cells against MM without prior sensitization steps. NK cell-based immunotherapy is extensively promising in a wide range of clinical settings. It is worthy of note that some novel drugs such as monoclonal antibodies (mAbs), proteasome inhibitors (PIs), and immunomodulators (IMiDs) directly or indirectly activate NK cells to enhance their antitumor activity, and the combined regimens significantly improve the prognosis of MM patients...
May 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29726390/the-my-child-matters-programme-effect-of-public-private-partnerships-on-paediatric-cancer-care-in-low-income-and-middle-income-countries
#14
REVIEW
Scott C Howard, Alia Zaidi, Xueyuan Cao, Olivier Weil, Pierre Bey, Catherine Patte, Angelica Samudio, Laurie Haddad, Catherine G Lam, Claude Moreira, Augusto Pereira, Mhamed Harif, Laila Hessissen, Salma Choudhury, Ligia Fu, Miguela A Caniza, Julius Lecciones, Fousseyni Traore, Raul C Ribeiro, Anne Gagnepain-Lacheteau
In low-income and middle-income countries, an excess in treatment failure for children with cancer usually results from misdiagnosis, inadequate access to treatment, death from toxicity, treatment abandonment, and relapse. The My Child Matters programme of the Sanofi Espoir Foundation has funded 55 paediatric cancer projects in low-income and middle-income countries over 10 years. We assessed the impact of the projects in these regions by using baseline assessments that were done in 2006. Based on these data, estimated 5-year survival in 2016 increased by a median of 5·1%, ranging from -1·5% in Venezuela to 17·5% in Ukraine...
May 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29724590/cement-augmentation-of-the-proximal-femoral-nail-antirotation-pfna-a-multicentre-randomized-controlled-trial
#15
Christian Kammerlander, Einar S Hem, Tim Klopfer, Florian Gebhard, An Sermon, Michael Dietrich, Olaf Bach, Yoram Weil, Reto Babst, Michael Blauth
INTRODUCTION: New implant designs like the Proximal Femoral Nail Antirotation (PFNA) were developed to reduce failure rates in unstable pertrochanteric fractures in the elderly. Standardized implant augmentation with up to 6 mL of polymethylmethacrylate (PMMA) cement has been introduced to enhance implant anchorage by increasing the implant-bone interface in osteoporotic bone conditions. Biomechanically, loads to failure were significantly higher with augmentation. The primary objective of this study was to compare the mobility of patients with closed unstable trochanteric fractures treated by PFNA either with or without cement augmentation...
April 22, 2018: Injury
https://www.readbyqxmd.com/read/29710212/effectiveness-of-low-doses-of-hyaluronidase-to-remove-hyaluronic-acid-filler-nodules-a-randomized-clinical-trial
#16
Murad Alam, Rosemara Hughart, Amelia Geisler, Kapila Paghdal, Amanda Maisel, Alexandra Weil, Dennis P West, Emir Veledar, Emily Poon
Importance: Although hyaluronidase is known to remove hyaluronic acid fillers, use of low doses has not been well studied. Objective: To assess the effectiveness and dose-related effect of small quantities of hyaluronidase to treat hyaluronic acid filler nodules. Design, Setting, and Participants: Split-arm, parallel-group, randomized clinical trial at an urban academic center. Participants were 9 healthy women. Recruitment and follow-up occurred from February 2013 to March 2014; data analysis occurred from February to July 2016...
April 25, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29706479/scrub-typhus-diagnosis-on-acute-specimens-using-serological-and-molecular-assays-a-3-year-prospective-study
#17
Munegowda Koralur, Rahul Singh, Muralidhar Varma, Shalini Shenoy, Vasudeva Acharya, Asha Kamath, John Stenos, Eugen Athan, Indira Bairy
Scrub typhus (ST) is an underdiagnosed acute febrile illness in the Asia Pacific region with recent reemergence. Clinical diagnosis is difficult, and laboratory confirmation is largely based on serological and molecular tests. However, Weil-Felix test still remains the only test available in much of the rural tropics where a disproportionate number of cases occur. Sensitive and affordable assays are important for broader use and accurate diagnosis. We evaluated the diagnostic capabilities of serological and molecular assays on single acute clinical samples...
February 24, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29705242/epithelial-barrier-dysfunction-in-desmoglein-1-deficiency
#18
Laura Polivka, Smail Hadj-Rabia, Elodie Bal, Stéphanie Leclerc-Mercier, Marine Madrange, Yamina Hamel, Damien Bonnet, Stéphanie Mallet, Hubert Lepidi, Caroline Ovaert, Patrick Barbet, Christophe Dupont, Bénédicte Neven, Arnold Munnich, Lisa M Godsel, Florence Campeotto, Robert Weil, Emmanuel Laplantine, Sylvie Marchetto, Jean-Paul Borg, William I Weis, Jean-Laurent Casanova, Anne Puel, Kathleen J Green, Christine Bodemer, Asma Smahi
Desmoglein-1 deficiency is a missing link between impaired epithelial barrier function and immunological dysregulation. Our characterization of SAMEC syndrome highlighted the pivotal role of the desmoglein-1/ERBIN interaction as an inhibitor of skin inflammation via the NF-κB signaling pathway.
April 26, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29704848/trichloroethene-tce-hydrodechlorination-by-nife-nanoparticles-influence-of-aqueous-anions-on-catalytic-pathways
#19
Yanlai Han, Changjie Liu, Juske Horita, Weile Yan
Amending bulk and nanoscale zero-valent iron (ZVI) with catalytic metals significantly accelerates hydrodechlorination of groundwater contaminants such as trichloroethene (TCE). The bimetallic design benefits from a strong synergy between Ni and Fe in facilitating the production of active hydrogen for TCE reduction, and it is of research and practical interest to understand the impacts of common groundwater solutes on catalyst and ZVI functionality. In this study, TCE hydrodechlorination reaction was conducted using fresh NiFe bimetallic nanoparticles (NiFe BNPs) and those aged in chloride, sulfate, phosphate, and humic acid solutions with concurrent analysis of carbon fractionation of TCE and its daughter products...
April 16, 2018: Chemosphere
https://www.readbyqxmd.com/read/29698710/subcutaneous-infiltration-of-carbon-dioxide-carboxytherapy-for-abdominal-fat-reduction-a-randomized-clinical-trial
#20
Murad Alam, Divya Sadhwani, Amelia Geisler, Imran Aslam, Inder Raj S Makin, Daniel I Schlessinger, Wareeporn Disphanurat, Marisa Pongprutthipan, Nataya Voravutinon, Alexandra Weil, Brian R Chen, Dennis P West, Emir Veledar, Emily Poon
BACKGROUND: Non-invasive fat removal is preferred because of decreased downtime and lower perceived risk. It is important to seek new non-invasive fat removal treatments that are both safe and efficacious. OBJECTIVE: To assess the extent to which carboxytherapy, the insufflation of carbon dioxide gas into subcutaneous fat, results in reduction of fat volume. METHODS: Randomized, sham-controlled, split-body study. Adults (BMI 22-29) were randomized to receive five weekly infusions of 1000 cc CO2 to one side of the abdomen, and five sham treatments to the contralateral side...
April 23, 2018: Journal of the American Academy of Dermatology
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