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https://www.readbyqxmd.com/read/28329751/conservative-management-of-large-traumatic-supratentorial-epidural-hematoma-in-the-pediatric-population
#1
Pierre-Olivier Champagne, Kevin Xiaho He, Claude Mercier, Alexander G Weil, Louis Crevier
BACKGROUND/AIMS: Conservative management of traumatic epidural hematomas is being recognized as a safe alternative to surgical treatment in asymptomatic children. There is still debate about the maximal size of epidural hematoma that should be tolerated before deciding for surgery. METHODS: We report - through a retrospective cohort study from a single institution - a series of 16 conservatively managed traumatic epidural hematomas of more than 15 mm thickness. RESULTS: 14 patients (88%) were successfully treated using conservative management...
March 23, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28323712/trends-in-inpatient-vertebroplasty-and-kyphoplasty-volume-in-the-united-states-2005-2011-assessing-the-impact-of-randomized-controlled-trials
#2
Benjamin P Rosenbaum, Varun R Kshettry, Michael L Kelly, Thomas E Mroz, Robert J Weil
STUDY DESIGN: Retrospective analysis of the Nationwide Inpatient Sample, 2005-2011. OBJECTIVE: To identify trends in procedural volume and rates in the time period surrounding publication of randomized controlled trials (RCTs) that examined the utility of vertebroplasty and kyphoplasty. SUMMARY OF BACKGROUND DATA: Vertebroplasty and kyphoplasty are frequently performed for vertebral compression fractures. Several RCTs have been published with conflicting outcomes regarding pain and quality of life compared with nonsurgical management and sham procedures...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28322704/transmission-of-hepatitis-a-virus-through-combined-liver-small-intestine-pancreas-transplantation
#3
Monique A Foster, Lauren M Weil, Sherry Jin, Thomas Johnson, Tonya R Hayden-Mixson, Yury Khudyakov, Pallavi D Annambhotla, Sridhar V Basavaraju, Saleem Kamili, Jana M Ritter, Noele Nelson, George Mazariegos, Michael Green, Ryan W Himes, David T Kuhar, Matthew J Kuehnert, Jeffrey A Miller, Rachel Wiseman, Anne C Moorman
Although transmission of hepatitis A virus (HAV) through blood transfusion has been documented, transmission through organ transplantation has not been reported. In August 2015, state health officials in Texas, USA, were notified of 2 home health nurses with HAV infection whose only common exposure was a child who had undergone multi-visceral organ transplantation 9 months earlier. Specimens from the nurses, organ donor, and all organ recipients were tested and medical records reviewed to determine a possible infection source...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28321803/prognosis-of-cirrhotic-patients-admitted-to-intensive-care-unit-a-meta-analysis
#4
Delphine Weil, Eric Levesque, Marc McPhail, Rodrigo Cavallazzi, Eleni Theocharidou, Evangelos Cholongitas, Arnaud Galbois, Heng Chih Pan, Constantine J Karvellas, Bertrand Sauneuf, René Robert, Jérome Fichet, Gaël Piton, Thierry Thevenot, Gilles Capellier, Vincent Di Martino
BACKGROUND: The best predictors of short- and medium-term mortality of cirrhotic patients receiving intensive care support are unknown. METHODS: We conducted meta-analyses from 13 studies (2523 cirrhotics) after selection of original articles and response to a standardized questionnaire by the corresponding authors. End-points were in-ICU, in-hospital, and 6-month mortality in ICU survivors. A total of 301 pooled analyses, including 95 analyses restricted to 6-month mortality among ICU survivors, were conducted considering 249 variables (including reason for admission, organ replacement therapy, and composite prognostic scores)...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28304218/comparative-effectiveness-of-flexible-versus-rigid-neuroendoscopy-for-endoscopic-third-ventriculostomy-and-choroid-plexus-cauterization-a-propensity-score-matched-cohort-and-survival-analysis
#5
Shelly Wang, Scellig Stone, Alexander G Weil, Aria Fallah, Benjamin C Warf, John Ragheb, Sanjiv Bhatia, Abhaya V Kulkarni
OBJECTIVE Endoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score-matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid neuroendoscopy. METHODS Individual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid neuroendoscopy...
March 17, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28300392/generation-and-characterization-of-virus-infection-enhancing-peptide-nanofibrils-functionalized-with-fluorescent-labels
#6
Sascha Rode, Manuel Hayn, Annika Röcker, Stefanie Sieste, Marcus Lamla, Daniel Markx, Christoph Meier, Frank Kirchhoff, Paul Walther, Marcus Fändrich, Tanja Weil, Jan Muench
Retroviral gene transfer is the method of choice for the stable introduction of genetic material into the cellular genome. However, efficient gene transfer is often limited by low transduction rates of the viral vectors. We have recently described a 12-mer peptide, termed EF-C that forms amyloid-like peptide nanofibrils (PNF) strongly increasing viral transduction efficiencies. These nanofibrils are polycationic and bind negatively charged membranes of virions and cells, thereby overcoming charge repulsions and resulting in increased rates of virion attachment and gene transfer...
March 16, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28295562/locked-nucleic-acid-lna-based-single-stranded-oligonucleotides-are-not-genotoxic
#7
Guérard Melanie, Zeller Andreas, Koller Erich, Marchand Christine, Müller B Martina, Weile Christian, Schuler Franz, Singer Thomas, Tessier Yann
Over the last decade, single stranded oligonucleotides (ON) have gained increased attention as a new drug modality. Because the assessment of genotoxicity risk during early development of pharmaceuticals is essential, we evaluated the potential of locked nucleic acids (LNA)-ONs to induce DNA damage in L5178Y tk(+/-) cells both with the mouse lymphoma assay (MLA) and the micronucleus test (MNT). Further, the MLA was performed to assess gene and chromosome mutation over 3 and 24h (± metabolic activation). In addition, the MNT was performed to assess, in addition, a potential aneugenic liability...
March 10, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28295373/building-a-better-foundation-improving-root-trait-measurements-to-understand-and-model-plant-and-ecosystem-processes
#8
M Luke McCormack, Dali Guo, Colleen M Iversen, Weile Chen, David M Eissenstat, Christopher W Fernandez, Le Li, Chengen Ma, Zeqing Ma, Hendrik Poorter, Peter B Reich, Marcin Zadworny, Amy Zanne
Trait-based approaches provide a useful framework to investigate plant strategies for resource acquisition, growth, and competition, as well as plant impacts on ecosystem processes. Despite significant progress capturing trait variation within and among stems and leaves, identification of trait syndromes within fine-root systems and between fine roots and other plant organs is limited. Here we discuss three underappreciated areas where focused measurements of fine-root traits can make significant contributions to ecosystem science...
March 13, 2017: New Phytologist
https://www.readbyqxmd.com/read/28290206/diverse-applications-of-nanomedicine
#9
Beatriz Pelaz, Christoph Alexiou, Ramon A Alvarez-Puebla, Frauke Alves, Anne M Andrews, Sumaira Ashraf, Lajos P Balogh, Laura Ballerini, Alessandra Bestetti, Cornelia Brendel, Susanna Bosi, Monica Carril, Warren C W Chan, Chunying Chen, Xiaodong Chen, Xiaoyuan Chen, Zhen Cheng, Daxiang Cui, Jianzhong Du, Christian Dullin, Alberto Escudero, Neus Feliu, Mingyuan Gao, Michael George, Yury Gogotsi, Arnold Grünweller, Zhongwei Gu, Naomi J Halas, Norbert Hampp, Roland K Hartmann, Mark C Hersam, Patrick Hunziker, Ji Jian, Xingyu Jiang, Philipp Jungebluth, Pranav Kadhiresan, Kazunori Kataoka, Ali Khademhosseini, Jindřich Kopeček, Nicholas A Kotov, Harald F Krug, Dong Soo Lee, Claus-Michael Lehr, Kam W Leong, Xing-Jie Liang, Mei Ling Lim, Luis M Liz-Marzán, Xiaowei Ma, Paolo Macchiarini, Huan Meng, Helmuth Möhwald, Paul Mulvaney, Andre E Nel, Shuming Nie, Peter Nordlander, Teruo Okano, Jose Oliveira, Tai Hyun Park, Reginald M Penner, Maurizio Prato, Victor Puntes, Vincent M Rotello, Amila Samarakoon, Raymond E Schaak, Youqing Shen, Sebastian Sjöqvist, Andre G Skirtach, Mahmoud G Soliman, Molly M Stevens, Hsing-Wen Sung, Ben Zhong Tang, Rainer Tietze, Buddhisha N Udugama, J Scott VanEpps, Tanja Weil, Paul S Weiss, Itamar Willner, Yuzhou Wu, Lily Yang, Zhao Yue, Qian Zhang, Qiang Zhang, Xian-En Zhang, Yuliang Zhao, Xin Zhou, Wolfgang J Parak
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. using biological, nonbiological, biomimetic, or hybrid materials. Many of these developments are starting to be translated into viable clinical products...
March 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28288949/evaluation-of-the-pharmacokinetics-and-efficacy-of-a-busulfan-test-dose-in-adult-patients-undergoing-myeloablative-hematopoietic-cell-transplant
#10
Elizabeth Weil, Felicia Zook, Carolyn Oxencis, Angela Canadeo, Angela Urmanski, Mindy Waggoner, Daniel Eastwood, Marcelo Pasquini, Mehdi Hamadani, Parameswaran Hari
Due to inter-patient variability in busulfan exposure, therapeutic monitoring of busulfan is often employed in myeloablative allogeneic transplantation to ensure that patients are near the optimal steady state goal of 900 ng/mL. One challenge with therapeutic monitoring of busulfan is the brief course of treatment busulfan is administered over, so prompt analysis and dose adjustments are necessary. Pharmacokinetic evaluation of a busulfan test dose prior to beginning the conditioning regimen would allow for all conditioning regimen doses to be given at the calculated optimized dose...
March 10, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28283029/legal-immigrants-invasion-of-alien-microbial-communities-during-winter-occurring-desert-dust-storms
#11
Tobias Weil, Carlotta De Filippo, Davide Albanese, Claudio Donati, Massimo Pindo, Lorenzo Pavarini, Federico Carotenuto, Massimiliano Pasqui, Luisa Poto, Jacopo Gabrieli, Carlo Barbante, Birgit Sattler, Duccio Cavalieri, Franco Miglietta
BACKGROUND: A critical aspect regarding the global dispersion of pathogenic microorganisms is associated with atmospheric movement of soil particles. Especially, desert dust storms can transport alien microorganisms over continental scales and can deposit them in sensitive sink habitats. In winter 2014, the largest ever recorded Saharan dust event in Italy was efficiently deposited on the Dolomite Alps and was sealed between dust-free snow. This provided us the unique opportunity to overcome difficulties in separating dust associated from "domestic" microbes and thus, to determine with high precision microorganisms transported exclusively by desert dust...
March 10, 2017: Microbiome
https://www.readbyqxmd.com/read/28282092/nir-emitting-and-photo-thermal-active-nanogold-as-mitochondria-specific-probes
#12
Sabyasachi Chakrabortty, Miguel Sison, Yuzhou Wu, Anita Ladenburger, Goutam Pramanik, Johannes Biskupek, Jerome Extermann, Ute Kaiser, Theo Lasser, Tanja Weil
We report a bioinspired multifunctional albumin derived polypeptide coating comprising grafted poly(ethylene oxide) chains, multiple copies of the HIV TAT derived peptide enabling cellular uptake as well as mitochondria targeting triphenyl-phosphonium (TPP) groups. Exploring these polypeptide copolymers for passivating gold nanoparticles (Au NPs) yielded (i) NIR-emitting markers in confocal microscopy and (ii) photo-thermal active probes in optical coherence microscopy. We demonstrate the great potential of such multifunctional protein-derived biopolymer coatings for efficiently directing Au NP into cells and to subcellular targets to ultimately probe important cellular processes such as mitochondria dynamics and vitality inside living cells...
March 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28277933/role-and-convergent-evolution-of-competing-rna-secondary-structures-in-mutually-exclusive-splicing
#13
Yuan Yue, Shouqing Hou, Xiu Wang, Leilei Zhan, Guozheng Cao, Guoli Li, Yang Shi, Peng Zhang, Weiling Hong, Hao Lin, Baoping Liu, Feng Shi, Yun Yang, Yongfeng Jin
Exon or cassette duplication is an important means of expanding protein and functional diversity through mutually exclusive splicing. However, the mechanistic basis of this process in non-arthropod species remains poorly understood. Here, we demonstrate that MRP1 genes underwent tandem exon duplication in Nematoda, Platyhelminthes, Annelida, Mollusca, Arthropoda, Echinodermata, and early-diverging Chordata but not in late-diverging vertebrates. Interestingly, these events were of independent origin in different phyla, suggesting convergent evolution of alternative splicing...
February 17, 2017: RNA Biology
https://www.readbyqxmd.com/read/28265841/surgical-outcomes-in-patients-with-cushing-s-disease-the-cleveland-clinic-experience
#14
Philip C Johnston, Laurence Kennedy, Amir H Hamrahian, Zahrae Sandouk, James Bena, Betul Hatipoglu, Robert J Weil
CONTEXT: Transsphenoidal surgery (TSS) to resect a pituitary adenoma is considered first-line treatment for patients with Cushing's disease (CD). Early, post-operative remission rates >80% are expected for patients with a microadenoma (≤ 10 mm) visible on magnetic resonance (MR) imaging. OBJECTIVE: To report surgical outcomes and predictors of remission in a specialist center for patients with CD. PATIENTS AND METHODS: Clinical data was obtained from a prospective CD database in addition to review of all electronic medical, laboratory and surgical patient records...
March 6, 2017: Pituitary
https://www.readbyqxmd.com/read/28264937/delivery-system-innovation
#15
EDITORIAL
Alan R Weil
No abstract text is available yet for this article.
March 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28260145/effects-of-pyrite-and-sphalerite-on-population-compositions-dynamics-and-copper-extraction-efficiency-in-chalcopyrite-bioleaching-process
#16
Yunhua Xiao, Xueduan Liu, Weiling Dong, Yili Liang, Jiaojiao Niu, Yabing Gu, Liyuan Ma, Xiaodong Hao, Xian Zhang, Zhen Xu, Huaqun Yin
This study used an artificial microbial community with four known moderately thermophilic acidophiles (three bacteria including Acidithiobacillus caldus S1, Sulfobacillus thermosulfidooxidans ST and Leptospirillum ferriphilum YSK, and one archaea, Ferroplasma thermophilum L1) to explore the variation of microbial community structure, composition, dynamics and function (e.g., copper extraction efficiency) in chalcopyrite bioleaching (C) systems with additions of pyrite (CP) or sphalerite (CS). The community compositions and dynamics in the solution and on the ore surface were investigated by real-time quantitative PCR (qPCR)...
March 4, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28258571/aquaporins-in-urinary-system
#17
Yingjie Li, Weiling Wang, Tao Jiang, Baoxue Yang
Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells. AQP2 is the vasopressin-regulated water channel that is important in hereditary and acquired diseases affecting urine-concentrating ability. The roles of AQPs in renal physiology and transepithelial water transport have been determined using AQP knockout mouse models...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28254837/osteopontin-attenuates-aging-associated-phenotypes-of-hematopoietic-stem-cells
#18
Novella Guidi, Mehmet Sacma, Ludger Ständker, Karin Soller, Gina Marka, Karina Eiwen, Johannes M Weiss, Frank Kirchhoff, Tanja Weil, Jose A Cancelas, Maria Carolina Florian, Hartmut Geiger
Upon aging, hematopoietic stem cells (HSCs) undergo changes in function and structure, including skewing to myeloid lineages, lower reconstitution potential and loss of protein polarity. While stem cell intrinsic mechanisms are known to contribute to HSC aging, little is known on whether age-related changes in the bone marrow niche regulate HSC aging. Upon aging, the expression of osteopontin (OPN) in the murine bone marrow stroma is reduced. Exposure of young HSCs to an OPN knockout niche results in a decrease in engraftment, an increase in long-term HSC frequency and loss of stem cell polarity...
March 2, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28249776/lack-of-interaction-between-between-nemo-and-sharpin-impairs-linear-ubiquitination-and-nf-%C3%AE%C2%BAb-activation-and-leads-to-incontinentia-pigmenti
#19
E Bal, E Laplantine, Y Hamel, V Dubosclard, B Boisson, A Pesacatore, C Picard, S Hadj-Rabia, G Royer, J Steffann, J P Bonnefont, V M Ursini, P Vabres, A Munnich, J L Casanova, C Bodemer, R Weil, F Agou, A Smahi
BACKGROUND: Incontinentia pigmenti (IP; MIM308300) is a severe, male-lethal, X-linked, dominant genodermatosis resulting from loss-of-function mutations in the IKBKG gene encoding NF-κB essential modulator (NEMO, the regulatory subunit of the IKK complex). In 80% of cases of IP, the deletion of exons 4 to 10 leads to the absence of NEMO and total inhibition of NF-κB signaling. Here, we described a new IKBKG mutation responsible for IP resulting in an inactive truncated form of NEMO...
February 26, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28248564/patient-and-therapist-perspectives-during-the-psychotherapy-termination-process-the-role-of-participation-and-exploration
#20
Margot P Weil, Michael Katz, Mark J Hilsenroth
OBJECTIVE: This study was the first to examine psychotherapy termination from both therapists' and patients' perspectives by using standardized psychotherapy process measures. Our aim was to examine whether patient participation and therapist exploration during the termination phase of treatment are related to how good and productive the session was. METHOD: The sample consisted of 30 outpatient adults who had completed the Vanderbilt Psychotherapy Process Scale-Short form (VPPS-S; Smith, Hilsenroth, Baity, & Knowles, 2003) and the Session Evaluation Questionnaire (SEQ; Stiles, 1980) during a termination-phase session...
2017: Psychodynamic Psychiatry
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