keyword
https://read.qxmd.com/read/38528160/diagnostic-and-prognostic-significance-of-mir-486-5p-in-patients-who-underwent-minimally-invasive-surgery-for-lumbar-spinal-stenosis
#1
JOURNAL ARTICLE
Heqing Zhang, Dong Liu, Xiaoguang Fan
BACKGROUND: This study aimed to investigate the expression and clinical value of microRNA miR-486-5p in diagnosing lumbar spinal stenosis (LSS) patients and predicting the clinical outcomes after minimally invasive spinal surgery (MISS) in LSS patients, and the correlation of miR-486-5p with inflammatory responses in LSS patients. METHODS: This study included 52 LSS patients, 46 patients with lumbar intervertebral disk herniation (LDH) and 42 healthy controls. Reverse transcription quantitative PCR was used to detect miR-486-5p expression...
March 25, 2024: European Spine Journal
https://read.qxmd.com/read/38268042/mechanism-exploration-of-osteoking-in-the-treatment-of-lumbar-disc-herniation-based-on-network-pharmacology-and-molecular-docking
#2
JOURNAL ARTICLE
Xinlei Luo, Jingjing Liu, Xiaoxi Wang, Qiaojun Chen, Yanfa Lei, Zewei He, Xiaowei Wang, Yan Ye, Qiang Na, Changtao Lao, Zhengchang Yang, Jun Jiang
OBJECTIVE: Lumbar disc herniation (LDH) is a common spinal surgical disease. Low back and leg pain caused by LDH is the main factor leading to functional disability, which has caused a serious burden to patients and society. Osteoking can delay the progression of osteoporosis and osteoarthritis, and even has a significant effect on the prevention of deep vein thrombosis after fracture surgery. In recent years, it has been gradually used in the treatment of LDH and has received significant results...
January 24, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38063113/analysis-of-mirna-199-5p-expression-levels-in-serum-samples-of-patients-with-lumbar-disc-degeneration
#3
JOURNAL ARTICLE
Fatma Tuba Akdeniz, Zerrin Barut
Lumbar disc degeneration is a condition caused by damage to the disc due to various causes, which results in disc material coming out of the disc space.  MicroRNAs are small, non-coding RNAs that play a role in the regulation of gene expression by binding to mRNA. MiRNA-199 has previously been studied in the context of intervertebral disc degeneration, and its role in the disease has been reported. The purpose of this study was to look into the role of miRNA 199 in Lumbar Disc Degeneration. This study included 26 patients with Lumbar Disc Degeneration who were admitted to the Neurosurgery Clinic at Yeditepe University Hospital and 26 completely healthy volunteer controls...
November 30, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/37507642/circsntb2-and-cul4a-induces-dysfunction-of-nucleus-pulposus-cells-by-competitively-binding-mir-665
#4
JOURNAL ARTICLE
Yiming Jia, Xin Huo, Leilei Wu, Haibo Zhang, Wenda Xu, Hui Leng
Circular RNA (circRNA) plays important roles in lumbar degenerative diseases. This study aimed to investigate the role of circSNTB2 in regulating the development of lumbar disc herniation (LDH) in vitro and in vivo. The abnormally expressed circSNTB2 in intervertebral disc degeneration (IDD) through bioinformatics analysis was identified, and verified in nucleus pulposus (NP) tissues of patients with LDH. NP cells were treated with TNF-α to mimic the LDH microenvironment. RT-qPCR was applied to determine levels of mRNA and microRNA (miRNA) in clinical samples and cells...
July 28, 2023: Biochemical Genetics
https://read.qxmd.com/read/37298111/microrna-29a-mitigates-laminectomy-induced-spinal-epidural-fibrosis-and-gait-dysregulation-by-repressing-tgf-%C3%AE-1-and-il-6
#5
JOURNAL ARTICLE
I-Ting Lin, Yu-Han Lin, Wei-Shiung Lian, Feng-Sheng Wang, Re-Wen Wu
Spinal epidural fibrosis is one of the typical features attributable to failed back surgery syndrome, with excessive scar development in the dura and nerve roots. The microRNA-29 family (miR-29s) has been found to act as a fibrogenesis-inhibitory factor that reduces fibrotic matrix overproduction in various tissues. However, the mechanistic basis of miRNA-29a underlying the overabundant fibrotic matrix synthesis in spinal epidural scars post-laminectomy remained elusive. This study revealed that miR-29a attenuated lumbar laminectomy-induced fibrogenic activity, and epidural fibrotic matrix formation was significantly lessened in the transgenic mice (miR-29aTg) as compared with wild-type mice (WT)...
May 23, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37046075/microrna-29a-a-novel-target-for-non-operative-management-of-symptomatic-lumbar-spinal-stenosis
#6
JOURNAL ARTICLE
Richard A Wawrose, Anthony A Oyekan, Yunting Melissa Tang, Stephen R Chen, Joseph Chen, Brandon K Couch, Dong Wang, Peter G Alexander, Gwendolyn A Sowa, Nam V Vo, Joon Y Lee
PURPOSE: Lumbar spinal stenosis (LSS) is the most common reason for spinal surgery in patients over the age of 65, and there are few effective non-surgical treatments. Therefore, the development of novel treatment or preventative modalities to decrease overall cost and morbidity associated with LSS is an urgent matter. The cause of LSS is multifactorial; however, a significant contributor is ligamentum flavum hypertrophy (LFH) which causes mechanical compression of the cauda equina or nerve roots...
April 12, 2023: European Spine Journal
https://read.qxmd.com/read/37016437/mechanical-overloading-induced-mir-325-3p-reduction-promoted-chondrocyte-senescence-and-exacerbated-facet-joint-degeneration
#7
JOURNAL ARTICLE
Jinyun Zhao, Chengjun Li, Tian Qin, Yuxin Jin, Rundong He, Yi Sun, Zhide Liu, Tianding Wu, Chunyue Duan, Yong Cao, Jianzhong Hu
OBJECTIVE: Lumbar facet joint (LFJ) degeneration is one of the main causes of low back pain (LBP). Mechanical stress leads to the exacerbation of LFJ degeneration, but the underlying mechanism remains unknown. This study was intended to investigate the mechanism of LFJ degeneration induced by mechanical stress. METHODS: Here, mice primary chondrocytes were used to screen for key microRNAs induced by mechanical overloading. SA-β-gal staining, qRT-PCR, western blot, and histochemical staining were applied to detect chondrocyte senescence in vitro and in vivo...
April 4, 2023: Arthritis Research & Therapy
https://read.qxmd.com/read/37014317/circular-rna-pdk1-targets-mir-4731-5p-to-enhance-tnxb-expression-in-ligamentum-flavum-hypertrophy
#8
JOURNAL ARTICLE
Kai Zhang, Xin Wang, Li-Ting Zeng, Xiao Yang, Xiao-Fei Cheng, Hai-Jun Tian, Chen Chen, Xiao-Jiang Sun, Chang-Qing Zhao, Hui Ma, Jie Zhao
Hypertrophic ligamentum flavum (LF) is a main factor responsible for lumbar spinal stenosis (LSS); however, the exact mechanisms of the pathogenesis of these processes remain unknown. This study aimed to elucidate whether circular RNAs and microRNAs regulate the pathogenesis of LF and LSS, especially focusing on circPDK1 (hsa_circ_0057105), a circRNA targeting pyruvate dehydrogenase kinase 1 and differentially expressed in LF tissues between lumbar disk herniation and LSS patients. The circPDK1/miR-4731 and miR-4731/TNXB (Tenascin XB) interactions were predicted and validated by luciferase reporter assay...
May 2023: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/36781308/comprehensive-analysis-of-microrna-expression-in-lumbar-facet-joint-capsules-and-synovium-of-patients-with-osteoarthritis-comparison-between-early-stage-and-late-stage-osteoarthritis-samples-from-a-single-individual
#9
JOURNAL ARTICLE
Koji Ishida, Shinji Tanishima, Atsushi Tanida, Keita Nagira, Tokumitsu Mihara, Chikako Takeda, Shinya Ogawa, Hideki Nagashima
BACKGROUND: MicroRNA is attracting attention as a therapeutic target for osteoarthritis. We focused on joint capsules and synovium in lumbar facet joint osteoarthritis. The purpose of this study was to identify microRNAs that are upregulated in lumbar facet joint capsules and synovium with osteoarthritis. METHODS: We included patients who underwent spinal fusion for degenerative lumbar spine diseases. We selected patients who had both early-stage and late-stage facet joint osteoarthritis in a single individual...
February 11, 2023: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://read.qxmd.com/read/36558990/segmental-upregulation-of-asic1-channels-in-the-formalin-acute-pain-mouse-model
#10
JOURNAL ARTICLE
María Natalia Gobetto, Libia Catalina Salinas Castellanos, Natalia Estefanía Contreras, Alejandro Omar Sodero, Damián Alejandro Cambiagno, Georgina Oriana Mingolo Malnati, Mayra Micaela Montes, Osvaldo Daniel Uchitel, Carina Weissmann
BACKGROUND: Hindpaw injection of formalin in rodents is used to assess acute persistent pain. The response to formalin is biphasic. The initial response (first minutes) is thought to be linked to inflammatory, peripheral mechanisms, while the latter (around 30 min after the injection), is linked to central mechanisms. This model is useful to analyze the effect of drugs at one or both phases, and the involvement of ion channels in the response. Acid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in pain conditions...
December 12, 2022: Pharmaceuticals
https://read.qxmd.com/read/36474943/association-of-presurgical-circulating-micrornas-with-1-year-postsurgical-pain-reduction-in-spine-facet-osteoarthritis-patients-with-lumbar-spinal-stenosis
#11
JOURNAL ARTICLE
Starlee Lively, Marie Milliot, Pratibha Potla, Osvaldo Espin-Garcia, Mehdi Layeghifard, Kala Sundararajan, Helal Endisha, Akihiro Nakamura, Anthony V Perruccio, Christian Veillette, Mohit Kapoor, Y Raja Rampersaud
PURPOSE: Up to 30% of spine facet osteoarthritis patients with lumbar spinal stenosis (SF-OA ​+ ​LSS) have little to no improvement in their pain after surgery. Lack of meaningful improvement in pain following surgery provides a unique opportunity to identify specific predictive biomarker signatures that might be associated with the outcomes of surgical treatment. The objective of the present study was to determine whether a microRNA (miRNA) biomarker signature could be identified in presurgical blood plasma that corresponded with levels of SF-OA ​+ ​LSS patient post-surgical pain intensity one year later...
September 2022: Osteoarthritis and cartilage open
https://read.qxmd.com/read/36440217/circulating-microrna-responses-to-acute-whole-body-vibration-and-resistance-exercise-in-postmenopausal-women
#12
JOURNAL ARTICLE
Samuel R Buchanan, Ryan M Miller, Michelle Nguyen, Christopher D Black, J Mikhail Kellawan, Michael G Bemben, Debra A Bemben
Evaluating alterations in circulating microRNA (c-miRNA) expression may provide deeper insight into the role of exercise in the attenuation of the negative effects of aging on musculoskeletal health. Currently, there are sparse data on c-miRNA responses to acute exercise in postmenopausal women. The purpose of this study was to characterize the effects of acute bouts of resistance exercise and whole-body vibration on expression of selected c-miRNAs in postmenopausal women aged 65-76 years (n=10). We also examined relationships between c-miRNAs and muscle strength and bone characteristics...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/36430472/identification-of-epigenetic-interactions-between-microrna-30c-5p-and-dna-methyltransferases-in-neuropathic-pain
#13
JOURNAL ARTICLE
Raquel Francés, Jorge Mata-Garrido, Roberto de la Fuente, María Carcelén, Miguel Lafarga, María Teresa Berciano, Raquel García, María A Hurlé, Mónica Tramullas
Neuropathic pain is a prevalent and severe chronic syndrome, often refractory to treatment, whose development and maintenance may involve epigenetic mechanisms. We previously demonstrated a causal relationship between miR-30c-5p upregulation in nociception-related neural structures and neuropathic pain in rats subjected to sciatic nerve injury. Furthermore, a short course of an miR-30c-5p inhibitor administered into the cisterna magna exerts long-lasting antiallodynic effects via a TGF-β1-mediated mechanism...
November 13, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36428932/bone-metabolism-related-serum-micrornas-to-diagnose-osteoporosis-in-middle-aged-and-elderly-women
#14
JOURNAL ARTICLE
Sheng-Li Zhao, Zhen-Xing Wen, Xiao-Yi Mo, Xiao-Yan Zhang, Hao-Nan Li, Wing-Hoi Cheung, Dan Fu, Shi-Hong Zhang, Yong Wan, Bai-Ling Chen
Objective : Postmenopausal osteoporosis (PMOP), a chronic systemic metabolic disease prevalent in middle-aged and elderly women, heavily relies on bone mineral density (BMD) measurement as the diagnostic indicator. In this study, we investigated serum microRNAs (miRNAs) as a possible screening tool for PMOP. Methods : This investigation recruited 83 eligible participants from 795 community-dwelling postmenopausal women between June 2020 and August 2021. The miRNA expression profiles in the serum of PMOP patients were evaluated via miRNA microarray (six PMOP patients and four postmenopausal women without osteoporosis (n-PMOP) as controls)...
November 19, 2022: Diagnostics
https://read.qxmd.com/read/36408612/circulating-mirnas-respond-to-denosumab-treatment-after-two-years-in-postmenopausal-women-with-osteoporosis
#15
JOURNAL ARTICLE
Zora Messner, David Carro-Vazquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
CONTEXT: MicroRNAs (miRNAs) are short, single-stranded, non-coding RNAs which regulate gene expression. They originate from various tissues including bone and regulate different biological mechanisms including bone metabolism. OBJECTIVE: The aim of this project was to investigate circulating miRNAs as promising biomarkers for treatment monitoring in women with postmenopausal osteoporosis on denosumab (DMAB) therapy. DESIGN, SETTING AND PATIENTS: In this prospective, observational, single-centre study twenty-one postmenopausal women treated with DMAB were included for a longitudinal follow-up of two years...
November 19, 2022: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/36143385/upregulation-of-spinal-mir-155-5p-contributes-to-mechanical-hyperalgesia-by-promoting-inflammatory-activation-of-microglia-in-bone-cancer-pain-rats
#16
JOURNAL ARTICLE
Yanping Jian, Zongbin Song, Zhuofeng Ding, Jian Wang, Ruike Wang, Xinran Hou
Bone cancer pain (BCP) seriously deteriorates the life quality of patients, but its underlying mechanism is still unclear. Spinal microRNAs might contribute to the development of BCP and the role of microglial activation is controversial. In this study, we established a BCP model by injecting Walker 256 breast carcinoma cells into the tibial intramedullary cavity of rats and significant hyperalgesia was observed in the BCP rats. The lumbar spinal cords were harvested to perform RNA sequencing (RNA-seq), and 31 differentially expressed miRNAs (26 upregulated and 5 downregulated) were identified in the BCP rats...
August 30, 2022: Life
https://read.qxmd.com/read/36045396/transcriptome-profiling-of-micrornas-reveals-potential-mechanisms-of-manual-therapy-alleviating-neuropathic-pain-through-microrna-547-3p-mediated-map4k4-nf-%C3%AE%C2%BAb-signaling-pathway
#17
JOURNAL ARTICLE
Chongjie Yao, Jun Ren, Ruixin Huang, Cheng Tang, Yanbin Cheng, Zhizhen Lv, Lingjun Kong, Sitong Fang, Jiming Tao, Yangyang Fu, Qingguang Zhu, Min Fang
BACKGROUND: Local neuroinflammation secondary to spinal nerve compression in lumbar disk herniation (LDH) is a key driver contributing to neuropathic pain. Manual therapy (MT), a widely used nonsurgical therapy, can relieve LDH-mediated pain by reducing inflammation. MT has attracted extensive attention; however, its mechanism remains poorly understood. MicroRNAs (miRNAs) are important regulators of pain signaling transduction, but are rarely reported in the chronic compression of dorsal root ganglia (CCD) model, and further investigation is needed to decipher whether they mediate anti-inflammatory and analgesic effects of MT...
September 1, 2022: Journal of Neuroinflammation
https://read.qxmd.com/read/35984761/mechanism-of-mir-25-3p-carried-by-extracellular-vesicles-derived-from-platelet-rich-plasma-in-il-1%C3%AE-induced-nucleus-pulposus-cell-degeneration-via-the-sox4-cxcr7-axis
#18
JOURNAL ARTICLE
Baoshan Hu, Lianxin Wang, Naikun Sun, Shengrong Lin, Gang Rui
Objectives: Nucleus pulposus (NP) cell degeneration promotes the progression of intervertebral disc (IVD) degeneration. MicroRNAs (miRs) are associated with IVD degeneration. This study expounded the mechanism of microRNA (miR)-25-3p carried by extracellular vesicles (EVs) derived from platelet-rich plasma (PRP) in interleukin (IL)-1β-induced NP cell degeneration. Methods: Platelet-rich plasma from mouse blood was obtained, and EVs were isolated from PRP (EVs derived from PRP [PRP-EVs]) and identified. Nucleus pulposus cells were isolated from the mouse lumbar IVD and treated with IL-1β to induce NP cell degeneration...
July 1, 2022: Shock
https://read.qxmd.com/read/35634507/menopausal-transition-prospective-study-of-estrogen-status-circulating-micrornas-and-biomarkers-of-bone-metabolism
#19
JOURNAL ARTICLE
Jiri Baloun, Aneta Pekacova, Laszlo Wenchich, Hana Hruskova, Ladislav Senolt, Xiao Svec, Karel Pavelka, Jan J Stepan
Objective: Osteoporosis is associated with an impaired balance between bone resorption and formation, which in turn leads to bone loss and fractures. Many recent studies have underlined the regulatory role of microRNAs (miRNAs) in bone remodeling processes and their potential as biomarkers of osteoporosis. The purpose of this study was to prospectively examine the association of circulating miRNAs and bone biomarkers with estrogen status in women before and after oophorectomy, as well as in oophorectomized women on estrogen therapy...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/35594783/motion-sickness-decreases-low-back-function-and-changes-gene-expression-in-military-aircrew
#20
JOURNAL ARTICLE
Jonathan S Dufour, Ali Reiter, Cyndy Cox, Eric B Weston, Michael Markey, Ashley Turner, Peter Le, Alexander M Aurand, Stacy Simmons, Lorenna Altman, Prasath Mageswaran, Kermit Davis, Dustin Huber, Amit Bhattacharya, William S Marras
BACKGROUND: Motion sickness and low back disorders are prevalent and debilitating conditions that affect the health, performance, and operational effectiveness of military aircrews. This study explored the effects of a motion sickness stimulus on biomechanical and genetic factors that could potentially be involved in the causal pathways for both disorders. METHODS: Subjects recruited from a military population were exposed to either a mild (n = 12) or aggressive (n = 16) motion sickness stimulus in a Neuro-Otologic Test Center...
June 2022: Clinical Biomechanics
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