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https://www.readbyqxmd.com/read/29162993/a-61-year-old-man-with-cystoid-macular-edema-and-chorioretinal-folds-after-cataract-surgery
#1
Andrew Lee, Sandra R Montezuma
No abstract text is available yet for this article.
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/29158262/the-epac-rap1-pathway-prevents-and-reverses-cytokine-induced-retinal-vascular-permeability
#2
Carla J Ramos, Chengmao Lin, Xuwen Liu, David A Antonetti
Increased retinal vascular permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as diabetic retinopathy, age-related macular degeneration, and central retinal vein occlusions. Pathological changes in vascular permeability are driven by growth factors such as VEGF and by pro-inflammatory cytokines such as TNF-α. Identifying the pro-barrier mechanisms that block vascular permeability and restore the blood-retinal barrier (BRB) may lead to new therapies. The cAMP-dependent guanine nucleotide exchange factor EPAC promotes exchange of GTP in the small GTPase Rap1...
November 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29157443/a-benchmark-study-of-automated-intra-retinal-cyst-segmentation-algorithms-using-optical-coherence-tomography-b-scans
#3
G N Girish, V A Anima, Abhishek R Kothari, P V Sudeep, Sohini Roychowdhury, Jeny Rajan
(BACKGROUND AND OBJECTIVES): Retinal cysts are formed by accumulation of fluid in the retina caused by leakages from inflammation or vitreous fractures. Analysis of the retinal cystic spaces holds significance in detection and treatment of several ocular diseases like age-related macular degeneration, diabetic macular edema etc. Thus, segmentation of intra-retinal cysts and quantification of cystic spaces are vital for retinal pathology and severity detection. In the recent years, automated segmentation of intra-retinal cysts using optical coherence tomography B-scans has gained significant importance in the field of retinal image analysis...
January 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29157128/twenty-four-months-follow-up-of-intravitreal-bevacizumab-injection-versus-intravitreal-triamcinolone-acetonide-injection-for-the-management-of-persistent-non-infectious-uveitic-cystoid-macular-edema
#4
Andrés F Lasave, Ariel Schlaen, David G Zeballos, Manuel Díaz-Llopis, Cristóbal Couto, Wael M El-Haig, J Fernando Arevalo
PURPOSE: To report the efficacy of intravitreal bevacizumab (IVB) injection versus intravitreal triamcinolone acetonide (IVT) for persistent non-infectious uveitic cystoid macular edema (CME). METHODS: Interventional retrospective comparative case series evaluated 37 consecutive patients (44 eyes) with completely controlled uveitis and recalcitrant CME. Patients received repeated injections of 1.25 mg of IVB or 4 mg of IVT. RESULTS: Best-corrected visual acuity (BCVA) at baseline and 24 months was logMAR 1 and 0...
November 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29155696/safety-of-consecutive-same-day-bilateral-intravitreal-dexamethasone-implant-ozurdex
#5
Kapil G Kapoor, James B Colchao
PURPOSE: The objective of this study was to evaluate patient safety and tolerance of consecutive bilateral intravitreal dexamethasone (Ozurdex) injections during a single visit for the treatment of cystoid macular edema secondary to retinal vein occlusion, diabetic macular edema, or noninfectious posterior uveitis. METHODS: This was a retrospective single-center institutional review board-approved study from March 1, 2013, through August 1, 2016. All patients had a complete ophthalmologic examination and optical coherence tomography imaging...
November 16, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29145552/association-between-perceived-barriers-to-diabetes-self-management-and-diabetic-retinopathy-in-asian-patients-with-type-2-diabetes
#6
Ryan Eyn Kidd Man, Eva K Fenwick, Alfred Tau Liang Gan, Charumathi Sabanayagam, Preeti Gupta, Amudha Aravindhan, Tien Yin Wong, Gavin Siew Wei Tan, Ecosse L Lamoureux
Importance: A patient's perceived barriers to diabetes self-management (DSM) may affect his or her risk of diabetic retinopathy (DR); however, few studies have examined this association. Objective: To examine the association between perceived barriers to DSM and the severity spectrum of DR in Asian patients with type 2 diabetes. Design, Setting, and Participants: A cross-sectional clinic-based study, the Singapore Diabetes Management Project, was conducted from December 28, 2010, to March 20, 2013, at the Singapore National Eye Centre, a tertiary eye care institute...
November 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29144826/cataract-surgery-in-patients-with-diabetes-management-strategies
#7
Scott R Peterson, Paolo A Silva, Timothy J Murtha, Jennifer K Sun
Diabetes is a chronic systemic disease that affects nearly one in eight adults worldwide. Ocular complications, such as cataract, can lead to significant visual impairment. Among the worldwide population, cataract is the leading cause of blindness, and patients with diabetes have an increased incidence of cataracts which mature earlier compared to the rest of the population. Cataract surgery is a common and safe procedure, but can be associated with vision-threatening complications in the diabetic population, such as diabetic macular edema, postoperative macular edema, diabetic retinopathy progression, and posterior capsular opacification...
November 16, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29143927/update-on-the-treatment-of-uveitis-in-patients-with-juvenile-idiopathic-arthritis-a-review
#8
REVIEW
Ioannis Asproudis, Andreas Katsanos, Nikolaos Kozeis, Alexandra Tantou, Anastasios G Konstas
Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until ocular complications arise. The risk of uveitis is increased in girls with an early onset of oligoarthritis and positive antinuclear antibodies. Even though the inflammation in patients with juvenile idiopathic arthritis is initially limited in the anterior part of the eye, chronic active inflammation may eventually cause significant damage to the posterior pole...
November 16, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/29142567/outcomes-of-intravitreal-bevacizumab-and-macular-photocoagulation-for-treatment-of-diabetic-macular-edema-in-a-tertiary-care-eye-hospital-karachi
#9
Adil Salim Jafri, Aziz-Ur-Rehman, Abdul Haleem Mirani, Saleh Memon
Objective: To study the outcomes of intravitreal injection of Bevacizumab and laser photocoagulation in the treatment of diabetic macular edema (DME). Methods: Seventy-two eyes of 59 patients with diabetic macular edema were divided into two groups of 41 eyes (Group-A) and 31 eyes (Group-B). Subjects in group-A were treated with three intravitreal injections of Bevacizumab (IVB), and that of group-B with macular photocoagulation. Duration of study was 9 months. Follow up pattern for both groups was1, 2, 3 and 6 months...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29138701/valsalva-related-subretinal-hemorrhage-as-a-presenting-symptom-of-polypoidal-choroidal-vasculopathy
#10
Yousif Subhi, Torben L Sørensen
Purpose: To describe a case of Valsalva-related subretinal hemorrhage as a presenting symptom of polypoidal choroidal vasculopathy (PCV). The patient refrained from treatment against our best advice, and thus this is also a rare case of the natural course of an untreated PCV. Methods: Case report. Results: A 66-year-old female with a respiratory infection coughed intensely until exhaustion, after which she developed visual symptoms on the right eye...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29137019/optical-coherence-tomography-angiography-in-patients-with-diabetic-retinopathy-treated-with-anti-vegf-intravitreal-injections-case-report
#11
Katarzyna Michalska-Małecka, Anna Heinke Knudsen
PURPOSE: To present optical coherence tomography angiography (OCTA) features in patients with diabetic retinopathy (DR) at the baseline and in response to treatment with anti-VEGF intravitreal injections. To investigate the role of OCTA in management of patients with DR. METHODS: Retrospective case series showing primary outcomes of 3 patients with DR and diabetic macular edema. Patients were injected intravitreally a loading phase of 3 monthly 2.0 mg aflibercept, followed by 2 injections bimonthly (5 injections in total)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135802/panretinal-photocoagulation-versus-ranibizumab-for-proliferative-diabetic-retinopathy-comparison-of-peripapillary-retinal-nerve-fiber-layer-thickness-in-a-randomized-clinical-trial
#12
Lee M Jampol, Isoken Odia, Adam R Glassman, Carl W Baker, Anjali M Bhorade, Dennis P Han, Glenn J Jaffe, Michele Melia, Neil M Bressler, Angelo P Tanna
PURPOSE: Compare changes in retinal nerve fiber layer (RNFL) thickness between eyes assigned to intravitreous ranibizumab or panretinal photocoagulation and assess correlations between changes in RNFL and visual field sensitivity and central subfield thickness. METHODS: Eyes with proliferative diabetic retinopathy were randomly assigned to ranibizumab or panretinal photocoagulation. Baseline and annual follow-up spectral domain optical coherence tomography RNFL imaging, optical coherence tomography macular imaging, and automated static perimetry (Humphrey visual field 60-4 algorithm) were performed...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29135799/peripapillary-pachychoroid-syndrome
#13
Nopasak Phasukkijwatana, K Bailey Freund, Rosa Dolz-Marco, Mayss Al-Sheikh, Pearse A Keane, Catherine A Egan, Sandeep Randhawa, Jay M Stewart, Qingyun Liu, Alex P Hunyor, Allan Kreiger, Aaron Nagiel, Robert Lalane, Mansour Rahimi, Won Ki Lee, Lee Merrill Jampol, David Sarraf
PURPOSE: To describe the features of peripapillary pachychoroid syndrome (PPS), a novel pachychoroid disease spectrum (PDS) entity. METHODS: Medical records of 31 eyes (16 patients) with choroidal thickening associated with intraretinal and/or subretinal fluid in the nasal macula extending from the disk were reviewed (patients with PPS). Choroidal thickness was compared with 2 age-matched cohorts: typical PDS (17 eyes with central serous chorioretinopathy or pachychoroid neovasculopathy) and 19 normal eyes...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29134182/high-dose-2-5-mg-intravitreal-bevacizumab-as-rescue-therapy-for-persistent-postradiation-cystoid-macular-edema
#14
Mohammed Ali Khan, Arman Mashayekhi, Kyle Ferguson, Jerry A Shields, Carol L Shields
Background/Aims: To investigate the efficacy of intravitreal high-dose (2.5 mg/0.1 mL) bevacizumab as rescue therapy for postradiation cystoid macular edema (CME) resistant to standard-dose (1.25 mg/0.05 mL) bevacizumab. Methods: Retrospective, interventional case series. Results: Fifteen eyes of 15 patients were included. Eyes were treated with a mean of 10 standard-dose (1.25 mg) bevacizumab injections but failed to show CME resolution. Following 3 monthly treatments of high-dose (2...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29132693/relationship-between-visual-outcomes-and-retinal-fluid-resorption-in-patients-with-diabetic-macular-edema-treated-with-ranibizumab
#15
B Penaud, F Fajnkuchen, O Levy, G Chaine, A Giocanti-Auregan
PURPOSE: We assessed the relationship between visual acuity (VA) recovery and a qualitative criterion - complete retinal fluid resorption (CRFR) - among patients treated with ranibizumab for diabetic macular edema (DME) METHODS: All consecutive diabetic patients with central DME received a loading dose of 3 monthly injections of ranibizumab 0.5mg, followed by retreatments on an as-needed basis as determined by monthly follow-up. Patients were divided into 3 groups: CRFR (defined as a CRT <300μm and restoration of the foveolar pit) with BCVA≤70 letters (group 1: G1), CRFR with BCVA>70 letters (20/40) (G2), and persistent retinal fluid throughout the follow-up (G3)...
November 10, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29132691/-practical-assessment-of-dsaek-in-the-management-of-endothelial-decompensation-following-penetrating-keratoplasty
#16
E Neiter, C Goetz, F Tortuyaux, A Ehrhardt, N Houmad, J-M Perone
PURPOSE: To report our anatomical and functional results as well as possible complications of the first six Descemet's stripping endothelial keratoplasties (DSAEK) performed in our department for endothelial decompensation after penetrating keratoplasty (PK) METHODS: This was a retrospective and observational monocentric study of six patients with DSAEK after prior PK between January 2015 and July 2016. The data collected were: demographic characteristics (age, sex), ophthalmological comorbidities, initial indication for PK, delay between PK and DSAEK...
November 11, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29127949/effect-of-adding-dexamethasone-to-continued-ranibizumab-treatment-in-patients-with-persistent-diabetic-macular-edema-a-drcr-network-phase-2-randomized-clinical-trial
#17
Raj K Maturi, Adam R Glassman, Danni Liu, Roy W Beck, Abdhish R Bhavsar, Neil M Bressler, Lee M Jampol, Michele Melia, Omar S Punjabi, Hani Salehi-Had, Jennifer K Sun
Importance: Some eyes have persistent diabetic macular edema (DME) following anti-vascular endothelial growth factor (anti-VEGF) therapy for DME. Subsequently adding intravitreous corticosteroids to the treatment regimen might result in better outcomes than continued anti-VEGF therapy alone. Objective: To compare continued intravitreous ranibizumab alone with ranibizumab plus intravitreous dexamethasone implant in eyes with persistent DME. Design, Setting, and Participants: Phase 2 multicenter randomized clinical trial conducted at 40 US sites in 129 eyes from 116 adults with diabetes between February 2014 and December 2016...
November 11, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29127657/real-world-cost-savings-demonstrated-by-switching-patients-with-refractory-diabetic-macular-edema-to-intravitreal-fluocinolone-acetonide-iluvien-a-retrospective-cost-analysis-study
#18
Soon W Ch'ng, Alexander J Brent, Theodoros Empeslidis, Vasileios Konidaris, Somnath Banerjee
INTRODUCTION: It is hypothesized that using fluocinolone acetonide (FAc) implants such as Iluvien for the treatment of diabetic macular edema (DME) may reduce the total number of intravitreal injections and clinic visits, resulting in an overall treatment cost reduction. The primary aim of this study is to identify the real-world cost savings achievable in a tertiary National Health Service (NHS) hospital. METHODS: A retrospective cost analysis study was conducted...
November 10, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29126927/mechanisms-of-macular-edema-beyond-the-surface
#19
REVIEW
Alejandra Daruich, Alexandre Matet, Alexandre Moulin, Laura Kowalczuk, Michaël Nicolas, Alexandre Sellam, Pierre-Raphaël Rothschild, Samy Omri, Emmanuelle Gélizé, Laurent Jonet, Kimberley Delaunay, Yvonne De Kozak, Marianne Berdugo, Min Zhao, Patricia Crisanti, Francine Behar-Cohen
Macular edema consists of intra- or subretinal fluid accumulation in the macular region. It occurs during the course of numerous retinal disorders and can cause severe impairment of central vision. Major causes of macular edema include diabetes, branch and central retinal vein occlusion, choroidal neovascularization, posterior uveitis, postoperative inflammation and central serous chorioretinopathy. The healthy retina is maintained in a relatively dehydrated, transparent state compatible with optimal light transmission by multiple active and passive systems...
November 7, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29121367/idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-syndrome-presenting-with-branch-retinal-artery-occlusion
#20
Jennifer A Zacharia, Adam T Chin, Carl B Rebhun, Ricardo N Louzada, Mehreen Adhi, Emily D Cole, Carlos Moreira-Neto, Nadia K Waheed, Jay S Duker
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) is a rare syndrome affecting the retinal and optic disc vasculature. Diffuse retinal ischemia, macular edema, and neovascularization may lead to bilateral vision loss. The authors report a case of a 36-year-old woman presenting with branch retinal artery occlusion (BRAO) in her right eye who was subsequently diagnosed with IRVAN syndrome. She was treated with panretinal photocoagulation for peripheral retinal ischemia and pars plana vitrectomy for vitreous hemorrhage...
November 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
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