keyword
https://read.qxmd.com/read/38547157/uveitic-macular-edema-clinical-outcomes-in-real-world-practice
#1
JOURNAL ARTICLE
Nazima Ali, Joanne Sims, Rachael Niederer
PURPOSE: To examine the real-world management and outcomes of uveitic cystoid macular oedema (CME). DESIGN: Retrospective study. METHODS: Patients with uveitic CME were identified from the Inflammatory Eye Disease database. 248 eyes of 218 patients with uveitic CME were identified. Main Outcome Measures : Time to resolution, time to recurrence and vision loss. RESULTS: Median age at time of CME was 51.7 years [IQR 37...
March 28, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38546424/multiple-sclerosis-associated-uveitis-a-case-report-of-refractory-bilateral-chronic-granulomatous-panuveitis-successfully-treated-with-tocilizumab
#2
JOURNAL ARTICLE
William Gil, Hassan Lagrib, Louis Olagne, Céline Tilignac, Maud Perie, Frédéric Taithe, Xavier Moisset, Frederic Chiambaretta, Pierre Clavelou, Marc Andre, Ludovic Trefond
PURPOSE: To report a case of uveitis associated with multiple sclerosis (MS) that was refractory to multiple lines of therapy but achieved remission with tocilizumab. METHODS: We conducted a retrospective analysis of the patient's medical record including clinical, biological and imaging data. RESULTS: A 33-year-old female patient with a history of MS inactive for 5 years on teriflunomide, and no significant medical or ophthalmological history, presented with bilateral granulomatous panuveitis...
March 28, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38545732/new-onset-of-uveitis-during-infliximab-treatment-a-case-report
#3
JOURNAL ARTICLE
Mejda Bouladi, Amal Ben Othmen, Miladi Sawssen, Merieme Kalou, Ahmed Laater, Lamia El Fekih
INTRODUCTION: Anti-tumor necrosis factor α (anti-TNF α) agents are an effective treatment for a variety of inflammatory and autoimmune diseases. In ophthalmology anti-TNF α began to emerge as a possible therapy for non-infectious uveitis, paradoxically their administration may result in the onset or recurrence of inflammatory eye disease such as uveitis. We reported a case of new onset of bilateral anterior and intermediate uveitis in a patient with rheumatoid arthritis (RA) while being treated with infliximab and we performed a review of literature...
January 5, 2024: La Tunisie Médicale
https://read.qxmd.com/read/38542043/real-world-experience-with-brolucizumab-compared-to-aflibercept-in-treatment-na%C3%A3-ve-and-therapy-refractory-patients-with-diabetic-macular-edema
#4
JOURNAL ARTICLE
Anne Rübsam, Leopold Hössl, Saskia Rau, Alexander Böker, Oliver Zeitz, Antonia M Joussen
Background : To report on the outcome of intravitreal brolucizumab compared to aflibercept in patients with diabetic macular edema (DME). Methods : Prospective, observational, study in 35 eyes of 24 patients with a loading dose of five injections of 6 mg brolucizumab every 6 weeks (q6w, treatment-naïve eyes) or a minimum of two injections of brolucizumab q6w after the switch (recalcitrant DME eyes), followed by a treat and extend (T&E) regimen. The results were compared with 40 eyes of 31 DME patients who were treated with aflibercept...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541760/sustained-disease-control-in-dme-patients-upon-treatment-cessation-with-brolucizumab
#5
JOURNAL ARTICLE
Justus G Garweg, Sonja Steinhauer
Background: Treatment cessation due to a dry retina has not been systematically addressed in diabetic macular edema (DME). In three out of four patients receiving 6 mg of brolucizumab in the KITE study, treatment was terminated after the study ended. Methods: The KITE study was a double-masked, multicenter, active-controlled, randomized trial (NCT03481660) in DME patients. Per protocol, patients received five loading injections of Brolucizumab at 6-week intervals, with the option to adjust to 8 weeks in case of disease activity or to extend in the second year to a maximum of 16 weeks in the absence of retinal fluid...
March 7, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38540987/efficacity-and-safety-of-the-fluocinolone-acetonide-implant-in-uveitic-macular-edema-a-real-life-study-from-the-french-uveitis-network
#6
JOURNAL ARTICLE
Matthieu Jabbour, Laurent Kodjikian, Alexandre Bourdin, Marie-Bénédicte Rougier, Yasmine Serrar, Michel Weber, Hélène Massé, Driss Mazhar, Sara Perez-Roustit, Christophe Chiquet, Marie Nöelle Delyfer, Bahram Bodaghi, Sara Touhami
PURPOSE: To evaluate the safety and efficacy of the fluocinolone acetonide implant (FAi, Iluvien® Horus pharma, Nice, France) in non-infectious uveitic macular edema (UME) and to approach the predictive factors of treatment response. METHODS: This retrospective, multicenter real-life study included patients with chronic non-infectious UME who received intravitreal FAi after at least two dexamethasone implants (DEXi). RESULTS: Twenty-six eyes from 22 patients (73...
February 24, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38538293/effect-of-intravitreal-aflibercept-on-corneal-endothelial-cells
#7
JOURNAL ARTICLE
Zuzana Šulavíková, Zuzana Šustykevičová, Marek Káčerik, Vladimír Krásnik
AIM:  To determine the effect of repeated intravitreal injections of aflibercept on the corneal endothelium in patients with diabetic macular edema (DME) and macular edema due to retinal vein occlusion (RVO). METHODS:  In a prospective study conducted between January 2021 and November 2023, a total of 87 treatment-naive eyes with DME and RVO were evaluated. The exclusion criteria were surgery or laser intervention during the follow-up period, contact lens wear, cataract surgery in the last 6 months, dystrophy, or other corneal condition that may cause endothelial damage...
2024: Ceská a Slovenská Oftalmologie
https://read.qxmd.com/read/38536978/bilateral-retinal-venous-occlusion-in-atypical-hemolytic-uremic-syndrome-due-to-complement-factor-h-mutation
#8
JOURNAL ARTICLE
Saban Gonul, Serhat Eker
PURPOSE: Atypical hemolytic uremic syndrome (aHUS) is a rare progressive thrombotic microangiopathy caused by overactivation in the alternative complement pathway. A wide spectrum of environmental triggers, such as viruses, vaccination, drugs, pregnancy, neoplasms, transplant, and autoimmune diseases can cause aHUS in genetically susceptible individuals. In this report, the diagnosis and treatment process of aHUS and bilateral retinal venous occlusion (RVO) will be presented. METHODS: Single-case, retrospective management of ophthalmological and systemic manifestations...
March 27, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38534040/characterization-of-the-visually-impaired-patients-with-diabetes-mellitus-in-japan
#9
JOURNAL ARTICLE
Yuka Sugihara, Yoshihiro Takamura, Yutaka Yamada, Masakazu Morioka, Makoto Gozawa, Kumiko Kato, Takao Hirano, Fumiko Murao, Miho Shimizu, Sentaro Kusuhara, Tomoya Murakami, Yuki Takenaka, Naoko Okabe, Tatsuya Jujo, Hiroto Terasaki, Daisuke Nagasato, Zhenyu Dong, Shigeo Yoshida, Shuntaro Ogura, Kanako Yasuda, Gaku Ishigooka, Osamu Sawada, Fumiaki Higashijima, Masaru Inatani
AIMS/INTRODUCTION: To conduct a multicenter survey of visually impaired patients with diabetes mellitus (DM) and to identify the physical and ocular characteristics that lead to blindness in Japan. MATERIALS AND METHODS: Visually impaired patients with diabetes mellitus in Japan were divided into blind and low-vision groups according to the World Health Organization classification. Data on parameters related to diabetes mellitus and ocular complications in the right and left eyes were collected from 19 highly advanced medical facilities and compared between the two groups...
March 27, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38532849/multimodal-imaging-in-a-case-of-presumed-secondary-vitreoretinal-lymphoma-presenting-with-inner-retina-and-optic-nerve-head-infiltration
#10
Emily S Levine, Nikhil N Batra
PURPOSE: To report the findings supported by multimodal imaging in a case of secondary vitreoretinal lymphoma presenting with inner retina and optic nerve head infiltration. OBSERVATIONS: A 64-year-old man with systemic diffuse large B-cell lymphoma presented with reduced visual acuity. Moderate anterior chamber and vitreous cell were present. Fundus exam showed bilateral disc edema and diffuse opaque macular infiltrates with a pseudo cherry-red spot in the left eye...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38531022/case-report-macula-structural-and-functional-assessment-in-nab-paclitaxel-related-cystoid-macular-edema
#11
JOURNAL ARTICLE
Lawrence Kwok, Alina Mahmood, Sanjeev Kumar, Andrew Chang
Nab-paclitaxel-related cystoid macular edema is a rare ophthalmic adverse drug reaction. We present a 54-year-old woman with metastatic hormone receptor positive, HER-2 negative breast carcinoma who developed profound bilateral vision loss after the seventh cycle of nab-paclitaxel treatment. Optical coherence tomography and macula microperimetry demonstrated macular edema and decreased threshold sensitivity, respectively. Cessation of nab-paclitaxel improved structural and functional vision after 4 weeks. The introduction of topical dorzolamide 1% in one eye demonstrated further rapid resolution of edema...
March 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38530983/scleral-fixated-secondary-iols-an-outcomes-comparison-between-the-yamane-and-gore-tex-sutured-techniques
#12
JOURNAL ARTICLE
Sean C Drummond, Jack E Feist, Jason N Crosson, Asghar A Haider, Jonathan S Fuerst, Devon Askins Hughes, Richard M Feist
BACKGROUND AND OBJECTIVE: Among secondary intraocular lens (IOL) techniques, scleral fixated IOLs (SFIOLs) offer advantages in cases without capsular support. In this article, we compare outcomes between two types of Gore-Tex scleral sutured IOLs with the Yamane technique. PATIENTS AND METHODS: This study was a retrospective chart review of patients who underwent SFIOL implantation. RESULTS: Analysis revealed a statistically significant improvement in final postoperative visual acuity (VA) for sutured SFIOLs ( P < 0...
March 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38530567/enhancing-diabetic-macular-edema-treatment-outcomes-exploring-the-esaso-classification-and-structural-oct-biomarkers
#13
JOURNAL ARTICLE
Giacomo Panozzo, Maria V Cicinelli, Giulia Dalla Mura, Diana Giannarelli, Maria Vadalà, Vincenza Bonfiglio, Giovanni Bellisario, Francesco Bandello
INTRODUCTION: This study assessed the European School of Advanced Studies in Ophthalmology (ESASO) classification's prognostic value for diabetic macular edema (DME) in predicting intravitreal therapy outcomes. METHODS: In this retrospective, multicenter study, patients aged > 50 years with type 1 or 2 diabetes and DME received intravitreal antivascular endothelial growth factor (anti-VEGF) agents (ranibizumab, bevacizumab, and aflibercept) or steroids (dexamethasone)...
March 26, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38530451/the-longitudinal-follow-up-of-a-newly-proposed-octa-imaging-finding-sspim-and-the-importance-of-it-as-a-new-biomarker-for-treatment-response-in-diabetic-macular-edema
#14
JOURNAL ARTICLE
Gülsüm Genç, Özge Yanık, Sibel Demirel, Figen Batioglu, Emin Özmert
PURPOSE: This study aimed to evaluate the frequency of SSPiM (suspended scattering particles in motion), systemic risk factors, ocular findings, progression characteristics, and treatment response in diabetic retinopathy (DR) patients. METHODS: In this prospective study, a total of 109 eyes of 109 patients with diabetic macular edema (DME) were included. Demographic characteristics and systemic data of the patients were recorded. In addition to a detailed ophthalmological examination, optical coherence tomography (OCT) and OCT angiography (OCTA) imaging were performed...
March 26, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38529446/topical-dorzolamide-as-adjunctive-treatment-with-intravitreal-bevacizumab-in-bilateral-diabetic-macular-edema
#15
JOURNAL ARTICLE
Ata Sadr, Meisam Sargazi, Shahram Banaie, Mahdi Asani, Hassan Mehrad Majd, Seyed Omid Mohammadi, Alireza Maleki
BACKGROUND:  Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is accepted as the gold standard treatment for center-involving diabetic macular edema (CI-DME). Adjunctive administration of topical dorzolamide may enhance the therapeutic effects of anti-VEGF agents. In this study, we compared the efficacy of topical dorzolamide plus intravitreal injection of bevacizumab (IVB) versus IVB alone in patients with bilateral DME. METHODS: This prospective, randomized contralateral eye study was carried out in a tertiary referral ophthalmology center, Al-Zahra Eye Hospital, Zahedan, Iran, between April 2021 and April 2022...
February 2024: Curēus
https://read.qxmd.com/read/38529001/exacerbation-of-diabetic-retinopathy-following-hypoxia-inducible-factor-prolyl-hydroxylase-inhibitor-administration-a-case-report
#16
Nobuaki Ariyoshi, Fumiaki Higashijima, Makiko Wakuta, Tadahiko Ogata, Manami Ohta, Kazuhiro Kimura
INTRODUCTION: Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors, used in the treatment of renal anemia, hold the potential to increase the production of vascular endothelial growth factors. Therefore, HIF-PH inhibitors may exacerbate retinal hemorrhage in diseases such as diabetic retinopathy. Here, we present a case involving the administration of an HIF-PH inhibitor, resulting in the exacerbation of retinal hemorrhage in a patient with diabetic retinopathy. CASE PRESENTATION: A 32-year-old man with diabetes mellitus and renal anemia caused by diabetic nephropathy was referred to our department for ophthalmic examination, revealing diabetic retinopathy with scattered retinal hemorrhages, exudates, and diabetic maculopathy in both eyes...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38527570/38-gauge-cannula-based-endo-drainage-of-posteriorly-trapped-intraoperative-subretinal-fluid-during-vitrectomy-for-retinal-detachment
#17
JOURNAL ARTICLE
Aditya Bansal, Sumana C Naidu, Natalia Figueiredo, Mahmoud Alrabiah, Hesham Hamli, David T W Wong, Rajeev H Muni, Filiberto Altomare
The DRAIN STUDY evaluated a novel use of a 38-gauge Polytip® cannula for posteriorly trapped intraoperative subretinal fluid endo-drainage during pars plana vitrectomy in rhegmatogenous retinal detachment. Sixteen patients underwent this procedure, with an 81% single surgery success rate at 3 months postoperatively. Median visual acuity improved from 20/300 to 20/80. Two cases developed cystoid macular edema and epiretinal membrane. No postoperative residual subretinal fluid was observed. The 38-gauge cannula-based SRF drainage proved effective, offering an alternative to conventional methods for managing posteriorly trapped intraoperative subretinal fluid...
March 23, 2024: Ophthalmology Retina
https://read.qxmd.com/read/38527189/demographic-and-clinical-profile-of-pediatric-uveitis-in-delta-region-egypt
#18
JOURNAL ARTICLE
Nagwa Hussein Abdelmageed, Anas Adi, Samy Abo El-Khair, Maha Shahin, Doaa Mosad Mosa, Dalia Sabry, Amgad El Nokrashy
PURPOSE: Pediatric uveitis poses unique challenges, characterized by difficulties in performing comprehensive examinations, potential delays in diagnosis, and a heightened risk of ocular complications. This study evaluate the etiologic and clinical characteristics of uveitis in children presenting to the Mansoura Ophthalmic Center, Mansoura, Egypt. METHODS: A cross-sectional observational study was undertaken involving children diagnosed with uveitis attending the uveitis outpatient clinic at Mansoura University Ophthalmic Center...
March 25, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38526804/diabetic-disease-of-the-eye-in-canada-consensus-statements-from-a-retina-specialist-working-group
#19
JOURNAL ARTICLE
Amer Omar, R Geoff Williams, James Whelan, Jason Noble, Michael H Brent, Michel Giunta, Sébastien Olivier, Mustapha Lhor
Despite advances in systemic care, diabetic disease of the eye (DDE) remains the leading cause of blindness worldwide. There is a critical gap of up-to-date, evidence-based guidance for ophthalmologists in Canada that includes evidence from recent randomized controlled trials. Previous guidance has not always given special consideration to applying treatments and managing DDE in the context of the healthcare system. This consensus statement aims to assist practitioners in the field by providing a spectrum of acceptable opinions on DDE treatment and management from recognized experts in the field...
March 23, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38524349/progression-of-diabetic-retinopathy-following-uncomplicated-phacoemulsification-a-prospective-study-from-south-india
#20
JOURNAL ARTICLE
R Sruthi, Seshadri J Saikumar, Mahesh Gopalakrishnan
AIM: The aim of this study was to study the progression of diabetic retinopathy (DR) and macular edema in uncomplicated phacoemulsification in patients with diabetes mellitus with a follow-up of 6 months. METHODS: A prospective, nonrandomized study was conducted on patients with established or no DR in a known case of diabetes mellitus undergoing cataract surgery by phacoemulsification, with no intraoperative complications. Detailed ophthalmic evaluation including fundus examination was done in all cases, and DR staging was done...
2024: Oman Journal of Ophthalmology
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