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serous retinal detachment

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https://www.readbyqxmd.com/read/29689030/checkpoint-inhibitor-immune-therapy-systemic-indications-and-ophthalmic-side-effects
#1
Lauren A Dalvin, Carol L Shields, Marlana Orloff, Takami Sato, Jerry A Shields
PURPOSE: To review immune checkpoint inhibitor indications and ophthalmic side effects. METHODS: A literature review was performed using a PubMed search for publications between 1990 and 2017. RESULTS: Immune checkpoint inhibitors are designed to treat system malignancies by targeting one of three ligands, leading to T-cell activation for attack against malignant cells. These ligands (and targeted drug) include cytotoxic T-lymphocyte antigen-4 (CTLA-4, ipilimumab), programmed death protein 1 (PD-1, pembrolizumab, nivolumab), and programmed death ligand-1 (PD-L1, atezolizumab, avelumab, durvalumab)...
April 23, 2018: Retina
https://www.readbyqxmd.com/read/29681837/unusual-case-of-vogt-koyanagi-harada-disease-associated-with-sapho-syndrome-a-case-report
#2
Miyuki Hasegawa, Akira Fukutomi, Akiko Jinno, Kyoko Fujita, Motohiro Kamei
A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. The symptoms persisted in spite of treatment. She was then referred to our hospital. At her initial visit, the visual acuities were 0.6 in both eyes. A slit-lamp examination revealed bilateral shallow anterior chamber, and intraocular pressures of 18 mm Hg in the right eye and 16 mm Hg in the left eye...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29666121/clinical-features-and-visual-outcomes-of-111-patients-with-new-onset-acute-vogt-koyanagi-harada-disease-treated-with-pulse-intravenous-corticosteroids
#3
Makiko Nakayama, Hiroshi Keino, Takayo Watanabe, Annabelle A Okada
PURPOSE: To describe the clinical features, treatment and visual outcomes of Japanese patients with new-onset acute Vogt-Koyanagi-Harada (VKH) disease. METHODS: Clinical records of 111 patients who presented between 1999 and 2015 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo, were reviewed. RESULTS: Of the 111 patients (68 women, 43 men), 16 had complete, 90 had incomplete and 5 had probable VKH disease. The median follow-up period was 36 months (4-175 months)...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29643788/polypoidal-choroidal-vasculopathy-associated-with-optic-disc-coloboma
#4
Yumiko Nakano, Akiko Miki, Shigeru Honda, Makoto Nakamura
Purpose: To report a case of polypoidal choroidal vasculopathy associated with optic disc coloboma. Methods: Case report. Results: A 50-year-old woman presented with optic disc coloboma and retinochoroidal coloboma associated with subretinal hemorrhage and serous retinal detachment (SRD) in her left eye. Optical coherence tomography (OCT) confirmed SRD at the macula and showed a sharply elevated retinal epithelial detachment at the choroidal excavation...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29619858/influence-of-serous-retinal-detachment-on-the-outcome-of-ranibizumab-treatment-in-diabetic-macular-edema
#5
Nimet Yesim Ercalik, Serhat Imamoglu, Esra Turkseven Kumral, Nursal Melda Yenerel, Handan Bardak, Yavuz Bardak
PURPOSE: The purpose of this study was to evaluate the influence of serous retinal detachment (SRD) on the outcome of intravitreal ranibizumab (IVR) therapy in diabetic macular edema (DME). MATERIALS AND METHODS: Fifty-one eyes with cystoid macular edema (CME) and SRD (study group) and 57 eyes with only CME (control group) that received pro re nata (PRN) IVR injections during a 6-month period were retrospectively evaluated. The outcome measures included changes in the central macular thickness (CMT) and best corrected visual acuity (BCVA) and injection numbers...
April 5, 2018: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/29619248/retinal-and-choroidal-changes-in-steroid-associated-central-serous-chorioretinopathy
#6
Vikas Ambiya, Abhilash Goud, Mohammed Abdul Rasheed, Sankeert Gangakhedkar, Kiran Kumar Vupparaboina, Jay Chhablani
Background: To evaluate the retinal and choroidal alterations in steroid-associated central serous chorioretinopathy (CSC) in comparison to idiopathic CSC. Methods: In this retrospective cohort study, swept source optical coherence tomography scans of eyes with steroid-associated CSC (group A) were compared with the same in idiopathic CSC (group B). The key features included central subfield retinal thickness, subfoveal choroidal thickness, subfoveal large choroidal vessel diameter, subretinal deposits, retinal pigment epithelial irregularities, double layer sign, hyperreflective dots, intraretinal fluid, and choroidal vascularity index (ratio of choroidal luminal area and total choroidal area, measured on a high definition horizontal 9 mm OCT B-scan...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29595560/spironolactone-as-a-therapeutic-alternative-for-the-bullous-variant-of-central-serous-chorioretinopathy
#7
Eva C Ramos-Yau, Ediberto Muñoz-Domínguez, Silvia P Contreras-Mérida, Luis M Valencia-Londoño
PURPOSE: To report a case of the bullous variant of central serous chorioretinopathy successfully treated with spironolactone, a mineralocorticoid receptor antagonist. METHODS: Case report of a patient including fluorescein angiography, optical coherence tomography, and color fundus photography. RESULTS: Initially managed as a multifocal choroiditis, the use of oral and peribulbar corticoids worsened the serous retinal detachment. Taking in consideration this response, she was then diagnosed with a bullous variant of central serous chorioretinopathy and treated with 50 mg of spironolactone per day...
March 27, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29580759/uveitis-and-serous-retinal-detachment-secondary-to-systemic-dabrafenib-and-trametinib
#8
T Rueda-Rueda, J L Sánchez-Vicente, A Moruno-Rodríguez, F E Molina-Socola, A C Martínez-Borrego, F López-Herrero
CASE REPORT: The case is presented of a 39-year-old woman with metastatic melanoma treated with dabrafenib and trametinib. She presented with a severe acute panuveitis with granulomatous anterior uveitis, vitritis, and multiple serous retinal detachments. Dabrafenib and trametinib were suspended, and treatment with a systemic and topical corticosteroid was started. A good response was obtained, with a recovery of visual acuity of 1.0 in both eyes within two weeks. DISCUSSION: Dabrafenib and trametinib can lead to severe uveitis...
March 23, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29580756/case-series-of-ocular-involvement-due-to-dengue-first-reported-cases-in-guatemala
#9
M A Carrillo-Soto
OBJECTIVE: Describe the ocular findings of a case series of 8 patients with a diagnosis of dengue. MATERIALS AND METHODS: Review of clinical records and interviews with patients during outpatient visits, after informed consent was obtained and following the ethical standards of the Helsinki declaration. The patients were diagnosed with diagnosis by IgM / IgG dengue serology in whom ocular involvement was identified, between January and October 2017 in Retinal-vascular clinic of the "Dr...
March 23, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29575941/treatment-outcomes-of-conventional-or-high-dose-ranibizumab-for-vascularized-pigment-epithelial-detachment-based-on-lesion-subtypes
#10
Clement K Chan, David Sarraf, Prema Abraham
INTRODUCTION: A post hoc study was conducted to compare visual and anatomic outcomes of vascularized serous pigment epithelial detachment (Group 1) with fibrovascular pigment epithelial detachment (Group 2) due to age-related macular degeneration treated with either 0.5 or 2.0 mg ranibizumab injections. METHODS: A prospective, randomized trial was performed with the following regimens for 12 months: (1) 0.5 mg monthly, (2) 0.5 mg monthly for 4 months followed by pro re nata injections, (3) 2...
February 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29554817/dark-and-white-lesions-observed-in-central-serous-chorioretinopathy-on-optical-coherence-tomography-angiography
#11
Flore De Bats, Pierre-Loïc Cornut, Benjamin Wolff, Laurent Kodjikian, Martine Mauget-Faÿsse
PURPOSE: To describe abnormal dark (hyposignal) and white (hypersignal) lesions observed on optical coherence tomography angiography in central serous chorioretinopathy. METHODS: Prospective, multicenter, and descriptive study including patients with active or quiescent central serous chorioretinopathy. All patients had undergone a complete ophthalmic examination. RESULTS: Abnormal dark lesions were detected as "dark spots" and "dark areas" on optical coherence tomography angiography...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29554052/presentation-of-central-serous-chorioretinopathy-in-two-husband-and-wife-couples
#12
Aditya Kanesa-Thasan, Amani A Fawzi, Manjot K Gill
PURPOSE: Central serous chorioretinopathy (CSC) is a disease in which serous detachment of the neurosensory retina occurs over an area of leakage from the choriocapillaris through the retinal pigment epithelium. Associations have been drawn between high-stress personality types and steroid exposure. This article aims to describe a unique case series of two husband and wife couples with CSC. METHODS: All methods were approved by the authors' institution's institutional review board...
April 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29547451/retinal-microstructure-in-poems-syndrome
#13
Ryutaro Tomita, Tetsuju Sekiryu, Hiroaki Shintake, Kuniharu Saito
PURPOSE: To report a 67-year-old woman with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, showing bilateral serous retinal detachment. The retinal lesion was evaluated by multimodal imaging using spectral domain optical coherence tomography and an adaptive optics (AO) camera. METHODS: A case report. RESULTS: Optical coherence tomography showed hyperreflective foci mainly in the inner retina in both eyes...
March 15, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29517581/photodynamic-therapy-for-symptomatic-subfoveal-retinal-pigment-epithelial-detachment-in-central-serous-chorioretinopathy-outcomes-and-prognostic-factors
#14
Sungsoon Hwang, Se Woong Kang, Sang Jin Kim, Jun Won Jang, Kyung Tae Kim
PURPOSE: To report the clinical outcomes of reduced-fluence photodynamic therapy (PDT) for symptomatic subfoveal retinal pigment epithelial detachment (RPED) in central serous chorioretinopathy and identify prognostic factors affecting treatment outcome. METHODS: This retrospective interventional study included 35 eyes of 35 patients with serous subfoveal RPED with choroidal hyperpermeability. Cases with evidence of age-related macular degeneration were excluded from the study...
March 5, 2018: Retina
https://www.readbyqxmd.com/read/29503946/giant-retinal-pigment-epithelial-tear-associated-with-fluid-overload-due-to-end-stage-diabetic-kidney-disease
#15
Yusuke Kameda, Akira Hirose, Tomohiro Iida, Yasuko Uchigata, Shigehiko Kitano
Purpose: To report a case of a giant retinal pigment epithelial (RPE) tear associated with fluid overload in a patient with diabetic macular edema (DME) and kidney disease. Observations: A 60-year-old man with type 2 diabetes mellitus and end-stage diabetic kidney disease who had gained weight because of fluid overload complained of a visual disturbance in the left eye that had started a few days earlier. The left fundus showed a RPE defect in two temporal quadrants under an extensive serous retinal detachment (SRD) with exacerbation of the original DME...
April 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29502614/toxic-retinopathy-after-phacoemulsification-when-the-cefuroxime-dilution-is-correct
#16
Chengguo Zuo, Lan Mi, Dan Ye, Xinxing Guo, Hui Xiao, Mingxing Wu, Xing Liu
PURPOSE: To determine the clinical characteristics and outcomes of patients with toxic retinopathy after phacoemulsification and intraocular lens implantation when the correct cefuroxime dilution is administered. SETTING: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. DESIGN: Prospective case series. METHODS: Patients developing toxic retinopathy after phacoemulsification between January 2016 and April 2017 were observed...
January 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29489658/positron-emission-tomography-computed-tomography-scan-of-vogt-koyanagi-harada-syndrome-with-associated-autoimmune-thyroid-disease-a-case-report-and-literature-review
#17
Ke-Hao Huang, Ming-Cheng Tai, Lung-Chi Lee, Tzu-Heng Weng, Yi-Hao Chen, Li-Fan Lin, Jiann-Torng Chen, Da-Wen Lu, Ching-Long Chen
RATIONALE: Vogt-Koyanagi-Harada (VKH) syndrome is a rare disease and could be associated with autoimmune thyroid disease (AITD). This report was aimed to investigate the utility of F-fludeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) for the diagnosis of VKH syndrome with AITD and to perform a literature review on the association between the 2 diseases. PATIENT CONCERNS: A 55-year-old woman without the history of ocular trauma suffered from chronic headache...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29474223/inverted-internal-limiting-membrane-flap-technique-for-optic-disk-pit-maculopathy-morphologic-and-functional-analysis
#18
Giancarlo Sborgia, Nicola Recchimurzo, Luigi Sborgia, Alfredo Niro, Alessandra Sborgia, Marina Piepoli, Giovanni Alessio
PURPOSE: To analyze morphologic and functional changes after inverted internal limiting membrane-flap technique for optic disk pit maculopathy using optical coherence tomography, multifocal electroretinography, and microperimetry. METHODS: One case report. RESULTS: A 30-year-old woman presented us with decreased visual acuity (20/63) in the left eye because of retinoschisis and serous macular detachment associated with optic disk pit. Optical coherence tomography did not localize the source of intraretinal and subretinal fluid...
February 22, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29474221/profound-visual-recovery-at-16-months-after-resolution-of-serous-retinal-detachments-secondary-to-thrombotic-thrombocytopenic-purpura-case-report-and-literature-review
#19
Parker J Williams, William A Pearce, Jesse M Smith, Joshua Robinson
PURPOSE: To report a unique case of dramatic improvement in objective visual function during the recovery phase, after resolution of thrombotic thrombocytopenic purpura-related serous retinal detachments and to review prognostic trends in reported cases involving the macula. METHODS: Observational case report and literature review. RESULTS: A 36-year-old white woman with thrombotic thrombocytopenic purpura developed vision loss from serous retinal detachments in both eyes...
February 22, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29470299/choroidal-thickness-changes-in-a-patient-diagnosed-with-central-serous-chorioretinopathy-during-follow-up-for-pachychoroid-pigment-epitheliopathy
#20
Wataru Saito, Yuki Hashimoto, Kiriko Hirooka, Susumu Ishida
PURPOSE: To evaluate chronological changes in choroidal thickness in a patient with pachychoroid pigment epitheliopathy (PPE) who was later diagnosed with central serous chorioretinopathy (CSC) during follow-up. METHODS: Case report. RESULTS: A 43-year-old man complained of metamorphopsia in the left eye. Funduscopy showed several punctate white subretinal lesions at the macula, but no macular serous retinal detachment in the left eye. Retinal pigment epithelium abnormality without serous retinal detachment at the macula on optical coherence tomography and choroidal vascular hyperpermeability on indocyanine green angiography suggested PPE in the left eye...
February 21, 2018: Retinal Cases & Brief Reports
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