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https://www.readbyqxmd.com/read/29792838/systemic-solutions-in-retinopathy-of-prematurity
#1
Darius M Moshfeghi
PURPOSE: To describe a framework for screening and treatment of retinopathy of prematurity using telemedicine screening with laser and/or vascular endothelial growth factor inhibitor treatment strategies. DESIGN: Literature review and perspective METHODS: Review of the literature and the author's experience RESULTS: Undetermined CONCLUSIONS: Telemedicine can be deployed on a national basis to provide quaternary level screening for ROP. At-risk patients for treatment could then be directed to receive either laser photocoagulation or vascular endothelial growth factor inhibitor intravitreal injections followed at a later time point by examination under anesthesia, fluorescein angiography, and diode laser photocoagulation as indicated...
May 21, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29789899/-review-of-clinical-trials-in-retinopathy-of-prematurity-current-state-and-future-perspectives
#2
REVIEW
Andreas Stahl
BACKGROUND: The treatment of retinopathy of prematurity (ROP) has gained a new dynamic since the introduction of anti-vascular endothelial growth factor (VEGF) therapy. This review summarizes clinical trial data in order to aid informed decision-making. METHODS: In this article, pivotal clinical trials are summarized and discussed with regard to their implications for ROP therapy. RESULTS: The longest follow-up phase exists for children treated in the CRYO-ROP study, which used retinal cryocoagulation to treat ROP...
May 22, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29784227/evaluation-of-depression-and-anxiety-levels-in-mothers-of-babies-following-due-to-premature-retinopathy
#3
Nagihan Saday Duman, Emel Sarı Gökten, Rahmi Duman, Reşat Duman, Sadık Görkem Çevik
No abstract text is available yet for this article.
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29778284/-clinical-and-epidemiological-profile-of-pediatric-uveitis-course-of-inflammatory-uveitis-treated-with-anti-tnf-alpha
#4
D Osswald, A C Rameau, C Speeg-Schatz, J Terzic, A Sauer
INTRODUCTION: Uveitis is the leading cause of acquired childhood blindness with a prevalence of 30 cases per 100,000 inhabitants. There are multiple causes ; nevertheless, there is no standardized etiological assessment. The goal of our study is to define an epidemiological and clinical profile of uveitis diagnosed in a university hospital and their course when treated with anti-tumor necrosis factor (TNF) α. PATIENTS AND METHODS: All cases of uveitis under 18 years old, from 1994 to 2016, were included...
May 16, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29767696/clinical-outcomes-related-to-the-gastrointestinal-trophic-effects-of-erythropoietin-in-preterm-neonates-a-systematic-review-and-meta-analysis
#5
Anitha Ananthan, Haribalakrishna Balasubramanian, Shripada Rao, Sanjay Patole
Erythropoietin (EPO) plays an important role in the development and maturation of the gastrointestinal tract. Recombinant EPO (rEPO) has been used to prevent anemia of prematurity. The gastrointestinal trophic effects of EPO may reduce feeding intolerance and necrotizing enterocolitis (NEC) in preterm neonates. The aim of this systematic review of randomized controlled trials (RCTs) was to evaluate the effects of rEPO on clinical outcomes such as feeding intolerance, stage II or higher NEC, any stage NEC, sepsis, retinopathy of prematurity, and bronchopulmonary dysplasia in preterm neonates...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29753851/macular-structures-optical-components-and-visual-acuity-in-preschool-children-after-intravitreal-bevacizumab-or-laser-treatment
#6
Yung-Sung Lee, Lai-Chu See, Shu-Hao Chang, Nan-Kai Wang, Yih-Shiou Hwang, Chi-Chun Lai, Kuan-Jen Chen, Wei-Chi Wu
PURPOSE: To investigate the macular structures, optical components, and visual acuity in preschool-aged children with a history of type I retinopathy of prematurity who underwent either intravitreal bevacizumab (IVB), laser, or a combination of treatments. DESIGN: Comparative interventional case series. METHODS SETTING: A referred medical center in Taiwan. STUDY POPULATION: 80 eyes from 42 patients (33 IVB-treated eyes from 17 children, 24 laser-treated eyes from 13 children, and 23 laser + IVB-treated eyes from 12 children)...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29753546/sildenafil-and-retinopathy-of-prematurity-in-preterm-infants-with-bronchopulmonary-dysplasia
#7
David Aboudi, Nithya Swaminathan, Heather Brumberg, Qiuhu Shi, Deborah Friedman, Boriana Parvez, Usha Krishnan
OBJECTIVE: To assess whether sildenafil is associated with worsening retinopathy of prematurity (ROP) in very low birth weight (VLBW) infants (≤1500 g) with bronchopulmonary dysplasia (BPD). STUDY DESIGN: This retrospective case-control study included VLBW infants admitted to the neonatal intensive care unit between January 1, 2006, and December 31, 2012. Each infant treated with sildenafil was assigned 3 unexposed controls matched for gestational age, birth weight, and BPD diagnosis...
May 9, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29750954/neonatal-and-fetal-growth-charts-to-identify-preterm-infants-less-than-30-weeks-gestation-at-risk-of-adverse-outcomes
#8
Nansi S Boghossian, Marco Geraci, Erika M Edwards, Jeffrey D Horbar
BACKGROUND: It is unclear whether a neonatal or a fetal growth standard is a better predictor of adverse in-hospital newborn outcomes. OBJECTIVE: We aimed to evaluate and compare the power of birth weight for gestational age to predict adverse neonatal outcomes using neonatal and fetal growth charts. Gestational age specific birth weight was examined either as a centile score or as a binary indicator for birth weight below the 10th centile (small for gestational age) using three fetal growth charts (National Institute of Child Health and Human Development, World Health Organization, and Intergrowth-21st ) and one neonatal sex-specific birth weight chart...
May 8, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29742514/foveal-depression-and-related-factors-in-patients-with-a-history-of-retinopathy-of-prematurity
#9
Akiko Miki, Shigeru Honda, Yukako Inoue, Yuko Yamada, Makoto Nakamura
PURPOSE: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP). METHODS: We enrolled 112 patients (age: 6-15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. RESULTS: The ROP group demonstrated the worst VA and the shallowest foveal depression...
May 9, 2018: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29740191/neonatal-outcomes-of-extremely-preterm-infants-exposed-to-maternal-hypertension-and-cigarette-smoking
#10
Kamran Yusuf, Belal Alshaikh, Orlando da Silva, Abhay K Lodha, Robert D Wilson, Ruben E Alvaro, Shoo K Lee, Prakesh S Shah
OBJECTIVE: To study the outcomes of extremely preterm infants of hypertensive mothers who smoke. STUDY DESIGN: This retrospective cohort study included infants born between 2003 and 2012 at <29 weeks' gestation and admitted to neonatal intensive care units participating in the Canadian Neonatal Network. Infants were divided into four mutually exclusive groups. Infants of hypertensive mothers who smoked; infants of hypertensive, non-smoking mothers; infants of normotensive mothers who smoked; and infants of normotensive, non-smoking mothers...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29737539/increased-circulation-mobilization-of-endothelial-progenitor-cells-in-preterm-infants-with-retinopathy-of-prematurity
#11
Homa Babaei, Mahdi Alibabrdel, Simin Asadian, Vahid Siavashi, Masoome Jabarpour, Seyed Mahdi Nassiri
Retinopathy of prematurity (ROP) is a result of increased pathological neoangiogenesis of the retina in preterm infants. Cells responsible for the pathogenesis of ROP are unclear, but some evidence indicates that bone marrow derived cells are involved in this disorder. Endothelial progenitor cells (EPCs), play a role in angiogenesis in response to tissue ischemia or endothelial damage. In this study, the number of cEPCs in preterm infants with ROP was determined to identify whether the circulation mobilization of EPCs is associated with ROP...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29731355/the-erythropoietin-promoter-variant-rs1617640-is-not-associated-with-severe-retinopathy-of-prematurity-independent-of-treatment-with-erythropoietin
#12
Christof Dame, Lina K Sciesielski, Carolin Rau, Chiara-Aiyleen Badur, Christoph Bührer
In this case-control study, the erythropoietin (EPO) promoter variant s1617640, linked to high intravitreal EPO concentrations and increased risk of diabetic retinopathy, was not associated with severe retinopathy of prematurity. This finding was observed both in infants with and without recombinant EPO administration.
May 3, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29730824/gene-therapy-knockdown-of-vegfr2-in-retinal-endothelial-cells-to-treat-retinopathy
#13
Aaron B Simmons, Colin A Bretz, Haibo Wang, Eric Kunz, Kassem Hajj, Carson Kennedy, Zhihong Yang, Thipparat Suwanmanee, Tal Kafri, M Elizabeth Hartnett
Inhibition of vascular endothelial growth factor (VEGF) in retinopathy of prematurity (ROP) raises concerns for premature infants because VEGF is essential for retinovascular development as well as neuronal and glial health. This study tested the hypothesis that endothelial cell-specific knockdown of VEGF receptor 2 (VEGFR2), or downstream STAT3, would inhibit VEGF-induced retinopathy without delaying physiologic retinal vascular development. We developed an endothelial cell-specific lentiviral vector that delivered shRNAs to VEGFR2 or STAT3 and a green fluorescent protein reporter under control of the VE-cadherin promoter...
May 5, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29730594/adverse-effects-of-small-for-gestational-age-differ-by-gestational-week-among-very-preterm-infants
#14
Erik A Jensen, Elizabeth E Foglia, Kevin C Dysart, Rebecca A Simmons, Zubair H Aghai, Alison Cook, Jay S Greenspan, Sara B DeMauro
OBJECTIVE: To characterise the excess risk for death, grade 3-4 intraventricular haemorrhage (IVH), bronchopulmonary dysplasia (BPD) and stage 3-5 retinopathy of prematurity independently associated with birth small for gestational age (SGA) among very preterm infants, stratified by completed weeks of gestation. METHODS: Retrospective cohort study using the Optum Neonatal Database. Study infants were born <32 weeks gestation without severe congenital anomalies...
May 5, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29730341/blockade-of-trem-1-prevents-vitreoretinal-neovascularization-in-mice-with-oxygen-induced-retinopathy
#15
Modesto A Rojas, Zu T Shen, Ruth B Caldwell, Alexander B Sigalov
In pathological retinal neovascularization (RNV) disorders, the retina is infiltrated by activated leukocytes and macrophages. Triggering receptor expressed on myeloid cells 1 (TREM-1), an inflammation amplifier, activates monocytes and macrophages and plays an important role in cancer, autoimmune and other inflammation-associated disorders. Hypoxia-inducible TREM-1 is involved in cancer angiogenesis but its role in RNV remains unclear. Here, to close this gap, we evaluated the role of TREM-1 in RNV using a mouse model of oxygen-induced retinopathy (OIR)...
May 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29713524/refractive-and-biometric-outcomes-in-patients-with-retinopathy-of-prematurity-treated-with-intravitreal-injection-of-ranibizumab-as-compared-with-bevacizumab-a-clinical-study-of-correction-at-three-years-of-age
#16
Yen-Chih Chen, San-Ni Chen, Benjamin Chi-Lan Yang, Kun-Hsien Lee, Chih-Chun Chuang, Chieh-Yin Cheng
Purpose: To compare refractive and biometric outcomes in patients with type 1 retinopathy of prematurity (ROP) treated with intravitreal injection of ranibizumab (IVR) versus bevacizumab (IVB), at a corrected age of 3 years. Methods: A retrospective case series compared cycloplegic refractive statuses and biometric statuses in patients who received either IVR or IVB for type 1 ROP, from April 2011 to April 2014. Results: A total of 62 eyes (33 patients) with type 1 ROP were evaluated (26 eyes in 13 IVR patients and 36 eyes in 20 IVB patients)...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29710185/accuracy-and-reliability-of-eye-based-vs-quadrant-based-diagnosis-of-plus-disease-in-retinopathy-of-prematurity
#17
Sang Jin Kim, J Peter Campbell, Jayashree Kalpathy-Cramer, Susan Ostmo, Karyn E Jonas, Dongseok Choi, R V Paul Chan, Michael F Chiang
Importance: Presence of plus disease in retinopathy of prematurity is the most critical element in identifying treatment-requiring disease. However, there is significant variability in plus disease diagnosis. In particular, plus disease has been defined as 2 or more quadrants of vascular abnormality, and it is not clear whether it is more reliably and accurately diagnosed by eye-based assessment of overall retinal appearance or by quadrant-based assessment combining grades of 4 individual quadrants...
April 26, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29710127/plus-disease-in-retinopathy-of-prematurity-investigating-its-definition
#18
Samir N Patel
No abstract text is available yet for this article.
April 26, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29707411/case-report-of-proliferative-peripheral-retinopathy-in-two-familial-lissencephaly-infants-with-miller-dieker-syndrome
#19
Omar Shoukfeh, Alan B Richards, Leonard A Prouty, John Hinrichsen, William Rand Spencer, Marlyn P Langford
A complete ophthalmic examination is not routinely performed on infants with Miller-Dieker syndrome (MDS, chromosome 17p13.3 microdeletion). The authors present the cases of four cousins with MDS who also carried a 16p13.3 microduplication (not associated with Rubinstein-Taybi syndrome). Retinopathy of prematurity-like proliferative peripheral retinopathy (PPR) was detected in two male first cousins, but was not detected in the female half-cousins. PPR in the first infant resolved by 4 months, but the second infant's PPR progressed, requiring photocoagulation followed by lens-sparing vitrectomy...
June 2018: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/29701429/pharmacotherapy-and-rop-going-back-to-the-basics
#20
Julia P Shulman, M Elizabeth Hartnett
Retinopathy of prematurity (ROP) is a leading cause of blindness in preterm infants around the world. Through the development of animal models and clinical trials our understanding of the pathophysiology of this disease and approach to therapy has evolved significantly since ROP was first described in the 1940s in the United States. The mainstay of treatment in ROP remains ablative laser therapy to the avascular retina but pharmacologic agents are being more and more commonly used with new targets for pharmacotherapy emerging...
April 27, 2018: Asia-Pacific Journal of Ophthalmology
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