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https://www.readbyqxmd.com/read/29163363/human-prolactin-point-mutations-and-their-projected-effect-on-vasoinhibin-generation-and-vasoinhibin-related-diseases
#1
Jakob Triebel, Christin J Friedrich, Andreas Leuchs, Gonzalo Martínez de la Escalera, Carmen Clapp, Thomas Bertsch
Background: A dysregulation of the generation of vasoinhibin hormones by proteolytic cleavage of prolactin (PRL) has been brought into context with diabetic retinopathy, retinopathy of prematurity, preeclampsia, pregnancy-induced hypertension, and peripartum cardiomyopathy. Factors governing vasoinhibin generation are incompletely characterized, and the composition of vasoinhibin isoforms in human tissues or compartments, such as the circulation, is unknown. The aim of this study was to determine the possible contribution of PRL point mutations to the generation of vasoinhibins as well as to project their role in vasoinhibin-related diseases...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29152948/exogenous-erythropoietin-aggravates-retinal-neovascularizationin-a-murine-model-of-proliferative-retinopathy
#2
Ning Yang, Wenxi Zhang, Tao He, Yiqiao Xing
Background/aim: Erythropoietin (EPO) has been proven recently to be a critical mediator in retinal neovascularization (RNV). Previous studies have indicated that the use of recombinant human EPO (rEPO) is a high risk factor in the development of retinopathy of prematurity. In this study, we aimed to investigate the effect of rEPO administration on RNV and its underlying mechanism in a mouse model of oxygen-induced retinopathy (OIR). Materials and methods: A murine model of OIR was used to generate RNV. After daily intraperitoneal injection of rEPO from postnatal day 12 (P12), mice were euthanized at P17...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29145693/early-erythropoiesis-stimulating-agents-in-preterm-or-low-birth-weight-infants
#3
REVIEW
Arne Ohlsson, Sanjay M Aher
BACKGROUND: Preterm infants have low plasma levels of erythropoietin (EPO), providing a rationale for the use of erythropoiesis-stimulating agents (ESAs) to prevent or treat anaemia and to provide neuro protection and protection against necrotising enterocolitis (NEC). Darbepoetin (Darbe) and EPO are currently available ESAs. OBJECTIVES: To assess the effectiveness and safety of ESAs (erythropoietin (EPO) and/or Darbe) initiated early (before eight days after birth) compared with placebo or no intervention in reducing red blood cell (RBC) transfusions, adverse neurological outcomes, and feeding intolerance including necrotising enterocolitis (NEC) in preterm and/or low birth weight infants...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29137074/refractive-state-and-optical-compositions-of-preterm-children-with-and-without-retinopathy-of-prematurity-in-the-first-6-years-of-life
#4
Xiaohui Zhu, Rulian Zhao, Yang Wang, Lijuan Ouyang, Jing Yang, Yong Li, Lianhong Pi
This study aimed to investigate the refractive state and optical compositions of preterm children with and without mild retinopathy of prematurity (ROP) and explore the influence of prematurity and mild ROP on the development of refractive state and optical compositions.Preterm children who received fundus screening were recruited, and divided into ROP group and non-ROP group. Term children matched in age were also recruited as controls. Several correspondence indicators were measured before and after ciliary muscle paralysis with 1% cyclopentanone...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135357/short-term-refractive-effects-of-propranolol-hydrochloride-prophylaxis-on-retinopathy-of-prematurity-in-very-preterm-newborns
#5
Levent Korkmaz, Cagatay Karaca, Mustafa Ali Akin, Osman Bastug, Mustafa Sahiner, Ahmet Ozdemir, Tamer Gunes, Mehmet Adnan Ozturk, Selim Kurtoglu
PURPOSE: Retinopathy of prematurity (ROP) is one of the major problems of surviving premature infants with several ophthalmic morbidities such as increased risk of refractive errors, strabismus, and cortical visual impairment. Use of propranolol hydrochloride (PH) for the prevention of ROP is a new promising treatment modality. However, long-term effects are still to be defined. In our study, we aimed to investigate the short-term refractive effects of PH used for ROP prophylaxis in very preterm newborns...
November 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29131921/hot-topics-in-retinopathy-of-prematurity
#6
Irena Tsui, Alison Chu
Retinopathy of prematurity (ROP) is a condition seen in premature infants that is characterized by abnormal retinal blood vessel growth incited by relative hyperoxia and followed by hypoxia. It can have severe consequences ranging from high myopia to blindness. This article reviews recent "hot" topics related to ROP, specifically the changing incidence of ROP worldwide, the advent of predictive algorithms for screening for ROP, the emerging data behind efficacy of anti-vascular endothelial growth factor treatments for ROP, and advanced retinal imaging in children who were born premature...
November 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/29129724/retinal-vasculature-development-in-health-and-disease
#7
REVIEW
Senthil Selvam, Tejas Kumar, Marcus Fruttiger
Development of the retinal vasculature is based on highly coordinated signalling between different cell types of the retina, integrating internal metabolic requirements with external influences such as the supply of oxygen and nutrients. The developing mouse retinal vasculature is a useful model system to study these interactions because it is experimentally accessible for intra ocular injections and genetic manipulations, can be easily imaged and develops in a similar fashion to that of humans. Research using this model has provided insights about general principles of angiogenesis as well as pathologies that affect the developing retinal vasculature...
November 9, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29118491/retinopathy-of-prematurity-like-retinopathy-in-full-term-infants
#8
Dhanashree Ratra, Lala Akhundova, Manmath Kumar Das
PURPOSE: The purpose of this study is to assess clinical characteristics, risk factors, and management outcomes of retinal changes similar to retinopathy of prematurity (ROP), seen in full-term infants. PATIENTS AND METHODS: This is a retrospective review of 46 eyes of 23 patients, born at full term or near full term and diagnosed to have active ROP-like retinopathy or sequelae of ROP-like retinopathy. RESULTS: Mean birth weight (BW) and gestational age (GA) were 2342 ± 923 g (range, 1200-4160 g) and 38...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29113918/the-impact-of-diabetes-on-corneal-nerve-morphology-and-ocular-surface-integrity
#9
REVIEW
Maria Markoulli, Judith Flanagan, Shyam Sunder Tummanapalli, Jenny Wu, Mark Willcox
Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular complications, including nephropathy leading to kidney failure, potentially blinding diabetic retinopathy, and diabetic neuropathy. While the retinal complications of diabetes are well recognized by eye care professionals, the effects on the ocular surface are poorly understood...
November 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29113524/how-does-preeclampsia-affect-neonates-highlights-in-the-disease-s-immunity
#10
Lina R Marins, Leonardo B Anizelli, Ana L Sarquis, Mariana D Romanowski
INTRODUCTION: Preeclampsia (PE) is the primary obstetrical cause in one to four perinatal deaths. Although the etiology and pathogenesis of preeclampsia is not fully known, a proinflammatory immune state prevails and can disrupt fetal hematopoiesis. Some of the effects on the newborn include neonatal thrombocytopenia, neutropenia, a reduction in T regulatory cells and an increased cytotoxic natural killer cell profile. METHOD: Electronic databases were searched, and defined criteria were applied to select articles for review...
November 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29109051/ajo-centennial-evolving-concepts-in-the-management-of-retinopathy-of-prematurity
#11
Paul Sternberg, Alia K Durrani
PURPOSE: The introduction of anti-vascular endothelial growth factor (VEGF) agents has stimulated considerable reexamination of treatment strategies for the management of retinopathy of prematurity (ROP). Herein we will summarize and review evolving concepts and provide a personal perspective on clinical management today and future directions of treatment. DESIGN: Literature Review METHODS: To synthesize the evolving management concepts for diagnosis and treatment of retinopathy of prematurity and to provide interpretation and perspective on current emerging therapies...
November 3, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29103792/foveal-development-in-infants-treated-with-bevacizumab-or-laser-photocoagulation-for-retinopathy-of-prematurity
#12
Ryan N Vogel, Margaret Strampe, Oladipo E Fagbemi, Alexis Visotcky, Sergey Tarima, Joseph Carroll, Deborah M Costakos
PURPOSE: To characterize and quantify early foveal development in preterm infants and to compare this development between eyes treated with intravitreal bevacizumab or laser photocoagulation (LPC) and untreated eyes. DESIGN: Observational case series. PARTICIPANTS: One hundred thirty-one preterm infants undergoing retinopathy of prematurity (ROP) screenings. METHODS: Handheld OCT imaging was performed longitudinally on all patients...
November 2, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29098279/posterior-pole-vascular-changes-before-treatment-of-retinopathy-of-prematurity
#13
S Grace Prakalapakorn, David K Wallace, Sharon F Freedman
Importance: Some proponents of telemedicine screening for retinopathy of prematurity (ROP) believe that a screening system based on the characteristics of posterior pole vessels is sufficient for identifying infants needing treatment. Objective: To evaluate the vascular characteristics present when treatment was determined to be needed and the number of days from the last examination when the vessels of both eyes were noted to be normal until a decision was made to treat...
November 2, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29097614/two-year-neurodevelopmental-outcome-of-an-infant-born-at-21-weeks-4-days-gestation
#14
Kaashif A Ahmad, Charlotte S Frey, Mario A Fierro, Alexander B Kenton, Frank X Placencia
Recent literature confirms that, at the lower limit of extrauterine survival, substantial intercenter variability exists in resuscitation practice. The reasons for this variability are unclear, but may be related to disagreement on how to apply the best interests standard to extremely premature infants. Currently, both obstetric and pediatric societies recommend against assessing for viability or attempting resuscitation before 22 weeks' gestation. In this context, we report the unimpaired 2-year outcome of a female infant resuscitated after delivery at 21 weeks' 4 days' gestation and 410 g birth weight...
November 2, 2017: Pediatrics
https://www.readbyqxmd.com/read/29097178/delayed-versus-early-umbilical-cord-clamping-for-preterm-infants-a-systematic-review-and-meta-analysis
#15
Michael Fogarty, David A Osborn, Lisa Askie, Anna Lene Seidler, Kylie Hunter, Kei Lui, John Simes, William Tarnow-Mordi
OBJECTIVE: To compare the effects of delayed versus early cord clamping on hospital mortality (primary outcome) and morbidity in preterm infants using Cochrane Collaboration Neonatal Review Group methodology. DATA SOURCES: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Chinese articles, cross-referencing citations, expert informants and trial registries to 31 July 2017. STUDY ELIGIBILITY: RCTs of delayed (≥ 30 seconds) vs early (<30 seconds) clamping in infants born <37 weeks gestation...
October 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29095432/pregnancy-induced-hypertension-and-neonatal-outcomes-a-systematic-review-and-meta-analysis
#16
A Razak, A Florendo-Chin, L Banfield, M G Abdul Wahab, S McDonald, P S Shah, A Mukerji
OBJECTIVE: Pregnancy-induced hypertension (PIH) is associated with preterm delivery but its independent impact on neonatal outcomes remains unclear. We sought to systematically review and meta-analyze clinical outcomes of preterm infants <37 weeks' gestation born to mothers with and without PIH. STUDY DESIGN: Medline, Embase, PsychINFO and CINAHL were searched from January 2000 to October 2016. Studies with low-moderate risk of bias reporting neonatal outcomes based on PIH as primary exposure variable were included...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29095074/evaluation-of-retinopathy-of-prematurity-incidence-with-telemedicine-confirmation-in-gansu-china-a-pilot-study
#17
Xinxin Zhang, Yuping Wang, J Niklas Ulrich, Yi Yang, Leona Ding, Yi Yang, Ding Xu, Kristina Tarczy-Hornoch, Michelle T Cabrera
PURPOSE: To determine the incidence of retinopathy of prematurity (ROP) in Gansu, China by combining bedside examinations with remote RetCam (Clarity Medical Systems, Pleasanton, CA, USA) diagnosis. METHODS: ROP screening via indirect ophthalmoscopy followed by RetCam imaging was performed from 2014 to 2015. Three ROP-experienced ophthalmologists interpreted images remotely. Incidence of ROP was determined by combining bedside and telemedicine diagnoses. RESULTS: Of 139 examined infants and 137 complete records, 20 (14...
November 2, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29092682/evaluation-of-dynamic-thiol-disulfide-homeostasis-in-very-low-birth-weighted-preterms
#18
Sezin Unal, Dilek Ulubas Isik, Ahmet Yagmur Bas, Sara Erol, İlter Arifoglu, Murat Alisik, Ozcan Erel, Nihal Demirel
BACKGROUND: Thiols are organic compounds containing sulfhydryl groups which exert antioxidant effects via dynamic thiol-disulfide homeostasis. The shift towards disulfides indicates the presence of oxidative environment. Thiol-disulfide homeostasis has not been evaluated in neonates. We aimed to evaluate dynamic thiol-disulfide homeostasis in preterm infants. METHODS: Preterm infants with birth weight less than 1500 grams (25-32 weeks of gestation) were included...
November 1, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29092057/health-system-dynamics-analysis-of-eyecare-services-in-trinidad-and-tobago-and-progress-towards-vision-2020-goals
#19
Tasanee Braithwaite, Blaine Winford, Henry Bailey, Petra Bridgemohan, Debra Bartholomew, Deo Singh, Subash Sharma, Rishi Sharma, Juan Carlos Silva, Alastair Gray, Samuel S Ramsewak, Rupert R A Bourne
Avoidable blindness is an important global public health concern. This study aimed to assess Trinidad and Tobago's progress towards achieving the Pan American Health Organization, 'Strategic Framework for Vision 2020: The Right to Sight-Caribbean Region,' indicators through comprehensive review of the eyecare system, in order to facilitate health system priority setting. We administered structured surveys to six stakeholder groups, including eyecare providers, patients and older adult participants in the National Eye Survey of Trinidad and Tobago...
October 30, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29091306/effects-of-apelin-on-retinal-microglial-cells-in-a-rat-model-of-oxygen-induced-retinopathy-of-prematurity
#20
Wei Zhang, Ding-Guo Zhang, Xing Liang, Wei-Liang Zhang, Jing-Xue Ma
This study explores the effects of apelin on retinal microglial cells in rat models of oxygen-induced retinopathy of prematurity (ROP). Totally, 274 rats were selected for establishing oxygen-induced retinopathy (OIR) models, and 92 healthy rats for control group. OIR rats were assigned into OIR, 10(-5) g/L apelin, 10(-4) g/L apelin and 10(-3) g/L apelin groups. Immunohistochemistry was employed to determine morphology of microglial cells and cell number. CDllb, ionized calcium-binding adapter molecule 1 (IBA-1), TNF-α and iNOS mRNA and protein expressions were identified using RT-qPCR and western blotting, respectively...
November 1, 2017: Journal of Cellular Biochemistry
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