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beta-lactam allergy

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https://www.readbyqxmd.com/read/27888034/a-proactive-approach-to-penicillin-allergy-testing-in-hospitalized-patients
#1
Justin R Chen, Scott A Tarver, Kristin S Alvarez, Trang Tran, David A Khan
BACKGROUND: Penicillin allergy testing is underutilized in inpatients despite its potential to immediately impact antibiotic treatment. Although most tested patients are able to tolerate penicillin, limited availability and awareness of this tool leads to the use of costly and harmful substitutes. OBJECTIVE: We established an inpatient service at a large academic hospital to identify and test patients with a history of penicillin allergy with the goals of removing inaccurate diagnoses, reducing the use of beta-lactam alternatives, and educating patients and clinicians about the procedure...
November 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27888028/identifying-allergic-drug-reactions-through-placebo-controlled-graded-challenges
#2
Melissa Iammatteo, Denisa Ferastraoaru, Rebecca Koransky, Santiago Alvarez-Arango, Niharika Thota, Ayobami Akenroye, Elina Jerschow
BACKGROUND: Graded challenges are performed to exclude hypersensitivity reactions in patients with a low likelihood of drug allergy. Literature regarding optimal protocols with a defined number of steps and use of placebo is lacking. OBJECTIVE: To identify allergic drug reactions (ADRs) through a 3-step protocol composed of placebo followed by a 2-step graded drug challenge. METHODS: We performed a 5-year retrospective chart review of all patients with historical ADRs who underwent single-blind, placebo-controlled graded drug challenges between October 2010 and November 2015 at an outpatient drug allergy clinic...
November 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27852424/hypersensitivity-to-beta-lactam-antibiotics-a-three-year-study
#3
I Mota, Â Gaspar, M Chambel, S Piedade, M Morais-Almeida
BACKGROUND: Beta-lactams antibiotics (BL) are the most frequent elicitors of allergic drug reactions. The aim of our study was to characterize the patients referred with suspected hypersensitivity (HS) to BL. METHODS: Over a three-year period (2011-2013), a total of 234 adult and paediatric patients (pts) with suspected HS to BL were investigated according to the European Network for Drug Allergy guidelines. RESULTS: HS to BL was confirmed in 43 pts (18%), without differences between adult and paediatric pts; anaphylaxis was reported by 20 pts...
November 2016: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27745795/impact-of-a-pharmacist-driven-beta-lactam-allergy-interview-on-inpatient-antimicrobial-therapy-a-pilot-project
#4
Nicholas S Sigona, Jeffrey M Steele, Christopher D Miller
OBJECTIVES: To determine the impact of a pharmacist-driven beta-lactam allergy interview on antimicrobial therapy. SETTING: Tertiary care academic medical center. PRACTICE SETTING: Clarification of beta-lactam allergy may expand treatment options for patients and potentially improve outcomes, reduce toxicity, and reduce costs. PRACTICE INNOVATION: At our institution, a pilot service using a pharmacy resident and infectious diseases clinical pharmacist was implemented to clarify beta-lactam allergy information and, where appropriate, recommend a change to the patient's antibiotic therapy...
October 8, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27569064/optimal-step-doses-for-drug-provocation-tests-to-prove-beta-lactam-hypersensitivity
#5
Anca-Mirela Chiriac, Ticha Rerkpattanapipat, Philippe-Jean Bousquet, Nicolas Molinari, Pascal Demoly
BACKGROUND: Drug provocation tests (DPT) are commonly performed as part of ß-lactam allergy work-up, in case of negative skin tests, and in the absence of contraindications. The recommendations of learned societies have created a frame for DPT performance, but protocols vary widely between centres, generating various hypothesis-driven protocols (i.e., empirical dosing, driven by both safety concerns and practical aspects). METHODS: The primary objective of this retrospective analysis was to detect eliciting dose thresholds (reactive doses) during ß-lactam DPT, using the survival analysis method, in order to suggest optimal step doses...
August 29, 2016: Allergy
https://www.readbyqxmd.com/read/27560911/-evaluation-and-characterization-of-125-patients-with-a-history-of-reaction-to-beta-lactams
#6
Kaddy Juliana Beltrán-Sierra, Jorge Sánchez, Ricardo Cardona
BACKGROUND: Reactions to beta-lactams are frequent and it is difficult to establish the relationship between the drug and symptoms. OBJECTIVE: To describe the clinical characteristics and explore the immunological mechanisms of patients with suspected adverse reaction to beta-lactams. METHODS: Retrospective study of patients with a history of beta-lactam reaction and tests for reactions to drugs. RESULTS: Out of 125 patients, 71 were women (56...
July 2016: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/27543745/performance-in-real-life-of-the-european-network-on-drug-allergy-algorithm-in-immediate-reactions-to-beta-lactam-antibiotics
#7
E Moreno, E Laffond, F Muñoz-Bellido, M T Gracia, E Macías, A Moreno, I Dávila
European Network on Drug Allergy (ENDA) has proposed an algorithm for diagnosing immediate beta-lactam (BL) allergy. We evaluated its performance in real life. During 1994-2014, 1779 patients with suspected immediate reactions to BL were evaluated following ENDA's short diagnostic algorithm. Five hundred and nine patients (28.6%) were diagnosed of BL hypersensitivity. Of them, 457 (25.7%) were at first evaluation [403 by skin tests (ST), 12 by positive IgE and 42 by controlled provocation tests (CPT)]. At second evaluation (SE), 52 additional patients (10...
December 2016: Allergy
https://www.readbyqxmd.com/read/27530619/the-revolving-door-antibiotic-allergy-labelling-in-a-tertiary-care-centre
#8
Brittany Knezevic, Dustin Sprigg, Jason Seet, Michelle Trevenen, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew McLean-Tooke, Michaela Lucas
BACKGROUND: Patients frequently report antibiotic allergies, however only 10% of labelled patients have a true allergy. AIM: We investigated the documentation of antibiotic "allergy" labels (AALs) and the effect of labelling on clinical outcomes, in a West Australian adult tertiary hospital. METHODS: Retrospective cross-sectional analysis of patients captured in the 2013 and 2014 National Antimicrobial Prescribing Surveys. Data was collected on documented antibiotic adverse drug reactions, antibiotic cost, prescribing appropriateness, prevalence of multi-drug resistant organisms, length of stay, intensive care admission, and readmissions...
August 17, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27459839/-basopil-activation-test-bat-as-a-novel-method-for-monitoring-occupational-exposure-to-beta-lactams-and-intermediates-of-production
#9
COMPARATIVE STUDY
Paolo Marraccini, Patrizia Pignatti, Cosimo Cafforio, Marco Emilio Prini
BACKGROUND: Cutaneous tests and specific IgE are used in the diagnosis of allergy due to beta-lactans, although drug administration at therapeutic dosage is considered gold standard in drug allergy. OBJECTIVES: The diagnostic approach in symptomatic workers is more critical when they are exposed because of work, unlike reactions to drug in case of therapy. There is not a general consensus about markers in workers occupationally exposed to drugs. Indeed, basophil activation test (BAT) is a new and promising laboratory tool, particularly useful to test intermediate molecules involved in the production...
April 2016: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/27427544/-spanish-society-of-pediatric-infectious-diseases-spanish-society-of-paediatric-clinical-immunology-and-allergy-spanish-association-of-paediatric-primary-care-and-the-spanish-society-of-extra-hospital-paediatrics-and-primary-health-care-consensus-document-on
#10
Fernando Baquero-Artigao, Antonio Michavila, Ángeles Suárez-Rodriguez, Anselmo Hernandez, Leticia Martínez-Campos, Cristina Calvo
The suspected allergy to beta-lactam antibiotics, especially penicillin and amoxicillin, is the most frequent reason for consultation in Child Allergy Units. In this consensus document, the clinical and diagnostic criteria of allergic reactions are described, as well as alternative antibiotic treatment for the most common infections diagnosed in paediatrics for patients with known or suspected allergy.
July 15, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27421128/-community-acquired-pneumonia-treatment-options-according-to-the-international-recommendations
#11
Katarzyna Lewandowska, Jan Kuś
Pneumonia remains one of the main reasons of heath care system utilization. Quick diagnosis and prompt treatment initiation determine favorable outcome. Empirical antibiotic treatment allows to achieve treatment success in most patients. Treatment recommendations are based on big epidemiological trials. Nevertheless, it is sometimes necessary to know the definite etiologic factor of pneumonia. In these cases microbiological diagnostics is useful, i.e. sputum microscopy and culture, blood culture, bronchial lavage culture, bacterial antigen tests in urine, molecular tests...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27402820/impact-of-reported-beta-lactam-allergy-on-inpatient-outcomes-a-multicenter-prospective-cohort-study
#12
Derek R MacFadden, Anthony LaDelfa, Jessica Leen, Wayne L Gold, Nick Daneman, Elizabeth Weber, Ibrahim Al-Busaidi, Dan Petrescu, Ilana Saltzman, Megan Devlin, Nisha Andany, Jerome A Leis
BACKGROUND: Reported allergy to beta-lactam antibiotics is common and often leads to unnecessary avoidance in patients who could tolerate these antibiotics. We prospectively evaluated the impact of these reported allergies on clinical outcomes. METHODS: We conducted a trainee-led prospective cohort study to determine the burden and clinical impact of reported beta-lactam allergy on patients seen by infectious diseases consultation services at 3 academic hospitals...
October 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27369813/empiric-systemic-antibiotics-for-hospitalized-patients-with-severe-odontogenic-infections
#13
Matthias Zirk, Johannes Buller, Peter Goeddertz, Daniel Rothamel, Timo Dreiseidler, Joachim E Zöller, Matthias Kreppel
INTRODUCTION: Odontogenic infections may lead to severe head and neck infections with potentially great health risk. Age, location of purulent affected sites and beta-lactam allergy are some mentionable factors regarding patients' in-hospital stay and course of disease. Are there new challenges regarding bacteria' antibiotic resistance for empiric treatment and what influences do they have on patients' clinical course? METHODS: We analyzed in a 4-year retrospective study the medical records of 294 in-hospital patients with severe odontogenic infections...
August 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27302696/cross-sectional-questionnaire-based-internet-study-self-perception-and-clinical-course-of-drug-allergy-in-greece
#14
Michael P Makris, Theodoros N Sergentanis, Xenophon Aggelides, Stamatios Tzanninis, Efthimia Polyzou, Dimitrios Rigopoulos, Theodora Psaltopoulou
BACKGROUND: Data on self perception of drug allergy in the general population are lacking. Epidemiological studies focus either on specific populations or document adverse drug reactions in general. Our objective was to document self-reported drug allergy in Greece, through a simple, informative internet-based questionnaire. METHODS: A questionnaire on drug allergy was accessible online for a 3-month period. Participants voluntarily answered 28 questions referring to: suspected drug, clinical manifestations, concomitant factors, received treatment, reaction's re-occurrence...
June 11, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27180242/effectiveness-of-sequential-intravenous-to-oral-antibiotic-switch-therapy-in-hospitalized-patients-with-gram-positive-infection-the-sequence-cohort-study
#15
D Rodriguez-Pardo, C Pigrau, D Campany, V Diaz-Brito, L Morata, I C de Diego, L Sorlí, S Iftimie, R Pérez-Vidal, G García-Pardo, T Larrainzar-Coghen, B Almirante
Switching from intravenous to oral antibiotic therapy may improve inpatient management and reduce hospital stays and the complications of intravenous treatment. We aimed to assess the effectiveness of intravenous-to-oral antibiotic switch therapy and an early discharge algorithm in hospitalized patients with gram-positive infection. We performed a prospective cohort study with a retrospective comparison cohort, recruited from eight tertiary, acute-care Spanish referral hospitals. All patients included had culture-confirmed methicillin-resistant gram-positive infection, or methicillin-susceptible gram-positive infection and beta-lactam allergy and had received intravenous treatment with glycopeptides, lipopeptides, or linezolid...
August 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27012019/potentially-inappropriate-prescription-in-patients-with-a-history-of-allergy-to-%C3%AE-lactam-antibiotics-a-health-care-challenge
#16
A Manzaneque, C López-Cabezas, M Mensa, A García-Moral, J Sánchez-López, J Bartra, A Luis Valero
No abstract text is available yet for this article.
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/26999792/non-immediate-hypersensitivity-reactions-to-beta-lactam-antibiotics-in-children-our-10-year-experience-in-allergy-work-up
#17
Marina Atanaskovic-Markovic, Francesco Gaeta, Biljana Medjo, Marija Gavrovic-Jankulovic, Tanja Cirkovic Velickovic, Vladimir Tmusic, Antonino Romano
BACKGROUND: Non-immediate reactions to beta-lactam antibiotics (BL) occur more than one hour after drug administration, and the most common manifestations are maculopapular exanthemas and delayed-appearing urticaria and/or angioedema. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions (DHR), if a drug is taken at the same time. The most of children are labeled as 'drug allergic' after considering only the clinical history. OBJECTIVE: To diagnose/detect a hypersensitivity or an infection which mimic DHR in children with non-immediate reactions to BL METHODS: A prospective survey was conducted in a group of 1026 children with histories of non-immediate reactions to BL by performing patch tests, skin tests, and in case of negative results, drug provocation tests (DPTs)...
August 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/26981866/documenting-penicillin-allergy-the-impact-of-inconsistency
#18
Nirav S Shah, Jessica P Ridgway, Natasha Pettit, John Fahrenbach, Ari Robicsek
BACKGROUND: Allergy documentation is frequently inconsistent and incomplete. The impact of this variability on subsequent treatment is not well described. OBJECTIVE: To determine how allergy documentation affects subsequent antibiotic choice. DESIGN: Retrospective, cohort study. PARTICIPANTS: 232,616 adult patients seen by 199 primary care providers (PCPs) between January 1, 2009 and January 1, 2014 at an academic medical system...
2016: PloS One
https://www.readbyqxmd.com/read/26920651/lack-of-uniformity-in-the-investigation-and-management-of-suspected-%C3%AE-lactam-allergy-in-children
#19
Ru-Xin Melanie Foong, Kirsty Logan, Michael Richard Perkin, George du Toit
BACKGROUND: Beta-lactam allergy is commonly suspected in childhood with health implications for the individual and wider public. Diagnostic modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) tests, intradermal tests (IDT) and drug provocation challenges (DPC). The aim of this research was to establish whether variation exists around the world in the investigation and management of beta-lactam allergy. METHODS: Anonymized electronic questionnaire surveys were distributed over 3 months through International Allergy Societies for completion by clinicians who investigate drug allergy in children...
August 2016: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/26898316/cross-reactivity-among-beta-lactams
#20
REVIEW
Antonino Romano, Francesco Gaeta, Maria Francisca Arribas Poves, Rocco Luigi Valluzzi
Penicillins and cephalosporins are the major classes of beta-lactam (BL) antibiotics in use today and one of the most frequent causes of hypersensitivity reactions to drugs. Monobactams, carbapenems, oxacephems, and beta-lactamase inhibitors constitute the four minor classes of BLs. This review takes into account mainly the prospective studies which evaluated cross-reactivity among BLs in subjects with a well-demonstrated hypersensitivity to a certain class of BLs by performing allergy tests with alternative BLs and, in case of negative results, administering them...
March 2016: Current Allergy and Asthma Reports
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