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lung cancer staging or diagnostic

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https://www.readbyqxmd.com/read/29333007/utility-of-cluster-of-differentiation-5-and-cluster-of-differentiation-117-immunoprofile-in-distinguishing-thymic-carcinoma-from-pulmonary-squamous-cell-carcinoma-a-study-on-1800-nonsmall-cell-lung-cancer-cases
#1
Vidya Jha, Preeti Sharma, Ashish Kumar Mandal
Background: Mediastinum harbors a mixed bag of neoplastic lesions with varied therapeutic and prognostic implications. Distinguishing pulmonary squamous cell carcinoma from thymic carcinoma is a challenging task owing to rather nonspecific clinicoradiological features and a considerable overlap in histomorphological features. Thus, we evaluated the diagnostic utility of cluster of differentiation 5 (CD5) and CD117 immunohistochemical markers in distinguishing these tumors. Materials and Methods: The archives of department of histopathology were retrospectively reviewed from June 2012 to May 2016...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29333006/rational-use-of-imaging-to-stage-breast-cancer-evidences-for-a-selective-approach
#2
S G D Gangadaran
Introduction: Staging investigations at diagnosis are customary to accurately assign a clinical stage before therapy. The practice of routine imaging in patients asymptomatic for metastasis is not recommended but widely adopted. This study was done to reexamine the basis behind guideline recommendations and to identify the factors predictive of asymptomatic metastasis. Methods: Oncology records of 200 breast cancer patients in clinical Stages I-III at diagnosis were prospectively reviewed...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332448/helical-therapy-is-safe-for-lung-stereotactic-body-radiation-therapy-despite-limitations-in-achieving-sharp-dose-gradients
#3
Neha P Amin, Adrian Nalichowski, Shauna Campbell, Jal Hyder, Robyn Spink, Andre A Konski, Michael Dominello
PURPOSE: We observed that many of our helical therapy lung stereotactic body radiation therapy plans did not meet the Radiation Therapy Oncology Group (RTOG) recommended R50% (volume of 50% of the prescription dose/planning target volume), which characterizes the steepness of dose fall off. We hypothesized that despite not meeting R50%, helical therapy lung stereotactic body radiation therapy plans would confer similar local control and minimal side effects as previously reported using nonhelical treatment platforms...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29332331/egfr-mutations-and-tumor-metastases-in-patients-with-nonsmall-cell-lung-cancer-in-the-south-of-russia
#4
Oleg I Kit, Dmitry I Vodolazhsky, Natalia N Timoshkina, Lubov' Yu Vladimirova, Igor N Turkin, Ksenia A Kutsyn, Yaroslav S Enin, Svetlana B Panina, Vladimir Jurisic
PURPOSE: To assess the frequencies of somatic EGFR mutations in the tumor tissues of patients with non-small cell lung cancer (NSCLC) residing in the South of Russia (SR), and to define the relationship between genetic subtypes of NSCLC and the emergence of different types of metastases. METHODS: DNA was extracted from formalin-fixed parrafin embedded (FFPE) samples of 721 patients. A total of 29 somatic EGFR mutations were detected using commercial Therascreen EGFR RGQ PCR Kit...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332329/modified-3-week-schedule-of-gemcitabine-plus-cisplatin-for-non-small-cell-lung-cancer-treatment
#5
Antonello Veccia, Viviana Murgia, Mariachiara Dipasquale, Orazio Caffo
PURPOSE: Gemcitabine-cisplatin combination is one of the most used schedules for non small cell lung cancer (NSCLC). Aiming to enhance dose intensity and reduce toxicity, the original 4-week schedule was modified or transformed into a 3-week schedule. The purpose of this study was to report the efficacy and tolerability of a modified 3-week regimen of gemcitabine-cisplatin. METHODS: Our patients were treated with gemcitabine (1000 mg7sol;m2) on days 1, 8 and cisplatin on day 8 (75-100 mg/m2)...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332328/carcinoembryonic-antigen-and-carbohydrate-antigen-19-9-serum-levels-in-non-small-cell-lung-cancer
#6
Nikolaos Tsoukalas, Ioannis D Kostakis, Constantinos Giaginis, Maria Tolia, Michail Galanopoulos, Maria Kiakou, Eleni Aravantinou-Fatorou, Konstantinos Tsapakidis, Panagiotis Baxevanos, Ioannis Litos, Vasiliki Tzouda, Alexandros Tzovaras, George Kyrgias, Evangelos Tsiambas, Stamatios Theocharis
PURPOSE: Τo investigate the potential diagnostic and prognostic role of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) serum levels in non-small cell lung cancer (NSCLC). METHODS: One hundred consecutive patients with newly diagnosed primary NSCLC were included in this study (88 men and 12 women). Blood was drawn before any kind of treatment and the collected serum was processed using chemiluminescence in order CEA and CA 19-9 levels to be measured...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29329989/reassessment-of-right-middle-lobe-lung-cancer-comparison-of-segments-4-and-5-tumors
#7
Yoshinori Handa, Yasuhiro Tsutani, Takuhiro Ikeda, Hideaki Hanaki, Yoshihiro Miyata, Hidenori Mukaida, Morihito Okada
BACKGROUND: The purpose of this study is to elucidate the clinical behavior of right middle lobe lung cancer, with focus on the tumor location. METHODS: We reviewed retrospectively 711 patients who underwent lobectomy or bilobectomy for clinical stage I non-small cell lung cancer (upper lobe, 346; middle lobe, 82; lower lobe, 283). Factors affecting survival were assessed by log-rank tests and Cox regression analyses. RESULTS: The prognosis of patients with segment 5 tumors (n = 39) was significantly worse than that of patients with segment 4 tumors (n = 43; 5-year overall survival [OS] rates, 69...
January 9, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29329067/case-report-iatrogenic-brachial-artery-dissection-with-complete-anterograde-occlusion-during-elective-arterial-line-placement
#8
Laurence Weinberg, Diana Abu-Ssaydeh, Manfred Spanger, Patrick Lu, Michael H-G Li
INTRODUCTION: Brachial arterial catheters provide a more accurate reflection of central aortic arterial pressure compared to their radial counterparts. Although brachial arterial line complications are uncommon, we report a case of a rare iatrogenic brachial artery dissection with complete anterograde occlusion from elective arterial line placement. PRESENTATION OF CASE: A 41-year-old female presented for a right upper and middle lobe resection of a large neuroendocrine lung cancer...
December 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29327789/imaging-macrophage-distribution-and-density-in-mammary-tumors-and-lung-metastases-using-fluorine-19-mri-cell-tracking
#9
Ashley V Makela, Paula J Foster
PURPOSE: The presence of tumor-associated macrophages (TAMs) correlates with breast cancer progression and metastatic spread. Metastasis-associated macrophages (MAMs) are also recruited to distant sites, where they support metastatic growth. In this study, we demonstrate that in vivo fluorine-19 (19 F)-based MRI cell tracking can evaluate the density and distribution of macrophages within murine breast cancer tumors and associated metastases. METHODS: Three murine breast cancer cell lines with different metastatic potentials (4T1, 168FARN, and 67NR) were implanted into the mammary fat pad in mice...
January 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29327422/prognosis-and-distribution-of-lymph-nodes-metastases-in-resectable-primary-pulmonary-lymphoepithelioma-like-carcinoma-a-large-cohort-from-a-single-center
#10
Xiangyang Yu, Yingsheng Wen, Rongqing Qin, Yongbin Lin, Xuewen Zhang, Weidong Wang, Yongqiang Chen, Lanjun Zhang
BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma is a rare subtype of lung cancer. Until now, the characteristics of lymph nodes metastases in resectable cases have not yet been reported. METHODS: In this study, a total of 87 consecutive patients with primary pulmonary lymphoepithelioma-like carcinoma that received surgical treatment were investigated from October 1999 to August 2016. The clinical and radiological data and follow-up information were extracted from hospital records in detail...
January 12, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29327288/expression-of-pfkfb3-and-ki67-in-lung-adenocarcinomas-and-targeting-pfkfb3-as-a-therapeutic-strategy
#11
Xiaoli Li, Jian Liu, Li Qian, Honggang Ke, Chan Yao, Wei Tian, Yifei Liu, Jianguo Zhang
Phosphofructokinase-2/fructose-2, 6-bisphosphatase 3 (PFKFB3) catalyzes the synthesis of F2,6BP, which is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1): the rate-limiting enzyme of glycolysis. During tumorigenesis, PFKFB3 increases glycolysis, angiogenesis, and tumor progression. In this study, our aim was to investigate the significance of PFKFB3 and Ki67 in human lung adenocarcinomas and to target PFKFB3 as a therapeutic strategy. In this study, we determined the expression levels of PFKFB3 mRNA and proteins in cancerous and normal lung adenocarcinomas by quantitative reverse transcription PCR (qRT-PCR), Western blot analysis, and tissue microarray immunohistochemistry analysis, respectively...
January 11, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29327241/a-suvmax-based-propensity-matched-analysis-of-stereotactic-body-radiotherapy-versus-surgery-in-stage-i-non-small-cell-lung-cancer-unveiling-the-role-of-18f-fdg-pet-ct-in-clinical-decision-making
#12
L Ye, F Xu, S Shi, Z Zeng, X Jin, Y Huang, C Lu, J Gu, D Ge, J He
BACKGROUND: The value of maximum standard uptake value (SUVmax) was overlooked in current studies comparing stereotactic body radiotherapy (SBRT) versus surgery for stage I non-small cell lung cancer (NSCLC). Herein, we aimed to compare the 3-year outcomes based on patients for whom SUVmax were available, and to explore the role of SUVmax in clinical decision-making. METHODS: From January 2010 to June 2016, data of eligible patients were collected. Patient variables and clinical outcomes were compared in both unmatched and matched groups using propensity score matching (PSM)...
January 11, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29327178/clinical-impact-and-risk-factors-for-skeletal-muscle-loss-after-complete-resection-of-early-non-small-cell-lung-cancer
#13
Shinkichi Takamori, Gouji Toyokawa, Tatsuro Okamoto, Mototsugu Shimokawa, Fumihiko Kinoshita, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Takaki Akamine, Kazuki Takada, Masakazu Katsura, Fumihiko Hirai, Fumihiro Shoji, Tetsuzo Tagawa, Yoshinao Oda, Hiroshi Honda, Yoshihiko Maehara
BACKGROUND: A relationship between sarcopenia diagnosed by skeletal muscle area (SMA) and poor prognosis in cancer patients has recently been reported. This study aimed to clarify the clinical significance of postoperatively decreased SMA in patients with early non-small cell lung cancer (NSCLC). METHODS: This study selected 101 patients with pathologic stage 1 NSCLC who had undergone pre- and postoperative (~ 1 year) computed tomography scans and lobectomy between 2005 and 2010 at Kyushu University Hospital...
January 11, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29326090/the-addition-of-chemotherapy-to-radiation-therapy-improves-survival-in-elderly-patients-with-stage-iii-non-small-cell-lung-cancer
#14
Eric D Miller, James L Fisher, Karl E Haglund, John C Grecula, Meng Xu-Welliver, Erin M Bertino, Kai He, Peter G Shields, David P Carbone, Terence M Williams, Gregory A Otterson, Jose G Bazan
INTRODUCTION: Elderly patients represent the majority of lung cancer diagnoses but are poorly represented in clinical trials. We evaluated the overall survival (OS) of elderly patients with stage III non-small cell lung cancer (NSCLC) treated with definitive radiation compared to those treated with definitive chemoradiation. METHODS: We conducted a comparative effectiveness study of radiation therapy vs. chemoradiation in elderly (≥70 years old) patients with stage III NSCLC not treated surgically diagnosed from 2003-2014 using the National Cancer Database...
December 18, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29325801/editorial-the-role-of-medical-physics-in-lung-sbrt
#15
EDITORIAL
Pietro Mancosu, Andrew Nisbet, Núria Jornet
Stereotactic body radiation therapy (SBRT) has become a standard treatment for non-operable patients with early stage non-small cell lung cancer (NSCLC). In this context, medical physics community has largely helped in the starting and the growth of this technique. In fact, SBRT requires the convergence of many different features for delivering large doses in few fractions to small moving target in an heterogeneous medium. The special issue of last month, was focused on the different physics challenges in lung SBRT...
January 9, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29325035/amplicon-based-next-generation-sequencing-of-plasma-cell-free-dna-for-detection-of-driver-and-resistance-mutations-in-advanced-non-small-cell-lung-cancer
#16
N Guibert, Y Hu, N Feeney, Y Kuang, V Plagnol, G Jones, K Howarth, J F Beeler, C P Paweletz, G R Oxnard
Background: Genomic analysis of plasma cell-free DNA is transforming lung cancer care, however available assays are limited by cost, turnaround time, and imperfect accuracy. Here we study amplicon-based plasma next-generation sequencing (NGS), rather than hybrid-capture-based plasma NGS, hypothesizing this would allow sensitive detection and monitoring of driver and resistance mutations in advanced non-small cell lung cancer (NSCLC). Methods: Plasma samples from patients with NSCLC and a known targetable genotype (EGFR, ALK/ROS1 and other rare genotypes) were collected while on therapy and analyzed, blinded to tumor genotype...
January 9, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29323170/droplet-digital-pcr-based-egfr-mutation-detection-with-an-internal-quality-control-index-to-determine-the-quality-of-dna
#17
Sung-Su Kim, Hyun-Jeung Choi, Jin Ju Kim, M Sun Kim, In-Seon Lee, Bohyun Byun, Lina Jia, Myung Ryurl Oh, Youngho Moon, Sarah Park, Joon-Seok Choi, Seoung Wan Chae, Byung-Ho Nam, Jin-Soo Kim, Jihun Kim, Byung Soh Min, Jae Seok Lee, Jae-Kyung Won, Soo Youn Cho, Yoon-La Choi, Young Kee Shin
In clinical translational research and molecular in vitro diagnostics, a major challenge in the detection of genetic mutations is overcoming artefactual results caused by the low-quality of formalin-fixed paraffin-embedded tissue (FFPET)-derived DNA (FFPET-DNA). Here, we propose the use of an 'internal quality control (iQC) index' as a criterion for judging the minimum quality of DNA for PCR-based analyses. In a pre-clinical study comparing the results from droplet digital PCR-based EGFR mutation test (ddEGFR test) and qPCR-based EGFR mutation test (cobas EGFR test), iQC index ≥ 0...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323162/high-co-expression-of-il-34-and-m-csf-correlates-with-tumor-progression-and-poor-survival-in-lung-cancers
#18
Muhammad Baghdadi, Hiraku Endo, Atsushi Takano, Kozo Ishikawa, Yosuke Kameda, Haruka Wada, Yohei Miyagi, Tomoyuki Yokose, Hiroyuki Ito, Haruhiko Nakayama, Yataro Daigo, Nao Suzuki, Ken-Ichiro Seino
Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates the identification of novel factors that associates with disease progression and malignant degree for improving diagnostic and therapeutic strategies. Recent progress in cancer immunology research has unveiled critical roles for colony stimulating factor 1 receptor (CSF1R) in multiple aspects of the tumor microenvironment. CSF1R is expressed on tumor-associated macrophages (TAMs), and mediates important pro-tumorigenic functions...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322797/effectiveness-of-nanoparticle-albumin-bound-paclitaxel-plus-carboplatin-in-non-small-lung-cancer-patients-with-malignant-pleural-effusion
#19
N Koyama, Y Watanabe, Y Iwai, C Miwa, Y Nagai, K Aoshiba, H Nakamura
Malignant pleural effusion (MPE) is a common complication occurring in cancer patients, and its management affects the prognosis of these patients. Preclinical and clinical studies have reported that treatment with nanoparticle albumin-bound paclitaxel (nab-paclitaxel) plus carboplatin (CBDCA) is effective against intraperitoneal malignant tumors. To investigate the effectiveness of nab-paclitaxel plus CBDCA therapy for MPEs arising in patients with non-small cell lung cancer (NSCLC), we retrospectively analyzed the clinicopathological characteristics of 40 patients with stage IIIb or IV NSCLC who were treated with nab-paclitaxel plus CBDCA from 2013 to 2016...
2018: Neoplasma
https://www.readbyqxmd.com/read/29322682/stereotactic-ablative-radiotherapy-versus-lobectomy-for-stage-i-non-small-cell-lung-cancer-a-systematic-review
#20
Siwei Wang, Xiaoxiao Wang, Qing Zhou, Youtao Xu, Wenjia Xia, Weizhang Xu, ZhiFei Ma, Mantang Qiu, Ran You, Lin Xu, Rong Yin
BACKGROUND: There is debate regarding the use of stereotactic ablative radiotherapy (SABR) or surgery for patients with early stage non-small cell lung cancer (NSCLC). This meta-analysis compared the clinical efficacy of SABR and lobectomy in stage I NSCLC patients. METHODS: An online search identified eight eligible articles (including 2 trials and 7 cohort studies) for inclusion. The odds ratio (OR) was used as a summary statistic. Overall survival (OS), cause-specific survival (CSS), and recurrence-free survival (RFS) were selected to calculate ORs with 95% confidence intervals (CI)...
January 11, 2018: Thoracic Cancer
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